/* HydroAlgorithm.java * * created: Wed Dec 16 1998 * * This file is part of Artemis * * Copyright (C) 1998,1999,2000 Genome Research Limited * * This program is free software; you can redistribute it and/or * modify it under the terms of the GNU General Public License * as published by the Free Software Foundation; either version 2 * of the License, or (at your option) any later version. * * This program is distributed in the hope that it will be useful, * but WITHOUT ANY WARRANTY; without even the implied warranty of * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * GNU General Public License for more details. * * You should have received a copy of the GNU General Public License * along with this program; if not, write to the Free Software * Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA. * * $Header: //tmp/pathsoft/artemis/uk/ac/sanger/artemis/plot/HydroAlgorithm.java,v 1.2 2005-09-06 07:23:15 tjc Exp $ */ package uk.ac.sanger.artemis.plot; import uk.ac.sanger.artemis.*; import uk.ac.sanger.artemis.io.Range; import uk.ac.sanger.artemis.sequence.Bases; /** * This is the base class for HydrophobicityAlgorithm and * HydrophilicityAlgorithm. * * @author Kim Rutherford * @version $Id: HydroAlgorithm.java,v 1.2 2005-09-06 07:23:15 tjc Exp $ **/ public abstract class HydroAlgorithm extends FeatureAlgorithm { /** * Create a new HydroAlgorithm object. * @param feature The feature to do future calculation on. * @param algorithm_name A String used to identify this algorithm to the * user. * @param data_array An array of data values, one value for each amino acid. * The data should correspond to the amino acids in this order: * RKDQNEHSTPYCGAMWLVFI. **/ public HydroAlgorithm (final Feature feature, final String algorithm_name, final String algorithm_short_name, final float [] data_array) { super (feature, algorithm_name, algorithm_short_name); this.data_array = data_array; } /** * Return the hydrophobicity between a pair of amino acids. * @param start The start amino acid (included in the range), indexed from * zero. * @param end The end amino acid (included in the range), indexed from 0. * @param values The one return value for this algorithm is returned in * this array. **/ public void getValues (int start, int end, float [] values) { final String translation = getFeature().getTranslation().toString().substring(start, end).toLowerCase(); // System.out.println(translation+" "+start + " " + end + " " + // getFeature ().getTranslation ().length ()); float total = 0; for (int i = 0 ; i < translation.length () ; ++i) { total += getCodonValue (data_array, translation.charAt (i)); } values[0] = total / translation.length (); // System.out.println("foo: " + values[0] + " " + total + " " + // translation.length ()); } /** * Return the default or optimal window size. * @return null is returned if this algorithm doesn't have optimal window * size. **/ public Integer getDefaultWindowSize () { final Integer super_window_size = super.getDefaultWindowSize (); if (super_window_size != null) { // the superclass version of getDefaultWindowSize () returns non-null // iff the user has set the window size in the options file return super_window_size; } return new Integer (7); } /** * Return the default maximum window size for this algorithm. * @return null is returned if this algorithm doesn't have maximum window * size. **/ public Integer getDefaultMaxWindowSize () { final Integer super_max_window_size = super.getDefaultMaxWindowSize (); if (super_max_window_size != null) { // the superclass version of getDefaultMaxWindowSize () returns non-null // iff the user has set the max window size in the options file return super_max_window_size; } return new Integer (100); } /** * Return the default minimum window size for this algorithm. * @return null is returned if this algorithm doesn't have minimum window * size. **/ public Integer getDefaultMinWindowSize () { final Integer super_min_window_size = super.getDefaultMinWindowSize (); if (super_min_window_size != null) { // the superclass version of getDefaultMinWindowSize () returns non-null // iff the user has set the minimum window size in the options file return super_min_window_size; } return new Integer (7); } /** * Return the default or optimal step size. * @return null is returned if this algorithm doesn't have optimal step * size. **/ public Integer getDefaultStepSize (int window_size) { return new Integer (1); } /** * Return the average value of function over the whole strand. * @return null is returned if this algorithm doesn't have an average or if * the average can't be calculated. **/ public Float getAverage () { return new Float (0); } /** * Return the value in data_array that corresponds to the given amino acid * symbol (uses amino_acid_array to do this). **/ private float getCodonValue (float [] data_array, char amino_acid_symbol) { final int index = amino_acid_array.indexOf (amino_acid_symbol); // System.out.println("getCodonValue (): " + index + " " + // amino_acid_symbol) ; // + " " + data_array[index]); if (index == -1) { // return the average value in this case. return 0; } else { return data_array[index]; } } /** * Data values for each amino acid. This array is indexed by comparing to * amino_acid_array. **/ /* final */ private float [] data_array; /** * The index of the amino acid symbol in this String gives the index to * look up in data_array to get the hydrophobicity value. eg. the symbol * "r" has index 0 hence has value +3.00 **/ private final static String amino_acid_array = "rkdqnehstpycgamwlvfi"; }