ENTRY           MYHU  #type complete             
TITLE           myoglobin [validated] - human
ORGANISM        #formal_name Homo sapiens #common_name man
DATE            24-Apr-1984 #sequence_revision 12-Jul-1996 #text_change
                12-Jul-2004
ACCESSIONS      I53991; A90999; A93398; A90582; A90584; A02464
REFERENCE       I53991
   #authors     Akaboshi, E.
   #journal     Gene (1985) 33:241-249
   #title       Cloning of the human myoglobin gene.
   #cross-references MUID:85232026; PMID:2989088
   #accession   I53991
      ##status preliminary; translated from GB/EMBL/DDBJ
      ##molecule_type DNA
      ##residues 1-128,'E',130-154 ##label RES
      ##cross-references UNIPROT:P02144; UNIPARC:UPI000016AD31; GB:M14603;
                NID:g187582; PIDN:AAA59595.1; PID:g386872
REFERENCE       A90999
   #authors     Weller, P.; Jeffreys, A.J.; Wilson, V.; Blanchetot, A.
   #journal     EMBO J. (1984) 3:439-446
   #title       Organization of the human myoglobin gene.
   #cross-references MUID:84182508; PMID:6571704
   #accession   A90999
      ##molecule_type DNA
      ##residues 2-154 ##label WEL
      ##cross-references UNIPARC:UPI000012FB3D; GB:X00371; NID:g34607;
                PIDN:CAA25109.1; PID:g1235527
      ##note initiator Met not shown
REFERENCE       A93398
   #authors     Romero-Herrera, A.E.; Lehmann, H.
   #journal     Nature New Biol. (1971) 232:149-152
   #title       Primary structure of human myoglobin.
   #cross-references MUID:71291923; PMID:5285572
   #accession   A93398
      ##molecule_type protein
      ##residues 2-19,'IDPA',24-83,'Q',85-99,'VPI',103-154 ##label ROM
      ##cross-references UNIPARC:UPI00001738E0
      ##note this sequence has been revised in references A90582 and A90584
REFERENCE       A90582
   #authors     Romero-Herrera, A.E.; Lehmann, H.
   #journal     Biochim. Biophys. Acta (1971) 251:482-488
   #title       The myoglobin of primates. I. Hylobates agilis (gibbon).
   #accession   A90582
      ##molecule_type protein
      ##residues 20-23;84 ##label RO2
      ##cross-references UNIPARC:UPI000011EC2D; UNIPARC:UPI00001738E1
      ##note revision to human sequence
REFERENCE       A90584
   #authors     Romero-Herrera, A.E.; Lehmann, H.
   #journal     Biochim. Biophys. Acta (1972) 278:62-67
   #title       The myoglobin of primates. II. Pan troglodytes (chimpanzee).
   #cross-references MUID:73002055; PMID:4627044
   #accession   A90584
      ##molecule_type protein
      ##residues 100-102 ##label RO3
      ##cross-references UNIPARC:UPI00001738E2
      ##note revision to human sequence
REFERENCE       A30619
   #authors     Hubbard, S.R.; Hendrickson, W.A.; Lambright, D.G.; Boxer,
                S.G.
   #journal     J. Mol. Biol. (1990) 213:215-218
   #title       X-ray crystal structure of a recombinant human myoglobin
                mutant at 2.8 angstroms resolution.
   #cross-references MUID:90258028; PMID:2342104
   #contents    annotation; X-ray crystallography, 2.8 angstroms of
                engineered mutant with 46-Arg and 111-Ala expressed in
                Escherichia coli
GENETICS
   #gene        GDB:MB
      ##cross-references GDB:119378; OMIM:160000
   #map_position 22q12-22q12
   #introns     32/2; 106/3
FUNCTION
   #description binds molecular oxygen for intracellular storage and
                transport, primarily in muscle
CLASSIFICATION  #superfamily globin; globin homology
KEYWORDS        chromoprotein; heme; iron; metalloprotein; monomer; muscle;
                oxygen carrier
FEATURE
   2-154               #product myoglobin #status experimental #label MAT\
   3-148               #domain globin homology #label GLB\
   65                  #binding_site oxygen (His) (distal axial ligand)
                       #status experimental\
   94                  #binding_site heme iron (His) (proximal axial ligand)
                       #status experimental
SUMMARY         #length 154  #molecular-weight 17184  #checksum 7061
SEQUENCE
                 5        10        15        20        25        30
       1 M G L S D G E W Q L V L N V W G K V E A D I P G H G Q E V L
      31 I R L F K G H P E T L E K F D K F K H L K S E D E M K A S E
      61 D L K K H G A T V L T A L G G I L K K K G H H E A E I K P L
      91 A Q S H A T K H K I P V K Y L E F I S E C I I Q V L Q S K H
     121 P G D F G A D A Q G A M N K A L E L F R K D M A S N Y K E L
     151 G F Q G