H KANM000101 D Substitution matrix (OPTIMA) derived by maximizing discrimination between homologs and non-homologs (Kann et al., 2000) R PMID:11056037 A Kann, M., Qian, B. and Goldstein, R.A. T Optimization of a new score function for the detection of remote homologs J Proteins: Structure, Function, and Genetics 41, 498-503 (2000) M rows = ARNDCQEGHILKMFPSTWYV, cols = ARNDCQEGHILKMFPSTWYV 36 -9 56 -19 4 59 -20 -18 18 65 6 -29 -30 -30 99 -3 12 2 2 -30 46 -10 3 3 20 -39 19 40 4 -18 7 -10 -29 -20 -23 67 -19 3 12 -7 -29 3 2 -18 86 -5 -28 -32 -34 -6 -30 -33 -41 -28 35 -7 -20 -32 -43 -6 -23 -31 -42 -27 28 32 -10 31 1 -4 -29 15 14 -18 -7 -31 -21 37 -9 -10 -19 -30 -8 1 -21 -30 -19 12 24 -12 51 -19 -30 -29 -33 -18 -29 -32 -32 -8 8 17 -29 2 57 -5 -18 -17 -7 -30 -11 -7 -18 -18 -30 -33 -10 -21 -39 74 12 -11 10 4 -10 0 -1 2 -9 -20 -22 3 -10 -19 -8 36 0 -8 0 -10 -7 -7 -6 -17 -20 -8 -13 -8 -7 -18 -11 18 48 -29 -29 -39 -40 -18 -19 -29 -19 -18 -28 -15 -30 -8 14 -38 -29 -19 110 -19 -15 -19 -20 -18 -9 -21 -29 20 -8 -2 -17 -9 37 -28 -19 -17 22 69 6 -32 -31 -31 -6 -19 -28 -30 -29 35 18 -23 10 0 -18 -22 6 -28 -9 38 //