ID 1A02_HUMAN STANDARD; PRT; 365 AA.
AC P01892; P06338; P30514; P30444; P30445; P30446; Q29680; Q29899;
AC Q95352; Q29837; Q95380;
DT 21-JUL-1986 (Rel. 01, Created)
DT 13-AUG-1987 (Rel. 05, Last sequence update)
DT 15-FEB-2000 (Rel. 39, Last annotation update)
DE HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN PRECURSOR.
GN HLA-A OR HLAA.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A. (A*0201).
RX MEDLINE; 85132727.
RA Koller B.H., Orr H.T.;
RT "Cloning and complete sequence of an HLA-A2 gene: analysis of two
RT HLA-A alleles at the nucleotide level.";
RL J. Immunol. 134:2727-2733(1985).
RN [2]
RP SEQUENCE FROM N.A. (A*0201).
RX MEDLINE; 89122144.
RA Cianetti L., Testa U., Scotto L., la Valle R., Simeone A.,
RA Boccoli G., Giannella G., Peschle C., Boncinelli E.;
RT "Three new class I HLA alleles: structure of mRNAs and alternative
RT mechanisms of processing.";
RL Immunogenetics 29:80-91(1989).
RN [3]
RP SEQUENCE FROM N.A. (A*0201).
RX MEDLINE; 90207291.
RA Ennis P.D., Zemmour J., Salter R.D., Parham P.;
RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain
RT reaction: frequency and nature of errors produced in amplification.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990).
RN [4]
RP SEQUENCE FROM N.A. (A*0201/A*0211/A*0212).
RX MEDLINE; 92269955.
RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J.,
RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
RT "Unusual HLA-B alleles in two tribes of Brazilian Indians.";
RL Nature 357:326-329(1992).
RN [5]
RP SEQUENCE OF 39-365 FROM N.A. (A*0201).
RX MEDLINE; 85230571.
RA Krangel M.S.;
RT "Unusual RNA splicing generates a secreted form of HLA-A2 in a
RT mutagenized B lymphoblastoid cell line.";
RL EMBO J. 4:1205-1210(1985).
RN [6]
RP SEQUENCE OF 25-295 (A*0201).
RX MEDLINE; 80056745.
RA Orr H.T., Lopez de Castro J.A., Parham P., Ploegh H.L.,
RA Strominger J.L.;
RT "Comparison of amino acid sequences of two human histocompatibility
RT antigens, HLA-A2 and HLA-B7: location of putative alloantigenic
RT sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:4395-4399(1979).
RN [7]
RP REVISIONS (A*0201).
RX MEDLINE; 82247941.
RA Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.;
RT "Structure of crossreactive human histocompatibility antigens HLA-A28
RT and HLA-A2: possible implications for the generation of HLA
RT polymorphism.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982).
RN [8]
RP SEQUENCE OF 26-298 FROM N.A. (A*0202/A*0203).
RX MEDLINE; 87306734.
RA Mattson D.H., Handy D.E., Bradley D.A., Coligan J.E., Cowan E.P.,
RA Biddison W.E.;
RT "DNA sequences of the genes that encode the CTL-defined HLA-A2
RT variants M7 and DK1.";
RL Immunogenetics 26:190-192(1987).
RN [9]
RP SEQUENCE FROM N.A. (A*0203/A*0205).
RX MEDLINE; 87252273.
RA Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.;
RT "Multiple genetic mechanisms have contributed to the generation of
RT the HLA-A2/A28 family of class I MHC molecules.";
RL J. Immunol. 139:936-941(1987).
RN [10]
RP SEQUENCE FROM N.A. (A*0203/A*0205).
RA Domena J.D.;
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP SEQUENCE OF 9-365 FROM N.A. (A*0204).
RX MEDLINE; 92039809.
RA Castano A.R., Lopez de Castro J.A.;
RT "Structure of the HLA-A*0204 antigen, found in South American
RT Indians. Spatial clustering of HLA-A2 subtype polymorphism.";
RL Immunogenetics 34:281-285(1991).
RN [12]
RP SEQUENCE OF 9-365 FROM N.A. (A*0204).
RX MEDLINE; 92269956.
RA Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L.,
RA Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H.,
RA Troup G.M., Hughes A.L., Letvin N.L.;
RT "New recombinant HLA-B alleles in a tribe of South American
RT Amerindians indicate rapid evolution of MHC class I loci.";
RL Nature 357:329-333(1992).
RN [13]
RP SEQUENCE FROM N.A. (A*0206).
RX MEDLINE; 89235215.
RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.;
RT "Diversity and diversification of HLA-A,B,C alleles.";
RL J. Immunol. 142:3937-3950(1989).
RN [14]
RP PARTIAL SEQUENCE (A*0206).
RX MEDLINE; 86305811.
RA Ezquerra A., Domenech N., van der Poel J., Strominger J.L., Vega M.A.,
RA Lopez de Castro J.A.;
RT "Molecular analysis of an HLA-A2 functional variant CLA defined by
RT cytolytic T lymphocytes.";
RL J. Immunol. 137:1642-1649(1986).
RN [15]
RP PARTIAL SEQUENCE (A*0207).
RX MEDLINE; 88113844.
RA Domenech N., Ezquerra A., Castano R., Lopez de Castro J.A.;
RT "Structural analysis of HLA-A2.4 functional variant KNE. Implications
RT for the mapping of HLA-A2-specific T-cell epitopes.";
RL Immunogenetics 27:196-202(1988).
RN [16]
RP PARTIAL SEQUENCE (A*0208).
RX MEDLINE; 88314183.
RA Domenech N., Castano R., Goulmy E., Lopez de Castro J.A.;
RT "Molecular analysis of HLA-A2.4 functional variant KLO: close
RT structural and evolutionary relatedness to the HLA-A2.2 subtype.";
RL Immunogenetics 28:143-152(1988).
RN [17]
RP PARTIAL SEQUENCE (A*0209).
RX MEDLINE; 88186100.
RA Castano R., Ezquerra A., Domenech N., Lopez de Castro J.A.;
RT "An HLA-A2 population variant with structural polymorphism in the
RT alpha 3 region.";
RL Immunogenetics 27:345-355(1988).
RN [18]
RP SEQUENCE FROM N.A. (A*0210).
RX MEDLINE; 89122133.
RA Epstein H., Kennedy L., Holmes N.;
RT "An Oriental HLA-A2 subtype is closely related to a subset of
RT Caucasoid HLA-A2 alleles.";
RL Immunogenetics 29:112-116(1989).
RN [19]
RP SEQUENCE OF 9-365 FROM N.A. (A*0211).
RX MEDLINE; 92218010.
RA Castano A.R., Lopez de Castro J.A.;
RT "Structure of the HLA-A*0211 (A2.5) subtype: further evidence for
RT selection-driven diversification of HLA-A2 antigens.";
RL Immunogenetics 35:344-346(1992).
RN [20]
RP SEQUENCE FROM N.A. (A*0213).
RX MEDLINE; 94222455.
RA Barber D.F., Fernandez J.M., Lopez de Castro J.A.;
RT "Primary structure of a new HLA-A2 subtype: HLA-A*0213.";
RL Immunogenetics 39:378-378(1994).
RN [21]
RP SEQUENCE FROM N.A. (A*0216).
RX MEDLINE; 95278976.
RA Barouch D., Krausa P., Bodmer J., Browning M.J., McMichael A.J.;
RT "Identification of a novel HLA-A2 subtype, HLA-A*0216.";
RL Immunogenetics 41:388-388(1995).
RN [22]
RP SEQUENCE FROM N.A. (A*0217).
RC TISSUE=BLOOD;
RX MEDLINE; 95381236.
RA Selvakumar A., Granja C.B., Salazar M., Alosco S.M., Yunis E.J.,
RA Dupont B.;
RT "A novel subtype of A2 (A*0217) isolated from the South American
RT Indian B-cell line AMALA.";
RL Tissue Antigens 45:343-347(1995).
RN [23]
RP SEQUENCE FROM N.A. (A*0218).
RC TISSUE=BLOOD;
RA Kashiwase K., Tokunaga K., Ishikawa Y., Oohashi H., Hashimoto M.,
RA Akaza T., Tadokoro K., Juji T.;
RT "A new A2 sequence HLA-A2K from Japanese.";
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [24]
RP SEQUENCE FROM N.A. (A*0220).
RC TISSUE=BLOOD;
RX MEDLINE; 97161038.
RA Fleischhauer K., Zino E., Mazzi B., Severini G.M., Benazzi E.,
RA Bordignon C.;
RT "HLA-A*02 subtype distribution in Caucasians from northern Italy:
RT identification of A*0220.";
RL Tissue Antigens 48:673-679(1996).
RN [25]
RP SEQUENCE FROM N.A. (A*0221).
RC TISSUE=BLOOD;
RA Szmania S., Baxter-Lowe L.A.;
RT "Nucleotide sequence of a novel HLA-A2 gene.";
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [26]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF A*0201.
RX MEDLINE; 88014204.
RA Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S.,
RA Strominger J.L., Wiley D.C.;
RT "Structure of the human class I histocompatibility antigen, HLA-A2.";
RL Nature 329:506-512(1987).
RN [27]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A*0201.
RX MEDLINE; 91245570.
RA Saper M.A., Bjorkman P.J., Wiley D.C.;
RT "Refined structure of the human histocompatibility antigen HLA-A2 at
RT 2.6-A resolution.";
RL J. Mol. Biol. 219:277-319(1991).
CC -!- FUNCTION: INVOLVED IN THE PRESENTATION OF FOREIGN ANTIGENS TO
CC THE IMMUNE SYSTEM.
CC -!- SUBUNIT: DIMER OF ALPHA CHAIN AND A BETA CHAIN (BETA-2-
CC MICROGLOBULIN).
CC -!- POLYMORPHISM: THE FOLLOWING ALLELES OF A-2 ARE KNOWN: A*0201,
CC A*0202, A*0203, A*0204, A*0205, A*0206 (A2.4A), A*0207, A*0208,
CC A*0209, A*0210, A*0211 (A2.5), A*0212, A*0213 (A*02SLU), A*0216,
CC A*0217, A*0218 (A2K), A*0219, A*0220 AND A*0221. THE SEQUENCE
CC SHOWN IS THAT OF A*0201.
CC -!- CAUTION: REF.6 AND REF.7 SEQUENCES DIFFER FROM THAT SHOWN
CC EXTENSIVELY.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
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DR EMBL; K02883; AAA98727.1; -.
DR EMBL; M84379; AAA59606.1; -.
DR EMBL; X02457; CAA26297.1; -.
DR EMBL; M19670; AAA03683.1; -.
DR EMBL; M17690; AAB02120.1; -.
DR EMBL; U03863; AAA03604.1; -.
DR EMBL; M86404; -; NOT_ANNOTATED_CDS.
DR EMBL; X57954; CAA41022.1; ALT_SEQ.
DR EMBL; U03862; AAA03603.1; -.
DR EMBL; M24042; AAA59653.1; -.
DR EMBL; Z23071; CAA80612.1; -.
DR EMBL; M84377; AAA59603.1; -.
DR EMBL; X60764; -; NOT_ANNOTATED_CDS.
DR EMBL; M84378; AAA59604.1; -.
DR EMBL; Z27120; CAA81644.1; -.
DR EMBL; Z46633; CAA86602.1; -.
DR EMBL; U18930; AAA87076.1; -.
DR EMBL; D83515; BAA11935.1; -.
DR EMBL; X96724; CAA65501.1; -.
DR EMBL; U56825; AAB17465.1; -.
DR PIR; A02188; HLHUA2.
DR PIR; A02191; HLHU2A.
DR PIR; E35997; E35997.
DR PIR; S19020; S19020.
DR PIR; S23593; S23593.
DR PDB; 1HLA; 15-JUL-90.
DR PDB; 3HLA; 15-APR-90.
DR PDB; 1HHG; 31-OCT-93.
DR PDB; 1HHH; 31-OCT-93.
DR PDB; 1HHI; 31-OCT-93.
DR PDB; 1HHJ; 31-OCT-93.
DR PDB; 1HHK; 31-OCT-93.
DR PDB; 1AQD; 28-JAN-98.
DR MIM; 142800; -.
DR PROSITE; PS00290; IG_MHC; 1.
DR PFAM; PF00047; ig; 1.
DR PFAM; PF00129; MHC_I; 1.
KW MHC I; Transmembrane; Glycoprotein; Signal; Polymorphism;
KW 3D-structure.
FT SIGNAL 1 24
FT CHAIN 25 365 HLA CLASS I HISTOCOMPATIBILITY ANTIGEN,
FT A-2 ALPHA CHAIN.
FT DOMAIN 25 114 EXTRACELLULAR ALPHA-1.
FT DOMAIN 115 206 EXTRACELLULAR ALPHA-2.
FT DOMAIN 207 298 EXTRACELLULAR ALPHA-3.
FT DOMAIN 299 308 CONNECTING PEPTIDE.
FT TRANSMEM 309 332
FT DOMAIN 333 365 CYTOPLASMIC TAIL.
FT CARBOHYD 110 110
FT DISULFID 125 188
FT DISULFID 227 283
FT STRAND 27 36
FT STRAND 45 52
FT TURN 53 54
FT STRAND 55 61
FT TURN 62 63
FT STRAND 70 71
FT HELIX 74 76
FT TURN 77 78
FT HELIX 81 108
FT TURN 109 110
FT TURN 113 114
FT STRAND 118 127
FT TURN 129 130
FT STRAND 133 142
FT TURN 143 144
FT STRAND 145 150
FT TURN 152 153
FT STRAND 157 159
FT TURN 163 163
FT HELIX 164 173
FT TURN 174 175
FT HELIX 176 185
FT TURN 186 186
FT HELIX 187 198
FT TURN 199 199
FT HELIX 200 203
FT TURN 204 204
FT STRAND 207 207
FT STRAND 210 219
FT TURN 220 221
FT STRAND 222 233
FT STRAND 238 243
FT TURN 244 245
FT STRAND 246 247
FT HELIX 249 251
FT STRAND 253 254
FT STRAND 258 259
FT STRAND 265 274
FT TURN 275 276
FT HELIX 278 280
FT STRAND 281 286
FT TURN 288 289
FT STRAND 294 297
FT VARIANT 33 33 F -> Y (IN A*0205, A*0206, A*0208, A*0210
FT AND A*0221).
FT /FTId=VAR_004334.
FT VARIANT 54 54 D -> N (IN A*0221).
FT /FTId=VAR_004335.
FT VARIANT 67 67 Q -> R (IN A*0202, A*0205, AND A*0208).
FT /FTId=VAR_004336.
FT VARIANT 90 90 K -> N (IN A*0208 AND A*0220).
FT /FTId=VAR_004337.
FT VARIANT 97 98 TH -> ID (IN A*0211).
FT /FTId=VAR_004338.
FT VARIANT 119 119 V -> L (IN A*0202, A*0205, A*0208 AND
FT A*0217).
FT /FTId=VAR_004339.
FT VARIANT 121 121 R -> M (IN A*0204 AND A*0217).
FT /FTId=VAR_004340.
FT VARIANT 123 123 Y -> C (IN A*0207 AND A*0218).
FT /FTId=VAR_004341.
FT VARIANT 123 123 Y -> F (IN A*0210 AND A*0217).
FT /FTId=VAR_004342.
FT VARIANT 131 131 W -> G (IN A*0210).
FT /FTId=VAR_004343.
FT VARIANT 162 162 M -> K (IN A*0218).
FT /FTId=VAR_004344.
FT VARIANT 173 173 A -> T (IN A*0203).
FT /FTId=VAR_004345.
FT VARIANT 176 176 V -> E (IN A*0203 AND A*0213).
FT /FTId=VAR_004346.
FT VARIANT 180 180 L -> W (IN A*0202, A*0203, A*0205 AND
FT A*0208).
FT /FTId=VAR_004347.
FT VARIANT 180 180 L -> Q (IN A*0212 AND A*0213).
FT /FTId=VAR_004348.
FT VARIANT 187 187 T -> E (IN A*0216).
FT /FTId=VAR_004349.
FT VARIANT 260 260 A -> E (IN A*0209).
FT /FTId=VAR_004350.
SQ SEQUENCE 365 AA; 40922 MW; B54A97B24B337C08 CRC64;
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ
RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL
RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL
TACKV
//