This file is a Amino-acid similarity file for use with BOX. This file is used in colouring residues that are "similar" to a single consensus residue. Similarities contained in this file are not automatically set-forming. This means: The line I LVM means that I is similar to L,V and M and also that L,V,M are similar to I. It does not imply that L is similar to V or to M. For achieving this, more lines (the next ones) are necessary. Although is seems weird, this feature has been chosen DELIBERATELY because I think it could be helpful in some cases. This table was taken from ClustalX v1.3b: WEAK groups: These are all the positively scoring groups that occur in the Gonnet Pam250 matrix .. F YW Y WF W FY C SA S AC A CS A TV T VA V AT S AG A GS G SA S TNK T NKS N KST K STN S TPA T PAS P AST A STP S GND G NDS N DSG D SGN S NDEQK N DEQKS D EQKSN E QKSND Q KSNDE K SNDEQ N DEQHK D EQHKN E QHKND Q HKNDE H KNDEQ K NDEQH N EQHRK E QHRKN Q HRKNE H RKNEQ R KNEQH K NEQHR F VLIM V LIMF L IMFV I MFVL M FVLI H FY F YH Y HF