Hélène Perreault
Professor

Chemistry Department

University of Manitoba

Room 517 Parker Building            POST-DOCTORAL POSITION AVAILABLE
Tel (204) 474-7418
Fax (204) 474-7608
E-mail perreau@cc.umanitoba.ca 

                                                           


RESEARCH INTERESTS

Bioanalytical Chemistry

Proteins play very important roles in all types of organisms. They can act as enzymes, catalysts, oxygen carriers, structure building blocks, among many other possible roles. Normal protein function results of a combination of amino acid sequence, 3-D structure and sometimes aggregation with other proteins or biomolecules. If sequence (thus often structure) is altered, protein function changes, possibly causing diseases or other problems.

Over the past fifteen years, we have been interested in characterizing modified proteins from several sources, using mass spectrometry as our main analytical tool. Because proteins in cells always occur in very complex mixtures, preliminary steps such as electrophoresis and chromatography are often required in sample preparation. The mass spectrometers in our laboratory are equipped with a range of ionization methods, e.g. electrospray (ES) and matrix-assisted laser desorption/ionization (MALDI). Our research group now counts four graduate students, a technician and a research associate. See a list or recent publications below.

We have projects on the characterization of antibodies and other glycoproteins, We work in collaboration with medical researchers, microbiologists, biochemists and industry researchers. We also analyze samples as a service to our Department and to the scientific community and are part of the MabNet Monoclonal Antiboby Network sponsored by NSERC.

 


TEACHING: Bioanalytical Chemistry

CHEM 1000, Understanding the World through Chemistry: This is a half-year, 3 credit-hour fall course. Visit the course web site for schedule and content.

 

CHEM 4590, Advances Bioanalytical Chemistry: This is a half-year, 3 credit-hour winter-spring course. Visit the course web site for a tentative course schedule.

 

 


RESEARCH PUBLICATIONS: click here


Chemistry Department page