H MUET020101 D Substitution matrix (VTML160) obtained by maximum likelihood estimation (Mueller et al., 2002) R PMID:11752185 A Mueller, T., Spang, R. and Vingron, M. T Estimating amino acid substitution models: A comparison of Dayhoff's estimator, the resolvent approach and a maximum likelihood method J Molecular Biology and Evolution 19, 8-13 (2002) M rows = ARNDCQEGHILKMFPSTWYV, cols = ARNDCQEGHILKMFPSTWYV 5 -2 7 -1 0 7 -1 -3 3 7 1 -3 -3 -5 13 -1 2 0 1 -4 6 -1 -1 0 3 -5 2 6 0 -3 0 -1 -2 -3 -2 8 -2 1 1 0 -2 2 -1 -3 9 -1 -4 -4 -6 -1 -4 -5 -7 -4 6 -2 -3 -4 -6 -4 -2 -4 -6 -3 3 6 -1 4 0 0 -4 2 1 -2 0 -4 -3 5 -1 -2 -3 -5 -1 -1 -3 -5 -3 2 4 -2 8 -3 -5 -5 -7 -4 -4 -6 -6 0 0 2 -5 1 9 0 -2 -2 -1 -3 -1 -1 -3 -2 -4 -3 -1 -4 -5 9 1 -1 1 0 1 0 0 0 -1 -3 -3 -1 -3 -3 0 4 1 -1 0 -1 0 -1 -1 -2 -1 -1 -2 -1 -1 -3 -1 2 5 -5 -4 -5 -7 -7 -6 -7 -5 -1 -2 -1 -5 -4 3 -5 -4 -6 16 -3 -3 -2 -5 -1 -4 -3 -5 3 -2 -1 -3 -2 6 -6 -2 -3 4 10 0 -4 -4 -4 1 -3 -3 -5 -3 4 2 -3 1 -1 -3 -2 0 -5 -3 5 //