application: msbar [
  documentation: "Mutate a sequence"
  groups: "Nucleic:Mutation, Protein:Mutation"
    relations: "EDAM:0000091 topic Data handling"
    relations: "EDAM:0000199 topic Mutation and polymorphism"
    relations: "EDAM:0000367 operation Sequence mutation and randomization"
]

section: input [
  information: "Input section"
  type: "page"
]

  seqall: sequence [
    parameter: "Y"
    type: "any"
    relations: "EDAM:0000849 data Sequence record"
  ]

  seqall: othersequence [
    type: "any"
    default: "asis:N"
    information: "Other sequences that the mutated result
                  should not match"
    help: "If you require that the resulting mutated sequence should
           not match a set of other sequences, then you can specify that set
           of sequences here. For example, if you require that the mutated
           sequence should not be the same as the input sequence, enter the
           input sequence here. If you want the result to be different to
           previous results of this program, specify the previous result
           sequences here. The program will check that the result does not
           match the sequences specified here before writing it out. If a
           match is found, then the mutation is started again with a fresh
           copy of the input sequence. If, after 10 such retries, there is
           still a match to the set of sequence given here, then the matching
           mutated sequence is written with a warning message."
    nullok: "Y"
    relations: "EDAM:0000849 data Sequence record"
  ]

endsection: input

section: required [
  information: "Required section"
  type: "page"
]

  integer: count [
    standard: "Y"
    default: "1"
    minimum: "0"
    information: "Number of times to perform the mutation
                  operations"
    relations: "EDAM:0001693 data Number of iterations"
  ]

  list: point [
    standard: "Y"
    default: "0"
    minimum: "1"
    maximum: "4"
    header: "Point mutation operations"
    values: "0:None; 1:Any of the following; 2:Insertions;
             3:Deletions; 4:Changes; 5:Duplications; 6:Moves"
    delimiter: ";"
    codedelimiter: ":"
    information: "Types of point mutations to perform"
    relations: "EDAM:0002527 data Parameter or primitive"
  ]

  list: block [
    standard: "Y"
    default: "0"
    minimum: "1"
    maximum: "4"
    header: "Block mutation operations"
    values: "0:None; 1:Any of the following; 2:Insertions;
             3:Deletions; 4:Changes; 5:Duplications; 6:Moves"
    delimiter: ";"
    codedelimiter: ":"
    information: "Types of block mutations to perform"
    relations: "EDAM:0002527 data Parameter or primitive"
  ]

  list: codon [
    standard: "@(!$(acdprotein))"
    default: "0"
    minimum: "1"
    maximum: "4"
    header: "Codon mutation operations"
    values: "0:None; 1:Any of the following; 2:Insertions;
             3:Deletions; 4:Changes; 5:Duplications; 6:Moves"
    delimiter: ";"
    codedelimiter: ":"
    information: "Types of codon mutations to perform"
    help: "Types of codon mutations to perform. These are only done if
           the sequence is nucleic."
    relations: "EDAM:0002527 data Parameter or primitive"
  ]

endsection: required

section: additional [
  information: "Additional section"
  type: "page"
]

  boolean: inframe [
    additional: "@(!$(acdprotein))"
    default: "N"
    information: "Do 'codon' and 'block' operations in frame"
    relations: "EDAM:0002527 data Parameter or primitive"
  ]

endsection: additional

section: advanced [
  information: "Advanced section"
  type: "page"
]

  integer: minimum [
    default: "1"
    minimum: "0"
    information: "Minimum size for a block mutation"
    relations: "EDAM:0001249 data Sequence length"
  ]

  integer: maximum [
    default: "10"
    minimum: "$(minimum)"
    information: "Maximum size for a block mutation"
    relations: "EDAM:0001249 data Sequence length"
  ]

endsection: advanced

section: output [
  information: "Output section"
  type: "page"
]

  seqoutall: outseq [
    parameter: "Y"
    relations: "EDAM:0000849 data Sequence record"
  ]

endsection: output