cd ~
perl -MNet::FTP -e \
  '$ftp = new Net::FTP("ftp.ncbi.nlm.nih.gov", Passive => 1); $ftp->login;
   $ftp->binary; $ftp->get("/entrez/entrezdirect/edirect.zip");'
unzip -u -q edirect.zip
rm edirect.zip
export PATH=$PATH:$HOME/edirect
./edirect/setup.sh