H MUET020102 D Substitution matrix (VTML250) obtained by maximum likelihood estimation (Mueller et al., 2002) R 11752185 A Mueller, T., Spang, R. and Vingron, M. T Estimating amino acid substitution models: A comparison of Dayhoff's estimator, the resolvent approach and a maximum likelihood method J Molecular Biology and Evolution 19, 8-13 (2002) M rows = ARNDCQEGHILKMFPSTWYV, cols = ARNDCQEGHILKMFPSTWYV 2 -1 5 0 0 4 0 -1 2 5 1 -2 -1 -3 11 0 2 1 1 -2 3 0 0 1 3 -3 2 4 1 -1 0 0 -1 -1 -1 7 -1 1 1 0 -1 1 0 -1 6 -1 -2 -3 -4 0 -2 -3 -4 -2 4 -1 -2 -3 -4 -2 -2 -3 -4 -2 3 4 -1 3 1 0 -2 2 1 -1 0 -2 -2 3 -1 -1 -2 -3 0 -1 -2 -3 -2 2 3 -1 4 -2 -3 -3 -5 -2 -2 -4 -4 0 1 2 -3 1 7 0 -1 -1 0 -2 0 0 -1 -1 -3 -2 0 -2 -3 7 1 0 1 0 1 0 0 0 0 -2 -2 0 -1 -2 0 2 1 -1 0 0 0 0 0 -1 0 0 -1 0 0 -2 0 1 3 -3 -3 -4 -5 -4 -4 -5 -4 0 -1 0 -3 -2 3 -3 -3 -4 14 -2 -2 -1 -3 0 -2 -2 -4 2 -1 0 -2 -1 5 -4 -1 -2 4 8 0 -2 -2 -3 1 -2 -2 -3 -2 3 2 -2 2 0 -2 -1 0 -3 -1 3 //