H CROG050101 D Substitution matrix computed from the Dirichlet Mixture Model (Crooks-Brenner, 2005) R PMID:15531614 A Crooks, G.E. and Brenner, S.E. T An alternative model of amino acid replacement J Bioinformatics 21, 975-980 (2005) M rows = ARNDCQEGHILKMFPSTWYV, cols = ARNDCQEGHILKMFPSTWYV 4 -2 6 -2 -1 7 -2 -1 1 7 0 -4 -3 -4 12 -1 1 0 0 -3 6 -1 0 0 1 -4 1 5 -1 -3 -1 -1 -3 -2 -2 7 -2 0 0 -1 -3 0 -1 -2 9 -2 -3 -5 -6 -1 -3 -4 -6 -3 5 -2 -3 -4 -5 -2 -3 -4 -5 -3 2 5 -2 2 0 0 -4 1 1 -2 -1 -4 -3 5 -1 -2 -3 -4 -1 -2 -3 -4 -2 1 2 -2 7 -2 -3 -4 -5 -2 -3 -4 -5 -1 0 1 -4 1 7 -1 -2 -2 -1 -3 -1 -1 -2 -2 -4 -3 -1 -3 -3 8 0 -1 0 0 -2 0 -1 -1 -1 -4 -3 -1 -2 -3 -1 4 -1 -1 -1 -1 -1 -1 -1 -2 -1 -2 -2 -1 -1 -2 -2 1 5 -3 -2 -3 -4 -2 -2 -3 -4 0 -1 -1 -3 0 3 -3 -3 -2 12 -2 -2 -2 -3 -2 -2 -3 -4 0 -1 -1 -3 0 3 -3 -2 -2 3 8 -1 -3 -4 -5 0 -3 -4 -5 -3 3 1 -3 1 0 -3 -3 -1 -2 -2 5 //