#!/bin/sh -

# this script will run a search program on a sequence input file or on each
# file in a file of filenames

# to customise this script see the function called run_one_prog below


RCS_HEADER="$Header: //tmp/pathsoft/artemis/etc/run_hth,v 1.1 2004-06-09 10:03:06 tjc Exp $"

PROG=`echo $RCS_HEADER | sed 's/.*run_\(.*\),v.*/\1/'`


if [ $# = 4 -a x$1 = x-onefile ]
then
    shift
    ONEFILE=t
    PARAMETERS=$3 export PARAMETERS
else
    if [ $# = 2 ]
    then
        PARAMETERS=$2 export PARAMETERS
    else
        echo usage: $0 -onefile input_file output_file parameters 1>&2
        echo    or: $0 file_of_filenames parameters 1>&2
        exit 1
    fi
fi


# expand any ~ or environment variables
EXPANDED_PARAMETERS=`echo "echo $PARAMETERS" | /bin/csh -f`


### change this function to suit your site:

run_one_prog () {
    INPUT_FILE=$1
    OUTPUT_FILE=$2
    PARAMETERS=$3


    ### change these lines:
    EXEC=helixturnhelix

    echo "about to start $EXEC with input from $INPUT_FILE and output to" 1>&2
    echo "$OUTPUT_FILE using database $PARAMETERS" 1>&2
    echo "command line: $EXEC $PARAMETERS $INPUT_FILE" 1>&2

    $EXEC $INPUT_FILE $OUTPUT_FILE $PARAMETERS 2> hth_errors.new

    # add/change the flags to suit your site:
    $EXEC $INPUT_FILE -outfile $OUTPUT_FILE $PARAMETERS 2>&1 | 
      tee ${PROG}_errors.new 1>&2

    #### end of changes


    if [ -s ${PROG}_errors.new ]
    then
        ( echo ERROR running $PROG: ; echo; 
          echo ===================================================
          cat ${PROG}_errors.new ) >> $OUTPUT_FILE
        cat ${PROG}_errors.new >> ${PROG}_errors
    fi
}

(echo "#!/bin/sh -"; echo "kill $$") > $PROG.kill

chmod a+x $PROG.kill

if [ x$ONEFILE = x ]
then
    for i in `cat $1`
    do
        run_one_prog $i $i.out $EXPANDED_PARAMETERS
    done

else
    run_one_prog $1 $2 $EXPANDED_PARAMETERS
fi

if [ x$ONEFILE = x ]
then
    PEPFILES=`cat $1`
else
    PEPFILES=$1
fi

if [ -e hth/hth.tab ]
then
    mv -f hth/hth.tab hth/hth.tab.old
fi

for i in $PEPFILES
do
# write a tab file containing a feature for each hth
perl -e '
open PEPFILE, "$ARGV[0]" or die "$0: cannot open $ARGV[0]\n";

my $first_line = <PEPFILE>;

close PEPFILE;

if ($first_line !~ m/^>(.*?), (.*) (\d+):(\d+)\s+(\S+)/) {
  die "first line of $ARGV[0] is badly formatted\n";
}

my ($gene_name, $description, $pep_first_base,
    $pep_last_base, $forward_or_back) = ($1, $2, $3, $4, $5);

open HTHFILE, "$ARGV[1]" or die "$0: cannot open $ARGV[1]\n";

my $score;
my $first_match_base;

while (<HTHFILE>) {
  if (m/^Score (\d+) .* in .* at residue (\d+)/) {
    $score = $1;
    $first_match_base = $2;
  }

  if (m/^\s+Sequence:\s+(\S+)/ && 
      defined ($score) && defined ($pep_first_base)) {
    if ($forward_or_back eq "forward") {
      my $start_base = $pep_first_base + ($first_match_base - 1) * 3;
      my $end_base = $start_base + (length $1) * 3 - 1;
      print <<EOF;
FT   CDS_motif       $start_base..$end_base
FT                   /note="Helix-turn-helix from $gene_name score $score"
FT                   /label=hth
EOF
    } else {
      my $end_base = $pep_last_base - ($first_match_base - 1) * 3;
      my $start_base = $end_base - ((length $1) * 3 - 1);
      print <<EOF;
FT   CDS_motif       complement($start_base..$end_base)
FT                   /note="Helix-turn-helix from $gene_name score $score"
FT                   /label=hth
EOF
    }
  }
}
' $i $i.out >> hth/hth.tab

done

exit 0