Dr.Istvan Berczi:
Department of Immunology ,
Faculty of Medicine,
University of Manitoba
Bannatyne Campus
471 Apotex Center ,
750 McDermot Avenue,
Winnipeg, Manitoba ,
R3E 0T5, Canada
Attendance
at a course on "Modern Methods of Separation of Biological Chemical
Compounds"
given under the auspices of the Hungarian
Chemical Society.
1969:
Participated
in an "Advanced Course on Immunologic Methodology" given by an International
faculty at Laval University, Quebec City, Quebec, Canada, under the auspices
of the Canadian Society
for Immunology.
Attended
the N.A.T.O.
Advanced Study Institute on "Cellular Differentiation and Regulation
of the Immune Response" organized at Minaki Lodge, Ontario, Canada
During
this period, studied neonatal enteric disease of calves and piglets due
to enterotoxic strains of E.Coli,with special emphases on the possible
role of endotoxin in these conditions.
1967
- 1968:
Researcher Institute
of Experimental Medicine and Surgery,
University
of Montreal, Quebec, Canada
research
focus:
During
these investigations, I familiarized myself with a number of specialized
surgical procedures on experimental animals.Familiarized myself also
with the pathology and histology of models of human diseases such as endocrine
disorders, cardiopathies, soft tissue calcification, etc.
Jan.-Sept.1969:
Researcher Laboratory
for Biophysical and Immunochemistry
McGill
University
Montreal,
Quebec, Canada
research
focus:
To
became familiar with basic procedures
in
the field of cellular and humoral immunity. Initiated research in Tumor
Immunology.
Full
time appointment in Department of Immunology, During this time I established
a laboratory which is preoccupied with hormonal immunoregulation and some
problems of tumor immunology research. Another important function of my
laboratory is the training of students registered in the Department of
Immunology and of postdoctoral fellows.
Six
month sabbatical research.. During this time period conducted research
in the field of human B lymphocyte regulation, incollaboration with Professor
George Klein.
During
this period worked on The Neuroimmune Biology book series, especially on
volume 3. A project was initiated here jointly with Dr. Phelps and colleagues.
The aim was the studying of the influences of the hypothalamus in allergic
reaction.
Distribution
of Academic Duties (2005/2006):
Teaching
2%
Research/Scholarly
Activities
62%
Administrative/
Service
1%
External
Service
35%
At
present: Full time research
Teaching:
1963
- 1967:
Demonstrator
of undergraduates in courses of:
Microbiology
and Immunology
University
of Veterinary Sciences,Veterinary School
Budapest
, Hungary
1972-
to date:
Staff
Member:
Department
of Immunology,
Faculty
of Medicine
University
of Manitoba
Winnipeg,
Manitoba, Canada
Courses
taught:
Med
1 Immunology: This
interdisciplinary course deals with the molecular and cellular mechanisms
underlying immunologically mediated diseases.
Immunobiology
(72.702): This
course provides a broad perspective of the evolving concepts of the mechanisms
underlying the regulation of the immune response.
Immunology
Methodology (72.704): This
lecture course is designed to provide an understanding of modern methods
used for basic research in Immunology or other biomedical disciplines utilizing
immunological techniques.
Selected
Topics in Immunology (72.706) This
course was conducted with the participation of mature students. Controversial
problems in Immunology were assigned to students. They were requested to
read relevant papers, evaluate and present the subject matter to their
classmates. Debate and discussion followed by the entire group with the
teacher’s participation. The group concluded the debate collectively.
Introductory
Immunology (72.707): This
course provides a broad survey of modern immunology, covering such topics
as molecular concepts of antigenic specificity, chemistry of antibodies
and their interactions with antigens and cells, regulation of the immune
response, transplantation and Tumor Immunology.
Molecular
Immunology (72.711): This
course covers in depth the structure, molecular biology and function of
immunoglobulins, histocompatibility antigens, regulatory factors, receptors
and adhesion molecules on cells of the immune system, mechanisms of immunochemical
reactins and the immunogenicity of antigens.
These
courses are given by several faculty members of the Department of Immunology
and occasionaly by faculty members of other departments.
My
lectures are comprised mostly of the topics of immunoglobulin diversity,
Fc-receptors, natural killer cell receptors, cell mediated and tumor immunology,
Immunopathology, and Neuro - Endocrine - Immune interactions.
At present I do not teach as a
Senior Scholar.
Publications: 198
papers, book chapters; 73 abstracts
Research
Interests: Past and Present
Investigation
on the hormonal regulation of the immune system. (current research)
The
role of pituitary hormones, especially of prolactin, in immunoregulation
(current research)
The
role of the intermediate lobe of the pituitary gland in immunoregulation,
with special emphasis on vasopressin (current research)
Developement
of flavonid steroid hormone analogues (current research)
The
therapeutic application of Gladular kallikrein (K1) which is a business venture with the
University of Manitoba, and has been patented and licensed for commercial development. I serve as an
Advisor to this project. (ongoing).
Salivary
immunoregulation and immunological tolerance.(ongoing)
Studies
on tumor immunobiology.(PhD work. Supervisor. Prof. Alec
Sehon)
Immunomodulation
by antiestrogens.
Studies
on immunity to persistent viral infections.
Research
directed to the development of monoclonal antibodies to various
antigens.
The
immunobiology of bacterial endotoxins.(Research done at the Veterinary MEdical
Research Institute of the Hungarian Academi of Sciences. Director, Prof. J.
Meszaros)
Studies
on Soft Tissue Calcification (Research at the Institute of experimental Medicine and Surey, University of Montreal.
Director: Prof. Hans Selye).
Most Significant
Scientific Contributions
1
Discovered the
production of antibodies to parasitic organisms in fish [Z Immun Forsch
1965;129:263-267].
2
Performed
comparative studies with bacterial endotoxin (LPS), which revealed that
mammals are very susceptible, whereas lover animals show significant
resistance to intoxication [Can. J. Microbiol 1966:12:1070-71].
3
Orally
administered endotoxin was harmless whereas parenterally given endotoxin
elicited shock and death in rats [Zbl Vet Med Reihe B 1966:13:570-575. J Path
Bact 1968;96:487-491].
4
Endotoxin
may be neutralized by antibodies [Z Immun Forsch 1967;132:303-307].
5
Salicylates
inhibit various calcifying connective tissue reactions [Arch Int Pharmacodyn
1969;177:211-223].
6
Fatty
acids influence soft tissue calcification [Exp Med Surg 1970;18:245-255].
7
Discovered
the cytotoxic potential of tumor-infiltrating lymphocytes (TIL) [Science
1973;180:1289-1291].
8
Discovered
that antibodies are capable of delivering cytotoxic drugs to target cells and
induce immunologically specific killing [J Nat Cancer Inst 1974;52:1665-1667].
9
Discovered
that the pituitary gland is an immunoregulatory organ [Acta Endocrinol 1978;89:530-537].
10
Dicovered
that prolactin is an immunoregulatory hormone [Allergy 1981;36:429-431;
Arthritis Rheum 1982;25:591-594].
11
Growth
and lactogenic hormones are immunoregulatory [Acta Endocrinol 1983;102:351-357; Allergy 1983;38:325-330].
12
The
dopamine-agonist drug, bromocriptine, is an immunosuppressive agent [Immunopharmacology
1983;6:231-243].
13
The
anti-estrogenic drug, tamoxifen, is immmunoregulatory [Immunopharmacology
1986;12:145-153].
14
Bone
marrow function is pituitary dependent [Brit J Haematol 1989;71:457-462].
15
Growth
and lactogenic hormones regulate c-myc and DNA synthesis in lymphoid tissue [J
Immunol 1991;146:2201-2206].
16
Prolactin
is able to maintain vital bodily functions for long periods. Hypophysectomized
rats depend on residual prolactin for survival. Endocrinology
1991;128:2776-2784
17
Prolactin
shows deficient bioactivity in patients with rheumatoid arthritis [J Rheumatol
1991;18:1662-1668].
18
Placental
lactogen is a hemopoietic hormone [Brit J Haematol 1991;79:355-358].
19
The
hypothalamus-pituitary-adrenal (HPA) axis controls the magnitude of tumor
necrosis factor (TNF) response to bacterial endotoxin (LPS) in mice. The HPA
axis defends the host against endotoxin shock [Brain Behav Immun
1992;6:157-169].
20
Target
cells are sensitized for cytotoxic T lymphocyte, natural killer (NK) and
lymphokine activated killer (LAK) cell mediated destruction by estradiol and
tamoxifen [Int J Cancer 1994;58:64-68].
21
Acute febrile illness (Acute
phase response) is an important host defense reaction that involves the
massive activation of the natural immune system and the suppression of
adaptive immunity [Ann. N.Y. Acad. Sci. 840: 787-802,1998; Ann NY Acad
Sci 2001;917:248-257].
22
Anti
estrogens potentiate the immunotherapy of syngeneic tumors in mice [Anticancer
Res 1997;17: 1083-1088; Anticancer Res 1997;17:77-84; Anticancer Res
1997;17:3647-3652; Anticancer Res 1997;17:3653-3658].
23
Glandular kallikrein from the
salivary submandibular gland of rats is an immunoregulatory enzyme [Neuroimmunomodulation
1997;4:107-112].
24
Antiestrogens
sensitize human ovarian and lung carcinomas for lysis by autologous killer
cells. [Anticancer Res 2000;20:2027-31].
25
Antiestrogens affect both the grandzyme-mediated
and the apoptotic pathways of killer cell-mediated oncolysis [Anticancer Res
2000;20:1849-53].
26
Glandular kallikrein
is required for the induction of oral immunological tolerance against
collagen-induced arthritis in rats [In “Neuroimmune Biology Volume 1: New
foundation of Biology” Berczi I, Gorczynski R, Editors, Elsevier, 2001;pp.
225-235].
27
Neurointermediate
Pituitary Lobectomy suppresses Humoral and Cell-mediated Immune Responses in
Rats. Neuroimmunomodulation 2004;11:233-240.
28
Neurointermediate
pituitary lobectomy decreases the incidence and severity of experimental
autoimmune encephalomyelitis in Lewis rats. J. Endocrinol.184, 51-58, 2005
29
Hypophysectomy
and Neurointermediate Pituitary Lobectomy Reduce Serum IgM, IgG and Intestinal
IgA Responses to Salmonella typhimurium
Infection in Rats. Infection and Immunity. 2006;74:1883-1889
30
Vasopressin
regulates immune functin and recovery from disease Ann N Y Acad Sci.
2009;1153:220-39
31
Flavonoid
derivatives function as ligands for steroiod receptorsJ. Med. Chem. 2008;51:3562-3571
PATENTS
On
the basis of the above listed discoveries, antibodies against endotoxins 4),
tumor infiltrating lymphocytes (7), drug-antibody conjugates (8),
bromocryptine (12) gained clinical applications. It was discovered that anti
estrogens amplify tumor immunity, which led to more extensive use of these
agents (13,20, 22,24, 25, patented).
Currently the commercial use of glandular Kallikrein is under way with the participation of The University of Manitoba,
who has licensed the patent rights to Sunomune Incorporated
(26, US and Canadian patents are underway).
International Patent:
A method for the sensitization of cancer cells for killer cell mediated lysis.
Description:
Adjuvant treatment with anti-estrogens (e.g. tamoxifen, toremifen) is proposed
for the immunotherapy of cancer.
Joint inventors: E.
Baral, E.Nagy, I Berczi, L. Kangas
US
and Canadian Patents:The
therapeutic uses of glandular kallikrein.
Description: Glandular
kallikrein is immunosuppressive and it is required for the induction of oral
immunological tolerance. It is proposed that kallikrein may be used as an
adjuvant for the treatment of autoimmune diseases by orally administered
antigen.
Joint inventors: I.Berczi, E. Sabbadini, E. Nagy; "Therapeutic Uses
of
Glandular Kallikrein".
USA: US/2003/02163601 USSN 10/163697
Canada CA2349748A1.
Books
donated to the Medical Library in Winnipeg.
1
Berczi
I, Szentivanyi A, Series editors, Berczi I, Gorczynski R, Editors: Neuroimmune
Biology Volume 1; New Foundation of Biology. Elsevier, Amsterdam, 2001.
2
Berczi
I, Szentivanyi A, Series Editors, Matera L, Rapaport R, Editors, Neuroimmune
Biology Volume 2: Growth and Lactogenic Hormones. Elsevier, Amsterdam, 2002.
3
Berczi
I. Szentivanyi A. Series Editors and Editors, Neuroimmmune Biology, Volume 3:
The Immune-Neuroendocrine Circuitry. History and Progress. Elsevier,
Amsterdam, 2003.
4
Berczi
I, Szentivanyi A, Series editors, Straub RH, Mocchegiani E. Editors: Neuroimmune Biology
Volume 4; The
Neuroendocrine Immune Network in Ageing. Elsevier,
Amsterdam, 2004.
5
Berczi,
I. Szentivanyi A, Series editors, Bertok L, Chow DA. Eds. Neuroimmune Biology
volume 5. Natural Immunity. Elsevier, Amsterdam, 2005.
6
Berczi,I.
Szentivanyi A, Series editors, Phelp, C, Korneva, E. Eds. Neuroimmune Biology
coluiume 6. Cytokines and the Brain. Elsevier Amsterdam. 2008.
7
Berczi,I.
Szentivanyi A, Series editors, del Rey A. Chrousos G. Besedovsky H.
Eds.Neuroimmune Biology, volume 7 The hypothalamus pituitary adrenal axis.
Elsevier, Amsterdam, 2008.
8
Berczi,I.
Szentivanyi A, Series editors, Jancso, G. Ed. Neuroimmune Biology, volume 8
Neurogenic Inflammation in Helath and Disease. Elsevier, Amsterdam, 2008.
9
Berczi,I.
Szentivanyi A, Series editors, Arnason BG. Neuroimmune Biology volume 9. The
brain and host defence. Elsevier, Amsterdam, 2010.
Research
Grants/Financial Aid: The
research programs conducted since 1972 have been supported by grants from:
Book
award for Neuroimmune Biology, volume 2. Growth and lactogenic hormones. Ed.
Istvan Berczi, Andor Szentivanyi, Elsevier, 2004. Second
prize (“highly commanded”) by the British Medical Association.
Extracurricular
Activities:
Invited
presentations:
1
Invited
Speaker:
Conference
on:" Psychoneuroimmunology",
May
27 - 28, 1985;
The
Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Title:
"Immunoregulatory aspects of the pituitary function."
2
Third
Gordon Research Conference on Prolactin
Feb.
3- 7, 1986
Oxnard,
California
Discussion
Leader: On "A New Prolactin Target - The Immune System."
3
Annual
meeting of:" The Canadian Andrology and Fertility Society",
Oct.
14 - 17, 1987
Val
David, Quebec, Canada
Title:
"Prolactin and its inter- relationship with the immune system."
4
FASEB
Summer Conference:" Neuroimmunomodulation",
June
26 - July 1, 1988
Copper
Mountain, Colorado, USA
Title:
"Immunoregulation by the pituitary gland."
5
Invited
plenary lecture:
Fourth"
International Society of Developmental and Comparative
Immunology
"Congress
July
24 - 29, 1988
Nottingham,England
Title:
" Immunoregulation by neuroendocrine factors."
6
Invited
lecture:
Kamilio
Eisner Symposia on:" Aging of Biological Communication System", Sept.
28 - Oct. 2, 1988
Innsbruck,
Austria
Title:
" Protein hormones in the Immune response."
7
Boehringer
Ingelheim Fonds International Titisee Conference on:
"Immune-Endocrine
Interaction",
March
6 - 12, 1991
Germany
Title:
" Effects of Growth Hormone and Prolactin on Immune Function."
8
Seminar
on Substance Abuse and the Brain-Immune Axis, an international symposia,
June
17 - 18, 1993
Toronto,
Ontario, Canada
Title:
"Direct effects of Prolactin on immune cells."
9
The
4th Naito Conference on:" Neuro-Immuno-Endocrine Networks",
Nov.
25 -28, 1994
Gifu,
Japan
Title:
" Prolactin, growth hormone and immunocompetence."
10
2nd
World Congress of Cellular and Molecular Biology,
Sept.1
- 7, 1996
Ottawa,
Ontario, Canada
Title:"The
regulation of killer cell induced apoptosis by steroid hormones."
11
Invited
plenary lecture:
International
Society for Neuroimmunomodulation, Third International Congress
Nov.
13 - 15, 1996
NIH,
Bethesda, MD, USA
Title:
"Neurohormonal host defence in endotoxin shock."
12
Invited
lecture:
23
International Symposium "Growth Hormone and Growth Factors in Endocrinology
and Metabolism"
April
11 - 12, 1997
Paris,
France
Title:"Pituitary
hormones and immune function."
13
Invited
lecture:
International
Symposia on:"Stress and Endotoxins"
June
30, 1997
Babolna,
Hungary
Title:"The
Neuroendocrine response to Endotoxins."
14
Plenary
lecture:
International
Symposium on: "Stress of Life. Stress and Adaptation from Molecules to
Man"
July
1 - 5, 1997
Budapest,
Hungary
Title:
" The stress concept and neuroimmunoregulation in modern biology"
Title:
" Endotoxin, superantigens and host defence. "
15
International
Workshop on: "Immune-Endocrine Interactions"
Bundesforschungsanstalt
für Landswirtschaft.
Nov.
21-22, 1997
Institute
für tierzucht und tierverhalten
Mariensee,
Germany
Title:
"Neuroimmunoregulation and Natural Immunity."
16
Plenary
lecture:
Fourth
Internation Congress of Immunology and Allergy
May
13 - 15, 1998
Isfahan,
Iran
Title:
" Neuroimmunregulation in Health and Disease."
17
Invited
speaker:
"A
Tribute to Hans Selye" Symposium organized at: the 1998 Annual meeting
of the Hungarian Medical Association of America
Oct.
26, 1998
Sarasota,
FL. USA
Title:
"Stress and the Immune System."
18
Plenary
lecture:
Fourth
International Congress of the International Society for Neuroimmunomodulation.
Sept.
29 - Oct. 2, 1999
Lugano,
Switzerland
Title:
Natural
Immunity and Neuroimmune Host Defence.
19
Plenary
lecture:
International
Symposium on Growth Hormone in Immune Reconstitution.
Oct.
7 - 10, 1999
St.
Petersburgh Beach, Florida, USA
Title:
Growth
Hormone, prolactine and immune function.
20
Plenary
lecture:
Canadian
Symposium on Neuroimmune Biology
June
9 - 12, 2000
Faculty
of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Title:
Neuroimmune
Biology - An Introduction.
21
Plenary
lecture:
First
International Conference on Metals and the Brain.
Sept
20 - 23, 2000
Padova,
Italy
Title:Toxic
insults and the neuroimmune regulatory network.
22
Plenary
lecture:
VII:
International Conference on Allergy and Immunology and Global Networks:
Insights into the next milleneum.
April
14 - 17, 2001
New
York, New York, USA
Title:
Neuroimmune
Biology. Current status and future perspectives.
23
Plenary
lecture:
VIII:
International Conference on Allergy, Immunology and Global Networks.
April
21 - 24, 2002
Cannes,
France
Title:The
neuroimmune biology of growth and lactogenic hormones.
24
Invited
Lecture:
Symposium
on Neuroendocrine Immunology,
30th
anniversary of the Scientific Research Institute,
Free
University of Aguascalientes.
May
22, 2003
Aguascalientes,
Mexico.
Title:The
Immune Neuroendocrine Circuitry.
25
Invited
Lecture:
Institute
of Neurosciences.
May
27, 2003
Queretaro,
Mexico.
Title:The
Neuroimmune Biology of Prolactin.
26
Invited
Lecture:
Sixth
International Conference of the Polish Neuroscience Society.
July
16-19, 2003
Warsaw,
Poland.
Title:The
Neuroimmune Regulatory Network.
27
Invited
Lecture:
National
Institute of Allergy and Infectious Diseases.
May
14, 2004.
Lecture:
“ Immunocompetence and Immunoconversion. Is fever benevolent or harmful
to the host?”
28
Invited
Lecture:
Congresso
Nacionales de Ciencias Fiziol: gicas
Sept 2-3,2006
Queretaro,Mexico
Title: “Recent
Insights into Hypothalamic Immunoregulation.” Istvan Berczi, Andres Quintanar Stephano and Kalman Kovacs.
29
Invited
Lecture:
Proc VII. INSNIM Congress
April 24-27, 2008
Rio de Janeiro, Brazil
Title: Neuroimmune regulation during acute illness and healing. Istvan Berczi, Andres Quintanar
Stephano and Kalman Kovacs.
30
Invited
Lecture:
International Course on Natural Immunity and Infectious diseases.
August 25-Sept.2, 2008
University of Augascalientes, Augascalientes, Mexico
Title: The role of natural immunity in the neuroimmune regulatopy
system. Istvan Berczi,
Andres Quintanar Stephano and Kalman Kovacs.
31
Invited
Lecture:
International Symposium on "Interaction of the nervous and immune systems in health and disease"
June 16-19 2009,
Saint-Petersburg, Russia,
Title: Neuroimmune Regulation of Natural Immunity. Andres
Quintanar-Stephano, Kalman Kovacs, Istvan Berczi.
32
Invited
Lecture:
International Course on Natural Immunity and Infectious diseases.
August 30-Sept.10, 2010
University of Augascalientes, Augascalientes, Mexico.
Title: Immune Host Defense: The Entire Organism Fights for Survival
Istvan Berczi, Andres Quintanar Stephano and Kalman Kovacs.
Chairperson:
1
Symposium
held at the 24th meeting on: "Protides of Biological Fluids"
April
28 - May 1, 1976
Bruges,
Belgium
Topic:
"Tissue protein antigen."
2
Mid-Western
Autumn Immunology Conference
Nov.
6 - 8, 1977
Sheraton-Chicago
Hotel
Chicago,
Illinois, USA
Workshop
on: "Tumor Immunology II."
3
Poster
Discussion:
14th
International Cancer Congress
August
21 - 27, 1986
Budapest,
Hungary
Poster
Discussion: " Immunomodulation - Immunoregulation."
4
FASEB
Summer conference, "Neuroimmunomodulation"
June
26 - July 1, 1988
Copper
Mountain, Colorado, USA
Session
entitled:"Neuroimmunology of Host Defence and Autoimmunity."
5
First
International Conference on:" Neuroimmuno-modulation"
May
23 - 26, 1990
Florence,
Italy
Workshop
on: "Neuroimmunoregulatory Hormones."
6
4th
Naito Conference on: "Neuro-Immune-Endocrine Networks" Nov.
25 - 28, 1994
Symposium
on: "Signal Molecules and Receptors of Neuro-Immune-Endocine Networks
, Part
II."
7
Annual
meeting of : The Psychoneuroimmunology Research Society
April
17 - 21, 1996
Santa Monics, California, USA
Symposium
on: "Prolactin in Health and Disease."
8
Winnipeg
2000 Conference
June
12, 2000
Basic
Science Building, University of Manitoba
Winnipeg,
Manitoba, Canada
Workshop
for:" The creation of "The Canadian Network for Neuroimmune Biology
(CANIB)."
9
VIII
International Conference on Allergy, Immunology and Global Network.
April
21 - 24, 2002
Cannes,
France
Symposium
on: Psychoneuroimmunology and Problems of Rehabilitation. (Wed.
April 24, 12 -1:30 pm)
10
Symposium
on Neuroimmune Biology.
July
16-19, 2003
Warsaw, Poland.
Proc.
Sixth International Conference of the Polish Neuroscience Society
Organizer:
1
Satellite
symposium on:Hormones and Immunity under the
auspices
of the 6th International Congress of Immunology
July
4 - 5, 1986
Toronto,
Ontario, Canada
2
Hans
Selye Symposium:Advances in Psychoneuroimmunology, a
satellite
meeting to the 8th International Congress of Immunology
August
17 - 21, 1992
Budapest,
Hungary
3
Annual
meeting of the Psychoneuroimmunology Research Society
August
17 - 21, 1996
Santa
Monica, California, USA
Symposium
on: "Prolactin in Health and Disease"
4
Winnipeg
2000 Conference
June
9 -12, 2000
Basic
Science Building, University of Manitoba
Winnipeg,
Manitoba, Canada
Workshop
for:" The creation of "The Canadian Network for Neuroimmune Biology
" (CANIB)
Member
of the Scientific Advisory Board:
International
Conference on " Stress of Life". Stress and adaptation from
molecules to man." Budapest, Hungary, July 1 - 5, 1997
Editor
in Chief:
Neuroimmune
Biology, book series published by:
Elsevier
Science, Amsterdam, The Netherlands.
Member
of Editorial Board:
Journal
of Experimental and Clinical Cancer Research. Esole Sega, Editor. Published
in Rome, Italy, February 1982 - 1993
Special
study section for the merit review of research grant applications on: "Monoclonal
Antibody in Cancer Therapy"(NIH - NCI - DCT - BRMT - 81 - 5) "Momoclonal
Antibody in Animal Tumor Models" (NIH - NCI -DCT -BRMTG - 81 - 6) March
25 - 26, 1982
Biochemical
Endocrinology study section, NIH, Bethesda, Maryland, USA, June 3 -
5, 1987
Study
section on "Neurolab - Homeostasis" - judging NASA applications,
NIH, Bethesda, Maryland, USA, March 3 - 4, 1994
Outside
reviewer: Special Emphasis Panel: Human Immunology Centre of Excellence
(RFA A1 - 98 - 01) Bethesda, Maryland, USA, March 9 - 11, 1999
American
Institute of Biological Sciences: Judging grant applications for USAMRMC
1998 War veteran’s illness research program., Sterling, Virginia, July
1999
