| AGT | enzyme | uniprot |
| REN | uniprot | |
| Angiotensin I | uniprot | |
| ACE | enzyme | |
| AGTR2 | uniprot | |
| KNG1 | uniprot | |
| ACE | enzyme | |
| NOS3 | uniprot | |
| Angiotensin II | uniprot | |
| AGTR1 | uniprot | |
| BDKRB2 | uniprot | |
| KNG1 | uniprot | |
| ACE Inhibitor | CHEBI:35457 | |
| Aldosterone | hmdbid:HMDB00037 | |
| Cell Membrane |
| PDHA1 | uniprot | |
| PDHA2 | uniprot | |
| PEMT | uniprot | |
| PCYT1A | uniprot | |
| CHKA | uniprot | |
| ACHE | uniprot | |
| CHAT | uniprot | |
| Phosphatidylethanolamine | chemical | |
| Phosphatidylcholine | hmdbid:HMDB02357 | |
| Glycerophosphocholine | hmdbid:HMDB00086 | |
| Choline | hmdbid:HMDB00097 | |
| Acetyl CoA | hmdbid:HMDB01206 | uniprot |
| Pyruvate from Glycolysis | ||
| Acetate | hmdbid:HMDB00042 | |
| Choline | hmdbid:HMDB00097 | |
| Phosphorylcholine | hmdbid:HMDB01565 | |
| Cytidine Diphosphate Choline | hmdbid:HMDB01413 | |
| Acetylcholine | hmdbid:HMDB00895 | |
| *Cytosol* | chemical | |
| *Synaptic Cleft* |
| IGF1 | uniprot | |
| PTGIS | uniprot | |
| PPARD | uniprot | |
| CREB1 | uniprot | |
| MIXL1 | ||
| GH1 | uniprot | |
| ID3 | uniprot | |
| WNT10B | uniprot | |
| STAT5A | uniprot | |
| STAT5B | uniprot | |
| DLK1 | uniprot | |
| NR3C1 | uniprot | |
| DDIT3 | uniprot | |
| LIF | uniprot | |
| CEBPB | uniprot | |
| CYP26A1 | uniprot | |
| CYP26B1 | uniprot | |
| RXRA | uniprot | |
| RARA | uniprot | |
| NR1H3 | uniprot | |
| LPL | enzyme | uniprot |
| SREBF1 | uniprot | |
| FAS | uniprot | |
| RBL1 | uniprot | |
| GATA3 | uniprot | |
| GATA2 | uniprot | |
| PPARG | uniprot | |
| MEF2A | uniprot | |
| MEF2B | uniprot | |
| MEF2C | uniprot | |
| MEF2D | uniprot | |
| ASIP | uniprot | |
| TNF | uniprot | |
| MIF | uniprot | |
| TGFB1 | uniprot | |
| SERPINE1 | uniprot | |
| SLC2A4 | uniprot | |
| SCD | uniprot | |
| TWIST1 | uniprot | |
| LEP | uniprot | |
| RETN | uniprot | |
| DF | ||
| GTF3A | uniprot | |
| RB1 | uniprot | |
| RBL2 | uniprot | |
| ADIPOQ | uniprot | |
| ADFP | uniprot | |
| AGT | enzyme | uniprot |
| CDKN1A | uniprot | |
| E2F1 | uniprot | |
| SP1 | uniprot | |
| HMGA1 | uniprot | |
| PLIN | uniprot | |
| IL6 | uniprot | |
| GADD45A | uniprot | |
| GADD45B | uniprot | |
| CEBPD | uniprot | |
| BMP1 | uniprot | |
| BMP2 | uniprot | |
| BMP3 | uniprot | |
| BMP4 | uniprot | |
| NDN | uniprot | |
| FOXO1A | uniprot | |
| KLF5 | uniprot | |
| FOXC2 | uniprot | |
| PPARGC1A | uniprot | |
| NCOA1 | uniprot | |
| NCOA2 | uniprot | |
| PPARA | uniprot | |
| STAT3 | uniprot | |
| STAT2 | uniprot | |
| STAT1 | uniprot | |
| STAT6 | uniprot | |
| SOCS1 | uniprot | |
| SOCS3 | uniprot | |
| CNTFR | uniprot | |
| LIFR | uniprot | |
| IL6ST | uniprot | |
| MBNL1 | uniprot | |
| OSM | uniprot | |
| CTNNB1 | uniprot | |
| UCP1 | uniprot | |
| WNT5B | uniprot | |
| WNT1 | uniprot | |
| SMAD3 | uniprot | |
| FZD1 | uniprot | |
| DVL1 | uniprot | |
| TCF1 | uniprot | |
| RXRG | uniprot | |
| FRZB | uniprot | |
| INS | uniprot | |
| PBEF1 | uniprot | |
| SPOCK | uniprot | |
| TRIB3 | uniprot | |
| GATA4 | uniprot | |
| NR2F1 | uniprot | |
| NRIP1 | uniprot | |
| RORA | uniprot | |
| PRLR | uniprot | |
| ADPN | uniprot | |
| CUGBP1 | uniprot | |
| HIF1A | uniprot | |
| KLF6 | uniprot | |
| KLF7 | uniprot | |
| SFRP4 | uniprot | |
| NCOR1 | uniprot | |
| NCOR2 | uniprot | |
| KLF15 | uniprot | |
| EGR2 | uniprot | |
| EBF | uniprot | |
| EPAS1 | uniprot | |
| AHR | uniprot | |
| C10orf70 | uniprot | |
| WWTR1 | uniprot | |
| GDF10 | uniprot | |
| IRS1 | uniprot | |
| IRS4 | ||
| BSCL2 | uniprot | |
| LMNA | uniprot | |
| AGPAT2 | uniprot | |
| ZMPSTE24 | uniprot | |
| LPIN1 | uniprot | |
| LPIN2 | uniprot | |
| LIPE | uniprot | |
| PCK1 | uniprot | |
| PCK2 | uniprot | |
| CEBPA | uniprot | |
| IRS2 | uniprot | |
| IRS3L | ||
| LPIN3 | uniprot | |
| E2F4 | uniprot | |
| Inhibitors of Preadipocyte to Adipocyte Transition | ||
| Transcription Factors/Modulators | ||
| Growth Factors/Hormones | ||
| Fully Differentiated Adipocyte Markers | ||
| Miscellaneous | ||
| Preadipocyte | ||
| Differentiated adipocyte | ||
| Adipocyte Secretory Products | ||
| Possible Lipodystrophy Genes | ||
| Insulin Action Genes |
| PC | ||
| 2.3.1.7 | ||
| 2.6.1.18 | ||
| ABAT | uniprot | |
| 6.3.2.11 | ||
| 3.4.13.3 | ||
| 4.1.1.11 | ||
| 4.1.1.12 | ||
| GAD2 | uniprot | |
| 2.6.1.12 | ||
| DARS | uniprot | |
| GPT | uniprot | |
| AGXT | uniprot | |
| 6.1.1.7 | ||
| 5.1.1.1 | ||
| 6.3.4.4 | ||
| ASS | uniprot | |
| 3.5.1.1 | ||
| 3.5.1.38 | ||
| 6.3.1.1 | ||
| 6.3.5.4 | ||
| 4.3.1.1 | ||
| ASL | uniprot | |
| 4.3.2.2 | ||
| 2.6.1.14 | ||
| 3.5.1.3 | ||
| 1.4.3.2 | ||
| 1.4.3.16 | ||
| 1.2.1.18 | ||
| 2.1.3.2 | ||
| GOT2 | uniprot | |
| 6.3.5.6 | ||
| DARS | uniprot | |
| 6.1.1.22 | ||
| 1.4.3.1 | ||
| 1.4.3.15 | ||
| 3.5.1.7 | ||
| 5.1.1.13 | ||
| ASPA | uniprot | |
| GAD1 | uniprot | |
| GOT1 | uniprot | |
| Glycolysis / Gluconeogenesis | ||
| Pyrimidine metabolism | ||
| Pantothenate and CoA biosynthesis | ||
| Fatty acid metabolism | ||
| Nicotinate and nicotinamide metabolism | ||
| Reductive carboxylate | chemical | |
| Citrate cycle (TCA cycle) | ||
| Reductive carboxylate cycle (CO2 fixation) | ||
| His metabolism | ||
| Nicotinate and nicotinamide metabolism | ||
| Gly, Ser and Thr metabolism | ||
| Lys biosynthesis | ||
| Urea cycle and metabolism of amino groups | ||
| Arg and Pro metabolism | ||
| beta-Ala metabolism | ||
| Selenoamino acid metabolism | ||
| Cyanoamino acid metabolism | ||
| D-Ala metabolism | ||
| Pyruvate | hmdbid:HMDB00243 | |
| O-Acetylcarnitine | hmdbid:HMDB00201 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Carnosine | hmdbid:HMDB00033 | |
| Malonate semialdehyde | hmdbid:HMDB03015 | |
| L-Alanyl-tRNA | CHEBI:17732 | |
| Protein | CHEBI:16541 | |
| D-Alanine | CHEBI:15570 | |
| L-Aspartyl-tRNA(Asp) | CHEBI:29158 | |
| N-Carbamoyl-L-aspartate | CHEBI:15859 | |
| L-Aspartate | hmdbid:HMDB00191 | |
| L-Argininosuccinate | hmdbid:HMDB00052 | |
| Adenylosuccinate | hmdbid:HMDB00536 | |
| L-Asparagine | hmdbid:HMDB00168 | |
| Citrate | hmdbid:HMDB00094 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| 2-Oxosuccinamate | CHEBI:16327 | |
| 2-Oxoglutarate | hmdbid:HMDB00208 | |
| Succinate | hmdbid:HMDB00254 | |
| Fumarate | hmdbid:HMDB00134 | |
| Malate | hmdbid:HMDB03256 | |
| L-Aspartyl- | chemical | |
| L-Asparaginyl-tRNA(Asn) | CHEBI:29265 | |
| D-Aspartate | CHEBI:29994 | |
| N-Acetyl-L-aspartate | CHEBI:16953 | |
| cycle (CO2 fixation) | ||
| tRNA(Asn) | CHEBI:29172 | |
| b-Alanine | hmdbid:HMDB00056 | |
| L-Alanine | hmdbid:HMDB00161 |
| RHOA | uniprot |
| RTKN | uniprot |
| ITGB4 | uniprot |
| FYN | uniprot |
| CLCA1 | |
| PTK2 | uniprot |
| ITGA6 | uniprot |
| LAMR1 | uniprot |
| VIM | uniprot |
| CLCA2 | |
| GRB2 | uniprot |
| DST | uniprot |
| ERBIN | uniprot |
| ERBB2 | uniprot |
| PIK3R1 | uniprot |
| PIK3R2 | uniprot |
| PIK3R3 | uniprot |
| PIK3CA | uniprot |
| PIK3CB | uniprot |
| PIK3CG | uniprot |
| PIK3CD | uniprot |
| COL17A1 | uniprot |
| SHC1 | uniprot |
| MST1R | uniprot |
| SFN | uniprot |
| LAMA1 | uniprot |
| LAMB1 | uniprot |
| LAMC1 | uniprot |
| LAMA5 | uniprot |
| LAMB2 | uniprot |
| LAMA2 | uniprot |
| LAMC1 | uniprot |
| LAMB1 | uniprot |
| LAMA5 | uniprot |
| LAMC1 | uniprot |
| LAMC1 | uniprot |
| LAMB1 | uniprot |
| LAMA2 | uniprot |
| LAMA3 | uniprot |
| LAMB3 | uniprot |
| LAMC2 | uniprot |
| PAK1 | uniprot |
| RAC1 | uniprot |
| PLEC1 | uniprot |
| CD151 | uniprot |
| IRS2 | uniprot |
| IRS1 | uniprot |
| EGFR | uniprot |
| AR | |
| TP73 | uniprot |
| ABL1 | uniprot |
| YWHAB | uniprot |
| YWHAE | uniprot |
| YWHAH | uniprot |
| YWHAQ | uniprot |
| YWHAZ | uniprot |
| YES1 | uniprot |
| DSP | uniprot |
| MET | uniprot |
| EIF4EBP1 | uniprot |
| EIF4E | uniprot |
| ITGB4BP | uniprot |
| LAMC1 | uniprot |
| LAMB2 | uniprot |
| NTN1 | uniprot |
| AKT1 | uniprot |
| CASP3 | uniprot |
| BAD | uniprot |
| PRKCA | uniprot |
| FRAP1 | uniprot |
| PRKCD | uniprot |
| MMP7 | uniprot |
| SRC | uniprot |
| RHOA | uniprot |
| SMAD2 | uniprot |
| SMAD2 | uniprot |
| SMAD3 | uniprot |
| SMAD3 | uniprot |
| ITGB4BP | uniprot |
| CDKN1A | uniprot |
| ITGA6 | uniprot |
| ITGB4 | uniprot |
| ITGB4 | uniprot |
| ITGA6 | uniprot |
| ITGB4 | uniprot |
| ITGA6 | uniprot |
| ITGB4 | uniprot |
| ITGA6 | uniprot |
| ITGB4 | uniprot |
| ITGA6 | uniprot |
| Laminin 1 | |
| Laminin 2 | |
| Laminin 11 | |
| Laminin 4 | |
| Laminin 10 | |
| CY->PM | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| Molecular Association | |
| Deacetylation | chemical |
| Autophosphorylation | chemical |
| D | |
| Translocation | |
| Plasma membrane | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Inhibition | chemical |
| Ligand | |
| Receptor | |
| Gene Symbol | |
| Molecule in the pathway | |
| Activation | chemical |
| Acetylation | chemical |
| Accession Number: NetPath_1; cellmap:1 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| NU | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Phosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Laminin 5 |
| AR | ||
| HSPA1A | uniprot | |
| STUB1 | uniprot | |
| CDC37 | uniprot | |
| CDC25B | uniprot | |
| RAS | uniprot | |
| RAF | ||
| MAP2K1 | uniprot | |
| AR | ||
| AR | ||
| AR | ||
| CDK9 | uniprot | |
| CTNNB1 | uniprot | |
| CAV1 | uniprot | |
| CREBBP | uniprot | |
| HDAC1 | uniprot | |
| SVIL | uniprot | |
| CDK7 | uniprot | |
| CCNH | uniprot | |
| GTF2H1 | uniprot | |
| CTDP1 | uniprot | |
| GTF2F1 | uniprot | |
| GTF2F2 | uniprot | |
| NCOA2 | uniprot | |
| NCOA1 | uniprot | |
| TBPIP | ||
| NR2C2 | uniprot | |
| NCOA3 | uniprot | |
| FHL2 | uniprot | |
| FLNA | uniprot | |
| FLNA | uniprot | |
| AES | uniprot | |
| BAG1 | uniprot | |
| BRCA1 | uniprot | |
| CCNE1 | uniprot | |
| CCND1 | uniprot | |
| JUN | uniprot | |
| CALR | uniprot | |
| COX5B | uniprot | |
| RUNX2 | uniprot | |
| RUNX1 | uniprot | |
| AR | ||
| SLC25A4 | uniprot | |
| ATF2 | uniprot | |
| TMF1 | uniprot | |
| NCOA4 | uniprot | |
| TGFB1I1 | ||
| RNF14 | uniprot | |
| RAN | uniprot | |
| SRISNF2L | ||
| PIAS2 | uniprot | |
| UXT | uniprot | |
| EGFR | uniprot | |
| UBE3A | uniprot | |
| ESR1 | uniprot | |
| PA2G4 | uniprot | |
| ETV5 | uniprot | |
| MMP1 | uniprot | |
| GAPDH | enzyme | uniprot |
| NR3C1 | uniprot | |
| SRC | uniprot | |
| MAPK1 | uniprot | |
| IL6ST | uniprot | |
| MYST2 | uniprot | |
| NSD1 | uniprot | |
| POU2F1 | uniprot | |
| POU2F2 | uniprot | |
| AKT1 | uniprot | |
| MDM2 | uniprot | |
| PLAGL1 | uniprot | |
| RAC3 | uniprot | |
| RB1 | uniprot | |
| RB1 | uniprot | |
| RELA | uniprot | |
| RANBP9 | uniprot | |
| NRIP1 | uniprot | |
| RNF4 | uniprot | |
| ZNF278 | uniprot | |
| PXN | uniprot | |
| SPDEF | uniprot | |
| HRMT1L2 | uniprot | |
| HRMT1L2 | uniprot | |
| PNRC1 | uniprot | |
| PIAS4 | uniprot | |
| PIAS1 | uniprot | |
| PIAS3 | uniprot | |
| STAT3 | uniprot | |
| PNRC1 | uniprot | |
| SMAD3 | uniprot | |
| SMAD4 | uniprot | |
| SRY | uniprot | |
| NR0B2 | uniprot | |
| SP1 | uniprot | |
| NCOR2 | uniprot | |
| TGIF | uniprot | |
| UBE2I | uniprot | |
| SIN3A | uniprot | |
| RCHY1 | uniprot | |
| RCHY1 | uniprot | |
| HIPK3 | uniprot | |
| PAK6 | uniprot | |
| PCAF | uniprot | |
| AKT1 | uniprot | |
| APPL | uniprot | |
| HTATIP | uniprot | |
| EP300 | uniprot | |
| SENP1 | uniprot | |
| CDC2 | uniprot | |
| MAPK1 | uniprot | |
| JUN | uniprot | |
| NR3C1 | uniprot | |
| IL6 | uniprot | |
| PTEN | uniprot | |
| ESR2 | uniprot | |
| NR0B1 | uniprot | |
| IGFI | uniprot | |
| GHBP | uniprot | |
| GHR | uniprot | |
| TP53 | uniprot | |
| CASP1 | uniprot | |
| CASP3 | uniprot | |
| CASP7 | uniprot | |
| CASP8 | uniprot | |
| HMGB2 | uniprot | |
| HMGB1 | uniprot | |
| YWHAH | uniprot | |
| NR5A1 | uniprot | |
| ESR1 | uniprot | |
| Androgen (T/DHT) | ||
| P | ||
| P | ||
| P | ||
| P | ||
| Molecular association | ||
| Proteolytic Cleavage | ||
| DeSumoylation | ||
| Phosphorylation | chemical | |
| Activation | chemical | |
| Ubiquitination | ||
| Translocation | ||
| Inhibition | chemical | |
| Enzyme complex | ||
| Androgen Independent | ||
| P | ||
| CY | ||
| NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| Gene Symbol | ||
| Molecule in the pathway | ||
| Cytoplasm | ||
| Nucleus | CHEBI:33252 | |
| D | ||
| D | ||
| D | ||
| D | ||
| (Protein-protein interaction) | ||
| Reactions through unknown mechanisms/molecules | ||
| D | ||
| Receptor | ||
| Ligand | ||
| Proteins in a complex interaction | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Sumoylation | chemical | |
| Deubiquitination | ||
| Recruitment | ||
| Control | ||
| EC | ||
| EN | ||
| Extracellular | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi appparatus | ||
| MT | ||
| Mitochondrion | ||
| PM | ||
| Plasma membrane | ||
| Androgen Independent | ||
| Accession Number: NetPath_2; cellmap:2 |
| CD79B | uniprot | |
| BLK | uniprot | |
| FYN | uniprot | |
| LYN | uniprot | |
| SYK | uniprot | |
| BLNK | uniprot | |
| MAP4K1 | uniprot | |
| CD5 | uniprot | |
| PTK2 | uniprot | |
| PTPN6 | uniprot | |
| HCLS1 | uniprot | |
| WAS | ||
| ARP2 | uniprot | |
| ARP3 | uniprot | |
| ARPC1B | uniprot | |
| ARPC2 | uniprot | |
| ARPC3 | uniprot | |
| ARPC4 | uniprot | |
| ARPC5 | uniprot | |
| HCLS1 | uniprot | |
| GRB2 | uniprot | |
| GRB2 | uniprot | |
| SOS1 | uniprot | |
| NCK1 | uniprot | |
| VAV1 | uniprot | |
| PLCG1 | uniprot | |
| CR2 | uniprot | |
| CD19 | uniprot | |
| CD81 | uniprot | |
| PLCG2 | uniprot | |
| PIK3R1 | uniprot | |
| PIK3R2 | uniprot | |
| PIK3AP1 | ||
| MAPK1 | uniprot | |
| ELK1 | uniprot | |
| BTK | uniprot | |
| CBL | uniprot | |
| SHC1 | uniprot | |
| LCK | uniprot | |
| BCAR1 | uniprot | |
| NEDD9 | uniprot | |
| PTK2B | uniprot | |
| HCK | uniprot | |
| CRKL | uniprot | |
| BANK1 | uniprot | |
| ITPR2 | uniprot | |
| PILRB | uniprot | |
| PTPN11 | uniprot | |
| CD22 | uniprot | |
| CASP9 | uniprot | |
| CASP7 | uniprot | |
| CBLB | uniprot | |
| SH3BP2 | uniprot | |
| VAV2 | uniprot | |
| PRKD1 | uniprot | |
| PTPN6 | uniprot | |
| ITK | uniprot | |
| TEC | ||
| CRK | uniprot | |
| RAPGEF1 | uniprot | |
| LCP2 | uniprot | |
| BRDG1 | uniprot | |
| DOK1 | uniprot | |
| PTPN18 | uniprot | |
| PIP5K1A | uniprot | |
| PIP5K2A | uniprot | |
| PIP5K1B | uniprot | |
| PIP5K2B | uniprot | |
| PIP5K1C | uniprot | |
| PIP5K2C | ||
| PIP5K1B | uniprot | |
| PIP5K2B | uniprot | |
| RPS6KA1 | uniprot | |
| MAPK3 | uniprot | |
| RASA1 | uniprot | |
| RPS6KA1 | uniprot | |
| PRKCD | uniprot | |
| PRKCD | uniprot | |
| CREB1 | uniprot | |
| LAT2 | uniprot | |
| PDPK1 | uniprot | |
| AKT1 | uniprot | |
| AKT1 | uniprot | |
| GSK3A | uniprot | |
| RAP2A | uniprot | |
| FOXO1A | uniprot | |
| INPP5D | ||
| DOK3 | uniprot | |
| MAPK8 | uniprot | |
| FCGR2B | uniprot | |
| HCLS1 | uniprot | |
| RPS6KB1 | uniprot | |
| RPS6 | uniprot | |
| GAB2 | uniprot | |
| JUN | uniprot | |
| ATF2 | uniprot | |
| MAPK14 | uniprot | |
| BCL6 | uniprot | |
| MAPKAPK2 | uniprot | |
| CDK2 | uniprot | |
| RB1 | uniprot | |
| CDK4 | uniprot | |
| CDK6 | uniprot | |
| CTNNB1 | uniprot | |
| CTNNB1 | uniprot | |
| GSK3B | uniprot | |
| IKBKB | enzyme | uniprot |
| CHUK | enzyme | uniprot |
| NFKBIA | uniprot | |
| RELA | uniprot | |
| REL | uniprot | |
| RELA | uniprot | |
| REL | uniprot | |
| PRKCB1 | uniprot | |
| CD72 | uniprot | |
| ATP2B4 | uniprot | |
| NFATC2 | uniprot | |
| NFATC3 | uniprot | |
| NFATC2 | uniprot | |
| NFATC3 | uniprot | |
| PPP3CA | uniprot | |
| PPP3CB | uniprot | |
| APS | uniprot | |
| GTF2I | uniprot | |
| PLEKHA1 | uniprot | |
| PLEKHA2 | uniprot | |
| DAPP1 | uniprot | |
| PLEKHA2 | uniprot | |
| PLEKHA1 | uniprot | |
| LIME1 | uniprot | |
| CSK | uniprot | |
| CARD11 | uniprot | |
| BCL10 | uniprot | |
| MAP3K7 | uniprot | |
| IKBKG | uniprot | |
| CCND2 | uniprot | |
| CCND3 | uniprot | |
| CCNE1 | uniprot | |
| CCNA2 | uniprot | |
| HNRPK | uniprot | |
| PTPRC | uniprot | |
| PPP3R1 | uniprot | |
| NFATC1 | uniprot | |
| PRKCQ | uniprot | |
| CDK7 | uniprot | |
| CD79A | uniprot | |
| DAPP1 | uniprot | |
| HDAC5 | uniprot | |
| HDAC7A | uniprot | |
| HDAC5 | uniprot | |
| HDAC7A | uniprot | |
| CYCS | uniprot | |
| CYCS | uniprot | |
| RAF1 | uniprot | |
| MAP2K1 | uniprot | |
| MAP2K2 | uniprot | |
| DUSP4 | uniprot | |
| DUSP6 | uniprot | |
| STAT3 | uniprot | |
| STAT1 | uniprot | |
| ZAP70 | uniprot | |
| BCL2L11 | uniprot | |
| MAPK4 | uniprot | |
| SLA2 | uniprot | |
| BRAG | uniprot | |
| CMTM3 | uniprot | |
| BCL2 | uniprot | |
| IGHM | uniprot | |
| PRKCB1 | uniprot | |
| RASGRP3 | uniprot | |
| BRAF | uniprot | |
| PDK2 | uniprot | |
| BAX | uniprot | |
| BAX | uniprot | |
| RASGRP3 | uniprot | |
| GAB1 | uniprot | |
| PIP5K1B | uniprot | |
| PIP5K2B | uniprot | |
| SHC1 | uniprot | |
| PRKCE | uniprot | |
| PRKCE | uniprot | |
| GTF2I | uniprot | |
| ITPR1 | uniprot | |
| PIK3AP1 | ||
| CARD11 | uniprot | |
| RAPGEF1 | uniprot | |
| CRK | uniprot | |
| BTK | uniprot | |
| BLNK | uniprot | |
| GAB1 | uniprot | |
| PTPN6 | uniprot | |
| PLCG2 | uniprot | |
| INPP5D | ||
| CHUK | enzyme | uniprot |
| IKBKB | enzyme | uniprot |
| LYN | uniprot | |
| SYK | uniprot | |
| CD79A | uniprot | |
| LYN | uniprot | |
| SYK | uniprot | |
| LAT2 | uniprot | |
| RHOA | uniprot | |
| Gene Symbol | ||
| PIK3CG | uniprot | |
| SOS2 | uniprot | |
| ARP2/3 | ||
| Complex | ||
| Molecular association | ||
| Phosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Translocation | ||
| Ubiquitination | ||
| Cytoplasm | ||
| Nucleus | CHEBI:33252 | |
| Mitochondria | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->PM | ||
| CY->PM | ||
| CY->NU | ||
| CY->PM | ||
| CY->PM | ||
| Autophosphorylation | chemical | |
| Plasma membrane | ||
| CY->PM | ||
| PM->CY | ||
| NU->CY | ||
| NU->CY | ||
| CY->MT | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| D | ||
| Receptor | ||
| Accesion Number: NetPath_12 | ||
| MA | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->NU | ||
| CY->NU | ||
| CY->PM | ||
| CY->NU | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| PM->CY | ||
| MT->CY | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| Enzyme Complex | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| D | ||
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Sumoylation | chemical | |
| Desumoylation | ||
| Deubiquitination | ||
| Activation | chemical | |
| Inhibition | chemical | |
| Recruitment | ||
| Control | ||
| PM | ||
| CY | ||
| EC | ||
| Extracellular | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi apparatus | ||
| MT | ||
| NU | ||
| Ligand | ||
| D |
| TH | ||
| DDC | uniprot | |
| DBH | uniprot | |
| PNMT | uniprot | |
| PAH | hmdbid:HMDB01867 | uniprot |
| TPH1 | uniprot | |
| DDC | uniprot | |
| ASMT | uniprot | |
| HDC | uniprot | |
| DDC | uniprot | |
| GAD1 | uniprot | |
| GAD2 | uniprot | |
| CHAT | uniprot | |
| COMT | uniprot | |
| MAOA | uniprot | |
| ACHE | uniprot | |
| MAOA | uniprot | |
| AANAT | enzyme | uniprot |
| Tyrosine | hmdbid:HMDB00158 | |
| L-DOPA | hmdbid:HMDB00181 | |
| Dopamine | hmdbid:HMDB00073 | |
| Norepinephrine | hmdbid:HMDB00216 | |
| Epinephrine | hmdbid:HMDB00068 | |
| Phenylalanine | hmdbid:HMDB00159 | |
| Tryptophan | hmdbid:HMDB00929 | |
| 5-hydroxy-tryptophan | chemical | |
| Serotonin | hmdbid:HMDB00259 | |
| Acetylserotonin | chemical | |
| Melatonin | hmdbid:HMDB01389 | |
| Histidine | hmdbid:HMDB00177 | |
| Histamine | hmdbid:HMDB00870 | |
| Glutamate | hmdbid:HMDB03339 | |
| GABA | hmdbid:HMDB00112 | |
| Choline | hmdbid:HMDB00097 | |
| Acetylcholine | hmdbid:HMDB00895 | |
| Synthesis pathways for biogenic amines (in blue) | ||
| follow solid arrows through enzymatic steps, | ||
| while degradation steps follow dashed arrows. |
| F12 | uniprot | |
| F11 | uniprot | |
| F9 | ||
| F10 | uniprot | |
| F10 | uniprot | |
| VWF | uniprot | |
| F5 | ||
| F7 | ||
| F2 | ||
| F13B | uniprot | |
| SERPINF2 | uniprot | |
| PLAU | uniprot | |
| PLAT | uniprot | |
| SERPINB2 | uniprot | |
| SERPINE1 | uniprot | |
| PLG | uniprot | |
| FGB | uniprot | |
| FGA | uniprot | |
| FGG | uniprot | |
| F8 | ||
| F8A1 | uniprot | |
| Prothrombinase Complex | ||
| Factor XIIa | ||
| Factor XIa | ||
| Factor VIIIa | ||
| Factor IXa | ||
| Factor Xa | ||
| Factor Va | ||
| Thrombin | enzyme | uniprot |
| Fibrin Monomer | ||
| Factor XIIIa | ||
| Fibrin Polymer | ||
| Factor VIIa | ||
| + | ||
| + | ||
| Intrinsic Pathway | ||
| Extrinsic Pathway | ||
| Tissue Factor | ||
| Plasmin | enzyme | |
| Fibrin | ||
| Fibrin Split Products | ||
| _ | ||
| + | ||
| Thrombolysis | ||
| _ | ||
| = | ||
| Tissue Injury |
| GNAS | uniprot | |
| GNAQ | uniprot | |
| ANXA6 | uniprot | |
| RYR2 | uniprot | |
| FKBP1A | uniprot | |
| PLN | uniprot | |
| CALR | uniprot | |
| CASQ2 | uniprot | |
| ADCY7 | uniprot | |
| RGS2 | uniprot | |
| ADCY1 | uniprot | |
| ADCY4 | uniprot | |
| RGS20 | uniprot | |
| YWHAH | uniprot | |
| PRKCB1 | uniprot | |
| YWHAQ | uniprot | |
| YWHAG | uniprot | |
| YWHAE | uniprot | |
| YWHAZ | uniprot | |
| RGS19 | uniprot | |
| SFN | uniprot | |
| PRKCH | uniprot | |
| PRKAR2A | uniprot | |
| ADCY8 | uniprot | |
| ADCY6 | uniprot | |
| PRKACB | uniprot | |
| PRKCE | uniprot | |
| PRKCZ | uniprot | |
| PRKCD | uniprot | |
| PRKD1 | uniprot | |
| ADCY9 | uniprot | |
| PRKCH | uniprot | |
| PRKCG | uniprot | |
| PRKCA | uniprot | |
| ADCY2 | uniprot | |
| PRKAR1B | uniprot | |
| PRKCQ | uniprot | |
| RGS4 | uniprot | |
| RGS17 | uniprot | |
| RGS16 | uniprot | |
| RGS14 | uniprot | |
| RGS11 | uniprot | |
| RGS10 | uniprot | |
| RGS9 | uniprot | |
| RGS7 | uniprot | |
| PRKAR2B | uniprot | |
| RGS5 | uniprot | |
| PRKACA | uniprot | |
| RGS3 | uniprot | |
| RGS1 | uniprot | |
| ADCY5 | uniprot | |
| ADCY3 | uniprot | |
| PRKAR1A | uniprot | |
| RGS18 | uniprot | |
| RGS6 | uniprot | |
| GNG2 | uniprot | |
| GNGT1 | uniprot | |
| GNB5 | uniprot | |
| GNB4 | uniprot | |
| GNB3 | uniprot | |
| GNB2 | uniprot | |
| GNB1 | uniprot | |
| GRK6 | uniprot | |
| PLCB3 | uniprot | |
| GNG4 | uniprot | |
| GRK4 | uniprot | |
| GRK5 | uniprot | |
| PKIB | uniprot | |
| CALM2 | uniprot | |
| PKIG | uniprot | |
| PKIA | uniprot | |
| GNG3 | uniprot | |
| GNG11 | uniprot | |
| GNG5 | uniprot | |
| GNG13 | uniprot | |
| GNG12 | uniprot | |
| GNG8 | uniprot | |
| GNG7 | uniprot | |
| YWHAB | uniprot | |
| PLCB3 | uniprot | |
| ARRB2 | uniprot | |
| ARRB1 | uniprot | |
| CALM1 | uniprot | |
| RYR3 | uniprot | |
| ITPR1 | uniprot | |
| ITPR2 | uniprot | |
| ITPR3 | uniprot | |
| CALM3 | uniprot | |
| GNA11 | uniprot | |
| RYR1 | uniprot | |
| CASQ1 | uniprot | |
| ATP2A2 | uniprot | |
| ATP2A3 | uniprot | |
| CAMK2A | uniprot | |
| CAMK2B | uniprot | |
| CAMK2G | uniprot | |
| CAMK2D | uniprot | |
| CAMK1 | uniprot | |
| CAMK4 | uniprot | |
| CACNB3 | uniprot | |
| CACNB1 | uniprot | |
| ATP2B3 | uniprot | |
| ATP2B2 | uniprot | |
| ATP2B1 | uniprot | |
| SLC8A3 | uniprot | |
| SLC8A1 | uniprot | |
| ATP1A4 | uniprot | |
| ATP1B1 | uniprot | |
| ATP1B2 | uniprot | |
| ATP1B3 | uniprot | |
| FXYD2 | uniprot | |
| CHRM1 | uniprot | |
| CHRM2 | uniprot | |
| CHRM3 | uniprot | |
| CHRM4 | uniprot | |
| CHRM5 | uniprot | |
| CACNA1C | uniprot | |
| CACNA1D | uniprot | |
| CACNA1E | uniprot | |
| CACNA1S | uniprot | |
| CACNA1A | uniprot | |
| CACNA1B | uniprot | |
| ADRB1 | uniprot | |
| ADRB3 | uniprot | |
| ADRB2 | uniprot | |
| ADRA1A | uniprot | |
| ADRA1B | uniprot | |
| ADRA1D | uniprot | |
| GJA1 | uniprot | |
| GJA3 | uniprot | |
| GJA4 | uniprot | |
| GJA5 | uniprot | |
| GJA6 | ||
| GJA7 | uniprot | |
| GJA8 | uniprot | |
| CX36 | ||
| GJA10 | uniprot | |
| GJA12 | uniprot | |
| GJB1 | uniprot | |
| GJB2 | uniprot | |
| GJB3 | uniprot | |
| GJB4 | uniprot | |
| GJB5 | uniprot | |
| GJB6 | uniprot | |
| KCNJ3 | uniprot | |
| KCNJ5 | uniprot | |
| KCNB1 | uniprot | |
| GNAI1 | uniprot | |
| GNAI2 | uniprot | |
| GNAI3 | uniprot | |
| GNAO1 | uniprot | |
| GNAZ | uniprot | |
| cAMP | hmdbid:HMDB00058 | |
| Ca2+ | CHEBI:29108 | |
| Na+ | CHEBI:29101 | |
| Na+ | CHEBI:29101 | |
| P | ||
| FKBP12 | uniprot | |
| P | ||
| Ca | ||
| IP3 | ||
| DAG | uniprot | |
| PIP2 | uniprot | |
| SR | ||
| GRK | ||
| Calmodulin | uniprot | |
| PKA Inhibitors | ||
| beta Arrestin | ||
| Protein Kinase A | uniprot | |
| Signaling | ||
| PKC inhibitor Protein-1 | ||
| Adenylyl Cyclases | enzyme | uniprot |
| G | ||
| Regulators of G-protein | ||
| bg | ||
| Protein Kinase C | uniprot | |
| Protein Kinase A | uniprot | |
| Na2+ | ||
| Repolarization | ||
| Cytosolic Ca | chemical | |
| 2+ | ||
| Ca | ||
| 2+ | ||
| Calreticulin-Ca | ||
| Calsequestrin C-Ca | chemical | |
| Calsequestrin S-Ca | chemical | |
| 2+ | ||
| 2+ | ||
| 2+ | ||
| 2+ | ||
| Cytosolic Ca | chemical | |
| ATP | hmdbid:HMDB00538 | |
| ADP + Pi | ||
| Phopholamban | chemical | |
| ADP + Pi | ||
| 2+ | ||
| Cytosolic Ca | chemical | |
| Acetylcholine | hmdbid:HMDB00895 | |
| Epinephrine | hmdbid:HMDB00068 | |
| Epinephrine | hmdbid:HMDB00068 | |
| IP4 | ||
| IP3 Receptors | ||
| Ca | ||
| 2+ | ||
| 2+ | ||
| Cytosol | ||
| CaM kinase | enzyme | |
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| CaM kinase | enzyme | |
| K+ | ||
| Ca | ||
| 2+ | ||
| ATP | hmdbid:HMDB00538 | |
| Dihydropyridine-Sensitive | ||
| Membrane | ||
| Depolarization | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| Na+/Ca2+ Exchanger | ||
| Na+/K+ ATPase | ||
| ATP | hmdbid:HMDB00538 | |
| Adrenergic Receptor | ||
| a | ||
| L-Type Ca2+ Channel | ||
| M1 Muscarinic Receptor | ||
| b | ||
| Adrenergic Receptor | ||
| Cyclases | uniprot | |
| Adenylyl | chemical | |
| G | ||
| b | ||
| G | ||
| g | ||
| G | ||
| bg | ||
| IP3 Receptors | ||
| Connexin | ||
| Connexin | ||
| Gap Junctions (Connexins) | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| b | ||
| arrestin/GRK | ||
| b | ||
| arrestin/GRK | ||
| G alpha i/o/z | ||
| K+ | ||
| K+ | ||
| G | ||
| bg | ||
| G alpha i/o/z |
| CDK4 | uniprot | |
| CDK6 | uniprot | |
| CCND1 | uniprot | |
| CCND2 | uniprot | |
| CCND3 | uniprot | |
| CyclinD | uniprot | |
| Cdk | uniprot | |
| CDKN1A | uniprot | |
| CDKN1B | uniprot | |
| CDK7 | uniprot | |
| CCNH | uniprot | |
| CyclinD | uniprot | |
| Cdk | uniprot | |
| RB1 | uniprot | |
| E2f | uniprot | |
| E2F1 | uniprot | |
| E2F2 | uniprot | |
| E2F3 | uniprot | |
| RBL1 | uniprot | |
| RB1 | uniprot | |
| E2F4 | uniprot | |
| E2F5 | uniprot | |
| E2F6 | uniprot | |
| RB1 | uniprot | |
| E2f | uniprot | |
| TFDP1 | uniprot | |
| TFDP1 | uniprot | |
| TFDP2 | uniprot | |
| CDK2 | uniprot | |
| CCNE1 | uniprot | |
| CCNE2 | uniprot | |
| POLE2 | uniprot | |
| POLE | uniprot | |
| CDC25A | uniprot | |
| WEE1 | uniprot | |
| MYT1 | uniprot | |
| CCNE1 | uniprot | |
| CCNE1 | uniprot | |
| CDK4 | uniprot | |
| CDK6 | uniprot | |
| CDK7 | uniprot | |
| CDC45L | uniprot | |
| RPA2 | uniprot | |
| RPA3 | uniprot | |
| RPA1 | uniprot | |
| MCM2 | uniprot | |
| MCM3 | uniprot | |
| MCM4 | uniprot | |
| MCM5 | uniprot | |
| MCM6 | uniprot | |
| MCM7 | uniprot | |
| ORC1L | uniprot | |
| ORC2L | uniprot | |
| ORC3L | uniprot | |
| ORC4L | uniprot | |
| ORC5L | uniprot | |
| ORC6L | uniprot | |
| PRIM1 | uniprot | |
| PRIM2A | uniprot | |
| POLA2 | uniprot | |
| PCNA | uniprot | |
| TP53 | uniprot | |
| GADD45A | uniprot | |
| MDM2 | uniprot | |
| CDKN2C | uniprot | |
| CDKN2B | uniprot | |
| CDKN2D | uniprot | |
| CDKN2A | uniprot | |
| CCNA1 | uniprot | |
| CCNB1 | uniprot | |
| ATM | uniprot | |
| TP53 | uniprot | |
| CDKN1C | uniprot | |
| CCNG2 | uniprot | |
| MYC | uniprot | |
| CREB1 | uniprot | |
| CREBL1 | uniprot | |
| CREB3L1 | ||
| CREB3 | uniprot | |
| CREB3L4 | ||
| CREB3L3 | ||
| MNAT1 | uniprot | |
| CDC2A | uniprot | |
| CDK | ||
| CDC2A | uniprot | |
| CDK | ||
| G1 Cyclin | ||
| Cyclin Ds | chemical | |
| p | ||
| p | ||
| p | ||
| p | ||
| E2f | uniprot | |
| Rb | ||
| dp1 | uniprot | |
| Dependent Kinases | ||
| TTTCC/GCGC | ||
| Cell cycle DNA replication genes | ||
| G1 Phase | ||
| G1/S transition Phase | ||
| Dependent Kinases | ||
| Cyclin Es | chemical | |
| G1/S transition Cyclin | ||
| p | ||
| inactive | ||
| phosphorylation of proteins | ||
| involved in G1/S transition | ||
| DNA polymerases | uniprot | |
| DNA replication | ||
| origen recognition | ||
| complex | ||
| p | ||
| G1/S Cell Cycle | ||
| Checkpoint | ||
| G2 Phase-M phase | ||
| u | ||
| u | ||
| u | ||
| Degredation | ||
| p | ||
| e | ||
| cak | uniprot | |
| b | ||
| b | ||
| e |
| ORC6L | uniprot | |
| ORC3L | uniprot | |
| ORC5L | uniprot | |
| ORC4L | uniprot | |
| ORC1L | uniprot | |
| MCM7 | uniprot | |
| MCM6 | uniprot | |
| MCM5 | uniprot | |
| MCM4 | uniprot | |
| MCM3 | uniprot | |
| BUB1B | uniprot | |
| ATM | uniprot | |
| ABL1 | uniprot | |
| ATR | uniprot | |
| MAD2L2 | uniprot | |
| BUB1 | uniprot | |
| BUB3 | uniprot | |
| EP300 | uniprot | |
| WEE1 | uniprot | |
| PTTG1 | uniprot | |
| PTTG2 | ||
| PTTG3 | ||
| RB1 | uniprot | |
| RB1 | uniprot | |
| CDC25B | uniprot | |
| CDC25C | uniprot | |
| CDK2 | uniprot | |
| CDK2 | uniprot | |
| CDK4 | uniprot | |
| CDK6 | uniprot | |
| CCNH | uniprot | |
| MAD1L1 | uniprot | |
| GSK3B | uniprot | |
| ORC2L | uniprot | |
| CCND3 | uniprot | |
| CCND2 | uniprot | |
| CDKN2A | uniprot | |
| CDKN1A | uniprot | |
| CCNE1 | uniprot | |
| CCNA1 | uniprot | |
| CCNA2 | uniprot | |
| PCNA | uniprot | |
| YWHAG | uniprot | |
| GADD45A | uniprot | |
| CDC25A | uniprot | |
| HDAC1 | uniprot | |
| HDAC2 | uniprot | |
| HDAC3 | uniprot | |
| HDAC5 | uniprot | |
| HDAC6 | uniprot | |
| HDAC7A | uniprot | |
| HDAC8 | uniprot | |
| MCM2 | uniprot | |
| CDK2 | uniprot | |
| TP53 | uniprot | |
| PRKDC | uniprot | |
| CHEK1 | uniprot | |
| CHEK2 | uniprot | |
| MPEG1 | ||
| MAD2L1 | uniprot | |
| CDC2 | uniprot | |
| CCNA2 | uniprot | |
| CCNA1 | uniprot | |
| CCNB1 | uniprot | |
| CCNB2 | uniprot | |
| CCNB3 | uniprot | |
| CDC2 | uniprot | |
| RB1 | uniprot | |
| TFDP1 | uniprot | |
| RBL1 | uniprot | |
| CDC7 | uniprot | |
| ASK | uniprot | |
| CDC45L | uniprot | |
| CDC6 | uniprot | |
| CDKN1B | uniprot | |
| PKMYT1 | uniprot | |
| SKP2 | uniprot | |
| SKP2 | uniprot | |
| CDC14A | uniprot | |
| CDC14B | uniprot | |
| CDH1 | uniprot | |
| TBC1D8 | uniprot | |
| MEN | ||
| ESPL1 | uniprot | |
| SMC1L1 | uniprot | |
| MDM2 | uniprot | |
| ARF | uniprot | |
| E2F1 | uniprot | |
| E2F2 | uniprot | |
| E2F3 | uniprot | |
| E2F5 | uniprot | |
| E2F4 | uniprot | |
| RBL1 | uniprot | |
| E2F6 | uniprot | |
| UBE2F | ||
| 14-3-3 | ||
| PLK1 | uniprot | |
| SMAD3 | uniprot | |
| TGFB1 | uniprot | |
| SMAD4 | uniprot | |
| HDAC4 | uniprot | |
| CCNE2 | uniprot | |
| CDC20 | uniprot | |
| MAPK | enzyme | uniprot |
| signaling | ||
| pathway | ||
| Growth Factor | ||
| Growth Factor | ||
| withdrawal | ||
| R-point | ||
| (Start) | ||
| +p | ||
| e | ||
| e | ||
| p16,15,18,19 | ||
| p27,57 | ||
| p21 | uniprot | |
| Histone Deacetylases | uniprot | |
| +u | ||
| +u | ||
| +u | ||
| +p | ||
| e | ||
| e | ||
| e | ||
| Apoptosis | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| HDAC | ||
| E2F | ||
| DNA | CHEBI:16991 | |
| SCF | uniprot | |
| ORC | ||
| MCM | uniprot | |
| +p | ||
| DNA | CHEBI:16991 | |
| DNA biosynthesis | ||
| S-phase proteins | ||
| +p | ||
| SCF | uniprot | |
| -p | ||
| APC/C | ||
| -p | ||
| +p | ||
| +p | ||
| APC/C | ||
| +u | ||
| DNA damage checkpoint | ||
| Securin | uniprot | |
| Separin | hmdbid:HMDB05005 | uniprot |
| Condensin | ||
| Transcription Factor E2F | ||
| Ubiquitin | uniprot | |
| mediated | ||
| proteolysis | chemical | |
| ORC (Origin | ||
| Recognition Complex) | ||
| MCM (Mini-Chromosome | ||
| Maintenance) complex | ||
| G1 | ||
| M | ||
| G2 | ||
| S | ||
| +p | ||
| +u |
| FDPS | uniprot | |
| IDI1 | uniprot | |
| HMGCS1 | uniprot | |
| HMGCR | uniprot | |
| MVK | uniprot | |
| MVD | uniprot | |
| FDPS | uniprot | |
| FDFT1 | uniprot | |
| DHCR7 | uniprot | |
| SC5DL | uniprot | |
| LSS | uniprot | |
| SQLE | uniprot | |
| PMVK | uniprot | |
| NSDHL | uniprot | |
| CYP51A1 | uniprot | |
| SC4MOL | uniprot | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| HMG-CoA | hmdbid:HMDB01375 | |
| Geranyl-PP | hmdbid:HMDB01285 | |
| Squalene | hmdbid:HMDB00256 | |
| Squalene-2,3-Epoxide | hmdbid:HMDB01188 | |
| Lanosterol | hmdbid:HMDB01251 | |
| Lathosterol | hmdbid:HMDB01170 | |
| 7-dehydro Cholesterol | hmdbid:HMDB00032 | |
| Cholesterol | hmdbid:HMDB00067 | |
| Mevalonate | hmdbid:HMDB00227 | |
| Mevalonate-5-P | chemical | |
| Mevalonate-5-PP | chemical | |
| Delta-Isopentenyl-5-PP | chemical | |
| trans-trans-farnesyl-pp | ||
| DiMethylally-PP | chemical | |
| Fatty Acid Degradation |
| MYF6 | uniprot |
| KLF9 | uniprot |
| HERPUD1 | uniprot |
| SF3A3 | uniprot |
| CBX3 | uniprot |
| AZIN1 | uniprot |
| PSMA4 | uniprot |
| ZFR | |
| SUMO1 | uniprot |
| HIST1H2BN | uniprot |
| PURA | uniprot |
| CRY2 | uniprot |
| PER1 | uniprot |
| PER2 | uniprot |
| CRY1 | uniprot |
| PPP1R3C | |
| CEBPB | uniprot |
| PPP2CB | uniprot |
| NCOA4 | uniprot |
| ETV6 | uniprot |
| CAST | uniprot |
| HLA-DMA | uniprot |
| HSPA8 | uniprot |
| DNAJA1 | uniprot |
| UCP3 | uniprot |
| GSTM3 | uniprot |
| UGP2 | uniprot |
| CLDN5 | uniprot |
| PIGF | uniprot |
| TUBB3 | uniprot |
| GFRA1 | uniprot |
| MAP3K7IP2 | uniprot |
| SUMO3 | uniprot |
| GSTP1 | uniprot |
| NCKAP1 | uniprot |
| VAPA | uniprot |
| GENX-3414 | uniprot |
| DAZAP2 | uniprot |
| IDI1 | uniprot |
| TOB1 | uniprot |
| RBPMS | uniprot |
| G0S2 | uniprot |
| ARNTL | uniprot |
| NR1D2 | uniprot |
| CLOCK | uniprot |
| BTG1 | uniprot |
| EIF4G2 | uniprot |
| QKI | uniprot |
| Per1 | uniprot |
| Per2 | uniprot |
| E-Box | |
| LRE | |
| LRE | |
| Cry1 | uniprot |
| Cry2 | uniprot |
| Per | |
| Cry | |
| Metabolism | |
| Chaperone | |
| Protein Modification | |
| Transcription | |
| Cell Cycle | |
| DNA/RNA Binding | |
| Other | |
| Structural/Cytoskeleton | |
| Signaling | |
| mHrts | |
| mHrts | |
| mHrts | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrp mSCNp | |
| mHrts | |
| mSCNp | |
| mHrts | |
| mLvrs | |
| mHrts | |
| mHrts | |
| mHrts | |
| mLvrs | |
| mLvrs | |
| mLvrp | |
| mLvrp | |
| mLvrp | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrs,p SCNp | |
| mHrts | |
| mLvrs | |
| mSCNp | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrp mSCNp | |
| mLvrs | |
| mLvrs | |
| mHrts | |
| mLvrp | |
| mSCNp | |
| mHrts | |
| mHrts | |
| mLvrs,p | chemical |
| mLvrp | |
| mLvrp | |
| mHrts Lvrsp | |
| mHrts mLvrs | |
| mLvrs,p | chemical |
| mHrts mLvrs, mSCNp | |
| Nucleus | CHEBI:33252 |
| mHrts mLvrs,p mSCN | |
| mHrts mLvrs,p | |
| mHrts mLvrs | |
| mHrts mLvrp | |
| mHrts mLvrs,p mSCNp | |
| E-Box |
| C1QA | uniprot |
| C1QB | uniprot |
| C1QG | uniprot |
| C1R | uniprot |
| C1S | uniprot |
| DAF | uniprot |
| MASP1 | uniprot |
| C2 | |
| C3 | |
| C5 | |
| C6 | |
| C7 | |
| C8A | uniprot |
| C8B | uniprot |
| C9 | |
| C4A | uniprot |
| C4B | uniprot |
| antigen/antibody | |
| complex | |
| C1 complex | |
| aggregated IgG, | |
| IgM-antigen complex, | |
| polyanions, RNA, DNA | |
| lipopolysacharides | |
| Membrane | |
| attack complex | |
| Ions | CHEBI:24870 |
| H O | |
| 2 | |
| Cytoplasm | |
| Plasma | |
| Membrane | |
| Prevents Complement Attack | |
| Proteolytic Cleavage | |
| Complex | |
| Formation |
| C1QB | uniprot | |
| C1QA | uniprot | |
| C1QG | uniprot | |
| C1R | uniprot | |
| C1S | uniprot | |
| Daf2 | uniprot | |
| Daf1 | uniprot | |
| C2 | ||
| C4 | ||
| C3 | ||
| Hc | ||
| C6 | ||
| C9 | ||
| MASP1 | uniprot | |
| CD59A | ||
| MCP | uniprot | |
| CRRY | ||
| CFI | enzyme | uniprot |
| MASP2 | enzyme | uniprot |
| MBL1 | ||
| SERPING1 | uniprot | |
| C4BP | uniprot | |
| C3AR1 | uniprot | |
| C5R1 | uniprot | |
| CR2 | uniprot | |
| CR1 | uniprot | |
| H2-BF | ||
| ADN | ||
| CFH | uniprot | |
| F3 | ||
| F7 | ||
| F9 | ||
| F8 | ||
| 109821 | ||
| VWF | uniprot | |
| F10 | uniprot | |
| F5 | ||
| F2 | ||
| FGB | uniprot | |
| SERPIND1 | uniprot | |
| CPB2 | uniprot | |
| TFPI | uniprot | |
| F13B | uniprot | |
| F2R | uniprot | |
| SERPINC1 | uniprot | |
| SERPINA5 | uniprot | |
| A2M | uniprot | |
| SERPINA1 | uniprot | |
| PROC | uniprot | |
| PROS1 | uniprot | |
| PLAT | uniprot | |
| PLAU | uniprot | |
| THBD | uniprot | |
| SERPINE1 | uniprot | |
| PLAUR | uniprot | |
| PLG | uniprot | |
| F12 | uniprot | |
| KLKB1 | uniprot | |
| KNG1 | uniprot | |
| SERPINF2 | uniprot | |
| BDKRB1 | uniprot | |
| C7 | ||
| C8G | uniprot | |
| membrane attack complex | ||
| Cell lysis | ||
| C3 | ||
| Convertase | ||
| C3b | ||
| Antibody/antigen | ||
| complex | ||
| C4b/2a | ||
| Muscle contraction, | ||
| Chemotaxis, | ||
| Phagocyte recruitment | ||
| Inflammation, etc. | ||
| C5a | ||
| C3a | ||
| C4a | uniprot | |
| C3b/4b, C3b, C3d | ||
| Mediators | ||
| Classical Pathway | ||
| C3b/Bb | ||
| insulin, etc. | ||
| Zymosan | ||
| Alternative Pathway | ||
| Complement Cascade | ||
| Lectin Pathway | ||
| Thrombin | enzyme | uniprot |
| Clot | ||
| fibrin degredation | ||
| Vascular injury | ||
| products | ||
| Fibrin | ||
| monomer | ||
| Cross-linked | ||
| fibrin polymer | ||
| Platelet, monocyte, | ||
| lymphocyte, | ||
| endothelial cells, | ||
| smooth muscle cells | ||
| activation, etc. | ||
| Coagulation Cascade | ||
| Extrinsic pathway | ||
| Degredation | ||
| Cell adhesion, | ||
| migration, | ||
| proliferation, etc. | ||
| Cell adhesion, | ||
| migration, | ||
| proliferation, etc. | ||
| Bradykinin | uniprot | |
| Collagen, | ||
| basement membrane, | ||
| activated platelets, etc. | ||
| Fibrinolytic system | ||
| Kinin kallikrein system |
| CXCL2 | uniprot |
| TNF | uniprot |
| IL1B | uniprot |
| IL1A | uniprot |
| IL6 | uniprot |
| TNF | uniprot |
| IL1B | uniprot |
| IL1A | uniprot |
| TNF | uniprot |
| TGFB1 | uniprot |
| TNF | uniprot |
| IL1A | uniprot |
| IL1B | uniprot |
| TNF | uniprot |
| IL1A | uniprot |
| IL1B | uniprot |
| IL6 | uniprot |
| IL11 | uniprot |
| IL12B | uniprot |
| CSF1 | uniprot |
| CSF2 | uniprot |
| CSF3 | uniprot |
| CD4 | uniprot |
| IL1A | uniprot |
| IL1B | uniprot |
| IL6 | uniprot |
| IL10 | uniprot |
| CXCL1 | uniprot |
| IL12 | |
| IL15 | uniprot |
| IFN1@ | |
| IFNB1 | uniprot |
| TNF | uniprot |
| IL3 | uniprot |
| IL6 | uniprot |
| IL7 | uniprot |
| CSF2 | uniprot |
| IL3 | uniprot |
| IL4 | uniprot |
| IL10 | uniprot |
| IL13 | uniprot |
| IFNG | uniprot |
| TNF | uniprot |
| IL2 | uniprot |
| IL12B | uniprot |
| IL15 | uniprot |
| IL2 | uniprot |
| IFNG | uniprot |
| IL15 | uniprot |
| IL3 | uniprot |
| IL4 | uniprot |
| IL10 | uniprot |
| IL4 | uniprot |
| IL10 | uniprot |
| IL4 | uniprot |
| IL6 | uniprot |
| TGFB1 | uniprot |
| IL2 | uniprot |
| IL4 | uniprot |
| IL5 | uniprot |
| IL13 | uniprot |
| IFNG | uniprot |
| IL3 | uniprot |
| IL5 | uniprot |
| TGFB1 | uniprot |
| IL2 | uniprot |
| IL2 | uniprot |
| IL2 | uniprot |
| IFN1@ | |
| PDGFA | uniprot |
| Macrophage | |
| Neutrophil | |
| T-helper | |
| Hypothalamus | |
| Fibroblasts | |
| Endothelial Cells | |
| Inflammatory Response | |
| Hematopoietic Stem Cell | |
| Hematopoiesis | |
| TCR | |
| T-helper | |
| NK cell | |
| Lymphocyte Activated | |
| Mast Cell | |
| B Cell | |
| B Cell | |
| B Cell | |
| B Cell | |
| Plasma Cell | |
| Antibodies | |
| Killer Cells (LAK) | |
| Eos | |
| Eos | |
| Eos | |
| Th | |
| Th | |
| Th | |
| Tc | |
| Tc | |
| Tc | |
| clonal expansion of T cells | |
| (fever) | |
| MHC II |
| NOTCH1 | uniprot | |
| NOTCH2 | uniprot | |
| NOTCH3 | uniprot | |
| NOTCH4 | uniprot | |
| DLL1 | uniprot | |
| DLL4 | uniprot | |
| JAG1 | uniprot | |
| JAG2 | uniprot | |
| PSEN1 | uniprot | |
| PSEN2 | uniprot | |
| APH1A | uniprot | |
| APH1B | uniprot | |
| PSENEN | uniprot | |
| NCSTN | uniprot | |
| ADAM10 | uniprot | |
| DLL1 | uniprot | |
| DLL1 | uniprot | |
| ADAM17 | uniprot | |
| NOTCH1 | uniprot | |
| NOTCH1 | uniprot | |
| NOTCH2 | uniprot | |
| NOTCH4 | uniprot | |
| GSK3B | uniprot | |
| NOTCH2 | uniprot | |
| GSK3B | uniprot | |
| NUMB | uniprot | |
| ITCH | uniprot | |
| APP | uniprot | |
| NUMBL | uniprot | |
| PIK3R1 | uniprot | |
| PIK3R2 | uniprot | |
| AKT1 | uniprot | |
| FURIN | uniprot | |
| CNTN1 | uniprot | |
| NOV | uniprot | |
| DTX1 | uniprot | |
| ASCL1 | uniprot | |
| EP300 | uniprot | |
| TP53 | uniprot | |
| LFNG | uniprot | |
| MFNG | uniprot | |
| POFUT1 | uniprot | |
| SKP1A | uniprot | |
| FBXW7 | uniprot | |
| HEY1 | uniprot | |
| MAML2 | uniprot | |
| MAML3 | uniprot | |
| MAML1 | uniprot | |
| SNW1 | uniprot | |
| NCOR2 | uniprot | |
| NCOR1 | uniprot | |
| HDAC1 | uniprot | |
| CIR | hmdbid:HMDB00904 | uniprot |
| SAP30 | uniprot | |
| HDAC2 | uniprot | |
| SIN3A | uniprot | |
| HES1 | uniprot | |
| STAT3 | uniprot | |
| JAK2 | uniprot | |
| NCOR1 | uniprot | |
| NCOR2 | uniprot | |
| RELA | uniprot | |
| NFKBIA | uniprot | |
| HEY2 | uniprot | |
| TLE1 | uniprot | |
| RELA | uniprot | |
| SMAD3 | uniprot | |
| SMAD4 | uniprot | |
| YY1 | uniprot | |
| CDK2 | uniprot | |
| LEF1 | uniprot | |
| MEF2C | uniprot | |
| SKP1A | uniprot | |
| CUL1 | uniprot | |
| SKP2 | uniprot | |
| RBX1 | uniprot | |
| TCF3 | uniprot | |
| MAPK3 | uniprot | |
| MAPK1 | uniprot | |
| WDR12 | uniprot | |
| PCAF | uniprot | |
| FHL1 | uniprot | |
| RING1 | uniprot | |
| HIVEP3 | ||
| SPEN | uniprot | |
| EP300 | uniprot | |
| SMAD1 | uniprot | |
| HES6 | uniprot | |
| GATA1 | uniprot | |
| MAGEA1 | uniprot | |
| CNTFR | uniprot | |
| CNTF | uniprot | |
| HES5 | ||
| LCK | uniprot | |
| STAT3 | uniprot | |
| JUN | uniprot | |
| RBPSUH | uniprot | |
| NOTCH3 | uniprot | |
| DTX1 | uniprot | |
| SKP2 | uniprot | |
| EGF | uniprot | |
| EGFR | uniprot | |
| JAG1 | uniprot | |
| JAG1 | uniprot | |
| JAG2 | uniprot | |
| NOTCH1 | uniprot | |
| DLL4 | uniprot | |
| JAG2 | uniprot | |
| NOTCH3 | uniprot | |
| NOTCH1 | uniprot | |
| NOTCH1 | uniprot | |
| NOTCH2 | uniprot | |
| Molecular association | ||
| Phosphorylation | chemical | |
| Proteolytic Cleavage | ||
| Ubiquitination | ||
| Translocation | ||
| Gamma secretase complex | ||
| Intracellular Domain | ||
| -- ICD | ||
| ICD | ||
| ICD | ||
| ICD | ||
| ICD | ||
| ICD | ||
| Glycosylation | ||
| PM | ||
| GO->PM | ||
| CY->NU | ||
| NU->CY | ||
| PM->NU | ||
| PM->NU | ||
| PM->NU | ||
| NU->CY | ||
| NU->CY | ||
| D | ||
| D | ||
| D | ||
| GO->PM | ||
| PM->CY | ||
| PM->NU | ||
| ICD | ||
| (Protein-protein interaction) | ||
| Activation | chemical | |
| Inhibition | chemical | |
| D | ||
| Reactioin through unknown mechanisms/molecules | ||
| Receptor | ||
| Ligand | ||
| Gene Symbol | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| CY | ||
| Plasma membrane | ||
| Cytoplasm | ||
| GO | ||
| Golgi apparatus | ||
| Nucleus | CHEBI:33252 | |
| NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| Accession Number: NetPath_3; cellmap:3 | ||
| Enzyme complex | ||
| D | ||
| D | ||
| CY->NU | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Sumoylation | chemical | |
| Desumoylation | ||
| Deubiquitination | ||
| Recruitment | ||
| Control | ||
| EC | ||
| Extracellular | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| MT | ||
| Mitochondrion |
| RPA2 | uniprot | |
| RPA3 | uniprot | |
| RPA4 | uniprot | |
| POLA | uniprot | |
| PRIM1 | uniprot | |
| PRIM2A | uniprot | |
| POLE2 | uniprot | |
| POLE | uniprot | |
| ORC3L | uniprot | |
| ORC2L | uniprot | |
| ORC5L | uniprot | |
| ORC4L | uniprot | |
| ORC1L | uniprot | |
| ORC6L | uniprot | |
| GMNN | uniprot | |
| CDT1 | uniprot | |
| UBA52 | uniprot | |
| MCM6 | uniprot | |
| MCM5 | uniprot | |
| MCM4 | uniprot | |
| MCM3 | uniprot | |
| MCM2 | uniprot | |
| MCM7 | uniprot | |
| MCM10 | uniprot | |
| CDK2 | uniprot | |
| POLA2 | uniprot | |
| RFC5 | uniprot | |
| RFC4 | uniprot | |
| RFC3 | uniprot | |
| RFC2 | uniprot | |
| RFC1 | uniprot | |
| PCNA | uniprot | |
| ASK | uniprot | |
| CDC7 | uniprot | |
| RPA1 | uniprot | |
| CDC45L | uniprot | |
| POLD2 | uniprot | |
| POLD3 | uniprot | |
| POLD4 | uniprot | |
| POLD1 | uniprot | |
| CDC6 | uniprot | |
| UBC | uniprot | |
| Origin | ||
| Orc3 | uniprot | |
| Orc2 | uniprot | |
| Orc5 | uniprot | |
| Orc2 | uniprot | |
| Orc3 | uniprot | |
| Orc5 | uniprot | |
| Orc4 | uniprot | |
| Orc1 | uniprot | |
| Orc3 | uniprot | |
| Orc5 | uniprot | |
| Orc4 | uniprot | |
| Orc2 | uniprot | |
| Cdc6 | uniprot | |
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Cdt1 | uniprot | |
| Geminin | uniprot | |
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Mcm10 | uniprot | |
| Cdt1 | uniprot | |
| Phosphorylation of Mcm 2-7 complex | ||
| DNA polymerase alpha: primase: origin complex | ||
| DNA polymerase alpha: primase: origin complex | ||
| CTP | hmdbid:HMDB00082 | uniprot |
| GTP | hmdbid:HMDB01273 | |
| UTP | hmdbid:HMDB00285 | |
| ATP | hmdbid:HMDB00538 | |
| RNA Primer | ||
| dCTP | hmdbid:HMDB00998 | |
| dGTP | hmdbid:HMDB01440 | |
| dUTP | hmdbid:HMDB01191 | |
| dATP | hmdbid:HMDB01532 | |
| Phosphorylated Orc1 | ||
| Ubiquitin | uniprot | |
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| Phosphorylated Cdc6 | ||
| Ubiquitinated Orc1 | ||
| Ubiquitinated Cdc6 | ||
| Degraded by proteasome in cytosol | ||
| Degraded by proteasome in cytosol | ||
| RNA primer-DNA primer | ||
| RNA primer-DNA primer | ||
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| p49 | uniprot | |
| p58 | uniprot | |
| p70 | uniprot | |
| p180 | uniprot | |
| RFC36 | uniprot | |
| RFC37 | uniprot | |
| RFC38 | uniprot | |
| RFC40 | uniprot | |
| RFC140 | uniprot | |
| Mcm 4,6,7 trimer forms and associates | ||
| Ubiquitin | uniprot | |
| with the replication fork | ||
| Orc2 | uniprot | |
| Orc3 | uniprot | |
| RFC Heteropentamer:RNA primer-DNA primer | ||
| ATP | hmdbid:HMDB00538 | |
| PCNA homotrimer | ||
| RFC Heteropentamer:RNA primer-DNA primer: | ||
| RNA primer-DNA primer:origin duplex:PCNA | ||
| Primase | ||
| DNA Polymerase | uniprot | |
| a | ||
| Pre-replicative complex | ||
| 2. Activation of the pre-replicative complex | ||
| 3. DNA replication initiation | ||
| Pre-replicative complex | ||
| 1. Assembly of the pre-replicative complex | ||
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| Orc Complex | ||
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| 4. Switching of origins to post-replicative state | ||
| 5. Leading/lagging strand synthesis | ||
| Orc complex | ||
| Processive complex | ||
| Orc complex | ||
| Orc complex | ||
| Orc complex | ||
| Mcm5 | uniprot | |
| Mcm5 | uniprot |
| EGF | uniprot |
| RAF1 | uniprot |
| HRAS | uniprot |
| NRAS | uniprot |
| KRAS2 | uniprot |
| SHOC2 | uniprot |
| PIK3R1 | uniprot |
| MAP3K2 | uniprot |
| GRB14 | uniprot |
| GRB2 | uniprot |
| GRB10 | uniprot |
| MAP3K3 | uniprot |
| SOS1 | uniprot |
| GRB7 | uniprot |
| PIK3R2 | uniprot |
| SHC1 | uniprot |
| PIK3R3 | uniprot |
| PIK3CA | uniprot |
| PIK3CB | uniprot |
| PIK3CD | uniprot |
| PIK3CG | uniprot |
| GAB1 | uniprot |
| GAB2 | uniprot |
| JAK1 | uniprot |
| STAT1 | uniprot |
| JAK2 | uniprot |
| STAT3 | uniprot |
| STAT5A | uniprot |
| STAT2 | uniprot |
| STAT5B | uniprot |
| MAP2K1 | uniprot |
| PRKCA | uniprot |
| MAP3K1 | uniprot |
| PRKCZ | uniprot |
| PRKCM | uniprot |
| PRKCI | uniprot |
| PRKCB1 | uniprot |
| PRKCG | uniprot |
| MAP2K2 | uniprot |
| MAP2K3 | uniprot |
| MAP2K5 | uniprot |
| MAP3K4 | uniprot |
| VAV1 | uniprot |
| VAV3 | uniprot |
| VAV2 | uniprot |
| MAPK7 | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| ELK4 | uniprot |
| ELK1 | uniprot |
| MAPK8 | uniprot |
| MAP2K7 | uniprot |
| PTPRR | uniprot |
| GJA1 | uniprot |
| YWHAB | uniprot |
| WNK1 | uniprot |
| EGFR | uniprot |
| KRT7 | uniprot |
| KRT8 | uniprot |
| KRT17 | uniprot |
| KRT18 | uniprot |
| HIST3H3 | uniprot |
| SNRPD2 | uniprot |
| EPPK1 | uniprot |
| PLEC1 | uniprot |
| PTPN12 | uniprot |
| STAT3 | uniprot |
| PLSCR1 | uniprot |
| ERRFI1 | uniprot |
| DOK2 | uniprot |
| PITPNA | uniprot |
| CBLC | uniprot |
| CBLB | uniprot |
| PLD2 | uniprot |
| PLD1 | uniprot |
| PRKCA | uniprot |
| EPS15 | uniprot |
| EPS8 | uniprot |
| HD | |
| PIK3C2B | uniprot |
| SH3BGRL | uniprot |
| CSK | uniprot |
| REPS2 | uniprot |
| RALBP1 | uniprot |
| RALB | uniprot |
| REPS1 | uniprot |
| TNK2 | uniprot |
| ABI1 | uniprot |
| SOS2 | uniprot |
| DNM1 | uniprot |
| SH3GL3 | uniprot |
| CDC42 | uniprot |
| SPRY2 | uniprot |
| JUND | uniprot |
| FOS | uniprot |
| CEBPA | uniprot |
| MYC | uniprot |
| CEBPB | uniprot |
| PEBP1 | uniprot |
| KLF11 | uniprot |
| SIN3A | uniprot |
| TGIF | uniprot |
| HDAC1 | uniprot |
| SH3KBP1 | uniprot |
| SH3GL2 | uniprot |
| JUN | uniprot |
| SP1 | uniprot |
| AKT1 | uniprot |
| PTPN5 | uniprot |
| SNCA | uniprot |
| RPS6KA1 | uniprot |
| RPS6KA3 | uniprot |
| RPS6KA2 | uniprot |
| AP2A1 | uniprot |
| WASL | uniprot |
| CEACAM1 | uniprot |
| EEF1A1 | uniprot |
| APPL | uniprot |
| DIP13B | uniprot |
| MTA2 | uniprot |
| EPS15L1 | uniprot |
| EPN1 | uniprot |
| HIP1 | uniprot |
| RFXANK | uniprot |
| MAPK14 | uniprot |
| TNIP1 | uniprot |
| EGFR | uniprot |
| EGFR | uniprot |
| RBBP7 | uniprot |
| DDEF1 | uniprot |
| STXBP1 | uniprot |
| CTNND1 | uniprot |
| PKN2 | uniprot |
| PAK1 | uniprot |
| SH2D3C | uniprot |
| BCAR1 | uniprot |
| CASP9 | uniprot |
| RPS6KA5 | uniprot |
| SMAD2 | uniprot |
| SMAD3 | uniprot |
| SMAD2 | uniprot |
| SMAD3 | uniprot |
| ATF1 | uniprot |
| CREB1 | uniprot |
| FOXO1A | uniprot |
| PXN | uniprot |
| ELF3 | uniprot |
| HAT1 | uniprot |
| CAMK2A | uniprot |
| ITCH | uniprot |
| ARAF | uniprot |
| MCF2 | uniprot |
| ELF3 | uniprot |
| RPS6KA3 | uniprot |
| MAP3K2 | uniprot |
| FOXO1A | uniprot |
| EPS15 | uniprot |
| EEF1A1 | uniprot |
| STAT1 | uniprot |
| STAT3 | uniprot |
| STAT2 | uniprot |
| STAT5A | uniprot |
| ZNF259 | uniprot |
| PLCG1 | uniprot |
| SPRY2 | uniprot |
| PLCG2 | uniprot |
| PLCG2 | uniprot |
| PTPN6 | uniprot |
| RAF1 | uniprot |
| GAB1 | uniprot |
| SHC1 | uniprot |
| PLD1 | uniprot |
| BCAR1 | uniprot |
| SH2D3C | uniprot |
| STXBP1 | uniprot |
| APPL | uniprot |
| APPL | uniprot |
| DIP13B | uniprot |
| STAT1 | uniprot |
| SRC | uniprot |
| CBL | uniprot |
| CRK | uniprot |
| CRKL | uniprot |
| NDUFA13 | uniprot |
| RAC1 | uniprot |
| PTK2B | uniprot |
| CAV1 | uniprot |
| CAV2 | uniprot |
| NCK1 | uniprot |
| NCK2 | uniprot |
| PLCG1 | uniprot |
| GIT1 | uniprot |
| RGS16 | uniprot |
| SOCS1 | uniprot |
| SOCS3 | uniprot |
| INPPL1 | |
| RAB5A | uniprot |
| USP6NL | uniprot |
| ARF4 | uniprot |
| ZNF259 | uniprot |
| RIPK1 | uniprot |
| MAP3K14 | uniprot |
| RALGDS | uniprot |
| RASA1 | uniprot |
| PTK6 | uniprot |
| PRKAR1A | uniprot |
| PTPN6 | uniprot |
| PTPN11 | uniprot |
| MAPK1 | uniprot |
| MAP2K1 | uniprot |
| DUSP1 | uniprot |
| DUSP1 | uniprot |
| ARF4 | uniprot |
| ARF4 | uniprot |
| EGF | uniprot |
| EGF | uniprot |
| SH3GL2 | uniprot |
| EGFR | uniprot |
| Molecular association | |
| Translocation | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Enzyme complex | |
| Plasma membrane | |
| Extracellular | |
| Gene Symbol | |
| PM | |
| CY | |
| PM | |
| NU | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| CY | |
| NU | |
| NU | |
| CY | |
| MA | |
| MA | |
| MA | |
| MA | |
| CY | |
| NU | |
| NU | |
| CY | |
| CY | |
| NU | |
| NU | |
| CY | |
| CY | |
| PM | |
| NU | |
| CY | |
| MA | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| CY | |
| NU | |
| PM | |
| CY | |
| PM | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| NU | |
| PM | |
| CY | |
| PM | |
| EN | |
| PM | |
| EN | |
| PM | |
| CY | |
| NU | |
| EC | |
| Proteins in a complex interaction | |
| (Protein-protein interaction) | |
| Autodephosphorylation | chemical |
| Acetylation | chemical |
| Accession Number : NetPath_4; cellmap:4 | |
| MA | |
| MA | |
| D | |
| D | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| MA | |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Desumoylation |
| PLA2G2A | uniprot | |
| PLA2G6 | uniprot | |
| PLA2G6 | uniprot | |
| ALOX5AP | uniprot | |
| ALOX5 | uniprot | |
| ALOX15 | uniprot | |
| ALOX5 | uniprot | |
| ALOX15 | uniprot | |
| Peroxidase? | ||
| DPEP1 | uniprot | |
| PTGIS | uniprot | |
| ALOX5AP | uniprot | |
| ALOX12 | uniprot | |
| ALOX15B | uniprot | |
| PTGS1 | uniprot | |
| PTGS2 | uniprot | |
| TBXAS1 | uniprot | |
| LTC4S | uniprot | |
| GGT1 | uniprot | |
| Peroxidase? | ||
| IPLA2(GAMMA) | ||
| LTA4H | uniprot | |
| PGE2 9-ketoreduc | ||
| PTGES | uniprot | |
| PTGES2 | uniprot | |
| PTGDS | uniprot | |
| Peroxidase? | ||
| PGD2 11-ketoreduc | ||
| Cell Membrane | ||
| Arachadonic Acid | chemical | |
| PGH2 | hmdbid:HMDB01381 | |
| 5-HPETE | ||
| 12-HPETE | ||
| 15-HPETE | ||
| 15-HETE | ||
| 12-HETE | CHEBI:19138 | |
| LTC4 | hmdbid:HMDB01198 | |
| LTD4 | CHEBI:28666 | |
| LTE4 | hmdbid:HMDB02200 | |
| PGI2 | hmdbid:HMDB01335 | uniprot |
| PGF2-alpha | chemical | |
| PGE2 | hmdbid:HMDB01220 | |
| PGD2 | hmdbid:HMDB01403 | |
| TXA2 | hmdbid:HMDB01452 | |
| Lipox = Lipoxygenase | ||
| ETE = Eicosatetraenoic Acid | ||
| HP = Hydroperoxy | ||
| H = Hydroxy | ||
| diH = Dihydroxy | ||
| PG = Prostaglandin | ||
| LT = Leukotriene | ||
| TX = Thromboxane | ||
| 6-KetoPGF2-alpha | chemical | |
| 5-HETE | CHEBI:28209 | |
| LTA4 | hmdbid:HMDB01337 | uniprot |
| LTB4 | uniprot | |
| TXA3 | ||
| TXB2 | CHEBI:28728 |
| ND2 | uniprot |
| ND3 | uniprot |
| ND4 | uniprot |
| ND5 | uniprot |
| ND6 | uniprot |
| ND4L | uniprot |
| COX2 | uniprot |
| COX3 | uniprot |
| COX4I1 | uniprot |
| COX5A | uniprot |
| COX5B | uniprot |
| COX6A2 | uniprot |
| COX6B1 | uniprot |
| COX7B | uniprot |
| COX7C | uniprot |
| COX8A | uniprot |
| UCP2 | uniprot |
| UCP3 | uniprot |
| SLC25A5 | uniprot |
| SLC25A6 | uniprot |
| SDHB | uniprot |
| NDUFAB1 | uniprot |
| NDUFB3 | uniprot |
| NDUFA6 | uniprot |
| NDUFB4 | uniprot |
| NDUFB6 | uniprot |
| NDUFB7 | uniprot |
| NDUFB9 | uniprot |
| NDUFA2 | uniprot |
| NDUFA3 | uniprot |
| NDUFB8 | uniprot |
| NDUFB10 | uniprot |
| NDUFC1 | uniprot |
| NDUFB1 | uniprot |
| NDUFS5 | uniprot |
| NDUFB5 | uniprot |
| ND1 | uniprot |
| NDUFA5 | uniprot |
| NDUFS7 | uniprot |
| NDUFS6 | uniprot |
| NDUFA8 | uniprot |
| NDUFS4 | uniprot |
| SDHC | uniprot |
| SDHD | uniprot |
| CYTB | uniprot |
| UQCRC1 | uniprot |
| UQCRC2 | uniprot |
| UQCRB | uniprot |
| UQCRH | uniprot |
| UQCRFS1 | uniprot |
| QP-C | uniprot |
| UCRC | |
| UQCR | uniprot |
| CYCS | uniprot |
| COX1 | uniprot |
| COX7A1 | uniprot |
| COX7A2L | uniprot |
| COX7A3 | uniprot |
| COX7A2 | uniprot |
| COX6C | uniprot |
| COX17 | uniprot |
| COX11 | uniprot |
| SCO1 | uniprot |
| SURF1 | uniprot |
| COX15 | uniprot |
| ATP5G1 | uniprot |
| ATP5G2 | uniprot |
| ATP5G3 | uniprot |
| ATP6 | uniprot |
| ATP5A1 | uniprot |
| ATP5B | uniprot |
| ATP5D | uniprot |
| ATP5E | uniprot |
| ATP5F1 | uniprot |
| ATP5C1 | uniprot |
| ATP5I | uniprot |
| ATP5J2 | uniprot |
| ATP5L | uniprot |
| ATP5O | uniprot |
| ATP5H | uniprot |
| ATP5S | uniprot |
| ATP5J | uniprot |
| ATP8 | uniprot |
| UCP1 | uniprot |
| SLC25A27 | uniprot |
| SLC25A14 | uniprot |
| ATPIF1 | uniprot |
| NDUFS8 | uniprot |
| NDUFV2 | uniprot |
| NDUFA9 | uniprot |
| NDUFA10 | uniprot |
| NDUFS2 | uniprot |
| NDUFV1 | uniprot |
| NDUFS1 | uniprot |
| NDUFB2 | uniprot |
| NDUFA4 | uniprot |
| DAP13 | uniprot |
| NDUFA7 | uniprot |
| NDUFC2 | uniprot |
| COX6A1 | uniprot |
| SDHA | uniprot |
| NDUFA1 | uniprot |
| NDUFV3 | uniprot |
| SLC25A4 | uniprot |
| NDUFS3 | uniprot |
| C subunit | |
| F1 Complex | |
| Stalk | |
| F0 Complex | |
| binds ATP Synthase beta | |
| Uncoupling Protein | |
| Complex I | uniprot |
| Complex IV | |
| Complex III | |
| Complex II | |
| NADH-Ubiquinone | chemical |
| Succinate-Ubiquinone | chemical |
| Oxidoreductase | enzyme |
| Ubiquinol-Cytochrome C | chemical |
| Reductase | enzyme |
| Cytochrome C | |
| Oxidase | |
| ATP Synthase (Complex V) | |
| Adenine Nucleotide | chemical |
| Translocator | |
| Ubiquinone | hmdbid:HMDB02012 |
| Assembly | |
| Oxidoreductase | enzyme |
| DAXX | uniprot |
| DAXX | uniprot |
| FASLG | uniprot |
| FAS | uniprot |
| HSPB1 | uniprot |
| TNF | uniprot |
| IL1A | uniprot |
| MAPKAPK2 | uniprot |
| MAPKAPK3 | uniprot |
| CYCS | uniprot |
| BCL2 | uniprot |
| CASP9 | uniprot |
| APAF1 | uniprot |
| APAF1 | uniprot |
| CASP3 | uniprot |
| HSPB1 | uniprot |
| HSPB1 | uniprot |
| HSPB1 | uniprot |
| HSPB1 | uniprot |
| HSPB1 | uniprot |
| HSPB1 | uniprot |
| HSPB1 | uniprot |
| actin | uniprot |
| FADD | uniprot |
| FAF1 | uniprot |
| FAF1 | uniprot |
| FAP1 | uniprot |
| CASP8 | uniprot |
| CASP8 | uniprot |
| CFLAR | uniprot |
| RIPK2 | uniprot |
| CASP10 | uniprot |
| CASP7 | uniprot |
| CASP3 | uniprot |
| PARP1 | uniprot |
| PAK1 | uniprot |
| PAK2 | uniprot |
| ARHGDIB | uniprot |
| SPTAN1 | uniprot |
| DFFA | uniprot |
| DFFB | uniprot |
| DFFB | uniprot |
| PRKDC | uniprot |
| CASP6 | uniprot |
| LMNA | uniprot |
| LMNB1 | uniprot |
| LMNB2 | uniprot |
| RB1 | uniprot |
| MAP3K1 | uniprot |
| MAP2K4 | uniprot |
| MAPK8 | uniprot |
| MAP3K7 | uniprot |
| JUN | uniprot |
| Stress | |
| Mitochondria Pathway | |
| Apoptosome | |
| Proteasome | enzyme |
| NFK-B | |
| Pathway | |
| ROS | CHEBI:26523 |
| Cell Survival | |
| Necrosis | |
| P | |
| Apoptosis | |
| FAS Pathway | |
| P | |
| P | |
| 3x-P | |
| 3x-P | |
| 3x-P | |
| DNA presentation | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| Ceramide | hmdbid:HMDB04957 |
| Extracellular | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Stress Induction of HSP regulation | |
| Cut | |
| Inhibition | chemical |
| Activate | |
| Self-activation | |
| Glutathione | hmdbid:HMDB00125 |
| TPI1 | uniprot | |
| GK | ||
| GK2 | enzyme | uniprot |
| GPD2 | uniprot | |
| CPT2 | uniprot | |
| CPT1A | uniprot | |
| CHKB | uniprot | |
| SLC25A20 | uniprot | |
| CRAT | uniprot | |
| ACSL1 | uniprot | |
| ACAS2 | uniprot | |
| ACSL3 | uniprot | |
| ACSL4 | uniprot | |
| ACSL5 | uniprot | |
| ACSL6 | uniprot | |
| CPT1B | uniprot | |
| ACADVL | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| HADHB | uniprot | |
| ACADL | uniprot | |
| HADHB | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| ECHS1 | uniprot | |
| HADHSC | uniprot | |
| HADHB | uniprot | |
| LIPE | uniprot | |
| LIPC | uniprot | |
| PNPLA2 | ||
| LIPF | uniprot | |
| LPL | enzyme | uniprot |
| HADHA | uniprot | |
| HADHA | uniprot | |
| ACADL | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| HADHA | uniprot | |
| Triacylglycerol | chemical | |
| Glycerol | hmdbid:HMDB00131 | |
| Dihydroxyacetone Phosphate | hmdbid:HMDB01473 | |
| Fatty Acid | CHEBI:35366 | |
| Acyl-CoA | CHEBI:17984 | |
| Palmitoyl-CoA | hmdbid:HMDB01338 | |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 | |
| L-Glycerol-3-Phosphate | chemical | |
| See Glycolysis MAPP | ||
| Trans-Hexadecanoyl-CoA | chemical | |
| (S)-3-Hydroxyhexadecanoyl-CoA | chemical | |
| 3-Oxopalmitoyl-CoA | hmdbid:HMDB06402 | |
| Myristoyl-CoA | CHEBI:15532 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Trans-Tetradex-2-enoyl-CoA | chemical | |
| (S)-3-Hydroxytetradecanoyl-CoA | chemical | |
| Dxotetradecanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Lauroyl-CoA | hmdbid:HMDB03571 | |
| 2-trans-dodecenoyl-CoA | CHEBI:15471 | |
| (S)-3-Hydroxydodexanonyl-CoA | chemical | |
| 3-Oxododexanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Decanoyl-CoA | CHEBI:28493 | |
| See Beta Oxidation 2 MAPP | ||
| Lipases | enzyme | uniprot |
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP |
| ACADM | uniprot | |
| ECHS1 | uniprot | |
| HADHSC | uniprot | |
| HADHB | uniprot | |
| ACADM | uniprot | |
| ECHS1 | uniprot | |
| HADHSC | uniprot | |
| HADHB | uniprot | |
| ACADS | uniprot | |
| ECHS1 | uniprot | |
| HADHSC | uniprot | |
| HADHB | uniprot | |
| HADHA | uniprot | |
| HADHA | uniprot | |
| HADHA | uniprot | |
| Decanoyl-CoA | CHEBI:28493 | |
| See Beta Oxidation 1 MAPP | ||
| Trans-Dec-2-enoyl-CoA | CHEBI:10723 | |
| (S)-3-Hydroxydecanoyl-CoA | chemical | |
| 3-Oxocanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Octaoyl-CoA | chemical | |
| Trans-Oct-2-enoyl-CoA | CHEBI:27537 | |
| (S)-3-Hydroxyoctanoyl-CoA | chemical | |
| 3-Oxo-octanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Hexanoyl-CoA | hmdbid:HMDB02845 | |
| See Beta Oxidation Unsaturated MAPP | ||
| (S)-Hydrocyhexanoyl | chemical | |
| 3-Oxohexanoyl-CoA | CHEBI:27648 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Butanoyl-CoA | hmdbid:HMDB01088 | |
| See Beta Oxidation 3 MAPP | ||
| Trans-Hex-2-enoyl-CoA | CHEBI:28706 | |
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP |
| ACADS | uniprot | |
| ECHS1 | uniprot | |
| HADHSC | uniprot | |
| GCDH | uniprot | |
| DLD | uniprot | |
| ACAT1 | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| Butanoyl-CoA | hmdbid:HMDB01088 | |
| See Beta Oxidation 2 | ||
| Cronoyl-CoA | chemical | |
| (S)-3-Hydroxybutanoyl-CoA | hmdbid:HMDB01166 | |
| Acetoacetyl-CoA | hmdbid:HMDB01484 | |
| Glutaryl-CoA | hmdbid:HMDB01339 | |
| Glutarate | hmdbid:HMDB00661 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| See TCA Cycle |
| LPL | enzyme | uniprot |
| GK | ||
| GK2 | enzyme | uniprot |
| GPD2 | uniprot | |
| TPI1 | uniprot | |
| ACSL1 | uniprot | |
| ACSL3 | uniprot | |
| ACSL4 | uniprot | |
| ACSL5 | uniprot | |
| ACSL6 | uniprot | |
| CRAT | uniprot | |
| CPT1A | uniprot | |
| CHKB | uniprot | |
| CPT2 | uniprot | |
| SLC25A20 | uniprot | |
| CPT1B | uniprot | |
| ACADVL | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| ACADL | uniprot | |
| ECHS1 | uniprot | |
| HADHSC | uniprot | |
| ACADM | uniprot | |
| ECHS1 | uniprot | |
| HADHA | uniprot | |
| HADHSC | uniprot | |
| HADHB | uniprot | |
| ACADS | uniprot | |
| ECHS1 | uniprot | |
| ACADS | uniprot | |
| HADHSC | uniprot | |
| ACAT1 | uniprot | |
| HADHA | uniprot | |
| HADHB | uniprot | |
| DLD | uniprot | |
| GCDH | uniprot | |
| LIPC | uniprot | |
| LIPE | uniprot | |
| LIPF | uniprot | |
| PNPLA2 | ||
| ACAS2 | uniprot | |
| Beta Oxidation 1 MAPP | ||
| Beta Oxidation 2 MAPP | ||
| Beta Oxidation 3 MAPP | ||
| This MAPP is only present for statistical purpose, | ||
| to help evaluate all beta-oxidation MAPPS at once. | ||
| Omit the 3 individual sub-mapps from statistical | ||
| evaluation to prevent redundancy. |
| CYP1A1 | uniprot |
| CYP1A2 | uniprot |
| CYP3A4 | uniprot |
| CYP4A11 | uniprot |
| CYP2A6 | uniprot |
| CYP2D6 | uniprot |
| CYP2E1 | uniprot |
| ADH1A | uniprot |
| ADH1B | uniprot |
| ADH1C | uniprot |
| ADH4 | uniprot |
| ADH6 | uniprot |
| ADH7 | uniprot |
| ALDH1A1 | uniprot |
| ALDH2 | uniprot |
| CH3-(CH2)10-COO- | |
| HO-CH-(CH2)10-COO- | |
| HOC-(CH2)10-COO- | |
| -OOC-(CH2)10-COO- | |
| Beta Oxidation |
| PC | ||
| ACLY | uniprot | |
| FASN | uniprot | |
| ACACB | uniprot | |
| ACACA | uniprot | |
| FASN | uniprot | |
| FASN | uniprot | |
| FASN | uniprot | |
| FASN | uniprot | |
| FASN | uniprot | |
| FASN | uniprot | |
| ACAA2 | uniprot | |
| HADHSC | uniprot | |
| SCD | uniprot | |
| ACSL1 | uniprot | |
| ACSL3 | uniprot | |
| ACSL4 | uniprot | |
| ACAS2 | uniprot | |
| ACSL5 | uniprot | |
| ACSL6 | uniprot | |
| FASN | uniprot | |
| ECHS1 | uniprot | |
| ECHDC3 | ||
| ECH1 | uniprot | |
| ECHDC2 | ||
| ECHDC1 | ||
| MECR | uniprot | |
| PECR | uniprot | |
| DECR1 | uniprot | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Pyruvate | hmdbid:HMDB00243 | |
| TCA Cycle | ||
| Mitochondrion | ||
| Cytosol | ||
| Citrate | hmdbid:HMDB00094 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Acetyl-ACP | chemical | |
| Acetyl-synthase | ||
| Malonyl-CoA | hmdbid:HMDB01175 | |
| Malonyl-ACP | chemical | |
| Acetoacetyl-ACP | chemical | |
| beta-hydroxybutyryl | chemical | |
| Crotonoyl-ACP | chemical | |
| Butyryl-ACP | chemical | |
| less than 6 iterations | ||
| Palmitoyl-ACP | chemical | |
| 6 iterations | ||
| Palmitate | hmdbid:HMDB00220 | |
| 3-ketoacyl-CoA | chemical | |
| 3-L-Hydroxyacyl-CoA | chemical | |
| trans-delta2-enoyl-CoA | chemical | |
| Acyl-CoA (n+2) | ||
| Long-Chain fatty acid | ||
| Fatty acyl CoA | ||
| See Triacylglyceride Synthesis MAPP |
| LIMK1 | uniprot | |
| GNA13 | uniprot | |
| ARHGEF1 | uniprot | |
| RHOA | uniprot | |
| PIK3R2 | uniprot | |
| DIAPH1 | uniprot | |
| PFN1 | uniprot | |
| PIP5K2A | uniprot | |
| MAPK10 | uniprot | |
| PKN1 | uniprot | |
| MYBPH | uniprot | |
| PPP1CB | uniprot | |
| ARHGDIB | uniprot | |
| RAC1 | uniprot | |
| MAP3K4 | uniprot | |
| PAK3 | uniprot | |
| MYL1 | uniprot | |
| CIT | hmdbid:HMDB00904 | uniprot |
| IQGAP1 | uniprot | |
| IQGAP2 | uniprot | |
| RPS6KB1 | uniprot | |
| ROCK1 | uniprot | |
| ROCK2 | uniprot | |
| SH3MD2 | ||
| PIK3CA | uniprot | |
| PIK3CB | uniprot | |
| PIK3CD | uniprot | |
| CFL2 | uniprot | |
| CFL1 | uniprot | |
| RTKN | uniprot | |
| RHPN2 | uniprot | |
| ARHGDIG | uniprot | |
| CALM1 | uniprot | |
| TNK2 | uniprot | |
| CDC42 | uniprot | |
| WASL | uniprot | |
| WAS | ||
| p140 Sra-1 | ||
| 13 | ||
| Activated Rho A | ||
| Cytokinesis | ||
| Stress Fiber Contraction | ||
| Interaction, Focal Adhesion | ||
| Contraction & Actin-Myosin | ||
| Actin | uniprot | |
| Membrane | ||
| Ruffling | ||
| Anti-Apoptotic | ||
| Actin Polymerization | ||
| Polymerization | chemical | |
| Filopodia Formation | ||
| Actin Reorganization | ||
| Stress Fiber | ||
| Disassembly of Actin | ||
| Cell-Cell Adhesion | ||
| G | ||
| Disappearance |
| GNAI1 | uniprot |
| PDE1B | uniprot |
| PDE1C | uniprot |
| PDE4A | uniprot |
| PDE4B | uniprot |
| PDE4C | uniprot |
| PDE4D | uniprot |
| PDE7A | uniprot |
| PDE7B | uniprot |
| PDE8A | uniprot |
| PDE8B | uniprot |
| GNB1 | uniprot |
| GNB2 | uniprot |
| GNB5 | uniprot |
| GNGT1 | uniprot |
| GNGT2 | uniprot |
| GNG3 | uniprot |
| GNG4 | uniprot |
| GNG5 | uniprot |
| GNG7 | uniprot |
| GNG8 | uniprot |
| GNG10 | uniprot |
| GNG11 | uniprot |
| GNG12 | uniprot |
| GNG13 | uniprot |
| GNAS | uniprot |
| GNAZ | uniprot |
| GNAI2 | uniprot |
| GNAI1 | uniprot |
| GNAO1 | uniprot |
| GNAI3 | uniprot |
| ADCY1 | uniprot |
| ADCY2 | uniprot |
| ADCY3 | uniprot |
| ADCY4 | uniprot |
| ADCY5 | uniprot |
| ADCY6 | uniprot |
| ADCY7 | uniprot |
| ADCY8 | uniprot |
| ADCY9 | uniprot |
| KCNJ3 | uniprot |
| GNAQ | uniprot |
| GNA11 | uniprot |
| GNA14 | uniprot |
| GNA15 | uniprot |
| PLCB3 | uniprot |
| ITPR1 | uniprot |
| HRAS | uniprot |
| NRAS | uniprot |
| KRAS | uniprot |
| KRAS | uniprot |
| RRAS | uniprot |
| PPP3CA | uniprot |
| PPP3CC | uniprot |
| PPP3CC | uniprot |
| PRKCD | uniprot |
| PRKCG | uniprot |
| PRKCE | uniprot |
| PRKCI | uniprot |
| PRKCH | uniprot |
| PRKD1 | uniprot |
| PRKCQ | uniprot |
| PRKCZ | uniprot |
| PRKCB1 | uniprot |
| PRKD3 | uniprot |
| GNA12 | uniprot |
| GNA13 | uniprot |
| ARHGEF1 | uniprot |
| RHOA | uniprot |
| SLC9A1 | uniprot |
| PRKAR2A | uniprot |
| PRKAR2B | uniprot |
| PRKACA | uniprot |
| PRKACB | uniprot |
| PRKACG | uniprot |
| PRKAR1A | uniprot |
| PRKAR1B | uniprot |
| PDE1A | uniprot |
| GNB3 | uniprot |
| GNAL | uniprot |
| GNAO1 | uniprot |
| CALM1 | uniprot |
| PRKCA | uniprot |
| AKAP1 | uniprot |
| AKAP2 | uniprot |
| AKAP3 | uniprot |
| AKAP4 | uniprot |
| AKAP5 | uniprot |
| AKAP6 | uniprot |
| AKAP10 | uniprot |
| AKAP9 | uniprot |
| AKAP8 | uniprot |
| AKAP7 | uniprot |
| AKAP11 | uniprot |
| AKAP12 | uniprot |
| AKAP13 | |
| cAMP | hmdbid:HMDB00058 |
| DAG | uniprot |
| Ca | |
| ++ | |
| G | |
| s | |
| G | |
| G | |
| G | |
| q | |
| i | |
| 12/13 | |
| Protein Kinase C | uniprot |
| Phosphatase 2B | |
| Protein Kinase A | uniprot |
| Adenylate Cyclases | uniprot |
| Phosphodiesterases | chemical |
| cAMP | hmdbid:HMDB00058 |
| beta & gamma | |
| G | |
| Transcription | |
| Transcription | |
| Cell | |
| Response | |
| Cell | |
| Response | |
| Cytoskeletal | |
| Changes | |
| IP3 | |
| AKAPs |
| 20b-Hydroxysteroid Dh | |
| 3a-Hydroxysteroid Dh | |
| 3-Oxo-5b-Steroid Dh | |
| (R)20-hydroxysteroid Dh | |
| 3a-Hydroxysteroid Dh | |
| Cortisone beta-reductase | |
| Corticosterone 18-Monooxy | |
| HSD11B1 | uniprot |
| CYP11B2 | uniprot |
| CYP21A2 | uniprot |
| CYP17A1 | uniprot |
| HSD3B1 | uniprot |
| 3B-OH-delta-Steroid Dh | |
| HSD3B2 | uniprot |
| CYP17A1 | uniprot |
| CYP11A1 | uniprot |
| HSD3B1 | uniprot |
| HSD11B2 | uniprot |
| HO | |
| O | |
| HO | |
| Cholesterol | hmdbid:HMDB00067 |
| From Cholersterol Biosynthesis | |
| Progesterone | hmdbid:HMDB01830 |
| Signaling | |
| Steroid Hormone | CHEBI:26764 |
| Pregnenolone | hmdbid:HMDB00253 |
| 17-a-OH-Pregnenolone | chemical |
| HO | |
| =O | |
| CH | |
| OH | |
| 17-a-OH-Progesterone | chemical |
| To Androgen Synthesis | |
| and Metabolism | |
| Substrates in | |
| 11-Deoxycorticosterone | hmdbid:HMDB00016 |
| C | |
| =O | |
| CH | |
| C | |
| =O | |
| CH | |
| C | |
| O | |
| =O | |
| CH | |
| C | |
| 3 | |
| 3 | |
| 3 | |
| 2 | |
| OH | |
| HO | |
| OH | |
| =O | |
| CH | |
| C | |
| 3 | |
| O | |
| O | |
| =O | |
| CH | |
| C | |
| 2 | |
| OH | |
| HO | |
| OH | |
| 11-Deoxycortisol | hmdbid:HMDB00015 |
| Cortisol | hmdbid:HMDB00063 |
| Cortisone | hmdbid:HMDB02802 |
| 18-Hydroxy-Corticosterone | chemical |
| O | |
| =O | |
| CH | |
| C | |
| 2 | |
| OH | |
| C | |
| O | |
| H | |
| HO | |
| Aldosterone | hmdbid:HMDB00037 |
| 5b-Pregnan-18-al | chemical |
| 3a,11b,21-Trihydroxy-20-Oxo- | chemical |
| 5b-Pregnan-18-al | chemical |
| 11b, 21-Dihydroxy-3,20- | |
| 17a,21-Dihydroxy-5b- | chemical |
| Pregnane-3,11,20-trione | chemical |
| Urocortisone | hmdbid:HMDB00903 |
| Urocortisol | hmdbid:HMDB00949 |
| Cortisol | hmdbid:HMDB00063 |
| Cortolone | hmdbid:HMDB03180 |
| Pregnane 3,20-dione | hmdbid:HMDB03759 |
| 11b,17a 21-Trihydroxy-5b | |
| Glucuronides | hmdbid:HMDB03141 |
| 3a-OH-5b-Pregnane-20-one | chemical |
| 5b-Pregnane-3,20-dione | hmdbid:HMDB03759 |
| HO | |
| CH | |
| C | |
| 3 | |
| H | |
| H | |
| Corticosterone | hmdbid:HMDB01547 |
| -OH | |
| Pregnanediol | hmdbid:HMDB04025 |
| Glucocorticoids | CHEBI:24261 |
| Progesterone Degradation | |
| teal | |
| have strucutures shown |
| 1.8.1.13 | ||
| ANPEP | uniprot | |
| GGT1 | uniprot | |
| GPX3 | uniprot | |
| 1.8.4.4 | ||
| 1.8.4.1 | ||
| 2.8.1.3 | ||
| 1.8.5.1 | ||
| 1.8.4.3 | ||
| 1.8.3.3 | ||
| 1.11.1.12 | ||
| 1.8.4.7 | ||
| 1.8.4.2 | ||
| 1.5.4.1 | ||
| G6PD | enzyme | uniprot |
| 1.1.1.43 | ||
| IDH1 | uniprot | |
| GSR | uniprot | |
| GSS | uniprot | |
| GCLC | uniprot | |
| GGT1 | uniprot | |
| 3.4.11.4 | ||
| ANPEP | uniprot | |
| OPLAH | uniprot | |
| 2.3.2.4 | ||
| GGT1 | uniprot | |
| 2.3.2.4 | ||
| 2.3.1.80 | ||
| 6.3.1.8 | ||
| 3.5.1.78 | ||
| GPX1 | uniprot | |
| GPX2 | uniprot | |
| GPX4 | uniprot | |
| GSTA5 | uniprot | |
| GSTA1 | uniprot | |
| GSTM1 | uniprot | |
| GSTT1 | uniprot | |
| GSTT2 | uniprot | |
| GSTM2 | uniprot | |
| GGTLA1 | uniprot | |
| GGTLA1 | uniprot | |
| GCLM | uniprot | |
| GGTLA1 | uniprot | |
| Glutamate metabolism | ||
| Taurine and hypotaurine | ||
| Cyanoamino | chemical | |
| Cysteine metabolism | ||
| Amino acid metabolism | ||
| L-Amino Acid | CHEBI:15705 | |
| 5-Oxoproline | hmdbid:HMDB00267 | |
| L-Cysteine | hmdbid:HMDB00574 | |
| L-Glutamate | hmdbid:HMDB00148 | |
| Glycine | hmdbid:HMDB00123 | |
| Cysteinyl-Glycine | chemical | |
| (5-L-Glutamyl) | ||
| Glutathione | hmdbid:HMDB00125 | |
| g-L-Glutamyl-L-cysteine | hmdbid:HMDB01049 | |
| Bis-g-glutamylcystine | chemical | |
| Gluthatione | ||
| NADPH | hmdbid:HMDB00221 | |
| NADP+ | hmdbid:HMDB00217 | |
| RX | ||
| R-S-Glutathione | CHEBI:17021 | |
| Glutamylcysteinyl- | chemical | |
| L-Glutamate | hmdbid:HMDB00148 | |
| R-S-Alanyl | chemical | |
| Glycine | hmdbid:HMDB00123 | |
| R-S-Alanine | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| R-S-Mercapturonate | chemical | |
| (reduced) | ||
| glycylspermidine | chemical | |
| glycine | hmdbid:HMDB00123 | |
| metabolism | ||
| acid metabolism | ||
| g-Glutamyl | chemical | |
| Cycle | ||
| -L-amino acid | chemical | |
| glutathione recycling | ||
| Glutathione utilization | ||
| Glutathione | hmdbid:HMDB00125 | |
| utilization | ||
| (oxidized) |
| GSK3B | uniprot | ||
| GBE1 | uniprot | ||
| GYS1 | uniprot | ||
| GYS2 | uniprot | ||
| AGL | uniprot | ||
| PYGM | uniprot | ||
| PYGB | uniprot | ||
| PYGL | uniprot | ||
| PGM1 | uniprot | ||
| UGP2 | uniprot | ||
| UGP2 | uniprot | ||
| GYG | uniprot | ||
| GYG2 | uniprot | ||
| PHKA1 | uniprot | ||
| PHKA2 | uniprot | ||
| PHKB | uniprot | ||
| PHKG1 | uniprot | ||
| PHKG2 | uniprot | ||
| CALM2 | uniprot | ||
| GSK3A | uniprot | ||
| PPP2CB | uniprot | ||
| PPP2R5B | uniprot | ||
| PPP2R5D | uniprot | ||
| PPP2R5A | uniprot | ||
| PPP2R5E | uniprot | ||
| PPP2R5C | uniprot | ||
| PPP2R1A | uniprot | ||
| PPP2R2A | uniprot | ||
| PPP2R2B | uniprot | ||
| PPP2R2C | uniprot | ||
| PPP2R3A | uniprot | ||
| PPP2R3B | uniprot | ||
| PPP2CA | uniprot | ||
| PPP2R4 | uniprot | ||
| CALM1 | uniprot | ||
| CALM3 | uniprot | ||
| PPP2R1B | uniprot | ||
| Glycogen | hmdbid:HMDB00757 | ||
| Glucose | hmdbid:HMDB00122 | ||
| Glucose-6-phosphate | hmdbid:HMDB01401 | ||
| Glucose-1-phosphate | hmdbid:HMDB01586 | ||
| Glycogen (n+1) | |||
| UDP-Glucose + | |||
| Glycogen | hmdbid:HMDB00757 | ||
| Glycolysis | |||
| Glycogen (n-1) + Glucose-1-phosphate | |||
| Degradation | |||
| Synthesis | |||
| cAMP | hmdbid:HMDB00058 | ||
| Ser/Thr Protein Phosphatase 2A | |||
| Phosphorylase Kinase | enzyme |
| CHRM1 | uniprot | |
| CHRM2 | uniprot | |
| CHRM3 | uniprot | |
| CHRM4 | uniprot | |
| CHRM5 | uniprot | |
| ADRA1B | uniprot | |
| ADRA1A | uniprot | |
| ADRA1D | uniprot | |
| ADRA2C | uniprot | |
| ADRA2B | uniprot | |
| ADRA2A | uniprot | |
| ADRB1 | uniprot | |
| ADRB2 | uniprot | |
| ADRB3 | uniprot | |
| DRD1 | uniprot | |
| DRD5 | uniprot | |
| DRD2 | uniprot | |
| DRD3 | uniprot | |
| DRD4 | uniprot | |
| HRH1 | uniprot | |
| HRH2 | uniprot | |
| HRH3 | uniprot | |
| HTR1E | uniprot | |
| HTR1F | uniprot | |
| HTR1D | uniprot | |
| HTR1B | uniprot | |
| HTR1A | uniprot | |
| HTR2B | uniprot | |
| HTR2C | uniprot | |
| HTR2A | uniprot | |
| HTR4 | uniprot | |
| HTR5A | uniprot | |
| HTR6 | uniprot | |
| HTR7 | uniprot | |
| AGTR1 | uniprot | |
| AGTR2 | uniprot | |
| NMBR | uniprot | |
| BRS3 | uniprot | |
| GRPR | uniprot | |
| BDKRB2 | uniprot | |
| BDKRB1 | uniprot | |
| C3AR1 | uniprot | |
| GPR77 | uniprot | |
| FPRL2 | uniprot | |
| FPR1 | uniprot | |
| FPRL1 | uniprot | |
| AGTRL1 | uniprot | |
| IL8RA | uniprot | |
| IL8RB | uniprot | |
| CCR1 | uniprot | |
| CCR2 | uniprot | |
| CCR3 | uniprot | |
| CCR4 | uniprot | |
| CCR5 | uniprot | |
| CCR6 | uniprot | |
| CCR8 | uniprot | |
| CCR9 | uniprot | |
| CCBP2 | uniprot | |
| CCRL2 | uniprot | |
| CXCR3 | uniprot | |
| CXCR4 | uniprot | |
| BLR1 | uniprot | |
| CX3CR1 | uniprot | |
| CCKAR | uniprot | |
| CCKBR | uniprot | |
| CCR10 | uniprot | |
| CCRL1 | uniprot | |
| CCR7 | uniprot | |
| XCR1 | uniprot | |
| EDNRA | uniprot | |
| EDNRB | uniprot | |
| MC1R | uniprot | |
| MC2R | uniprot | |
| MC4R | uniprot | |
| MC5R | uniprot | |
| MC3R | uniprot | |
| NPY1R | uniprot | |
| NPY2R | uniprot | |
| PPYR1 | uniprot | |
| NPY5R | uniprot | |
| NPY6R | uniprot | |
| GPR83 | uniprot | |
| NTSR2 | uniprot | |
| NTSR1 | uniprot | |
| OPRD1 | uniprot | |
| OPRK1 | uniprot | |
| OPRM1 | uniprot | |
| OPRL1 | uniprot | |
| SSTR1 | uniprot | |
| SSTR2 | uniprot | |
| SSTR3 | uniprot | |
| SSTR4 | uniprot | |
| SSTR5 | uniprot | |
| F2R | uniprot | |
| AVPR2 | uniprot | |
| AVPR1A | uniprot | |
| AVPR1B | uniprot | |
| OXTR | uniprot | |
| GALR1 | uniprot | |
| GALR3 | uniprot | |
| GALR2 | uniprot | |
| F2RL1 | uniprot | |
| F2RL2 | uniprot | |
| F2RL3 | uniprot | |
| HCRTR2 | uniprot | |
| HCRTR1 | uniprot | |
| GPR74 | uniprot | |
| GPR147 | uniprot | |
| GPR37 | uniprot | |
| GPR37L1 | uniprot | |
| GPR32 | uniprot | |
| CMKLR1 | uniprot | |
| GPR44 | uniprot | |
| GPR30 | uniprot | |
| NMUR2 | uniprot | |
| NMUR1 | uniprot | |
| FSHR | uniprot | |
| LHCGR | uniprot | |
| RHO | uniprot | |
| OPN1MW | uniprot | |
| OPN1LW | uniprot | |
| OPN1SW | uniprot | |
| OPN3 | uniprot | |
| OPN4 | uniprot | |
| RRH | uniprot | |
| Rgr | uniprot | |
| OR7A17 | uniprot | |
| Q9UDD9 | ||
| OR7C1 | uniprot | |
| OR7A10 | uniprot | |
| OR7A5 | uniprot | |
| OR1Q1 | uniprot | |
| OR1I1 | uniprot | |
| OR1F1 | uniprot | |
| OR1E2 | uniprot | |
| OR1E1 | uniprot | |
| OR1D4 | uniprot | |
| OR1A1 | uniprot | |
| OR1D2 | uniprot | |
| OR1C1 | uniprot | |
| OR1A2 | uniprot | |
| OR7C2 | uniprot | |
| OR1G1 | uniprot | |
| OR2J1 | uniprot | |
| OR10A5 | uniprot | |
| OR10A4 | uniprot | |
| OR2N1P | ||
| OR5V1 | uniprot | |
| OR2W1 | uniprot | |
| OR2S2 | uniprot | |
| OR2H2 | uniprot | |
| OR2B3 | uniprot | |
| OR2J3 | uniprot | |
| OR2J2 | uniprot | |
| OR2B2 | uniprot | |
| OR2B6 | uniprot | |
| OR2C1 | uniprot | |
| OR2D2 | uniprot | |
| OR2F1 | uniprot | |
| OR2F2 | uniprot | |
| OR2H1 | uniprot | |
| OR2A4 | uniprot | |
| OR3A1 | uniprot | |
| OR3A3 | uniprot | |
| OR3A4 | uniprot | |
| OR8B8 | uniprot | |
| OR8D2 | uniprot | |
| OR5F1 | uniprot | |
| OR5I1 | uniprot | |
| OR6B1 | uniprot | |
| OR11A1 | uniprot | |
| OR6A2 | uniprot | |
| OR10H2 | uniprot | |
| OR10H3 | uniprot | |
| OR10H1 | uniprot | |
| OR10J1 | uniprot | |
| OR2T1 | uniprot | |
| OR5U1 | uniprot | |
| PTGER1 | uniprot | |
| PTGER2 | uniprot | |
| PTGDR | uniprot | |
| PTGER3 | uniprot | |
| PTGER4 | uniprot | |
| PTGFR | uniprot | |
| PTGIR | uniprot | |
| TBXA2R | uniprot | |
| ADORA1 | uniprot | |
| MLNR | uniprot | |
| GPR50 | uniprot | |
| MTNR1A | uniprot | |
| MTNR1B | uniprot | |
| P2RY13 | uniprot | |
| GPR87 | uniprot | |
| P2RY12 | uniprot | |
| P2RY14 | uniprot | |
| GPR27 | uniprot | |
| GPR85 | uniprot | |
| GPR173 | uniprot | |
| MAS1 | uniprot | |
| CMKOR1 | uniprot | |
| GPR1 | uniprot | |
| GPR31 | uniprot | |
| GPR24 | uniprot | |
| GPR25 | uniprot | |
| GPR12 | uniprot | |
| GPR4 | uniprot | |
| ADORA2A | uniprot | |
| ADORA2B | uniprot | |
| ADORA3 | uniprot | |
| P2RY2 | uniprot | |
| P2RY1 | uniprot | |
| P2RY6 | uniprot | |
| P2RY4 | uniprot | |
| LTB4R | uniprot | |
| GPR92 | uniprot | |
| P2RY11 | uniprot | |
| GPR174 | uniprot | |
| GPR23 | uniprot | |
| P2RY5 | uniprot | |
| P2RY10 | uniprot | |
| GPR35 | uniprot | |
| SUCNR1 | uniprot | |
| CNR2 | uniprot | |
| CNR1 | uniprot | |
| PTAFR | uniprot | |
| TRHR | uniprot | |
| GHSR | uniprot | |
| GPR22 | uniprot | |
| GPR15 | uniprot | |
| GPR10 | uniprot | |
| GPR8 | uniprot | |
| GPR7 | uniprot | |
| GPR6 | uniprot | |
| GPR3 | uniprot | |
| GPR52 | uniprot | |
| GPR17 | uniprot | |
| GPR21 | uniprot | |
| GPR19 | uniprot | |
| GPR20 | uniprot | |
| GPR63 | uniprot | |
| OR2AG1 | uniprot | |
| OR12D3 | uniprot | |
| OR1D5 | uniprot | |
| OR3A2 | uniprot | |
| GPR45 | uniprot | |
| CYSLTR1 | uniprot | |
| CYSLTR2 | uniprot | |
| GPR43 | uniprot | |
| GPR42 | uniprot | |
| GPR40 | uniprot | |
| GPR41 | uniprot | |
| GPR18 | uniprot | |
| GPR68 | uniprot | |
| GPR34 | uniprot | |
| GPR171 | uniprot | |
| GPR109B | uniprot | |
| MAS1L | uniprot | |
| GPR65 | uniprot | |
| GPR161 | uniprot | |
| GPR75 | uniprot | |
| GPR81 | uniprot | |
| GPR39 | uniprot | |
| Amine | CHEBI:32952 | |
| Acetylcholine (muscarinic) | ||
| Adrenoceptors | ||
| Alpha Adrenoceptors | ||
| Beta Adrenoceptors | ||
| Dopamine | hmdbid:HMDB00073 | |
| Histamine | hmdbid:HMDB00870 | |
| Serotonin | hmdbid:HMDB00259 | |
| Peptide | CHEBI:16670 CHEBI:16670 | |
| Angiotensin | uniprot | |
| Bombesin | uniprot | |
| Bradykinin | uniprot | |
| C5a anaphylatoxin | uniprot | |
| Fmet-leu-phe | ||
| APJ like | ||
| Interleukin-8 | uniprot | |
| Chemokine | ||
| C-C Chemokine | ||
| C-X-C Chemokine | ||
| BONZO receptors (CXC6R) | ||
| CCK | uniprot | |
| Other Chemokine Receptors | ||
| Endothelin | ||
| Melanocortin | chemical | |
| Neuropeptide Y | uniprot | |
| Neuropeptide Y / peptide YY | ||
| Opioid | ||
| Somatostatin | ||
| Vasopressin-like | ||
| Orexin & neuropeptide FF | ||
| Adrenomedullin (G10D) | ||
| Chemokine receptor-like | ||
| Neuromedin U | ||
| Hormone protein | ||
| Follicle stimulating hormone | ||
| Lutropin-choriogonadotropic hormone | ||
| (Rhod)opsin | ||
| Rhodopsin Vertebrate | ||
| Rhodopsin Other | ||
| Olfactory | ||
| Prostaglandin | CHEBI:26333 | |
| Nucleotide-like | ||
| Adenosine | hmdbid:HMDB00050 | |
| Melatonin | hmdbid:HMDB01389 | |
| Class A Orphan/other | ||
| Platelet ADP & KI01 receptors | ||
| SREB | ||
| Mas proto-oncogene | ||
| ORPH | ||
| LGR like (hormone receptors) | ||
| Purinoceptors | ||
| Purinoceptor type Y | ||
| Cannabis | ||
| Platelet activating factor | ||
| Thyrotropin-releasing hormone & Secretagogue | ||
| GPR45 like | ||
| Thrombin | enzyme | uniprot |
| Olfactory Other | ||
| GP40 like | ||
| Class A Orphans |
| CALCR | uniprot |
| CALCRL | uniprot |
| CRHR1 | uniprot |
| CRHR2 | uniprot |
| GIPR | uniprot |
| GLP2R | uniprot |
| GLP1R | uniprot |
| GCGR | uniprot |
| GHRHR | uniprot |
| PTHR2 | uniprot |
| PTHR1 | uniprot |
| ADCYAP1R1 | uniprot |
| SCTR | uniprot |
| VIPR1 | uniprot |
| VIPR2 | uniprot |
| CD97 | uniprot |
| EMR1 | uniprot |
| CD97 | uniprot |
| EMR2 | uniprot |
| LPHN1 | uniprot |
| LPHN2 | uniprot |
| LPHN3 | uniprot |
| ELTD1 | uniprot |
| GPR64 | uniprot |
| Calcitonin | uniprot |
| Corticotropin releasing factor | uniprot |
| Gastric inhibitory peptide | |
| Glucagon | uniprot |
| Growth hormone-releasing hormone | uniprot |
| Parathyroid hormone | |
| PACAP | uniprot |
| Secretin | uniprot |
| Vasoactive intestinal polypeptide | uniprot |
| Diuretic hormone | uniprot |
| EMR1 | uniprot |
| Latrophilin | |
| Class B orphan/other |
| GRM1 | uniprot |
| GRM5 | uniprot |
| GRM2 | uniprot |
| GRM3 | uniprot |
| GRM8 | uniprot |
| GRM4 | uniprot |
| GRM7 | uniprot |
| GRM6 | uniprot |
| CASR | uniprot |
| GABBR1 | uniprot |
| GPR51 | uniprot |
| GPRC5D | uniprot |
| GPRC5C | uniprot |
| GPRC5B | uniprot |
| GPRC5A | uniprot |
| Metabotropic glutamate | chemical |
| Metabotropic glutamate other | |
| GABA-B | |
| Orphan GPRC5 |
| PTCH2 | uniprot |
| SHH | uniprot |
| CDC2 | uniprot |
| PTCH | uniprot |
| PTCH2 | uniprot |
| DHH | uniprot |
| SMO | uniprot |
| IHH | uniprot |
| PTCH | uniprot |
| PTCH2 | uniprot |
| IHH | uniprot |
| GLI3 | uniprot |
| SKI | uniprot |
| SUFU | uniprot |
| SAP18 | uniprot |
| SIN3A | uniprot |
| GLI1 | uniprot |
| GAS1 | uniprot |
| CREBBP | uniprot |
| DYRK1A | uniprot |
| GLI2 | uniprot |
| STK36 | uniprot |
| SUFU | uniprot |
| CDC2 | uniprot |
| CCNB1 | uniprot |
| GLI1 | uniprot |
| GLI2 | uniprot |
| GLI3 | uniprot |
| PTCH | uniprot |
| SUFU | uniprot |
| RAB23 | uniprot |
| RAB23 | uniprot |
| CCNB1 | uniprot |
| SMOH | uniprot |
| IGF2 | uniprot |
| DHH | uniprot |
| SHH | uniprot |
| SHH | uniprot |
| DHH | uniprot |
| IHH | uniprot |
| SHH | uniprot |
| HHIP | uniprot |
| HHIP | uniprot |
| HHIP | uniprot |
| PTCH | uniprot |
| Translocation | |
| Plasma membrane | |
| Cytoplasm | |
| Endosome | |
| Nucleus | CHEBI:33252 |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| PM->EN | |
| CY->NU | |
| CY->PM | |
| PM->EN | |
| Molecular Association | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| Gene Symbol | |
| Activation | chemical |
| D | |
| Inhibition | chemical |
| Accession Number: NetPath_10; cellmap:10 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| EN | |
| NU | |
| D | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Methylation | chemical |
| Demethylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Extracellular | |
| EC | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Palmitoylation | chemical |
| Glycosylation |
| MAP3K1 | uniprot |
| CASP8 | uniprot |
| CASP3 | uniprot |
| FADD | uniprot |
| BID | uniprot |
| CASP2 | uniprot |
| CASP6 | uniprot |
| CASP7 | uniprot |
| FAS | uniprot |
| CASP8 | uniprot |
| PDCD8 | uniprot |
| CYCS | uniprot |
| APAF1 | uniprot |
| CASP9 | uniprot |
| CYCS | uniprot |
| NFKB1 | uniprot |
| FADD | uniprot |
| TNFRSF1A | uniprot |
| RIPK1 | uniprot |
| MAPK10 | uniprot |
| HSPA1A | uniprot |
| HSPA1A | uniprot |
| HSPA1A | uniprot |
| TNF-alpha | uniprot |
| STRESS | |
| Mitochondria | |
| APOPTOSIS | |
| CELL SURVIVAL | |
| Ik alpha | |
| degradation of | |
| Activation | chemical |
| of proteins | |
| degradation | |
| (activation of NFkB) | |
| Inhibition | chemical |
| Apoptosome | |
| Inhibition | chemical |
| NF-kB | |
| FAS-Ligand | |
| Proteasome | enzyme |
| pathway | |
| Inhibition | chemical |
| Inhibition | chemical |
| TCF8 | uniprot |
| MYOG | uniprot |
| IL1A | uniprot |
| ? | |
| EIF4E | uniprot |
| ATF3 | uniprot |
| IFNG | uniprot |
| DUSP14 | uniprot |
| NR4A3 | uniprot |
| MINOR | uniprot |
| WDR1 | uniprot |
| JUND | uniprot |
| IL1R1 | uniprot |
| CYR61 | uniprot |
| GDF8 | uniprot |
| EIF4EBP1 | uniprot |
| VEGF | uniprot |
| IL18 | uniprot |
| ADAM10 | uniprot |
| IFRD1 | uniprot |
| ANKRD1 | uniprot |
| HBEGF | uniprot |
| -634 | |
| -698 | |
| +1 | |
| ? | |
| angiogenesis | |
| protein synthesis | |
| proliferative response | |
| +500 | |
| +296 | |
| correlate to all 4 MINOR probes | |
| HB-EGF correlated |
| ID1 | uniprot | |
| ID2 | uniprot | |
| ID3 | uniprot | |
| ID4 | uniprot | |
| ID2 | uniprot | |
| RB1 | uniprot | |
| RBL2 | uniprot | |
| RBL1 | uniprot | |
| TCF3 | uniprot | |
| MYOD1 | uniprot | |
| CDK2 | uniprot | |
| CCNA2 | uniprot | |
| CCNE1 | uniprot | |
| ELK1 | uniprot | |
| ELK4 | uniprot | |
| ELK3 | uniprot | |
| PSMD4 | uniprot | |
| HES1 | uniprot | |
| PAX5 | uniprot | |
| PAX2 | uniprot | |
| PAX8 | uniprot | |
| MYF5 | uniprot | |
| MYF6 | uniprot | |
| MYOG | uniprot | |
| TCF12 | uniprot | |
| SREBF1 | uniprot | |
| MSC | uniprot | |
| IFI16 | uniprot | |
| BMP2 | uniprot | |
| BMPR2 | uniprot | |
| VEGF | uniprot | |
| FLT1 | uniprot | |
| KDR | hmdbid:HMDB06226 | uniprot |
| SMAD1 | uniprot | |
| SMAD4 | uniprot | |
| SMAD5 | uniprot | |
| ATF3 | uniprot | |
| SMAD3 | uniprot | |
| TGFB1 | uniprot | |
| ACVRL1 | uniprot | |
| SMAD4 | uniprot | |
| SMAD5 | uniprot | |
| SMAD1 | uniprot | |
| TCR | ||
| LCK | uniprot | |
| RAS | uniprot | |
| MAPK | enzyme | uniprot |
| ERK | enzyme | uniprot |
| IGF1R | uniprot | |
| IGF1 | uniprot | |
| IRS1 | uniprot | |
| PI3K | uniprot | |
| CTNNB1 | uniprot | |
| TERT | uniprot | |
| NFKB1 | uniprot | |
| RELA | uniprot | |
| BMP6 | uniprot | |
| CD40LG | uniprot | |
| NGFB | uniprot | |
| ATF3 | uniprot | |
| SMAD3 | uniprot | |
| EGF | uniprot | |
| TCF7L2 | uniprot | |
| Gene Symbol | ||
| ID Gene Regulation | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| Control | ||
| Ligand | ||
| Receptor | ||
| Molecule in the Pathway | ||
| P | ||
| P | ||
| P | ||
| CY -> NU | ||
| Cytoplasm | ||
| Extracellular | ||
| Proteins in a complex interaction | ||
| Molecular association | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| Phosphorylation | chemical | |
| Activation | chemical | |
| Translocation | ||
| CY | ||
| EC | ||
| Accession Number: NetPath_5; cellmap:5 | ||
| Enzyme complex | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Sumoylation | chemical | |
| Desumoylation | ||
| Ubiquitination | ||
| Deubiquitination | ||
| Inhibition | chemical | |
| Recruitment | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi apparatus | ||
| Mitochondria | ||
| MT | ||
| Nucleus | CHEBI:33252 | |
| NU | ||
| PM | ||
| Plasma membrane |
| IL1B | uniprot | |
| IL1RN | uniprot | |
| IL1RAP | uniprot | |
| IL1R1 | uniprot | |
| IL1A | uniprot | |
| IL1B | uniprot | |
| IL1RN | uniprot | |
| IL1R2 | uniprot | |
| IL1R2 | uniprot | |
| IL1RAP | uniprot | |
| IL1R2 | uniprot | |
| MYD88 | uniprot | |
| IRAK1 | uniprot | |
| IRAK4 | uniprot | |
| IL1R1 | uniprot | |
| IL1R1 | uniprot | |
| IRAK4 | uniprot | |
| IRAK3 | uniprot | |
| IRAK1 | uniprot | |
| TOLLIP | uniprot | |
| PELI1 | uniprot | |
| TRAF6 | uniprot | |
| IRAK1 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP2 | uniprot | |
| TRAF6 | uniprot | |
| MAP3K7IP2 | uniprot | |
| TRAF6 | uniprot | |
| MAP3K7 | uniprot | |
| IRAK1 | uniprot | |
| TRAF6 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7 | uniprot | |
| MAPK8 | uniprot | |
| MAP3K14 | uniprot | |
| CHUK | enzyme | uniprot |
| CHUK | enzyme | uniprot |
| IKBKAP | uniprot | |
| SQSTM1 | uniprot | |
| PRKCZ | uniprot | |
| SIRPA | uniprot | |
| PTPN11 | uniprot | |
| TOLLIP | uniprot | |
| IL1A | uniprot | |
| IRAK2 | uniprot | |
| IRAK4 | uniprot | |
| PELI1 | uniprot | |
| MAP3K14 | uniprot | |
| IRAK1 | uniprot | |
| IL1A | uniprot | |
| IL1B | uniprot | |
| CAPN1 | uniprot | |
| CAPNS1 | uniprot | |
| CASP1 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP2 | uniprot | |
| SIRPA | uniprot | |
| MAPK1 | uniprot | |
| AKT1 | uniprot | |
| IRAK1 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7 | uniprot | |
| TRAF6 | uniprot | |
| MAP3K7IP2 | uniprot | |
| TRAF6 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP1 | uniprot | |
| NFKBIA | uniprot | |
| NFKBIB | uniprot | |
| Gene Symbol | ||
| IL1A | uniprot | |
| IL1B | uniprot | |
| PTPN11 | uniprot | |
| MAPK1 | uniprot | |
| MAP2K1 | uniprot | |
| MAPK3 | uniprot | |
| NFKBIA | uniprot | |
| RELA | uniprot | |
| RELA | uniprot | |
| NFKB1 | uniprot | |
| PLCG1 | uniprot | |
| D | ||
| CY -> NU | ||
| PM -> CY | ||
| PM -> CY | ||
| D | ||
| D | ||
| D | ||
| Receptor | ||
| Ligand | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| Enzyme complex | ||
| Molecular association | ||
| Reaction through unknown mechanisms/molecules | ||
| Phosphorylation | chemical | |
| Autophosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Palmitoylation | chemical | |
| Ubiquitination | ||
| Proteolytic cleavage | ||
| Glycosylation | ||
| Acetylation | chemical | |
| Sumoylation | chemical | |
| Methylation | chemical | |
| Activation | chemical | |
| Inhibition | chemical | |
| Translocation | ||
| PM | ||
| CY | ||
| Cytoplasm | ||
| NU | ||
| EN | ||
| Endosome | ||
| GO | ||
| Golgi apparatus | ||
| MT | ||
| Mitochondria | ||
| CY->EX | ||
| CY->EX | ||
| Deubiquitination | ||
| Deacetylation | chemical | |
| Desumoylation | ||
| Demethylation | chemical | |
| Extracellular | ||
| D | ||
| D | ||
| D | ||
| CY -> NU | ||
| CY -> NU | ||
| (Protein-protein interaction) | ||
| EC | ||
| Nucleus | CHEBI:33252 | |
| Recruitment | ||
| Control | ||
| Plasma membrane | ||
| Accession Number: NetPath_13 |
| IL2RG | uniprot | |
| IL2RB | uniprot | |
| IL2RA | uniprot | |
| IL2 | uniprot | |
| IL2 | uniprot | |
| IL2 | uniprot | |
| JAK1 | uniprot | |
| JAK3 | uniprot | |
| JAK2 | uniprot | |
| LCK | uniprot | |
| PIK3R1 | uniprot | |
| PIK3R2 | uniprot | |
| PTPN6 | uniprot | |
| MAPK1 | uniprot | |
| MAPK3 | uniprot | |
| GAB2 | uniprot | |
| SYK | uniprot | |
| IRS1 | uniprot | |
| IRS2 | uniprot | |
| STAM2 | uniprot | |
| STAM | uniprot | |
| SOCS3 | uniprot | |
| PLCB1 | uniprot | |
| RPS6KB1 | uniprot | |
| PIK3CA | uniprot | |
| PIK3CB | uniprot | |
| PIK3CD | uniprot | |
| PIK3CG | uniprot | |
| FYN | uniprot | |
| AKT1 | uniprot | |
| FOXO3A | uniprot | |
| TERT | uniprot | |
| LYN | uniprot | |
| PTPN11 | uniprot | |
| SHC1 | uniprot | |
| RAF1 | uniprot | |
| GRB2 | uniprot | |
| PTK2B | uniprot | |
| CD53 | uniprot | |
| ICAM1 | uniprot | |
| SOS1 | uniprot | |
| SOCS1 | uniprot | |
| CISH | uniprot | |
| GNB2L1 | uniprot | |
| CRKL | uniprot | |
| CBL | uniprot | |
| SHB | uniprot | |
| CRK | uniprot | |
| NMI | uniprot | |
| ETS1 | uniprot | |
| ETS2 | uniprot | |
| NR3C1 | uniprot | |
| PRKCZ | uniprot | |
| ITM2B | uniprot | |
| BCL2 | uniprot | |
| IFNA1 | uniprot | |
| FRAP1 | uniprot | |
| HSPCA | uniprot | |
| MKNK1 | uniprot | |
| EIF4E | uniprot | |
| CREB1 | uniprot | |
| MAP2K1 | uniprot | |
| MAP2K2 | uniprot | |
| VAV1 | uniprot | |
| STAT5A | uniprot | |
| STAT5B | uniprot | |
| MAPK1 | uniprot | |
| MAPK3 | uniprot | |
| NFKB1 | uniprot | |
| RELA | uniprot | |
| NSEP1 | uniprot | |
| NFKB1 | uniprot | |
| RELA | uniprot | |
| NSEP1 | uniprot | |
| TERT | uniprot | |
| AKT1 | uniprot | |
| RAF1 | uniprot | |
| KRAS | uniprot | |
| MAPK8 | uniprot | |
| MAPK14 | uniprot | |
| MAPKAPK2 | uniprot | |
| MAPK9 | uniprot | |
| CHUK | enzyme | uniprot |
| EIF3S9 | uniprot | |
| AKT1 | uniprot | |
| STAT3 | uniprot | |
| STAT5A | uniprot | |
| STAT5B | uniprot | |
| STAT1 | uniprot | |
| CRK | uniprot | |
| IL2 | uniprot | |
| IL2 | uniprot | |
| Molecular association | ||
| Translocation | ||
| Autophosphorylation | chemical | |
| Phosphorylation | chemical | |
| Inhibition | chemical | |
| Activation | chemical | |
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| CY -> NU | ||
| CY -> NU | ||
| CY -> NU | ||
| CY -> NU | ||
| CY -> NU | ||
| CY -> NU | ||
| CY -> NU | ||
| CY -> PM | ||
| CY -> NU | ||
| PM -> CY | ||
| D | ||
| D | ||
| Ligand | ||
| Receptor | ||
| Molecule in the pathway | ||
| D | ||
| D | ||
| D | ||
| Gene Symbol | ||
| Accession Number: NetPath_14 | ||
| Proteins in a complex interaction | ||
| Enzyme complex | ||
| Reactions through unknown mechanisms/molecules | ||
| Plasma membrane | ||
| Nucleus | CHEBI:33252 | |
| (Protein-protein interaction) | ||
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitolyation | chemical | |
| Phosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Desumoylation | ||
| Ubiquitination | ||
| Deubiquitination | ||
| Sumoylation | chemical | |
| Recruitment | ||
| Control | ||
| CY | ||
| EC | ||
| EN | ||
| ER | ||
| GO | ||
| MT | ||
| PM | ||
| Cytoplasm | ||
| Extracellular | ||
| Endoplasmic reticulum | ||
| Endosome | ||
| Golgi apparatus | ||
| Mitochondrion | ||
| NU | ||
| NU | ||
| Nucleus | CHEBI:33252 | |
| MT |
| IL3 | uniprot |
| IL3RA | uniprot |
| IL3 | uniprot |
| IL3 | uniprot |
| CSF2RB | uniprot |
| IL3RA | uniprot |
| CSF2RB | uniprot |
| PIK3CA | uniprot |
| PIK3CD | uniprot |
| HRAS | uniprot |
| TEC | |
| VAV1 | uniprot |
| JAK1 | uniprot |
| JAK2 | uniprot |
| PTPN6 | uniprot |
| PTPN11 | uniprot |
| LYN | uniprot |
| SYK | uniprot |
| HCK | uniprot |
| FYN | uniprot |
| LCK | uniprot |
| STAT1 | uniprot |
| STAT5A | uniprot |
| STAT6 | uniprot |
| STAT5B | uniprot |
| STAT3 | uniprot |
| RARA | uniprot |
| RXRA | uniprot |
| PIK3R1 | uniprot |
| PIK3R2 | uniprot |
| AKT1 | uniprot |
| YWHAZ | uniprot |
| FES | uniprot |
| CISH | uniprot |
| GNB2L1 | uniprot |
| PRKCB1 | uniprot |
| SHC1 | uniprot |
| YWHAQ | uniprot |
| YWHAB | uniprot |
| GAB2 | uniprot |
| GRB2 | uniprot |
| SOS1 | uniprot |
| INPP5D | |
| GAB1 | uniprot |
| RAPGEF1 | uniprot |
| CRKL | uniprot |
| CBL | uniprot |
| CRK | uniprot |
| PILRB | uniprot |
| BAD | uniprot |
| BCL2L1 | uniprot |
| BCL2 | uniprot |
| BAX | uniprot |
| BCL2L11 | uniprot |
| PPP2CA | uniprot |
| CREB1 | uniprot |
| PTK2 | uniprot |
| PXN | uniprot |
| SRC | uniprot |
| SOCS2 | uniprot |
| SOCS3 | uniprot |
| DNM1 | uniprot |
| VCL | uniprot |
| RAF1 | uniprot |
| MAP2K1 | uniprot |
| RAC1 | uniprot |
| RAC2 | uniprot |
| MAPK8 | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| GATA1 | uniprot |
| GATA2 | uniprot |
| PRKACA | uniprot |
| PAK1 | uniprot |
| SHC1 | uniprot |
| PRKCA | uniprot |
| PRKCA | uniprot |
| NFKB1 | uniprot |
| NFKB1 | uniprot |
| SLC2A1 | uniprot |
| SLC2A1 | uniprot |
| BAD | uniprot |
| MAPK3 | uniprot |
| TYK2 | uniprot |
| GSK3A | uniprot |
| GSK3B | uniprot |
| KCNIP3 | uniprot |
| MAPK7 | uniprot |
| FOXO1A | uniprot |
| HSPB1 | uniprot |
| MAPK14 | uniprot |
| ATF2 | uniprot |
| ATF1 | uniprot |
| MRAS | uniprot |
| KRAS | uniprot |
| RPS6KB2 | uniprot |
| RAP1A | uniprot |
| BIRC5 | uniprot |
| MAPKAPK2 | uniprot |
| SPI1 | uniprot |
| CDC42 | uniprot |
| BMX | uniprot |
| TNFRSF1B | uniprot |
| ID1 | uniprot |
| SELP | uniprot |
| FCER2 | uniprot |
| MAPK9 | uniprot |
| CHEK1 | uniprot |
| MATK | uniprot |
| MMP2 | uniprot |
| MMP9 | uniprot |
| Gene Symbol | |
| IL3 | uniprot |
| Molecular Association | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| D | |
| CY->PM | |
| CY->NU | |
| CY->PM | |
| CY->NU | |
| D | |
| D | |
| Activation | chemical |
| Plasma membrane | |
| CY->PM | |
| D | |
| MT->CY | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Mitochondrion | |
| Accession Number: NetPath_15 | |
| Molecule in the pathway | |
| Receptor | |
| Ligand | |
| Proteins in a complex interaction | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| Translocation | |
| Inhibition | chemical |
| PM | |
| CY | |
| NU | |
| MT | |
| Enzyme complex | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Dephosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Deacetylation | chemical |
| Acetylation | chemical |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA |
| IL2RG | uniprot |
| IL4R | uniprot |
| IL4 | uniprot |
| FES | uniprot |
| INPP5D | |
| PTPN6 | uniprot |
| PTPN11 | uniprot |
| JAK1 | uniprot |
| IRS1 | uniprot |
| IL4 | uniprot |
| IL4R | uniprot |
| IL13RA1 | uniprot |
| JAK2 | uniprot |
| TYK2 | uniprot |
| JAK1 | uniprot |
| PIK3R1 | uniprot |
| PIK3R2 | uniprot |
| PRKCZ | uniprot |
| STAT6 | uniprot |
| PAWR | uniprot |
| IRS2 | uniprot |
| JAK3 | uniprot |
| GRB2 | uniprot |
| SOS1 | uniprot |
| CXCR4 | uniprot |
| ADRBK2 | uniprot |
| PTK2 | uniprot |
| SHC1 | uniprot |
| PLCG1 | uniprot |
| HIST2H3C | uniprot |
| CREBBP | uniprot |
| EP300 | uniprot |
| MAPK14 | uniprot |
| MAPK11 | uniprot |
| ATF2 | uniprot |
| CBL | uniprot |
| STAT6 | uniprot |
| STAT6 | uniprot |
| STAT5A | uniprot |
| SOCS5 | uniprot |
| STAT6 | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| MAPK14 | uniprot |
| DOK2 | uniprot |
| RASA1 | uniprot |
| NFKB1 | uniprot |
| RELA | uniprot |
| BAD | uniprot |
| NCF1 | uniprot |
| PIK3CA | uniprot |
| PIK3CD | uniprot |
| BCL2L1 | uniprot |
| SOCS1 | uniprot |
| RPS6KB1 | uniprot |
| HMGA1 | uniprot |
| ETS1 | uniprot |
| SOCS3 | uniprot |
| STAT1 | uniprot |
| SRC | uniprot |
| ELK1 | uniprot |
| AKT1 | uniprot |
| PRKCD | uniprot |
| PRKD3 | uniprot |
| PRKCI | uniprot |
| PRKCD | uniprot |
| PRKD3 | uniprot |
| PRKCI | uniprot |
| PRKCZ | uniprot |
| NFKB1 | uniprot |
| SPI1 | uniprot |
| LCK | uniprot |
| FYN | uniprot |
| STAM | uniprot |
| STAT6 | uniprot |
| JAK2 | uniprot |
| Gene Symbol | |
| Translocation | |
| Cytoplasm | |
| Plasma membrane | |
| Nucleus | CHEBI:33252 |
| CY -> NU | |
| D | |
| D | |
| D | |
| D | |
| CY -> PM | |
| CY -> PM | |
| CY -> PM | |
| CY -> PM | |
| CY -> NU | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| D | |
| Inhibition | chemical |
| D | |
| Accession Number: NetPath_16 | |
| Proteins in a complex interaction | |
| Molecular association | |
| Reaction through unknown mechanisms/molecules | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Activation | chemical |
| (Protein-protein interaction) | |
| Acetylation | chemical |
| PM | |
| CY | |
| NU | |
| Enzyme complex | |
| Autophosphorylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Control |
| IL5 | uniprot |
| IL5 | uniprot |
| IL5RA | uniprot |
| CSF2RB | uniprot |
| SHC1 | uniprot |
| PTPN11 | uniprot |
| CSF2RB | uniprot |
| DNM2 | uniprot |
| PRKCB1 | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| SHC2 | uniprot |
| MAPK14 | uniprot |
| NFKBIA | uniprot |
| PTK2B | uniprot |
| PIK3CG | uniprot |
| MAP2K2 | uniprot |
| PIK3R1 | uniprot |
| PIK3R2 | uniprot |
| PTPN6 | uniprot |
| NFKB1 | uniprot |
| MAPK9 | uniprot |
| GRB2 | uniprot |
| LYN | uniprot |
| UNC119 | uniprot |
| CRKL | uniprot |
| RAF1 | uniprot |
| KRAS | uniprot |
| SYK | uniprot |
| SDCBP | uniprot |
| SOX4 | uniprot |
| SOCS1 | uniprot |
| YWHAZ | uniprot |
| HCK | uniprot |
| AKT1 | uniprot |
| RPS6KA1 | uniprot |
| FOXO3A | uniprot |
| NFKB1 | uniprot |
| GSK3A | uniprot |
| PLA2G4A | uniprot |
| VAV1 | uniprot |
| HCLS1 | uniprot |
| CBL | uniprot |
| APS | uniprot |
| JUN | uniprot |
| BTK | uniprot |
| GSK3B | uniprot |
| ATF2 | uniprot |
| ELK1 | uniprot |
| IL2RB | uniprot |
| STAT5A | uniprot |
| STAT5B | uniprot |
| CRKL | uniprot |
| ALOX5 | uniprot |
| ALOX5 | uniprot |
| BAX | uniprot |
| BAX | uniprot |
| PRKCD | uniprot |
| PRKCD | uniprot |
| IL5RA | uniprot |
| CSF2RB | uniprot |
| CTNNB1 | uniprot |
| CTNNB1 | uniprot |
| HRAS | uniprot |
| RAP1GAP | uniprot |
| CCND3 | uniprot |
| CDKN1B | uniprot |
| RAPGEF1 | uniprot |
| ALOX5AP | uniprot |
| RAC1 | uniprot |
| ICAM1 | uniprot |
| ICAM3 | uniprot |
| ITGB2 | uniprot |
| ITGAM | uniprot |
| PIM1 | uniprot |
| JAK1 | uniprot |
| JAK2 | uniprot |
| STAT3 | uniprot |
| STAT1 | uniprot |
| STAT5B | uniprot |
| STAT5A | uniprot |
| (Protein-protein interaction) | |
| Translocation | |
| Autophosphorylation | chemical |
| Recruitment | |
| Inhibition | chemical |
| Activation | chemical |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Plasma membrane | |
| Control | |
| Ubiquitination | |
| Mitochondria | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->MT | |
| CY->PM | |
| PM->NU | |
| PM->NU | |
| PM->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| Gene Symbol | |
| D | |
| Accession Number: NetPath_17 | |
| Molecular association | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| NU | |
| MT | |
| D | |
| D | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO |
| IL6 | uniprot |
| IL6R | uniprot |
| IL6R | uniprot |
| IL6ST | uniprot |
| IL6ST | uniprot |
| FES | uniprot |
| TEC | |
| BTK | uniprot |
| JAK2 | uniprot |
| PTPN11 | uniprot |
| JAK1 | uniprot |
| TYK2 | uniprot |
| SHC1 | uniprot |
| GRB2 | uniprot |
| STAT3 | uniprot |
| SOS1 | uniprot |
| VAV1 | uniprot |
| MAPK1 | uniprot |
| GAB1 | uniprot |
| PIK3R1 | uniprot |
| PIK3R2 | uniprot |
| STAT1 | uniprot |
| STAT1 | uniprot |
| STAT1 | uniprot |
| STAT3 | uniprot |
| STAT1 | uniprot |
| STAT3 | uniprot |
| STAT3 | uniprot |
| STAT3 | uniprot |
| MAPK14 | uniprot |
| MAPK14 | uniprot |
| SGK | uniprot |
| SGK | uniprot |
| NFKB1 | uniprot |
| NFKB1 | uniprot |
| NLK | uniprot |
| HRAS | uniprot |
| NCOA1 | uniprot |
| CREBBP | uniprot |
| RAC1 | uniprot |
| CDK9 | uniprot |
| DAXX | uniprot |
| AR | |
| HDAC1 | uniprot |
| PRKCD | uniprot |
| PTK2B | uniprot |
| GAB2 | uniprot |
| MAP2K4 | uniprot |
| HSP90AA1 | uniprot |
| SOCS3 | uniprot |
| FOS | uniprot |
| JUN | uniprot |
| TCF1 | uniprot |
| CEBPB | uniprot |
| ERBB2 | uniprot |
| ERBB3 | uniprot |
| HCK | uniprot |
| LYN | uniprot |
| CEBPB | uniprot |
| RAF1 | uniprot |
| CASP3 | uniprot |
| CASP9 | uniprot |
| PPP2CA | uniprot |
| PPP2CB | uniprot |
| PPP2R1A | uniprot |
| PPP2R1B | uniprot |
| PPP2R2A | uniprot |
| PPP2R2B | uniprot |
| PPP2R2C | uniprot |
| PPP2R3A | uniprot |
| PPP2R3B | uniprot |
| PPP2R4 | uniprot |
| PPP2R5A | uniprot |
| PPP2R5B | uniprot |
| PPP2R5C | uniprot |
| PPP2R5D | uniprot |
| PPP2R5E | uniprot |
| EP300 | uniprot |
| MAP2K6 | uniprot |
| CDK5 | uniprot |
| MAPT | uniprot |
| RPS6KA2 | uniprot |
| MAPK3 | uniprot |
| FGR | uniprot |
| PLCG1 | uniprot |
| MAP3K4 | uniprot |
| RB1 | uniprot |
| AKT1 | uniprot |
| BAD | uniprot |
| GSK3B | uniprot |
| FOXO1A | uniprot |
| MAP2K1 | uniprot |
| MAP2K2 | uniprot |
| EIF4E | uniprot |
| EIF2A | uniprot |
| MAPK8 | uniprot |
| PTK2 | uniprot |
| PXN | uniprot |
| FOXO3A | uniprot |
| MLLT7 | uniprot |
| INPP5D | |
| INPPL1 | |
| RPS6KB1 | uniprot |
| EIF4EBP1 | uniprot |
| BMX | uniprot |
| FYN | uniprot |
| CD40 | uniprot |
| STAT3 | uniprot |
| STAT5A | uniprot |
| STAT5B | uniprot |
| STAT3 | uniprot |
| STAT3 | uniprot |
| MAPKAPK2 | uniprot |
| MAP3K7 | uniprot |
| MAP3K7 | uniprot |
| HSPB1 | uniprot |
| IL6 | uniprot |
| CDK5R1 | uniprot |
| Autophosphorylation | chemical |
| Early Endosomes | |
| Inhibition | chemical |
| Translocation | |
| Cytoplasm | |
| CY->NU | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Acetylation | chemical |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY->EN | |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| CY->NU | |
| Activation | chemical |
| Complex formation | |
| Gene Symbol | |
| D | |
| D | |
| Accession Number: NetPath_18 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-Protein interaction) | |
| D | |
| Reactions through unknown mechanisms/molecules | |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| CY | |
| Extracellular | |
| EC | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| NU | |
| Nucleus | CHEBI:33252 |
| PM | |
| Plasma membrane | |
| Molecular association |
| IL7 | uniprot |
| IL7R | uniprot |
| JAK3 | uniprot |
| IL2RG | uniprot |
| JAK1 | uniprot |
| FYN | uniprot |
| LYN | uniprot |
| STAT5A | uniprot |
| STAT5B | uniprot |
| STAT3 | uniprot |
| PIK3R1 | uniprot |
| PTK2B | uniprot |
| IRS1 | uniprot |
| IRS2 | uniprot |
| AKT1 | uniprot |
| STAT1 | uniprot |
| STAM2 | uniprot |
| STAM | uniprot |
| BAX | uniprot |
| BAD | uniprot |
| FOXO3A | uniprot |
| GSK3B | uniprot |
| FOXO1A | uniprot |
| RB1 | uniprot |
| CCND2 | uniprot |
| CCNA2 | uniprot |
| CDK4 | uniprot |
| CDK2 | uniprot |
| CLTC | uniprot |
| BCL2L11 | uniprot |
| MCL1 | uniprot |
| BLK | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| CBLB | uniprot |
| SHC1 | uniprot |
| GRB2 | uniprot |
| SOS1 | uniprot |
| CBL | uniprot |
| IRF1 | uniprot |
| MUC1 | uniprot |
| Gene Symbol | |
| HRAS | uniprot |
| RAF1 | uniprot |
| MAP2K1 | uniprot |
| MAP2K2 | uniprot |
| D | |
| D | |
| D | |
| PM | |
| CY | |
| NU | |
| EN | |
| GO | |
| MT | |
| Plasma membrane | |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| Molecular association | |
| Reaction through unknown mechanisms/molecules | |
| Phosphorylation | chemical |
| Autophosphorylation | chemical |
| Dephosphorylation | chemical |
| Palmitoylation | chemical |
| Ubiquitination | |
| Proteolytic cleavage | |
| Glycosylation | |
| Acetylation | chemical |
| Sumoylation | chemical |
| Methylation | chemical |
| Recruitment | |
| Activation | chemical |
| Inhibition | chemical |
| Translocation | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Endosome | |
| Golgi apparatus | |
| Mitochondrion | |
| Accession Number: NetPath_19 | |
| EC | |
| Extracellular | |
| Deacetylation | chemical |
| Demethylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Control |
| IL9 | uniprot |
| IL9R | uniprot |
| IL2RG | uniprot |
| IRS1 | uniprot |
| PIK3R1 | uniprot |
| IRS2 | uniprot |
| GRB2 | uniprot |
| HTATIP | uniprot |
| STAT3 | uniprot |
| STAT3 | uniprot |
| JAK1 | uniprot |
| VCP | uniprot |
| JAK3 | uniprot |
| MAP2K2 | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| MAP2K1 | uniprot |
| SHC1 | uniprot |
| STAT1 | uniprot |
| STAT5A | uniprot |
| STAT5B | uniprot |
| AKT1 | uniprot |
| PTPN11 | uniprot |
| TYK2 | uniprot |
| SOCS3 | uniprot |
| Molecular association | |
| CY->NU | |
| Translocation | |
| CY | |
| NU | |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| D | |
| Reaction through unknown mechanisms/molecules | |
| D | |
| D | |
| D | |
| Inhibition | chemical |
| Receptor | |
| Ligand | |
| Activation | chemical |
| Accession Number: NetPath_20 | |
| Gene Symbol | |
| Molecule in the pathway | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Proteins in a complex interaction | |
| Proteins in a complex interaction | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| PM | |
| Plasma membrane | |
| (Protein-protein interaction) |
| COL1A1 | uniprot |
| COL1A2 | uniprot |
| COL3A1 | uniprot |
| FN1 | uniprot |
| LAMA5 | uniprot |
| LAMB1 | uniprot |
| LAMB2 | uniprot |
| LAMC1 | uniprot |
| LAMC2 | uniprot |
| VTN | uniprot |
| THBS3 | uniprot |
| THBS1 | uniprot |
| IFNG | uniprot |
| IL5 | uniprot |
| IL4 | uniprot |
| IL2 | uniprot |
| TNFRSF1B | uniprot |
| TNFRSF1A | uniprot |
| IL2RG | uniprot |
| IL2RB | uniprot |
| IL2RA | uniprot |
| ZAP70 | uniprot |
| LCK | uniprot |
| CD28 | uniprot |
| CD40 | uniprot |
| CD86 | uniprot |
| CD80 | uniprot |
| CD40LG | uniprot |
| IL4R | uniprot |
| IL5RA | uniprot |
| IGHA2 | uniprot |
| IgM | |
| IGHA1 | uniprot |
| Early Response | |
| Blood or Lymph | |
| Inflammation | |
| Epithelium | |
| Fibroblast | |
| Fibrotic Response | |
| B-cell | |
| TH-cell |
| INSR | uniprot | |
| IGF1R | uniprot | |
| IRS1 | uniprot | |
| IRS4 | ||
| PIK3CA | uniprot | |
| PIK3CB | uniprot | |
| PIK3CG | uniprot | |
| PIK3CD | uniprot | |
| PIK3R1 | uniprot | |
| PIK3R2 | uniprot | |
| PIK3R3 | uniprot | |
| PIK3R4 | uniprot | |
| PIK3C2A | uniprot | |
| PIK3C3 | uniprot | |
| PIK3C2G | uniprot | |
| PDPK1 | uniprot | |
| AKT1 | uniprot | |
| AKT2 | uniprot | |
| GSK3B | uniprot | |
| GSK3A | uniprot | |
| SLC2A4 | uniprot | |
| PTEN | uniprot | |
| PRKCI | uniprot | |
| PRKCZ | uniprot | |
| PSCD3 | uniprot | |
| ARF6 | uniprot | |
| ARF1 | uniprot | |
| INPP4A | uniprot | |
| TRIB3 | uniprot | |
| FOXO1A | uniprot | |
| PFKM | uniprot | |
| GYS1 | uniprot | |
| GAB1 | uniprot | |
| SHC1 | uniprot | |
| GRB2 | uniprot | |
| PTPN11 | uniprot | |
| SOS1 | uniprot | |
| SOS2 | uniprot | |
| RAF1 | uniprot | |
| MAP2K1 | uniprot | |
| MAP2K2 | uniprot | |
| MAP2K3 | uniprot | |
| MAP2K4 | uniprot | |
| MAP2K5 | uniprot | |
| MAP2K6 | uniprot | |
| MAP3K1 | uniprot | |
| MAP3K2 | uniprot | |
| MAP3K3 | uniprot | |
| MAP3K4 | uniprot | |
| MAPK3 | uniprot | |
| MAPK4 | uniprot | |
| MAPK1 | uniprot | |
| MAPK6 | uniprot | |
| MAPK13 | uniprot | |
| MAPK9 | uniprot | |
| MAPK10 | uniprot | |
| MAP4K1 | uniprot | |
| MAP3K5 | uniprot | |
| MAP3K10 | uniprot | |
| MAPK8 | uniprot | |
| MAPK14 | uniprot | |
| MAP3K8 | uniprot | |
| MAP3K12 | uniprot | |
| MAP4K2 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K11 | uniprot | |
| MAPK11 | uniprot | |
| MAP3K9 | uniprot | |
| MAP4K4 | uniprot | |
| MAPK7 | uniprot | |
| MAP3K13 | uniprot | |
| MAP4K3 | uniprot | |
| MAP3K6 | uniprot | |
| MINK1 | uniprot | |
| MAPK12 | uniprot | |
| MAP4K5 | uniprot | |
| MAP3K14 | uniprot | |
| RPS6KB1 | uniprot | |
| RPS6KA2 | uniprot | |
| RPS6KA3 | uniprot | |
| RPS6KB2 | uniprot | |
| RPS6KA1 | uniprot | |
| RPS6KA5 | uniprot | |
| RPS6KA6 | uniprot | |
| RPS6KA4 | uniprot | |
| PPP1R3A | uniprot | |
| PTPRF | uniprot | |
| CBL | uniprot | |
| CBLB | uniprot | |
| CBLC | uniprot | |
| RAPGEF1 | uniprot | |
| CAP1 | uniprot | |
| SORBS1 | uniprot | |
| RHOJ | uniprot | |
| SNX26 | uniprot | |
| RHOQ | uniprot | |
| CRK | uniprot | |
| FLOT1 | uniprot | |
| FLOT2 | uniprot | |
| PTPN1 | uniprot | |
| FRAP1 | uniprot | |
| EIF4E | uniprot | |
| EIF4EBP1 | uniprot | |
| LIPE | uniprot | |
| GYS2 | uniprot | |
| EGR1 | uniprot | |
| FOS | uniprot | |
| JUN | uniprot | |
| SLC2A1 | uniprot | |
| GRB10 | uniprot | |
| SHC3 | uniprot | |
| HRAS | uniprot | |
| RRAD | uniprot | |
| INPPL1 | ||
| PRKCA | uniprot | |
| PRKCB1 | uniprot | |
| PRKCQ | uniprot | |
| PRKCH | uniprot | |
| PRKCD | uniprot | |
| ENPP1 | uniprot | |
| GYG | uniprot | |
| PFKL | uniprot | |
| TSC1 | uniprot | |
| RHEB | uniprot | |
| TSC2 | uniprot | |
| RAB4A | uniprot | |
| STXBP4 | uniprot | |
| VAMP2 | uniprot | |
| SNAP25 | uniprot | |
| SNAP23 | uniprot | |
| EHD1 | uniprot | |
| EHD2 | uniprot | |
| MYO1C | uniprot | |
| KIF5B | uniprot | |
| KIF3A | uniprot | |
| SGK | uniprot | |
| SGK2 | uniprot | |
| SGKL | uniprot | |
| FOXO3A | uniprot | |
| TBC1D4 | uniprot | |
| ELK1 | uniprot | |
| SRF | uniprot | |
| GRB14 | uniprot | |
| STXBP1 | uniprot | |
| STXBP2 | uniprot | |
| STXBP3 | uniprot | |
| STX4A | uniprot | |
| MAPK8 | uniprot | |
| SOCS1 | uniprot | |
| SOCS3 | uniprot | |
| PRKAA1 | uniprot | |
| PRKAA2 | uniprot | |
| IKBKB | enzyme | uniprot |
| XBP1 | uniprot | |
| RAC1 | uniprot | |
| RAC2 | uniprot | |
| IRS3 | ||
| IRS2 | uniprot | |
| SHC2 | uniprot | |
| MAP2K7 | uniprot | |
| APS | uniprot | |
| Glucose Transport | ||
| Modulators of Insulin Action | ||
| MEK/MAP Kinases | ||
| Insulin Receptor Substrates | ||
| PI 3-Kinase | ||
| p90 Rsk Kinases | ||
| Transcriptional Regulators & Immediate Early Genes | ||
| Vesicular Trafficking | ||
| p70 S6 Kinases | ||
| Metabolic Regulation | ||
| Ras-MAPK Signaling | ||
| PDK/Akt Signaling | ||
| Tor Signaling | ||
| Translation Regulation |
| CES2 | uniprot |
| CES1 | uniprot |
| Irinotecan | chemical |
| SN-38 | |
| CYP3A4 | uniprot |
| CYP3A5 | uniprot |
| M4 | |
| APC | uniprot |
| NPC | uniprot |
| CYP3A4 | uniprot |
| CYP3A5 | uniprot |
| CYP3A4 | uniprot |
| CES1 | uniprot |
| CES2 | uniprot |
| SN-38 | |
| UGT1A1 | uniprot |
| UGT1A9 | uniprot |
| ABCC1 | uniprot |
| ABCC2 | uniprot |
| SN-38 | |
| CES1 | uniprot |
| CES2 | uniprot |
| ABCC1 | uniprot |
| ABCC2 | uniprot |
| ABCG2 | uniprot |
| UGT1A6 | uniprot |
| UGT1A1 | uniprot |
| UGT1A10 | uniprot |
| SN-38G | |
| CES2 | uniprot |
| CES1 | uniprot |
| BCHE | uniprot |
| ABCC2 | uniprot |
| UGT1A6 | uniprot |
| ABCC1 | uniprot |
| SN-38 | |
| Irinotecan | chemical |
| Irinotecan | chemical |
| Neutropenia | |
| Liver Cell | |
| Diarrhea | |
| Intestine | |
| Model human liver cell showing blood, bile and | |
| intestinal compartments, indicating tissue | |
| involvment of genes in the irinotecan pathway. |
| GRB7 | uniprot |
| PIK3R1 | uniprot |
| PIK3R2 | uniprot |
| SHC1 | uniprot |
| CSF2RB | uniprot |
| GRB2 | uniprot |
| SOCS6 | uniprot |
| SOCS4 | uniprot |
| SOCS5 | uniprot |
| CISH | uniprot |
| CLTC | uniprot |
| CRK | uniprot |
| SRC | uniprot |
| PLCE1 | uniprot |
| JAK2 | uniprot |
| GRAP | uniprot |
| PTPRU | uniprot |
| STAP1 | uniprot |
| PRKCA | uniprot |
| PLCG1 | uniprot |
| STAT1 | uniprot |
| STAT5A | uniprot |
| STAT5B | uniprot |
| PIK3CG | uniprot |
| APS | uniprot |
| GRB10 | uniprot |
| AKT1 | uniprot |
| TEC | |
| LYN | uniprot |
| DOK1 | uniprot |
| PTPN6 | uniprot |
| PTPN11 | uniprot |
| EPOR | uniprot |
| RPS6KA1 | uniprot |
| MITF | uniprot |
| MAPK1 | uniprot |
| ABL1 | uniprot |
| INPP5D | |
| FGR | uniprot |
| HCK | uniprot |
| YES1 | uniprot |
| RASA1 | uniprot |
| FES | uniprot |
| CRKL | uniprot |
| CBL | uniprot |
| SOCS1 | uniprot |
| VAV1 | uniprot |
| VAV2 | uniprot |
| MATK | uniprot |
| BAD | uniprot |
| SOS1 | uniprot |
| EP300 | uniprot |
| FYN | uniprot |
| PRKCB1 | uniprot |
| HRAS | uniprot |
| RAF1 | uniprot |
| SPRED2 | uniprot |
| SPRED1 | uniprot |
| SH3KBP1 | uniprot |
| CBLB | uniprot |
| TRAILR1 | uniprot |
| BTK | uniprot |
| KIT | uniprot |
| KITLG | uniprot |
| KIT | uniprot |
| KITLG | uniprot |
| MAP2K1 | uniprot |
| STAT3 | uniprot |
| MPDZ | uniprot |
| DOK1 | uniprot |
| p85 complex | |
| Molecular association | |
| Phosphorylation | chemical |
| Activation | chemical |
| Inhibition | chemical |
| Autophosphorlation | |
| Dephosphorylation | chemical |
| Plasma Membrane | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| CY->PM | |
| Accession Number: NetPath_6; cellmap:6 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| (Protein-protein interaction) | |
| D | |
| PM | |
| CY | |
| NU | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| Translocation | |
| Desumoylation |
| CS | ||
| ACO2 | uniprot | |
| IDH2 | uniprot | |
| SDHB | uniprot | |
| FH | ||
| MDH2 | uniprot | |
| MDH1 | uniprot | |
| PDHA1 | uniprot | |
| PDHA2 | uniprot | |
| PDK1 | uniprot | |
| PDK2 | uniprot | |
| PDK3 | uniprot | |
| PDK4 | uniprot | |
| PPM2C | uniprot | |
| PDP2 | uniprot | |
| DLAT | uniprot | |
| PDHB | uniprot | |
| OGDH | uniprot | |
| SDHC | uniprot | |
| SDHD | uniprot | |
| DLD | uniprot | |
| DLD | uniprot | |
| SUCLG2 | uniprot | |
| SUCLG1 | uniprot | |
| SUCLA2 | uniprot | |
| PDHX | uniprot | |
| DLST | uniprot | |
| IDH3A | uniprot | |
| IDH3B | uniprot | |
| PC | ||
| SDHA | uniprot | |
| IDH3G | uniprot | |
| Pyruvate | hmdbid:HMDB00243 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Succinate | hmdbid:HMDB00254 | |
| Malate | hmdbid:HMDB03256 | |
| alpha-Ketogluterate | chemical | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Fumarate | hmdbid:HMDB00134 | |
| Malate | hmdbid:HMDB03256 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Isocitrate | hmdbid:HMDB00193 | |
| Fatty Acid Synthesis | ||
| Glycolysis | ||
| Gluconeogenesis | chemical | |
| Degradation of Fatty Acids | ||
| Containing an Odd Number of Carbons | ||
| Electron Transport Chain | ||
| Degradation of Fatty Acids | ||
| Containing an Even Number of Carbons | ||
| Citrate | hmdbid:HMDB00094 | |
| Succinyl-CoA | hmdbid:HMDB01022 | |
| Mitochondrion | ||
| Cytosol |
| SIPA1 | uniprot |
| PLCB3 | uniprot |
| RASA3 | uniprot |
| HRAS | uniprot |
| NRAS | uniprot |
| RRAS | uniprot |
| KRAS | uniprot |
| RAF1 | uniprot |
| ARAF | uniprot |
| BRAF | uniprot |
| MAP3K1 | uniprot |
| MAP3K2 | uniprot |
| MAP3K3 | uniprot |
| MAP2K1 | uniprot |
| MAP2K2 | uniprot |
| MAPK3 | uniprot |
| MAPK1 | uniprot |
| MBP | uniprot |
| MAP2 | uniprot |
| ELK1 | uniprot |
| MAP2K7 | uniprot |
| MAP2K4 | uniprot |
| MAPK10 | uniprot |
| MAP2K6 | uniprot |
| MAPK14 | uniprot |
| MAP2K3 | uniprot |
| MAP2K4 | uniprot |
| JUN | uniprot |
| MAP3K12 | uniprot |
| MAPK12 | uniprot |
| RapGAPII | chemical |
| GDP | hmdbid:HMDB01201 |
| Rap1GAP | uniprot |
| Activated | |
| GTP | hmdbid:HMDB01273 |
| G | |
| i | |
| G | |
| q | |
| and G | |
| g | |
| b | |
| G | |
| Stress Activated Pathways | |
| p38 MAPK Pathway | |
| Growth and Mitogenesis | |
| Apoptosis | |
| Nucleus | CHEBI:33252 |
| TMEM37 | uniprot | |
| PRKCD | uniprot | |
| IL1R2 | uniprot | |
| IL1R1 | uniprot | |
| FAS | uniprot | |
| ACVR1C | uniprot | |
| ACVR1B | uniprot | |
| TGFBR1 | uniprot | |
| TGFBR2 | uniprot | |
| CD14 | uniprot | |
| TNF | uniprot | |
| GADD45A | uniprot | |
| MAP4K3 | uniprot | |
| MAP3K12 | uniprot | |
| PPM1B | uniprot | |
| MAP2K5 | uniprot | |
| MAPK7 | uniprot | |
| MAP2K1 | uniprot | |
| MAP2K2 | uniprot | |
| MAPK1 | uniprot | |
| MAPK3 | uniprot | |
| MAPK4 | uniprot | |
| PPP5C | uniprot | |
| mkk3 | uniprot | |
| MAP2K6 | uniprot | |
| elk-1 | chemical | |
| Sap1a | chemical | |
| PDGFB | uniprot | |
| RASA2 | uniprot | |
| MAP2K1IP1 | uniprot | |
| MAPK6 | uniprot | |
| nfat2/4 | ||
| sap1a | chemical | |
| MAPKAPK5 | uniprot | |
| msk1/2 | ||
| NLK | uniprot | |
| TAOK2 | uniprot | |
| SITPEC | ||
| MAP3K7IP2 | uniprot | |
| MAP3K7IP1 | uniprot | |
| TRAF6 | uniprot | |
| MAP3K6 | uniprot | |
| GCK | uniprot | |
| MAP3K13 | uniprot | |
| ZAK | uniprot | |
| MAP3K11 | uniprot | |
| MAP4K1 | uniprot | |
| MAP4K4 | uniprot | |
| MAP2K7 | uniprot | |
| MAP2K4 | uniprot | |
| NGFB | uniprot | |
| BDNF | uniprot | |
| NTF5 | uniprot | |
| NTRK1 | uniprot | |
| EGF | uniprot | |
| FGF4 | uniprot | |
| fgfr | ||
| EGFR | uniprot | |
| PDGFRB | uniprot | |
| GNA12 | uniprot | |
| GRB2 | uniprot | |
| SOS2 | uniprot | |
| MRAS | uniprot | |
| NRAS | uniprot | |
| KRAS | uniprot | |
| RASGRP1 | ||
| RASGRP4 | ||
| RASGRF2 | ||
| PRKCG | uniprot | |
| PRKCB1 | uniprot | |
| PRKCZ | uniprot | |
| PRKCH | uniprot | |
| PRKCD | uniprot | |
| PRKACA | uniprot | |
| RAP1B | uniprot | |
| RAP1A | uniprot | |
| BRAF | uniprot | |
| RAF1 | uniprot | |
| MOS | uniprot | |
| NF1 | uniprot | |
| RASA1 | uniprot | |
| PTPRR | uniprot | |
| PTPN7 | uniprot | |
| PTPN5 | uniprot | |
| MAP3K14 | uniprot | |
| IKBKG | uniprot | |
| IKBKB | enzyme | uniprot |
| DUSP1 | uniprot | |
| DUSP6 | uniprot | |
| DUSP5 | uniprot | |
| DUSP7 | uniprot | |
| DUSP4 | uniprot | |
| DUSP10 | uniprot | |
| STMN1 | uniprot | |
| MAPT | uniprot | |
| NFKB1 | uniprot | |
| mnk1/2 | ||
| PLA2G5 | uniprot | |
| PLA2G10 | uniprot | |
| RPS6KA3 | uniprot | |
| ATF4 | uniprot | |
| MYC | uniprot | |
| FOS | uniprot | |
| SRF | uniprot | |
| PPP3CC | uniprot | |
| PPP3CA | uniprot | |
| PPP3CB | uniprot | |
| PPP3R1 | uniprot | |
| PPP3R2 | uniprot | |
| HSPA8 | uniprot | |
| HSPA1A | uniprot | |
| JUN | uniprot | |
| JUND | uniprot | |
| ATF2 | uniprot | |
| ELK1 | uniprot | |
| TP53 | uniprot | |
| HSPA5 | uniprot | |
| MAPK8IP3 | uniprot | |
| CRK | uniprot | |
| CRKL | uniprot | |
| FLNA | uniprot | |
| ARRB1 | uniprot | |
| ARRB2 | uniprot | |
| MAPK8 | uniprot | |
| MAPK10 | uniprot | |
| MAPK9 | uniprot | |
| MAPK8IP1 | uniprot | |
| PTPN7 | uniprot | |
| PTPN5 | uniprot | |
| PTPRR | uniprot | |
| PPM1A | uniprot | |
| AKT1 | uniprot | |
| AKT2 | uniprot | |
| AKT3 | uniprot | |
| STK3 | uniprot | |
| MINK1 | uniprot | |
| PAK2 | uniprot | |
| PAK1 | uniprot | |
| MAP3K1 | uniprot | |
| MEKK2/3 | ||
| MAP3K8 | uniprot | |
| RAC2 | uniprot | |
| RAC1 | uniprot | |
| CDC42 | uniprot | |
| CASP6 | uniprot | |
| CASP2 | uniprot | |
| CASP8 | uniprot | |
| CASP7 | uniprot | |
| CASP9 | uniprot | |
| CASP3 | uniprot | |
| CASP1 | uniprot | |
| TRAF2 | uniprot | |
| MAPK13 | uniprot | |
| MAPK12 | uniprot | |
| DDIT3 | uniprot | |
| MAX | uniprot | |
| MEF2C | uniprot | |
| HSPB2 | uniprot | |
| HSPB1 | uniprot | |
| ATF4 | uniprot | |
| CDC25B | uniprot | |
| NR4A1 | uniprot | |
| MAPKAPK2 | uniprot | |
| MAPK14 | uniprot | |
| TAOK1 | uniprot | |
| MAP3K4 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K5 | uniprot | |
| DAXX | uniprot | |
| TGFB2 | uniprot | |
| TGFB1 | uniprot | |
| TGFB3 | uniprot | |
| FASLG | uniprot | |
| IL1B | uniprot | |
| IL1A | uniprot | |
| Classical MAP kinase Pathway | ||
| Ca2+ | CHEBI:29108 | |
| DAG | uniprot | |
| LPS | CHEBI:16412 | |
| DNA damage | ||
| JNK & p38 MAP kinase pathway | ||
| Serum, cytotoxic drugs, irradiation, | ||
| heatshock, reactive oxy species | ||
| LPS and other stress | ||
| Integrin-mediated | ||
| cell adhesion | ||
| cAMP | hmdbid:HMDB00058 | |
| IP3 | ||
| Heteromeric G-protein | ||
| Phosphatidylinositol | chemical | |
| signaling system | ||
| MAPKKKK | ||
| ERK5 pathway | ||
| Serum, EGF, | ||
| reactive oxygen species, | ||
| or Srk tyrosinkinase | ||
| downstream | ||
| PTP | uniprot | |
| MKP | ||
| p38 | uniprot | |
| Proliferation, inflammation, anti-apoptosis | ||
| DNA | CHEBI:16991 | |
| DNA | CHEBI:16991 | |
| Proliferation, | ||
| differentiation | ||
| JNK | enzyme | uniprot |
| PTP | uniprot | |
| MAPKKK | enzyme | uniprot |
| MAPKK | enzyme | uniprot |
| MAPK | enzyme | uniprot |
| Transcription factors | ||
| DNA | CHEBI:16991 | |
| Alzheimer’s disease | ||
| Wnt signaling | ||
| DNA | CHEBI:16991 | |
| Apoptosis | ||
| Proliferation, differentiation, | ||
| inflammation | ||
| DNA | CHEBI:16991 | |
| Proliferation, differentiation | ||
| Cell | ||
| Cycle | ||
| pathway |
| MMP2 | uniprot |
| MMP9 | uniprot |
| MMP7 | uniprot |
| MMP12 | uniprot |
| MMP20 | uniprot |
| MMP10 | uniprot |
| MMP3 | uniprot |
| MMP11 | uniprot |
| MMP19 | uniprot |
| MMP14 | uniprot |
| MMP15 | uniprot |
| MMP16 | uniprot |
| MMP17 | uniprot |
| MMP24 | uniprot |
| TIMP2 | uniprot |
| TIMP3 | uniprot |
| TIMP4 | uniprot |
| BSG | uniprot |
| TNF | uniprot |
| MMP26 | uniprot |
| MMP28 | uniprot |
| MMP23A | uniprot |
| MMP25 | uniprot |
| MMP27 | |
| TCF20 | uniprot |
| MMP21 | uniprot |
| MMP1 | uniprot |
| MMP8 | uniprot |
| MMP13 | uniprot |
| TIMP1 | uniprot |
| MMP23B | uniprot |
| Gelatinases | |
| Collagenases | |
| Stromelysins | chemical |
| Membrane-type MMPs | |
| Matrilysin | enzyme |
| Inhibitors | |
| Enamelysin | uniprot |
| Other | |
| Potential Inducers of Transcription | |
| Metalloelastase | enzyme |
| Based on Vu & Werb (2000) | |
| Matrix metalloproteinases: effectors of | |
| development and normal physiology. | |
| Genes Dev 14:2123-2133 |
| ACADL | uniprot | |
| CPT2 | uniprot | |
| ACADM | uniprot | |
| ACSL2 | ||
| PECR | uniprot | |
| DCI | uniprot | |
| SCP2 | uniprot | |
| EHHADH | uniprot | |
| ACADS | uniprot | |
| ACADVL | uniprot | |
| CPT1A | uniprot | |
| HADHSC | uniprot | |
| HADHA | uniprot | |
| ACSL3 | uniprot | |
| ACSL4 | uniprot | |
| SLC25A20 | uniprot | |
| ACSL1 | uniprot | |
| Long chain Acyl-CoA | ||
| Long chain Acyl-CoA | ||
| trans- | chemical | |
| 3-Ketoacyl-CoA | chemical | |
| saturated | ||
| unsaturated | ||
| mitochondrial matrix | ||
| cytosol | ||
| -Enoyl-CoA | chemical | |
| Acyl-CoA (n-2) | ||
| 2,4 Dienoyl-CoA | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| D | ||
| 2 | ||
| 3-L-Hydroxyacyl-CoA | chemical | |
| Long chain acyl-carnitine | ||
| Long chain acyl-carnitine | ||
| cis- | chemical | |
| D- | ||
| -Enoyl-CoA | chemical | |
| 3 | ||
| Acyl-CoA dehydrogenases: | ||
| Long Chain Fatty Acid |
| DRD1 | uniprot |
| DRD2 | uniprot |
| DRD3 | uniprot |
| DRD5 | uniprot |
| HTR1A | uniprot |
| HTR1B | uniprot |
| HTR1D | uniprot |
| HTR1E | uniprot |
| HTR1F | uniprot |
| HTR2A | uniprot |
| HTR2B | uniprot |
| HTR2C | uniprot |
| HTR4 | uniprot |
| HTR5A | uniprot |
| HTR6 | uniprot |
| HTR7 | uniprot |
| ADRA1A | uniprot |
| ADRA1B | uniprot |
| ADRA1D | uniprot |
| ADRA2A | uniprot |
| ADRB1 | uniprot |
| ADRB2 | uniprot |
| ADRB3 | uniprot |
| HRH1 | uniprot |
| HRH2 | uniprot |
| CHRM1 | uniprot |
| CHRM2 | uniprot |
| CHRM3 | uniprot |
| CHRM5 | uniprot |
| DRD4 | uniprot |
| HTR5B | |
| ADRA2C | uniprot |
| ADRA2B | uniprot |
| CHRM4 | uniprot |
| Dopamine | hmdbid:HMDB00073 |
| Adrenergic | |
| Serotonin | hmdbid:HMDB00259 |
| Gi/Go Pathway | |
| Gq/G11 Pathway | |
| Gs Pathway | |
| Gs Pathway | |
| Muscarinic | |
| Histamine | hmdbid:HMDB00870 |
| Acetylcholine Receptors | |
| Receptors | |
| Receptors | |
| Receptors | |
| Receptors |
| HNRPA1 | uniprot | |
| HNRPA2B1 | uniprot | |
| HNRPAB | uniprot | |
| HNRPC | uniprot | |
| HNRPK | uniprot | |
| HNRPL | uniprot | |
| FUSIP1 | uniprot | |
| SNRPD1 | uniprot | |
| SNRPD2 | uniprot | |
| SNRPE | uniprot | |
| SNRPF | uniprot | |
| SNRPG | uniprot | |
| CSTF1 | uniprot | |
| CSTF2 | uniprot | |
| CPSF3 | uniprot | |
| CPSF1 | uniprot | |
| CPSF2 | uniprot | |
| CSTF2T | uniprot | |
| PABPN1 | uniprot | |
| SFRS9 | uniprot | |
| LSM2 | uniprot | |
| SFRS1 | uniprot | |
| SFRS2 | uniprot | |
| SFRS3 | uniprot | |
| SFRS5 | uniprot | |
| SRRM1 | uniprot | |
| CLK3 | uniprot | |
| CLK4 | uniprot | |
| U2AF2 | uniprot | |
| CDC40 | uniprot | |
| SNRPN | uniprot | |
| SFRS7 | uniprot | |
| SFRS6 | uniprot | |
| SFRS10 | uniprot | |
| POLR2A | uniprot | |
| SUPT5H | uniprot | |
| RNMT | uniprot | |
| RNGTT | uniprot | |
| NCBP1 | uniprot | |
| NCBP2 | uniprot | |
| METTL3 | uniprot | |
| HNRPD | uniprot | |
| HNRPH1 | uniprot | |
| HNRPH2 | uniprot | |
| HNRPR | uniprot | |
| HNRPM | uniprot | |
| PTBP1 | uniprot | |
| Rnu6 | ||
| SNRP70 | uniprot | |
| SNRPA | uniprot | |
| SNRPB | uniprot | |
| SMC1L1 | uniprot | |
| CD2BP2 | uniprot | |
| NSEP1 | uniprot | |
| DHX9 | uniprot | |
| SNRPD3 | uniprot | |
| SFRS14 | uniprot | |
| TMP21 | uniprot | |
| SFRS12 | uniprot | |
| SFRS16 | uniprot | |
| FUS | uniprot | |
| SF4 | uniprot | |
| RBM5 | uniprot | |
| NUDT21 | uniprot | |
| CPSF4 | uniprot | |
| C20orf14 | uniprot | |
| WDR57 | uniprot | |
| TXNL4A | uniprot | |
| SF3B5 | uniprot | |
| SFRS4 | uniprot | |
| SNRPB2 | uniprot | |
| SF3A3 | uniprot | |
| SNRPA1 | uniprot | |
| SF3A1 | uniprot | |
| SF3A2 | uniprot | |
| SF3B1 | uniprot | |
| SF3B2 | uniprot | |
| DHX38 | uniprot | |
| CDC40 | uniprot | |
| DNAJC8 | uniprot | |
| PRPF8 | uniprot | |
| PHF5A | uniprot | |
| PRPF4 | uniprot | |
| PRPF4 | uniprot | |
| LSM2 | uniprot | |
| PRPF8 | uniprot | |
| CSTF3 | uniprot | |
| HEAB | uniprot | |
| PAPOLA | uniprot | |
| DDX1 | uniprot | |
| HRMT1L1 | uniprot | |
| HRMT1L2 | uniprot | |
| PCBP2 | uniprot | |
| DICER1 | uniprot | |
| DDX20 | uniprot | |
| DHX15 | uniprot | |
| DHX8 | uniprot | |
| PRPF4B | uniprot | |
| NXF1 | uniprot | |
| DHX16 | uniprot | |
| CUGBP1 | uniprot | |
| RNPC2 | uniprot | |
| BRUNOL4 | ||
| NONO | uniprot | |
| XRN2 | uniprot | |
| SPOP | uniprot | |
| CUGBP2 | ||
| PTBP2 | uniprot | |
| PRPF3 | uniprot | |
| FNBP3 | uniprot | |
| RBM17 | uniprot | |
| U2AF1 | uniprot | |
| SRPK1 | uniprot | |
| SRPK2 | uniprot | |
| PPM1G | uniprot | |
| RNPS1 | uniprot | |
| SRP54 | uniprot | |
| HNRPU | uniprot | |
| SFRS8 | uniprot | |
| SFPQ | uniprot | |
| PSKH1 | uniprot | |
| PRPF18 | uniprot | |
| HNRPA3P1 | ||
| RBMX | uniprot | |
| U1 snRNA | ||
| RNU2 | uniprot | |
| SF3B4 | uniprot | |
| SF3B3 | uniprot | |
| CLK1 | uniprot | |
| CLK2 | uniprot | |
| LSM7 | uniprot | |
| SNRPN | uniprot | |
| FUSIP1 | uniprot | |
| U5-116KD | ||
| U5 snRNA | ||
| SSFA1 | ||
| SSFA1 | ||
| SSFA1 | ||
| U4 snRNA | ||
| 5 G cap | ||
| 3 | ||
| 5 | ||
| 3 | ||
| 5 | ||
| 3 | ||
| 5 | ||
| Polr2a | uniprot | |
| Spt5 | uniprot | |
| Rnmt (methyltransferase) | ||
| GMP | hmdbid:HMDB01397 | uniprot |
| mRNA Capping | ||
| Processing of Intron-Containing Pre-mRNA | ||
| iPo | ||
| Cap Binding | ||
| Methylation of mRNA | ||
| heterogeneous nuclear ribonucleoproteins | ||
| Formation of pre-mRNPs | ||
| Internal methylation of mRNA | ||
| mRNA splicing (major pathway) | ||
| pre-mRNA | ||
| Primary RNA transcript | ||
| hnRNPs | ||
| Formation of the Spliceosomal E complex | ||
| snRNP Sm core complex | ||
| U1 snRNP | ||
| 3 | ||
| exon 1 | ||
| exon 2 | ||
| intron | ||
| GU | ||
| A | ||
| YYYY | ||
| AG | ||
| 5 | ||
| SR-binding sites | ||
| SR-binding sites | ||
| U1 snRNP | ||
| U2AF | ||
| 65 | ||
| 35 | ||
| RNA helicase A | ||
| U2AF | ||
| Serine/Argenine Rich Proteins(SR) | ||
| mRNA capping | ||
| Internal methylation of mRNA | ||
| Formation of pre-mRNPs | ||
| SR-proteins | ||
| Regulation of | ||
| Alternative Splicing | ||
| Additional Factors | ||
| Regulators | ||
| splicing factor SF3A | ||
| splicing factor SF3B | ||
| U2 snRNPs | ||
| SF3b14b | uniprot | |
| SR-proteins | ||
| Additional Factors | ||
| RNA helicase | ||
| U2 snRNP | ||
| snRNP Sm core complex | ||
| Formation of the Spliceosomal A complex | ||
| Formation of the Spliceosomal E complex | ||
| Formation of the Spliceosomal A complex | ||
| U2 snRNP | ||
| 3 | ||
| A | ||
| YYYY | ||
| AG | ||
| 5 | ||
| exon 1 | ||
| exon 2 | ||
| U4/U6 | ||
| U5 | ||
| Formation of the Spliceosomal B complex | ||
| U4 snRNP | ||
| U6 snRNP | ||
| U5 snRNP | ||
| snRNP Sm core complex | ||
| U4:U5:U6 tri-snRNP complex | ||
| YYYY | ||
| AG | ||
| 5 | ||
| exon 1 | ||
| exon 2 | ||
| A | ||
| 3 | ||
| U5 | ||
| Note: New participating members shown at each step | ||
| UG | ||
| U6 | ||
| U2 | ||
| U4 | ||
| U1 | ||
| Formation of the Spliceosomal C complex | ||
| Poly(A)-binding protein II | uniprot | |
| CF II | ||
| Poly(A) polymerase alpha | uniprot | |
| CF I | chemical | |
| YYYY | ||
| AG | ||
| 5 | ||
| exon 2 | ||
| A | ||
| 3 | ||
| UG | ||
| exon 1 | ||
| YYYY | ||
| AG | ||
| 5 | ||
| A | ||
| 3 | ||
| exon 1 | ||
| exon 2 | ||
| YYYY | ||
| AG | ||
| A | ||
| 5 | ||
| exon 2 | ||
| CstF | ||
| CFI | enzyme | uniprot |
| CF II | ||
| Poly(A)pb II | ||
| Poly(A) pol | ||
| 5 | ||
| 3 | ||
| AAAAAAA | ||
| Pi | ||
| P- | ||
| degraded | ||
| SR protein kinases | ||
| Additional SR proteins | ||
| Putative Alternative Splicing | ||
| Accessory Proteins | ||
| mRNA splice site selection | ||
| hnRNP regulators | ||
| RNAi pathway | ||
| 3 | ||
| exon 1 | ||
| Formation of the Spliceosomal B complex | ||
| Formation of the active Spliceosomal C complex | ||
| Lariat Formation and 5’-Splice Site Cleavage | ||
| Cleavage at the 3’-Splice-Site and Exon Ligation | ||
| (1) | ||
| (2) | ||
| (2a) | ||
| (2b) | ||
| (2c) | ||
| (3) | ||
| mRNA 3’-end processing | ||
| Cleavage of mRNA at the 3’-end | ||
| mRNA polyadenylation | ||
| CPSF | ||
| CstF | ||
| right click on blue text for detailed information | ||
| 5 | ||
| 3 | ||
| AAUAAA | ||
| CA | ||
| ATP | hmdbid:HMDB00538 | |
| CPSF | ||
| splicesome associated helicases | ||
| Misc. | ||
| Rngtt (capping enzyme) | ||
| SR-kinases | ||
| Kinases Phosphorylating RS domains? | ||
| P | ||
| SR-phosphatases | ||
| SR-proteins | ||
| SR protein phosphatases | ||
| SR-repressor proteins | ||
| Additional Factors |
| RBPSUHL | uniprot | |
| PTCRA | ||
| HDAC2 | uniprot | |
| CTBP1 | uniprot | |
| CTBP2 | uniprot | |
| CREBBP | uniprot | |
| GCN5L2 | uniprot | |
| PCAF | uniprot | |
| DLL1 | uniprot | |
| DLL3 | uniprot | |
| DLL4 | uniprot | |
| JAG1 | uniprot | |
| JAG2 | uniprot | |
| LFNG | uniprot | |
| MFNG | uniprot | |
| RFNG | uniprot | |
| NOTCH2 | uniprot | |
| NOTCH3 | uniprot | |
| NOTCH4 | uniprot | |
| ADAM17 | uniprot | |
| APH1A | uniprot | |
| APH1B | uniprot | |
| TNF | uniprot | |
| PSEN1 | uniprot | |
| PSEN2 | uniprot | |
| NCSTN | uniprot | |
| DVL1 | uniprot | |
| DVL2 | uniprot | |
| DVL3 | uniprot | |
| NUMB | uniprot | |
| NUMBL | uniprot | |
| DTX1 | uniprot | |
| DTX2 | uniprot | |
| DTX3 | uniprot | |
| DTX4 | ||
| DTX31 | ||
| RBP-J | uniprot | |
| MAML1 | uniprot | |
| NCOR2 | uniprot | |
| HES1 | uniprot | |
| HES5 | ||
| NOTCH1 | uniprot | |
| MAML3 | uniprot | |
| LOC330129 | ||
| HDAC1 | uniprot | |
| CIR | hmdbid:HMDB00904 | uniprot |
| SKIP | uniprot | |
| NICD | ||
| co-repressor complex | ||
| DNA | CHEBI:16991 | |
| Notch Intracellular Domain | ||
| MAPK signaling pathway | ||
| gene expression | ||
| S2 | ||
| S3 | ||
| Ras/Map |
| THRA | uniprot |
| THRB | uniprot |
| THRB | uniprot |
| RARA | uniprot |
| RARB | uniprot |
| RARG | uniprot |
| RARG | uniprot |
| PPARA | uniprot |
| PPARD | uniprot |
| PPARG | uniprot |
| PPARG | uniprot |
| NR1D2 | uniprot |
| NR0B1 | uniprot |
| ROR1 | uniprot |
| RORA | uniprot |
| RORC | uniprot |
| NR1H2 | uniprot |
| NR1H3 | uniprot |
| VDR | uniprot |
| HNF4A | uniprot |
| RXRA | uniprot |
| RXRB | uniprot |
| RXRG | uniprot |
| NR2C2 | uniprot |
| NR2F1 | uniprot |
| NR2F2 | uniprot |
| NR2F6 | uniprot |
| NR2E1 | uniprot |
| ESR1 | uniprot |
| ESR2 | uniprot |
| ESRRA | uniprot |
| ESRRB | uniprot |
| NR3C1 | uniprot |
| PGR | uniprot |
| AR | |
| NR4A1 | uniprot |
| NR4A2 | uniprot |
| NR5A1 | uniprot |
| NR5A2 | uniprot |
| NR1I2 | uniprot |
| NR1I3 | uniprot |
| Thyroid Receptor | |
| Peroxisome Proliferator | |
| Nuclear Receptor ROR | |
| Oxysterols Receptor | |
| Vitamin D3 Receptor | uniprot |
| Hepatocyte Nuclear Factor | |
| Retinoic Acid Receptor RXR | |
| Orphan Nuclear Receptor | |
| Nuclear receptor TLX | uniprot |
| Coup Transcription Factor | |
| Estrogen Receptor | uniprot |
| Steroid Hormone Receptor | |
| Glucocorticoid Receptor | uniprot |
| Progesterone Receptor | uniprot |
| Androgen Receptor | uniprot |
| NR5 SUPERFAMILY | |
| Steroidogenic Receptor | |
| Orphan Receptor | |
| NR0 SUPERFAMILY | |
| NR1 SUPERFAMILY | |
| NR2 SUPERFAMILY | |
| NR3 SUPERFAMILY | |
| NR4 SUPERFAMILY | |
| Orphan Receptor | |
| Orphan Nuclear | |
| Activated Receptor | |
| Receptor | |
| Retinoic Acid Receptor |
| CYP7A1 | uniprot | |
| CYP7A1 | uniprot | |
| CYP7A1 | uniprot | |
| CYP4A11 | uniprot | |
| PPARG | uniprot | |
| PPARA | uniprot | |
| PPARD | uniprot | |
| ABCD3 | uniprot | |
| ABCD2 | uniprot | |
| ABCA1 | uniprot | |
| ABCA1 | uniprot | |
| ABCA1 | uniprot | |
| ABCB4 | uniprot | |
| ABCB11 | uniprot | |
| ABCB1a | ||
| ABCB1 | uniprot | |
| ABCC2 | uniprot | |
| ABCC3 | uniprot | |
| ABCG1 | uniprot | |
| ABCG5 | uniprot | |
| abcg6 | ||
| NR1H4 | uniprot | |
| NR1H3 | uniprot | |
| CYP8B1 | uniprot | |
| NR1I2 | uniprot | |
| NR1I3 | uniprot | |
| CYP4B1 | uniprot | |
| RARA | uniprot | |
| RARG | uniprot | |
| CYP3A4 | uniprot | |
| VDR | uniprot | |
| CYP3A4 | uniprot | |
| CYP26A1 | uniprot | |
| RARB | uniprot | |
| CYP2E1 | uniprot | |
| CYP2C9 | uniprot | |
| CYP2C9 | uniprot | |
| CYP2B6 | uniprot | |
| CYP2B6 | uniprot | |
| CYP1A2 | uniprot | |
| CYP24A1 | uniprot | |
| CYP2C9 | uniprot | |
| CYP3A4 | uniprot | |
| CYP27B1 | uniprot | |
| Right click for comments | ||
| Acetyl CoA | hmdbid:HMDB01206 | uniprot |
| Isoprenoids | CHEBI:24913 | |
| Lanosterol | hmdbid:HMDB01251 | |
| 7-DehydroCholesterol | hmdbid:HMDB00032 | |
| Cholesterol | hmdbid:HMDB00067 | |
| Oxysterol | chemical | |
| Bile Acids | CHEBI:3098 | |
| 1,25-Dihydroxy-Vitamins D3 | ||
| Fatty Acids | CHEBI:35366 | |
| DIET | ||
| Xenobiotics | CHEBI:35703 | |
| DIET | ||
| Retinoic Ac | ||
| Steroids | CHEBI:35341 | |
| Gene expression |
| ADORA1 | uniprot |
| ADORA2A | uniprot |
| ADORA2B | uniprot |
| ADORA3 | uniprot |
| P2RY1 | uniprot |
| P2RY2 | uniprot |
| P2RY5 | uniprot |
| P2RY6 | uniprot |
| LTB4R | uniprot |
| GPR23 | uniprot |
| P2RY4 | uniprot |
| Adenosine | hmdbid:HMDB00050 |
| Adenine | hmdbid:HMDB00034 |
| Gi/Go Pathway | |
| Gs Pathway | |
| Gq/G11 Pathway |
| PRPS1 | uniprot | |
| PRPS2 | uniprot | |
| DHFR | uniprot | |
| MTHFD2 | uniprot | |
| ADSL | uniprot | |
| IMPDH1 | uniprot | |
| ADSS | uniprot | |
| POLA | uniprot | |
| POLB | uniprot | |
| POLG | uniprot | |
| POLD1 | uniprot | |
| NME2 | uniprot | |
| RRM1 | uniprot | |
| SAT | uniprot | |
| SRM | uniprot | |
| OAZ1 | uniprot | |
| HPRT1 | uniprot | |
| Ribose | hmdbid:HMDB00283 | |
| PRPP | hmdbid:HMDB00280 | uniprot |
| SAICAR | hmdbid:HMDB00797 | |
| AICAR | hmdbid:HMDB03192 | |
| IMP | hmdbid:HMDB00175 | uniprot |
| DNA | CHEBI:16991 | |
| DNA Synthesis | ||
| dNTPs | ||
| dNTPs | ||
| GMP | hmdbid:HMDB01397 | uniprot |
| dNTPs | ||
| Xanthine | hmdbid:HMDB00292 | |
| GMP | hmdbid:HMDB01397 | uniprot |
| Guanine | hmdbid:HMDB00132 | |
| Uric Acid | hmdbid:HMDB00289 | |
| Adenylosuccinate | hmdbid:HMDB00536 | |
| AMP | hmdbid:HMDB00045 | uniprot |
| Hypoxanthine | hmdbid:HMDB00157 | |
| Spermine | hmdbid:HMDB01256 | |
| Adenine | hmdbid:HMDB00034 | |
| Spermidine | hmdbid:HMDB01257 | |
| Putrescine | hmdbid:HMDB01414 | |
| Ornithine | hmdbid:HMDB03374 | |
| Polyamine | chemical | |
| Synthesis | ||
| Monophasphate | chemical |
| BMPR1B | uniprot |
| PRLR | uniprot |
| FSHR | uniprot |
| LHCGR | uniprot |
| ZP3 | uniprot |
| ZP3 | uniprot |
| Fig-alpha | |
| DMC1 | uniprot |
| ATM | uniprot |
| MLH1 | uniprot |
| MSH5 | uniprot |
| GDF9 | uniprot |
| ZP2 | uniprot |
| SMPD1 | uniprot |
| DAZL | uniprot |
| GJA4 | uniprot |
| GJA4 | uniprot |
| INHA | uniprot |
| SMAD3 | uniprot |
| PGR | uniprot |
| ESR2 | uniprot |
| VDR | uniprot |
| NR5A1 | uniprot |
| TF2D | uniprot |
| NCOR1 | uniprot |
| NRIP1 | uniprot |
| EGR1 | uniprot |
| CEBPB | uniprot |
| PTGER2 | uniprot |
| CDKN1B | uniprot |
| CCND2 | uniprot |
| CDK4 | uniprot |
| SMPD1 | uniprot |
| CYP19A1 | uniprot |
| SYNE2 | uniprot |
| Granulosa Cell | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Oocyte | |
| Nucleus | CHEBI:33252 |
| Ooplasm |
| MAOA | uniprot |
| NFIX | uniprot |
| NFKB1 | uniprot |
| SP1 | uniprot |
| HMOX1 | uniprot |
| GPX1 | uniprot |
| GPX3 | uniprot |
| NQO1 | uniprot |
| UGT1A6 | uniprot |
| CAT | uniprot |
| TXN2 | uniprot |
| TXNRD1 | uniprot |
| TXNRD2 | uniprot |
| GCLC | uniprot |
| GSR | uniprot |
| MT1X | uniprot |
| GSTT2 | uniprot |
| MGST1 | uniprot |
| CYP1A1 | uniprot |
| CYBA | uniprot |
| FOS | uniprot |
| JUNB | uniprot |
| SOD2 | uniprot |
| SOD1 | uniprot |
| SOD3 | uniprot |
| MAPK14 | uniprot |
| MAPK10 | uniprot |
| Nrf2 | uniprot |
| XDH | uniprot |
| antioxidant genes | |
| Induction of | |
| Inhibition of oxidases | |
| TF inhibition | |
| repression | |
| TF activation | |
| Immediate-early | |
| gene induction | |
| Reactive Oxygen Species | CHEBI:26523 |
| Adaptive response | |
| Repression of ROS- | |
| producing systems | |
| Activation | chemical |
| Stress-regulated MAP kinase |
| MAPK14 | uniprot |
| MAPK14 | uniprot |
| MAP2K6 | uniprot |
| MAP3K9 | uniprot |
| MAP3K7 | uniprot |
| MAP3K5 | uniprot |
| MKNK1 | uniprot |
| MAPKAPK5 | uniprot |
| HSPB1 | uniprot |
| MAPKAPK2 | uniprot |
| MAPKAPK2 | uniprot |
| ATF2 | uniprot |
| RPS6KA5 | uniprot |
| MEF2D | uniprot |
| DDIT3 | uniprot |
| ELK1 | uniprot |
| STAT1 | uniprot |
| MAX | uniprot |
| MYC | uniprot |
| HMGN1 | uniprot |
| CREB1 | uniprot |
| PLA2G4A | uniprot |
| MAP2K4 | uniprot |
| MAP3K1 | uniprot |
| RAC1 | uniprot |
| CDC42 | uniprot |
| HRAS | uniprot |
| TGFBR1 | uniprot |
| TGFB2 | uniprot |
| TRADD | uniprot |
| TRAF2 | uniprot |
| DAXX | uniprot |
| RIPK1 | uniprot |
| SHC1 | uniprot |
| GRB2 | uniprot |
| RASGRF1 | uniprot |
| Apoptosis | |
| Translation | |
| ? | |
| ? | |
| ? | |
| Stress: Osmotic shock | |
| g-radiation, Anisomycin | |
| Right click for comments | |
| FASL, Inflammatory | |
| Cytokines, UV, etc. | |
| Growth Factors, UV | |
| Trophic Factors, etc. | |
| DNA transcription | |
| Cytokines Production, | |
| Apoptosis, etc. | |
| ? | |
| ? |
| G6PD | enzyme | uniprot |
| PGLS | uniprot | |
| PGD | uniprot | |
| RPIA | uniprot | |
| TKT | uniprot | |
| TKT | uniprot | |
| TALDO1 | uniprot | |
| RPE | uniprot | |
| Glucose-6-Phosphate | hmdbid:HMDB01401 | |
| 6-Phosphoglucono-delta-lactone | hmdbid:HMDB01127 | |
| 6-Phosphogluconate | hmdbid:HMDB01316 | |
| Ribulose-5-Phosphate | hmdbid:HMDB00618 | |
| Ribose-5-Phosphate | hmdbid:HMDB01548 | |
| (Hexose Monophosphosphate Shunt | ||
| or Phosphogluconate Pathway) | ||
| Fructose-6-Phosphate + Erythose-4-Phosphate | ||
| Fructose-6-Phosphate | hmdbid:HMDB00124 | |
| Sedoheptulose-7-Phosphate | hmdbid:HMDB01068 | |
| + | ||
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 | |
| + | ||
| Glycolysis/Gluconeogenesis | ||
| Xylulose-5-Phosphate | hmdbid:HMDB00868 | |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 | |
| Nucleotide | chemical | |
| Biosynthesis |
| AGTR1 | uniprot | |
| ATP8A1 | uniprot | |
| AGTR1 | uniprot | |
| AGTR2 | uniprot | |
| BDKRB2 | uniprot | |
| BDKRB1 | uniprot | |
| NMBR | uniprot | |
| GRPR | uniprot | |
| BRS3 | uniprot | |
| CCR1 | uniprot | |
| CCR2 | uniprot | |
| CCR3 | uniprot | |
| CCR4 | uniprot | |
| CCR5 | uniprot | |
| CCR6 | uniprot | |
| CCR7 | uniprot | |
| CCR8 | uniprot | |
| CCR-9 | uniprot | |
| CCR10 | uniprot | |
| CCR1 | uniprot | |
| CXCR6 | uniprot | |
| CXCR3 | uniprot | |
| CXCR4 | uniprot | |
| BLR1 | uniprot | |
| FY | ||
| CX3CR1 | uniprot | |
| FSHR | uniprot | |
| LHCGR | uniprot | |
| TSHR | uniprot | |
| GALR1 | uniprot | |
| GALR2 | uniprot | |
| GALR3 | uniprot | |
| EDNRA | uniprot | |
| EDNRB | uniprot | |
| CCKAR | uniprot | |
| CCKBR | uniprot | |
| FPR1 | uniprot | |
| FPRL1 | uniprot | |
| FPRL2 | uniprot | |
| C3AR1 | uniprot | |
| IL8RA | uniprot | |
| IL8RB | uniprot | |
| MC1R | uniprot | |
| MC3R | uniprot | |
| MC4R | uniprot | |
| MC5R | uniprot | |
| NPY1R | uniprot | |
| NPY2R | uniprot | |
| NPY5R | uniprot | |
| NTSR1 | uniprot | |
| NTSR2 | uniprot | |
| OPRD1 | uniprot | |
| OPRK1 | uniprot | |
| OPRM1 | uniprot | |
| OPRL1 | uniprot | |
| GNRHR | uniprot | |
| TRHR | uniprot | |
| GHSR | uniprot | |
| TACR1 | uniprot | |
| TACR2 | uniprot | |
| TACR3 | uniprot | |
| TAC4 | ||
| SSTR1 | uniprot | |
| SSTR2 | uniprot | |
| SSTR3 | uniprot | |
| SSTR4 | uniprot | |
| SSTR5 | uniprot | |
| AVPR1A | uniprot | |
| AVPR1B | uniprot | |
| AVPR2 | uniprot | |
| OXTR | uniprot | |
| C5R1 | uniprot | |
| MC2R | uniprot | |
| PPYR1 | uniprot | |
| NPY6R | uniprot | |
| Releasing Hormone | ||
| Receptors | ||
| Opioid Receptors | ||
| Neuropeptide Y Receptors | uniprot | |
| Neurotensin Receptors | ||
| Chemokine Receptors | ||
| Chemotactic Receptors | ||
| Angiotensin Receptors | ||
| Bombesin Receptors | ||
| Endothelin Receptors | ||
| Vasopressin and | ||
| Oxytocin | hmdbid:HMDB02865 | uniprot |
| Galanin Receptors | ||
| Receptors | ||
| Glycoprotein Hormone | ||
| Receptors | ||
| Cholecystokinin/ | ||
| Bradykinin Receptors | ||
| Somatostatin Receptors | ||
| Tachykinin Receptors | ||
| Gq Coupled | ||
| Gi Coupled | ||
| Gs Coupled | ||
| Gastrin Receptors | ||
| Melanocortin | chemical |
| PTGS1 | uniprot | |
| PTGS2 | uniprot | |
| ANXA3 | uniprot | |
| ANXA2 | uniprot | |
| ANXA1 | uniprot | |
| ANXA6 | uniprot | |
| ANXA4 | uniprot | |
| SCGB1A1 | uniprot | |
| ANXA5 | uniprot | |
| ANXA8 | uniprot | |
| S100A6 | uniprot | |
| HSD11B1 | uniprot | |
| EDNRB | uniprot | |
| EDN1 | uniprot | |
| HPGD | uniprot | |
| PRL | uniprot | |
| EDNRA | uniprot | |
| HSD11B2 | uniprot | |
| CYP11A1 | uniprot | |
| PLA2G4A | uniprot | |
| S100A10 | uniprot | |
| PTGIS | uniprot | |
| PTGDS | uniprot | |
| TBXAS1 | uniprot | |
| PTGDR | uniprot | |
| PTGER1 | uniprot | |
| PTGER2 | uniprot | |
| PTGER3 | uniprot | |
| PTGER4 | uniprot | |
| PTGFR | uniprot | |
| PTGIR | uniprot | |
| PGF2 | uniprot | |
| PGI2 | hmdbid:HMDB01335 | uniprot |
| Ca | ||
| 2+ | ||
| Prostaglandin H2 | hmdbid:HMDB01381 | |
| TXA2 | hmdbid:HMDB01452 | |
| Cortisol | hmdbid:HMDB00063 | |
| PGE2 | hmdbid:HMDB01220 | |
| Cell Membrane | ||
| Phospholipids | CHEBI:16247 | |
| Inactive Metabolites | ||
| Cytoplasm | ||
| PG Synthases | ||
| Cortisone | hmdbid:HMDB02802 | |
| Cortisol | hmdbid:HMDB00063 | |
| Arachidonic Acid | hmdbid:HMDB01043 | |
| Progesterone | hmdbid:HMDB01830 | |
| Gq signaling | ||
| pathway | ||
| PGF2 | uniprot | |
| Annexins | chemical | |
| release | ||
| prolactin | uniprot | |
| Annexins | chemical | |
| Ca | ||
| 2+ | ||
| PG Synthases | ||
| PG Receptors | ||
| PG Receptors |
| H2AFX | uniprot | |
| H2AFZ | uniprot | |
| UBE1 | uniprot | |
| UBE1L | uniprot | |
| UBE2B | uniprot | |
| UBE2D1 | uniprot | |
| UBE2D2 | uniprot | |
| UBE2D3 | uniprot | |
| PSMC1 | uniprot | |
| NEDD4 | uniprot | |
| PSMC6 | uniprot | |
| PSMD1 | uniprot | |
| PSMD2 | uniprot | |
| PSMD3 | uniprot | |
| PSMD4 | uniprot | |
| PSMC5 | uniprot | |
| PSMC2 | uniprot | |
| PSMC3 | uniprot | |
| PSMC4 | uniprot | |
| PSMA1 | uniprot | |
| PSMA2 | uniprot | |
| PSMB1 | uniprot | |
| PSMA3 | uniprot | |
| PSMA4 | uniprot | |
| PSMB3 | uniprot | |
| PSMB6 | uniprot | |
| PSMB7 | uniprot | |
| PSMB5 | uniprot | |
| PSMB4 | uniprot | |
| PSME1 | uniprot | |
| PSME2 | uniprot | |
| IFNG | uniprot | |
| PSMB9 | uniprot | |
| PSMB10 | uniprot | |
| PSMB8 | uniprot | |
| PSME3 | uniprot | |
| PSMD7 | uniprot | |
| PSMD6 | uniprot | |
| PSMD8 | uniprot | |
| PSMD9 | uniprot | |
| PSMD10 | uniprot | |
| PSMD11 | uniprot | |
| PSMD12 | uniprot | |
| PSMD13 | uniprot | |
| PSMC5 | uniprot | |
| PSMA6 | uniprot | |
| PSMA7 | uniprot | |
| PSMA5 | uniprot | |
| PSMB2 | uniprot | |
| HLA-A | uniprot | |
| HLA-B | uniprot | |
| HLA-C | uniprot | |
| HLA-E | uniprot | |
| HLA-F | uniprot | |
| HLA-G | uniprot | |
| RPN2 | uniprot | |
| RPN1 | uniprot | |
| UBC | uniprot | |
| PSMD5 | uniprot | |
| HLA-H | uniprot | |
| HLA-J | ||
| HIST1H2AB | uniprot | |
| ATP | hmdbid:HMDB00538 | |
| AMP Ubiquitin/E1 Complex | ||
| Ubiquitin/E2 Complex | ||
| E3/Protein | ||
| Proteins to be Degraded | ||
| Ubiquitin/Protein | ||
| Proteasome 26 S | ||
| (PA700) (ATP dependent) | ||
| p45 ATPase Subunit | ||
| Unfolds and Degrades | ||
| Intact Proteins | ||
| Proteasome 20S | ||
| Catalytic Core (p45) | ||
| Activators of | ||
| Degrades only Peptides | ||
| Presentation by MHC class 1 | ||
| Oxidatively Damaged | ||
| Cytosolic Proteins | ||
| 20S Complex | ||
| Lid subunits | ||
| Alpha subunits | ||
| Beta subunits |
| EGFR | uniprot |
| ITGA1 | uniprot |
| F2R | uniprot |
| F2 | |
| FN1 | uniprot |
| GNA12 | uniprot |
| SOS1 | uniprot |
| GNA13 | uniprot |
| ARHGEF6 | uniprot |
| CSK | uniprot |
| VAV1 | uniprot |
| BCAR1 | uniprot |
| CRK | uniprot |
| PTK2 | uniprot |
| MOS | uniprot |
| MAP2K1 | uniprot |
| MAPK1 | uniprot |
| CHRM1 | uniprot |
| GNG12 | uniprot |
| FGD1 | uniprot |
| CDC42 | uniprot |
| IQGAP1 | uniprot |
| ARHGEF1 | uniprot |
| BAIAP2 | uniprot |
| ENAH | uniprot |
| WAS | |
| ARPC5 | uniprot |
| ACTB | uniprot |
| RHOA | uniprot |
| ROCK1 | uniprot |
| GRLF1 | uniprot |
| RAC1 | uniprot |
| RAC3 | uniprot |
| RAC2 | uniprot |
| CD14 | uniprot |
| EGF | uniprot |
| FGF1 | uniprot |
| FGF2 | uniprot |
| FGF3 | uniprot |
| FGF4 | uniprot |
| FGF5 | uniprot |
| FGF9 | uniprot |
| FGF20 | uniprot |
| PDGFB | uniprot |
| FGF6 | uniprot |
| FGF11 | uniprot |
| FGF22 | uniprot |
| FGF7 | uniprot |
| FGF12 | uniprot |
| FGF17 | uniprot |
| FGF23 | uniprot |
| FGF8 | uniprot |
| FGF13 | uniprot |
| FGF18 | uniprot |
| FGF10 | uniprot |
| FGF21 | uniprot |
| FGFR1 | uniprot |
| FGFR3 | uniprot |
| FGFR2 | uniprot |
| FGFR4 | uniprot |
| PDGFRA | uniprot |
| PDGFRB | uniprot |
| SOS2 | uniprot |
| RRAS | uniprot |
| RRAS2 | uniprot |
| KRAS | uniprot |
| PIK3R4 | uniprot |
| PIK3C2A | uniprot |
| Pik3c2b | |
| PIK3C2G | uniprot |
| PIK3C3 | uniprot |
| PIK3CA | uniprot |
| PIK3CB | uniprot |
| PIK3CD | uniprot |
| PIK3CG | uniprot |
| PIK3R2 | uniprot |
| PIK3R1 | uniprot |
| PIK3R3 | uniprot |
| RAF1 | uniprot |
| BRAF | uniprot |
| MAP2K2 | uniprot |
| MAPK3 | uniprot |
| MAPK4 | uniprot |
| MAPK6 | uniprot |
| DOCK1 | uniprot |
| CHRM2 | uniprot |
| CHRM3 | uniprot |
| BDKRB2 | uniprot |
| BDKRB1 | uniprot |
| CHRM5 | uniprot |
| ROCK2 | uniprot |
| ARHGEF6 | uniprot |
| ARHGEF7 | uniprot |
| APC | uniprot |
| Apc2 | uniprot |
| PAK1 | uniprot |
| PAK2 | uniprot |
| PAK3 | uniprot |
| PAK4 | uniprot |
| PAK6 | uniprot |
| PAK7 | uniprot |
| PFN1 | uniprot |
| WASF2 | uniprot |
| BAIAP2 | uniprot |
| ARPC5 | uniprot |
| NCKAP1 | uniprot |
| WASF1 | uniprot |
| TMSB4X | uniprot |
| VIL2 | uniprot |
| GIT1 | uniprot |
| RDX | uniprot |
| SLC9A1 | uniprot |
| PIP5K2A | uniprot |
| MSN | uniprot |
| PIP5K1A | uniprot |
| PIP5K1B | uniprot |
| PIP5K2B | uniprot |
| PIP5K1C | uniprot |
| PFN1 | uniprot |
| PIP5K2C | |
| PIP5KL1 | |
| VCL | uniprot |
| ACTN1 | uniprot |
| PPP1R12A | uniprot |
| MYLK | uniprot |
| PIP5K2A | uniprot |
| LIMK1 | uniprot |
| MYL1 | uniprot |
| CFL1 | uniprot |
| MYL3 | uniprot |
| CFL2 | uniprot |
| VCL | uniprot |
| GSN | uniprot |
| MYH10 | uniprot |
| PIK3R5 | uniprot |
| MRAS | uniprot |
| NRAS | uniprot |
| C11orf13 | uniprot |
| INS1 | uniprot |
| INS2 | |
| FGF15 | uniprot |
| FGF14 | uniprot |
| FGF16 | uniprot |
| PDGFA | uniprot |
| ARHGEF4 | uniprot |
| CYFIP2 | |
| C3orf10 | |
| ACTB | uniprot |
| ACTG1 | uniprot |
| ACTG1 | uniprot |
| SSH3 | uniprot |
| SSH2 | uniprot |
| SSH1 | uniprot |
| RAC1P4 | |
| DIAP1 | uniprot |
| ACTB | uniprot |
| ACTG1 | uniprot |
| VIL1 | uniprot |
| PXN | uniprot |
| LOC442775 | |
| CHRM4 | uniprot |
| ABI2 | uniprot |
| DIAP3 | uniprot |
| Growth Factors | |
| Growth Factor (GF) | |
| RTK | |
| RTK | |
| RAS | uniprot |
| Ras | uniprot |
| PI3K | uniprot |
| PI3K | uniprot |
| Bradykinin | uniprot |
| Acetylcholine | hmdbid:HMDB00895 |
| Chemotatic factor | |
| LPS | CHEBI:16412 |
| PIP3 | uniprot |
| Actin | uniprot |
| polymerization | chemical |
| Focal adhesion | |
| assembly | |
| PIP2 | uniprot |
| PIP2 | uniprot |
| ? | |
| MAPK Signaling | |
| pathway | |
| Actin polymerization | |
| Stabilization | |
| of actin | |
| Lamellipodia | |
| -p | |
| +p | |
| Actin polymerization | |
| stress fiber | |
| Integrin-mediated | |
| cell adhesion | |
| Actomyosin | enzyme |
| assembly contraction | |
| Focal complex | |
| assembly | |
| Integrin-mediated | |
| cell adhesion | |
| stress fiber | |
| Gene Expression | |
| Cadherin-mediated | |
| cell adhesion | |
| Filipodia | |
| Chemotactic factor |
| TBP | uniprot |
| GTF2B | uniprot |
| TAF5 | uniprot |
| TAF6 | uniprot |
| TAF7 | uniprot |
| TAF9 | uniprot |
| ILK | uniprot |
| TAF12 | uniprot |
| TAF13 | uniprot |
| GTF2E1 | uniprot |
| GTF2A2 | uniprot |
| GTF2F2 | uniprot |
| GTF2E2 | uniprot |
| CDK7 | uniprot |
| GTF2H1 | uniprot |
| GTF2H2 | uniprot |
| GTF2H4 | uniprot |
| ERCC3 | uniprot |
| ERCC2 | uniprot |
| POLR1B | uniprot |
| POLR3B | uniprot |
| POLR2A | uniprot |
| POLR2F | uniprot |
| POLR2C | uniprot |
| POLR2E | uniprot |
| POLR2K | uniprot |
| POLR3D | uniprot |
| POLR3E | uniprot |
| POLR3H | uniprot |
| POLR3K | uniprot |
| POLR1A | uniprot |
| POLR2I | uniprot |
| POLR2G | uniprot |
| POLR2H | uniprot |
| POLR2J | uniprot |
| POLR2B | uniprot |
| CCNH | uniprot |
| MNAT1 | uniprot |
| GTF2H3 | uniprot |
| Polr1e | uniprot |
| POLR1D | uniprot |
| TATA | |
| 5 | |
| 3 | |
| 3 | |
| 5 | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| TATA | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| dsDNA | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| 5 | |
| Primary RNA transcript | |
| RNA polymerase II | enzyme |
| (mRNA, snRNPs) | |
| RNA polymerase I | enzyme |
| (large ribosomal RNAs) | |
| RNA polymerase III | enzyme |
| (small stable RNAs) | |
| cell growth | |
| Gene Regulatory Proteins | |
| (recognize surface DNA geometry) | |
| TFIID | uniprot |
| TFIIB | uniprot |
| Transcription Initiation Factors (TIFs) | |
| TFIIE | |
| TFIIA | |
| TFIIF | |
| TFIID | uniprot |
| TFIIB | uniprot |
| TFIIH | |
| TFIIF | |
| TATA | |
| TFIIF | |
| RNA pol II | |
| TFIIH | |
| TFIIE | |
| TATA Box binding | |
| protein | CHEBI:16541 |
| Steps 1) TBP binds TATA box | |
| Steps 2) Association of TIFs and RNA polymerase | |
| Steps 3) DNA melting by association with TFIIH | |
| Steps 4) Transcription elongation by NTPs | |
| Steps 5) RNA elongation with CDT phosphorylation | |
| TFIIA |
| SPHK1 | uniprot |
| SPHK2 | uniprot |
| ASAH1 | uniprot |
| LOC51190 | |
| EDG1 | uniprot |
| EDG5 | uniprot |
| EDG3 | uniprot |
| EDG8 | uniprot |
| PLCB1 | uniprot |
| PLCB2 | uniprot |
| PLCB3 | uniprot |
| MAPK3 | uniprot |
| MAPK1 | uniprot |
| MAPK6 | uniprot |
| MAPK4 | uniprot |
| MAPK7 | uniprot |
| MAPK12 | uniprot |
| GNAI1 | uniprot |
| GNAI2 | uniprot |
| GNAI3 | uniprot |
| AKT1 | uniprot |
| AKT2 | uniprot |
| AKT3 | uniprot |
| PIK3C2B | uniprot |
| RACGAP1 | uniprot |
| GPCRs similar to S1P |
| Sephs1 | uniprot | |
| Sephs2 | uniprot | |
| Sp1 | uniprot | |
| Sp3 | uniprot | |
| Jun | uniprot | |
| SBP2 | uniprot | |
| eEFSec | chemical | |
| Sars2 | uniprot | |
| Pstk | uniprot | |
| Cystathionine g-lyase | ||
| Scly | ||
| UGA | ||
| eEFSec | chemical | |
| GPX1 | uniprot | |
| GPX2 | uniprot | |
| GPX4 | uniprot | |
| DIO1 | uniprot | |
| SEPP1 | uniprot | |
| TXNRD1 | uniprot | |
| SepW | ||
| SPS2 | uniprot | |
| Sep15 | uniprot | |
| DIO2 | uniprot | |
| DIO3 | uniprot | |
| GPX3 | uniprot | |
| GPX6 | uniprot | |
| SelH | ||
| SelI | ||
| SelK | ||
| SelM | ||
| SEPN1 | uniprot | |
| SelO | ||
| SepX1 | ||
| SelS | ||
| SelT | ||
| TXNRD2 | uniprot | |
| TXNRD3 | ||
| SelV | ||
| Secp43 | chemical | |
| Sla | uniprot | |
| TXNRD3 | ||
| TXNRD2 | uniprot | |
| Selenbp1 | uniprot | |
| Fabp1 | uniprot | |
| Sars | uniprot | |
| TXNRD1 | uniprot | |
| Rpl30 | uniprot | |
| SBP2 | uniprot | |
| SBP2 | uniprot | |
| Pouf2f1 | ||
| Nfe2l2 | uniprot | |
| p105 | uniprot | |
| Crem | uniprot | |
| Fos | uniprot | |
| p65 | uniprot | |
| MethylSelenol MeSeH | ||
| H2Se | CHEBI:16503 | |
| Selenophosphate | hmdbid:HMDB06407 | |
| Phosphoseryl-tRNA[ser](sec) | chemical | |
| Seryl-tRNA[ser](sec) | chemical | |
| Sec tRNA[ser]sec | chemical | |
| Selenocysteyl-tRNA sec | ||
| ORGANIC Se | ||
| Diet | ||
| INORGANIC Se | ||
| Selenite | CHEBI:18212 | |
| methyl transferase | ||
| demethylation | chemical | |
| coding region | ||
| AUG | ||
| STOP | ||
| nucleus | CHEBI:33252 | |
| Antioxidant | CHEBI:22586 | |
| Redox | ||
| Thyroid hormone | ||
| enzymes | ||
| signalling | ||
| metabolism | ||
| Sec | ||
| synthesis | ||
| Se transport | ||
| and storage | ||
| Protein folding | ||
| Unkown | ||
| function | ||
| Selenoproteins | ||
| SeMet | ||
| Se = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = Thioredoxin | ||
| SeC | ||
| Selenate | CHEBI:15075 | |
| SeMet | ||
| SeC | ||
| Selenite | CHEBI:18212 | |
| Selenate | CHEBI:15075 | |
| GSH | hmdbid:HMDB00125 | |
| Body proteins | ||
| TrX | ||
| SeC Biosynthesis | ||
| SeC | ||
| Selenium binding proteins | ||
| Transcription Factors | ||
| SeC |
| ITGB1 | uniprot |
| ITGA1 | uniprot |
| PTK2B | uniprot |
| PXN | uniprot |
| PTK2 | uniprot |
| SRC | uniprot |
| PTEN | uniprot |
| PXN | uniprot |
| PTK2 | uniprot |
| SRC | uniprot |
| PTK2B | uniprot |
| RASA1 | uniprot |
| PIK3CA | uniprot |
| GAB1 | uniprot |
| PTPN11 | uniprot |
| GRB2 | uniprot |
| STAT3 | uniprot |
| SOS1 | uniprot |
| CRKL | uniprot |
| CRK | uniprot |
| DOCK1 | uniprot |
| RAPGEF1 | uniprot |
| RAP1A | uniprot |
| RAP1B | uniprot |
| HRAS | uniprot |
| MAPK8 | uniprot |
| MAP4K1 | uniprot |
| ELK1 | uniprot |
| RAF1 | uniprot |
| MAP2K1 | uniprot |
| MAP2K2 | uniprot |
| MAPK1 | uniprot |
| MAPK3 | uniprot |
| JUN | uniprot |
| FOS | uniprot |
| PAK1 | uniprot |
| Met | |
| HGF | uniprot |
| P | |
| P | |
| P | |
| Trancription | |
| Transcription | |
| AP-1 | uniprot |
| Transcription | |
| of Cox2 | |
| Anoikis | |
| AKT Pathway | |
| Actin | uniprot |
| RHO | uniprot |
| Pathway | |
| RAC1 | uniprot |
| Pathway | |
| CDC42 | uniprot |
| Pathway | |
| Changes in Cytoskeleton | |
| and Cell mobility | |
| Extracellular | |
| Cytoplasm | |
| Right Click for Comments |
| CNR1 | uniprot |
| CNR2 | uniprot |
| EDG1 | uniprot |
| EDG2 | uniprot |
| EDG3 | uniprot |
| EDG5 | uniprot |
| EDG6 | uniprot |
| MTNR1A | uniprot |
| PTAFR | uniprot |
| PTGDR | uniprot |
| PTGER1 | uniprot |
| PTGER2 | uniprot |
| PTGER3 | uniprot |
| PTGER4 | uniprot |
| PTGFR | uniprot |
| PTGIR | uniprot |
| TBXA2R | uniprot |
| MTNR1B | uniprot |
| Mel-1C | |
| Prostanoids | CHEBI:26347 |
| Melatonin | hmdbid:HMDB01389 |
| Platelet Activating | |
| Lysophosphatidic | chemical |
| Acid | CHEBI:37527 |
| Cannabinoid | chemical |
| Gq/G11 Pathway | |
| Gq/G11 Pathway | |
| Gi Pathway |
| PRKAR1B | uniprot | |
| ADCY2 | uniprot | |
| PRKCA | uniprot | |
| PRKCB1 | uniprot | |
| PRKCC | ||
| PRKCD | uniprot | |
| PRKCG | uniprot | |
| PRKCH | uniprot | |
| PRKD1 | uniprot | |
| PRKCQ | uniprot | |
| PRKCZ | uniprot | |
| PRKCE | uniprot | |
| PRKACB | uniprot | |
| ADCY6 | uniprot | |
| ADCY8 | uniprot | |
| PRKAR2A | uniprot | |
| PRKAR2B | uniprot | |
| PRKACA | uniprot | |
| ADCY9 | uniprot | |
| PRKAR1A | uniprot | |
| ADCY3 | uniprot | |
| ADCY5 | uniprot | |
| CORIN | uniprot | |
| RGS1 | uniprot | |
| RGS3 | uniprot | |
| RGS4 | uniprot | |
| RGS5 | uniprot | |
| RGS6 | uniprot | |
| RGS7 | uniprot | |
| RGS9 | uniprot | |
| RGS10 | uniprot | |
| RGS11 | uniprot | |
| RGS14 | uniprot | |
| RGS16 | uniprot | |
| RGS17 | uniprot | |
| RGS18 | uniprot | |
| RGS19 | uniprot | |
| RGS20 | uniprot | |
| ADCY4 | uniprot | |
| ADCY1 | uniprot | |
| RGS2 | uniprot | |
| ADCY7 | uniprot | |
| GABPB2 | uniprot | |
| SP1 | uniprot | |
| NFKB1 | uniprot | |
| ETS2 | uniprot | |
| IGFBP1 | uniprot | |
| IGFBP2 | uniprot | |
| IGFBP4 | uniprot | |
| ADM | uniprot | |
| OXTR | uniprot | |
| IGFBP6 | uniprot | |
| LGR7 | uniprot | |
| NOS1 | uniprot | |
| CRH | uniprot | |
| IGFBP3 | uniprot | |
| CRHR1 | uniprot | |
| RLN1 | uniprot | |
| NOS3 | uniprot | |
| FOS | uniprot | |
| OXT | hmdbid:HMDB02865 | uniprot |
| YWHAZ | uniprot | |
| YWHAE | uniprot | |
| YWHAH | uniprot | |
| YWHAG | uniprot | |
| SFN | uniprot | |
| YWHAQ | uniprot | |
| GJA1 | uniprot | |
| IL1B | uniprot | |
| IL6 | uniprot | |
| GNAQ | uniprot | |
| CMKOR1 | uniprot | |
| ADMR | uniprot | |
| OXTR | uniprot | |
| JUN | uniprot | |
| PDE4B | uniprot | |
| PDE4D | uniprot | |
| CAMK2D | uniprot | |
| YWHAB | uniprot | |
| CALM1 | uniprot | |
| CAMK2B | uniprot | |
| GABPA | uniprot | |
| CAMK2A | uniprot | |
| MAFF | uniprot | |
| LGR8 | uniprot | |
| IGFBP5 | uniprot | |
| CNN1 | uniprot | |
| CNN2 | uniprot | |
| MYL4 | uniprot | |
| MYL2 | uniprot | |
| ITPR1 | uniprot | |
| GUCA2A | uniprot | |
| GUCA2B | uniprot | |
| GUCY2E | ||
| GUCY1A3 | uniprot | |
| GRK5 | uniprot | |
| GRK6 | uniprot | |
| GNB1 | uniprot | |
| GNB2 | uniprot | |
| GNB3 | uniprot | |
| GNB4 | uniprot | |
| GNB5 | uniprot | |
| GNGT1 | uniprot | |
| GNG2 | uniprot | |
| GNG3 | uniprot | |
| GNG4 | uniprot | |
| GNG7 | uniprot | |
| GNG8 | uniprot | |
| GNG12 | uniprot | |
| GNG13 | uniprot | |
| GNG5 | uniprot | |
| GNG11 | uniprot | |
| ATF2 | uniprot | |
| ATF3 | uniprot | |
| CREB3 | uniprot | |
| ATF5 | uniprot | |
| ATF4 | uniprot | |
| ATF1 | uniprot | |
| CREB1 | uniprot | |
| GRK4 | uniprot | |
| GNAS | uniprot | |
| CALM2 | uniprot | |
| PKIA | uniprot | |
| PKIB | uniprot | |
| PKIG | uniprot | |
| CALCA | uniprot | |
| RCP9 | ||
| CALM3 | uniprot | |
| CREBL1 | uniprot | |
| ITPR2 | uniprot | |
| ITPR3 | uniprot | |
| DGKZ | uniprot | |
| PLCD1 | uniprot | |
| PLCG1 | uniprot | |
| PLCG2 | uniprot | |
| PLCB3 | uniprot | |
| GSTO1 | uniprot | |
| RYR3 | uniprot | |
| ATP2A2 | uniprot | |
| ARRB1 | uniprot | |
| ARRB2 | uniprot | |
| CACNB3 | uniprot | |
| SLC8A1 | uniprot | |
| EDG2 | uniprot | |
| CALD1 | uniprot | |
| ACTA1 | uniprot | |
| ACTA2 | uniprot | |
| ACTB | uniprot | |
| ACTC | uniprot | |
| ACTG1 | uniprot | |
| RAMP1 | uniprot | |
| RAMP2 | uniprot | |
| RAMP3 | uniprot | |
| CAMK2G | uniprot | |
| MYLK2 | uniprot | |
| RYR1 | uniprot | |
| ATP2A3 | uniprot | |
| RYR2 | uniprot | |
| Protein Kinase A | uniprot | |
| Protein Kinase C | uniprot | |
| TR | ||
| TR = Transcriptional Regulation | ||
| note: see gene backpages for references | ||
| Regulators of G-protein | ||
| Signaling | ||
| IGFBP | ||
| Adenylyl Cyclases | ||
| Activation Via CRH and cAMP | ||
| PKC inhibitor Protein-1 | ||
| Pathways of Myometrial Relaxation | ||
| Pathways of Myometrial Contraction | ||
| cAMP | hmdbid:HMDB00058 | |
| cGMP | hmdbid:HMDB01314 | |
| Predicted OT-R | ||
| Predicted Cxn43 | ||
| Ets complex | ||
| Pge2 | chemical | |
| Nucleus | CHEBI:33252 | |
| AP-1 complex | ||
| Myometrial Relaxation | ||
| Adenylyl Cyclases | enzyme | uniprot |
| PKA | enzyme | |
| Myometrial Contraction | ||
| PKC | enzyme | uniprot |
| PKC inhibitor 1 | ||
| RGS | hmdbid:HMDB00131 | uniprot |
| G | ||
| bg | ||
| bg | ||
| DAG | uniprot | |
| G | ||
| Calcium Mobilization | ||
| IGFBP | ||
| TR | ||
| NO | ||
| Transcriptional | ||
| CRE-Transcription Factors | ||
| bg | ||
| G | ||
| IP3 | ||
| Pip2 | chemical | |
| GRK | ||
| GRK | ||
| Cell Growth | ||
| GPCR Kinase | enzyme | |
| PKA Inhibitors | ||
| Regulators | ||
| Phospholipase-C | chemical | |
| Camk2 | ||
| IP3 Receptor | ||
| SR | ||
| IP3 Receptor | ||
| Calmodulin | uniprot | |
| Phospholipase-C | chemical | |
| CAM-Kinase 2 | ||
| beta Arrestin | ||
| beta Arrestin | ||
| beta Arrestin | ||
| Calcium Influx | ||
| + | ||
| Ca | ||
| 2+ | ||
| LPA | uniprot | |
| Ca | ||
| 2+ | ||
| Na | ||
| cAMP | hmdbid:HMDB00058 | |
| MAPK | enzyme | uniprot |
| 2+ | ||
| Mg | ||
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| Mlck | ||
| P | ||
| - | ||
| ATP | hmdbid:HMDB00538 | |
| Pi + ADP | ||
| RAMP | uniprot | |
| RAMP | uniprot | |
| Ca++/Calmodulin | ||
| Ryr | ||
| Ryanodine Receptor (Ryr) |
| HMGCR | uniprot | |
| CYP7A1 | uniprot | |
| SOAT1 | uniprot | |
| DGAT1 | uniprot | |
| LDLR | uniprot | |
| SCARB1 | uniprot | |
| LRP1 | uniprot | |
| LPL | enzyme | uniprot |
| LIPC | uniprot | |
| CETP | uniprot | |
| LCAT | enzyme | uniprot |
| ABCA1 | uniprot | |
| APOA1 | uniprot | |
| APOA4 | uniprot | |
| APOC1 | uniprot | |
| APOE | uniprot | |
| APOC2 | uniprot | |
| APOC3 | uniprot | |
| TRNP | ||
| PLTP | uniprot | |
| Cell Membrane | ||
| Statin | hmdbid:HMDB05007 | |
| acetylCoA | hmdbid:HMDB01206 | uniprot |
| Cholesterol | hmdbid:HMDB00067 | |
| Cholic Acid | hmdbid:HMDB00619 | |
| Free FA | ||
| Cholesterol Ester | ||
| Phospholipid | CHEBI:16247 | |
| Triglycerides | chemical | |
| Liver cell | ||
| LDL | ||
| IDL | ||
| VLDL | ||
| HDL | ||
| Cholesterol | hmdbid:HMDB00067 | |
| Tissues | ||
| Plasma | ||
| Represses | ||
| Activates | ||
| Legend |
| HSD3B1 | uniprot |
| HSD3B2 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B2 | uniprot |
| HSD3B2 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| CYP17A1 | uniprot |
| Hydroxyprogesterone aldolase | |
| CYP17A1 | uniprot |
| Hydroxyprogesterone aldolase | |
| HSD3B1 | uniprot |
| F13B | uniprot |
| Steroid-19-Hydroxylase | chemical |
| Steroid-19-Hydroxylase | chemical |
| HSD17B1 | uniprot |
| HSD17B2 | uniprot |
| HSD17B3 | uniprot |
| HSD17B4 | uniprot |
| HSD17B7 | uniprot |
| HSD3B1 | uniprot |
| HSD3B2 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| HSD3B1 | uniprot |
| Cholesterol | hmdbid:HMDB00067 |
| Pregnenolone | hmdbid:HMDB00253 |
| Progesterone | hmdbid:HMDB01830 |
| 17-alpha-OH-Pregnenolone | chemical |
| 17-alpha-OH-Progesterone | chemical |
| DHA | hmdbid:HMDB00077 |
| Androstenedione | hmdbid:HMDB00053 |
| Androstenediol | hmdbid:HMDB03818 |
| Testosterone | hmdbid:HMDB02998 |
| Dihydrotestosterone | hmdbid:HMDB02961 |
| Estrone | hmdbid:HMDB01425 |
| Estradiol | hmdbid:HMDB00151 |
| * 3-beta-OH-delta-steroid DH & Steroid isomerase = | |
| ** Estradiol-17-beta DH = DHB | |
| To Mineralcorticoid Synthesis | |
| To Glucocorticoid Synthesis | |
| * | |
| * | |
| ** | |
| * | |
| * |
| MYL4 | uniprot |
| MYL2 | uniprot |
| MYH6 | uniprot |
| MYH8 | uniprot |
| ACTA1 | uniprot |
| ACTC | uniprot |
| TNNI1 | uniprot |
| TNNT2 | uniprot |
| TPM3 | uniprot |
| DMD | uniprot |
| VIM | uniprot |
| TPM2 | uniprot |
| TNNI2 | uniprot |
| TNNI3 | uniprot |
| TNNT3 | uniprot |
| TNNT1 | uniprot |
| TNNC1 | uniprot |
| TNNC2 | uniprot |
| MYL3 | uniprot |
| MYL1 | uniprot |
| MYH3 | uniprot |
| ACTN2 | uniprot |
| ACTN4 | uniprot |
| TMOD1 | uniprot |
| MYOM1 | uniprot |
| TCAP | uniprot |
| TTN | uniprot |
| DES | |
| TPM4 | uniprot |
| TPM1 | uniprot |
| MYBPC3 | uniprot |
| MYBPC2 | uniprot |
| MYBPC1 | uniprot |
| ACTA2 | uniprot |
| ACTG1 | uniprot |
| MYL9 | uniprot |
| ACTN3 | uniprot |
| NEB | uniprot |
| Myosin Light Chain | |
| Myosin Heavy Chain | uniprot |
| Tropomyosin | uniprot |
| Other Structural | |
| M Disk | |
| Z Disk | |
| Z Disk | |
| Myosin Binding | |
| A Model of Triggering of Striated Muscle | |
| Contraction by Ca++ | |
| Troponin-T | uniprot |
| Troponin-I | uniprot |
| Troponin-C | uniprot |
| Actin | uniprot |
| Actin | uniprot |
| Myosin Binding Site | |
| (Covered) | |
| Ca | |
| Ca | |
| Myosin Head | |
| Regulatory Proteins |
| ACAT1 | uniprot | |
| HMGCS2 | uniprot | |
| HMGCL | uniprot | |
| OXCT1 | uniprot | |
| BDH | uniprot | |
| 3-Hydroxy-butyrate | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Acetoacetyl-CoA | hmdbid:HMDB01484 | |
| 3-Hydroxy-3-methylglutaryl-CoA | hmdbid:HMDB01375 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Pyruvate metabolism | ||
| Fatty acid metabolism | ||
| Sterol biosynthesis | ||
| Acetoacetate | hmdbid:HMDB00060 | |
| Fatty acid beta-oxidation | ||
| Glycolysis | ||
| (HMG-CoA cycle) | ||
| * pathway-regulated enzymes: HMG-CoA synthase, mt |
| TRA@ | ||
| TRB@ | ||
| CD3G | uniprot | |
| CD3D | uniprot | |
| CD3E | uniprot | |
| CD5 | uniprot | |
| PTPN6 | uniprot | |
| NCK1 | uniprot | |
| SLA | uniprot | |
| SYK | uniprot | |
| CBL | uniprot | |
| PIK3R1 | uniprot | |
| PIK3R2 | uniprot | |
| TRAT1 | uniprot | |
| LAX1 | uniprot | |
| GAB2 | uniprot | |
| SHC1 | uniprot | |
| PRKCQ | uniprot | |
| VAV1 | uniprot | |
| FYB | uniprot | |
| DUSP3 | uniprot | |
| PTPN3 | uniprot | |
| PTPN12 | uniprot | |
| MAP2K1 | uniprot | |
| MAPK1 | uniprot | |
| PRKD2 | uniprot | |
| SIT1 | uniprot | |
| PTPN11 | uniprot | |
| MAP3K1 | uniprot | |
| PTPRH | ||
| MAP2K2 | uniprot | |
| MAPK3 | uniprot | |
| VAV3 | uniprot | |
| VAV2 | uniprot | |
| STAT1 | uniprot | |
| STAT5A | uniprot | |
| MAPK7 | uniprot | |
| JAK3 | uniprot | |
| SH2D3C | uniprot | |
| BCL10 | uniprot | |
| PAK1 | uniprot | |
| SCAP1 | ||
| SCAP2 | ||
| SOS2 | uniprot | |
| DBNL | uniprot | |
| ABL1 | uniprot | |
| RASA1 | uniprot | |
| PTPN22 | uniprot | |
| CRKL | uniprot | |
| CTNNB1 | uniprot | |
| CBLB | uniprot | |
| SHB | uniprot | |
| SRC | uniprot | |
| PTK2 | uniprot | |
| AKT1 | uniprot | |
| CD4 | uniprot | |
| CD8A | uniprot | |
| SH3BP2 | uniprot | |
| STAT5B | uniprot | |
| CD2 | uniprot | |
| RAP1A | uniprot | |
| LYN | uniprot | |
| RAC2 | uniprot | |
| CD3Z | uniprot | |
| CD3Z | uniprot | |
| FYN | uniprot | |
| ZAP70 | uniprot | |
| LCK | uniprot | |
| MAP4K1 | uniprot | |
| MUC1 | uniprot | |
| TUBB | uniprot | |
| FCRL3 | ||
| SLA2 | uniprot | |
| CARD11 | uniprot | |
| WASPIP | uniprot | |
| NFAM1 | uniprot | |
| DEF6 | uniprot | |
| WAS | ||
| GRAP | uniprot | |
| GRAP2 | uniprot | |
| LCP2 | uniprot | |
| ARHGDIB | uniprot | |
| CRK | uniprot | |
| DTX1 | uniprot | |
| NEDD9 | uniprot | |
| RAPGEF1 | uniprot | |
| PSTPIP1 | uniprot | |
| LAT | enzyme | uniprot |
| GRB2 | uniprot | |
| SOS1 | uniprot | |
| PLCG1 | uniprot | |
| PXN | uniprot | |
| ARHGEF7 | uniprot | |
| TXK | uniprot | |
| KHDRBS1 | uniprot | |
| NCL | uniprot | |
| UNC119 | uniprot | |
| TUBA1 | uniprot | |
| ITK | uniprot | |
| DNM2 | uniprot | |
| DLG1 | uniprot | |
| CREB1 | uniprot | |
| CREBBP | uniprot | |
| ARHGEF6 | uniprot | |
| GIT2 | uniprot | |
| VASP | uniprot | |
| ENAH | uniprot | |
| EVL | uniprot | |
| CDC42 | uniprot | |
| FYB | uniprot | |
| LCP2 | uniprot | |
| NCK1 | uniprot | |
| PTPRC | uniprot | |
| SH2D2A | uniprot | |
| WASF2 | uniprot | |
| ABI1 | uniprot | |
| PAG1 | uniprot | |
| RASGRP2 | ||
| CD2AP | uniprot | |
| HOMER3 | uniprot | |
| CEBPB | uniprot | |
| PPP3CB | uniprot | |
| CABIN1 | uniprot | |
| NFATC2 | uniprot | |
| ITPR1 | uniprot | |
| YWHAQ | uniprot | |
| JUN | uniprot | |
| JUN | uniprot | |
| FOS | uniprot | |
| CISH | uniprot | |
| DOCK2 | uniprot | |
| RIPK2 | uniprot | |
| LIME1 | uniprot | |
| ACP1 | uniprot | |
| LNK | uniprot | |
| STK39 | uniprot | |
| HDAC7A | uniprot | |
| STAT5A | uniprot | |
| STAT5B | uniprot | |
| LIME1 | uniprot | |
| HDAC7A | uniprot | |
| BRAF | uniprot | |
| PTK2B | uniprot | |
| PTPRJ | uniprot | |
| CD3E | uniprot | |
| Antigen | ||
| Molecular association | ||
| Methylation | chemical | |
| Glycosylation | ||
| Autophosphorylation | chemical | |
| Demethylation | chemical | |
| Translocation | ||
| Cytoplasm | ||
| Endoplasmic reticulum | ||
| Endosome | ||
| Palmitoylation | chemical | |
| Phosphorylation | chemical | |
| CY->NU | ||
| CY->NU | ||
| CY->PM | ||
| NU->CY | ||
| D | ||
| Receptor | ||
| Ligand | ||
| Gene Symbol | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| Enzyme complex | ||
| (Protein-protein interaction) | ||
| D | ||
| Reaction through unknown mechanisms/molecules | ||
| Accession Number: NetPath_11 | ||
| ER | ||
| CY | ||
| EN | ||
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Sumoylation | chemical | |
| Desumoylation | ||
| Ubiquitination | ||
| Deubiquitination | ||
| Activation | chemical | |
| Inhibition | chemical | |
| Recruitment | ||
| Control | ||
| EC | ||
| Extracellular | ||
| Golgi apparatus | ||
| GO | ||
| Mitochondrion | ||
| MT | ||
| Nucleus | CHEBI:33252 | |
| NU | ||
| Plasma membrane | ||
| PM |
| TGFB1 | uniprot |
| TGFBR1 | uniprot |
| TGFBR2 | uniprot |
| SMAD2 | uniprot |
| DAB2 | uniprot |
| SMAD7 | uniprot |
| SMURF1 | uniprot |
| TGFBR3 | uniprot |
| TGFBR2 | uniprot |
| TGFB2 | uniprot |
| ARRB2 | uniprot |
| TGFB3 | uniprot |
| TGFBR1 | uniprot |
| TGFBR2 | uniprot |
| SMAD3 | uniprot |
| STRAP | uniprot |
| SMAD6 | uniprot |
| TGFBR2 | uniprot |
| TGFBR3 | uniprot |
| TGFB1 | uniprot |
| SPARC | uniprot |
| SDC2 | uniprot |
| CD44 | uniprot |
| AP2B1 | uniprot |
| SMAD4 | uniprot |
| ZFYVE9 | uniprot |
| DAXX | uniprot |
| FKBP1A | uniprot |
| FNTA | uniprot |
| ERBB2IP | uniprot |
| GIPC1 | uniprot |
| PIK3R1 | uniprot |
| CTNNB1 | uniprot |
| ENG | uniprot |
| CAV1 | uniprot |
| EIF3S2 | uniprot |
| AXIN1 | uniprot |
| SNX6 | uniprot |
| VDR | uniprot |
| PRKAR2A | uniprot |
| PRKAR1B | uniprot |
| TCF8 | uniprot |
| TGIF | uniprot |
| NUP214 | uniprot |
| PIK3R2 | uniprot |
| PARD3 | uniprot |
| HGS | uniprot |
| TGFBR1 | uniprot |
| TGFBR2 | uniprot |
| TGFBR2 | uniprot |
| TGFBR3 | uniprot |
| TGFBR2 | uniprot |
| TGFBR1 | uniprot |
| TGFB1 | uniprot |
| TGFB3 | uniprot |
| TGFB2 | uniprot |
| TGFB2 | uniprot |
| TGFBR3 | uniprot |
| TGFBR2 | uniprot |
| TGFB1 | uniprot |
| TGFBR2 | uniprot |
| TGFBR3 | uniprot |
| TGFBR3 | uniprot |
| TGFBR2 | uniprot |
| TGFB3 | uniprot |
| TGFB3 | uniprot |
| LEF1 | uniprot |
| HDAC1 | uniprot |
| MEF2C | uniprot |
| MEF2A | uniprot |
| RUNX2 | uniprot |
| MYC | uniprot |
| SP1 | uniprot |
| NUP153 | uniprot |
| SMAD2 | uniprot |
| NFYC | uniprot |
| SNIP1 | uniprot |
| ZFHX1B | uniprot |
| FOXH1 | uniprot |
| PCAF | uniprot |
| EP300 | uniprot |
| CDC27 | uniprot |
| SKIL | uniprot |
| ESR1 | uniprot |
| SMAD4 | uniprot |
| SMAD3 | uniprot |
| RBX1 | uniprot |
| CUL1 | uniprot |
| DVL1 | uniprot |
| FOXO3A | uniprot |
| TP53 | uniprot |
| TP73 | uniprot |
| SNW1 | uniprot |
| CRI2 | |
| STAMBPL1 | uniprot |
| FOXO1A | uniprot |
| ATF2 | uniprot |
| CITED1 | uniprot |
| JUND | uniprot |
| FOS | uniprot |
| RBL1 | uniprot |
| APC10 | uniprot |
| ANAPC1 | uniprot |
| ANAPC4 | uniprot |
| CDC27 | uniprot |
| CDC16 | uniprot |
| CDC23 | uniprot |
| ANAPC2 | uniprot |
| ANAPC5 | uniprot |
| ANAPC7 | uniprot |
| E2F5 | uniprot |
| HNF4A | uniprot |
| E2F4 | uniprot |
| ANAPC1 | uniprot |
| ANAPC2 | uniprot |
| ANAPC5 | uniprot |
| ANAPC7 | uniprot |
| CDC27 | uniprot |
| CDC16 | uniprot |
| CDC23 | uniprot |
| ANAPC4 | uniprot |
| JUN | uniprot |
| SMAD3 | uniprot |
| SKI | uniprot |
| AR | |
| CTCF | uniprot |
| ATF3 | uniprot |
| ESR1 | uniprot |
| ETS1 | uniprot |
| AXIN2 | uniprot |
| MLLT7 | uniprot |
| JUNB | uniprot |
| FOSB | uniprot |
| TRAP1 | uniprot |
| STK11IP | |
| STK11 | uniprot |
| SUMO1 | uniprot |
| HOXA9 | uniprot |
| DCP1A | uniprot |
| COPS5 | uniprot |
| MAPK14 | uniprot |
| MAP3K7 | uniprot |
| SMAD7 | uniprot |
| SMURF1 | uniprot |
| YAP1 | uniprot |
| MAP2K6 | uniprot |
| MAP2K3 | uniprot |
| SMURF2 | uniprot |
| SMAD7 | uniprot |
| SMURF2 | uniprot |
| STRAP | uniprot |
| SNX6 | uniprot |
| SNX1 | uniprot |
| SNX2 | uniprot |
| SNX4 | uniprot |
| CDK2 | uniprot |
| CCNE1 | uniprot |
| TFDP1 | uniprot |
| SMAD3 | uniprot |
| TFDP2 | uniprot |
| CDKN1A | uniprot |
| NFYA | uniprot |
| NFYB | uniprot |
| FOXG1B | uniprot |
| CREBBP | uniprot |
| NCOA1 | uniprot |
| FZR1 | uniprot |
| RBL2 | uniprot |
| PPP2R2A | uniprot |
| APC10 | uniprot |
| ROCK1 | uniprot |
| CDC25A | uniprot |
| MAP3K7IP1 | uniprot |
| XPO1 | uniprot |
| HSPA8 | uniprot |
| ROCK1 | uniprot |
| RBL2 | uniprot |
| E2F4 | uniprot |
| E2F4 | uniprot |
| E2F4 | uniprot |
| RBL1 | uniprot |
| KPNB1 | uniprot |
| SMAD3 | uniprot |
| KPNB1 | uniprot |
| SMAD3 | uniprot |
| TFDP2 | uniprot |
| TFDP2 | uniprot |
| SMAD4 | uniprot |
| SMAD4 | uniprot |
| DCP1A | uniprot |
| SMAD2 | uniprot |
| SMAD2 | uniprot |
| RB1 | uniprot |
| RB1 | uniprot |
| MAPK8 | uniprot |
| CDK6 | uniprot |
| CDK4 | uniprot |
| CCND1 | uniprot |
| PRKCD | uniprot |
| PRKCG | uniprot |
| PRKCB1 | uniprot |
| RB1 | uniprot |
| PIAS1 | uniprot |
| PIAS2 | uniprot |
| UBE2D2 | uniprot |
| UBE2D1 | uniprot |
| UBE2D3 | uniprot |
| SKP1A | uniprot |
| BTRC | uniprot |
| RBX1 | uniprot |
| CUL1 | uniprot |
| CAMK2A | uniprot |
| CAMK2D | uniprot |
| CAMK2G | uniprot |
| CAMK2B | uniprot |
| E2F5 | uniprot |
| SKP1A | uniprot |
| CUL1 | uniprot |
| RBX1 | uniprot |
| BTRC | uniprot |
| SMAD3 | uniprot |
| RBL1 | uniprot |
| SMAD4 | uniprot |
| SMAD3 | uniprot |
| E2F4 | uniprot |
| E2F5 | uniprot |
| TFDP1 | uniprot |
| RBL1 | uniprot |
| SMAD4 | uniprot |
| E2F4 | uniprot |
| TFDP1 | uniprot |
| SMAD3 | uniprot |
| E2F5 | uniprot |
| E2F5 | uniprot |
| E2F5 | uniprot |
| RBL1 | uniprot |
| CDC2 | uniprot |
| CCNB2 | uniprot |
| MAPK14 | uniprot |
| MAPK8 | uniprot |
| Gene Symbol | |
| ACVRL1 | uniprot |
| NU -> CY | |
| NU -> CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Molecular association | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| Translocation | |
| CY | |
| Cytoplasm | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondria | |
| NU | |
| Nucleus | CHEBI:33252 |
| PM | |
| Plasma membrane | |
| Accession Number: NetPath_7; cellmap:7 |
| TGFB1 | uniprot |
| INHBA | uniprot |
| BMP4 | uniprot |
| TGFBR3 | uniprot |
| ENG | uniprot |
| TGFBR2 | uniprot |
| TGFBR1 | uniprot |
| FKBP1A | uniprot |
| LTBP1 | uniprot |
| FST | uniprot |
| NOG | uniprot |
| ITGB6 | uniprot |
| THBS1 | uniprot |
| TGFBR2 | uniprot |
| TGFBR1 | uniprot |
| ZFYVE9 | uniprot |
| SMAD1 | uniprot |
| SMAD5 | uniprot |
| SMAD9 | uniprot |
| SMAD2 | uniprot |
| SMAD3 | uniprot |
| SMAD4 | uniprot |
| IFNG | uniprot |
| TGFB1 | uniprot |
| BMP4 | uniprot |
| TNF | uniprot |
| EGF | uniprot |
| STAT1 | uniprot |
| SMAD2 | uniprot |
| SMAD1 | uniprot |
| NFKB1 | uniprot |
| SMAD7 | uniprot |
| SMAD6 | uniprot |
| MAPK3 | uniprot |
| HRAS | uniprot |
| WNT1 | uniprot |
| TNF | uniprot |
| CTNNB1 | uniprot |
| JAK1 | uniprot |
| MAPK9 | uniprot |
| SPP1 | uniprot |
| ZFHX1B | uniprot |
| RUNX2 | uniprot |
| RUNX3 | uniprot |
| LEF1 | uniprot |
| STAT3 | uniprot |
| JUN | uniprot |
| TFE3 | uniprot |
| FOXH1 | uniprot |
| ZNF423 | |
| EP300 | uniprot |
| CREBBP | uniprot |
| TGIF | uniprot |
| SKIL | uniprot |
| SKI | uniprot |
| SERPINE1 | uniprot |
| FOS | uniprot |
| LIF | uniprot |
| BAMBI | uniprot |
| ligands: | |
| Cofactor | CHEBI:23357 |
| Co-Smads | |
| Co-smads | |
| Repressors | |
| Cofactors | CHEBI:23357 |
| Rsmads | |
| R-Smads | |
| TGFb | |
| Accessory receptors: |
| TRAF6 | uniprot | |
| FLNA | uniprot | |
| PSMC3 | uniprot | |
| REL | uniprot | |
| NFKB1 | uniprot | |
| CYLD | uniprot | |
| IKBKG | uniprot | |
| TBK1 | enzyme | uniprot |
| TBKBP1 | ||
| PSMD6 | uniprot | |
| TRAIP | uniprot | |
| TRPC4AP | uniprot | |
| TRIAD3 | ||
| TNFRSF8 | uniprot | |
| CASP8AP2 | uniprot | |
| HSPB1 | uniprot | |
| TNFRSF1B | uniprot | |
| TNFRSF1B | uniprot | |
| TNFRSF1A | uniprot | |
| TNFRSF1A | uniprot | |
| TNF | uniprot | |
| TNF | uniprot | |
| TNF | uniprot | |
| TNF | uniprot | |
| TNF | uniprot | |
| PRKCZ | uniprot | |
| RELA | uniprot | |
| PRKACA | uniprot | |
| PPP2CA | uniprot | |
| UBCH5C | uniprot | |
| HIST3H3 | uniprot | |
| UBCH5B | uniprot | |
| CASP7 | uniprot | |
| MEKK2 | uniprot | |
| CAPN3 | uniprot | |
| CDC34 | uniprot | |
| NFKBIA | uniprot | |
| TRAF2 | uniprot | |
| TRADD | uniprot | |
| PSMD7 | uniprot | |
| PSMD3 | uniprot | |
| PSMD12 | uniprot | |
| NFKB2 | uniprot | |
| PSMD13 | uniprot | |
| T2BP | ||
| PSMD1 | uniprot | |
| RPL30 | uniprot | |
| RELB | uniprot | |
| SMARCC1 | uniprot | |
| CDC37 | uniprot | |
| RPL6 | uniprot | |
| SMARCA4 | uniprot | |
| HDAC1 | uniprot | |
| HDAC2 | uniprot | |
| KCNQ1 | uniprot | |
| KPNA3 | uniprot | |
| PSMB5 | uniprot | |
| FAF1 | uniprot | |
| PSMC1 | uniprot | |
| STAT1 | uniprot | |
| FADD | uniprot | |
| PSMC2 | uniprot | |
| PAPOLA | uniprot | |
| BCL3 | uniprot | |
| PML | uniprot | |
| IQGAP2 | uniprot | |
| DDX3 | uniprot | |
| GLG1 | uniprot | |
| USP11 | uniprot | |
| BCL7A | uniprot | |
| GSK3B | uniprot | |
| SMARCB1 | uniprot | |
| TRAF1 | uniprot | |
| TBK1 | enzyme | uniprot |
| SMARCE1 | uniprot | |
| COPS3 | uniprot | |
| HDAC6 | uniprot | |
| SMARCC2 | uniprot | |
| UNC5CL | ||
| PKN1 | uniprot | |
| KPNA2 | uniprot | |
| KPNA6 | uniprot | |
| TAB3 | uniprot | |
| PIAS3 | uniprot | |
| PEG3 | uniprot | |
| CAV1 | uniprot | |
| GTF2I | uniprot | |
| TXLNA | uniprot | |
| MAP3K3 | uniprot | |
| YWHAG | uniprot | |
| GAB1 | uniprot | |
| PFDN2 | uniprot | |
| YWHAB | uniprot | |
| YWHAE | uniprot | |
| YWHAH | uniprot | |
| YWHAQ | uniprot | |
| YWHAZ | uniprot | |
| TNFAIP3 | uniprot | |
| TNIP1 | uniprot | |
| TNIP2 | ||
| AKT2 | uniprot | |
| CHUK | enzyme | uniprot |
| AKT1 | uniprot | |
| SRC | uniprot | |
| RNF25 | uniprot | |
| NFKB1 | uniprot | |
| RELA | uniprot | |
| FBXW11 | uniprot | |
| CSNK2A1 | uniprot | |
| CSNK2A2 | uniprot | |
| CSNK2B | uniprot | |
| RIPK1 | uniprot | |
| CASP10 | uniprot | |
| CASP8 | uniprot | |
| TRAF3 | uniprot | |
| BIRC2 | uniprot | |
| BIRC3 | uniprot | |
| PTK2 | uniprot | |
| CFLAR | uniprot | |
| CASP3 | uniprot | |
| NFKBIA | uniprot | |
| CUL1 | uniprot | |
| SKP1A | uniprot | |
| BTRC | uniprot | |
| G3BP2 | uniprot | |
| RELA | uniprot | |
| ASE1 | uniprot | |
| NFKBIB | uniprot | |
| LRPPRC | uniprot | |
| MCC | ||
| MTIF2 | uniprot | |
| NKIRAS1 | uniprot | |
| NKIRAS2 | uniprot | |
| PDCD2 | uniprot | |
| POLR1A | uniprot | |
| POLR1B | uniprot | |
| POLR1D | uniprot | |
| POLRY2H | ||
| POLR2L | uniprot | |
| IKBKB | enzyme | uniprot |
| DBC1 | uniprot | |
| IKBKG | uniprot | |
| CHUK | enzyme | uniprot |
| RASAL2 | uniprot | |
| PRAF1 | uniprot | |
| POLR1C | uniprot | |
| NFKBIE | uniprot | |
| NFKBIA | uniprot | |
| COMMD1 | uniprot | |
| MCM5 | uniprot | |
| MCM7 | uniprot | |
| SUMO1 | uniprot | |
| IKBKAP | uniprot | |
| HSP90AB1 | uniprot | |
| ZA20D2 | uniprot | |
| CREBBP | uniprot | |
| FKBP5 | uniprot | |
| HSP90AA1 | uniprot | |
| PTPN11 | uniprot | |
| MAP3K14 | uniprot | |
| FBL | uniprot | |
| RPL4 | uniprot | |
| KTN1 | uniprot | |
| RPL8 | uniprot | |
| RPS11 | uniprot | |
| RPS13 | uniprot | |
| TRAF5 | uniprot | |
| AZI2 | ||
| IKBKE | uniprot | |
| TANK | uniprot | |
| MAP3K1 | uniprot | |
| WDR68 | uniprot | |
| UBE2I | uniprot | |
| MAP3K8 | uniprot | |
| MAP3K3 | uniprot | |
| MAP2K5 | uniprot | |
| MARK2 | uniprot | |
| RPS6KA5 | uniprot | |
| NFKBIZ | ||
| USP2 | uniprot | |
| NSMAF | uniprot | |
| GNB2L1 | uniprot | |
| NALP4 | uniprot | |
| CRADD | uniprot | |
| CASP2 | uniprot | |
| TNFRSF11A | uniprot | |
| AKAP8 | uniprot | |
| ACTL6A | uniprot | |
| PPP1R13L | uniprot | |
| DPF2 | uniprot | |
| RIPK3 | uniprot | |
| RIPK2 | uniprot | |
| PEBP1 | uniprot | |
| NR2C2 | uniprot | |
| NR2C2 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7IP2 | uniprot | |
| ALPL | uniprot | |
| TNFRSF1A | uniprot | |
| TNF | uniprot | |
| DAP | uniprot | |
| FANCD2 | uniprot | |
| BIRC2 | uniprot | |
| TRAF2 | uniprot | |
| RIPK1 | uniprot | |
| TRADD | uniprot | |
| TNFRSF1B | uniprot | |
| BIRC3 | uniprot | |
| TRAF1 | uniprot | |
| TRAF2 | uniprot | |
| BAG4 | uniprot | |
| RPS6KB1 | uniprot | |
| TRAF4 | uniprot | |
| RELB | uniprot | |
| RELA | uniprot | |
| REL | uniprot | |
| TRAF4 | uniprot | |
| NFKB1 | uniprot | |
| Gene Symbol | ||
| Gene | ||
| Gene | ||
| Gene | ||
| Gene | ||
| NU | ||
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| CY | ||
| EC | ||
| EN | ||
| ER | ||
| GO | ||
| MT | ||
| PM | ||
| Phosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Ubiquitination | ||
| Inhibition | chemical | |
| Sumoylation | chemical | |
| Desumoylation | ||
| Deubiquitination | ||
| Activation | chemical | |
| Recruitment | ||
| Control | ||
| Translocation | ||
| Cytoplasm | ||
| Extracellular | ||
| Endosome | ||
| Endoplasmic reticulum | ||
| Golgi apparatus | ||
| CY ->NU | ||
| CY ->NU | ||
| CY ->NU | ||
| CY ->NU | ||
| CY ->NU | ||
| Receptor | ||
| Ligand | ||
| Proteins in a complex interaction | ||
| Enzyme complex | ||
| Molecular association | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| D | ||
| Autophosphorylation | chemical | |
| Mitochondrion | ||
| Nucleus | CHEBI:33252 | |
| Plasma membrane | ||
| Accession Number: NetPath_9; cellmap:9 | ||
| Molecule in the pathway |
| EIF2B1 | uniprot | |
| EIF2B2 | uniprot | |
| EIF2B3 | uniprot | |
| EIF2B4 | uniprot | |
| EIF2B5 | uniprot | |
| EIF2AK3 | uniprot | |
| EIF2AK2 | uniprot | |
| EIF3S1 | uniprot | |
| EIF3S2 | uniprot | |
| EIF3S3 | uniprot | |
| EIF3S4 | uniprot | |
| EIF3S5 | uniprot | |
| EIF3S6 | uniprot | |
| EIF3S7 | uniprot | |
| EIF3S8 | uniprot | |
| EIF4A1 | uniprot | |
| EIF4A2 | uniprot | |
| EIF4B | uniprot | |
| WBSCR1 | uniprot | |
| EIF4E | uniprot | |
| SUI1 | uniprot | |
| SUI1 | uniprot | |
| PAIP1 | uniprot | |
| EIF4EBP1 | uniprot | |
| EIF4EBP2 | uniprot | |
| EIF4EBP3 | uniprot | |
| EEF1A2 | uniprot | |
| EEF1B2 | uniprot | |
| EEF1D | uniprot | |
| EEF1G | uniprot | |
| EEF2 | uniprot | |
| ETF1 | uniprot | |
| GSPT2 | ||
| PABPC1 | uniprot | |
| EIF4G1 | uniprot | |
| EIF4G3 | uniprot | |
| EIF2S1 | uniprot | |
| EIF2S2 | uniprot | |
| EIF2S3 | uniprot | |
| EIF5B | uniprot | |
| EIF1AY | uniprot | |
| EIF1AX | uniprot | |
| KIAA0664 | uniprot | |
| EIF3S10 | uniprot | |
| EIF3S9 | uniprot | |
| EIF2AK1 | uniprot | |
| EIF5 | uniprot | |
| EIF5A | uniprot | |
| EEF2K | enzyme | uniprot |
| ITGB4BP | uniprot | |
| EEF1A1 | uniprot | |
| AAAAAAAAAAAAAAA | ||
| m7G | ||
| AUG | ||
| mRNA | CHEBI:33699 | |
| Guanine Nucleotide Exchange | ||
| scanning | ||
| 40S Subunit | ||
| Termination | chemical | |
| Elongation | ||
| Initiation | chemical | |
| 60S Subunit | ||
| Binds aminoacyl-tRNA | ||
| Translocation | ||
| Recruitment of 60S subunit | ||
| Recruitment of 43S | ||
| Pre-initiation Complex | ||
| 43S Pre-initiation Complex | ||
| and first peptide bond | ||
| Cap Binding Complex |
| GPD1 | uniprot | |
| GK | ||
| GPAM | uniprot | |
| GNPAT | uniprot | |
| AGPS | uniprot | |
| AYR1 | uniprot | |
| AGPAT1 | uniprot | |
| AGPAT2 | uniprot | |
| AGPAT3 | uniprot | |
| AGPAT4 | uniprot | |
| AGPAT5 | uniprot | |
| PPAP2A | uniprot | |
| PPAP2B | uniprot | |
| PPAP2C | uniprot | |
| DGAT1 | uniprot | |
| GK2 | enzyme | uniprot |
| DGAT2 | uniprot | |
| MGAT1 | uniprot | |
| MGAT2 | uniprot | |
| LPL | enzyme | uniprot |
| LIPE | uniprot | |
| LIPC | uniprot | |
| LIPF | uniprot | |
| PNPLA2 | ||
| MGAT3 | uniprot | |
| Dihydroxyacetonephosphate | hmdbid:HMDB01473 | |
| Glycerol | hmdbid:HMDB00131 | |
| Glycerol-3-phosphate | hmdbid:HMDB00126 | |
| Fatty Acyl CoA | ||
| See Fatty Acid Synthesis MAPP | ||
| Lysophosphatic Acid | chemical | |
| Dihydroxyacetone phosphate | hmdbid:HMDB01473 | |
| Fatty acyl CoA | ||
| acyldihydroxyacetonephosphate | chemical | |
| See Fatty Acid Synthesis MAPP | ||
| Phosphatic acid | chemical | |
| Only 1 of these enzymes is needed | ||
| Diacylglycerol | CHEBI:18035 CHEBI:18035 | |
| Only 1 of these enzymes is needed | ||
| Triacylglycerol | chemical | |
| Fatty Acyl CoA | ||
| Monoacylglycerol | CHEBI:17408 CHEBI:17408 | |
| Degradation | ||
| Path |
| 2.6.1.27 | ||
| 1.4.3.2 | ||
| INDO | uniprot | |
| CYP2J2 | uniprot | |
| ASMT | uniprot | |
| HRMT1L2 | uniprot | |
| AANAT | enzyme | uniprot |
| INDO | uniprot | |
| MDM2 | uniprot | |
| MAOB | uniprot | |
| DDC | uniprot | |
| 2.6.1.27 | ||
| DDC | uniprot | |
| INDO | uniprot | |
| 2.6.1.27 | ||
| 1.13.11.17 | ||
| 1.7.3.2 | ||
| 1.14.16.- | ||
| 3.5.1.49 | ||
| 3.5.1.9 | ||
| 1.13.11.23 | ||
| 1.14.16.3 | ||
| ACAT1 | uniprot | |
| HADH2 | uniprot | |
| ECHS1 | uniprot | |
| GCDH | uniprot | |
| OGDH | uniprot | |
| 1.2.1.32 | ||
| ACMSD | uniprot | |
| HAAO | uniprot | |
| KYNU | uniprot | |
| 1.14.13.9 | ||
| KYNU | uniprot | |
| KYNU | uniprot | |
| TDO2 | uniprot | |
| 4.1.99.1 | ||
| TPH1 | uniprot | |
| WARS | uniprot | |
| 1.13.99.3 | ||
| CAT | uniprot | |
| AADAT | uniprot | |
| AADAT | uniprot | |
| 1.10.3.4 | ||
| MAOB | uniprot | |
| 1.13.11.- | ||
| 1.5.1.- | ||
| DHCR24 | uniprot | |
| 1.13.11.10 | ||
| 1.3.1.18 | ||
| 1.14.99.2 | ||
| 1.13.12.3 | ||
| DDC | uniprot | |
| MAOB | uniprot | |
| 4.1.1.43 | ||
| 1.2.3.7 | ||
| ALDH3A2 | uniprot | |
| 2.1.1.47 | ||
| 1.1.1.110 | ||
| CYP7B1 | uniprot | |
| AFMID | uniprot | |
| ALDH3A2 | uniprot | |
| AOX1 | uniprot | |
| 1.2.1.- | ||
| EDD1 | uniprot | |
| HRMT1L2 | uniprot | |
| HRMT1L2 | uniprot | |
| MAOB | uniprot | |
| 4.2.1.84 | ||
| 3.5.1.4 | ||
| 3.5.5.1 | ||
| 3.2.1.147 | ||
| 1.1.1.190 | ||
| 1.1.1.191 | ||
| ABP1 | uniprot | |
| 2.1.1.49 | ||
| INMT | uniprot | |
| 3.5.99.5 | ||
| CYP1A1 | uniprot | |
| CYP1A2 | uniprot | |
| CYP2A13 | uniprot | |
| Cyp2a1 | uniprot | |
| Cyp2a2 | uniprot | |
| Cyp2c12 | uniprot | |
| Cyp2d2 | uniprot | |
| CYP2E1 | uniprot | |
| CYP19A1 | uniprot | |
| CYP1B1 | uniprot | |
| CYP3A4 | uniprot | |
| CYP2C18 | uniprot | |
| Cyp2b15 | uniprot | |
| Cyp2c39 | uniprot | |
| CYP2F1 | uniprot | |
| CYP4F12 | uniprot | |
| HADHSC | uniprot | |
| ALDH1A2 | uniprot | |
| ALDH1A1 | uniprot | |
| ALDH2 | uniprot | |
| Aldh1a4 | uniprot | |
| ALDH9A1 | uniprot | |
| ALDH1A2 | uniprot | |
| ALDH1A1 | uniprot | |
| Aldh1a4 | uniprot | |
| ALDH2 | uniprot | |
| ALDH9A1 | uniprot | |
| 4.1.1.- | ||
| MDM2 | uniprot | |
| MDM2 | uniprot | |
| UBE3A | uniprot | |
| UBE3A | uniprot | |
| RNF25 | uniprot | |
| RNF25 | uniprot | |
| ASMT | uniprot | |
| GCDH | uniprot | |
| Nicotinate and nicotinamide metabolism | ||
| PhenylAla, Tyr and Trp biosynthesis | ||
| Glycolysis / Gluconeogenesis | ||
| Benzoate degradation via hydroxylation | ||
| Benzoate degradation via hydroxylation | ||
| 6-Hydroxykynurenate | chemical | |
| 4,6-Dihydroxyquinoline | hmdbid:HMDB04077 | |
| 4-(2-Amino-5-hydroxyphenyl) | chemical | |
| 5-Hydroxykynurenamine | CHEBI:28715 | |
| 5-Hydroxykynurenine | CHEBI:2076 | |
| 5-Hydroxy-N-formylkynurenine | CHEBI:2065 | |
| N-Acetylisatin | CHEBI:16050 | |
| N-Acetylindoxyl | CHEBI:15363 | |
| Indoxyl | hmdbid:HMDB04094 | |
| 2,3-Dihydroxyindole | CHEBI:17828 | |
| 2-Oxoglutarate | hmdbid:HMDB00208 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| 5-(2’-Carboxyethyl)-4,6-dihydroxypicolinate | chemical | |
| 5-(2’-Formylethyl)-4,6-dihydroxypicolinate | chemical | |
| 5-(3’-Carboxy-3’-oxopropyl) | chemical | |
| 5-(3’-Carboxy-3’-oxopropenyl)-4,6-dihydroxypicolin | chemical | |
| 7,8-Dihydroxykynurenate | CHEBI:17508 | |
| 7,8-Dihydro-7,8-dihydroxykynurenate | CHEBI:17109 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Kynurenate | hmdbid:HMDB00715 | |
| 4-(2-Aminophenyl)-2,4-dioxobutanoate | hmdbid:HMDB00978 | |
| L-Kynurenine | hmdbid:HMDB00183 | |
| Formylkynurenine | hmdbid:HMDB01200 | |
| Indole | hmdbid:HMDB00738 | |
| 2-Formylaminobenzaldehyde | CHEBI:18033 | |
| 3-Indoleglycolaldehyde | CHEBI:15976 | |
| Indole-3-acetamide | CHEBI:16031 | |
| 5-Hydroxyindolepyruvate | CHEBI:27597 | |
| 5-Hydroxy | chemical | |
| L-Tryptophan | hmdbid:HMDB00929 | |
| C00332 | ||
| C01144 | ||
| C00877 | ||
| C00527 | ||
| 2-Oxoadipate | hmdbid:HMDB00225 | |
| 2-Aminomuconate | hmdbid:HMDB01241 | |
| 2-Aminomuconate | hmdbid:HMDB01241 | |
| Quinolinate | hmdbid:HMDB00232 | |
| 2-Amino-3-carboxymuconate | chemical | |
| 3-Hydroxyanthranilate | hmdbid:HMDB01476 | |
| Xanthurenic | chemical | |
| 4-(2-Amino-3-hydroxyphenyl) | chemical | |
| 4,8-Dihydroxyquinoline | CHEBI:28883 | |
| 3-Hydroxykynurenamine | CHEBI:27421 | |
| 3-Hydroxy- | chemical | |
| Isophenoxazine | CHEBI:17293 | |
| 2-Aminophenol | CHEBI:18112 | |
| Cinnavalininate | chemical | |
| L-Tryptophanyl-tRNA | chemical | |
| 3-(2-Aminoethyl) | chemical | |
| 5-Hydroxyindoleacetaldehyde | hmdbid:HMDB04073 | |
| 5-Hydroxyindoleacetate | hmdbid:HMDB00763 | |
| 5-Methoxytryptamine | hmdbid:HMDB04095 | |
| Formyl-5-hydroxykynurenamine | CHEBI:28736 | |
| N-Acetylserotonin | hmdbid:HMDB01238 | |
| Melatonin | hmdbid:HMDB01389 | |
| 6-Hydroxymelatonin | hmdbid:HMDB04081 | |
| Formyl-N-acetyl-5- | chemical | |
| Indolepyruvate | CHEBI:17640 | |
| Indolelactate | hmdbid:HMDB00671 | |
| 3-Methylindolepyruvate | CHEBI:28549 | |
| 6-Hydroxyindolelactate | CHEBI:27524 | |
| Indole-3-acetate | hmdbid:HMDB00197 | |
| Indole-3-acetaldehyde | hmdbid:HMDB01190 | |
| Tryptamine | hmdbid:HMDB00303 | |
| 5-Methoxyindoleacetate | hmdbid:HMDB04096 | |
| 5-Hydroxyindoleacetylglycine | CHEBI:27631 | |
| Indole-3-ethanol | hmdbid:HMDB03447 | |
| 3-Methyldioxyindole | hmdbid:HMDB04186 | |
| 2-Formamino | chemical | |
| Indole-3-acetaldoxime | CHEBI:28311 | |
| Glucobrassicin | CHEBI:29028 | |
| 3-Methoxyanthranilate | CHEBI:20109 | |
| 8-Methoxykynurenate | chemical | |
| Anthranilate | hmdbid:HMDB01123 | |
| Anthranilate | hmdbid:HMDB01123 | |
| 3-Indoleacetonitrile | CHEBI:17566 | |
| Formylanthranilate | hmdbid:HMDB04089 | |
| N-Methylserotonin | hmdbid:HMDB04369 | |
| N-Methyltryptamine | hmdbid:HMDB04370 | |
| (Z)-5-Oxohex-2-enedioate | chemical | |
| methoxykynurenamine | chemical | |
| -1H-indol-5-ol | chemical | |
| -L-tryptophan | chemical | |
| -2,4-dioxobutanoate | chemical | |
| benzoylacetate | chemical | |
| -2,4-dioxobutanoate | chemical | |
| -4,6-dihydroxypicolinate | chemical | |
| L-kynurenine | hmdbid:HMDB00183 |
| HADHA | uniprot | ||
| HADHB | uniprot | ||
| ACADL | uniprot | ||
| ACADL | uniprot | ||
| HADHA | uniprot | ||
| HADHB | uniprot | ||
| ACADM | uniprot | ||
| DECR1 | uniprot | ||
| DCI | uniprot | ||
| DCI | uniprot | ||
| Linoleoyl-CoA | hmdbid:HMDB01064 | ||
| cis,cis-3,6-Dodecadienoyl-CoA | CHEBI:28002 | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot | |
| trans,cis-Lauro-2,6-dienoyl-CoA | CHEBI:28387 | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot | |
| 4-cis-dexeboyl-CoA | chemical | ||
| 2-trans-4-cis-decadienoyl-CoA | CHEBI:29119 | ||
| 3-trans-decenoyl-CoA | CHEBI:29126 | ||
| trans-dec-2-enoyl-CoA | CHEBI:10723 | ||
| See Beta Oxidation 2 MAPP |
| CPS1 | uniprot | |
| GLUD1 | uniprot | |
| NAGS | uniprot | |
| ALDH18A1 | uniprot | |
| 2.7.2.8 | ||
| 2.6.1.11 | ||
| 1.2.1.38 | ||
| ALDH18A1 | uniprot | |
| 2.3.1.35 | ||
| OTC | enzyme | uniprot |
| ASS | uniprot | |
| OAT | uniprot | |
| PYCR1 | uniprot | |
| ARG1 | uniprot | |
| ODC1 | uniprot | |
| SRM | uniprot | |
| SMS | uniprot | |
| ASL | uniprot | |
| 3.5.1.5 | ||
| 1.2.1.46 | ||
| 1.5.99.1 | ||
| GATM | uniprot | |
| 6.3.4.6 | ||
| 3.5.1.54 | ||
| 3.5.1.59 | ||
| 3.5.2.14 | ||
| 3.5.4.21 | ||
| 3.5.3.3 | ||
| GAMT | uniprot | |
| 3.5.2.10 | ||
| 2.7.3.1 | ||
| CKM | uniprot | |
| 2.6.1.69 | ||
| 3.5.1.16 | ||
| ACY1 | uniprot | |
| ARG2 | uniprot | |
| CKB | uniprot | |
| PYCRL | ||
| SMS | uniprot | |
| Glutamate metabolism | ||
| Ala and aspartate metabolism | ||
| Pyrimidine metabolism | ||
| Pro metabolism | ||
| Nitrogen metabolism | ||
| Amino acid metabolism | ||
| D-Arg and D-ornithine metabolism | ||
| Citrate cycle (TCA cycle) | ||
| Arginine metabolism | ||
| Purine metabolism | ||
| NH3 | CHEBI:16134 | |
| Carbamoyl | CHEBI:33100 | |
| L-Glutamate | hmdbid:HMDB00148 | |
| N-Acetyl-glutamate | hmdbid:HMDB01138 | |
| L-Glutamyl | chemical | |
| N-Acetyl-L-glutamate | hmdbid:HMDB01138 | |
| N2-Acetyl-L-ornithine | CHEBI:16543 | |
| N-Acetyl-L-glutamate | hmdbid:HMDB01138 | |
| L-Aspartate | hmdbid:HMDB00191 | |
| L-Citrulline | hmdbid:HMDB00904 | |
| L-Ornithine | hmdbid:HMDB00214 | |
| (S)-1-Pyrroline-5-carboxylate | hmdbid:HMDB01301 | |
| L-Glutamate- | chemical | |
| L-Proline | hmdbid:HMDB00162 | |
| C03406 | ||
| Spermine | hmdbid:HMDB01256 | |
| Putrescine | hmdbid:HMDB01414 | |
| Spermidine | hmdbid:HMDB01257 | |
| Arginine | hmdbid:HMDB00517 | |
| Fumarate | hmdbid:HMDB00134 | |
| Urea | hmdbid:HMDB00294 | |
| Formate | hmdbid:HMDB00142 | |
| Formaldehyde | hmdbid:HMDB01426 | |
| Urea-1-carboxylate | CHEBI:15832 | |
| CO2 | CHEBI:16526 | |
| Sarcosine | hmdbid:HMDB00271 | |
| N-Methylhydantoin | CHEBI:16354 | |
| N-Carbamoylsarcosine | CHEBI:15737 | |
| Creatine | hmdbid:HMDB00064 | |
| Creatinine | hmdbid:HMDB00562 | |
| Guanidinoacetate | hmdbid:HMDB00128 | |
| creatine-P | hmdbid:HMDB01511 | |
| Phosphoguanidinoacetate | hmdbid:HMDB03705 | |
| 5-semialdehyde | chemical |
| WNT3A | uniprot |
| WNT1 | uniprot |
| WNT2 | uniprot |
| LRP6 | uniprot |
| WNT4 | uniprot |
| SFRP1 | uniprot |
| LRP5 | uniprot |
| AXIN1 | uniprot |
| GSK3B | uniprot |
| LRP6 | uniprot |
| FZD8 | uniprot |
| DKK1 | uniprot |
| DVL1 | uniprot |
| ROR2 | uniprot |
| FZD5 | uniprot |
| WNT7A | uniprot |
| FZD2 | uniprot |
| LRP1 | uniprot |
| WNT5A | uniprot |
| ARRB2 | uniprot |
| PRKCA | uniprot |
| PRKCB1 | uniprot |
| PRKCG | uniprot |
| FZD7 | uniprot |
| MAGI3 | |
| FZD4 | uniprot |
| VANGL2 | uniprot |
| MAPK8 | uniprot |
| MAP3K7 | uniprot |
| HIPK2 | uniprot |
| NLK | uniprot |
| MYB | uniprot |
| FZD1 | uniprot |
| CXXC4 | |
| CSNK1D | uniprot |
| FRAT1 | uniprot |
| TCF3 | uniprot |
| TCF4 | uniprot |
| PIAS4 | uniprot |
| UBL1 | uniprot |
| DVL2 | uniprot |
| RHOA | uniprot |
| DAAM1 | uniprot |
| CSNK1E | uniprot |
| NKD1 | |
| BRD7 | uniprot |
| DAB2 | uniprot |
| CTNNB1 | uniprot |
| EP300 | uniprot |
| FHL2 | uniprot |
| CSNK2A1 | uniprot |
| CSNK2A2 | uniprot |
| CSNK2B | uniprot |
| APC | uniprot |
| CSNK1A1 | uniprot |
| ARRB1 | uniprot |
| CTNNBIP1 | uniprot |
| CDC25C | uniprot |
| CDC2 | uniprot |
| PPP2CA | uniprot |
| DVL3 | uniprot |
| MAP1B | uniprot |
| SF1 | uniprot |
| CTBP1 | uniprot |
| CTBP2 | uniprot |
| PAX2 | uniprot |
| MAPK8IP1 | uniprot |
| TBP | uniprot |
| AXIN2 | uniprot |
| SOX1 | uniprot |
| SALL1 | uniprot |
| AKT1 | uniprot |
| APC | uniprot |
| BCL9 | uniprot |
| PIN1 | uniprot |
| CAMK2A | uniprot |
| CAMK2B | uniprot |
| CAMK2G | uniprot |
| CAMK2D | uniprot |
| JUP | uniprot |
| RAC1 | uniprot |
| SMAD3 | uniprot |
| FZD6 | uniprot |
| CTNNB1 | uniprot |
| SFRP2 | uniprot |
| AXIN1 | uniprot |
| BTRC | uniprot |
| AP2 | uniprot |
| ARRB2 | uniprot |
| RUNX2 | uniprot |
| MARK2 | uniprot |
| CUL1 | uniprot |
| SKP1A | uniprot |
| SMAD4 | uniprot |
| TAX1BP3 | uniprot |
| CDH1 | uniprot |
| RUVBL1 | uniprot |
| FRAT2 | uniprot |
| DLG4 | uniprot |
| DLG2 | uniprot |
| DLG1 | uniprot |
| CTNNB1 | uniprot |
| GSK3B | uniprot |
| DVL1 | uniprot |
| APC | uniprot |
| LEF1 | uniprot |
| LEF1 | uniprot |
| APC | uniprot |
| MAP3K7 | uniprot |
| APC | uniprot |
| CDC2 | uniprot |
| SMT3H2 | uniprot |
| SENP2 | uniprot |
| CSNK2A1 | uniprot |
| CSNK2A2 | uniprot |
| DVL2 | uniprot |
| DVL1 | uniprot |
| BTRC | uniprot |
| CCND1 | uniprot |
| CRYBB2 | uniprot |
| JUN | uniprot |
| MAPK9 | uniprot |
| FZD4 | uniprot |
| FZD1 | uniprot |
| ANKRD6 | uniprot |
| AXIN1 | uniprot |
| SOX9 | uniprot |
| WNT1 | uniprot |
| WNT2 | uniprot |
| WNT1 | uniprot |
| WNT3A | uniprot |
| MAPK3 | uniprot |
| MAPK1 | uniprot |
| RAF1 | uniprot |
| WNT4 | uniprot |
| AKT1 | uniprot |
| FZD1 | uniprot |
| FZD1 | uniprot |
| FZD9 | uniprot |
| WNT1 | uniprot |
| WNT1 | uniprot |
| WNT3 | uniprot |
| Molecular Association | |
| Translocation | |
| Phosphorylation | chemical |
| Autophosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Activation | chemical |
| Inhibition | chemical |
| Acetylation | chemical |
| Ubiquitination | |
| Dephosphorylation | chemical |
| Plasma membrane | |
| PM | |
| Cytoplasm | |
| CY | |
| MT | |
| Nucleus | CHEBI:33252 |
| CY->NU | |
| CY->NU | |
| NU->CY | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| D | |
| PM->CY | |
| D | |
| D | |
| D | |
| CY->PM | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme Complex | |
| (Protein-protein interaction) | |
| Reaction through unknowm mechanisms/molecules | |
| D | |
| Accession Number: NetPath_8; cellmap:8 | |
| Demethylation | chemical |
| Methylation | chemical |
| Palmitoylation | chemical |
| Glycosylation | |
| Deacetylation | chemical |
| Golgi apparatus | |
| Endoplasmic reticulum | |
| Complex formation | |
| Deubiquitination | |
| Control | |
| Recruitment | |
| Proteolytic cleavage | |
| Extracellular | |
| Mitochondrion | |
| Endosome | |
| EN | |
| EC | |
| NU | |
| ER | |
| GO | |
| D | |
| D | |
| D | |
| D |
| TCF-1/LEF | ||
| LDLR | uniprot | |
| WNT1 | uniprot | |
| WNT2 | uniprot | |
| WNT2B | uniprot | |
| WNT3 | uniprot | |
| WNT3A | uniprot | |
| WNT4 | uniprot | |
| WNT5A | uniprot | |
| WNT5B | uniprot | |
| WNT6 | uniprot | |
| WNT7A | uniprot | |
| WNT7B | uniprot | |
| WNT10A | uniprot | |
| WNT10B | uniprot | |
| WNT11 | uniprot | |
| WNT16 | uniprot | |
| WNT16 | uniprot | |
| FZD1 | uniprot | |
| FZD2 | uniprot | |
| FZD10 | uniprot | |
| FZD9 | uniprot | |
| FZD8 | uniprot | |
| FZD7 | uniprot | |
| FZD6 | uniprot | |
| FZD5 | uniprot | |
| SFRP4 | uniprot | |
| FZD3 | uniprot | |
| MAPK9 | uniprot | |
| MAPK10 | uniprot | |
| RHOA | uniprot | |
| RAC1 | uniprot | |
| DVL1 | uniprot | |
| DVL2 | uniprot | |
| DVL3 | uniprot | |
| PRKCB1 | uniprot | |
| PRKCG | uniprot | |
| PRKCD | uniprot | |
| PRKCE | uniprot | |
| PRKCI | uniprot | |
| PRKCH | uniprot | |
| PRKD1 | uniprot | |
| PRKCQ | uniprot | |
| PRKCZ | uniprot | |
| PPP2R5E | uniprot | |
| PPP2R5C | uniprot | |
| FRAT1 | uniprot | |
| AXIN1 | uniprot | |
| CSNK1E | uniprot | |
| GSK3B | uniprot | |
| APC | uniprot | |
| CTNNB1 | uniprot | |
| FBXW2 | uniprot | |
| PAFAH1B1 | uniprot | |
| MYC | uniprot | |
| CCND1 | uniprot | |
| CCND2 | uniprot | |
| CCND3 | uniprot | |
| FOSL1 | uniprot | |
| JUN | uniprot | |
| PLAU | uniprot | |
| PRKCA | uniprot | |
| Apoptosis | ||
| Cytoskeleton | ||
| Phosphorylated | chemical | |
| B | ||
| -Catenin | chemical | |
| P | ||
| Nucleus | CHEBI:33252 | |
| Transcriptional Activation | ||
| -Catenin | chemical | |
| B | ||
| Recruitment to Unknown | ||
| Ubiquitin Conjugating Enzyme | enzyme | |
| Ubiquitin Tagged | ||
| 26S Proteasome Degredation | ||
| Frizzled Ligands |
| Agt | uniprot |
| Ren1 | uniprot |
| Angiotensin I | uniprot |
| Ace | |
| ACE Inhibitor | CHEBI:35457 |
| Kng1 | uniprot |
| Bradykinin | uniprot |
| Ace | |
| Nos3 | uniprot |
| Angiotensin II | uniprot |
| Aldosterone | hmdbid:HMDB00037 |
| Bdkrb2 | uniprot |
| Agtr2 | uniprot |
| Agtr1 | uniprot |
| Cell Membrane |
| Pdha1 | uniprot | |
| Pdha2 | uniprot | |
| Pemt | uniprot | |
| Chat | ||
| Ache | ||
| Chka | uniprot | |
| Pcyt1a | uniprot | |
| Phosphatidylethanolamine | chemical | |
| Phosphatidylcholine | hmdbid:HMDB02357 | |
| Glycerophosphocholine | hmdbid:HMDB00086 | |
| Choline | hmdbid:HMDB00097 | |
| Acetyl CoA | hmdbid:HMDB01206 | uniprot |
| Pyruvate from Glycolysis | ||
| Acetate | hmdbid:HMDB00042 | |
| Choline | hmdbid:HMDB00097 | |
| Phosphorylcholine | hmdbid:HMDB01565 | |
| Cytidine Diphosphate Choline | hmdbid:HMDB01413 | |
| Acetylcholine | hmdbid:HMDB00895 | |
| *Cytosol* | chemical | |
| *Synaptic Cleft* |
| Igf1 | uniprot |
| Ptgis | uniprot |
| Ppard | uniprot |
| Creb1 | uniprot |
| Mixl1 | |
| Gh | |
| Id3 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Nr3c1 | uniprot |
| Ddit3 | uniprot |
| Lif | uniprot |
| Cebpb | uniprot |
| Cyp26a1 | uniprot |
| Cyp26b1 | uniprot |
| Rxra | uniprot |
| Rara | uniprot |
| Nr1h3 | uniprot |
| Lpl | uniprot |
| Fas | uniprot |
| Rbl1 | uniprot |
| Gata3 | uniprot |
| Gata2 | uniprot |
| Pparg | uniprot |
| Tnf | uniprot |
| Mif | uniprot |
| Tgfb1 | uniprot |
| Serpine1 | uniprot |
| Slc2a4 | uniprot |
| Scd1 | uniprot |
| Twist1 | uniprot |
| Fabp4 | uniprot |
| Rb1 | uniprot |
| Rbl2 | uniprot |
| Nsg1 | uniprot |
| E2f1 | uniprot |
| Sp1 | uniprot |
| Hmga1 | uniprot |
| Il6 | uniprot |
| Gadd45a | uniprot |
| Gadd45b | uniprot |
| Cebpa | uniprot |
| Cebpd | uniprot |
| Bmp1 | uniprot |
| Bmp2 | uniprot |
| Bmp3 | uniprot |
| Bmp4 | uniprot |
| E2f4 | |
| Foxo1 | uniprot |
| Klf5 | uniprot |
| Foxc2 | uniprot |
| Ppargc1a | uniprot |
| Ncoa2 | uniprot |
| Ppara | uniprot |
| Stat3 | uniprot |
| Stat2 | uniprot |
| Stat1 | uniprot |
| Stat6 | uniprot |
| Socs1 | uniprot |
| Socs3 | uniprot |
| Cntfr | uniprot |
| Lifr | uniprot |
| Il6st | uniprot |
| Ucp1 | uniprot |
| Wnt1 | uniprot |
| Smad3 | uniprot |
| Fzd1 | uniprot |
| Dvl1 | uniprot |
| Tcf1 | uniprot |
| Rxrg | uniprot |
| Frzb | uniprot |
| Ins1 | uniprot |
| Ins2 | uniprot |
| Trib3 | uniprot |
| Prlr | uniprot |
| Cugbp1 | uniprot |
| Hif1a | uniprot |
| Klf6 | uniprot |
| Klf7 | uniprot |
| Sfrp4 | uniprot |
| Ncor1 | uniprot |
| Ncor2 | uniprot |
| Ahr | uniprot |
| Klf15 | uniprot |
| Egr2 | uniprot |
| Ebf1 | uniprot |
| Epas1 | uniprot |
| Wwtr1 | uniprot |
| Gdf10 | uniprot |
| Irs1 | uniprot |
| LOC384783 | |
| Irs3 | chemical |
| Irs4 | chemical |
| Bscl2 | uniprot |
| Lmna | uniprot |
| Zmpste24 | uniprot |
| Lpin1 | uniprot |
| Lpin2 | uniprot |
| Lpin3 | uniprot |
| Pck1 | uniprot |
| Pck2 | uniprot |
| Dlk1 | uniprot |
| Ndn | uniprot |
| Wnt10b | uniprot |
| Wnt5b | uniprot |
| Gata4 | uniprot |
| Ncoa1 | uniprot |
| Nr2f1 | uniprot |
| Rora | uniprot |
| Nrip1 | uniprot |
| Plin | uniprot |
| Lipe | uniprot |
| Retn | uniprot |
| Adn | uniprot |
| Adfp | uniprot |
| Adpn | uniprot |
| Agt | uniprot |
| Pbef1 | uniprot |
| Spock1 | uniprot |
| Osm | uniprot |
| Catnb | uniprot |
| Agrp | uniprot |
| D10Ertd214e | uniprot |
| Lep | uniprot |
| Mef2a | uniprot |
| Mef2b | uniprot |
| Mef2c | uniprot |
| Mef2d | uniprot |
| Srebf1 | uniprot |
| Mbnl1 | uniprot |
| Adipoq | uniprot |
| Agpat2 | uniprot |
| Inhibitors of Preadipocyte to Adipocyte Transition | |
| Transcription Factors/Modulators | |
| Growth Factors/Hormones | |
| Fully Differentiated Adipocyte Markers | |
| Miscellaneous | |
| Preadipocyte | |
| Differentiated adipocyte | |
| Adipocyte Secretory Products | |
| Possible Lipodystrophy Genes | |
| Insulin Action Genes |
| Pcx | uniprot | |
| 2.3.1.7 | ||
| 2.6.1.18 | ||
| Abat | uniprot | |
| 6.3.2.11 | ||
| 3.4.13.3 | ||
| 4.1.1.11 | ||
| 4.1.1.12 | ||
| Gad2 | uniprot | |
| 2.6.1.12 | ||
| Dars | uniprot | |
| Gpt1 | uniprot | |
| Agxt | uniprot | |
| 6.1.1.7 | ||
| 5.1.1.1 | ||
| 6.3.4.4 | ||
| Ass1 | uniprot | |
| 3.5.1.1 | ||
| 3.5.1.38 | ||
| 6.3.1.1 | ||
| 6.3.5.4 | ||
| 4.3.1.1 | ||
| Asl | uniprot | |
| 4.3.2.2 | ||
| 2.6.1.14 | ||
| 3.5.1.3 | ||
| 1.4.3.2 | ||
| 1.4.3.16 | ||
| 1.2.1.18 | ||
| 2.1.3.2 | ||
| Got2 | uniprot | |
| 6.3.5.6 | ||
| Dars | uniprot | |
| 6.1.1.22 | ||
| 1.4.3.1 | ||
| 1.4.3.15 | ||
| 3.5.1.7 | ||
| 5.1.1.13 | ||
| Aspa | uniprot | |
| Gad1 | uniprot | |
| Got1 | uniprot | |
| Glycolysis / Gluconeogenesis | ||
| Pyrimidine metabolism | ||
| Pantothenate and CoA biosynthesis | ||
| Fatty acid metabolism | ||
| Nicotinate and nicotinamide metabolism | ||
| Reductive carboxylate | chemical | |
| Citrate cycle (TCA cycle) | ||
| Reductive carboxylate cycle (CO2 fixation) | ||
| His metabolism | ||
| Nicotinate and nicotinamide metabolism | ||
| Gly, Ser and Thr metabolism | ||
| Lys biosynthesis | ||
| Urea cycle and metabolism of amino groups | ||
| Arg and Pro metabolism | ||
| beta-Ala metabolism | ||
| Selenoamino acid metabolism | ||
| Cyanoamino acid metabolism | ||
| D-Ala metabolism | ||
| Pyruvate | hmdbid:HMDB00243 | |
| O-Acetylcarnitine | hmdbid:HMDB00201 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Carnosine | hmdbid:HMDB00033 | |
| Malonate semialdehyde | hmdbid:HMDB03015 | |
| L-Alanyl-tRNA | CHEBI:17732 | |
| Protein | CHEBI:16541 | |
| D-Alanine | CHEBI:15570 | |
| L-Aspartyl-tRNA(Asp) | CHEBI:29158 | |
| N-Carbamoyl-L-aspartate | CHEBI:15859 | |
| L-Aspartate | hmdbid:HMDB00191 | |
| L-Argininosuccinate | hmdbid:HMDB00052 | |
| Adenylosuccinate | hmdbid:HMDB00536 | |
| L-Asparagine | hmdbid:HMDB00168 | |
| Citrate | hmdbid:HMDB00094 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| 2-Oxosuccinamate | CHEBI:16327 | |
| 2-Oxoglutarate | hmdbid:HMDB00208 | |
| Succinate | hmdbid:HMDB00254 | |
| Fumarate | hmdbid:HMDB00134 | |
| Malate | hmdbid:HMDB03256 | |
| L-Aspartyl- | chemical | |
| L-Asparaginyl-tRNA(Asn) | CHEBI:29265 | |
| D-Aspartate | CHEBI:29994 | |
| N-Acetyl-L-aspartate | CHEBI:16953 | |
| cycle (CO2 fixation) | ||
| tRNA(Asn) | CHEBI:29172 | |
| b-Alanine | hmdbid:HMDB00056 | |
| L-Alanine | hmdbid:HMDB00161 |
| Rhoa | uniprot |
| Rtkn | uniprot |
| Itgb4 | uniprot |
| Fyn | uniprot |
| Clca3 | |
| Ptk2 | uniprot |
| Itga6 | uniprot |
| Rpsa | uniprot |
| Vim | uniprot |
| Clca5 | |
| Grb2 | uniprot |
| DST | uniprot |
| Erbb2ip | uniprot |
| Erbb2 | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Pik3r3 | uniprot |
| Pik3ca | uniprot |
| Pik3cb | uniprot |
| Pik3cg | uniprot |
| Pik3cd | uniprot |
| Col17a1 | uniprot |
| Shc1 | uniprot |
| Mst1r | uniprot |
| Sfn | uniprot |
| Lama1 | uniprot |
| Lamb1-1 | uniprot |
| Lamc1 | uniprot |
| Lama5 | uniprot |
| Lamb2 | uniprot |
| Lama2 | uniprot |
| Lamc1 | uniprot |
| Lamb1-1 | uniprot |
| Lama5 | uniprot |
| Lamc1 | uniprot |
| Lamc1 | uniprot |
| Lamb1-1 | uniprot |
| Lama2 | uniprot |
| Lama3 | uniprot |
| Lamb3 | uniprot |
| Lamc2 | uniprot |
| Pak1 | uniprot |
| Rac1 | uniprot |
| Plec1 | uniprot |
| Cd151 | uniprot |
| Irs2 | uniprot |
| Irs1 | uniprot |
| Egfr | uniprot |
| Ar | |
| Trp73 | |
| Abl1 | uniprot |
| Ywhab | uniprot |
| Ywhae | uniprot |
| Ywhah | uniprot |
| Ywhaq | uniprot |
| Ywhaz | uniprot |
| Yes1 | uniprot |
| Dsp | |
| Met | |
| Eif4ebp1 | uniprot |
| Eif4e | uniprot |
| Itgb4bp | uniprot |
| Lamc1 | uniprot |
| Lamb2 | uniprot |
| Ntn1 | uniprot |
| Akt1 | uniprot |
| Casp3 | uniprot |
| Bad | |
| Prkca | uniprot |
| Frap1 | uniprot |
| Prkcd | uniprot |
| Mmp7 | uniprot |
| Src | uniprot |
| Rhoa | uniprot |
| Smad2 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| Smad3 | uniprot |
| Itgb4bp | uniprot |
| Cdkn1a | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Laminin 1 | |
| Laminin 2 | |
| Laminin 11 | |
| Laminin 4 | |
| Laminin 10 | |
| CY->PM | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| Molecular Association | |
| Deacetylation | chemical |
| Autophosphorylation | chemical |
| D | |
| Translocation | |
| Plasma membrane | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Inhibition | chemical |
| Ligand | |
| Receptor | |
| Gene Symbol | |
| Molecule in the pathway | |
| Activation | chemical |
| Acetylation | chemical |
| Accession Number: NetPath_1; cellmap:1 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| NU | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Phosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Laminin 5 |
| Ar | |
| HSPA1A | uniprot |
| Stub1 | uniprot |
| Cdc37 | uniprot |
| Cdc25b | uniprot |
| RAS | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Ar | |
| Ar | |
| Ar | |
| Cdk9 | uniprot |
| Ctnnb1 | uniprot |
| Cav1 | uniprot |
| Crebbp | uniprot |
| Hdac1 | uniprot |
| Svil | uniprot |
| Cdk7 | uniprot |
| Ccnh | uniprot |
| Gtf2h1 | uniprot |
| Ctdp1 | uniprot |
| Gtf2f1 | uniprot |
| Gtf2f2 | uniprot |
| Ncoa2 | uniprot |
| Ncoa1 | uniprot |
| Psmc3ip | |
| Nr2c2 | uniprot |
| Ncoa3 | uniprot |
| Fhl2 | uniprot |
| FLNA | uniprot |
| FLNA | uniprot |
| Aes | uniprot |
| Bag1 | uniprot |
| Brca1 | uniprot |
| Ccne1 | uniprot |
| Ccnd1 | uniprot |
| Jun | uniprot |
| Calr | uniprot |
| Cox5b | uniprot |
| Runx2 | uniprot |
| RUNX1 | uniprot |
| Ar | |
| Slc25a4 | uniprot |
| Atf2 | uniprot |
| Tmf1 | |
| NCOA4 | uniprot |
| Tgfb1i1 | |
| Rnf14 | uniprot |
| Ran | |
| Rad54l2 | |
| Pias2 | uniprot |
| Uxt | uniprot |
| Egfr | uniprot |
| Ube3a | uniprot |
| Esr1 | uniprot |
| Pa2g4 | uniprot |
| Etv5 | uniprot |
| Mmp1a | uniprot |
| LOC622339 | |
| Nr3c1 | uniprot |
| Src | uniprot |
| Mapk1 | uniprot |
| Il6st | uniprot |
| Myst2 | uniprot |
| Nsd1 | uniprot |
| Pou2f1 | uniprot |
| Pou2f2 | uniprot |
| Akt1 | uniprot |
| Mdm2 | uniprot |
| PLAGL1 | uniprot |
| Rac3 | uniprot |
| Rb1 | uniprot |
| Rb1 | uniprot |
| Rela | uniprot |
| Ranbp9 | uniprot |
| Nrip1 | uniprot |
| Rnf4 | uniprot |
| Zfp278 | |
| Pxn | uniprot |
| Spdef | uniprot |
| Prmt1 | uniprot |
| Prmt1 | uniprot |
| Pnrc1 | uniprot |
| Pias4 | uniprot |
| Pias1 | uniprot |
| Pias3 | uniprot |
| Stat3 | uniprot |
| Pnrc1 | uniprot |
| Smad3 | uniprot |
| Smad4 | uniprot |
| SRY | uniprot |
| Nr0b2 | uniprot |
| Sp1 | uniprot |
| Ncor2 | uniprot |
| Tgif | uniprot |
| Ube2i | uniprot |
| Sin3a | uniprot |
| Rchy1 | uniprot |
| Rchy1 | uniprot |
| Hipk3 | uniprot |
| Pak6 | |
| Pcaf | chemical |
| Akt1 | uniprot |
| 2900057D21Rik | |
| Htatip | uniprot |
| Ep300 | |
| Senp1 | uniprot |
| Cdc2a | uniprot |
| Mapk1 | uniprot |
| Jun | uniprot |
| Nr3c1 | uniprot |
| Il6 | uniprot |
| Pten | uniprot |
| Esr2 | uniprot |
| Nr0b1 | uniprot |
| Igf1 | uniprot |
| GHBP | uniprot |
| Ghr | uniprot |
| Trp53 | uniprot |
| Casp1 | uniprot |
| Casp3 | uniprot |
| Casp7 | uniprot |
| Casp8 | uniprot |
| Hmgb2 | uniprot |
| Hmgb1 | uniprot |
| Ywhah | uniprot |
| Nr5a1 | uniprot |
| Esr1 | uniprot |
| Androgen (T/DHT) | |
| P | |
| P | |
| P | |
| P | |
| Molecular association | |
| Proteolytic Cleavage | |
| DeSumoylation | |
| Phosphorylation | chemical |
| Activation | chemical |
| Ubiquitination | |
| Translocation | |
| Inhibition | chemical |
| Enzyme complex | |
| Androgen Independent | |
| P | |
| CY | |
| NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| Gene Symbol | |
| Molecule in the pathway | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| D | |
| D | |
| D | |
| D | |
| (Protein-protein interaction) | |
| Reactions through unknown mechanisms/molecules | |
| D | |
| Receptor | |
| Ligand | |
| Proteins in a complex interaction | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Sumoylation | chemical |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| EN | |
| Extracellular | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi appparatus | |
| MT | |
| Mitochondrion | |
| PM | |
| Plasma membrane | |
| Androgen Independent | |
| Accession Number: NetPath_2; cellmap:2 |
| Tradd | chemical |
| Tnfsf10 | uniprot |
| Tnfrsf1a | uniprot |
| Tnf | uniprot |
| Tnfrsf1b | uniprot |
| Traf1 | uniprot |
| Traf2 | uniprot |
| Map3k1 | uniprot |
| Map2k4 | uniprot |
| Mapk10 | uniprot |
| Fadd | uniprot |
| Ripk1 | uniprot |
| Birc2 | uniprot |
| Birc3 | uniprot |
| Birc4 | uniprot |
| Casp6 | uniprot |
| Casp7 | uniprot |
| Casp3 | uniprot |
| Casp2 | uniprot |
| Bcl2 | uniprot |
| Ikbkg | uniprot |
| Bcl2l1 | uniprot |
| Gzmb | uniprot |
| Prf1 | uniprot |
| Fasl | uniprot |
| Bak1 | uniprot |
| Bid | |
| Bax | uniprot |
| Myc | uniprot |
| Trp53 | uniprot |
| Mdm2 | uniprot |
| Rela | uniprot |
| Nfkb1 | uniprot |
| Apaf1 | uniprot |
| Casp9 | |
| Cycs | uniprot |
| Cyct | uniprot |
| Nfkbia | uniprot |
| Jun | uniprot |
| Bcl2l11 | uniprot |
| Bid3 | uniprot |
| Bnip3l | uniprot |
| Casp10 | |
| Dffb | uniprot |
| Dffa | uniprot |
| Hells | uniprot |
| Bad | |
| Casp1 | uniprot |
| Casp11 | uniprot |
| Casp11 | uniprot |
| Casp8 | uniprot |
| Traf3 | uniprot |
| Tnfrsf25 | |
| Lta | uniprot |
| Tnfrsf10b | uniprot |
| Tnfrsf21 | uniprot |
| Ikbkb | uniprot |
| Chuk | uniprot |
| Nfkbib | uniprot |
| Nfkbie | uniprot |
| Nfkbia | uniprot |
| Nfkbib | uniprot |
| Nfkbie | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Birc5 | uniprot |
| Trp73 | |
| Trp63 | uniprot |
| Irf1 | uniprot |
| Irf2 | uniprot |
| Irf3 | uniprot |
| Irf4 | uniprot |
| Irf5 | uniprot |
| Irf6 | uniprot |
| Irf7 | uniprot |
| Bok | uniprot |
| Pmaip1 | chemical |
| Bbc3 | uniprot |
| Bcl2l2 | uniprot |
| Cradd | uniprot |
| Cflar | uniprot |
| Ripk1 | uniprot |
| Tradd | chemical |
| Diablo | uniprot |
| Cdkn2a | uniprot |
| Mcl1 | uniprot |
| Tnfrsf1a | uniprot |
| Bad | |
| Fas | uniprot |
| Pik3r1 | uniprot |
| Akt1 | uniprot |
| Igf1r | uniprot |
| Igf2 | uniprot |
| Igf1 | uniprot |
| Apoptosis | |
| Activator of Cell Death | |
| Inhibitor of Cell Death | |
| Fas Ligand | uniprot |
| DNA Fragmentation | |
| e | |
| e | |
| Mitochondrion | |
| p | |
| p | |
| degredation | |
| b | |
| Casp | uniprot |
| b | |
| p53 Related | |
| Interferon regulatory factors | |
| b | |
| IGF1R signaling pathway |
| Cd79b | uniprot |
| Blk | uniprot |
| Fyn | uniprot |
| Lyn | |
| Syk | uniprot |
| Blnk | uniprot |
| Map4k1 | uniprot |
| Cd5 | uniprot |
| Ptk2 | uniprot |
| Ptpn6 | uniprot |
| Hcls1 | uniprot |
| Was | |
| Actr2 | uniprot |
| Actr3 | uniprot |
| Arpc1b | uniprot |
| Arpc2 | uniprot |
| Arpc3 | uniprot |
| Arpc4 | uniprot |
| Arpc5 | uniprot |
| Hcls1 | uniprot |
| Grb2 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Nck1 | |
| Vav1 | uniprot |
| Plcg1 | uniprot |
| Cr2 | uniprot |
| Cd19 | uniprot |
| Cd81 | uniprot |
| Plcg2 | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Pik3ap1 | |
| Mapk1 | uniprot |
| Elk1 | uniprot |
| Btk | uniprot |
| Cbl | uniprot |
| Shc1 | uniprot |
| Lck | uniprot |
| Bcar1 | uniprot |
| Nedd9 | uniprot |
| Ptk2b | uniprot |
| Hck | uniprot |
| Crkl | uniprot |
| BANK1 | uniprot |
| Itpr2 | uniprot |
| PILRB | uniprot |
| Ptpn11 | uniprot |
| Cd22 | uniprot |
| Casp9 | |
| Casp7 | uniprot |
| Cblb | uniprot |
| Sh3bp2 | uniprot |
| Vav2 | uniprot |
| Prkcm | uniprot |
| Ptpn6 | uniprot |
| Itk | uniprot |
| Tec | uniprot |
| Crk | uniprot |
| Rapgef1 | chemical |
| Lcp2 | uniprot |
| AI586015 | |
| Dok1 | uniprot |
| Ptpn18 | uniprot |
| Pip5k1b | uniprot |
| Pip5k2a | uniprot |
| Pip5k1a | uniprot |
| Pip5k2b | uniprot |
| Pip5k1c | uniprot |
| Pip5k2c | |
| Pip5k1a | uniprot |
| Pip5k2b | uniprot |
| Rps6ka1 | uniprot |
| Mapk3 | uniprot |
| Rasa1 | uniprot |
| Rps6ka1 | uniprot |
| Prkcd | uniprot |
| Prkcd | uniprot |
| Creb1 | uniprot |
| Lat2 | uniprot |
| Pdpk1 | uniprot |
| Akt1 | uniprot |
| Akt1 | uniprot |
| Gsk3a | uniprot |
| Rap2a | uniprot |
| Foxo1 | uniprot |
| Inpp5d | |
| Dok3 | uniprot |
| Mapk8 | uniprot |
| Fcgr2b | uniprot |
| Hcls1 | uniprot |
| RPS6KB1 | uniprot |
| RPS6 | uniprot |
| Gab2 | uniprot |
| Jun | uniprot |
| Atf2 | uniprot |
| Mapk14 | uniprot |
| Bcl6 | uniprot |
| Mapkapk2 | uniprot |
| CDK2 | uniprot |
| Rb1 | uniprot |
| Cdk4 | uniprot |
| Cdk6 | uniprot |
| Ctnnb1 | uniprot |
| Ctnnb1 | uniprot |
| Gsk3b | uniprot |
| Ikbkb | uniprot |
| Chuk | uniprot |
| Nfkbia | uniprot |
| Rela | uniprot |
| Rel | uniprot |
| Rela | uniprot |
| Rel | uniprot |
| Prkcb1 | uniprot |
| Cd72 | uniprot |
| Atp2b4 | uniprot |
| Nfatc2 | uniprot |
| Nfatc3 | uniprot |
| Nfatc2 | uniprot |
| Nfatc3 | uniprot |
| Ppp3ca | uniprot |
| Ppp3cb | uniprot |
| Aps | uniprot |
| Gtf2i | uniprot |
| Plekha1 | uniprot |
| Plekha2 | uniprot |
| Dapp1 | uniprot |
| Plekha2 | uniprot |
| Plekha1 | uniprot |
| Lime1 | uniprot |
| Csk | uniprot |
| Card11 | |
| Bcl10 | uniprot |
| Map3k7 | uniprot |
| Ikbkg | uniprot |
| Ccnd2 | uniprot |
| Ccnd3 | uniprot |
| Ccne1 | uniprot |
| Ccna2 | uniprot |
| Hnrpk | uniprot |
| Ptprc | uniprot |
| Ppp3r1 | uniprot |
| Nfatc1 | uniprot |
| Prkcq | uniprot |
| Cdk7 | uniprot |
| Cd79a | uniprot |
| Dapp1 | uniprot |
| Hdac5 | uniprot |
| Hdac7a | uniprot |
| Hdac5 | uniprot |
| Hdac7a | uniprot |
| Cycs | uniprot |
| Cycs | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Dusp4 | uniprot |
| Dusp6 | uniprot |
| Stat3 | uniprot |
| Stat1 | uniprot |
| Zap70 | uniprot |
| Bcl2l11 | uniprot |
| Mapk4 | uniprot |
| SLA2 | uniprot |
| 4631426J05Rik | |
| Cmtm3 | uniprot |
| Bcl2 | uniprot |
| IGHM | uniprot |
| Prkcb1 | uniprot |
| Rasgrp3 | |
| BRAF | uniprot |
| Pdk2 | uniprot |
| Bax | uniprot |
| Bax | uniprot |
| Rasgrp3 | |
| Gab1 | uniprot |
| Pip5k1a | uniprot |
| Pip5k2b | uniprot |
| Shc1 | uniprot |
| Prkce | uniprot |
| Prkce | uniprot |
| Gtf2i | uniprot |
| Itpr1 | uniprot |
| Pik3ap1 | |
| Card11 | |
| Rapgef1 | chemical |
| Crk | uniprot |
| Btk | uniprot |
| Blnk | uniprot |
| Gab1 | uniprot |
| Ptpn6 | uniprot |
| Plcg2 | uniprot |
| Inpp5d | |
| Chuk | uniprot |
| Ikbkb | uniprot |
| Lyn | |
| Syk | uniprot |
| Cd79a | uniprot |
| Lyn | |
| Syk | uniprot |
| Lat2 | uniprot |
| Rhoa | uniprot |
| Gene Symbol | |
| Pik3cg | uniprot |
| Sos2 | uniprot |
| ARP2/3 | |
| Complex | |
| Molecular association | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Translocation | |
| Ubiquitination | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Mitochondria | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| CY->PM | |
| CY->NU | |
| CY->PM | |
| CY->PM | |
| Autophosphorylation | chemical |
| Plasma membrane | |
| CY->PM | |
| PM->CY | |
| NU->CY | |
| NU->CY | |
| CY->MT | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| D | |
| Receptor | |
| Accesion Number: NetPath_12 | |
| MA | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| CY->NU | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| PM->CY | |
| MT->CY | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme Complex | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| D | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| PM | |
| CY | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| NU | |
| Ligand | |
| D |
| Th | |
| Ddc | uniprot |
| Dbh | uniprot |
| Pnmt | uniprot |
| Pah | uniprot |
| Tph1 | uniprot |
| Ddc | uniprot |
| Asmt | chemical |
| Hdc | uniprot |
| Ddc | uniprot |
| Gad1 | uniprot |
| Gad2 | uniprot |
| Chat | |
| Comt | uniprot |
| Maoa | uniprot |
| Ache | |
| Maoa | uniprot |
| Aanat | uniprot |
| Tyrosine | hmdbid:HMDB00158 |
| L-DOPA | hmdbid:HMDB00181 |
| Dopamine | hmdbid:HMDB00073 |
| Norepinephrine | hmdbid:HMDB00216 |
| Epinephrine | hmdbid:HMDB00068 |
| Phenylalanine | hmdbid:HMDB00159 |
| Tryptophan | hmdbid:HMDB00929 |
| 5-hydroxy-tryptophan | chemical |
| Serotonin | hmdbid:HMDB00259 |
| Acetylserotonin | chemical |
| Melatonin | hmdbid:HMDB01389 |
| Histidine | hmdbid:HMDB00177 |
| Histamine | hmdbid:HMDB00870 |
| Glutamate | hmdbid:HMDB03339 |
| GABA | hmdbid:HMDB00112 |
| Choline | hmdbid:HMDB00097 |
| Acetylcholine | hmdbid:HMDB00895 |
| Synthesis pathways for biogenic amines (in blue) | |
| follow solid arrows through enzymatic steps, | |
| while degradation steps follow dashed arrows. |
| F12 | uniprot | |
| F9 | ||
| F10 | uniprot | |
| Serpine1 | uniprot | |
| Serpinb2 | uniprot | |
| F8 | ||
| F8a | uniprot | |
| Plat | uniprot | |
| F5 | ||
| Fgl2 | uniprot | |
| F2 | ||
| Fga | uniprot | |
| Plau | uniprot | |
| Plg | uniprot | |
| Serpinf2 | uniprot | |
| F13b | uniprot | |
| F10 | uniprot | |
| Vwf | uniprot | |
| F7 | ||
| Factor XIIa | ||
| Factor XIa | ||
| Factor VIIIa | ||
| Factor IXa | ||
| Factor Xa | ||
| Factor Va | ||
| Thrombin | enzyme | uniprot |
| Fibrin Monomer | ||
| Factor XIIIa | ||
| Fibrin Polymer | ||
| Factor VIIa | ||
| + | ||
| + | ||
| Intrinsic Pathway | ||
| Extrinsic Pathway | ||
| Tissue Factor | ||
| Plasmin | enzyme | |
| Fibrin | ||
| Fibrin Split Products | ||
| Thrombolysis | ||
| Tissue Injury |
| Gnas | uniprot | |
| Gnaq | uniprot | |
| Anxa6 | uniprot | |
| Ryr2 | ||
| Fkbp1a | uniprot | |
| Pln | uniprot | |
| Calr | uniprot | |
| Casq2 | uniprot | |
| Adcy7 | uniprot | |
| Rgs2 | uniprot | |
| Rgs20 | uniprot | |
| Ywhah | uniprot | |
| Prkcb1 | uniprot | |
| Ywhaq | uniprot | |
| Ywhag | uniprot | |
| Ywhae | uniprot | |
| Ywhaz | uniprot | |
| Rgs19 | uniprot | |
| Sfn | uniprot | |
| Prkch | uniprot | |
| Prkar2a | uniprot | |
| Adcy8 | uniprot | |
| Adcy6 | uniprot | |
| Prkacb | uniprot | |
| Prkce | uniprot | |
| Prkcz | uniprot | |
| Prkcd | uniprot | |
| Prkcm | uniprot | |
| Adcy9 | uniprot | |
| Prkci | uniprot | |
| Prkcc | uniprot | |
| Prkca | uniprot | |
| Adcy2 | uniprot | |
| Prkar1b | uniprot | |
| Prkcq | uniprot | |
| Rgs4 | uniprot | |
| Rgs17 | uniprot | |
| Rgs16 | uniprot | |
| Rgs14 | uniprot | |
| Rgs11 | uniprot | |
| Rgs10 | uniprot | |
| Rgs9 | uniprot | |
| Rgs7 | uniprot | |
| Prkar2b | uniprot | |
| Rgs5 | uniprot | |
| Prkaca | uniprot | |
| Rgs3 | uniprot | |
| Rgs1 | uniprot | |
| Adcy3 | uniprot | |
| Prkar1a | uniprot | |
| Rgs18 | uniprot | |
| Rgs6 | uniprot | |
| Gng2 | uniprot | |
| Gngt1 | uniprot | |
| Gnb5 | uniprot | |
| Gnb4 | uniprot | |
| Gnb3 | uniprot | |
| Gnb2 | uniprot | |
| Gnb1 | uniprot | |
| Gprk6 | uniprot | |
| Plcb3 | uniprot | |
| Gng4 | uniprot | |
| Gprk2l | uniprot | |
| Gprk5 | uniprot | |
| Pkib | uniprot | |
| Calm2 | uniprot | |
| Pkig | uniprot | |
| Pkia | uniprot | |
| Gng3 | uniprot | |
| Gng11 | uniprot | |
| Gng5 | uniprot | |
| Gng13 | uniprot | |
| Gng12 | uniprot | |
| Gng8 | uniprot | |
| Gng7 | uniprot | |
| Ywhab | uniprot | |
| Plcb3 | uniprot | |
| Arrb2 | uniprot | |
| Arrb1 | uniprot | |
| Calm1 | uniprot | |
| Ryr3 | ||
| Itpr1 | uniprot | |
| Itpr2 | uniprot | |
| Itpr3 | uniprot | |
| Calm3 | uniprot | |
| Gna11 | uniprot | |
| Ryr1 | ||
| Casq1 | uniprot | |
| Atp2a3 | uniprot | |
| Camk2a | uniprot | |
| Camk2b | uniprot | |
| Camk2g | uniprot | |
| Camk2d | uniprot | |
| Camk1 | uniprot | |
| Camk4 | uniprot | |
| Cacnb3 | uniprot | |
| Cacnb1 | uniprot | |
| Atp2b3 | uniprot | |
| Atp2b2 | uniprot | |
| Atp2b1 | uniprot | |
| Slc8a3 | uniprot | |
| Slc8a1 | uniprot | |
| Atp1a4 | uniprot | |
| Atp1b1 | uniprot | |
| Atp1b2 | uniprot | |
| Atp1b3 | uniprot | |
| Fxyd2 | uniprot | |
| Chrm1 | uniprot | |
| Chrm2 | uniprot | |
| Chrm3 | uniprot | |
| Chrm4 | uniprot | |
| Chrm5 | uniprot | |
| Cacna1c | uniprot | |
| Cacna1d | uniprot | |
| Cacna1e | uniprot | |
| Cacna1s | uniprot | |
| Cacna1a | uniprot | |
| Cacna1b | uniprot | |
| Adrb1 | uniprot | |
| Adrb3 | uniprot | |
| Adrb2 | uniprot | |
| Adra1a | uniprot | |
| Adra1b | uniprot | |
| Adra1d | uniprot | |
| Gja1 | uniprot | |
| Gja3 | uniprot | |
| Gja4 | uniprot | |
| Gja5 | uniprot | |
| Gja6 | uniprot | |
| Gja7 | uniprot | |
| Gja8 | uniprot | |
| Gja9 | uniprot | |
| Gja10 | uniprot | |
| Gja12 | uniprot | |
| Gjb1 | uniprot | |
| Gjb2 | uniprot | |
| Gjb3 | uniprot | |
| Gjb4 | uniprot | |
| Gjb5 | uniprot | |
| Gjb6 | uniprot | |
| Kcnj3 | uniprot | |
| Kcnj5 | uniprot | |
| Kcnb1 | uniprot | |
| Gnai1 | uniprot | |
| Gnai2 | uniprot | |
| Gnai3 | uniprot | |
| Gnao1 | uniprot | |
| Gnaz | uniprot | |
| Adcy1 | uniprot | |
| Atp2a2 | uniprot | |
| Adcy5 | uniprot | |
| Adcy4 | uniprot | |
| cAMP | hmdbid:HMDB00058 | |
| Ca2+ | CHEBI:29108 | |
| Na+ | CHEBI:29101 | |
| Na+ | CHEBI:29101 | |
| P | ||
| FKBP12 | uniprot | |
| P | ||
| Ca | ||
| IP3 | ||
| DAG | uniprot | |
| PIP2 | uniprot | |
| SR | ||
| GRK | ||
| Calmodulin | uniprot | |
| PKA Inhibitors | ||
| beta Arrestin | ||
| Protein Kinase A | uniprot | |
| Signaling | ||
| PKC inhibitor Protein-1 | ||
| Adenylyl Cyclases | enzyme | uniprot |
| G | ||
| Regulators of G-protein | ||
| bg | ||
| Protein Kinase C | uniprot | |
| Protein Kinase A | uniprot | |
| Na2+ | ||
| Repolarization | ||
| Cytosolic Ca | chemical | |
| 2+ | ||
| Ca | ||
| 2+ | ||
| Calreticulin-Ca | ||
| Calsequestrin C-Ca | chemical | |
| Calsequestrin S-Ca | chemical | |
| 2+ | ||
| 2+ | ||
| 2+ | ||
| 2+ | ||
| Cytosolic Ca | chemical | |
| ATP | hmdbid:HMDB00538 | |
| ADP + Pi | ||
| Phopholamban | chemical | |
| ADP + Pi | ||
| 2+ | ||
| Cytosolic Ca | chemical | |
| Acetylcholine | hmdbid:HMDB00895 | |
| Epinephrine | hmdbid:HMDB00068 | |
| Epinephrine | hmdbid:HMDB00068 | |
| IP4 | ||
| IP3 Receptors | ||
| Ca | ||
| 2+ | ||
| 2+ | ||
| Cytosol | ||
| CaM kinase | enzyme | |
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| CaM kinase | enzyme | |
| K+ | ||
| Ca | ||
| 2+ | ||
| ATP | hmdbid:HMDB00538 | |
| Dihydropyridine-Sensitive | ||
| Membrane | ||
| Depolarization | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| Na+/Ca2+ Exchanger | ||
| Na+/K+ ATPase | ||
| ATP | hmdbid:HMDB00538 | |
| Adrenergic Receptor | ||
| b | ||
| L-Type Ca2+ Channel | ||
| M1 Muscarinic Receptor | ||
| a | ||
| Adrenergic Receptor | ||
| Cyclases | uniprot | |
| Adenylyl | chemical | |
| G | ||
| b | ||
| G | ||
| g | ||
| G | ||
| bg | ||
| IP3 Receptors | ||
| Connexin | ||
| Connexin | ||
| Gap Junctions (Connexins) | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| b | ||
| arrestin/GRK | ||
| b | ||
| arrestin/GRK | ||
| G alpha i/o/z | ||
| K+ | ||
| K+ | ||
| G | ||
| bg | ||
| G alpha i/o/z |
| Bcmo1 | uniprot | |
| Lrat | uniprot | |
| Retsat | uniprot | |
| Adh1 | uniprot | |
| Adh5 | uniprot | |
| Adh4 | uniprot | |
| Rdh7 | uniprot | |
| Rdh5 | chemical | |
| Dhrs3 | uniprot | |
| Rbp1 | uniprot | |
| Rbp2 | uniprot | |
| Rbp7 | uniprot | |
| Rbp4 | uniprot | |
| Crabp1 | uniprot | |
| Crabp2 | uniprot | |
| Bcdo2 | uniprot | |
| ARAT | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Raldh3 | uniprot | |
| Aldh8a1 | ||
| Cyp26a1 | uniprot | |
| Rdh7 | uniprot | |
| Rdh16 | chemical | |
| Rdh11 | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh8a1 | ||
| RARa | ||
| RARb | ||
| RARg | ||
| RXRa | ||
| RXRb | ||
| RXRg | ||
| Cyp26b1 | uniprot | |
| Cyp2e1 | uniprot | |
| Ugt1a7c | ||
| Sult1a1 | uniprot | |
| Sult2b1 | uniprot | |
| Scarb1 | uniprot | |
| Cd36 | uniprot | |
| Bcmo1 | uniprot | |
| Lrat | uniprot | |
| Lpl | uniprot | |
| Scarb1 | uniprot | |
| Abcg5 | uniprot | |
| Abcg8 | uniprot | |
| Npc1l1 | uniprot | |
| all-trans ROL | ||
| 9-cis ROL | ||
| 13,14 dehydro ROL | ||
| RE | ||
| beta-carotene | hmdbid:HMDB00561 | |
| beta-10'-apocarotenal | chemical | |
| all-trans RAL | ||
| 9-cis RAL | ||
| 13,14 dehydro RAL | ||
| all-trans RA | ||
| 9-cis RA | ||
| 13,14 dehydro RA | ||
| ? | ||
| 5 | ||
| 5 | ||
| 1,2,3 | ||
| 1,2,3,4,6 | ||
| 7,8,9 | ||
| ROL=retinol; RAL=retinaldehyde | ||
| ROL-binding proteins | ||
| RA-binding proteins | ||
| Nucleus | CHEBI:33252 | |
| Nuclear receptors | ||
| all-trans-4-oxo dehydro RA | ||
| Cytochrome P450 family | ||
| all-trans-4-oxo RA | ||
| ? | ||
| PPAR pathways | ||
| RA = retinoic acid, RE = retinyl ester | ||
| beta-carotene | hmdbid:HMDB00561 | |
| Liver | ||
| Enterocyte | ||
| beta-carotene | hmdbid:HMDB00561 | |
| beta-carotene | hmdbid:HMDB00561 | |
| RAL | uniprot | |
| ROL | uniprot | |
| RE | ||
| RE + dietary lipids | ||
| ROL | uniprot | |
| chylomicron | ||
| RE + dietary lipids | ||
| RE + dietary lipids | ||
| ? | ||
| Blood | ||
| ? |
| Bcmo1 | uniprot | |
| Lrat | uniprot | |
| Retsat | uniprot | |
| Adh1 | uniprot | |
| Adh5 | uniprot | |
| Adh4 | uniprot | |
| Rdh7 | uniprot | |
| Rdh5 | chemical | |
| Dhrs3 | uniprot | |
| Rbp1 | uniprot | |
| Rbp2 | uniprot | |
| Rbp7 | uniprot | |
| Rbp4 | uniprot | |
| Crabp1 | uniprot | |
| Crabp2 | uniprot | |
| Scarb1 | uniprot | |
| Bcdo2 | uniprot | |
| ARAT | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Raldh3 | uniprot | |
| Aldh8a1 | ||
| Cyp26a1 | uniprot | |
| Rdh7 | uniprot | |
| Rdh16 | chemical | |
| Rdh11 | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh8a1 | ||
| dietary CAR | ||
| all-trans ROL | ||
| 9-cis ROL | ||
| 13,14 dehydro ROL | ||
| retinyl ester | hmdbid:HMDB03598 | |
| beta-carotene | hmdbid:HMDB00561 | |
| beta-10'-apocarotenal | chemical | |
| all-trans RAL | ||
| 9-cis RAL | ||
| 13,14 dehydro RAL | ||
| all-trans RA | ||
| 9-cis RA | ||
| 13,14 dehydro RA | ||
| ? | ||
| ? | ||
| 5 | ||
| 5 | ||
| 1,2,3 | ||
| 1,2,3,4,6 | ||
| 7,8,9 | ||
| ROL=retinol; RAL=retinaldehyde; RA=retinoic acid | ||
| ROL-binding proteins | ||
| RA-binding proteins | ||
| Nucleus | CHEBI:33252 | |
| RA-receptors | ||
| all-trans-4-oxo dehydro RA | ||
| CYP26 Gene family | ||
| all-trans-4-oxo RA |
| Lrat | uniprot | |
| Rpe65 | uniprot | |
| Rdh5 | chemical | |
| Retsat | uniprot | |
| Adh1 | uniprot | |
| Adh5 | uniprot | |
| Rdh16 | chemical | |
| Rdh7 | uniprot | |
| Rdh5 | chemical | |
| Rdh12 | uniprot | |
| Dhrs3 | uniprot | |
| Rbp1 | uniprot | |
| Rbp2 | uniprot | |
| Rbp4 | uniprot | |
| Crabp1 | uniprot | |
| Crabp2 | uniprot | |
| ARAT | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh1a3 | uniprot | |
| Aldh8a1 | ||
| Dhrs3 | uniprot | |
| Rdh7 | uniprot | |
| Rlbp1 | uniprot | |
| Cyp26a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh1a3 | uniprot | |
| Aldh8a1 | ||
| all-trans ROL | ||
| 9-cis ROL | ||
| all-trans dehydro ROL | ||
| retinyl ester | hmdbid:HMDB03598 | |
| 11-cis ROL | ||
| 11-cis RAL | ||
| all-trans RAL | ||
| 9-cis RAL | ||
| all-trans dehydro RAL | ||
| all-trans RA | ||
| 9-cis RA | ||
| all-trans dehydro RA | ||
| ? | ||
| 5 | ||
| 5 | ||
| 5 | ||
| 5 | ||
| 1,2,3 | ||
| 1,2,3,4,6 | ||
| 7,8,9 | ||
| ROL=retinol; RAL=retinaldehyde; RA=retinoic acid | ||
| ROL-binding proteins | ||
| RAL-binding proteins | ||
| 11-cis binding protein | ||
| all-trans 4-oxo RA | ||
| all-trans 4-oxo dehydro RA | ||
| CYP26 Gene family | ||
| Nucleus | CHEBI:33252 | |
| RA-receptors |
| Cdk4 | uniprot | |
| Cdk6 | uniprot | |
| Ccnd1 | uniprot | |
| Ccnd2 | uniprot | |
| Ccnd3 | uniprot | |
| CyclinD | uniprot | |
| Cdk | uniprot | |
| Cdkn1a | uniprot | |
| Cdkn1b | uniprot | |
| Cdk7 | uniprot | |
| Ccnh | uniprot | |
| CyclinD | uniprot | |
| Cdk | uniprot | |
| Rb | ||
| E2f | uniprot | |
| E2f1 | uniprot | |
| E2f2 | uniprot | |
| E2f3 | uniprot | |
| Rbl1 | uniprot | |
| Rb1 | uniprot | |
| E2f4 | ||
| E2f5 | uniprot | |
| E2f6 | uniprot | |
| Rb | ||
| E2f | uniprot | |
| dp1 | uniprot | |
| Tfdp1 | uniprot | |
| Tfdp2 | uniprot | |
| Cdk2 | uniprot | |
| Ccne1 | uniprot | |
| Ccne2 | uniprot | |
| Pole2 | uniprot | |
| Pole | ||
| Cdc25a | uniprot | |
| Wee1 | uniprot | |
| Pkmyt1 | uniprot | |
| CyclinE | chemical | |
| Cdk | uniprot | |
| CyclinE | chemical | |
| Cdk | uniprot | |
| Cdc2a | uniprot | |
| Cdk4 | uniprot | |
| Cdk6 | uniprot | |
| Cdk7 | uniprot | |
| Cdc45l | uniprot | |
| Rpa2 | uniprot | |
| Rpa3 | uniprot | |
| Rpa1 | uniprot | |
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm5 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| Orc1l | uniprot | |
| Orc2l | uniprot | |
| Orc3l | uniprot | |
| Orc4l | uniprot | |
| Orc5l | uniprot | |
| Orc6l | uniprot | |
| Prim1 | uniprot | |
| Prim2 | uniprot | |
| Pola2 | uniprot | |
| Pcna | uniprot | |
| Trp53 | uniprot | |
| Gadd45a | uniprot | |
| Mdm2 | uniprot | |
| Cdkn2c | uniprot | |
| Cdkn2b | uniprot | |
| Cdkn2d | uniprot | |
| Cdkn2a | uniprot | |
| Cdc2a | uniprot | |
| Ccna1 | uniprot | |
| Ccnb1-rs1 | ||
| Atm | uniprot | |
| p53 | uniprot | |
| Cdkn1c | uniprot | |
| Ccng2 | uniprot | |
| Myc | uniprot | |
| Creb1 | uniprot | |
| Crebl1 | uniprot | |
| Creb3l1 | ||
| Creb3 | uniprot | |
| Creb3l4 | ||
| Creb3l3 | ||
| Mnat1 | uniprot | |
| G1 Cyclin | ||
| Cyclin Ds | chemical | |
| p | ||
| p | ||
| p | ||
| p | ||
| E2f | uniprot | |
| Rb | ||
| dp1 | uniprot | |
| Dependent Kinases | ||
| TTTCC/GCGC | ||
| Cell cycle DNA replication genes | ||
| G1 Phase | ||
| G1/S transition Phase | ||
| Dependent Kinases | ||
| Cyclin Es | chemical | |
| G1/S transition Cyclin | ||
| p | ||
| inactive | ||
| phosphorylation of proteins | ||
| involved in G1/S transition | ||
| DNA polymerases | uniprot | |
| DNA replication | ||
| origen recognition | ||
| complex | ||
| p | ||
| G1/S Cell Cycle | ||
| Checkpoint | ||
| G2 Phase-M phase | ||
| u | ||
| u | ||
| u | ||
| Degredation | ||
| p | ||
| e | ||
| cak | uniprot | |
| b | ||
| b | ||
| e |
| Hdac4 | chemical | |
| Orc4l | uniprot | |
| Mcm7 | uniprot | |
| Mcm6 | uniprot | |
| Mcm5 | uniprot | |
| Mcm4 | uniprot | |
| Mcm3 | uniprot | |
| Bub1b | uniprot | |
| Atm | uniprot | |
| Abl1 | uniprot | |
| Bub1 | uniprot | |
| Bub3 | uniprot | |
| Wee1 | uniprot | |
| Rb1 | uniprot | |
| Rb1 | uniprot | |
| Cdk2 | uniprot | |
| Cdk4 | uniprot | |
| Cdk6 | uniprot | |
| Ccnh | uniprot | |
| Gsk3b | uniprot | |
| Tgfb1 | uniprot | |
| Orc2l | uniprot | |
| Smad3 | uniprot | |
| Smad4 | uniprot | |
| Ccnd3 | uniprot | |
| Ccnd2 | uniprot | |
| Cdkn2a | uniprot | |
| Cdkn1b | uniprot | |
| Ccne1 | uniprot | |
| Ccna1 | uniprot | |
| Ccna2 | uniprot | |
| Pcna | uniprot | |
| Ywhag | uniprot | |
| Gadd45a | uniprot | |
| Cdc25a | uniprot | |
| Hdac1-ps | chemical | |
| Hdac2 | uniprot | |
| Hdac5 | uniprot | |
| Mcm2 | uniprot | |
| Cdk2 | uniprot | |
| Trp53 | uniprot | |
| Prkdc | uniprot | |
| Chek1 | uniprot | |
| Ccna2 | uniprot | |
| Ccna1 | uniprot | |
| Ccnb1 | uniprot | |
| Ccnb2 | uniprot | |
| Cdc2a | uniprot | |
| Rb1 | uniprot | |
| Tfdp1 | uniprot | |
| Rbl1 | uniprot | |
| Cdc45l | uniprot | |
| Cdkn1a | uniprot | |
| MEN | ||
| Mdm2 | uniprot | |
| E2f1 | uniprot | |
| E2f3 | uniprot | |
| E2f5 | uniprot | |
| Rbl1 | uniprot | |
| E2f6 | uniprot | |
| Cdc14A | ||
| Espl1 | uniprot | |
| Smc1l2 | uniprot | |
| Skp2 | uniprot | |
| Skp2 | uniprot | |
| Ep300 | ||
| ARF | uniprot | |
| Chek2 | uniprot | |
| Atr | uniprot | |
| Cdk2 | uniprot | |
| Cdc2a | uniprot | |
| Ccnb3 | uniprot | |
| Cdc6 | uniprot | |
| Ccne2 | uniprot | |
| AA545217 | ||
| Tbc1d8 | uniprot | |
| Cdc14B | ||
| Cdh1 | uniprot | |
| Cdc20 | uniprot | |
| Pttg1 | uniprot | |
| Mpeg1 | chemical | |
| Mad1l1 | uniprot | |
| Mad2l1 | uniprot | |
| Mad2l2 | uniprot | |
| Cdc25b | uniprot | |
| Cdc7 | uniprot | |
| Orc5l | uniprot | |
| Orc1l | uniprot | |
| Orc3l | uniprot | |
| Orc6l | uniprot | |
| Hdac3 | uniprot | |
| AL118125 | ||
| Hdac6 | uniprot | |
| Hdac7a | uniprot | |
| E2f2 | uniprot | |
| E2f4 | ||
| 14-3-3 | ||
| Plk1 | uniprot | |
| Cdc25c | uniprot | |
| Pkmyt1 | uniprot | |
| MAPK | enzyme | uniprot |
| signaling | ||
| pathway | ||
| Growth Factor | ||
| Growth Factor | ||
| withdrawal | ||
| R-point | ||
| (Start) | ||
| +p | ||
| e | ||
| e | ||
| p16,15,18,19 | ||
| p27,57 | ||
| p21 | uniprot | |
| Histone Deacetylases | uniprot | |
| +u | ||
| +u | ||
| +u | ||
| +p | ||
| e | ||
| e | ||
| e | ||
| Apoptosis | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| HDAC | ||
| E2F | ||
| DNA | CHEBI:16991 | |
| SCF | uniprot | |
| ORC | ||
| +p | ||
| DNA | CHEBI:16991 | |
| DNA biosynthesis | ||
| S-phase proteins | ||
| +p | ||
| SCF | uniprot | |
| APC/C | ||
| -p | ||
| +p | ||
| +u | ||
| APC/C | ||
| +u | ||
| DNA damage checkpoint | ||
| Separin | hmdbid:HMDB05005 | uniprot |
| Condensin | ||
| Transcription Factor E2F | ||
| Ubiquitin | uniprot | |
| mediated | ||
| proteolysis | chemical | |
| ORC (Origin | ||
| Recognition Complex) | ||
| MCM (Mini-Chromosome | ||
| Maintenance) complex | ||
| G1 | ||
| M | ||
| G2 | ||
| S | ||
| Securin | uniprot | |
| MCM | uniprot | |
| +p | ||
| +p | ||
| -p |
| Hmgcs1 | uniprot | |
| Hmgcr | uniprot | |
| Mvk | uniprot | |
| Pmvk | uniprot | |
| Mvd | uniprot | |
| Sqle | uniprot | |
| Dhcr7 | uniprot | |
| Idi1 | uniprot | |
| Fdps | uniprot | |
| Lss | uniprot | |
| Fdps | uniprot | |
| Fdft1 | uniprot | |
| Cyp51 | uniprot | |
| Sc4mol | uniprot | |
| Nsdhl | uniprot | |
| Sc5d | uniprot | |
| Fatty Acid Degradation | ||
| DiMethylally-PP | chemical | |
| Geranyl-PP | hmdbid:HMDB01285 | |
| trans-trans-farnesyl-pp | ||
| Delta-Isopentenyl-5-PP | chemical | |
| Mevalonate-5-P | chemical | |
| Mevalonate | hmdbid:HMDB00227 | |
| HMG-CoA | hmdbid:HMDB01375 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Lathosterol | hmdbid:HMDB01170 | |
| Lanosterol | hmdbid:HMDB01251 | |
| Squalene-2,3-Epoxide | hmdbid:HMDB01188 | |
| Squalene | hmdbid:HMDB00256 | |
| Mevalonate-5-PP | chemical | |
| 7-dehydro Cholesterol | hmdbid:HMDB00032 | |
| Cholesterol | hmdbid:HMDB00067 |
| Myf6 | uniprot |
| Bteb1 | uniprot |
| Herpud1 | uniprot |
| Sf3a3 | uniprot |
| Cbx3 | uniprot |
| Oazin | uniprot |
| Psma4 | uniprot |
| Zfr | |
| Sumo1 | uniprot |
| Hist1h2bn | uniprot |
| Pura | uniprot |
| Cry2 | uniprot |
| Per1 | uniprot |
| Per2 | uniprot |
| Cry1 | uniprot |
| Ppp1r3c | chemical |
| Cebpb | uniprot |
| Ppp2cb | uniprot |
| Ncoa4 | |
| Etv6 | uniprot |
| D14Ertd171e | uniprot |
| Hspa8 | uniprot |
| Dnaja1 | uniprot |
| Ucp3 | uniprot |
| Gstm3 | uniprot |
| Ugp2 | uniprot |
| Cldn5 | uniprot |
| Pigf | uniprot |
| Tubb4 | uniprot |
| Gfra1 | uniprot |
| Map3k7ip2 | uniprot |
| Sumo3 | uniprot |
| Gstp2 | uniprot |
| Nckap1 | uniprot |
| Vapa | uniprot |
| D5Ertd593e | uniprot |
| Dazap2 | uniprot |
| Idi1 | uniprot |
| Eif4g2 | uniprot |
| Tob1 | uniprot |
| Qk | |
| Rbpms | uniprot |
| G0s2 | uniprot |
| Arntl | uniprot |
| Nr1d2 | uniprot |
| Clock | |
| Btg1 | uniprot |
| H2-DMa | uniprot |
| Nr1d1 | uniprot |
| Per1 | uniprot |
| Per2 | uniprot |
| E-Box | |
| E-Box | |
| Cry1 | uniprot |
| Cry2 | uniprot |
| Per | |
| Cry | |
| Metabolism | |
| Chaperone | |
| Protein Modification | |
| Transcription | |
| Cell Cycle | |
| DNA/RNA Binding | |
| Other | |
| Structural/Cytoskeleton | |
| Signaling | |
| mHrts | |
| mHrts | |
| mHrts | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrp mSCNp | |
| mHrts | |
| mSCNp | |
| mHrts | |
| mLvrs | |
| mHrts | |
| mHrts | |
| mHrts | |
| mLvrs | |
| mLvrs | |
| mLvrp | |
| mLvrp | |
| mLvrp | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrs,p SCNp | |
| mHrts | |
| mLvrs | |
| mSCNp | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrp mSCNp | |
| mLvrs | |
| mLvrs | |
| mHrts | |
| mLvrp | |
| mSCNp | |
| mHrts | |
| mHrts | |
| mLvrs,p | chemical |
| mLvrp | |
| mLvrp | |
| mHrts Lvrsp | |
| mHrts mLvrs | |
| mLvrs,p | chemical |
| mHrts mLvrs, mSCNp | |
| Nucleus | CHEBI:33252 |
| mHrts mLvrs,p mSCN | |
| mHrts mLvrs,p | |
| mHrts mLvrs | |
| mHrts mLvrp | |
| mHrts mLvrs,p mSCNp | |
| E-Box | |
| E-Box | |
| Rev-erba | |
| E-Box | |
| e |
| C1qb | uniprot |
| C1qa | uniprot |
| C1qg | uniprot |
| C1r | uniprot |
| C1s | uniprot |
| Daf2 | uniprot |
| Daf1 | uniprot |
| C2 | |
| C4 | |
| C3 | |
| Hc | |
| C6 | |
| 1700013L23Rik | |
| C9 | |
| Masp1 | uniprot |
| C7 | |
| antigen/antibody | |
| complex | |
| C1 complex | |
| aggregated IgG, | |
| IgM-antigen complex, | |
| polyanions, RNA, DNA | |
| lipopolysacharides | |
| Membrane | |
| attack complex | |
| Ions | CHEBI:24870 |
| H O | |
| 2 | |
| Cytoplasm | |
| Plasma | |
| Membrane | |
| Prevents Complement Attack | |
| Proteolytic Cleavage | |
| Complex | |
| Formation |
| C1qb | uniprot | |
| C1qa | uniprot | |
| C1qg | uniprot | |
| C1r | uniprot | |
| C1s | uniprot | |
| Daf2 | uniprot | |
| Daf1 | uniprot | |
| C2 | ||
| C4 | ||
| C3 | ||
| Hc | ||
| C6 | ||
| 1700013L23Rik | ||
| C9 | ||
| Masp1 | uniprot | |
| Cd59a | uniprot | |
| Mcp | uniprot | |
| Crry | uniprot | |
| Cfi | uniprot | |
| Masp2 | uniprot | |
| Mbl1 | uniprot | |
| Serping1 | uniprot | |
| C4bp | uniprot | |
| C3ar1 | uniprot | |
| C5r1 | uniprot | |
| Cr2 | uniprot | |
| Cr1 | uniprot | |
| H2-Bf | uniprot | |
| Adn | uniprot | |
| Cfh | uniprot | |
| F3 | ||
| F7 | ||
| F9 | ||
| F8 | ||
| F11 | uniprot | |
| Vwf | uniprot | |
| F10 | uniprot | |
| F5 | ||
| F2 | ||
| Fgb | uniprot | |
| Serpind1 | uniprot | |
| Cpb2 | uniprot | |
| Tfpi | uniprot | |
| F13b | uniprot | |
| F2r | uniprot | |
| Serpinc1 | uniprot | |
| Serpina5 | uniprot | |
| Serpina1 | uniprot | |
| Proc | uniprot | |
| Pros1 | uniprot | |
| Plat | uniprot | |
| Plau | uniprot | |
| Thbd | uniprot | |
| Serpine1 | uniprot | |
| Plaur | uniprot | |
| Plg | uniprot | |
| F12 | uniprot | |
| Klkb1 | uniprot | |
| Kng1 | uniprot | |
| Serpinf2 | uniprot | |
| Bdkrb1 | uniprot | |
| C7 | ||
| A2m | uniprot | |
| membrane attack complex | ||
| Cell lysis | ||
| C3 | ||
| Convertase | ||
| C3b | ||
| Antibody/antigen | ||
| complex | ||
| C4b/2a | ||
| Muscle contraction, | ||
| Chemotaxis, | ||
| Phagocyte recruitment | ||
| Inflammation, etc. | ||
| C5a | ||
| C3a | ||
| C4a | uniprot | |
| C3b/4b, C3b, C3d | ||
| Mediators | ||
| Classical Pathway | ||
| C3b/Bb | ||
| insulin, etc. | ||
| Zymosan | ||
| Alternative Pathway | ||
| Complement Cascade | ||
| Lectin Pathway | ||
| Thrombin | enzyme | uniprot |
| Clot | ||
| fibrin degredation | ||
| Vascular injury | ||
| products | ||
| Fibrin | ||
| monomer | ||
| Cross-linked | ||
| fibrin polymer | ||
| Platelet, monocyte, | ||
| lymphocyte, | ||
| endothelial cells, | ||
| smooth muscle cells | ||
| activation, etc. | ||
| Coagulation Cascade | ||
| Extrinsic pathway | ||
| Degredation | ||
| Cell adhesion, | ||
| migration, | ||
| proliferation, etc. | ||
| Cell adhesion, | ||
| migration, | ||
| proliferation, etc. | ||
| Bradykinin | uniprot | |
| Collagen, | ||
| basement membrane, | ||
| activated platelets, etc. | ||
| Fibrinolytic system | ||
| Kinin kallikrein system |
| Tnf | uniprot |
| Il1b | uniprot |
| Il1a | uniprot |
| Il6 | uniprot |
| Tnf | uniprot |
| Il1b | uniprot |
| Il1a | uniprot |
| Tnf | uniprot |
| Tgfb1 | uniprot |
| Pdgfa | uniprot |
| Tnf | uniprot |
| Il1a | uniprot |
| Il1b | uniprot |
| Tnf | uniprot |
| Il1a | uniprot |
| Il1b | uniprot |
| Il6 | uniprot |
| Csf1 | uniprot |
| Csf2 | uniprot |
| Csf3 | uniprot |
| Cd4 | uniprot |
| Il1a | uniprot |
| Il1b | uniprot |
| Il6 | uniprot |
| Il10 | uniprot |
| Ifnb1 | uniprot |
| Tnf | uniprot |
| Il3 | uniprot |
| Il6 | uniprot |
| Csf2 | uniprot |
| Il3 | uniprot |
| Il4 | uniprot |
| Il10 | uniprot |
| Il13 | uniprot |
| Ifng | uniprot |
| Tnf | uniprot |
| Il2 | uniprot |
| Il15 | uniprot |
| Il2 | uniprot |
| Ifng | uniprot |
| Il15 | uniprot |
| Il3 | uniprot |
| Il4 | uniprot |
| Il10 | uniprot |
| Il4 | uniprot |
| Il10 | uniprot |
| Il4 | uniprot |
| Il6 | uniprot |
| Tgfb1 | uniprot |
| Il2 | uniprot |
| Il4 | uniprot |
| Il5 | uniprot |
| Il13 | uniprot |
| Ifng | uniprot |
| Il3 | uniprot |
| Il5 | uniprot |
| Tgfb1 | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Il11 | uniprot |
| Cxcl1 | uniprot |
| Cxcl1 | uniprot |
| Il12b | uniprot |
| Il12b | uniprot |
| Il12b | uniprot |
| Il15 | uniprot |
| Il7 | uniprot |
| Ifna | |
| Ifna | |
| Macrophage | |
| Neutrophil | |
| T-helper | |
| Hypothalamus | |
| Fibroblasts | |
| Endothelial Cells | |
| Inflammatory Response | |
| Hematopoietic Stem Cell | |
| Hematopoiesis | |
| TCR | |
| T-helper | |
| NK cell | |
| Lymphocyte Activated | |
| Mast Cell | |
| B Cell | |
| B Cell | |
| B Cell | |
| B Cell | |
| Plasma Cell | |
| Antibodies | |
| Killer Cells (LAK) | |
| Eos | |
| Eos | |
| Eos | |
| Th | |
| Th | |
| Th | |
| Tc | |
| Tc | |
| Tc | |
| clonal expansion of T cells | |
| (fever) | |
| MHC II |
| Notch1 | uniprot | |
| Notch2 | uniprot | |
| Notch3 | uniprot | |
| Notch4 | uniprot | |
| Dll1 | uniprot | |
| Dll4 | uniprot | |
| Jag1 | uniprot | |
| Jag2 | uniprot | |
| Psen1 | uniprot | |
| Psen2 | uniprot | |
| Aph1a | uniprot | |
| Aph1b | uniprot | |
| Psenen | uniprot | |
| Ncstn | uniprot | |
| Adam10 | uniprot | |
| Dll1 | uniprot | |
| Dll1 | uniprot | |
| Adam17 | uniprot | |
| Notch1 | uniprot | |
| Notch1 | uniprot | |
| Notch2 | uniprot | |
| Notch4 | uniprot | |
| Gsk3b | uniprot | |
| Notch2 | uniprot | |
| Gsk3b | uniprot | |
| Numb | ||
| Itch | uniprot | |
| App | ||
| Numbl | uniprot | |
| PIK3R1 | uniprot | |
| Pik3r2 | uniprot | |
| Akt1 | uniprot | |
| Furin | enzyme | uniprot |
| Cntn1 | uniprot | |
| Nov | ||
| Dtx1 | uniprot | |
| Ascl1 | uniprot | |
| Ep300 | ||
| Trp53 | uniprot | |
| Lfng | uniprot | |
| Mfng | uniprot | |
| Pofut1 | uniprot | |
| Skp1a | uniprot | |
| Fbxw7 | uniprot | |
| Hey1 | uniprot | |
| Maml2 | ||
| MAML3 | uniprot | |
| Maml1 | uniprot | |
| SNW1 | uniprot | |
| Ncor2 | uniprot | |
| Ncor1 | uniprot | |
| Hdac1 | uniprot | |
| 1700023B02Rik | ||
| Sap30 | uniprot | |
| Hdac2 | uniprot | |
| Sin3a | uniprot | |
| Hes1 | uniprot | |
| Stat3 | uniprot | |
| Jak2 | uniprot | |
| Ncor1 | uniprot | |
| Ncor2 | uniprot | |
| Rela | uniprot | |
| Nfkbia | uniprot | |
| Hey2 | uniprot | |
| Tle1 | uniprot | |
| Rela | uniprot | |
| Smad3 | uniprot | |
| Smad4 | uniprot | |
| Yy1 | uniprot | |
| CDK2 | uniprot | |
| Lef1 | uniprot | |
| Mef2c | uniprot | |
| Skp1a | uniprot | |
| Cul1 | uniprot | |
| Skp2 | uniprot | |
| Rbx1 | uniprot | |
| Tcfe2a | uniprot | |
| Mapk3 | uniprot | |
| Mapk1 | uniprot | |
| Wdr12 | uniprot | |
| Pcaf | chemical | |
| Fhl1 | uniprot | |
| Ring1 | uniprot | |
| Hivep3 | ||
| SPEN | uniprot | |
| Ep300 | ||
| Smad1 | uniprot | |
| Hes6 | uniprot | |
| Zfpm1 | uniprot | |
| MAGEA1 | uniprot | |
| Cntfr | uniprot | |
| Cntf | uniprot | |
| Hes5 | uniprot | |
| Lck | uniprot | |
| Stat3 | uniprot | |
| Jun | uniprot | |
| Rbpsuh | uniprot | |
| Notch3 | uniprot | |
| Dtx1 | uniprot | |
| Skp2 | uniprot | |
| Egf | uniprot | |
| Egfr | uniprot | |
| Jag1 | uniprot | |
| Jag1 | uniprot | |
| Jag2 | uniprot | |
| Notch1 | uniprot | |
| Dll4 | uniprot | |
| Jag2 | uniprot | |
| Notch3 | uniprot | |
| Notch1 | uniprot | |
| Notch1 | uniprot | |
| Notch2 | uniprot | |
| Molecular association | ||
| Phosphorylation | chemical | |
| Proteolytic Cleavage | ||
| Ubiquitination | ||
| Translocation | ||
| Gamma secretase complex | ||
| Intracellular Domain | ||
| -- ICD | ||
| ICD | ||
| ICD | ||
| ICD | ||
| ICD | ||
| ICD | ||
| Glycosylation | ||
| PM | ||
| GO->PM | ||
| CY->NU | ||
| NU->CY | ||
| PM->NU | ||
| PM->NU | ||
| PM->NU | ||
| NU->CY | ||
| NU->CY | ||
| D | ||
| D | ||
| D | ||
| GO->PM | ||
| PM->CY | ||
| PM->NU | ||
| ICD | ||
| (Protein-protein interaction) | ||
| Activation | chemical | |
| Inhibition | chemical | |
| D | ||
| Reactioin through unknown mechanisms/molecules | ||
| Receptor | ||
| Ligand | ||
| Gene Symbol | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| CY | ||
| Plasma membrane | ||
| Cytoplasm | ||
| GO | ||
| Golgi apparatus | ||
| Nucleus | CHEBI:33252 | |
| NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| Accession Number: NetPath_3; cellmap:3 | ||
| Enzyme complex | ||
| D | ||
| D | ||
| CY->NU | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Sumoylation | chemical | |
| Desumoylation | ||
| Deubiquitination | ||
| Recruitment | ||
| Control | ||
| EC | ||
| Extracellular | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| MT | ||
| Mitochondrion |
| Mcm10 | uniprot | |
| Ubb | uniprot | |
| Orc2l | uniprot | |
| Orc1l | uniprot | |
| Orc6l | uniprot | |
| Cdc6 | uniprot | |
| Gmnn | uniprot | |
| Ris2 | uniprot | |
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm5 | uniprot | |
| Mcm6 | uniprot | |
| Cdk2 | uniprot | |
| AA545217 | ||
| Cdc7 | uniprot | |
| Rpa2 | uniprot | |
| Rpa1 | uniprot | |
| Rpa3 | uniprot | |
| Prim1 | uniprot | |
| Prim2 | uniprot | |
| Pole2 | uniprot | |
| Pole | ||
| Pola2 | uniprot | |
| Pola1 | uniprot | |
| Pcna | uniprot | |
| Rfc5 | uniprot | |
| Rfc4 | uniprot | |
| Rfc3 | uniprot | |
| Rfc2 | uniprot | |
| Recc1 | uniprot | |
| Pold2 | uniprot | |
| Pold3 | uniprot | |
| Pold4 | uniprot | |
| Pold1 | uniprot | |
| Orc3l | uniprot | |
| Orc5l | uniprot | |
| Orc4l | uniprot | |
| Mcm7 | uniprot | |
| Cdc45l | uniprot | |
| Wbscr5 | uniprot | |
| Origin | ||
| Orc3 | uniprot | |
| Orc2 | uniprot | |
| Orc5 | uniprot | |
| Orc2 | uniprot | |
| Orc3 | uniprot | |
| Orc5 | uniprot | |
| Orc4 | uniprot | |
| Orc1 | uniprot | |
| Orc3 | uniprot | |
| Orc5 | uniprot | |
| Orc4 | uniprot | |
| Orc2 | uniprot | |
| Orc Complex | ||
| Phosphorylation of Mcm 2-7 complex | ||
| primase | ||
| DNA polymerase alpha: primase: origin complex | ||
| DNA polymerase alpha: primase: origin complex | ||
| CTP | hmdbid:HMDB00082 | uniprot |
| GTP | hmdbid:HMDB01273 | |
| UTP | hmdbid:HMDB00285 | |
| ATP | hmdbid:HMDB00538 | |
| RNA Primer | ||
| dCTP | hmdbid:HMDB00998 | |
| dGTP | hmdbid:HMDB01440 | |
| dUTP | hmdbid:HMDB01191 | |
| dATP | hmdbid:HMDB01532 | |
| Prereplicative complex | ||
| Phosphorylated Orc1 | ||
| Ubiquitin | uniprot | |
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| Phosphorylated Cdc6 | ||
| Ubiquitinated Orc1 | ||
| Ubiquitinated Cdc6 | ||
| Degraded by proteasome in cytosol | ||
| Degraded by proteasome in cytosol | ||
| RNA primer-DNA primer | ||
| RNA primer-DNA primer | ||
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| p49 | uniprot | |
| p58 | uniprot | |
| p70 | uniprot | |
| p180 | uniprot | |
| RFC36 | uniprot | |
| RFC37 | uniprot | |
| RFC38 | uniprot | |
| RFC40 | uniprot | |
| RFC140 | uniprot | |
| Mcm 4,6,7 trimer forms and associates | ||
| Ubiquitin | uniprot | |
| with the replication fork | ||
| Orc2 | uniprot | |
| Orc3 | uniprot | |
| a | ||
| RFC Heteropentamer:RNA primer-DNA primer | ||
| ATP | hmdbid:HMDB00538 | |
| PCNA homotrimer | ||
| RFC Heteropentamer:RNA primer-DNA primer: | ||
| RNA primer-DNA primer:origin duplex:PCNA | ||
| 2. Activation of the pre-replicative complex | ||
| 3. DNA replication initiation | ||
| 4. Switching of origins to post-replicative state | ||
| 1. Assembly of the pre-replicative complex | ||
| 5. Leading/lagging strand synthesis | ||
| Orc complex | ||
| Orc complex | ||
| Orc complex | ||
| Orc complex | ||
| Pre-replicative complex | ||
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm5 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm5 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| Mcm10 | uniprot | |
| Cdc6 | uniprot | |
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Cdt1 | uniprot | |
| Geminin | uniprot | |
| DNA polymerase | uniprot | |
| Processive complex |
| Egf | uniprot |
| Raf1 | uniprot |
| Hras1 | uniprot |
| Nras | uniprot |
| Kras | uniprot |
| Shoc2 | uniprot |
| PIK3R1 | uniprot |
| Map3k2 | uniprot |
| Grb14 | uniprot |
| Grb2 | uniprot |
| Grb10 | uniprot |
| Map3k3 | uniprot |
| Sos1 | uniprot |
| Grb7 | uniprot |
| Pik3r2 | uniprot |
| Shc1 | uniprot |
| Pik3r3 | uniprot |
| Pik3ca | uniprot |
| Pik3cb | uniprot |
| Pik3cd | uniprot |
| Pik3cg | uniprot |
| Gab1 | uniprot |
| Gab2 | uniprot |
| Jak1 | uniprot |
| Stat1 | uniprot |
| Jak2 | uniprot |
| Stat3 | uniprot |
| Stat5a | uniprot |
| Stat2 | uniprot |
| Stat5b | uniprot |
| Map2k1 | uniprot |
| Prkca | uniprot |
| MAP3K1 | uniprot |
| Prkcz | uniprot |
| Prkcm | uniprot |
| Prkci | uniprot |
| Prkcb1 | uniprot |
| PRKCG | uniprot |
| Map2k2 | uniprot |
| Map2k3 | uniprot |
| Map2k5 | uniprot |
| Map3k4 | uniprot |
| Vav1 | uniprot |
| Vav3 | uniprot |
| Vav2 | uniprot |
| Mapk7 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Elk4 | uniprot |
| Elk1 | uniprot |
| Mapk8 | uniprot |
| Map2k7 | |
| Ptprr | uniprot |
| Gja1 | uniprot |
| Ywhab | uniprot |
| Wnk1 | uniprot |
| Egfr | uniprot |
| Krt2-7 | |
| Krt2-8 | uniprot |
| Krt1-17 | uniprot |
| Krt1-18 | uniprot |
| LOC382523 | |
| Snrpd2 | uniprot |
| EPPK1 | uniprot |
| Plec1 | uniprot |
| Ptpn12 | uniprot |
| Stat3 | uniprot |
| Stat1 | uniprot |
| Src | uniprot |
| Cbl | uniprot |
| Crk | uniprot |
| Crkl | uniprot |
| Ndufa13 | uniprot |
| Rac1 | uniprot |
| Ptk2b | uniprot |
| Cav1 | uniprot |
| Cav2 | uniprot |
| Nck1 | |
| Nck2 | uniprot |
| Plcg1 | uniprot |
| Git1 | uniprot |
| Rgs16 | uniprot |
| Socs1 | uniprot |
| Socs3 | uniprot |
| Inppl1 | |
| Rab5a | uniprot |
| Usp6nl | uniprot |
| Arf4 | uniprot |
| Zfp259 | uniprot |
| Ripk1 | uniprot |
| Map3k14 | uniprot |
| Ralgds | uniprot |
| Rasa1 | uniprot |
| Ptk6 | uniprot |
| Prkar1a | uniprot |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Plscr1 | uniprot |
| Errfi1 | uniprot |
| Dok2 | uniprot |
| Pitpna | uniprot |
| Cblc | uniprot |
| Cblb | uniprot |
| Pld2 | uniprot |
| Pld1 | uniprot |
| Prkca | uniprot |
| Eps15 | uniprot |
| Eps8 | uniprot |
| Hdh | uniprot |
| Pik3c2b | |
| Sh3bgrl | uniprot |
| Csk | uniprot |
| Reps2 | uniprot |
| Ralbp1 | uniprot |
| Ralb | uniprot |
| Reps1 | uniprot |
| Tnk2 | uniprot |
| ABI1 | uniprot |
| Sos2 | uniprot |
| Dnm1 | uniprot |
| Sh3gl3 | uniprot |
| Cdc42 | uniprot |
| Spry2 | uniprot |
| Jund1 | uniprot |
| Fos | uniprot |
| Cebpa | uniprot |
| Myc | uniprot |
| Cebpb | uniprot |
| Pebp1 | uniprot |
| Tieg3 | uniprot |
| Sin3a | uniprot |
| Tgif | uniprot |
| Hdac1 | uniprot |
| Sh3kbp1 | uniprot |
| Sh3gl2 | uniprot |
| Jun | uniprot |
| Sp1 | uniprot |
| Akt1 | uniprot |
| Ptpn5 | uniprot |
| Snca | uniprot |
| Rps6ka1 | uniprot |
| Rps6ka3 | uniprot |
| Rps6ka2 | uniprot |
| Ap2a1 | uniprot |
| Wasl | uniprot |
| Ceacam1 | uniprot |
| Eef1a1 | uniprot |
| 2900057D21Rik | |
| Dip3b | uniprot |
| Mta2 | uniprot |
| Eps15l1 | uniprot |
| Epn1 | uniprot |
| Hip1 | uniprot |
| Rfxank | uniprot |
| Mapk14 | uniprot |
| Tnip1 | uniprot |
| Egfr | uniprot |
| Egfr | uniprot |
| Rbbp7 | uniprot |
| Ddef1 | uniprot |
| Stxbp1 | uniprot |
| Ctnnd1 | uniprot |
| Pkn2 | uniprot |
| Pak1 | uniprot |
| Sh2d3c | uniprot |
| Bcar1 | uniprot |
| Casp9 | |
| Rps6ka5 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| ATF1 | uniprot |
| Creb1 | uniprot |
| Foxo1 | uniprot |
| Pxn | uniprot |
| Elf3 | |
| Hat1 | uniprot |
| Camk2a | uniprot |
| Itch | uniprot |
| Araf | uniprot |
| Mcf2 | chemical |
| Elf3 | |
| Rps6ka3 | uniprot |
| Map3k2 | uniprot |
| Foxo1 | uniprot |
| Eps15 | uniprot |
| Eef1a1 | uniprot |
| Stat1 | uniprot |
| Stat3 | uniprot |
| Stat2 | uniprot |
| Stat5a | uniprot |
| Zfp259 | uniprot |
| Plcg1 | uniprot |
| Spry2 | uniprot |
| Plcg2 | uniprot |
| Plcg2 | uniprot |
| Ptpn6 | uniprot |
| Raf1 | uniprot |
| Gab1 | uniprot |
| Shc1 | uniprot |
| Pld1 | uniprot |
| Bcar1 | uniprot |
| Sh2d3c | uniprot |
| Stxbp1 | uniprot |
| 2900057D21Rik | |
| 2900057D21Rik | |
| Dip3b | uniprot |
| Mapk1 | uniprot |
| Map2k1 | uniprot |
| Dusp1 | uniprot |
| Dusp1 | uniprot |
| Arf4 | uniprot |
| Arf4 | uniprot |
| Egf | uniprot |
| Egf | uniprot |
| Sh3gl2 | uniprot |
| Egfr | uniprot |
| Molecular association | |
| Translocation | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Enzyme complex | |
| Plasma membrane | |
| Extracellular | |
| Gene Symbol | |
| PM | |
| CY | |
| PM | |
| NU | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| CY | |
| NU | |
| NU | |
| CY | |
| MA | |
| MA | |
| MA | |
| MA | |
| CY | |
| NU | |
| NU | |
| CY | |
| CY | |
| NU | |
| NU | |
| CY | |
| CY | |
| PM | |
| NU | |
| CY | |
| MA | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| CY | |
| NU | |
| PM | |
| CY | |
| PM | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| NU | |
| PM | |
| CY | |
| PM | |
| EN | |
| PM | |
| EN | |
| PM | |
| CY | |
| NU | |
| EC | |
| Proteins in a complex interaction | |
| (Protein-protein interaction) | |
| Autodephosphorylation | chemical |
| Acetylation | chemical |
| Accession Number : NetPath_4; cellmap:4 | |
| MA | |
| MA | |
| D | |
| D | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| MA | |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT |
| Pla2g6 | uniprot | |
| Alox5ap | uniprot | |
| Alox5 | uniprot | |
| Tbxas1 | uniprot | |
| Ptgs1 | uniprot | |
| Ptgs2 | uniprot | |
| Ptgis | uniprot | |
| Ptgds | uniprot | |
| Ptges | uniprot | |
| PGD2 11-ketoreduc | ||
| Lta4h | uniprot | |
| Alox5ap | uniprot | |
| Alox5 | uniprot | |
| Peroxidase? | ||
| Peroxidase? | ||
| Ltc4s | uniprot | |
| Dpep1 | uniprot | |
| Alox15 | uniprot | |
| Alox12e | uniprot | |
| Alox12 | uniprot | |
| Alox15b | uniprot | |
| Pla2g5 | uniprot | |
| Pla2g2c | uniprot | |
| Pla2g2a | uniprot | |
| Pla2g12a | uniprot | |
| Ggt1 | uniprot | |
| Ptges2 | uniprot | |
| Peroxidase? | ||
| PGE2 9-ketoreduc | ||
| Cell Membrane | ||
| Arachadonic Acid | chemical | |
| PGH2 | hmdbid:HMDB01381 | |
| 5-HPETE | ||
| 12-HPETE | ||
| 15-HPETE | ||
| 15-HETE | ||
| 12-HETE | CHEBI:19138 | |
| LTC4 | hmdbid:HMDB01198 | |
| LTD4 | CHEBI:28666 | |
| LTE4 | hmdbid:HMDB02200 | |
| PGI2 | hmdbid:HMDB01335 | uniprot |
| PGF2-alpha | chemical | |
| PGE2 | hmdbid:HMDB01220 | |
| PGD2 | hmdbid:HMDB01403 | |
| TXA2 | hmdbid:HMDB01452 | |
| Lipox = Lipoxygenase | ||
| ETE = Eicosatetraenoic Acid | ||
| HP = Hydroperoxy | ||
| H = Hydroxy | ||
| diH = Dihydroxy | ||
| PG = Prostaglandin | ||
| LT = Leukotriene | ||
| TX = Thromboxane | ||
| 6-KetoPGF2-alpha | chemical | |
| 5-HETE | CHEBI:28209 | |
| LTA4 | hmdbid:HMDB01337 | uniprot |
| LTB4 | uniprot | |
| TXA3 | ||
| TXB2 | CHEBI:28728 |
| Atpif1 | uniprot |
| Cox6c | uniprot |
| Cox17 | uniprot |
| Surf1 | uniprot |
| Ucp1 | uniprot |
| Ucp2 | uniprot |
| Ucp3 | uniprot |
| Cycs | uniprot |
| Cyct | uniprot |
| COX1 | uniprot |
| COX2 | uniprot |
| COX3 | uniprot |
| Cox4i1 | uniprot |
| Cox5a | uniprot |
| Cox5b | uniprot |
| Cox6a2 | uniprot |
| Cox6a1 | uniprot |
| Cox6b1 | uniprot |
| Cox7a1 | uniprot |
| Cox7a2 | uniprot |
| Cox7b | uniprot |
| Cox7c | uniprot |
| Cox8b | uniprot |
| Cox8a | uniprot |
| ATP8 | uniprot |
| Slc25a4 | uniprot |
| Slc25a5 | uniprot |
| Atp5a1 | uniprot |
| Atp5b | uniprot |
| Atp5c1 | uniprot |
| Atp5d | uniprot |
| Atp5e | uniprot |
| Atp5j | uniprot |
| Atp5o | uniprot |
| ATP6 | uniprot |
| Atp5f1 | uniprot |
| Atp5g1 | uniprot |
| Atp5g2 | uniprot |
| Atp5g3 | uniprot |
| Atp5h | uniprot |
| Atp5k | uniprot |
| Atp5j2 | uniprot |
| Atp5l | uniprot |
| Slc25a14 | uniprot |
| Cox7a2l | uniprot |
| ND2 | uniprot |
| ND3 | uniprot |
| ND4 | uniprot |
| ND5 | uniprot |
| ND6 | uniprot |
| ND4L | uniprot |
| Ndufa1 | uniprot |
| Ndufa4 | uniprot |
| Ndufs6 | uniprot |
| Ndufa3 | uniprot |
| Sdha | uniprot |
| Sdhb | uniprot |
| Sdhc | uniprot |
| Sdhd | uniprot |
| Uqcrc1 | uniprot |
| Uqcrc2 | uniprot |
| Uqcrh | uniprot |
| CYTB | uniprot |
| 1500040F11Rik | |
| ND1 | uniprot |
| Ndufa2 | uniprot |
| Ndufa6 | uniprot |
| Ndufb4 | uniprot |
| Ndufb9 | uniprot |
| Ndufb2 | uniprot |
| Ndufb10 | uniprot |
| AI256775 | |
| Atp5s | uniprot |
| Slc25a27 | |
| Ndufa7 | uniprot |
| Ndufab1 | uniprot |
| Ndufa5 | uniprot |
| Ndufa8 | uniprot |
| Ndufv2 | uniprot |
| Ndufs3 | uniprot |
| Ndufa9 | uniprot |
| Ndufa10 | uniprot |
| Uqcrb | uniprot |
| C subunit | |
| F1 Complex | |
| Stalk | |
| F0 Complex | |
| binds ATP Synthase beta | |
| Uncoupling Protein | |
| Complex I | uniprot |
| Complex IV | |
| Complex III | |
| Complex II | |
| Oxidoreductase | enzyme |
| NADH-Ubiquinone | chemical |
| Succinate-Ubiquinone | chemical |
| Oxidoreductase | enzyme |
| Ubiquinol-Cytochrome C | chemical |
| Reductase | enzyme |
| Cytochrome C | |
| Oxidase | |
| ATP Synthase (Complex V) | |
| Adenine Nucleotide | chemical |
| Translocator | |
| Ubiquinone | hmdbid:HMDB02012 |
| Assembly |
| Lifr | uniprot | |
| Il6st | uniprot | |
| Jak1 | uniprot | |
| Jak1 | uniprot | |
| Stat3 | uniprot | |
| Ptpn11 | uniprot | |
| Stat3 | uniprot | |
| Lrp5 | uniprot | |
| Dvl1 | uniprot | |
| Dvl2 | uniprot | |
| Dvl3 | uniprot | |
| Axin1 | uniprot | |
| Gsk3b | uniprot | |
| Apc | uniprot | |
| Ctnnb1 | uniprot | |
| Ctnnb1 | uniprot | |
| Tcf1 | uniprot | |
| Ctnnb1 | uniprot | |
| Bmp4 | uniprot | |
| Lif | uniprot | |
| Wnt2 | uniprot | |
| Wnt1 | uniprot | |
| Wnt2b | uniprot | |
| Wnt3 | uniprot | |
| Wnt3a | uniprot | |
| Wnt4 | uniprot | |
| Wnt5a | uniprot | |
| Wnt5b | uniprot | |
| Wnt6 | uniprot | |
| Wnt7a | uniprot | |
| Wnt7b | uniprot | |
| Wnt10a | uniprot | |
| Wnt10b | uniprot | |
| Wnt11 | uniprot | |
| Wnt9b | uniprot | |
| Wnt16 | uniprot | |
| Grb2 | uniprot | |
| Sos1 | uniprot | |
| Gab1 | uniprot | |
| Eras | uniprot | |
| Raf1 | uniprot | |
| Braf | uniprot | |
| Araf | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Map2k3 | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Sepp1 | uniprot | |
| Mapk1 | uniprot | |
| Mapk4 | uniprot | |
| Mapk6 | uniprot | |
| Mapk7 | uniprot | |
| Mapk12 | uniprot | |
| Pik3r2 | uniprot | |
| Pik3cd | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Akt3 | uniprot | |
| Pten | uniprot | |
| Egf | uniprot | |
| Pdgfrb | uniprot | |
| Pdgfra | uniprot | |
| Fgfr1 | uniprot | |
| Fgf14 | uniprot | |
| Fgf1 | uniprot | |
| Fgf2 | uniprot | |
| Fgfr4 | uniprot | |
| Fgf10 | uniprot | |
| Fgf3 | uniprot | |
| Fgf5 | uniprot | |
| Fgf6 | uniprot | |
| Fgf7 | uniprot | |
| Fgf8 | uniprot | |
| Fgf9 | uniprot | |
| Fgfr3 | uniprot | |
| Fgfr2 | uniprot | |
| Fgf18 | uniprot | |
| Fgf12 | uniprot | |
| Fgf15 | uniprot | |
| Fgf13 | uniprot | |
| Fgf17 | uniprot | |
| Fgf23 | uniprot | |
| Fgf20 | uniprot | |
| Fgf22 | uniprot | |
| Fgf16 | uniprot | |
| Fgf21 | uniprot | |
| Fgf4 | uniprot | |
| Fgf11 | uniprot | |
| Egfr | uniprot | |
| Pdgfb | uniprot | |
| Pdgfa | uniprot | |
| Lrp6 | uniprot | |
| Fzd1 | uniprot | |
| Fzd2 | uniprot | |
| Fzd3 | uniprot | |
| Fzd4 | uniprot | |
| Fzd5 | uniprot | |
| Fzd6 | uniprot | |
| Fzd7 | uniprot | |
| Fzd8 | uniprot | |
| Fzd9 | uniprot | |
| Stat3 | uniprot | |
| Stat3 | uniprot | |
| Acvr1 | uniprot | |
| Bmpr1a | uniprot | |
| Bmpr1b | uniprot | |
| Bmpr2 | uniprot | |
| actr2 | uniprot | |
| Smad1 | uniprot | |
| Smad5 | uniprot | |
| Smad4 | uniprot | |
| Smad6 | uniprot | |
| Smad7 | uniprot | |
| Smad9 | uniprot | |
| Smad1 | uniprot | |
| Smad5 | uniprot | |
| Smad9 | uniprot | |
| Smad1 | uniprot | |
| Smad5 | uniprot | |
| Smad9 | uniprot | |
| Smad4 | uniprot | |
| actr2b | ||
| Myc | uniprot | |
| +p | ||
| +p | ||
| +p | ||
| Degradation of beta-catenin | ||
| Nucleus | CHEBI:33252 | |
| +p | ||
| R-Smad / Co-Smad | ||
| RAF | ||
| MEK | hmdbid:HMDB00474 | |
| ERK | enzyme | uniprot |
| Ras-GTP | chemical | |
| Ras-GDP | chemical | |
| Elk | uniprot | |
| c-Fos | ||
| c-Jun | ||
| PIP3 | uniprot | |
| +p | ||
| PI3 kinase | enzyme | uniprot |
| mdm2 | uniprot | |
| mTOR | uniprot | |
| IKK | enzyme | |
| Ca++ | ||
| PKC | enzyme | uniprot |
| JNK | enzyme | uniprot |
| PDE | ||
| non-canonical pathway | ||
| Ras/ERK pathway | ||
| LIF Signaling | ||
| PI3 Kinase / Akt signaling | ||
| Self-renewal | ||
| Self-renewal | ||
| Self-renewal | ||
| Wnt signaling | ||
| BMP signaling | ||
| Frizzled ligands | ||
| +p | ||
| +p | ||
| +p | ||
| Inhibits self-renewal (promotes differentiation) | ||
| Nucleus | CHEBI:33252 | |
| Self-renewal | ||
| -p | ||
| -p Dephosphorylation | ||
| b | ||
| b | ||
| Gi Signaling | ||
| R-Smad / Co-Smad complex | ||
| b | ||
| PIP2 | uniprot | |
| PIP2 | uniprot | |
| GPCR-Arrestin Signals | ||
| G12 Signaling | ||
| Promotes self-renewal (inhibits differentiation) | ||
| +p Pshophorylation | ||
| b Binding |
| Daxx | uniprot |
| Daxx | uniprot |
| Fasl | uniprot |
| Fas | uniprot |
| Hspb1 | uniprot |
| Tnf | uniprot |
| Il1a | uniprot |
| Mapkapk2 | uniprot |
| Mapkapk3 | uniprot |
| Cycs | uniprot |
| Bcl2 | uniprot |
| Casp9 | |
| Apaf1 | uniprot |
| Apaf1 | uniprot |
| Casp3 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| actin | uniprot |
| Fadd | uniprot |
| Faf1 | uniprot |
| Faf1 | uniprot |
| Ptpn13 | uniprot |
| Casp8 | uniprot |
| Casp8 | uniprot |
| Cflar | uniprot |
| Ripk2 | uniprot |
| casp10 | |
| Casp7 | uniprot |
| Casp3 | uniprot |
| Parp1 | uniprot |
| Pak1 | uniprot |
| Pak2 | uniprot |
| Arhgdib | uniprot |
| Spna1 | uniprot |
| Dffa | uniprot |
| Dffb | uniprot |
| Dffb | uniprot |
| Prkdc | uniprot |
| Casp6 | uniprot |
| Lmna | uniprot |
| Lmnb1 | uniprot |
| Lmnb2 | uniprot |
| Rb1 | uniprot |
| Map3k1 | uniprot |
| Map2k4 | uniprot |
| Mapk8 | uniprot |
| Map3k7 | uniprot |
| Jun | uniprot |
| Stress | |
| Mitochondria Pathway | |
| Apoptosome | |
| Proteasome | enzyme |
| NFK-B | |
| Pathway | |
| ROS | CHEBI:26523 |
| Cell Survival | |
| Necrosis | |
| P | |
| Apoptosis | |
| FAS Pathway | |
| P | |
| P | |
| 3x-P | |
| 3x-P | |
| 3x-P | |
| DNA presentation | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| Ceramide | hmdbid:HMDB04957 |
| Extracellular | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Stress Induction of HSP regulation | |
| Cut | |
| Inhibition | chemical |
| Activate | |
| Self-activation | |
| Glutathione | hmdbid:HMDB00125 |
| Lpl | uniprot | |
| Tpi1 | uniprot | |
| Gyk | uniprot | |
| Gk2 | ||
| Gpd2 | uniprot | |
| Cpt2 | uniprot | |
| Cpt1a | uniprot | |
| Chkb | uniprot | |
| Slc25a20 | uniprot | |
| Crat | uniprot | |
| Acsl1 | uniprot | |
| Acas2 | uniprot | |
| Acsl3 | uniprot | |
| Acsl4 | uniprot | |
| Acsl5 | uniprot | |
| Acsl6 | uniprot | |
| Cpt1b | uniprot | |
| Acadvl | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Hadhb | uniprot | |
| Hadha | uniprot | |
| Acadl | uniprot | |
| Hadhb | uniprot | |
| Hadha | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Acadl | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Lipe | uniprot | |
| Lipc | uniprot | |
| Pnpla2 | chemical | |
| Lipf | uniprot | |
| Triacylglycerol | chemical | |
| Glycerol | hmdbid:HMDB00131 | |
| Dihydroxyacetone Phosphate | hmdbid:HMDB01473 | |
| Fatty Acid | CHEBI:35366 | |
| Acyl-CoA | CHEBI:17984 | |
| Palmitoyl-CoA | hmdbid:HMDB01338 | |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 | |
| L-Glycerol-3-Phosphate | chemical | |
| See Glycolysis MAPP | ||
| Trans-Hexadecanoyl-CoA | chemical | |
| (S)-3-Hydroxyhexadecanoyl-CoA | chemical | |
| 3-Oxopalmitoyl-CoA | hmdbid:HMDB06402 | |
| Myristoyl-CoA | CHEBI:15532 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Trans-Tetradex-2-enoyl-CoA | chemical | |
| (S)-3-Hydroxytetradecanoyl-CoA | chemical | |
| Dxotetradecanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Lauroyl-CoA | hmdbid:HMDB03571 | |
| 2-trans-dodecenoyl-CoA | CHEBI:15471 | |
| (S)-3-Hydroxydodexanonyl-CoA | chemical | |
| 3-Oxododexanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Decanoyl-CoA | CHEBI:28493 | |
| See Beta Oxidation 2 MAPP | ||
| Lipases | enzyme | uniprot |
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP |
| Acadm | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Acadm | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Acads | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Decanoyl-CoA | CHEBI:28493 | |
| See Beta Oxidation 1 MAPP | ||
| Trans-Dec-2-enoyl-CoA | CHEBI:10723 | |
| (S)-3-Hydroxydecanoyl-CoA | chemical | |
| 3-Oxocanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Octaoyl-CoA | chemical | |
| Trans-Oct-2-enoyl-CoA | CHEBI:27537 | |
| (S)-3-Hydroxyoctanoyl-CoA | chemical | |
| 3-Oxo-octanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Hexanoyl-CoA | hmdbid:HMDB02845 | |
| See Beta Oxidation Unsaturated MAPP | ||
| Trans-Hex-2-enoyl-CoA | CHEBI:28706 | |
| (S)-Hydrocyhexanoyl | chemical | |
| 3-Oxohexanoyl-CoA | CHEBI:27648 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Butanoyl-CoA | hmdbid:HMDB01088 | |
| See Beta Oxidation 3 MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP |
| Acads | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Gcdh | uniprot | |
| Dld | uniprot | |
| Acat1 | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Butanoyl-CoA | hmdbid:HMDB01088 | |
| See Beta Oxidation 2 | ||
| Cronoyl-CoA | chemical | |
| (S)-3-Hydroxybutanoyl-CoA | hmdbid:HMDB01166 | |
| Acetoacetyl-CoA | hmdbid:HMDB01484 | |
| Glutaryl-CoA | hmdbid:HMDB01339 | |
| Glutarate | hmdbid:HMDB00661 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| See TCA Cycle |
| Lpl | uniprot |
| Gyk | uniprot |
| Gk2 | |
| Gpd2 | uniprot |
| Tpi1 | uniprot |
| Acsl1 | uniprot |
| Acsl3 | uniprot |
| Acsl4 | uniprot |
| Acsl5 | uniprot |
| Acsl6 | uniprot |
| Crat | uniprot |
| Cpt1a | uniprot |
| Chkb | uniprot |
| Cpt2 | uniprot |
| Slc25a20 | uniprot |
| Cpt1b | uniprot |
| Acadvl | uniprot |
| Hadha | uniprot |
| Hadhb | uniprot |
| Acadl | uniprot |
| Echs1 | uniprot |
| Hadhsc | uniprot |
| Acadm | uniprot |
| Echs1 | uniprot |
| Hadha | uniprot |
| Hadhsc | uniprot |
| Hadhb | uniprot |
| Acads | uniprot |
| Echs1 | uniprot |
| Acads | uniprot |
| Hadhsc | uniprot |
| Acat1 | uniprot |
| Hadha | uniprot |
| Hadhb | uniprot |
| Dld | uniprot |
| Gcdh | uniprot |
| Lipc | uniprot |
| Lipe | uniprot |
| Lipf | uniprot |
| Pnpla2 | chemical |
| Acas2 | uniprot |
| Beta Oxidation 1 MAPP | |
| Beta Oxidation 2 MAPP | |
| Beta Oxidation 3 MAPP | |
| This MAPP is only present for statistical purpose, | |
| to help evaluate all beta-oxidation MAPPS at once. | |
| Omit the 3 individual sub-mapps from statistical | |
| evaluation to prevent redundancy. |
| Cyp1a1 | uniprot |
| Cyp1a2 | uniprot |
| CYP3A4 | uniprot |
| CYP4A11 | uniprot |
| CYP2A6 | uniprot |
| CYP2D6 | uniprot |
| Cyp2e1 | uniprot |
| ADH1A | uniprot |
| ADH1B | uniprot |
| ADH1C | uniprot |
| Adh4 | uniprot |
| ADH6 | uniprot |
| Adh7 | uniprot |
| Aldh1a1 | uniprot |
| Aldh2 | uniprot |
| CH3-(CH2)10-COO- | |
| HO-CH-(CH2)10-COO- | |
| HOC-(CH2)10-COO- | |
| -OOC-(CH2)10-COO- | |
| Beta Oxidation |
| Pcx | uniprot | |
| Acly | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Acacb | chemical | |
| ACACA | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Acaa2 | uniprot | |
| Hadhsc | uniprot | |
| Ech1 | uniprot | |
| Pecr | uniprot | |
| Scd1 | uniprot | |
| Acsl1 | uniprot | |
| Acsl3 | uniprot | |
| Acsl4 | uniprot | |
| Acas2 | uniprot | |
| Acsl5 | uniprot | |
| Acsl6 | uniprot | |
| Echs1 | uniprot | |
| Echdc2 | ||
| Echdc1 | ||
| Echdc3 | ||
| Nrbf1 | uniprot | |
| Decr1 | uniprot | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Pyruvate | hmdbid:HMDB00243 | |
| TCA Cycle | ||
| Mitochondrion | ||
| Cytosol | ||
| Citrate | hmdbid:HMDB00094 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Acetyl-ACP | chemical | |
| Acetyl-synthase | ||
| Malonyl-CoA | hmdbid:HMDB01175 | |
| Malonyl-ACP | chemical | |
| Acetoacetyl-ACP | chemical | |
| beta-hydroxybutyryl | chemical | |
| Crotonoyl-ACP | chemical | |
| Butyryl-ACP | chemical | |
| less than 6 iterations | ||
| Palmitoyl-ACP | chemical | |
| 6 iterations | ||
| Palmitate | hmdbid:HMDB00220 | |
| 3-ketoacyl-CoA | chemical | |
| 3-L-Hydroxyacyl-CoA | chemical | |
| trans-delta2-enoyl-CoA | chemical | |
| Acyl-CoA (n+2) | ||
| Long-Chain fatty acid | ||
| Fatty acyl CoA | ||
| See Triacylglyceride Synthesis MAPP |
| Thbs4 | uniprot | |
| Tnc | uniprot | |
| Tnr | uniprot | |
| Vtn | uniprot | |
| Vwf | uniprot | |
| Lamc1 | uniprot | |
| Lamc3 | uniprot | |
| Tnn | uniprot | |
| Col5a3 | ||
| Tnxb | ||
| Col4a6 | ||
| Egf | uniprot | |
| Figf | uniprot | |
| Hgf | uniprot | |
| Igf1 | uniprot | |
| Pdgfa | uniprot | |
| Pdgfb | uniprot | |
| Pgf | uniprot | |
| Pelo | uniprot | |
| Itga2 | uniprot | |
| Itga3 | uniprot | |
| Itga4 | uniprot | |
| Itga5 | uniprot | |
| Itga6 | uniprot | |
| Itga7 | uniprot | |
| Itga8 | ||
| Itga9 | ||
| Itga10 | ||
| Itga11 | uniprot | |
| Itga2b | uniprot | |
| Itgae | uniprot | |
| Itgad | uniprot | |
| Itgal | uniprot | |
| Itgam | uniprot | |
| Itgav | uniprot | |
| Itgax | uniprot | |
| Itgb1 | uniprot | |
| Itgb2 | uniprot | |
| Itgb3 | uniprot | |
| Itgb4 | uniprot | |
| Itgb5 | uniprot | |
| Itgb6 | uniprot | |
| Itgb7 | uniprot | |
| Itgb8 | ||
| Rap1a | uniprot | |
| Rap1b | uniprot | |
| Dock1 | uniprot | |
| Shc1 | uniprot | |
| Shc3 | uniprot | |
| Sos1 | uniprot | |
| Zyx | uniprot | |
| Cav | uniprot | |
| Cav3 | uniprot | |
| Fyn | uniprot | |
| Grb2 | uniprot | |
| Vasp | uniprot | |
| Src | uniprot | |
| Ilk | uniprot | |
| Cav2 | uniprot | |
| Actn1 | uniprot | |
| Vcl | uniprot | |
| Chad | ||
| Col11a1 | uniprot | |
| Col11a2 | uniprot | |
| Col2a1 | uniprot | |
| Col3a1 | uniprot | |
| Col4a1 | uniprot | |
| Col4a2 | uniprot | |
| Col4a4 | ||
| Col5a1 | uniprot | |
| Col5a2 | ||
| Col6a2 | uniprot | |
| Col1a1 | uniprot | |
| Col1a2 | uniprot | |
| Comp | uniprot | |
| Fn1 | uniprot | |
| Ibsp | uniprot | |
| Lama2 | uniprot | |
| Lama3 | uniprot | |
| Lama4 | uniprot | |
| Lama5 | uniprot | |
| Lamb1-1 | uniprot | |
| Lamb2 | uniprot | |
| Lamc2 | uniprot | |
| Reln | uniprot | |
| Spp1 | uniprot | |
| Thbs1 | uniprot | |
| Thbs2 | uniprot | |
| Thbs3 | uniprot | |
| Lamb3 | uniprot | |
| Lama1 | uniprot | |
| Blk | uniprot | |
| Egfr | uniprot | |
| Erbb2 | uniprot | |
| Fgr | uniprot | |
| Flt1 | uniprot | |
| Hck | uniprot | |
| Igf1r | uniprot | |
| Kdr | uniprot | |
| Met | ||
| Pdgfra | uniprot | |
| Pdgfrb | uniprot | |
| Ptk6 | uniprot | |
| Srms | uniprot | |
| Txk | uniprot | |
| Tesk2 | uniprot | |
| Styk1 | uniprot | |
| Tnk2 | uniprot | |
| Tnk1 | uniprot | |
| Araf | uniprot | |
| Braf | uniprot | |
| Ha-Ras | uniprot | |
| Raf1 | uniprot | |
| Mapk4 | uniprot | |
| Sepp1 | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Mapk12 | uniprot | |
| Mapk1 | uniprot | |
| Mapk6 | uniprot | |
| Map2k2 | uniprot | |
| Map2k3 | uniprot | |
| Map2k1 | uniprot | |
| Ptk2 | uniprot | |
| Arhgap5 | uniprot | |
| Rhob | uniprot | |
| Farp2 | uniprot | |
| Flna | uniprot | |
| Tln1 | uniprot | |
| Pxn | uniprot | |
| Capn1 | uniprot | |
| Rhoa | uniprot | |
| Pdpk1 | uniprot | |
| Parvb | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Akt3 | uniprot | |
| Rock1 | uniprot | |
| Rock2 | uniprot | |
| Pip5k1c | uniprot | |
| Ppp1r12a | uniprot | |
| Myl6 | uniprot | |
| Mylk | uniprot | |
| Mylk2 | uniprot | |
| Diap1 | uniprot | |
| Actb | uniprot | |
| Actg1 | uniprot | |
| Gsk3b | uniprot | |
| Catnb | uniprot | |
| Pik3ca | uniprot | |
| Pik3cd | uniprot | |
| Pik3r1 | uniprot | |
| Pik3r2 | uniprot | |
| Pik3cg | uniprot | |
| Pik3r5 | uniprot | |
| Pik3r4 | uniprot | |
| Pik3cb | uniprot | |
| Pten | uniprot | |
| Vav1 | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Rac3 | uniprot | |
| Pak1 | uniprot | |
| Pak3 | uniprot | |
| Pak2 | uniprot | |
| Pak4 | uniprot | |
| Pak7 | uniprot | |
| Pak6 | ||
| Elk1 | uniprot | |
| Pdgfc | chemical | |
| Pdgfd | uniprot | |
| Vegfa | uniprot | |
| Vegfb | uniprot | |
| Vegfc | uniprot | |
| Bcar1 | uniprot | |
| Crk | uniprot | |
| Crk1 | uniprot | |
| Rapgef1 | chemical | |
| Braf | uniprot | |
| Bad | ||
| Bcl2 | uniprot | |
| Birc2 | uniprot | |
| Birc3 | uniprot | |
| Birc4 | uniprot | |
| Mapk8 | uniprot | |
| Mapk9 | uniprot | |
| Jun | uniprot | |
| Ccnd1 | uniprot | |
| Ccnd2 | uniprot | |
| Ccnd3 | uniprot | |
| Cdc42 | uniprot | |
| Mapk7 | uniprot | |
| LOC235580 | ||
| Phosphatidylinositiol | chemical | |
| signaling system | ||
| Cell Motility | ||
| Integrin alpha | ||
| Integrin beta | ||
| ITGA | ||
| ITGB | ||
| ECM-receptor interactions | ||
| Cytokine-cytokine receptor interactions | ||
| Receptor Tyrosine Kinases | ||
| RAF | ||
| MEK | hmdbid:HMDB00474 | |
| ERK | enzyme | uniprot |
| PKC | enzyme | uniprot |
| PIP2 | uniprot | |
| PIP3 | uniprot | |
| DNA | CHEBI:16991 | |
| Apoptosis | ||
| Cell Cycle | ||
| DNA | CHEBI:16991 | |
| Cell Proliferation | ||
| Wnt Signaling | ||
| FA turnover | ||
| Regulation of | ||
| actin cytoskeleton | ||
| Actin | uniprot | |
| Polymerization | chemical | |
| Stress Fiber/FA | ||
| formation | ||
| Filopodia | ||
| Lamellipodia | ||
| formation | ||
| Cell Survival | ||
| -p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| -p | ||
| +p | ||
| +p | ||
| -p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p |
| Arhgdig | uniprot | |
| Arhgdib | uniprot | |
| Ppp1cb | uniprot | |
| Rhpn1 | uniprot | |
| Cdc42 | uniprot | |
| Rac1 | uniprot | |
| Rps6kb1 | uniprot | |
| Map3k4 | uniprot | |
| Mapk10 | uniprot | |
| Calm1 | uniprot | |
| Pak3 | uniprot | |
| Cfl1 | uniprot | |
| Mybph | uniprot | |
| Rtkn | uniprot | |
| Rhoa | uniprot | |
| Arhgef1 | uniprot | |
| Gna13 | uniprot | |
| Diap1 | uniprot | |
| Pfn1 | uniprot | |
| Pip5k2a | uniprot | |
| Sh3md2 | ||
| p140 Sra-1 | ||
| Myl1 | uniprot | |
| Pik3r2 | uniprot | |
| Was | ||
| Wasl | uniprot | |
| Iqgap1 | uniprot | |
| Zfp29 | uniprot | |
| Cfl2 | uniprot | |
| Limk1 | uniprot | |
| Cit | uniprot | |
| Tnk2 | uniprot | |
| Rock1 | uniprot | |
| Rock2 | uniprot | |
| Pik3cd | uniprot | |
| Pik3ca | uniprot | |
| Pkn1 | uniprot | |
| 13 | ||
| Activated Rho A | ||
| Cytokinesis | ||
| Actin | uniprot | |
| Membrane | ||
| Ruffling | ||
| Anti-Apoptotic | ||
| Actin Polymerization | ||
| Polymerization | chemical | |
| Filopodia Formation | ||
| Actin Reorganization | ||
| Stress Fiber | ||
| Disappearance | ||
| Disassembly of Actin | ||
| G | ||
| Cell-Cell Adhesion | ||
| Contraction & Actin-Myosin | ||
| Interaction, Focal Adhesion | ||
| Stress Fiber Contraction |
| Gnao1 | uniprot |
| Gnaz | uniprot |
| Gnai1 | uniprot |
| Gnai2 | uniprot |
| Gnai3 | uniprot |
| Gna11 | uniprot |
| Gna14 | uniprot |
| Gna15 | uniprot |
| Gna12 | uniprot |
| Gna13 | uniprot |
| Arhgef1 | uniprot |
| Slc9a1 | uniprot |
| Itpr1 | uniprot |
| Hras1 | uniprot |
| Nras | uniprot |
| Kras | uniprot |
| Rhoa | uniprot |
| Adcy6 | uniprot |
| Adcy7 | uniprot |
| Adcy8 | uniprot |
| Prkar2a | uniprot |
| Prkar2b | uniprot |
| Prkaca | uniprot |
| Adcy9 | uniprot |
| Prkar1a | uniprot |
| Adcy1 | uniprot |
| Adcy3 | uniprot |
| Prkacg | |
| Gnas | uniprot |
| Gnal | uniprot |
| Gnao1 | uniprot |
| Adcy4 | uniprot |
| Adcy5 | uniprot |
| Pde1b | uniprot |
| Pde1c | uniprot |
| Pde4d | uniprot |
| Pde7a | uniprot |
| Pde7b | uniprot |
| Pde8a | uniprot |
| Gnaq | uniprot |
| Prkar1b | uniprot |
| Adcy2 | uniprot |
| Calm1 | uniprot |
| Prkca | uniprot |
| Prkcb1 | uniprot |
| Prkcc | uniprot |
| Prkcd | uniprot |
| Prkci | uniprot |
| Prkch | uniprot |
| Prkcm | uniprot |
| Prkcq | uniprot |
| Prkcz | uniprot |
| Plcb3 | uniprot |
| Ppp3ca | uniprot |
| Ppp3cb | uniprot |
| Ppp3cc | uniprot |
| Gnb1 | uniprot |
| Gnb2 | uniprot |
| Gnb3 | uniprot |
| Gnb4 | uniprot |
| Gnb5 | uniprot |
| Gngt1 | uniprot |
| Gng2 | uniprot |
| Gng3 | uniprot |
| Gng4 | uniprot |
| Gng5 | uniprot |
| Gng7 | uniprot |
| Gng8 | uniprot |
| Pde1a | uniprot |
| Kcnj3 | uniprot |
| Prkce | uniprot |
| Rras | uniprot |
| Prkacb | uniprot |
| Gng11 | uniprot |
| Gng12 | uniprot |
| Gng13 | uniprot |
| Akap1 | uniprot |
| Akap2 | uniprot |
| Akap3 | uniprot |
| Akap4 | uniprot |
| Akap7 | uniprot |
| Akap8 | uniprot |
| Akap9 | |
| Akap10 | uniprot |
| Akap12 | |
| Pde3a | uniprot |
| Pde4b | uniprot |
| Pde10a | chemical |
| cAMP | hmdbid:HMDB00058 |
| IP3 | |
| Ca | |
| ++ | |
| s | |
| G | |
| G | |
| G | |
| q | |
| i | |
| 12/13 | |
| DAG | uniprot |
| Cytoskeletal | |
| Changes | |
| Cell | |
| Response | |
| Cell | |
| Response | |
| Transcription | |
| Transcription | |
| cAMP | hmdbid:HMDB00058 |
| Phosphatase 2B | |
| Protein Kinase A | uniprot |
| Phosphodiesterases | chemical |
| Adenylate Cyclases | uniprot |
| Protein Kinase C | uniprot |
| G | |
| G | |
| beta & gamma | |
| AKAPs |
| Cyp11a1 | uniprot |
| Hsd3b1 | uniprot |
| Cyp11b2 | uniprot |
| Hsd3b1 | uniprot |
| Cyp11b2 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b4 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b2 | uniprot |
| Hsd3b3 | uniprot |
| Hsd3b5 | uniprot |
| (R)20-hydroxysteroid Dh | |
| Cortisone beta-reductase | |
| 20b-Hydroxysteroid Dh | |
| 3a-Hydroxysteroid Dh | |
| 3-Oxo-5b-Steroid Dh | |
| Cyp17a1 | uniprot |
| Cyp21a1 | uniprot |
| Cyp17a1 | uniprot |
| Hsd11b1 | uniprot |
| Hsd11b2 | uniprot |
| Akr1c21 | |
| HO | |
| O | |
| HO | |
| Cholesterol | hmdbid:HMDB00067 |
| From Cholersterol Biosynthesis | |
| Progesterone | hmdbid:HMDB01830 |
| Signaling | |
| Steroid Hormone | CHEBI:26764 |
| Pregnenolone | hmdbid:HMDB00253 |
| 17-a-OH-Pregnenolone | chemical |
| HO | |
| =O | |
| CH | |
| OH | |
| 17-a-OH-Progesterone | chemical |
| and Metabolism | |
| Substrates in | |
| have strucutures shown | |
| 11-Deoxycorticosterone | hmdbid:HMDB00016 |
| C | |
| =O | |
| CH | |
| C | |
| =O | |
| CH | |
| C | |
| O | |
| =O | |
| CH | |
| C | |
| 3 | |
| 3 | |
| 3 | |
| 2 | |
| OH | |
| HO | |
| OH | |
| =O | |
| CH | |
| C | |
| 3 | |
| O | |
| O | |
| =O | |
| CH | |
| C | |
| 2 | |
| OH | |
| HO | |
| OH | |
| 11-Deoxycortisol | hmdbid:HMDB00015 |
| Cortisol | hmdbid:HMDB00063 |
| Cortisone | hmdbid:HMDB02802 |
| 18-Hydroxy-Corticosterone | chemical |
| O | |
| =O | |
| CH | |
| C | |
| 2 | |
| OH | |
| C | |
| O | |
| H | |
| HO | |
| Aldosterone | hmdbid:HMDB00037 |
| 5b-Pregnan-18-al | chemical |
| 3a,11b,21-Trihydroxy-20-Oxo- | chemical |
| 5b-Pregnan-18-al | chemical |
| 11b, 21-Dihydroxy-3,20- | |
| 17a,21-Dihydroxy-5b- | chemical |
| Pregnane-3,11,20-trione | chemical |
| Urocortisone | hmdbid:HMDB00903 |
| Urocortisol | hmdbid:HMDB00949 |
| Cortisol | hmdbid:HMDB00063 |
| Cortolone | hmdbid:HMDB03180 |
| Pregnane 3,20-dione | hmdbid:HMDB03759 |
| 11b,17a 21-Trihydroxy-5b | |
| Glucuronides | hmdbid:HMDB03141 |
| 3a-OH-5b-Pregnane-20-one | chemical |
| 5b-Pregnane-3,20-dione | hmdbid:HMDB03759 |
| HO | |
| CH | |
| C | |
| 3 | |
| H | |
| H | |
| Corticosterone | hmdbid:HMDB01547 |
| -OH | |
| Pregnanediol | hmdbid:HMDB04025 |
| Glucocorticoids | CHEBI:24261 |
| * | |
| * | |
| * | |
| Progesterone Degradation | |
| teal | |
| To Androgen Synthesis | |
| 3B-OH-delta-Steroid Dh |
| 1.8.1.13 | ||
| Anpep | uniprot | |
| Gpx3 | uniprot | |
| 1.8.4.4 | ||
| 1.8.4.1 | ||
| 2.8.1.3 | ||
| 1.8.5.1 | ||
| 1.8.4.3 | ||
| 1.8.3.3 | ||
| 1.11.1.12 | ||
| 1.8.4.7 | ||
| 1.8.4.2 | ||
| 1.5.4.1 | ||
| G6pdx | uniprot | |
| 1.1.1.43 | ||
| Idh1 | uniprot | |
| Gsr | uniprot | |
| Gss | uniprot | |
| Gclc | uniprot | |
| 3.4.11.4 | ||
| Anpep | uniprot | |
| Oplah | uniprot | |
| 2.3.2.4 | ||
| 2.3.2.4 | ||
| 2.3.1.80 | ||
| 6.3.1.8 | ||
| 3.5.1.78 | ||
| Gpx1 | uniprot | |
| Gpx2 | uniprot | |
| Gpx4 | uniprot | |
| MGI:1915562 | ||
| Gstm2 | uniprot | |
| Gstt1 | uniprot | |
| Gstt2 | uniprot | |
| Gstm3 | uniprot | |
| Gclm | uniprot | |
| Ggt1 | uniprot | |
| Ggt1 | uniprot | |
| Ggt1 | uniprot | |
| Gsta5 | uniprot | |
| Gsta2 | uniprot | |
| Ggtla1 | uniprot | |
| Ggtla1 | uniprot | |
| Ggtla1 | uniprot | |
| Glutamate metabolism | ||
| Taurine and hypotaurine | ||
| Cyanoamino | chemical | |
| Cysteine metabolism | ||
| Amino acid metabolism | ||
| L-Amino Acid | CHEBI:15705 | |
| 5-Oxoproline | hmdbid:HMDB00267 | |
| L-Cysteine | hmdbid:HMDB00574 | |
| L-Glutamate | hmdbid:HMDB00148 | |
| Glycine | hmdbid:HMDB00123 | |
| Cysteinyl-Glycine | chemical | |
| (5-L-Glutamyl) | ||
| Glutathione | hmdbid:HMDB00125 | |
| g-L-Glutamyl-L-cysteine | hmdbid:HMDB01049 | |
| Bis-g-glutamylcystine | chemical | |
| Gluthatione | ||
| NADPH | hmdbid:HMDB00221 | |
| NADP+ | hmdbid:HMDB00217 | |
| RX | ||
| R-S-Glutathione | CHEBI:17021 | |
| Glutamylcysteinyl- | chemical | |
| L-Glutamate | hmdbid:HMDB00148 | |
| R-S-Alanyl | chemical | |
| Glycine | hmdbid:HMDB00123 | |
| R-S-Alanine | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| R-S-Mercapturonate | chemical | |
| (reduced) | ||
| glycylspermidine | chemical | |
| glycine | hmdbid:HMDB00123 | |
| metabolism | ||
| acid metabolism | ||
| g-Glutamyl | chemical | |
| Cycle | ||
| -L-amino acid | chemical | |
| glutathione recycling | ||
| Glutathione utilization | ||
| Glutathione | hmdbid:HMDB00125 | |
| utilization | ||
| (oxidized) |
| Pgm1 | uniprot | ||
| Ugp2 | uniprot | ||
| Gyg1 | uniprot | ||
| Gys1 | uniprot | ||
| Gys3 | uniprot | ||
| Branching Enzyme | enzyme | ||
| Debranching Enzyme | enzyme | ||
| Pygm | uniprot | ||
| Gsk3b | uniprot | ||
| Phka1 | uniprot | ||
| Phkg1 | uniprot | ||
| Phkg2 | uniprot | ||
| Ppp2r5e | uniprot | ||
| Ppp2r5c | uniprot | ||
| Ppp2ca | uniprot | ||
| Ppp2cb | uniprot | ||
| Ppp2r4 | uniprot | ||
| Ppp2r3a | uniprot | ||
| Pygl | uniprot | ||
| Phka2 | uniprot | ||
| Ppp2r5d | |||
| Ppp2r1a | uniprot | ||
| Ppp2r2a | uniprot | ||
| Ppp2r5a | uniprot | ||
| Ppp2r5b | |||
| Glycogen | hmdbid:HMDB00757 | ||
| Glucose | hmdbid:HMDB00122 | ||
| Glucose-6-phosphate | hmdbid:HMDB01401 | ||
| Glucose-1-phosphate | hmdbid:HMDB01586 | ||
| Glycogen (n+1) | |||
| UDP-Glucose + | |||
| Glycogen | hmdbid:HMDB00757 | ||
| Glycolysis | |||
| Glycogen (n-1) + Glucose-1-phosphate | |||
| Degradation | |||
| Synthesis | |||
| Phosphorylase Kinase B | |||
| cAMP | hmdbid:HMDB00058 | ||
| Ser/Thr Protein Phosphatase 2A |
| Chrm1 | uniprot | |
| Chrm2 | uniprot | |
| Chrm3 | uniprot | |
| Chrm4 | uniprot | |
| Adra1a | uniprot | |
| Adra1b | uniprot | |
| Adra1d | uniprot | |
| Adra2b | uniprot | |
| Adra2c | uniprot | |
| Adra2a | uniprot | |
| Adrb1 | uniprot | |
| Adrb2 | uniprot | |
| Adrb3 | uniprot | |
| Drd3 | uniprot | |
| Drd4 | uniprot | |
| Hrh1 | uniprot | |
| Hrh2 | uniprot | |
| Htr1b | uniprot | |
| Htr1d | uniprot | |
| Htr1a | uniprot | |
| Htr1f | uniprot | |
| Htr2a | uniprot | |
| Htr2b | uniprot | |
| Htr2c | uniprot | |
| Htr4 | uniprot | |
| Htr5a | uniprot | |
| Htr5b | uniprot | |
| Htr6 | uniprot | |
| Htr7 | uniprot | |
| Agtr1 | uniprot | |
| Agtr1b | uniprot | |
| Agtr2 | uniprot | |
| Nmbr | uniprot | |
| Grpr | uniprot | |
| Brs3 | uniprot | |
| Bdkrb2 | uniprot | |
| Bdkrb1 | uniprot | |
| C3ar1 | uniprot | |
| C5r1 | uniprot | |
| Fpr-rs2 | ||
| Fpr-rs1 | ||
| Fpr1 | uniprot | |
| Fprl1 | uniprot | |
| Fpr-rs4 | ||
| Fpr-rs3 | ||
| Agtrl1 | uniprot | |
| Il8rb | uniprot | |
| Ccr1 | uniprot | |
| Ccr1l1 | uniprot | |
| Ccr2 | uniprot | |
| Ccr3 | uniprot | |
| Ccr4 | uniprot | |
| Ccr5 | uniprot | |
| Ccr6 | uniprot | |
| Ccr8 | uniprot | |
| Ccr9 | uniprot | |
| Ccbp2 | uniprot | |
| Ccrl2 | uniprot | |
| Cxcr3 | uniprot | |
| Cxcr4 | uniprot | |
| Blr1 | uniprot | |
| Cx3cr1 | uniprot | |
| Cckar | uniprot | |
| Cckbr | uniprot | |
| Mc1r | uniprot | |
| Mc2r | uniprot | |
| Mc4r | uniprot | |
| Mc3r | uniprot | |
| Mc5r | uniprot | |
| Npy1r | uniprot | |
| Npy2r | uniprot | |
| Ppyr1 | uniprot | |
| Npy5r | uniprot | |
| Npy6r | uniprot | |
| Gpr83 | uniprot | |
| Ntsr1 | uniprot | |
| Ntsr2 | uniprot | |
| Oprd1 | uniprot | |
| Oprk1 | uniprot | |
| Oprm1 | uniprot | |
| Oprl1 | uniprot | |
| Sstr1 | uniprot | |
| Sstr2 | uniprot | |
| Sstr3 | uniprot | |
| Sstr4 | uniprot | |
| Sstr5 | uniprot | |
| F2r | uniprot | |
| Avpr1a | uniprot | |
| Avpr1b | uniprot | |
| Avp | uniprot | |
| Oxtr | uniprot | |
| Galr1 | uniprot | |
| Galr3 | uniprot | |
| Galr2 | uniprot | |
| F2rl3 | uniprot | |
| F2rl1 | uniprot | |
| F2rl2 | uniprot | |
| Gpr37 | uniprot | |
| Gpr37l1 | uniprot | |
| Gpr33 | uniprot | |
| Cmklr1 | uniprot | |
| Gpr44 | uniprot | |
| Gpr30 | uniprot | |
| Nmur1 | uniprot | |
| Fshr | uniprot | |
| Lhcgr | uniprot | |
| Tshr | uniprot | |
| Rho | uniprot | |
| Opn1mw | uniprot | |
| Opn1sw | uniprot | |
| Rgr | uniprot | |
| Opn4 | uniprot | |
| Rrh | uniprot | |
| Opn3 | uniprot | |
| Olfr19 | uniprot | |
| Olfr1355 | ||
| Olfr870 | ||
| Olfr159 | ||
| Olfr157 | ||
| Olfr156 | ||
| Olfr155 | ||
| Gabbr1 | uniprot | |
| Q9EPG0 | ||
| Olfr71 | ||
| Olfr708 | ||
| Olfr17 | ||
| Q9EPV1 | ||
| Olfr716 | ||
| Olfr715 | ||
| Olfr713 | ||
| Olfr15 | uniprot | |
| Olfr707 | ||
| Olfr714 | ||
| Olfr710 | ||
| Olfr70 | ||
| Q9EQ94 | ||
| Olfr948 | ||
| Olfr971 | ||
| Olfr955 | ||
| Olfr930 | ||
| Olfr148 | uniprot | |
| Olfr933 | ||
| Olfr144 | uniprot | |
| Olfr926 | ||
| Olfr938 | ||
| Olfr943 | ||
| Olfr242 | ||
| Olfr146 | uniprot | |
| Olfr934 | ||
| Olfr959 | ||
| Olfr960 | ||
| Olfr961 | ||
| Olfr143 | uniprot | |
| Olfr968 | ||
| Olfr27 | ||
| Olfr44 | ||
| Olfr970 | ||
| Olfr480 | uniprot | |
| Olfr893 | ||
| Olfr160 | ||
| Olfr957 | ||
| Olfr954 | ||
| Olfr945 | ||
| Olfr937 | ||
| Olfr888 | ||
| Olfr145 | uniprot | |
| Olfr878 | ||
| Olfr874 | ||
| Olfr889 | ||
| Olfr876 | ||
| Olfr887 | ||
| Olfr894 | ||
| Olfr151 | uniprot | |
| Olfr49 | ||
| Olfr749 | ||
| Olfr2 | ||
| Olfr6 | uniprot | |
| Olfr711 | ||
| Olfr16 | ||
| Olfr706 | ||
| Olfr701 | ||
| Olfr705 | ||
| Olfr703 | ||
| Olfr704 | ||
| Ptger1 | uniprot | |
| Ptger2 | uniprot | |
| Ptgdr | uniprot | |
| Ptger3 | uniprot | |
| Ptger4 | uniprot | |
| Ptgfr | uniprot | |
| Ptgir | uniprot | |
| Tbxa2r | uniprot | |
| Adora2a | uniprot | |
| Adora2b | uniprot | |
| Adora3 | uniprot | |
| P2ry2 | uniprot | |
| P2ry1 | uniprot | |
| P2ry6 | uniprot | |
| P2ry4 | uniprot | |
| Gpr35 | uniprot | |
| Ltb4r1 | uniprot | |
| Sucnr1 | uniprot | |
| Cnr2 | uniprot | |
| Cnr1 | uniprot | |
| Ptafr | uniprot | |
| Trhr2 | ||
| Trhr | uniprot | |
| Gpr50 | uniprot | |
| Mtnr1a | uniprot | |
| Gpr87 | uniprot | |
| P2ry12 | uniprot | |
| P2ry13 | uniprot | |
| P2ry14 | uniprot | |
| Gpr27 | uniprot | |
| Mas1 | uniprot | |
| Cmkor1 | uniprot | |
| Tcp10c | chemical | |
| Gpr19 | uniprot | |
| Gpr3 | uniprot | |
| Gpr12 | uniprot | |
| Gpr63 | uniprot | |
| Gpr45 | uniprot | |
| Cysltr1 | uniprot | |
| Gpr65 | uniprot | |
| Gpr34 | uniprot | |
| Gpr109b | uniprot | |
| Ednrb | uniprot | |
| Avpr2 | uniprot | |
| Oxt | uniprot | |
| Olfr944 | ||
| Olfr972 | ||
| Amine | CHEBI:32952 | |
| Acetylcholine (muscarinic) | ||
| Adrenoceptors | ||
| Alpha Adrenoceptors | ||
| Beta Adrenoceptors | ||
| Dopamine | hmdbid:HMDB00073 | |
| Histamine | hmdbid:HMDB00870 | |
| Peptide | CHEBI:16670 CHEBI:16670 | |
| Angiotensin | uniprot | |
| Bombesin | uniprot | |
| Bradykinin | uniprot | |
| C5a anaphylatoxin | uniprot | |
| Fmet-leu-phe | ||
| APJ like | ||
| Interleukin-8 | uniprot | |
| Chemokine | ||
| C-C Chemokine | ||
| C-X-C Chemokine | ||
| CCK | uniprot | |
| Melanocortin | chemical | |
| Neuropeptide Y | uniprot | |
| Neurotensin | uniprot | |
| Opioid | ||
| Somatostatin | ||
| Thrombin | enzyme | uniprot |
| Vasopressin-like | ||
| Galanin | uniprot | |
| Proteinase activated | ||
| GPR37 / endothelin B-like | ||
| Chemokine receptor-like | ||
| Neuromedin U | ||
| Hormone protein | ||
| Follicle stimulating hormone | ||
| Lutropin-choriogonadotropic hormone | ||
| Thyrotropin | ||
| (Rhod)opsin | ||
| Rhodopsin Vertebrate | ||
| Rhodopsin Other | ||
| Olfactory | ||
| Olfactory type 3 | ||
| Prostanoid | CHEBI:26347 | |
| Prostaglandin | CHEBI:26333 | |
| Prostacyclin | hmdbid:HMDB01335 | |
| Thromboxane | hmdbid:HMDB03208 | |
| Nucleotide-like | ||
| Adenosine | hmdbid:HMDB00050 | |
| Purinoceptors | ||
| Cannabis | ||
| Platelet activating factor | ||
| Melatonin | hmdbid:HMDB01389 | |
| Class A Orphan/other | ||
| Thyrotropin-releasing hormone & Secretagogue | ||
| Endothelin |
| Calcrl | uniprot |
| Calcr | uniprot |
| Crhr2 | uniprot |
| Crhr1 | uniprot |
| Gcgr | uniprot |
| Glp1r | uniprot |
| Ghrhr | uniprot |
| Pthr1 | uniprot |
| Adcyap1r1 | uniprot |
| Vipr1 | uniprot |
| Vipr2 | uniprot |
| Cd97 | uniprot |
| Emr1 | uniprot |
| Cd97 | uniprot |
| Calcitonin | uniprot |
| Corticotropin releasing factor | uniprot |
| Glucagon | uniprot |
| Growth hormone-releasing hormone | uniprot |
| Parathyroid hormone | |
| PACAP | uniprot |
| Vasoactive intestinal polypeptide | uniprot |
| EMR1 | uniprot |
| Grm1 | uniprot |
| Grm3 | uniprot |
| Grm8 | uniprot |
| Casr | uniprot |
| V2R2 | |
| V2r1b | uniprot |
| V2r14 | |
| V2r4 | |
| V2r1 | |
| V2r2 | |
| Gabbr1 | uniprot |
| Gprc5d | uniprot |
| Metabotropic glutamate | chemical |
| Extracellular calcium-sensing | |
| Putative pheromone Receptors | |
| GABA-B | |
| Orphan GPRC5 |
| Smo | uniprot | |
| V1ra2 | uniprot | |
| V1ra7 | uniprot | |
| V1ra9 | uniprot | |
| V1ra8 | uniprot | |
| V1ra6 | uniprot | |
| V1ra5 | uniprot | |
| V1ra4 | uniprot | |
| V1ra3 | uniprot | |
| V1ra1 | uniprot | |
| V1rb2 | uniprot | |
| V1rb4 | uniprot | |
| V1rb7 | uniprot | |
| V1rb8 | uniprot | |
| V1rb9 | uniprot | |
| V1rb1 | uniprot | |
| V1rb6 | uniprot | |
| V1rb3 | uniprot | |
| V1rc4 | ||
| V1rc2 | ||
| V1rc1 | ||
| V1rc3 | ||
| V1rc6 | ||
| V1rc7 | ||
| V1RC9 | ||
| V1rc5 | ||
| V1rc8 | ||
| V1rd7 | ||
| V1rd1 | ||
| V1rd2 | ||
| V1rd3 | ||
| V1rd6 | ||
| V1rd14 | ||
| V1rd9 | ||
| V1rd4 | ||
| Gpr132 | uniprot | |
| Gpr73 | uniprot | |
| Ltb4r2 | uniprot | |
| Gpr84 | uniprot | |
| Mrgprh | uniprot | |
| Gpr146 | uniprot | |
| Grca | ||
| Dfy | uniprot | |
| Gpr88 | uniprot | |
| Cysltr1 | uniprot | |
| Celsr2 | uniprot | |
| Celsr1 | uniprot | |
| Gpr115 | uniprot | |
| Gpr56 | uniprot | |
| Drd2 | uniprot | |
| Gpr143 | uniprot | |
| Olfr154 | uniprot | |
| Xcr1 | uniprot | |
| Gpr2 | uniprot | |
| Ccr7 | uniprot | |
| Adora1 | uniprot | |
| Adora3 | uniprot | |
| Drd1a | uniprot | |
| Edg5 | uniprot | |
| Ednra | uniprot | |
| Gpr7 | uniprot | |
| Mc4r | uniprot | |
| Grm1 | uniprot | |
| Tacr3 | uniprot | |
| Fzd1 | uniprot | |
| Fzd5 | uniprot | |
| V2r3 | ||
| V2r5 | ||
| V2r6 | ||
| V2r7 | ||
| Gprc2a-rs1 | ||
| Gprc2a-rs2 | ||
| Gprc2a-rs3 | ||
| Sstr5 | uniprot | |
| Olfr1355 | ||
| Olfr1353 | ||
| Calcr | uniprot | |
| Casr | uniprot | |
| Olfr10 | uniprot | |
| Olfr11 | uniprot | |
| Olfr12 | uniprot | |
| Olfr13 | uniprot | |
| Olfr7 | uniprot | |
| Olfr1 | uniprot | |
| Olfr3 | uniprot | |
| Olfr5 | uniprot | |
| Olfr6 | uniprot | |
| Olfr8 | uniprot | |
| Olfr9 | uniprot | |
| Mtnr1b | uniprot | |
| Oprk1 | uniprot | |
| Olfr4 | uniprot | |
| Q61071 | ||
| Drd5 | uniprot | |
| Htr1d | uniprot | |
| Htr1a | uniprot | |
| Olfr32 | ||
| Olfr20 | ||
| Olfr30 | ||
| Olfr28 | ||
| Olfr19 | uniprot | |
| Olfr25 | ||
| Olfr33 | ||
| Olfr18 | ||
| Olfr22-ps1 | ||
| Olfr24 | ||
| Olfr29-ps1 | ||
| Olfr31 | ||
| Olfr27 | ||
| Olfr26 | ||
| Htr1da | ||
| Htr1db | ||
| Gpr37l1 | uniprot | |
| Oprm1 | uniprot | |
| Edg8 | uniprot | |
| Edg1 | uniprot | |
| Cnr1 | uniprot | |
| Adrb2 | uniprot | |
| Ghsr | uniprot | |
| Tas1r1 | uniprot | |
| Adrb1 | uniprot | |
| Gpr34 | uniprot | |
| Olfr701 | ||
| Fzd7 | uniprot | |
| Cd97 | uniprot | |
| Rrh | uniprot | |
| 6530406P05Rik | chemical | |
| Gpr39 | uniprot | |
| Gpr83 | uniprot | |
| Q9EPV2 | ||
| Olfr395 | ||
| Olfr397 | ||
| Olfr23 | ||
| Q9EPY6 | ||
| Q9EPY8 | ||
| Olfr402 | ||
| Olfr410 | ||
| Olfr412 | ||
| Trhr2 | ||
| Q9ERW4 | ||
| Irx6 | uniprot | |
| Q9ERX0 | ||
| Q9ERX4 | ||
| Q9ERX6 | ||
| Q9ERY0 | ||
| Q9ERY2 | ||
| Olfr394 | ||
| Q9ERY7 | ||
| Celsr3 | uniprot | |
| Q9ESF9 | ||
| Olfr2 | ||
| Q9ESG1 | ||
| Q9JHH0 | ||
| Q9JHK3 | ||
| Fzd2 | uniprot | |
| Q9JM17 | ||
| Q9JM18 | ||
| Q9JM19 | ||
| Olfr161 | ||
| Q9JM21 | ||
| Q9JM22 | ||
| Q9JM23 | ||
| Q9JM24 | ||
| Q9JM25 | ||
| Q9JM26 | ||
| Q9JM27 | ||
| Q9JM28 | ||
| Q9JM29 | ||
| Q9JM30 | ||
| Q9JM31 | ||
| Q9JM33 | ||
| Q9JM34 | ||
| Olfr403 | ||
| Q9JM36 | ||
| Q9JM37 | ||
| Olfr382 | ||
| Q9JM39 | ||
| Q9JM40 | ||
| Q9JM41 | ||
| Q9JM42 | ||
| Oprl1 | uniprot | |
| Opn1lw | ||
| Pthr2 | uniprot | |
| Fzd9 | uniprot | |
| Q9WU87 | ||
| Olfr642 | ||
| Olfr586 | ||
| Gabbr1 | uniprot | |
| Olfr138 | ||
| Olfr62 | ||
| Olfr61 | ||
| Olfr60 | ||
| Olfr59 | ||
| Olfr58 | ||
| Olfr56 | ||
| Olfr57 | ||
| Olfr55 | ||
| Olfr54 | ||
| Olfr53 | ||
| Olfr52 | ||
| Olfr51 | ||
| Olfr50 | ||
| Olfr48 | ||
| Olfr47 | ||
| Olfr46 | ||
| Olfr45 | ||
| Olfr44 | ||
| Olfr43 | uniprot | |
| Olfr42 | ||
| Vipr1 | uniprot | |
| Smoothened | ||
| Vomeronasal receptors (V1R & V3R) | ||
| Putative / unclassified GPCRs | ||
| Other Chemokine Receptors | ||
| Fragments |
| Ptch2 | uniprot |
| Shh | |
| Cdc2a | uniprot |
| Ptch1 | uniprot |
| Ptch2 | uniprot |
| Dhh | uniprot |
| Smo | uniprot |
| Ihh | uniprot |
| Ptch1 | uniprot |
| Ptch2 | uniprot |
| Ihh | uniprot |
| Gli3 | uniprot |
| Ski | |
| Sufu | uniprot |
| Sap18 | uniprot |
| Sin3a | uniprot |
| Gli1 | uniprot |
| Gas1 | uniprot |
| Crebbp | uniprot |
| Dyrk1a | uniprot |
| Gli2 | chemical |
| Stk36 | uniprot |
| Sufu | uniprot |
| Cdc2a | uniprot |
| CCNB1 | uniprot |
| Gli1 | uniprot |
| Gli2 | chemical |
| Gli3 | uniprot |
| Ptch1 | uniprot |
| Sufu | uniprot |
| Rab23 | uniprot |
| Rab23 | uniprot |
| CCNB1 | uniprot |
| Smo | uniprot |
| Igf2 | uniprot |
| Dhh | uniprot |
| Shh | |
| Shh | |
| Dhh | uniprot |
| Ihh | uniprot |
| Shh | |
| Hhip | uniprot |
| Hhip | uniprot |
| Hhip | uniprot |
| Ptch1 | uniprot |
| Translocation | |
| Plasma membrane | |
| Cytoplasm | |
| Endosome | |
| Nucleus | CHEBI:33252 |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| PM->EN | |
| CY->NU | |
| CY->PM | |
| PM->EN | |
| Molecular Association | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| Gene Symbol | |
| Activation | chemical |
| D | |
| Inhibition | chemical |
| Accession Number: NetPath_10; cellmap:10 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| EN | |
| NU | |
| D | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Methylation | chemical |
| Demethylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Extracellular | |
| EC | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Palmitoylation | chemical |
| Glycosylation |
| Map3k1 | uniprot |
| Casp8 | uniprot |
| Casp3 | uniprot |
| Fadd | uniprot |
| Bid | |
| Casp2 | uniprot |
| Casp6 | uniprot |
| Casp7 | uniprot |
| Hspa1a | uniprot |
| Fas | uniprot |
| Casp8 | uniprot |
| Pdcd8 | uniprot |
| Cycs | uniprot |
| Apaf1 | uniprot |
| Casp9 | |
| Cycs | uniprot |
| Nfkb1 | uniprot |
| Hspa1a | uniprot |
| Hspa1a | uniprot |
| Fadd | uniprot |
| Tnfrsf1a | uniprot |
| Ripk1 | uniprot |
| Mapk10 | uniprot |
| TNF-alpha | uniprot |
| STRESS | |
| Mitochondria | |
| APOPTOSIS | |
| CELL SURVIVAL | |
| Ik alpha | |
| degradation of | |
| Activation | chemical |
| of proteins | |
| degradation | |
| (activation of NFkB) | |
| Inhibition | chemical |
| Apoptosome | |
| Inhibition | chemical |
| NF-kB | |
| FAS-Ligand | |
| Proteasome | enzyme |
| pathway | |
| Inhibition | chemical |
| Inhibition | chemical |
| Zfhx1a | uniprot |
| Myog | uniprot |
| Il1a | uniprot |
| ? | |
| Eif4e | uniprot |
| Atf3 | uniprot |
| Ifng | uniprot |
| Dusp14 | uniprot |
| Nr4a3 | uniprot |
| MINOR | uniprot |
| Wdr1 | uniprot |
| Jund1 | uniprot |
| Il1r1 | uniprot |
| Cyr61 | uniprot |
| Gdf8 | uniprot |
| Eif4ebp1 | uniprot |
| Vegfa | uniprot |
| Il18 | uniprot |
| Adam10 | uniprot |
| Ifrd1 | uniprot |
| Ankrd1 | uniprot |
| Hbegf | uniprot |
| -634 | |
| -698 | |
| +1 | |
| ? | |
| angiogenesis | |
| protein synthesis | |
| proliferative response | |
| +500 | |
| +296 | |
| correlate to all 4 MINOR probes | |
| HB-EGF correlated |
| Id1 | uniprot | |
| Id2 | uniprot | |
| Id3 | uniprot | |
| Id4 | uniprot | |
| Id2 | uniprot | |
| Rb1 | uniprot | |
| Rbl2 | uniprot | |
| Rbl1 | uniprot | |
| Tcfe2a | uniprot | |
| Myod1 | uniprot | |
| CDK2 | uniprot | |
| Ccna2 | uniprot | |
| Ccne1 | uniprot | |
| Elk1 | uniprot | |
| Elk4 | uniprot | |
| Elk3 | uniprot | |
| Psmd4 | uniprot | |
| Hes1 | uniprot | |
| Pax5 | uniprot | |
| Pax2 | uniprot | |
| Pax8 | uniprot | |
| Myf5 | uniprot | |
| Myf6 | uniprot | |
| Myog | uniprot | |
| Tcf12 | uniprot | |
| Srebf1 | uniprot | |
| Msc | uniprot | |
| IFI16 | uniprot | |
| Bmp2 | uniprot | |
| Bmpr2 | uniprot | |
| Vegfa | uniprot | |
| Flt1 | uniprot | |
| Kdr | uniprot | |
| Smad1 | uniprot | |
| Smad4 | uniprot | |
| Smad5 | uniprot | |
| Atf3 | uniprot | |
| Smad3 | uniprot | |
| Tgif | uniprot | |
| Acvrl1 | uniprot | |
| Smad4 | uniprot | |
| Smad5 | uniprot | |
| Smad1 | uniprot | |
| TCR | ||
| LCK | uniprot | |
| RAS | uniprot | |
| MAPK | enzyme | uniprot |
| ERK | enzyme | uniprot |
| Igf1r | uniprot | |
| Igf1 | uniprot | |
| Irs1 | uniprot | |
| PI3K | uniprot | |
| Ctnnb1 | uniprot | |
| Tert | uniprot | |
| Nfkb1 | uniprot | |
| Rela | uniprot | |
| Bmp6 | uniprot | |
| Cd40lg | uniprot | |
| Ngfb | uniprot | |
| Atf3 | uniprot | |
| Smad3 | uniprot | |
| Egf | uniprot | |
| Tcf7l2 | uniprot | |
| Gene Symbol | ||
| ID Gene Regulation | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| Control | ||
| Ligand | ||
| Receptor | ||
| Molecule in the Pathway | ||
| P | ||
| P | ||
| P | ||
| CY -> NU | ||
| Cytoplasm | ||
| Extracellular | ||
| Proteins in a complex interaction | ||
| Molecular association | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| Phosphorylation | chemical | |
| Activation | chemical | |
| Translocation | ||
| CY | ||
| EC | ||
| Accession Number: NetPath_5; cellmap:5 | ||
| Enzyme complex | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Sumoylation | chemical | |
| Desumoylation | ||
| Ubiquitination | ||
| Deubiquitination | ||
| Inhibition | chemical | |
| Recruitment | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi apparatus | ||
| Mitochondria | ||
| MT | ||
| Nucleus | CHEBI:33252 | |
| NU | ||
| PM | ||
| Plasma membrane |
| Il1b | uniprot | |
| Il1rn | uniprot | |
| Il1rap | uniprot | |
| Il1r1 | uniprot | |
| Il1a | uniprot | |
| Il1b | uniprot | |
| Il1rn | uniprot | |
| Il1r2 | uniprot | |
| Il1r2 | uniprot | |
| Il1rap | uniprot | |
| Il1r2 | uniprot | |
| Myd88 | uniprot | |
| Irak1 | uniprot | |
| Il1r1 | uniprot | |
| Il1r1 | uniprot | |
| Irak1 | uniprot | |
| Traf6 | uniprot | |
| Irak1 | uniprot | |
| Traf6 | uniprot | |
| Traf6 | uniprot | |
| Irak1 | uniprot | |
| Traf6 | uniprot | |
| Sirpa | uniprot | |
| Il1a | uniprot | |
| Irak2 | chemical | |
| Irak1 | uniprot | |
| Il1a | uniprot | |
| Il1b | uniprot | |
| Sirpa | uniprot | |
| Irak1 | uniprot | |
| Traf6 | uniprot | |
| Traf6 | uniprot | |
| Gene Symbol | ||
| Il1a | uniprot | |
| Il1b | uniprot | |
| CAPN1 | uniprot | |
| CAPNS1 | uniprot | |
| CASP1 | uniprot | |
| SQSTM1 | uniprot | |
| PTPN11 | uniprot | |
| PTPN11 | uniprot | |
| IRAK3 | uniprot | |
| IRAK4 | uniprot | |
| IRAK4 | uniprot | |
| Irak4 | uniprot | |
| PLCG1 | uniprot | |
| MAPK1 | uniprot | |
| MAPK1 | uniprot | |
| AKT1 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAPK8 | uniprot | |
| CHUK | enzyme | uniprot |
| CHUK | enzyme | uniprot |
| MAP2K1 | uniprot | |
| MAPK3 | uniprot | |
| TOLLIP | uniprot | |
| TOLLIP | uniprot | |
| PELI1 | uniprot | |
| PELI1 | uniprot | |
| MAP3K14 | uniprot | |
| MAP3K14 | uniprot | |
| IKBKAP | uniprot | |
| RELA | uniprot | |
| RELA | uniprot | |
| NFKBIA | uniprot | |
| NFKBIA | uniprot | |
| NFKBIB | uniprot | |
| NFKB1 | uniprot | |
| PRKCZ | uniprot | |
| D | ||
| CY -> NU | ||
| PM -> CY | ||
| PM -> CY | ||
| D | ||
| D | ||
| Accession Number: NetPath_13 | ||
| D | ||
| Receptor | ||
| Ligand | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| Enzyme complex | ||
| Molecular association | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| Phosphorylation | chemical | |
| Autophosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Palmitoylation | chemical | |
| Ubiquitination | ||
| Proteolytic cleavage | ||
| Glycosylation | ||
| Acetylation | chemical | |
| Sumoylation | chemical | |
| Methylation | chemical | |
| Recruitment | ||
| Activation | chemical | |
| Inhibition | chemical | |
| Translocation | ||
| PM | ||
| Plasma membrane | ||
| CY | ||
| Cytoplasm | ||
| NU | ||
| Nucleus | CHEBI:33252 | |
| EN | ||
| Endosome | ||
| GO | ||
| Golgi apparatus | ||
| MT | ||
| Mitochondria | ||
| CY->EX | ||
| CY->EX | ||
| Deubiquitination | ||
| Deacetylation | chemical | |
| Desumoylation | ||
| Demethylation | chemical | |
| EC | ||
| Extracellular | ||
| D | ||
| D | ||
| D | ||
| CY -> NU | ||
| CY -> NU | ||
| Control |
| Il2rg | uniprot |
| Il2rb | uniprot |
| Il2ra | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Jak1 | uniprot |
| Jak3 | uniprot |
| Jak2 | uniprot |
| Lck | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Ptpn6 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Gab2 | uniprot |
| Syk | uniprot |
| Irs1 | uniprot |
| Irs2 | uniprot |
| Stam2 | uniprot |
| Stam | uniprot |
| Socs3 | uniprot |
| Plcb1 | uniprot |
| RPS6KB1 | uniprot |
| Pik3ca | uniprot |
| Pik3cb | uniprot |
| Pik3cd | uniprot |
| Pik3cg | uniprot |
| Fyn | uniprot |
| Akt1 | uniprot |
| Foxo3a | |
| Tert | uniprot |
| Lyn | |
| Ptpn11 | uniprot |
| Shc1 | uniprot |
| Raf1 | uniprot |
| Grb2 | uniprot |
| Ptk2b | uniprot |
| Cd53 | uniprot |
| Icam1 | uniprot |
| Sos1 | uniprot |
| Socs1 | uniprot |
| Cish | uniprot |
| Gnb2l1 | uniprot |
| Crkl | uniprot |
| Cbl | uniprot |
| Shb | uniprot |
| Crk | uniprot |
| Nmi | uniprot |
| Ets1 | uniprot |
| Ets2 | uniprot |
| Nr3c1 | uniprot |
| Prkcz | uniprot |
| Itm2b | uniprot |
| Bcl2 | uniprot |
| IFNA1 | uniprot |
| Frap1 | uniprot |
| Hsp90aa1 | uniprot |
| Mknk1 | uniprot |
| Eif4e | uniprot |
| Creb1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Vav1 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Ybx1 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Ybx1 | uniprot |
| Tert | uniprot |
| Akt1 | uniprot |
| Raf1 | uniprot |
| Kras | uniprot |
| Mapk8 | uniprot |
| Mapk14 | uniprot |
| Mapkapk2 | uniprot |
| Mapk9 | uniprot |
| Chuk | uniprot |
| Eif3s9 | uniprot |
| Akt1 | uniprot |
| Stat3 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Stat1 | uniprot |
| Crk | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Molecular association | |
| Translocation | |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| Inhibition | chemical |
| Activation | chemical |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> PM | |
| CY -> NU | |
| PM -> CY | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| D | |
| D | |
| D | |
| Gene Symbol | |
| Accession Number: NetPath_14 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Reactions through unknown mechanisms/molecules | |
| Plasma membrane | |
| Nucleus | CHEBI:33252 |
| (Protein-protein interaction) | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitolyation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Sumoylation | chemical |
| Recruitment | |
| Control | |
| CY | |
| EC | |
| EN | |
| ER | |
| GO | |
| MT | |
| MT | |
| PM | |
| Cytoplasm | |
| Extracellular | |
| Endoplasmic reticulum | |
| Endosome | |
| Golgi apparatus | |
| Mitochondrion | |
| NU | |
| NU | |
| Nucleus | CHEBI:33252 |
| IL3 | uniprot |
| Il3ra | uniprot |
| IL3 | uniprot |
| IL3 | uniprot |
| CSF2RB | uniprot |
| Il3ra | uniprot |
| CSF2RB | uniprot |
| Pik3ca | uniprot |
| Pik3cd | uniprot |
| Hras1 | uniprot |
| Tec | uniprot |
| Vav1 | uniprot |
| Jak1 | uniprot |
| Jak2 | uniprot |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Lyn | |
| Syk | uniprot |
| Hck | uniprot |
| Fyn | uniprot |
| Lck | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Stat6 | uniprot |
| Stat5b | uniprot |
| Stat3 | uniprot |
| RARA | uniprot |
| Rxra | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Akt1 | uniprot |
| Ywhaz | uniprot |
| Fes | uniprot |
| Cish | uniprot |
| Gnb2l1 | uniprot |
| Prkcb1 | uniprot |
| Shc1 | uniprot |
| Ywhaq | uniprot |
| Ywhab | uniprot |
| Gab2 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Inpp5d | |
| Gab1 | uniprot |
| Rapgef1 | chemical |
| Crkl | uniprot |
| Cbl | uniprot |
| Crk | uniprot |
| PILRB | uniprot |
| Bad | |
| Bcl2l1 | uniprot |
| Bcl2 | uniprot |
| Bax | uniprot |
| Bcl2l11 | uniprot |
| Ppp2ca | uniprot |
| Creb1 | uniprot |
| Ptk2 | uniprot |
| Pxn | uniprot |
| Src | uniprot |
| Socs2 | uniprot |
| Socs3 | uniprot |
| Dnm1 | uniprot |
| Vcl | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Rac1 | uniprot |
| Rac2 | uniprot |
| Mapk8 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Gata1 | uniprot |
| Gata2 | uniprot |
| Prkaca | uniprot |
| Pak1 | uniprot |
| Shc1 | uniprot |
| Prkca | uniprot |
| Prkca | uniprot |
| Nfkb1 | uniprot |
| Nfkb1 | uniprot |
| Slc2a1 | uniprot |
| Slc2a1 | uniprot |
| Bad | |
| Mapk3 | uniprot |
| Tyk2 | uniprot |
| Gsk3a | uniprot |
| Gsk3b | uniprot |
| Kcnip3 | uniprot |
| Mapk7 | uniprot |
| Foxo1 | uniprot |
| Hspb1 | uniprot |
| Mapk14 | uniprot |
| Atf2 | uniprot |
| ATF1 | uniprot |
| Mras | uniprot |
| Kras | uniprot |
| Rps6kb2 | uniprot |
| Rap1a | uniprot |
| Birc5 | uniprot |
| Mapkapk2 | uniprot |
| Sfpi1 | uniprot |
| Cdc42 | uniprot |
| Bmx | uniprot |
| Tnfrsf1b | uniprot |
| Id1 | uniprot |
| Selp | uniprot |
| Fcer2a | uniprot |
| Mapk9 | uniprot |
| Chek1 | uniprot |
| Matk | uniprot |
| Mmp2 | uniprot |
| Mmp9 | uniprot |
| Gene Symbol | |
| IL3 | uniprot |
| Molecular Association | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| D | |
| CY->PM | |
| CY->NU | |
| CY->PM | |
| CY->NU | |
| D | |
| D | |
| Activation | chemical |
| Plasma membrane | |
| CY->PM | |
| D | |
| MT->CY | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Mitochondrion | |
| Accession Number: NetPath_15 | |
| Molecule in the pathway | |
| Receptor | |
| Ligand | |
| Proteins in a complex interaction | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| Translocation | |
| Inhibition | chemical |
| PM | |
| CY | |
| NU | |
| MT | |
| Enzyme complex | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Dephosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Deacetylation | chemical |
| Acetylation | chemical |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA |
| Il2rg | uniprot |
| Il4ra | uniprot |
| Il4 | uniprot |
| Fes | uniprot |
| Inpp5d | |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Jak1 | uniprot |
| Irs1 | uniprot |
| Il4 | uniprot |
| Il4ra | uniprot |
| Il13ra1 | uniprot |
| Jak2 | uniprot |
| Tyk2 | uniprot |
| Jak1 | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Prkcz | uniprot |
| Stat6 | uniprot |
| Pawr | uniprot |
| Irs2 | uniprot |
| Jak3 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Cxcr4 | uniprot |
| Adrbk2 | uniprot |
| Ptk2 | uniprot |
| Shc1 | uniprot |
| Plcg1 | uniprot |
| HIST2H3C | uniprot |
| Crebbp | uniprot |
| Ep300 | |
| Mapk14 | uniprot |
| Mapk11 | uniprot |
| Atf2 | uniprot |
| Cbl | uniprot |
| Stat6 | uniprot |
| Stat6 | uniprot |
| Stat5a | uniprot |
| Socs5 | uniprot |
| Stat6 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Mapk14 | uniprot |
| Dok2 | uniprot |
| Rasa1 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Bad | |
| NCF1 | uniprot |
| Pik3ca | uniprot |
| Pik3cd | uniprot |
| Bcl2l1 | uniprot |
| Socs1 | uniprot |
| RPS6KB1 | uniprot |
| Hmga1 | uniprot |
| Ets1 | uniprot |
| Socs3 | uniprot |
| Stat1 | uniprot |
| Src | uniprot |
| Elk1 | uniprot |
| Akt1 | uniprot |
| Prkcd | uniprot |
| Prkcn | uniprot |
| Prkci | uniprot |
| Prkcd | uniprot |
| Prkcn | uniprot |
| Prkci | uniprot |
| Prkcz | uniprot |
| Nfkb1 | uniprot |
| Sfpi1 | uniprot |
| Lck | uniprot |
| Fyn | uniprot |
| Stam | uniprot |
| Stat6 | uniprot |
| Jak2 | uniprot |
| Gene Symbol | |
| Translocation | |
| Cytoplasm | |
| Plasma membrane | |
| Nucleus | CHEBI:33252 |
| CY -> NU | |
| D | |
| D | |
| D | |
| D | |
| CY -> PM | |
| CY -> PM | |
| CY -> PM | |
| CY -> PM | |
| CY -> NU | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| D | |
| Inhibition | chemical |
| D | |
| Accession Number: NetPath_16 | |
| Proteins in a complex interaction | |
| Molecular association | |
| Reaction through unknown mechanisms/molecules | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Activation | chemical |
| (Protein-protein interaction) | |
| Acetylation | chemical |
| PM | |
| CY | |
| NU | |
| Enzyme complex | |
| Autophosphorylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Control |
| Il5 | uniprot |
| Il5 | uniprot |
| Il5ra | uniprot |
| CSF2RB | uniprot |
| Shc1 | uniprot |
| Ptpn11 | uniprot |
| CSF2RB | uniprot |
| Dnm2 | uniprot |
| Prkcb1 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| SHC2 | uniprot |
| Mapk14 | uniprot |
| Nfkbia | uniprot |
| Ptk2b | uniprot |
| Pik3cg | uniprot |
| Map2k2 | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Ptpn6 | uniprot |
| Nfkb1 | uniprot |
| Mapk9 | uniprot |
| Grb2 | uniprot |
| Lyn | |
| Unc119 | uniprot |
| Crkl | uniprot |
| Raf1 | uniprot |
| Kras | uniprot |
| Syk | uniprot |
| Sdcbp | uniprot |
| Sox4 | uniprot |
| Socs1 | uniprot |
| Ywhaz | uniprot |
| Hck | uniprot |
| Akt1 | uniprot |
| Rps6ka1 | uniprot |
| Foxo3a | |
| Nfkb1 | uniprot |
| Gsk3a | uniprot |
| Pla2g4a | uniprot |
| Vav1 | uniprot |
| Hcls1 | uniprot |
| Cbl | uniprot |
| Aps | uniprot |
| Jun | uniprot |
| Btk | uniprot |
| Gsk3b | uniprot |
| Atf2 | uniprot |
| Elk1 | uniprot |
| Il2rb | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Crkl | uniprot |
| Alox5 | uniprot |
| Alox5 | uniprot |
| Bax | uniprot |
| Bax | uniprot |
| Prkcd | uniprot |
| Prkcd | uniprot |
| Il5ra | uniprot |
| CSF2RB | uniprot |
| Ctnnb1 | uniprot |
| Ctnnb1 | uniprot |
| Hras1 | uniprot |
| Rap1gap | |
| Ccnd3 | uniprot |
| Cdkn1b | uniprot |
| Rapgef1 | chemical |
| Alox5ap | uniprot |
| Rac1 | uniprot |
| Icam1 | uniprot |
| ICAM3 | uniprot |
| Itgb2 | uniprot |
| Itgam | uniprot |
| Pim1 | uniprot |
| Jak1 | uniprot |
| Jak2 | uniprot |
| Stat3 | uniprot |
| Stat1 | uniprot |
| Stat5b | uniprot |
| Stat5a | uniprot |
| (Protein-protein interaction) | |
| Translocation | |
| Autophosphorylation | chemical |
| Recruitment | |
| Inhibition | chemical |
| Activation | chemical |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Plasma membrane | |
| Control | |
| Ubiquitination | |
| Mitochondria | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->MT | |
| CY->PM | |
| PM->NU | |
| PM->NU | |
| PM->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| Gene Symbol | |
| D | |
| Accession Number: NetPath_17 | |
| Molecular association | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| NU | |
| MT | |
| D | |
| D | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO |
| Il6 | uniprot |
| Il6ra | uniprot |
| Il6ra | uniprot |
| Il6st | uniprot |
| Il6st | uniprot |
| Fes | uniprot |
| Tec | uniprot |
| Btk | uniprot |
| Jak2 | uniprot |
| Ptpn11 | uniprot |
| Jak1 | uniprot |
| Tyk2 | uniprot |
| Shc1 | uniprot |
| Grb2 | uniprot |
| Stat3 | uniprot |
| Sos1 | uniprot |
| Vav1 | uniprot |
| Mapk1 | uniprot |
| Gab1 | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Stat1 | uniprot |
| Stat1 | uniprot |
| Stat1 | uniprot |
| Stat3 | uniprot |
| Stat1 | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Mapk14 | uniprot |
| Mapk14 | uniprot |
| Sgk | uniprot |
| Sgk | uniprot |
| Nfkb1 | uniprot |
| Nfkb1 | uniprot |
| Nlk | uniprot |
| Hras1 | uniprot |
| Ncoa1 | uniprot |
| Crebbp | uniprot |
| Rac1 | uniprot |
| Cdk9 | uniprot |
| Daxx | uniprot |
| Ar | |
| Hdac1 | uniprot |
| Prkcd | uniprot |
| Ptk2b | uniprot |
| Gab2 | uniprot |
| Map2k4 | uniprot |
| Hsp90aa1 | uniprot |
| Socs3 | uniprot |
| Fos | uniprot |
| Jun | uniprot |
| Tcf1 | uniprot |
| Cebpb | uniprot |
| Erbb2 | uniprot |
| Erbb3 | uniprot |
| Hck | uniprot |
| Lyn | |
| Cebpb | uniprot |
| Raf1 | uniprot |
| Casp3 | uniprot |
| Casp9 | |
| Ppp2ca | uniprot |
| Ppp2cb | uniprot |
| Ppp2r1a | uniprot |
| Ppp2r1b | uniprot |
| Ppp2r2a | uniprot |
| Ppp2r2b | uniprot |
| Ppp2r2c | uniprot |
| 3222402P14Rik | chemical |
| PPP2R3B | uniprot |
| Ppp2r4 | uniprot |
| Ppp2r5a | uniprot |
| Ppp2r5b | |
| Ppp2r5c | uniprot |
| Ppp2r5d | |
| Ppp2r5e | uniprot |
| Ep300 | |
| Map2k6 | uniprot |
| Cdk5 | uniprot |
| MAPT | uniprot |
| Rps6ka2 | uniprot |
| Mapk3 | uniprot |
| Fgr | uniprot |
| Plcg1 | uniprot |
| Map3k4 | uniprot |
| Rb1 | uniprot |
| Akt1 | uniprot |
| Bad | |
| Gsk3b | uniprot |
| Foxo1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Eif4e | uniprot |
| Eif2a | uniprot |
| Mapk8 | uniprot |
| Ptk2 | uniprot |
| Pxn | uniprot |
| Foxo3a | |
| Mllt7 | uniprot |
| Inpp5d | |
| Inppl1 | |
| RPS6KB1 | uniprot |
| Eif4ebp1 | uniprot |
| Bmx | uniprot |
| Fyn | uniprot |
| Cd40 | uniprot |
| Stat3 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Mapkapk2 | uniprot |
| Map3k7 | uniprot |
| Map3k7 | uniprot |
| Hspb1 | uniprot |
| Il6 | uniprot |
| Cdk5r1 | uniprot |
| Autophosphorylation | chemical |
| Early Endosomes | |
| Inhibition | chemical |
| Translocation | |
| Cytoplasm | |
| CY->NU | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Acetylation | chemical |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY->EN | |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| CY->NU | |
| Activation | chemical |
| Complex formation | |
| Gene Symbol | |
| D | |
| D | |
| Accession Number: NetPath_18 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-Protein interaction) | |
| D | |
| Reactions through unknown mechanisms/molecules | |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| CY | |
| Extracellular | |
| EC | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| NU | |
| Nucleus | CHEBI:33252 |
| PM | |
| Plasma membrane | |
| Molecular association |
| IL7 | uniprot |
| Il7r | uniprot |
| Jak3 | uniprot |
| Il2rg | uniprot |
| Jak1 | uniprot |
| Fyn | uniprot |
| Lyn | |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Stat3 | uniprot |
| PIK3R1 | uniprot |
| Ptk2b | uniprot |
| Irs1 | uniprot |
| Irs2 | uniprot |
| Akt1 | uniprot |
| Stat1 | uniprot |
| Stam2 | uniprot |
| Stam | uniprot |
| Bax | uniprot |
| Bad | |
| Foxo3a | |
| Gsk3b | uniprot |
| Foxo1 | uniprot |
| Rb1 | uniprot |
| Ccnd2 | uniprot |
| Ccna2 | uniprot |
| Cdk4 | uniprot |
| CDK2 | uniprot |
| Cltc | uniprot |
| Bcl2l11 | uniprot |
| Mcl1 | uniprot |
| Blk | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Cblb | uniprot |
| Shc1 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Cbl | uniprot |
| Irf1 | uniprot |
| Muc1 | uniprot |
| Gene Symbol | |
| Hras1 | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| D | |
| D | |
| D | |
| PM | |
| CY | |
| NU | |
| EN | |
| GO | |
| MT | |
| Plasma membrane | |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| Molecular association | |
| Reaction through unknown mechanisms/molecules | |
| Phosphorylation | chemical |
| Autophosphorylation | chemical |
| Dephosphorylation | chemical |
| Palmitoylation | chemical |
| Ubiquitination | |
| Proteolytic cleavage | |
| Glycosylation | |
| Acetylation | chemical |
| Sumoylation | chemical |
| Methylation | chemical |
| Recruitment | |
| Activation | chemical |
| Inhibition | chemical |
| Translocation | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Endosome | |
| Golgi apparatus | |
| Mitochondrion | |
| Accession Number: NetPath_19 | |
| EC | |
| Extracellular | |
| Deacetylation | chemical |
| Demethylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Control |
| Il9 | uniprot |
| Il9r | uniprot |
| Il2rg | uniprot |
| Irs1 | uniprot |
| PIK3R1 | uniprot |
| Irs2 | uniprot |
| Grb2 | uniprot |
| Htatip | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Jak1 | uniprot |
| Vcp | uniprot |
| Jak3 | uniprot |
| Map2k2 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Map2k1 | uniprot |
| Shc1 | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Akt1 | uniprot |
| Ptpn11 | uniprot |
| Tyk2 | uniprot |
| Socs3 | uniprot |
| Molecular association | |
| CY->NU | |
| Translocation | |
| CY | |
| NU | |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| D | |
| Reaction through unknown mechanisms/molecules | |
| D | |
| D | |
| D | |
| Inhibition | chemical |
| Receptor | |
| Ligand | |
| Activation | chemical |
| Accession Number: NetPath_20 | |
| Gene Symbol | |
| Molecule in the pathway | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Proteins in a complex interaction | |
| Proteins in a complex interaction | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| PM | |
| Plasma membrane | |
| (Protein-protein interaction) |
| H2-Eb1 | uniprot |
| Il10ra | uniprot |
| Fcgr1 | uniprot |
| Mmp2 | uniprot |
| Tnf | uniprot |
| Lta | uniprot |
| Il1a | uniprot |
| Il1b | uniprot |
| Il6 | uniprot |
| Fn1 | uniprot |
| Lama5 | uniprot |
| Lamb1-1 | uniprot |
| Lamc1 | uniprot |
| Lamb2 | uniprot |
| Lamc2 | uniprot |
| Vtn | uniprot |
| Col3a1 | uniprot |
| Col1a1 | uniprot |
| Col1a2 | uniprot |
| Il5ra | uniprot |
| Tnfsf5 | uniprot |
| Cd80 | uniprot |
| Cd86 | uniprot |
| Tnfrsf5 | uniprot |
| Cd28 | uniprot |
| Tnfrsf1a | uniprot |
| Tnfrsf1b | uniprot |
| Lck | uniprot |
| Zap70 | uniprot |
| Il2ra | uniprot |
| Il2rb | uniprot |
| Il2rg | uniprot |
| Il2 | uniprot |
| Il4 | uniprot |
| Il5 | uniprot |
| Ifng | uniprot |
| Thbs3 | uniprot |
| Thbs1 | uniprot |
| Il4ra | uniprot |
| Igh-Ia | |
| Igh-6 | |
| B-cell | |
| TH-cell | |
| Fibroblast | |
| Blood or Lymph | |
| Epithelium | |
| Macrophage | |
| Inflammation | |
| Early Response | |
| Fibrotic Response |
| Insr | uniprot | |
| Igf1r | uniprot | |
| Irs1 | uniprot | |
| Irs2 | uniprot | |
| Irs4 | chemical | |
| Pik3ca | uniprot | |
| Pik3cb | uniprot | |
| Pik3cg | uniprot | |
| Pik3cd | uniprot | |
| Pik3r1 | uniprot | |
| Pik3r2 | uniprot | |
| Pik3r3 | uniprot | |
| Pik3r4 | uniprot | |
| Pik3c2a | uniprot | |
| Pik3c3 | uniprot | |
| Pik3c2g | uniprot | |
| Pdpk1 | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Gsk3b | uniprot | |
| Gsk3a | uniprot | |
| Slc2a4 | uniprot | |
| Pten | uniprot | |
| Prkci | uniprot | |
| Prkcz | uniprot | |
| Pscd3 | uniprot | |
| Arf6 | uniprot | |
| Arf1 | uniprot | |
| Inpp4a | uniprot | |
| Trib3 | uniprot | |
| Foxo1 | uniprot | |
| Pfkm | uniprot | |
| Gys1 | uniprot | |
| Gab1 | uniprot | |
| Shc1 | uniprot | |
| Shc2 | uniprot | |
| Grb2 | uniprot | |
| Ptpn11 | uniprot | |
| Sos1 | uniprot | |
| Sos2 | uniprot | |
| Raf1 | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Map2k3 | uniprot | |
| Map2k4 | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Map3k1 | uniprot | |
| Map3k2 | uniprot | |
| Map3k3 | uniprot | |
| Map3k4 | uniprot | |
| Mapk3 | uniprot | |
| Mapk4 | uniprot | |
| Mapk1 | uniprot | |
| Mapk6 | uniprot | |
| Mapk13 | uniprot | |
| Mapk9 | uniprot | |
| Mapk10 | uniprot | |
| Map4k1 | uniprot | |
| Map3k5 | uniprot | |
| Map3k10 | ||
| Mapk8 | uniprot | |
| Mapk14 | uniprot | |
| Map3k8 | uniprot | |
| Map3k12 | uniprot | |
| Map4k2 | uniprot | |
| Map3k7 | uniprot | |
| Map3k11 | ||
| Map2k7 | ||
| Mapk11 | uniprot | |
| Map3k9 | ||
| Map4k4 | uniprot | |
| Mapk7 | uniprot | |
| Map3k13 | ||
| Map4k3 | uniprot | |
| Map3k6 | ||
| Mink1 | uniprot | |
| Mapk12 | uniprot | |
| Map4k5 | uniprot | |
| Map3k14 | uniprot | |
| Rps6kb1 | uniprot | |
| Rps6ka2 | uniprot | |
| Rps6ka3 | uniprot | |
| Rps6kb2 | uniprot | |
| Rps6ka1 | uniprot | |
| Rps6ka5 | uniprot | |
| Rps6ka6 | ||
| Rps6ka4 | uniprot | |
| Irs3 | chemical | |
| Ppp1cc | uniprot | |
| Ptprf | ||
| Cbl | uniprot | |
| Cblb | uniprot | |
| Cblc | uniprot | |
| Rapgef1 | chemical | |
| Cap1 | uniprot | |
| Sorbs1 | uniprot | |
| Rhoj | uniprot | |
| Snx26 | uniprot | |
| Rhoq | uniprot | |
| Crk | uniprot | |
| Flot1 | uniprot | |
| Flot2 | uniprot | |
| MGI:1345171 | ||
| Ptpn1 | uniprot | |
| Frap1 | uniprot | |
| Eif4e | uniprot | |
| Eif4ebp1 | uniprot | |
| Lipe | uniprot | |
| Gys2 | uniprot | |
| Egr1 | uniprot | |
| Fos | uniprot | |
| Jun | uniprot | |
| Slc2a1 | uniprot | |
| Grb10 | uniprot | |
| Shc3 | uniprot | |
| Hras1 | uniprot | |
| Rrad | uniprot | |
| Inppl1 | ||
| Prkca | uniprot | |
| Prkcb1 | uniprot | |
| Prkcq | uniprot | |
| Prkch | uniprot | |
| Prkcd | uniprot | |
| Enpp1 | uniprot | |
| Gyg1 | uniprot | |
| Pfkl | uniprot | |
| Tsc1 | uniprot | |
| Rheb | uniprot | |
| Tsc2 | uniprot | |
| Rab4a | uniprot | |
| Stxbp4 | uniprot | |
| Vamp2 | uniprot | |
| Snap25 | uniprot | |
| Snap23 | uniprot | |
| Ehd1 | uniprot | |
| Ehd2 | uniprot | |
| Myo1c | uniprot | |
| Kif5b | uniprot | |
| Kif3a | uniprot | |
| Sgk | uniprot | |
| Sgk2 | uniprot | |
| Sgkl | uniprot | |
| Foxo3a | ||
| Tbc1d4 | uniprot | |
| Elk1 | uniprot | |
| Srf | uniprot | |
| Grb14 | uniprot | |
| Stxbp1 | uniprot | |
| Stxbp2 | uniprot | |
| Stxbp3 | uniprot | |
| Stx4a | uniprot | |
| Mapk8 | uniprot | |
| Socs1 | uniprot | |
| Socs3 | uniprot | |
| Prkaa1 | uniprot | |
| Prkaa2 | uniprot | |
| Ikbkb | uniprot | |
| Xbp1 | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Glucose Transport | ||
| Modulators of Insulin Action | ||
| MEK/MAP Kinases | ||
| Insulin Receptor Substrates | ||
| PI 3-Kinase | ||
| p90 Rsk Kinases | ||
| Transcriptional Regulators & Immediate Early Genes | ||
| Vesicular Trafficking | ||
| p70 S6 Kinases | ||
| Metabolic Regulation | ||
| Ras-MAPK Signaling | ||
| PDK/Akt Signaling | ||
| Tor Signaling | ||
| Translation Regulation |
| Cdc42 | uniprot | |
| Shc1 | uniprot | |
| Shc3 | uniprot | |
| Araf | uniprot | |
| Braf | uniprot | |
| Mapk4 | uniprot | |
| Mapk7 | uniprot | |
| Arhgef7 | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Rac3 | uniprot | |
| Pdpk1 | uniprot | |
| Vav2 | uniprot | |
| Vav3 | uniprot | |
| Sos1 | uniprot | |
| Zyx | uniprot | |
| Cav1 | uniprot | |
| Cav3 | uniprot | |
| Fyn | uniprot | |
| Grb2 | uniprot | |
| Sepp1 | uniprot | |
| Ha-Ras | uniprot | |
| Ptk2 | uniprot | |
| Ptk2 | uniprot | |
| Rho | uniprot | |
| Csk | uniprot | |
| Bcar1 | uniprot | |
| Src | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| MYO-P | ||
| MYO | ||
| Capn2 | uniprot | |
| Capn11 | ||
| Capn6 | uniprot | |
| Pak3 | uniprot | |
| Pak6 | ||
| Vasp | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Mapk12 | uniprot | |
| Rapgef1 | chemical | |
| Mapk1 | uniprot | |
| Mapk6 | uniprot | |
| Map2k2 | uniprot | |
| Pelo | uniprot | |
| Itga2 | uniprot | |
| Itga3 | uniprot | |
| Itga4 | uniprot | |
| Itga5 | uniprot | |
| Itga6 | uniprot | |
| Itga7 | uniprot | |
| Itga8 | ||
| Itga9 | ||
| Itga10 | ||
| Itga11 | uniprot | |
| Itga2b | uniprot | |
| Itgae | uniprot | |
| Itgad | uniprot | |
| Itgal | uniprot | |
| Itgam | uniprot | |
| Itgav | uniprot | |
| Itgax | uniprot | |
| Itgb1 | uniprot | |
| Itgb2 | uniprot | |
| Itgb3 | uniprot | |
| Itgb4 | uniprot | |
| Itgb5 | uniprot | |
| Itgb6 | uniprot | |
| Itgb7 | uniprot | |
| Itgb8 | ||
| Src | uniprot | |
| Mapk10 | uniprot | |
| Ilk | uniprot | |
| Cav2 | uniprot | |
| Capn3 | uniprot | |
| Capn9 | uniprot | |
| Actn1 | uniprot | |
| Git2 | uniprot | |
| Akt3 | uniprot | |
| Capns1 | uniprot | |
| Rap1a | uniprot | |
| Rap1b | uniprot | |
| Raf1 | uniprot | |
| Tln1 | uniprot | |
| Sorbs1 | uniprot | |
| Crk | uniprot | |
| Dock1 | uniprot | |
| PI5K | ||
| Pik3r2 | uniprot | |
| p110 | uniprot | |
| Rock1 | uniprot | |
| Rock2 | uniprot | |
| Mylk2 | uniprot | |
| Capn1 | uniprot | |
| Capn5 | uniprot | |
| Capn7 | uniprot | |
| Capn10 | uniprot | |
| Pak2 | uniprot | |
| Pak1 | uniprot | |
| Pak4 | uniprot | |
| Map2k3 | uniprot | |
| Map2k1 | uniprot | |
| Vcl | uniprot | |
| Tns | ||
| Pxn | uniprot | |
| CAPN | uniprot | |
| PI3K | uniprot | |
| Phosphatidylinositiol | chemical | |
| signaling system | ||
| C3G | uniprot | |
| F-actin | chemical | |
| p130 Cas | ||
| MEK | hmdbid:HMDB00474 | |
| ERK | enzyme | uniprot |
| PAK | ||
| F-actin | chemical | |
| cell motility | ||
| cell maintenance | ||
| cell maintenance | ||
| RAF | ||
| CAPN | uniprot | |
| PAK | ||
| ECM | uniprot | |
| Integrin alpha | ||
| Integrin beta | ||
| ITGA | ||
| ITGB | ||
| cell proliferation |
| Ces2 | uniprot |
| Ces1 | uniprot |
| Irinotecan | chemical |
| SN-38 | |
| CYP3A4 | uniprot |
| CYP3A5 | uniprot |
| M4 | |
| APC | uniprot |
| NPC | uniprot |
| CYP3A4 | uniprot |
| CYP3A5 | uniprot |
| CYP3A4 | uniprot |
| Ces1 | uniprot |
| Ces2 | uniprot |
| SN-38 | |
| Ugt1a1 | uniprot |
| Ugt1a9 | |
| Abcc1 | uniprot |
| Abcc2 | uniprot |
| SN-38 | |
| Ces1 | uniprot |
| Ces2 | uniprot |
| Abcc1 | uniprot |
| Abcc2 | uniprot |
| Abcg2 | uniprot |
| Ugt1a6 | uniprot |
| Ugt1a1 | uniprot |
| Ugt1a10 | |
| SN-38G | |
| Ces2 | uniprot |
| Ces1 | uniprot |
| Bche | uniprot |
| Abcc2 | uniprot |
| Ugt1a6 | uniprot |
| Abcc1 | uniprot |
| SN-38 | |
| Irinotecan | chemical |
| Irinotecan | chemical |
| Neutropenia | |
| Liver Cell | |
| Diarrhea | |
| Intestine | |
| Model human liver cell showing blood, bile and | |
| intestinal compartments, indicating tissue | |
| involvment of genes in the irinotecan pathway. |
| Grb7 | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Shc1 | uniprot |
| CSF2RB | uniprot |
| Mpdz | uniprot |
| Grb2 | uniprot |
| Socs6 | uniprot |
| Socs4 | uniprot |
| Socs5 | uniprot |
| Cish | uniprot |
| Cltc | uniprot |
| Crk | uniprot |
| Src | uniprot |
| Plce1 | uniprot |
| Jak2 | uniprot |
| Grap | uniprot |
| Ptpru | |
| AI586015 | |
| Prkca | uniprot |
| Plcg1 | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Pik3cg | uniprot |
| Aps | uniprot |
| Grb10 | uniprot |
| Akt1 | uniprot |
| Tec | uniprot |
| Lyn | |
| Dok1 | uniprot |
| Dok1 | uniprot |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Epor | uniprot |
| Rps6ka1 | uniprot |
| Mitf | uniprot |
| Mapk1 | uniprot |
| Abl1 | uniprot |
| Inpp5d | |
| Fgr | uniprot |
| Hck | uniprot |
| Yes1 | uniprot |
| Rasa1 | uniprot |
| Fes | uniprot |
| Crkl | uniprot |
| Cbl | uniprot |
| Socs1 | uniprot |
| Vav1 | uniprot |
| Vav2 | uniprot |
| Matk | uniprot |
| Bad | |
| Sos1 | uniprot |
| Ep300 | |
| Fyn | uniprot |
| Prkcb1 | uniprot |
| Hras1 | uniprot |
| Raf1 | uniprot |
| Spred2 | uniprot |
| Spred1 | uniprot |
| Sh3kbp1 | uniprot |
| Cblb | uniprot |
| Tnfrsf10b | uniprot |
| Btk | uniprot |
| Kit | |
| Kitl | uniprot |
| Kit | |
| Kitl | uniprot |
| Map2k1 | uniprot |
| Stat3 | uniprot |
| p85 complex | |
| Molecular association | |
| Phosphorylation | chemical |
| Activation | chemical |
| Translocation | |
| Inhibition | chemical |
| Autophosphorlation | |
| Dephosphorylation | chemical |
| Plasma Membrane | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| CY->PM | |
| Accession Number: NetPath_6; cellmap:6 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| (Protein-protein interaction) | |
| D | |
| PM | |
| CY | |
| NU | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion |
| Pdha1 | uniprot | |
| Pdha2 | uniprot | |
| Pdhb | uniprot | |
| Dlat | uniprot | |
| Dld | uniprot | |
| Pdhx | uniprot | |
| Pdk2 | uniprot | |
| Pdk3 | uniprot | |
| Pdk4 | uniprot | |
| 4930402E16Rik | ||
| Pcx | uniprot | |
| Mdh1 | uniprot | |
| Mdh2 | uniprot | |
| Cs | ||
| Aco2 | uniprot | |
| Fh1 | uniprot | |
| Idh3a | uniprot | |
| Idh3b | ||
| Idh3g | uniprot | |
| Idh2 | uniprot | |
| Sdha | uniprot | |
| Sdhb | uniprot | |
| Sdhc | uniprot | |
| Sdhd | uniprot | |
| Ogdh | uniprot | |
| Dlst | uniprot | |
| Dld | uniprot | |
| Suclg1 | uniprot | |
| Suclg2 | uniprot | |
| Sucla2 | uniprot | |
| Pyruvate | hmdbid:HMDB00243 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Succinate | hmdbid:HMDB00254 | |
| Malate | hmdbid:HMDB03256 | |
| alpha-Ketogluterate | chemical | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Fumarate | hmdbid:HMDB00134 | |
| Malate | hmdbid:HMDB03256 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Isocitrate | hmdbid:HMDB00193 | |
| Fatty Acid Synthesis | ||
| Glycolysis | ||
| Gluconeogenesis | chemical | |
| Degradation of Fatty Acids | ||
| Containing an Odd Number of Carbons | ||
| Electron Transport Chain | ||
| Degradation of Fatty Acids | ||
| Containing an Even Number of Carbons | ||
| Citrate | hmdbid:HMDB00094 | |
| Succinyl-CoA | hmdbid:HMDB01022 | |
| Mitochondrion | ||
| Cytosol |
| Hras1 | uniprot |
| Kras | uniprot |
| Nras | uniprot |
| Rras | uniprot |
| Plcb3 | uniprot |
| Map3k1 | uniprot |
| Map3k2 | uniprot |
| Map3k3 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Mapk3 | uniprot |
| Mapk1 | uniprot |
| Jun | uniprot |
| Map2k3 | uniprot |
| Map2k4 | uniprot |
| Braf | uniprot |
| Map2k6 | uniprot |
| Mbp | uniprot |
| Mtap2 | uniprot |
| Elk1 | uniprot |
| Sipa1 | uniprot |
| Mapk14 | uniprot |
| Map2k7 | |
| Raf1 | uniprot |
| Araf | uniprot |
| Rasa3 | uniprot |
| RapGAPII | chemical |
| Mapk10 | uniprot |
| Map3k12 | uniprot |
| Mapk12 | uniprot |
| GDP | hmdbid:HMDB01201 |
| Activated | |
| GTP | hmdbid:HMDB01273 |
| G | |
| i | |
| G | |
| q | |
| and G | |
| g | |
| b | |
| G | |
| Stress Activated Pathways | |
| p38 MAPK Pathway | |
| Growth and Mitogenesis | |
| Apoptosis | |
| Nucleus | CHEBI:33252 |
| Rap1GAP | uniprot |
| Tmem37 | uniprot | |
| Ntrk1 | uniprot | |
| Egfr | uniprot | |
| fgfr | ||
| Pdgfrb | uniprot | |
| Ngfb | uniprot | |
| Bdnf | uniprot | |
| Ntf5 | uniprot | |
| Egf | uniprot | |
| Fgf4 | uniprot | |
| Pdgfb | uniprot | |
| Grb2 | uniprot | |
| Sos2 | uniprot | |
| Kras | uniprot | |
| Nras | uniprot | |
| Mras | uniprot | |
| Gna12 | uniprot | |
| Gap1m | ||
| Rasgrf2 | ||
| Rasgrp4 | ||
| Rasgrp1 | ||
| Nf1 | uniprot | |
| Rasa1 | uniprot | |
| Prkcd | uniprot | |
| Prkcc | uniprot | |
| Prkcb1 | uniprot | |
| Prkcz | uniprot | |
| Prkch | uniprot | |
| Prkcd | uniprot | |
| Il1r2 | uniprot | |
| Il1r1 | uniprot | |
| Fas | uniprot | |
| Tgfbr1 | uniprot | |
| Acvr1b | uniprot | |
| Tgfbr1 | uniprot | |
| Tgfbr2 | uniprot | |
| Cd14 | uniprot | |
| Tnf | uniprot | |
| Il1a | uniprot | |
| Il1b | uniprot | |
| Fasl | uniprot | |
| Tgfb3 | uniprot | |
| Tgfb1 | uniprot | |
| Tgfb2 | uniprot | |
| Gadd45a | uniprot | |
| traf6 | uniprot | |
| tab2 | uniprot | |
| ecsit | chemical | |
| Daxx | uniprot | |
| tab1 | uniprot | |
| traf2 | uniprot | |
| Casp1 | uniprot | |
| Casp3 | uniprot | |
| Casp9 | ||
| Casp7 | uniprot | |
| Casp8 | uniprot | |
| Casp2 | uniprot | |
| Casp6 | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Cdc42 | uniprot | |
| Braf | uniprot | |
| Raf1 | uniprot | |
| Mos | uniprot | |
| Prkaca | uniprot | |
| Rap1b | uniprot | |
| Rap1a | uniprot | |
| Map4k3 | uniprot | |
| hgk | ||
| hpk1 | uniprot | |
| Pak1 | uniprot | |
| Pak2 | uniprot | |
| Stk3 | uniprot | |
| mink | ||
| gck | uniprot | |
| Map3k8 | uniprot | |
| Map3k1 | uniprot | |
| mlk3 | ||
| Map3k3 | uniprot | |
| lzk | ||
| Map3k12 | uniprot | |
| mltk | uniprot | |
| ask2 | ||
| Map3k5 | uniprot | |
| Map3k7 | uniprot | |
| mekk4 | uniprot | |
| Taok1 | uniprot | |
| Taok2 | uniprot | |
| Ppm1b | uniprot | |
| Map2k5 | uniprot | |
| Mapk7 | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Mapk1 | uniprot | |
| Mapk3 | uniprot | |
| Mapk4 | uniprot | |
| Mapk6 | uniprot | |
| mp1 | uniprot | |
| Ptpn7 | uniprot | |
| Ptpn5 | uniprot | |
| Ptprr | uniprot | |
| Dusp1 | uniprot | |
| Dusp6 | uniprot | |
| Gm337 | ||
| Dusp7 | uniprot | |
| Dusp4 | uniprot | |
| Dusp10 | uniprot | |
| nik | uniprot | |
| Ikbkg | uniprot | |
| Ikbkb | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Akt3 | uniprot | |
| Ppp5c | uniprot | |
| mkk3 | uniprot | |
| Map2k6 | uniprot | |
| Ppm1a | uniprot | |
| Mapk13 | uniprot | |
| Mapk12 | uniprot | |
| Mapk14 | uniprot | |
| Nfkb1 | uniprot | |
| Mapt | uniprot | |
| Stmn1 | uniprot | |
| Pla2g5 | uniprot | |
| Pla2g10 | uniprot | |
| mnk1/2 | ||
| rsk2 | uniprot | |
| Atf4 | uniprot | |
| elk-1 | chemical | |
| Sap1a | chemical | |
| Myc | uniprot | |
| SRF | uniprot | |
| Fos | uniprot | |
| Ppp3cc | uniprot | |
| Ppp3ca | uniprot | |
| Ppp3cb | uniprot | |
| Ppp3r1 | uniprot | |
| Ppp3r2 | uniprot | |
| mkk7 | ||
| mkk4 | ||
| Mapk8 | uniprot | |
| Mapk10 | uniprot | |
| Mapk9 | uniprot | |
| Mapk8ip1 | uniprot | |
| Ptpn7 | uniprot | |
| Ptpn5 | uniprot | |
| Ptprr | uniprot | |
| flna | uniprot | |
| Mapk8ip3 | uniprot | |
| Arrb1 | uniprot | |
| Arrb2 | uniprot | |
| Crk | uniprot | |
| Crkl | uniprot | |
| Hspa8 | uniprot | |
| Hspa1a | uniprot | |
| Hspa5 | uniprot | |
| Jun | uniprot | |
| Jund1 | uniprot | |
| nfat2/4 | ||
| Atf2 | uniprot | |
| Elk-1 | chemical | |
| Trp53 | uniprot | |
| sap1a | chemical | |
| Ddit3 | uniprot | |
| Max | ||
| mef2c | uniprot | |
| Hspb2 | uniprot | |
| Hspb1 | uniprot | |
| Atf4 | uniprot | |
| Nr4a1 | uniprot | |
| prak | ||
| Mapkapk2 | uniprot | |
| msk1/2 | ||
| Cdc25b | uniprot | |
| nlk | uniprot | |
| Classical MAP kinase Pathway | ||
| Ca2+ | CHEBI:29108 | |
| DAG | uniprot | |
| LPS | CHEBI:16412 | |
| DNA damage | ||
| JNK & p38 MAP kinase pathway | ||
| Serum, cytotoxic drugs, irradiation, | ||
| heatshock, reactive oxy species | ||
| LPS and other stress | ||
| Integrin-mediated | ||
| cell adhesion | ||
| cAMP | hmdbid:HMDB00058 | |
| IP3 | ||
| Heteromeric G-protein | ||
| Phosphatidylinositol | chemical | |
| signaling system | ||
| MAPKKKK | ||
| ERK5 pathway | ||
| Serum, EGF, | ||
| reactive oxygen species, | ||
| or Srk tyrosinkinase | ||
| downstream | ||
| PTP | uniprot | |
| MKP | ||
| p38 | uniprot | |
| Proliferation, inflammation, anti-apoptosis | ||
| DNA | CHEBI:16991 | |
| DNA | CHEBI:16991 | |
| Proliferation, | ||
| differentiation | ||
| JNK | enzyme | uniprot |
| PTP | uniprot | |
| MAPKKK | enzyme | uniprot |
| MAPKK | enzyme | uniprot |
| MAPK | enzyme | uniprot |
| Transcription factors | ||
| DNA | CHEBI:16991 | |
| Alzheimer’s disease | ||
| Wnt signaling | ||
| DNA | CHEBI:16991 | |
| Apoptosis | ||
| Proliferation, differentiation, | ||
| inflammation | ||
| DNA | CHEBI:16991 | |
| Proliferation, differentiation | ||
| Cell | ||
| Cycle | ||
| pathway |
| Timp3 | uniprot |
| Timp2 | uniprot |
| Timp4 | uniprot |
| Mmp1a | uniprot |
| Mmp8 | uniprot |
| Mmp13 | uniprot |
| Mmp2 | uniprot |
| Mmp9 | uniprot |
| Mmp3 | uniprot |
| Mmp11 | uniprot |
| Mmp7 | uniprot |
| Mmp12 | uniprot |
| Mmp10 | uniprot |
| Mmp14 | uniprot |
| Mmp15 | uniprot |
| Mmp16 | uniprot |
| Mmp17 | uniprot |
| Mmp19 | uniprot |
| Mmp20 | uniprot |
| Mmp24 | uniprot |
| Mmp23 | uniprot |
| Mmp25 | |
| Mmp22 | |
| Timp1 | uniprot |
| Bsg | uniprot |
| Tcf20 | uniprot |
| Tnf | uniprot |
| Gelatinases | |
| Collagenases | |
| Stromelysins | chemical |
| Membrane-type MMPs | |
| Matrilysin | enzyme |
| Inhibitors | |
| Enamelysin | uniprot |
| Other | |
| Potential Inducers of Transcription | |
| Metalloelastase | enzyme |
| Based on Vu & Werb (2000) | |
| Matrix metalloproteinases: effectors of | |
| development and normal physiology. | |
| Genes Dev 14:2123-2133 |
| Acadl | uniprot | |
| Cpt2 | uniprot | |
| Acadm | uniprot | |
| Acsl1 | uniprot | |
| Pecr | uniprot | |
| Dci | uniprot | |
| Scp2 | uniprot | |
| Ehhadh | uniprot | |
| Acads | uniprot | |
| Acadvl | uniprot | |
| Cpt1a | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Acsl3 | uniprot | |
| Acsl4 | uniprot | |
| Slc25a20 | uniprot | |
| Long chain Acyl-CoA | ||
| Long chain Acyl-CoA | ||
| trans- | chemical | |
| 3-Ketoacyl-CoA | chemical | |
| saturated | ||
| unsaturated | ||
| mitochondrial matrix | ||
| cytosol | ||
| -Enoyl-CoA | chemical | |
| Acyl-CoA (n-2) | ||
| 2,4 Dienoyl-CoA | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| D | ||
| 2 | ||
| 3-L-Hydroxyacyl-CoA | chemical | |
| Long chain acyl-carnitine | ||
| Long chain acyl-carnitine | ||
| cis- | chemical | |
| D- | ||
| -Enoyl-CoA | chemical | |
| 3 | ||
| Acyl-CoA dehydrogenases: | ||
| Long Chain Fatty Acid |
| Drd2 | uniprot |
| Drd3 | uniprot |
| Drd4 | uniprot |
| Drd5 | uniprot |
| Htr1a | uniprot |
| Htr1b | uniprot |
| Htr1d | uniprot |
| Drd1a | uniprot |
| Htr1f | uniprot |
| Htr2a | uniprot |
| Htr2b | uniprot |
| Htr2c | uniprot |
| Htr4 | uniprot |
| Htr5a | uniprot |
| Htr5b | uniprot |
| Htr6 | uniprot |
| Htr7 | uniprot |
| Adra1a | uniprot |
| Adra1b | uniprot |
| Adra1d | uniprot |
| Adra2a | uniprot |
| Adra2b | uniprot |
| Adra2c | uniprot |
| Adrb1 | uniprot |
| Adrb2 | uniprot |
| Adrb3 | uniprot |
| Admr | uniprot |
| Hrh1 | uniprot |
| Hrh2 | uniprot |
| Chrm4 | uniprot |
| Chrm1 | uniprot |
| Chrm2 | uniprot |
| Chrm3 | uniprot |
| Htr1d | uniprot |
| Chrm5 | uniprot |
| Dopamine | hmdbid:HMDB00073 |
| Adrenergic | |
| Serotonin | hmdbid:HMDB00259 |
| Gi/Go Pathway | |
| Gq/G11 Pathway | |
| Gs Pathway | |
| Gs Pathway | |
| Muscarinic Ach | |
| Histamine | hmdbid:HMDB00870 |
| Receptors | |
| Receptors | |
| Receptors | |
| Receptors | |
| Receptors |
| Hnrpa1 | uniprot | |
| Hnrpa2b1 | uniprot | |
| Hnrpab | uniprot | |
| Hnrpc | uniprot | |
| Hnrpk | uniprot | |
| Hnrpl | uniprot | |
| Fusip1 | uniprot | |
| Snrpd1 | uniprot | |
| Snrpd2 | uniprot | |
| Snrpe | uniprot | |
| Snrpf | uniprot | |
| Snrpg | uniprot | |
| Cstf1 | uniprot | |
| Cstf2 | uniprot | |
| Cpsf3 | uniprot | |
| Cpsf1 | uniprot | |
| Cpsf2 | uniprot | |
| Cstf2t | uniprot | |
| Pabpn1 | uniprot | |
| Lsm2 | uniprot | |
| Prpf18 | uniprot | |
| Sfrs1 | uniprot | |
| Clk1 | uniprot | |
| Clk4 | uniprot | |
| U2af2 | uniprot | |
| Snrpn | uniprot | |
| Polr2a | uniprot | |
| Supt5h | uniprot | |
| Rnmt | uniprot | |
| Rngtt | uniprot | |
| Ncbp1 | uniprot | |
| Ncbp2 | uniprot | |
| Mettl3 | uniprot | |
| Hnrpa3 | uniprot | |
| Hnrpd | uniprot | |
| Rbmxrt | uniprot | |
| Hnrph1 | uniprot | |
| Hnrph2 | uniprot | |
| Hnrpu | ||
| Hnrpm | uniprot | |
| Ptbp1 | uniprot | |
| Snrp70 | uniprot | |
| Snrpa | uniprot | |
| Snrpb | uniprot | |
| Smc1l1 | uniprot | |
| Cd2bp2 | uniprot | |
| Nsep1 | uniprot | |
| Dhx9 | uniprot | |
| Snrpd3 | uniprot | |
| Sfrs8 | ||
| Sfrs14 | uniprot | |
| Sfrs12 | uniprot | |
| Sfrs16 | uniprot | |
| Fus | uniprot | |
| Sf4 | uniprot | |
| Rbm5 | uniprot | |
| Cpsf5 | uniprot | |
| Cpsf4 | uniprot | |
| MGI:1336880 | ||
| 2610031L17Rik | ||
| 0610009C03Rik | ||
| Txnl4 | uniprot | |
| Sf3b5 | uniprot | |
| Sfrs4 | uniprot | |
| Snrpb2 | uniprot | |
| Sf3a3 | uniprot | |
| Snrpa1 | uniprot | |
| Sf3a1 | uniprot | |
| Sf3a2 | uniprot | |
| Sf3b1 | uniprot | |
| Sf3b2 | ||
| Sf3b3 | ||
| Sf3b4 | ||
| Dhx38 | ||
| Cdc40 | uniprot | |
| Dnajc8 | uniprot | |
| Prpf8 | uniprot | |
| Phf5a | uniprot | |
| Prpf4 | uniprot | |
| Nhp2l1 | uniprot | |
| Prpf4 | uniprot | |
| Lsm2 | uniprot | |
| Nhp2l1 | uniprot | |
| Prpf8 | uniprot | |
| Cstf3 | uniprot | |
| AI462438 | ||
| Papola | uniprot | |
| 1500011J06Rik | ||
| Ddx1 | uniprot | |
| Hrmt1l1 | uniprot | |
| Hrmt1l2 | uniprot | |
| Pcbp2 | uniprot | |
| Dicer1 | uniprot | |
| Ddx20 | uniprot | |
| Dhx15 | uniprot | |
| Dhx8 | ||
| Prpf4b | uniprot | |
| Nxf1 | uniprot | |
| Dhx16 | ||
| Cugbp1 | uniprot | |
| Rnpc2 | uniprot | |
| Prpf18 | uniprot | |
| Brunol4 | ||
| Nono | uniprot | |
| Xrn2 | uniprot | |
| Spop | uniprot | |
| Smn1 | uniprot | |
| Cugbp2 | ||
| Ptbp2 | uniprot | |
| Prpf3 | uniprot | |
| Fnbp3 | uniprot | |
| Rbm17 | uniprot | |
| Lsm7 | uniprot | |
| 2610317D23Rik | ||
| Lsm11 | uniprot | |
| D11Ertd730e | ||
| 1500034e06rik | ||
| Sfrs11 | ||
| Sfpq | uniprot | |
| U2af1 | uniprot | |
| Rbms1 | uniprot | |
| Rbms2 | uniprot | |
| Rnu108 | ||
| Adam5 | ||
| Afg3l1 | uniprot | |
| Acin1 | uniprot | |
| Rnpep | uniprot | |
| MGI:1926224 | ||
| Abcb4 | uniprot | |
| Cnot4 | uniprot | |
| BC013481 | ||
| Dnd1 | uniprot | |
| Cstf2t | uniprot | |
| Cirbp | uniprot | |
| Cdk9 | uniprot | |
| Csad | uniprot | |
| Cyp4f18 | uniprot | |
| Cpeb1 | ||
| Cpeb3 | ||
| Cpeb4 | ||
| Cova1 | uniprot | |
| Tia1 | uniprot | |
| Dazap1 | uniprot | |
| Dazl | uniprot | |
| MGI:2387367 | ||
| D15Ertd119e | ||
| D5Ertd700e | ||
| D8Ertd233e | uniprot | |
| Elavl1 | uniprot | |
| Elavl2 | uniprot | |
| Elavl3 | uniprot | |
| Elavl4 | uniprot | |
| Eral1 | uniprot | |
| AI255183 | ||
| Eif3s4 | uniprot | |
| Eif3s9 | uniprot | |
| Eif4g2 | uniprot | |
| Ewsr1 | uniprot | |
| AA407033 | ||
| AA522010 | ||
| Pcbp3 | uniprot | |
| Pcbp4 | uniprot | |
| Exosc9 | uniprot | |
| Polr2g | uniprot | |
| Prkr | uniprot | |
| 2810055E05Rik | ||
| Pum1 | uniprot | |
| Pum2 | uniprot | |
| Qk | ||
| Rad21 | uniprot | |
| Rae1 | uniprot | |
| Rnasel | uniprot | |
| Rpl12 | uniprot | |
| Rpl19 | uniprot | |
| Rpl22 | uniprot | |
| Rpl26 | uniprot | |
| Rpl32 | uniprot | |
| Rpl37 | uniprot | |
| Rpl39 | uniprot | |
| Rpl7 | uniprot | |
| Rpl8 | uniprot | |
| Rpl9 | uniprot | |
| Rps11 | uniprot | |
| Rps13 | uniprot | |
| Rps14 | uniprot | |
| Rps20 | uniprot | |
| Rps23 | uniprot | |
| Rps24 | uniprot | |
| Rps27 | uniprot | |
| Rps28 | uniprot | |
| Rps29 | uniprot | |
| Rps4x | uniprot | |
| Rps6 | uniprot | |
| Rps7 | uniprot | |
| Exosc4 | uniprot | |
| Sca1 | uniprot | |
| Scye1 | uniprot | |
| Slbp | uniprot | |
| Snrp1c | uniprot | |
| Son | ||
| Srp14 | uniprot | |
| Srp19 | uniprot | |
| Srp9 | uniprot | |
| Ssa2 | uniprot | |
| Nhp2l1 | uniprot | |
| Stau1 | uniprot | |
| Tarbp2 | uniprot | |
| Tenr | ||
| Tert | uniprot | |
| Trim21 | uniprot | |
| Tsn | uniprot | |
| Wbp4 | uniprot | |
| Zbp1 | uniprot | |
| Zfp346 | uniprot | |
| Zfp385 | ||
| Auh | uniprot | |
| Eif4e2 | uniprot | |
| Srpk1 | uniprot | |
| Srpk2 | uniprot | |
| Ppm1g | uniprot | |
| Pskh1 | uniprot | |
| MGI:2661424 | ||
| SRrp40 | uniprot | |
| Rnps1 | uniprot | |
| Srp54 | uniprot | |
| Clk2 | uniprot | |
| Clk3 | uniprot | |
| Sfrs10 | uniprot | |
| Sfrs2 | uniprot | |
| Sfrs3 | uniprot | |
| Sfrs5 | uniprot | |
| Srrm1 | uniprot | |
| Sfrs6 | ||
| Sfrs7 | uniprot | |
| Sfrs9 | uniprot | |
| Prp17 | uniprot | |
| U4 snRNA | ||
| Rnu2 | ||
| Rnu1a1 | uniprot | |
| Rnu1a2 | ||
| Rnu1b1 | ||
| Rnu1b2 | ||
| Rnu6 | ||
| U5 snRNA | ||
| Hnrpr | ||
| Nhp2l1 | uniprot | |
| Tmed10 | uniprot | |
| 0610009D07Rik | ||
| Rnpepl1 | ||
| 1700012H05Rik | ||
| Rbm15b | uniprot | |
| 2610102M01Rik | ||
| AA589495 | ||
| AI194270 | ||
| Safb2 | uniprot | |
| AI255207 | ||
| AI255212 | ||
| AI255215 | ||
| AI255219 | ||
| AI255230 | ||
| D9Mgi24 | chemical | |
| AI255750 | ||
| AI255840 | ||
| AI255847 | ||
| AI256346 | ||
| AI256354 | ||
| AI314192 | ||
| AI447568 | ||
| Sfrs12 | uniprot | |
| AI462171 | ||
| AI467299 | ||
| AI503051 | ||
| AI504630 | ||
| Raly | uniprot | |
| Htf9c | uniprot | |
| Igf2bp1 | ||
| Igf2bp3 | ||
| Uhmk1 | uniprot | |
| Matr3 | uniprot | |
| Matr3-ps1 | ||
| Matr3-ps2 | ||
| Mki67ip | uniprot | |
| Spen | uniprot | |
| Msi1h | uniprot | |
| Msi2h | uniprot | |
| Myef2 | uniprot | |
| Syncrip | uniprot | |
| Nsap1l-pending | ||
| Zfml | uniprot | |
| Ncl | uniprot | |
| Pspc1 | chemical | |
| Ppil4 | uniprot | |
| Ppie | uniprot | |
| Ppargc1a | uniprot | |
| Rbm7 | uniprot | |
| 1500012C14Rik | ||
| 1600023H17Rik | ||
| 1700003D06Rik | ||
| 1700009P03Rik | chemical | |
| 1700025B16Rik | ||
| 1700047G05Rik | ||
| 1700095D18Rik | ||
| 1810035L17Rik | ||
| 1810036A22Rik | ||
| 1810036E18Rik | ||
| Rbm18 | uniprot | |
| 2010300K22Rik | ||
| 2010319N22Rik | ||
| 2210008M09Rik | ||
| Afg3l2 | uniprot | |
| 2310046H11Rik | ||
| Rbpms2 | chemical | |
| Rad52b | ||
| 2410013L13Rik | ||
| Wdr55 | uniprot | |
| Hnrpll | uniprot | |
| 2810036M01Rik | ||
| Rbmx2 | uniprot | |
| 2810411C16Rik | ||
| 2810441O16Rik | ||
| 2810442I21Rik | ||
| Rbm28 | uniprot | |
| 3000004N20Rik | ||
| Hnrpa0 | ||
| 3100004P22Rik | chemical | |
| 3110061K15Rik | ||
| 3200001K10Rik | ||
| 3830425H19Rik | ||
| 4632417O19Rik | ||
| Hnrpf | uniprot | |
| 4921506I22Rik | ||
| Nol8 | uniprot | |
| 4922503N01Rik | ||
| 4930422M05Rik | ||
| Lrrn6a | ||
| 4930506D01Rik | ||
| 9130414A06Rik | ||
| 9430070C08Rik | ||
| 9530027K23Rik | ||
| Tnrc6c | chemical | |
| B230118G17Rik | ||
| B230333C21Rik | ||
| B930007L02Rik | ||
| C230097K14Rik | ||
| Rbed1 | ||
| C330027G06Rik | ||
| C430048L16Rik | ||
| D230005D02Rik | ||
| D330023I21Rik | ||
| D830027H13Rik | ||
| G430095G15Rik | ||
| Thoc4 | uniprot | |
| Refbp2 | uniprot | |
| Rbm8a | uniprot | |
| Rbm10 | uniprot | |
| Rbm11 | ||
| Rbm12 | uniprot | |
| Tiaf1 | uniprot | |
| Tial1 | uniprot | |
| Traf6 | uniprot | |
| Tlr5 | uniprot | |
| Tnrc4 | ||
| Rnu11 | ||
| Rnu1a1 | uniprot | |
| Rnu1b1 | ||
| Rnu1b2 | ||
| Rnu1b6 | ||
| U2af1-rs1 | uniprot | |
| U2af1-rs2 | uniprot | |
| Rnu2 | ||
| V1rc17 | ||
| Wdr9 | uniprot | |
| Wbscr1 | uniprot | |
| A130095G20Rik | ||
| AI043106 | ||
| Rbm3 | uniprot | |
| Rnaset2 | uniprot | |
| Rpl38 | uniprot | |
| 1110017C15Rik | ||
| 4930534J06Rik | ||
| Ppp1r8 | uniprot | |
| Papolg | uniprot | |
| 9630048M01Rik | ||
| Aco1 | uniprot | |
| Adar | uniprot | |
| Adarb2 | uniprot | |
| Adat1 | ||
| Akap1 | uniprot | |
| Bard1 | uniprot | |
| Bat1a | uniprot | |
| Bicc1 | chemical | |
| Brca1 | uniprot | |
| Ciz1 | chemical | |
| Zfp622 | uniprot | |
| D19Bwg1357e | ||
| D1Pas1 | uniprot | |
| D1Pas1-rs1 | uniprot | |
| Imp4 | uniprot | |
| D3Jfr1 | uniprot | |
| Exosc5 | uniprot | |
| Ddx19a | uniprot | |
| Ddx21 | uniprot | |
| Ddx24 | uniprot | |
| Ddx25 | uniprot | |
| Ddx39 | uniprot | |
| Ddx3x | uniprot | |
| Ddx4 | uniprot | |
| Ddx41 | uniprot | |
| AI642080 | ||
| AI843301 | ||
| AI844780 | ||
| AL022933 | ||
| D12Mgi43 | chemical | |
| D12Mgi40 | chemical | |
| AU023006 | ||
| AU045931 | ||
| AW049977 | ||
| AW107884 | ||
| AW260507 | ||
| AW553050 | ||
| BB131279 | ||
| C79783 | ||
| C80672 | ||
| C85084 | ||
| Ggcx | uniprot | |
| Grsf1 | uniprot | |
| Hdp | ||
| Hnrpdl | ||
| H2-Bf | uniprot | |
| Ppargc1b | uniprot | |
| Pabpc1 | uniprot | |
| Pabpc2 | chemical | |
| Pabpc4 | chemical | |
| Pabpc5 | chemical | |
| Poldip3 | uniprot | |
| Pcolce | uniprot | |
| Col4a3 | ||
| Ppp1r14b | uniprot | |
| G3bp2-pending | ||
| MGI:1351465 | ||
| Rdbp | uniprot | |
| 0610009J05Rik | ||
| 0610033I05Rik | ||
| 0710005M24Rik | ||
| Ilkap | ||
| 1110034O07Rik | ||
| 1110037F02Rik | ||
| Rbm19 | uniprot | |
| 1200009B18Rik | ||
| 1300006N24Rik | ||
| 2410104I19Rik | ||
| 2410112D09Rik | ||
| 2600011C06Rik | ||
| Rbm13 | uniprot | |
| 2600016C11Rik | ||
| 2600016F06Rik | ||
| Htatsf1 | uniprot | |
| 2610015J01Rik | ||
| Sfrs11 | ||
| 2610020N02Rik | ||
| 2610023M21Rik | ||
| 2610024A01Rik | ||
| 2610101N10Rik | ||
| Bclaf1 | uniprot | |
| 2610209F03Rik | ||
| Hnrpa3 | uniprot | |
| Rbm17 | uniprot | |
| 2700028P07Rik | chemical | |
| Rbm21 | uniprot | |
| 2700077B20Rik | ||
| 2700088M22Rik | ||
| 4930554P13Rik | chemical | |
| 4930562C03Rik | ||
| 4930565A21Rik | ||
| Boll | uniprot | |
| 4932422E22Rik | ||
| 4932422M17Rik | ||
| 4932702K14Rik | ||
| Rbm31y | ||
| 5031411E02Rik | ||
| 5330419I02Rik | ||
| 5730453I16Rik | ||
| Tdrd7 | uniprot | |
| 5730555F13Rik | ||
| 5730557B15Rik | ||
| 5730557H03Rik | ||
| 6330548G22Rik | ||
| Brunol6 | ||
| Rbms3 | chemical | |
| 6720478K01Rik | ||
| 8030431D03Rik | ||
| Rbm22 | uniprot | |
| Rbm14 | uniprot | |
| Rbm16 | ||
| Rbm4 | uniprot | |
| Rbm6 | ||
| Rbm9 | ||
| Rbmx | uniprot | |
| Rbmxrt | uniprot | |
| Rbmy1a1 | ||
| Rbpms | uniprot | |
| Rnu12 | ||
| Rnpc1 | uniprot | |
| Rod1 | uniprot | |
| Sfrs10 | uniprot | |
| Ssb | uniprot | |
| Sbno1 | chemical | |
| Slc25a4 | uniprot | |
| Slc6a8 | uniprot | |
| Sart3 | uniprot | |
| Synj2 | uniprot | |
| Taf15 | ||
| Tardbp | uniprot | |
| 1110033J19Rik | ||
| 1190002L16Rik | ||
| 1190005F20Rik | ||
| Eif4e3 | ||
| Eif4g3 | uniprot | |
| Lsm8 | uniprot | |
| 2010003O18Rik | ||
| Rpl11 | uniprot | |
| Exosc8 | uniprot | |
| 2400002F11Rik | ||
| Rnaseh2a | uniprot | |
| 2410003C20Rik | ||
| Exosc7 | uniprot | |
| Srp68 | uniprot | |
| 2610027L16Rik | ||
| Zmat2 | uniprot | |
| Rpp14 | uniprot | |
| Ttc14 | uniprot | |
| Secisbp2 | uniprot | |
| Lsm1 | uniprot | |
| 2810028N01Rik | ||
| Ddx19b | ||
| Rps9 | uniprot | |
| Rnmtl1 | ||
| 4930429A22Rik | ||
| 4930517K11Rik | ||
| Ddx48 | uniprot | |
| Ddx5 | uniprot | |
| Ddx56 | uniprot | |
| Ddx6 | uniprot | |
| Dkc1 | uniprot | |
| Eif4a2 | uniprot | |
| Eif4e | uniprot | |
| Fbl | uniprot | |
| Fmr1 | uniprot | |
| Fxr1h | uniprot | |
| Fxr2h | uniprot | |
| Ilf3 | uniprot | |
| Lgtn | uniprot | |
| Lsm4 | uniprot | |
| Mbnl1 | uniprot | |
| Mrpl11 | uniprot | |
| Mrpl23 | uniprot | |
| Mrps28 | uniprot | |
| Npm1 | uniprot | |
| Nufip1 | uniprot | |
| Nxf7 | ||
| Oas1a | uniprot | |
| Oas1b | uniprot | |
| Oas1g | ||
| Oas2 | ||
| Oas3 | ||
| Oasl2 | uniprot | |
| Papolb | uniprot | |
| Park7 | uniprot | |
| Pcbp1 | uniprot | |
| 5 G cap | ||
| 3 | ||
| 5 | ||
| 3 | ||
| 5 | ||
| 3 | ||
| 5 | ||
| Polr2a | uniprot | |
| Spt5 | uniprot | |
| Rnmt (methyltransferase) | ||
| GMP | hmdbid:HMDB01397 | uniprot |
| mRNA Capping | ||
| Processing of Intron-Containing Pre-mRNA | ||
| iPo | ||
| Cap Binding | ||
| Methylation of mRNA | ||
| heterogeneous nuclear ribonucleoproteins | ||
| Formation of pre-mRNPs | ||
| Internal methylation of mRNA | ||
| mRNA splicing (major pathway) | ||
| pre-mRNA | ||
| Primary RNA transcript | ||
| hnRNPs | ||
| Formation of the Spliceosomal E complex | ||
| snRNP Sm core complex | ||
| U1 snRNP | ||
| 3 | ||
| exon 1 | ||
| exon 2 | ||
| intron | ||
| GU | ||
| A | ||
| YYYY | ||
| AG | ||
| 5 | ||
| SR-binding sites | ||
| SR-binding sites | ||
| U1 snRNP | ||
| U2AF | ||
| 65 | ||
| 35 | ||
| RNA helicase A | ||
| U2AF | ||
| Serine/Argenine Rich Proteins(SR) | ||
| mRNA capping | ||
| Internal methylation of mRNA | ||
| Formation of pre-mRNPs | ||
| SR-proteins | ||
| Regulation of | ||
| Alternative Splicing | ||
| Additional Factors | ||
| Regulators | ||
| splicing factor SF3A | ||
| splicing factor SF3B | ||
| U2 snRNPs | ||
| SF3b14b | uniprot | |
| SR-proteins | ||
| Additional Factors | ||
| RNA helicase | ||
| U2 snRNP | ||
| snRNP Sm core complex | ||
| Formation of the Spliceosomal A complex | ||
| Formation of the Spliceosomal E complex | ||
| Formation of the Spliceosomal A complex | ||
| U2 snRNP | ||
| 3 | ||
| A | ||
| YYYY | ||
| AG | ||
| 5 | ||
| exon 1 | ||
| exon 2 | ||
| U4/U6 | ||
| U5 | ||
| Formation of the Spliceosomal B complex | ||
| U4 snRNP | ||
| U6 snRNP | ||
| U5 snRNP | ||
| snRNP Sm core complex | ||
| U4:U5:U6 tri-snRNP complex | ||
| YYYY | ||
| AG | ||
| 5 | ||
| exon 1 | ||
| exon 2 | ||
| A | ||
| 3 | ||
| U5 | ||
| Note: New participating members shown at each step | ||
| UG | ||
| U6 | ||
| U2 | ||
| U4 | ||
| U1 | ||
| Formation of the Spliceosomal C complex | ||
| Poly(A)-binding protein II | uniprot | |
| CF II | ||
| Poly(A) polymerase alpha | uniprot | |
| CF I | chemical | |
| YYYY | ||
| AG | ||
| 5 | ||
| exon 2 | ||
| A | ||
| 3 | ||
| UG | ||
| exon 1 | ||
| YYYY | ||
| AG | ||
| 5 | ||
| A | ||
| 3 | ||
| exon 1 | ||
| exon 2 | ||
| YYYY | ||
| AG | ||
| A | ||
| 5 | ||
| exon 2 | ||
| CstF | ||
| CFI | enzyme | uniprot |
| CF II | ||
| Poly(A)pb II | ||
| Poly(A) pol | ||
| 5 | ||
| 3 | ||
| AAAAAAA | ||
| Pi | ||
| P- | ||
| degraded | ||
| SR protein kinases | ||
| Additional SR proteins | ||
| Putative Alternative Splicing | ||
| Accessory Proteins | ||
| mRNA splice site selection | ||
| hnRNP regulators | ||
| RNAi pathway | ||
| 3 | ||
| exon 1 | ||
| Additional Factors | ||
| Formation of the Spliceosomal B complex | ||
| Formation of the active Spliceosomal C complex | ||
| Lariat Formation and 5’-Splice Site Cleavage | ||
| Cleavage at the 3’-Splice-Site and Exon Ligation | ||
| (1) | ||
| (2) | ||
| (2a) | ||
| (2b) | ||
| (2c) | ||
| (3) | ||
| mRNA 3’-end processing | ||
| Cleavage of mRNA at the 3’-end | ||
| mRNA polyadenylation | ||
| CPSF | ||
| CstF | ||
| right click on blue text for detailed information | ||
| 5 | ||
| 3 | ||
| AAUAAA | ||
| CA | ||
| ATP | hmdbid:HMDB00538 | |
| CPSF | ||
| splicesome associated helicases | ||
| Misc. | ||
| Rngtt (capping enzyme) | ||
| InterPro Domain Containing: | ||
| RNA-binding region RNP-1 (RNA recognition motif) | ||
| Gene Ontology: RNA Binding | ||
| SR-kinases | ||
| Kinases Phosphorylating RS domains? | ||
| P | ||
| SR-phosphatases | ||
| SR-proteins | ||
| SR protein phosphatases | ||
| SR-repressor proteins |
| RBPSUHL | uniprot | |
| PTCRA | ||
| CIR | hmdbid:HMDB00904 | uniprot |
| HDAC2 | uniprot | |
| HDAC1 | uniprot | |
| CTBP1 | uniprot | |
| CTBP2 | uniprot | |
| LOC330129 | ||
| CREBBP | uniprot | |
| GCN5L2 | uniprot | |
| PCAF | uniprot | |
| DLL1 | uniprot | |
| DLL3 | uniprot | |
| DLL4 | uniprot | |
| JAG1 | uniprot | |
| JAG2 | uniprot | |
| LFNG | uniprot | |
| MFNG | uniprot | |
| RFNG | uniprot | |
| NOTCH1 | uniprot | |
| NOTCH2 | uniprot | |
| NOTCH3 | uniprot | |
| NOTCH4 | uniprot | |
| ADAM17 | uniprot | |
| APH1A | uniprot | |
| APH1B | uniprot | |
| TNF | uniprot | |
| PSEN1 | uniprot | |
| PSEN2 | uniprot | |
| NCSTN | uniprot | |
| DVL1 | uniprot | |
| DVL2 | uniprot | |
| DVL3 | uniprot | |
| NUMB | uniprot | |
| NUMBL | uniprot | |
| DTX1 | uniprot | |
| DTX2 | uniprot | |
| DTX3 | uniprot | |
| DTX4 | ||
| DTX31 | ||
| RBP-J | uniprot | |
| SKIP | uniprot | |
| MAML3 | uniprot | |
| MAML1 | uniprot | |
| NCOR2 | uniprot | |
| HES1 | uniprot | |
| HES5 | ||
| NICD | ||
| co-repressor complex | ||
| DNA | CHEBI:16991 | |
| Notch Intracellular Domain | ||
| MAPK signaling pathway | ||
| gene expression | ||
| S2 | ||
| S3 | ||
| Ras/Map |
| Rxrg | uniprot |
| Thra | uniprot |
| Rarb | uniprot |
| Ppara | uniprot |
| Ppard | uniprot |
| Pparg | uniprot |
| Nr1d2 | uniprot |
| Nr0b1 | uniprot |
| Rora | uniprot |
| Rorb | uniprot |
| Rorc | uniprot |
| Nr1h2 | uniprot |
| Nr1h3 | uniprot |
| Vdr | uniprot |
| Nr1i2 | uniprot |
| Nr1i3 | uniprot |
| Hnf4a | uniprot |
| Nr2e1 | uniprot |
| Nr2c2 | uniprot |
| Nr2f1 | uniprot |
| Nr2f2 | uniprot |
| Nr2f6 | uniprot |
| Esr1 | uniprot |
| Esr2 | uniprot |
| Esrra | uniprot |
| Esrrb | uniprot |
| Nr3c1 | uniprot |
| Pgr | uniprot |
| Ar | |
| Nr4a1 | uniprot |
| Nr4a2 | uniprot |
| Nr5a1 | uniprot |
| Nr5a2 | uniprot |
| Rxrb | uniprot |
| Rara | uniprot |
| Rxra | uniprot |
| Rarg | uniprot |
| Thrb | uniprot |
| Thyroid Receptor | |
| Peroxisome Proliferator | |
| Nuclear Receptor ROR | |
| Oxysterols Receptor | |
| Vitamin D3 Receptor | uniprot |
| Hepatocyte Nuclear | |
| Orphan Nuclear | |
| Nuclear receptor TLX | uniprot |
| Coup Transcription | |
| Estrogen Receptor | uniprot |
| Steroid Hormone Receptor | |
| Glucocorticoid Receptor | uniprot |
| Progesterone Receptor | uniprot |
| Androgen Receptor | uniprot |
| NR5 SUPERFAMILY | |
| Steroidogenic Receptor | |
| Orphan Receptor | |
| NR0 SUPERFAMILY | |
| NR1 SUPERFAMILY | |
| NR2 SUPERFAMILY | |
| NR3 SUPERFAMILY | |
| NR4 SUPERFAMILY | |
| Orphan Receptor | |
| Activated Receptor | |
| Orphan Nuclear | |
| Receptor | |
| Retinoic Acid Receptor (RAR) | |
| Retinoic Acid | hmdbid:HMDB06219 |
| Factor | |
| Factor | |
| Receptor (RXR) | |
| Receptor |
| Cyp7a1 | uniprot | |
| Cyp7a1 | uniprot | |
| Cyp7a1 | uniprot | |
| Cyp4a11 | uniprot | |
| Pparg | uniprot | |
| Ppara | uniprot | |
| Ppard | uniprot | |
| Abcd3 | uniprot | |
| Abcd2 | uniprot | |
| Abca1 | uniprot | |
| Abca1 | uniprot | |
| Abca1 | uniprot | |
| Abcb4 | uniprot | |
| Abcb11 | uniprot | |
| Abcb1a | uniprot | |
| Abcb1b | uniprot | |
| ABCC2 | uniprot | |
| Abcc3 | uniprot | |
| Abcg1 | uniprot | |
| Abcg5 | uniprot | |
| abcg6 | ||
| Nr1h4 | uniprot | |
| Nr1h3 | uniprot | |
| Cyp8b1 | uniprot | |
| Nr1i2 | uniprot | |
| Nr1i3 | uniprot | |
| Cyp4b1 | uniprot | |
| Rara | uniprot | |
| Rarg | uniprot | |
| Cyp3a13 | uniprot | |
| Vdr | uniprot | |
| Cyp3a13 | uniprot | |
| Cyp26a1 | uniprot | |
| Rarb | uniprot | |
| Cyp2e1 | uniprot | |
| Cyp2c38 | uniprot | |
| Cyp2c38 | uniprot | |
| Cyp2b6 | ||
| Cyp2b6 | ||
| Cyp1a2 | uniprot | |
| Cyp24a1 | uniprot | |
| Cyp2c38 | uniprot | |
| Cyp3a13 | uniprot | |
| Cyp27b1 | uniprot | |
| Right click for comments | ||
| Acetyl CoA | hmdbid:HMDB01206 | uniprot |
| Isoprenoids | CHEBI:24913 | |
| Lanosterol | hmdbid:HMDB01251 | |
| 7-DehydroCholesterol | hmdbid:HMDB00032 | |
| Cholesterol | hmdbid:HMDB00067 | |
| Oxysterol | chemical | |
| Bile Acids | CHEBI:3098 | |
| 1,25-Dihydroxy-Vitamins D3 | ||
| Fatty Acids | CHEBI:35366 | |
| DIET | ||
| Xenobiotics | CHEBI:35703 | |
| DIET | ||
| Retinoic Ac | ||
| Steroids | CHEBI:35341 | |
| Gene expression |
| Adora1 | uniprot |
| Adora2a | uniprot |
| Adora2b | uniprot |
| Adora3 | uniprot |
| P2ry1 | uniprot |
| P2ry1 | uniprot |
| P2ry2 | uniprot |
| P2ry4 | uniprot |
| P2y5 | uniprot |
| P2ry6 | uniprot |
| Ltb4r1 | uniprot |
| P2Y3 | uniprot |
| P2Y9 | uniprot |
| Adenosine | hmdbid:HMDB00050 |
| Adenine | hmdbid:HMDB00034 |
| Gi/Go Pathway | |
| Gs Pathway | |
| Gq/G11 Pathway |
| Adsl | uniprot | |
| Mthfd2 | uniprot | |
| Dhfr | uniprot | |
| Pura | uniprot | |
| Prps1 | uniprot | |
| Prps2 | uniprot | |
| Hprt1 | uniprot | |
| Oaz1 | uniprot | |
| Srm | uniprot | |
| Sat1 | uniprot | |
| Rrm1 | uniprot | |
| Pold1 | uniprot | |
| Polg | uniprot | |
| Pola1 | uniprot | |
| Polb | uniprot | |
| Nme2 | uniprot | |
| Impdh1 | uniprot | |
| Ribose | hmdbid:HMDB00283 | |
| PRPP | hmdbid:HMDB00280 | uniprot |
| SAICAR | hmdbid:HMDB00797 | |
| AICAR | hmdbid:HMDB03192 | |
| IMP | hmdbid:HMDB00175 | uniprot |
| DNA | CHEBI:16991 | |
| DNA Synthesis | ||
| dNTPs | ||
| dNTPs | ||
| GMP | hmdbid:HMDB01397 | uniprot |
| dNTPs | ||
| Xanthine | hmdbid:HMDB00292 | |
| GMP | hmdbid:HMDB01397 | uniprot |
| Guanine | hmdbid:HMDB00132 | |
| Uric Acid | hmdbid:HMDB00289 | |
| Adenylosuccinate | hmdbid:HMDB00536 | |
| AMP | hmdbid:HMDB00045 | uniprot |
| Hypoxanthine | hmdbid:HMDB00157 | |
| Spermine | hmdbid:HMDB01256 | |
| Adenine | hmdbid:HMDB00034 | |
| Spermidine | hmdbid:HMDB01257 | |
| Putrescine | hmdbid:HMDB01414 | |
| Ornithine | hmdbid:HMDB03374 | |
| Polyamine | chemical | |
| Synthesis | ||
| Monophasphate | chemical |
| Gdf9 | uniprot |
| Gja4 | uniprot |
| Gja4 | uniprot |
| Pgr | uniprot |
| Esr2 | uniprot |
| Nr5a1 | uniprot |
| Tbp | uniprot |
| Ncor1 | uniprot |
| Egr1 | uniprot |
| Smpd1 | uniprot |
| Zp3 | uniprot |
| Zp2 | uniprot |
| Figla | uniprot |
| Mlh1 | uniprot |
| Bmpr1b | uniprot |
| Cyp19a1 | uniprot |
| Ptger2 | uniprot |
| Lhcgr | uniprot |
| Fshr | uniprot |
| Dazl | uniprot |
| Vdr | uniprot |
| Nrip1 | uniprot |
| Smpd1 | uniprot |
| Inha | uniprot |
| Dmc1h | uniprot |
| Smad3 | uniprot |
| Atm | uniprot |
| Cebpb | uniprot |
| Cdk4 | uniprot |
| Cdkn1b | uniprot |
| Ccnd2 | uniprot |
| Msh5 | uniprot |
| Prlr | uniprot |
| Granulosa Cell | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Oocyte | |
| Nucleus | CHEBI:33252 |
| Ooplasm |
| Maoa | uniprot |
| Nfix | uniprot |
| Nrf2 | uniprot |
| Nfkb1 | uniprot |
| Sp1 | uniprot |
| Hmox1 | uniprot |
| Gpx1 | uniprot |
| Gpx3 | uniprot |
| Nqo1 | uniprot |
| Ugt1a@ | |
| Cat | |
| Txn2 | uniprot |
| Txnrd1 | uniprot |
| Txnrd2 | uniprot |
| Gclc | uniprot |
| Gsr | uniprot |
| Mt1 | uniprot |
| Gstt2 | uniprot |
| Mgst1 | uniprot |
| Cyp1a1 | uniprot |
| Xdh | uniprot |
| Cyba | uniprot |
| Fos | uniprot |
| Junb | uniprot |
| Sod2 | uniprot |
| Sod1 | uniprot |
| Sod3 | uniprot |
| Mapk14 | uniprot |
| Mapk10 | uniprot |
| antioxidant genes | |
| Induction of | |
| Inhibition of oxidases | |
| TF inhibition | |
| repression | |
| TF activation | |
| Immediate-early | |
| gene induction | |
| Reactive Oxygen Species | CHEBI:26523 |
| Adaptive response | |
| Repression of ROS- | |
| producing systems | |
| Activation | chemical |
| Stress-regulated MAP kinase |
| Mapk14 | uniprot | |
| Mapk14 | uniprot | |
| Map2k6 | uniprot | |
| Map3k9 | ||
| Map3k7 | uniprot | |
| Map3k5 | uniprot | |
| Mknk1 | uniprot | |
| prak | ||
| Hspb1 | uniprot | |
| Mapkapk2 | uniprot | |
| Mapkapk2 | uniprot | |
| Atf2 | uniprot | |
| Rps6ka5 | uniprot | |
| Mef2d | uniprot | |
| Ddit3 | uniprot | |
| Elk1 | uniprot | |
| Stat1 | uniprot | |
| Max | ||
| Myc | uniprot | |
| Hmgn1 | uniprot | |
| Creb1 | uniprot | |
| Pla2g4a | uniprot | |
| mkk4 | ||
| Map3k1 | uniprot | |
| Rac1 | uniprot | |
| Cdc42 | uniprot | |
| Ras | uniprot | |
| Tgfbr1 | uniprot | |
| Tgfb2 | uniprot | |
| Tradd | chemical | |
| traff2 | ||
| Daxx | uniprot | |
| ripk1 | uniprot | |
| Shc1 | uniprot | |
| Grb2 | uniprot | |
| ras-gef | ||
| Apoptosis | ||
| Translation | ||
| ? | ||
| ? | ||
| ? | ||
| Stress: Osmotic shock | ||
| g-radiation, Anisomycin | ||
| Right click for comments | ||
| FASL, Inflammatory | ||
| Cytokines, UV, etc. | ||
| Growth Factors, UV | ||
| Trophic Factors, etc. | ||
| DNA transcription | ||
| Cytokines Production, | ||
| Apoptosis, etc. | ||
| ? | ||
| ? |
| G6pd2 | uniprot |
| G6pdx | uniprot |
| Pgd | uniprot |
| Pgls | uniprot |
| Rpe | uniprot |
| Tkt | uniprot |
| Taldo1 | uniprot |
| Rpia | uniprot |
| Tkt | uniprot |
| Glucose-6-Phosphate | hmdbid:HMDB01401 |
| 6-Phosphoglucono-delta-lactone | hmdbid:HMDB01127 |
| 6-Phosphogluconate | hmdbid:HMDB01316 |
| Ribulose-5-Phosphate | hmdbid:HMDB00618 |
| Ribose-5-Phosphate | hmdbid:HMDB01548 |
| (Hexose Monophosphosphate Shunt | |
| or Phosphogluconate Pathway) | |
| Fructose-6-Phosphate + Erythose-4-Phosphate | |
| Fructose-6-Phosphate | hmdbid:HMDB00124 |
| Sedoheptulose-7-Phosphate | hmdbid:HMDB01068 |
| + | |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 |
| + | |
| Glycolysis/Gluconeogenesis | |
| Xylulose-5-Phosphate | hmdbid:HMDB00868 |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 |
| Nucleotide | chemical |
| Biosynthesis |
| Ntsr2 | uniprot | |
| Oprk1 | uniprot | |
| Agtr1 | uniprot | |
| Agtr1b | uniprot | |
| Agtr2 | uniprot | |
| Bdkrb2 | uniprot | |
| Bdkrb1 | uniprot | |
| Nmbr | uniprot | |
| Grpr | uniprot | |
| Brs3 | uniprot | |
| Ccr1 | uniprot | |
| Ccr2 | uniprot | |
| Ccr3 | uniprot | |
| Ccr4 | uniprot | |
| Ccr5 | uniprot | |
| Ccr7 | uniprot | |
| Ccr8 | uniprot | |
| Ccr9 | uniprot | |
| Gpr2 | uniprot | |
| Ccr1l1 | uniprot | |
| Cxcr6 | ||
| Blr1 | uniprot | |
| Cxcr4 | uniprot | |
| Cxcr3 | uniprot | |
| C3ar1 | uniprot | |
| C5r1 | uniprot | |
| Cx3cr1 | uniprot | |
| Il8rb | uniprot | |
| Fpr1 | uniprot | |
| Fprl1 | uniprot | |
| Cckar | uniprot | |
| Cckbr | uniprot | |
| Ednra | uniprot | |
| Ednrb | uniprot | |
| Galr1 | uniprot | |
| Galr2 | uniprot | |
| Galr3 | uniprot | |
| Fshr | uniprot | |
| Lhcgr | uniprot | |
| Tshr | uniprot | |
| Mc2r | uniprot | |
| Mc1r | uniprot | |
| Mc3r | uniprot | |
| Mc4r | uniprot | |
| Mc5r | uniprot | |
| Npy1r | uniprot | |
| Npy2r | uniprot | |
| Ppyr1 | uniprot | |
| Npy5r | uniprot | |
| Npy6r | uniprot | |
| Ntsr1 | uniprot | |
| Oprd1 | uniprot | |
| Oprm1 | uniprot | |
| Oprl1 | uniprot | |
| Gnrhr | uniprot | |
| Trhr | uniprot | |
| Ghsr | uniprot | |
| Tacr1 | uniprot | |
| Tacr2 | uniprot | |
| Tacr3 | uniprot | |
| Sstr1 | uniprot | |
| Sstr2 | uniprot | |
| Sstr3 | uniprot | |
| Sstr4 | uniprot | |
| Sstr5 | uniprot | |
| Avpr1b | uniprot | |
| Avpr2 | uniprot | |
| Oxtr | uniprot | |
| Ccr6 | uniprot | |
| Avpr1a | uniprot | |
| Releasing Hormone | ||
| Receptors | ||
| Opioid Receptors | ||
| Neuropeptide Y Receptors | uniprot | |
| Neurotensin Receptors | ||
| Chemokine Receptors | ||
| Chemotactic Receptors | ||
| Angiotensin Receptors | ||
| Bombesin Receptors | ||
| Endothelin Receptors | ||
| Vasopressin and | ||
| Oxytocin | hmdbid:HMDB02865 | uniprot |
| Galanin Receptors | ||
| Receptors | ||
| Glycoprotein Hormone | ||
| Receptors | ||
| Cholecystokinin/ | ||
| Bradykinin Receptors | ||
| Somatostatin Receptors | ||
| Tachykinin Receptors | ||
| Gq Coupled | ||
| Gi Coupled | ||
| Gs Coupled | ||
| Gastrin Receptors | ||
| Melanocortins |
| Ptgs1 | uniprot | |
| Ptgs2 | uniprot | |
| Anxa3 | uniprot | |
| Anxa2 | uniprot | |
| Anxa1 | uniprot | |
| Anxa6 | uniprot | |
| Anxa4 | uniprot | |
| Scgb1a1 | uniprot | |
| Anxa5 | uniprot | |
| Anxa8 | uniprot | |
| Hsd11b1 | uniprot | |
| Ednrb | uniprot | |
| Edn1 | uniprot | |
| Hpgd | uniprot | |
| Ednra | uniprot | |
| Hsd11b2 | uniprot | |
| Cyp11a1 | uniprot | |
| Pla2g4a | uniprot | |
| S100a10 | uniprot | |
| Ptgis | uniprot | |
| Ptgds | uniprot | |
| Tbxas1 | uniprot | |
| Ptgdr | uniprot | |
| Ptger1 | uniprot | |
| Ptger2 | uniprot | |
| Ptger3 | uniprot | |
| Ptger4 | uniprot | |
| Ptgfr | uniprot | |
| Ptgir | uniprot | |
| Tnfrsf1a | uniprot | |
| Tnf | uniprot | |
| PGF2 | uniprot | |
| PGI2 | hmdbid:HMDB01335 | uniprot |
| Ca | ||
| 2+ | ||
| Prostaglandin H2 | hmdbid:HMDB01381 | |
| TXA2 | hmdbid:HMDB01452 | |
| Cortisol | hmdbid:HMDB00063 | |
| PGE2 | hmdbid:HMDB01220 | |
| Cell Membrane | ||
| Phospholipids | CHEBI:16247 | |
| Inactive Metabolites | ||
| Cytoplasm | ||
| PG Synthases | ||
| Cortisone | hmdbid:HMDB02802 | |
| Cortisol | hmdbid:HMDB00063 | |
| Arachidonic Acid | hmdbid:HMDB01043 | |
| Progesterone | hmdbid:HMDB01830 | |
| Annexins | chemical | |
| Ca | ||
| 2+ | ||
| PG Receptors | ||
| Contraction |
| Ubc | uniprot | |
| Hist1h2ac | uniprot | |
| H2afx | uniprot | |
| H2afz | uniprot | |
| Ube1x | uniprot | |
| Ube1l | ||
| Psmc1 | uniprot | |
| Nedd4 | uniprot | |
| Psmc6 | uniprot | |
| Psmd1 | uniprot | |
| Psmd2 | uniprot | |
| Psmd3 | uniprot | |
| Psmd5 | uniprot | |
| Psmd4 | uniprot | |
| Psmc5 | uniprot | |
| Psmc2 | uniprot | |
| Psmc3 | uniprot | |
| Psmc4 | uniprot | |
| Psma1 | uniprot | |
| Psma2 | uniprot | |
| Psmb1 | uniprot | |
| Psma3 | uniprot | |
| Psma4 | uniprot | |
| Psmb3 | uniprot | |
| Psmb6 | uniprot | |
| Psmb7 | uniprot | |
| Psmb5 | uniprot | |
| Psmb4 | uniprot | |
| Psme1 | uniprot | |
| Psme2 | uniprot | |
| Ifng | uniprot | |
| Psmb9 | uniprot | |
| Psmb10 | uniprot | |
| Psmb8 | uniprot | |
| Psme3 | uniprot | |
| Psmd7 | uniprot | |
| Psmd6 | uniprot | |
| Psmd8 | uniprot | |
| Psmd9 | uniprot | |
| Psmd10 | uniprot | |
| Psmd11 | uniprot | |
| Psmd12 | uniprot | |
| Psmd13 | uniprot | |
| Psmc5 | uniprot | |
| Psma6 | uniprot | |
| Psma7 | uniprot | |
| Psma5 | uniprot | |
| Psmb2 | uniprot | |
| Rpn2 | uniprot | |
| Rpn1 | uniprot | |
| Ube2b | uniprot | |
| Ube2d2 | uniprot | |
| Ube2a | uniprot | |
| Ube2g2 | uniprot | |
| Ube2e1 | uniprot | |
| Ube2l3 | uniprot | |
| Ube2g1 | uniprot | |
| Ube2h | uniprot | |
| Ube2n | uniprot | |
| Ube2m | uniprot | |
| Hip2 | uniprot | |
| Ube2s | uniprot | |
| Ube2e3 | uniprot | |
| Ube2r2 | ||
| Ube2i | uniprot | |
| Psmd14 | uniprot | |
| Trim17 | uniprot | |
| Hist1h2ah | uniprot | |
| Hist2h2ac | uniprot | |
| Hist1h2ak | uniprot | |
| Hist1h2ab | uniprot | |
| Hist1h2ai | uniprot | |
| Hist1h2af | uniprot | |
| Hist1h2ae | uniprot | |
| Hist2h2ab | uniprot | |
| Hist1h2ag | uniprot | |
| Hist1h2ao | uniprot | |
| Hist1h2ad | uniprot | |
| Hist2h2aa2 | uniprot | |
| Hist1h2an | uniprot | |
| Hist3h2a | uniprot | |
| Hist2h2aa1 | uniprot | |
| ATP | hmdbid:HMDB00538 | |
| AMP Ubiquitin/E1 Complex | ||
| Ubiquitin/E2 Complex | ||
| E3/Protein | ||
| Proteins to be Degraded | ||
| Ubiquitin/Protein | ||
| Proteasome 26 S | ||
| (PA700) (ATP dependent) | ||
| p45 ATPase Subunit | ||
| Unfolds and Degrades | ||
| Intact Proteins | ||
| Proteasome 20S | ||
| Catalytic Core (p45) | ||
| Activators of | ||
| Degrades only Peptides | ||
| Presentation by MHC class 1 | ||
| Oxidatively Damaged | ||
| Cytosolic Proteins | ||
| 20S Complex | ||
| Lid subunits | ||
| Alpha subunits | ||
| Beta subunits | ||
| Histones | chemical |
| Ins1 | uniprot |
| Egfr | uniprot |
| Itga1 | uniprot |
| F2r | uniprot |
| F2 | |
| Fn1 | uniprot |
| Gna12 | uniprot |
| Sos1 | uniprot |
| Gna13 | uniprot |
| Arhgef6 | uniprot |
| Csk | uniprot |
| Vav1 | uniprot |
| Bcar1 | uniprot |
| Crk | uniprot |
| Ptk2 | uniprot |
| Mos | uniprot |
| Map2k1 | uniprot |
| Mapk1 | uniprot |
| Chrm1 | uniprot |
| Gng12 | uniprot |
| Fgd1 | uniprot |
| Cdc42 | uniprot |
| Iqgap1 | uniprot |
| Arhgef1 | uniprot |
| Diap3 | uniprot |
| Baiap2 | uniprot |
| Enah | uniprot |
| Was | |
| Arpc5 | uniprot |
| Actb | uniprot |
| Rhoa | uniprot |
| Rock1 | uniprot |
| Grlf1 | uniprot |
| Rac1p2 | chemical |
| Rac1 | uniprot |
| Rac4 | chemical |
| Rac3 | uniprot |
| Rac2 | uniprot |
| Cd14 | uniprot |
| Ins2 | uniprot |
| Egf | uniprot |
| Fgf1 | uniprot |
| Fgf2 | uniprot |
| Fgf3 | uniprot |
| Fgf4 | uniprot |
| Fgf5 | uniprot |
| Fgf9 | uniprot |
| Fgf14 | uniprot |
| Fgf20 | uniprot |
| Pdgfb | uniprot |
| Fgf6 | uniprot |
| Fgf11 | uniprot |
| Fgf16 | uniprot |
| Fgf22 | uniprot |
| Fgf7 | uniprot |
| Fgf12 | uniprot |
| Fgf17 | uniprot |
| Fgf23 | uniprot |
| Fgf8 | uniprot |
| Fgf13 | uniprot |
| Fgf18 | uniprot |
| Pdgfa | uniprot |
| Fgf10 | uniprot |
| Fgf15 | uniprot |
| Fgf21 | uniprot |
| Fgfr1 | uniprot |
| Fgfr3 | uniprot |
| Fgfr2 | uniprot |
| Fgfr4 | uniprot |
| Pdgfra | uniprot |
| Pdgfrb | uniprot |
| Sos2 | uniprot |
| Rras | uniprot |
| Rras2 | uniprot |
| Mras | uniprot |
| Hras1 | uniprot |
| Nras | uniprot |
| Kras | uniprot |
| Pik3r4 | uniprot |
| Pik3c2a | uniprot |
| Pik3c2b | |
| Pik3c2g | uniprot |
| Pik3c3 | uniprot |
| Pik3ca | uniprot |
| Pik3cb | uniprot |
| Pik3cd | uniprot |
| Pik3cg | uniprot |
| 9330140K16Rik | |
| Pik3r2 | uniprot |
| Pik3r1 | uniprot |
| Pik3r3 | uniprot |
| Raf1 | uniprot |
| Braf | uniprot |
| Map2k2 | uniprot |
| Mapk3 | uniprot |
| Mapk4 | uniprot |
| Mapk6 | uniprot |
| Dock1 | uniprot |
| Chrm2 | uniprot |
| Chrm3 | uniprot |
| Chrm4 | uniprot |
| Bdkrb2 | uniprot |
| Bdkrb1 | uniprot |
| Chrm5 | uniprot |
| Rock2 | uniprot |
| Arhgef6 | uniprot |
| Arhgef7 | uniprot |
| Actg1 | uniprot |
| Apc | uniprot |
| Apc2 | uniprot |
| Pak1 | uniprot |
| Pak2 | uniprot |
| Pak3 | uniprot |
| Pak4 | uniprot |
| Pak6 | |
| Pak7 | uniprot |
| Pfn1 | uniprot |
| Wasf2 | uniprot |
| Baiap2 | uniprot |
| Arpc5 | uniprot |
| Actb | uniprot |
| Actg1 | uniprot |
| Abi2 | uniprot |
| Nckap1 | uniprot |
| Cyfip2 | chemical |
| Wasf1 | uniprot |
| C3orf10 | |
| Tmsb4x | uniprot |
| Vil2 | uniprot |
| Pxn | uniprot |
| Git1 | uniprot |
| Rdx | uniprot |
| Vil1 | uniprot |
| Slc9a1 | uniprot |
| Pip5k2a | uniprot |
| Msn | uniprot |
| Pip5k1a | uniprot |
| Pip5k1b | uniprot |
| Pip5k2b | uniprot |
| Pip5k1c | uniprot |
| Diap1 | uniprot |
| Pfn1 | uniprot |
| Pip5k2c | |
| Pip5kl1 | |
| Vcl | uniprot |
| Actn1 | uniprot |
| Ppp1r12a | uniprot |
| Mylk | uniprot |
| Pip5k2a | uniprot |
| Limk1 | uniprot |
| Myl1 | uniprot |
| Cfl1 | uniprot |
| Myl3 | uniprot |
| Ssh1 | uniprot |
| Cfl2 | uniprot |
| Ssh2 | uniprot |
| Ssh3 | uniprot |
| Vcl | uniprot |
| Gsn | uniprot |
| Myh10 | uniprot |
| Actg1 | uniprot |
| Actb | uniprot |
| P101-pi3k | |
| Growth Factors | |
| Growth Factor (GF) | |
| RTK | |
| RTK | |
| RAS | uniprot |
| Ras | uniprot |
| PI3K | uniprot |
| PI3K | uniprot |
| Bradykinin | uniprot |
| Acetylcholine | hmdbid:HMDB00895 |
| Chemotactic factor | |
| LPS | CHEBI:16412 |
| Chemotactic factor | |
| PIP3 | uniprot |
| Actin | uniprot |
| polymerization | chemical |
| Focal adhesion | |
| assembly | |
| PIP2 | uniprot |
| PIP2 | uniprot |
| ? | |
| Stabilization | |
| of actin | |
| Lamellipodia | |
| -p | |
| +p | |
| Actin polymerization | |
| stress fiber | |
| Integrin-mediated | |
| cell adhesion | |
| Actomyosin | enzyme |
| assembly contraction | |
| Focal complex | |
| assembly | |
| Integrin-mediated | |
| cell adhesion | |
| stress fiber | |
| Gene Expression | |
| Cadherin-mediated | |
| cell adhesion | |
| Filipodia | |
| MAPK Signaling | |
| pathway | |
| Actin polymerization |
| Tbp | uniprot |
| Gtf2b | uniprot |
| Taf5 | uniprot |
| Taf6 | uniprot |
| Taf7 | uniprot |
| Taf9 | uniprot |
| Ilk | uniprot |
| Taf12 | uniprot |
| Taf13 | uniprot |
| Gtf2e1 | uniprot |
| Gtf2a2 | uniprot |
| Gtf2f2 | uniprot |
| Gtf2e2 | uniprot |
| Cdk7 | uniprot |
| Gtf2h1 | uniprot |
| Gtf2h2 | uniprot |
| Gtf2h3 | uniprot |
| Gtf2h4 | uniprot |
| Ercc3 | uniprot |
| Ercc2 | uniprot |
| Rpo1-2 | uniprot |
| Polr2a | uniprot |
| Polr2f | uniprot |
| Polr2c | uniprot |
| Polr2e | uniprot |
| Polr2k | uniprot |
| Polr3d | uniprot |
| Polr3e | uniprot |
| Polr3k | uniprot |
| Rpo1-4 | uniprot |
| Rpo1-1 | uniprot |
| Polr2i | uniprot |
| Polr2g | uniprot |
| Polr2h | uniprot |
| Polr2j | uniprot |
| Rpo1-3 | uniprot |
| Polr2b | uniprot |
| Ccnh | uniprot |
| Mnat1 | uniprot |
| Polr3b | uniprot |
| Polr3h | uniprot |
| TATA | |
| 5 | |
| 3 | |
| 3 | |
| 5 | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| TATA | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| dsDNA | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| 5 | |
| Primary RNA transcript | |
| RNA polymerase II | enzyme |
| (mRNA, snRNPs) | |
| RNA polymerase I | enzyme |
| (large ribosomal RNAs) | |
| RNA polymerase III | enzyme |
| (small stable RNAs) | |
| cell growth | |
| Gene Regulatory Proteins | |
| (recognize surface DNA geometry) | |
| TFIID | uniprot |
| TFIIB | uniprot |
| Transcription Initiation Factors (TIFs) | |
| TFIIE | |
| TFIIA | |
| TFIIF | |
| TFIID | uniprot |
| TFIIB | uniprot |
| TFIIH | |
| TFIIF | |
| TATA | |
| TFIIF | |
| RNA pol II | |
| TFIIH | |
| TFIIE | |
| TATA Box binding | |
| protein | CHEBI:16541 |
| Steps 1) TBP binds TATA box | |
| Steps 2) Association of TIFs and RNA polymerase | |
| Steps 3) DNA melting by association with TFIIH | |
| Steps 4) Transcription elongation by NTPs | |
| Steps 5) RNA elongation with CDT phosphorylation | |
| TFIIA |
| Edg5 | uniprot |
| Edg3 | uniprot |
| Edg8 | uniprot |
| Edg1 | uniprot |
| Plcb3 | uniprot |
| Akt1 | uniprot |
| Akt2 | uniprot |
| Akt3 | uniprot |
| Pik3c2g | uniprot |
| Gnai1 | uniprot |
| Gnai2 | uniprot |
| Gnai3 | uniprot |
| Racgap1 | uniprot |
| Mapk3 | uniprot |
| Mapk1 | uniprot |
| Mapk6 | uniprot |
| Mapk7 | uniprot |
| Mapk12 | uniprot |
| Smpd2 | uniprot |
| Asah2 | uniprot |
| Sphk2 | uniprot |
| Sphk1 | |
| GPCRs similar to S1P |
| Sephs1 | uniprot | |
| Sephs2 | uniprot | |
| Sp1 | uniprot | |
| Sp3 | uniprot | |
| Pou2f1 | uniprot | |
| Crem | uniprot | |
| SBP2 | uniprot | |
| eEFSec | chemical | |
| Sars | uniprot | |
| Sars2 | uniprot | |
| Pstk | uniprot | |
| UGA | ||
| Rpl30 | uniprot | |
| eEFSec | chemical | |
| SBP2 | uniprot | |
| GPX1 | uniprot | |
| GPX2 | uniprot | |
| GPX4 | uniprot | |
| DIO1 | uniprot | |
| SEPP1 | uniprot | |
| TXNRD1 | uniprot | |
| SepW1 | ||
| Sephs2 | uniprot | |
| Sep15 | uniprot | |
| DIO2 | uniprot | |
| DIO3 | uniprot | |
| GPX3 | uniprot | |
| SelH | ||
| SelI | ||
| SelK | ||
| SelM | ||
| SEPN1 | uniprot | |
| SelO | ||
| SepX1 | ||
| SelS | ||
| SelT | ||
| TXNRD2 | uniprot | |
| TXNRD3 | ||
| SelV | ||
| Secp43 | chemical | |
| Sla | uniprot | |
| TXNRD1 | uniprot | |
| TXNRD3 | ||
| TXNRD2 | uniprot | |
| Selenbp1 | uniprot | |
| Fabp1 | uniprot | |
| Selenbp1 | uniprot | |
| SBP2 | uniprot | |
| Scly | ||
| GPX6 | uniprot | |
| Cystathionine g-lyase | ||
| Nfe2l2 | uniprot | |
| Jun | uniprot | |
| Fos | uniprot | |
| p105 | uniprot | |
| p65 | uniprot | |
| MethylSelenol MeSeH | ||
| H2Se | CHEBI:16503 | |
| Selenophosphate | hmdbid:HMDB06407 | |
| Phosphoseryl-tRNA[ser](sec) | chemical | |
| Seryl-tRNA[ser](sec) | chemical | |
| Sec tRNA[ser]sec | chemical | |
| Selenocysteyl-tRNA sec | ||
| ORGANIC Se | ||
| Diet | ||
| INORGANIC Se | ||
| Selenite | CHEBI:18212 | |
| methyl transferase | ||
| demethylation | chemical | |
| coding region | ||
| AUG | ||
| STOP | ||
| Transcription Factors | ||
| nucleus | CHEBI:33252 | |
| Antioxidant | CHEBI:22586 | |
| Redox | ||
| Thyroid hormone | ||
| enzymes | ||
| signalling | ||
| metabolism | ||
| Sec | ||
| synthesis | ||
| Se transport | ||
| and storage | ||
| Protein folding | ||
| Unkown | ||
| function | ||
| Selenoproteins | ||
| SeMet | ||
| Se = Selenium, SeMet = SelenoMethionine, | ||
| SeC | ||
| Selenate | CHEBI:15075 | |
| SeMet | ||
| SeC | ||
| Selenite | CHEBI:18212 | |
| Selenate | CHEBI:15075 | |
| GSH | hmdbid:HMDB00125 | |
| Body proteins | ||
| TrX | ||
| SeC Biosynthesis | ||
| Selenium binding proteins | ||
| SeC | ||
| SeC | ||
| SeC = Selenocysteine, H2Se = Selenide, | ||
| GSH = Gluthatione, Trx = Thioredoxin |
| Itgb1 | uniprot |
| Itga1 | uniprot |
| Ptk2b | uniprot |
| Pxn | uniprot |
| Ptk2 | uniprot |
| Src | uniprot |
| Pten | uniprot |
| Pxn | uniprot |
| Ptk2 | uniprot |
| Src | uniprot |
| Ptk2b | uniprot |
| Rasa1 | uniprot |
| Pik3ca | uniprot |
| Gab1 | uniprot |
| Ptpn11 | uniprot |
| Grb2 | uniprot |
| Stat3 | uniprot |
| Sos2 | uniprot |
| Crkl | uniprot |
| Crk | uniprot |
| Dock1 | uniprot |
| Rapgef1 | chemical |
| Rap1a | uniprot |
| Rap1b | uniprot |
| Ras | uniprot |
| Mapk8 | uniprot |
| Map4k1 | uniprot |
| Elk1 | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Jun | uniprot |
| Fos | uniprot |
| Pak1 | uniprot |
| Met | |
| Hgf | uniprot |
| P | |
| P | |
| P | |
| Trancription | |
| Transcription | |
| AP-1 | uniprot |
| Transcription | |
| of Cox2 | |
| Anoikis | |
| AKT Pathway | |
| Actin | uniprot |
| RHO | uniprot |
| Pathway | |
| RAC1 | uniprot |
| Pathway | |
| CDC42 | uniprot |
| Pathway | |
| Changes in Cytoskeleton | |
| and Cell mobility | |
| Extracellular | |
| Cytoplasm | |
| Right Click for Comments |
| Cnr1 | uniprot |
| Cnr2 | uniprot |
| Edg1 | uniprot |
| Edg2 | uniprot |
| Edg3 | uniprot |
| Edg6 | uniprot |
| Mtnr1a | uniprot |
| Mtnr1b | uniprot |
| Ptafr | uniprot |
| Ptgdr | uniprot |
| Ptger1 | uniprot |
| Ptger2 | uniprot |
| Ptger3 | uniprot |
| Ptger4 | uniprot |
| Ptgfr | uniprot |
| Ptgir | uniprot |
| Tbxa2r | uniprot |
| Edg4 | uniprot |
| Edg5 | uniprot |
| Prostanoids | CHEBI:26347 |
| Melatonin | hmdbid:HMDB01389 |
| Platelet Activating | |
| Lysophosphatidic | chemical |
| Acid | CHEBI:37527 |
| Cannabinoid | chemical |
| Gq/G11 Pathway | |
| Gq/G11 Pathway | |
| Gi Pathway |
| Prkar1b | uniprot | |
| Prkca | uniprot | |
| Prkcb1 | uniprot | |
| Prkcc | uniprot | |
| Prkcd | uniprot | |
| Prkci | uniprot | |
| Prkch | uniprot | |
| Prkcm | uniprot | |
| Prkcq | uniprot | |
| Prkcz | uniprot | |
| Prkce | uniprot | |
| Prkacb | uniprot | |
| Prkar2a | uniprot | |
| Prkar2b | uniprot | |
| Prkaca | uniprot | |
| Prkar1a | uniprot | |
| Rgs1 | uniprot | |
| Rgs3 | uniprot | |
| Rgs4 | uniprot | |
| Rgs5 | uniprot | |
| Rgs6 | uniprot | |
| Rgs7 | uniprot | |
| Rgs9 | uniprot | |
| Rgs10 | uniprot | |
| Rgs11 | uniprot | |
| Rgs14 | uniprot | |
| Rgs16 | uniprot | |
| Rgs17 | uniprot | |
| Rgs18 | uniprot | |
| Rgs19 | uniprot | |
| Rgs20 | uniprot | |
| Rgs2 | uniprot | |
| Gabpb1 | uniprot | |
| Sp1 | uniprot | |
| Nfkb1 | uniprot | |
| Ets2 | uniprot | |
| Igfbp1 | uniprot | |
| Igfbp2 | uniprot | |
| Igfbp4 | uniprot | |
| Adm | uniprot | |
| Oxtr | uniprot | |
| Igfbp6 | uniprot | |
| Lgr7 | ||
| Nos1 | uniprot | |
| Crh | uniprot | |
| Igfbp3 | uniprot | |
| Crhr1 | uniprot | |
| Rln1 | uniprot | |
| Nos3 | uniprot | |
| Fos | uniprot | |
| Oxt | uniprot | |
| Ywhaz | uniprot | |
| Ywhae | uniprot | |
| Ywhah | uniprot | |
| Ywhag | uniprot | |
| Sfn | uniprot | |
| Ywhaq | uniprot | |
| Gja1 | uniprot | |
| Il1b | uniprot | |
| Il6 | uniprot | |
| Gnaq | uniprot | |
| Cmkor1 | uniprot | |
| Admr | uniprot | |
| Oxtr | uniprot | |
| Jun | uniprot | |
| Pde4b | uniprot | |
| Pde4d | uniprot | |
| Camk2d | uniprot | |
| Ywhab | uniprot | |
| Calm1 | uniprot | |
| Camk2b | uniprot | |
| Gabpa | uniprot | |
| Camk2a | uniprot | |
| Maff | uniprot | |
| Lgr8 | uniprot | |
| Igfbp5 | uniprot | |
| Cnn1 | uniprot | |
| Plcb3 | uniprot | |
| Cnn2 | uniprot | |
| Myl4 | uniprot | |
| Myl2 | uniprot | |
| Guca2a | uniprot | |
| Guca2b | uniprot | |
| Gucy2e | uniprot | |
| Gucy1a3 | uniprot | |
| Gprk5 | uniprot | |
| Gprk6 | uniprot | |
| Gnb1 | uniprot | |
| Gnb2 | uniprot | |
| Gnb3 | uniprot | |
| Gnb4 | uniprot | |
| Gnb5 | uniprot | |
| Gngt1 | uniprot | |
| Gng2 | uniprot | |
| Gng3 | uniprot | |
| Gng4 | uniprot | |
| Gng7 | uniprot | |
| Gng8 | uniprot | |
| Gng12 | uniprot | |
| Gng13 | uniprot | |
| Gng5 | uniprot | |
| Gng11 | uniprot | |
| Atf2 | uniprot | |
| Atf3 | uniprot | |
| Creb3 | uniprot | |
| Atf5 | uniprot | |
| Atf4 | uniprot | |
| Atf1 | uniprot | |
| Creb1 | uniprot | |
| Gprk2l | uniprot | |
| Gnas | uniprot | |
| Calm2 | uniprot | |
| Pkia | uniprot | |
| Pkib | uniprot | |
| Pkig | uniprot | |
| Calca | uniprot | |
| Crcp | uniprot | |
| Calm3 | uniprot | |
| Crebl1 | uniprot | |
| Itpr2 | uniprot | |
| Itpr3 | uniprot | |
| Dgkz | uniprot | |
| Plcd1 | uniprot | |
| Plcg1 | uniprot | |
| Plcg2 | uniprot | |
| Plcb3 | uniprot | |
| Gsto1 | uniprot | |
| Ryr3 | ||
| Atp2a2 | uniprot | |
| Arrb1 | uniprot | |
| Arrb2 | uniprot | |
| Cacnb3 | uniprot | |
| Slc8a1 | uniprot | |
| Cald1 | uniprot | |
| Acta1 | uniprot | |
| Acta2 | uniprot | |
| Actb | uniprot | |
| Actc1 | uniprot | |
| Actg1 | uniprot | |
| Ramp1 | uniprot | |
| Ramp2 | uniprot | |
| Ramp3 | uniprot | |
| Camk2g | uniprot | |
| Mylk2 | uniprot | |
| Ryr1 | ||
| Atp2a3 | uniprot | |
| Ryr2 | ||
| Myl1 | uniprot | |
| Myl3 | uniprot | |
| Myl9 | uniprot | |
| Nppa | uniprot | |
| Crem | uniprot | |
| Gnai2 | uniprot | |
| Itpr1 | uniprot | |
| Adcy4 | uniprot | |
| Adcy3 | uniprot | |
| Adcy2 | uniprot | |
| Adcy1 | uniprot | |
| Adcy5 | uniprot | |
| Adcy6 | uniprot | |
| Adcy7 | uniprot | |
| Adcy8 | uniprot | |
| Adcy9 | uniprot | |
| Protein Kinase A | uniprot | |
| Protein Kinase C | uniprot | |
| TR | ||
| TR = Transcriptional Regulation | ||
| note: see gene backpages for references | ||
| Regulators of G-protein | ||
| Signaling | ||
| IGFBP | ||
| Adenylyl Cyclases | ||
| Activation Via CRH and cAMP | ||
| PKC inhibitor Protein-1 | ||
| Pathways of Myometrial Relaxation | ||
| Pathways of Myometrial Contraction | ||
| cAMP | hmdbid:HMDB00058 | |
| cGMP | hmdbid:HMDB01314 | |
| Predicted OT-R | ||
| Predicted Cxn43 | ||
| Ets complex | ||
| Pge2 | chemical | |
| Nucleus | CHEBI:33252 | |
| AP-1 complex | ||
| Myometrial Relaxation | ||
| Adenylyl Cyclases | enzyme | uniprot |
| PKA | enzyme | |
| Myometrial Contraction | ||
| PKC | enzyme | uniprot |
| PKC inhibitor 1 | ||
| RGS | hmdbid:HMDB00131 | uniprot |
| G | ||
| bg | ||
| bg | ||
| DAG | uniprot | |
| G | ||
| Calcium Mobilization | ||
| IGFBP | ||
| TR | ||
| NO | ||
| Transcriptional | ||
| CRE-Transcription Factors | ||
| bg | ||
| G | ||
| IP3 | ||
| Pip2 | chemical | |
| GRK | ||
| GRK | ||
| Cell Growth | ||
| GPCR Kinase | enzyme | |
| PKA Inhibitors | ||
| Regulators | ||
| Phospholipase-C | chemical | |
| Camk2 | ||
| IP3 Receptor | ||
| SR | ||
| IP3 Receptor | ||
| Calmodulin | uniprot | |
| Phospholipase-C | chemical | |
| CAM-Kinase 2 | ||
| beta Arrestin | ||
| beta Arrestin | ||
| beta Arrestin | ||
| Calcium Influx | ||
| + | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| Na | ||
| MAPK | enzyme | uniprot |
| 2+ | ||
| Mg | ||
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| Mlck | ||
| P | ||
| - | ||
| ATP | hmdbid:HMDB00538 | |
| Pi + ADP | ||
| RAMP | uniprot | |
| RAMP | uniprot | |
| Ca++/Calmodulin | ||
| Ryr | ||
| Ryanodine | chemical | |
| Receptor (Ryr) | ||
| Myosin Light | ||
| Myosin Light Chain | ||
| Chain |
| Hmgcr | uniprot | |
| Cyp7a1 | uniprot | |
| Soat1 | uniprot | |
| Mttp | uniprot | |
| Dgat1 | uniprot | |
| Ldlr | uniprot | |
| Lrp1 | uniprot | |
| Lpl | uniprot | |
| Lipc | uniprot | |
| Cetp | chemical | |
| Lcat | uniprot | |
| Abca1 | uniprot | |
| Pltp | uniprot | |
| Apoa1 | uniprot | |
| Apoa4 | uniprot | |
| Apoc1 | uniprot | |
| Apoe | uniprot | |
| Apoc2 | uniprot | |
| Apoc3 | uniprot | |
| Scarb1 | uniprot | |
| Cell Membrane | ||
| Statin | hmdbid:HMDB05007 | |
| acetylCoA | hmdbid:HMDB01206 | uniprot |
| Cholesterol | hmdbid:HMDB00067 | |
| Cholic Acid | hmdbid:HMDB00619 | |
| Free FA | ||
| Cholesterol Ester | ||
| Phospholipid | CHEBI:16247 | |
| Triglycerides | chemical | |
| Liver cell | ||
| LDL | ||
| IDL | ||
| VLDL | ||
| HDL | ||
| Cholesterol | hmdbid:HMDB00067 | |
| Tissues | ||
| Plasma |
| Cyp17a1 | uniprot |
| Cyp17a1 | uniprot |
| Hsd3b6 | uniprot |
| F13b | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b2 | uniprot |
| Hsd3b3 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd17b1 | uniprot |
| Hsd17b2 | uniprot |
| Hsd17b3 | uniprot |
| Hsd17b4 | uniprot |
| Hsd17b7 | uniprot |
| Hsd3b4 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b2 | uniprot |
| Hsd3b3 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b4 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b2 | uniprot |
| Hsd3b3 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b4 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b2 | uniprot |
| Hsd3b3 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b4 | uniprot |
| Hydroxyprogesterone aldolase | |
| Steroid-19-Hydroxylase | chemical |
| Steroid-19-Hydroxylase | chemical |
| Hydroxyprogesterone aldolase | |
| Cholesterol | hmdbid:HMDB00067 |
| Pregnenolone | hmdbid:HMDB00253 |
| Progesterone | hmdbid:HMDB01830 |
| 17-alpha-OH-Pregnenolone | chemical |
| 17-alpha-OH-Progesterone | chemical |
| DHA | hmdbid:HMDB00077 |
| Androstenedione | hmdbid:HMDB00053 |
| Androstenediol | hmdbid:HMDB03818 |
| Testosterone | hmdbid:HMDB02998 |
| Estrone | hmdbid:HMDB01425 |
| Estradiol | hmdbid:HMDB00151 |
| ** Estradiol-17-beta DH = DHB | |
| To Mineralcorticoid Synthesis | |
| To Glucocorticoid Synthesis | |
| * | |
| * | |
| * | |
| ** | |
| Dihydrotestosterone | hmdbid:HMDB02961 |
| * | |
| * 3-beta-OH-delta-steroid DH & Steroid isomerase = |
| Myl4 | uniprot |
| Myl2 | uniprot |
| Myh6 | uniprot |
| Myh8 | uniprot |
| Acta1 | uniprot |
| Actc1 | uniprot |
| Tnni1 | uniprot |
| Tnnt2 | uniprot |
| Tpm3 | uniprot |
| Dmd | uniprot |
| Vim | uniprot |
| Tpm2 | uniprot |
| Tnni2 | uniprot |
| Tnni3 | uniprot |
| Tnnt3 | uniprot |
| Tnnt1 | uniprot |
| Tnnc1 | uniprot |
| Tnnc2 | uniprot |
| Myl3 | uniprot |
| Myl1 | uniprot |
| Myh3 | uniprot |
| Actn3 | uniprot |
| Actn2 | uniprot |
| Actn4 | uniprot |
| Tmod1 | uniprot |
| Neb | |
| Myom1 | uniprot |
| Tcap | uniprot |
| Ttn | |
| Des | |
| Tpm4 | uniprot |
| Tpm1 | uniprot |
| Mybpc3 | uniprot |
| Mybpc2 | uniprot |
| Mybpc1 | uniprot |
| Acta2 | uniprot |
| Actg1 | uniprot |
| Myl9 | uniprot |
| Myom2 | |
| Myh7 | uniprot |
| Myh4 | uniprot |
| Myh1 | uniprot |
| Casq2 | uniprot |
| 2300003C06Rik | |
| Smpx | uniprot |
| Myosin Light Chain | |
| Myosin Heavy Chain | uniprot |
| Tropomyosin | uniprot |
| Other Structural | |
| M Disk | |
| Z Disk | |
| Z Disk | |
| Myosin Binding | |
| A Model of Triggering of Striated Muscle | |
| Contraction by Ca++ | |
| Troponin-T | uniprot |
| Troponin-I | uniprot |
| Troponin-C | uniprot |
| Actin | uniprot |
| Actin | uniprot |
| Myosin Binding Site | |
| (Covered) | |
| Ca | |
| Ca | |
| Myosin Head | |
| Regulatory Proteins |
| Bdh | uniprot | |
| Acat1 | uniprot | |
| Hmgcl | uniprot | |
| Hmgcs2 | uniprot | |
| 3-Hydroxy-butyrate | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Acetoacetyl-CoA | hmdbid:HMDB01484 | |
| 3-Hydroxy-3-methylglutaryl-CoA | hmdbid:HMDB01375 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Pyruvate metabolism | ||
| Fatty acid metabolism | ||
| Sterol biosynthesis | ||
| Acetoacetate | hmdbid:HMDB00060 | |
| Fatty acid beta-oxidation | ||
| Glycolysis | ||
| (HMG-CoA cycle) | ||
| * pathway-regulated enzymes: HMG-CoA synthase, mt |
| TRA@ | |
| TRB@ | |
| Cd3g | uniprot |
| Cd3d | uniprot |
| Cd3e | uniprot |
| Cd5 | uniprot |
| Ptpn6 | uniprot |
| Nck1 | |
| Sla | uniprot |
| Syk | uniprot |
| Cbl | uniprot |
| PIK3R1 | uniprot |
| Pik3r2 | uniprot |
| Trat1 | uniprot |
| Lax1 | uniprot |
| Gab2 | uniprot |
| Shc1 | uniprot |
| Prkcq | uniprot |
| Vav1 | uniprot |
| Fyb | uniprot |
| Dusp3 | uniprot |
| Ptpn3 | |
| Ptpn12 | uniprot |
| Map2k1 | uniprot |
| Mapk1 | uniprot |
| Prkd2 | uniprot |
| Sit1 | uniprot |
| Ptpn11 | uniprot |
| MAP3K1 | uniprot |
| LOC545902 | |
| Map2k2 | uniprot |
| Mapk3 | uniprot |
| Vav3 | uniprot |
| Vav2 | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Mapk7 | uniprot |
| Jak3 | uniprot |
| Sh2d3c | uniprot |
| Bcl10 | uniprot |
| Pak1 | uniprot |
| Scap1 | |
| Scap2 | |
| Sos2 | uniprot |
| Dbnl | uniprot |
| Abl1 | uniprot |
| Rasa1 | uniprot |
| Ptpn22 | uniprot |
| Crkl | uniprot |
| Ctnnb1 | uniprot |
| Cblb | uniprot |
| Shb | uniprot |
| Src | uniprot |
| Ptk2 | uniprot |
| Akt1 | uniprot |
| Cd4 | uniprot |
| Cd8a | uniprot |
| Sh3bp2 | uniprot |
| Stat5b | uniprot |
| Cd2 | uniprot |
| Rap1a | uniprot |
| Lyn | |
| Rac2 | uniprot |
| Cd247 | uniprot |
| Cd247 | uniprot |
| Fyn | uniprot |
| Zap70 | uniprot |
| Lck | uniprot |
| Map4k1 | uniprot |
| Muc1 | uniprot |
| Tubb5 | uniprot |
| Fcrl5 | |
| SLA2 | uniprot |
| Card11 | |
| Waspip | uniprot |
| Nfam1 | uniprot |
| Def6 | chemical |
| Was | |
| Grap | uniprot |
| Grap2 | uniprot |
| Lcp2 | uniprot |
| Arhgdib | uniprot |
| Crk | uniprot |
| Dtx1 | uniprot |
| Nedd9 | uniprot |
| Rapgef1 | chemical |
| Pstpip1 | uniprot |
| Lat | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Plcg1 | uniprot |
| Pxn | uniprot |
| Arhgef7 | uniprot |
| Txk | uniprot |
| Khdrbs1 | uniprot |
| NCL | uniprot |
| Unc119 | uniprot |
| Tuba4 | uniprot |
| Itk | uniprot |
| Dnm2 | uniprot |
| Dlgh1 | uniprot |
| Creb1 | uniprot |
| Crebbp | uniprot |
| Arhgef6 | uniprot |
| Git2 | uniprot |
| Vasp | uniprot |
| ENAH | uniprot |
| Evl | uniprot |
| Cdc42 | uniprot |
| Fyb | uniprot |
| Lcp2 | uniprot |
| Nck1 | |
| Ptprc | uniprot |
| Sh2d2a | uniprot |
| WASF2 | uniprot |
| ABI1 | uniprot |
| Pag1 | uniprot |
| Rasgrp2 | |
| Cd2ap | uniprot |
| Homer3 | uniprot |
| Cebpb | uniprot |
| Ppp3cb | uniprot |
| Cabin1 | uniprot |
| Nfatc2 | uniprot |
| Itpr1 | uniprot |
| Ywhaq | uniprot |
| Jun | uniprot |
| Jun | uniprot |
| Fos | uniprot |
| Cish | uniprot |
| Dock2 | uniprot |
| Ripk2 | uniprot |
| Lime1 | uniprot |
| Acp1 | uniprot |
| Lnk | uniprot |
| Stk39 | uniprot |
| Hdac7a | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Lime1 | uniprot |
| Hdac7a | uniprot |
| BRAF | uniprot |
| Ptk2b | uniprot |
| Ptprj | uniprot |
| Cd3e | uniprot |
| Antigen | |
| Molecular association | |
| Methylation | chemical |
| Glycosylation | |
| Autophosphorylation | chemical |
| Demethylation | chemical |
| Translocation | |
| Cytoplasm | |
| Endoplasmic reticulum | |
| Endosome | |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| NU->CY | |
| D | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Accession Number: NetPath_11 | |
| ER | |
| CY | |
| EN | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Nucleus | CHEBI:33252 |
| NU | |
| Plasma membrane | |
| PM |
| Tgfb1 | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Smad2 | uniprot |
| Dab2 | uniprot |
| Smad7 | uniprot |
| Smurf1 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfb2 | uniprot |
| Arrb2 | uniprot |
| Tgfb3 | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Smad3 | uniprot |
| Strap | |
| Smad6 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfb1 | uniprot |
| Sparc | |
| Sdc2 | uniprot |
| Cd44 | uniprot |
| Ap2b1 | uniprot |
| Smad4 | uniprot |
| Zfyve9 | |
| Daxx | uniprot |
| Fkbp1a | uniprot |
| Fnta | uniprot |
| Erbb2ip | uniprot |
| Gipc1 | uniprot |
| PIK3R1 | uniprot |
| Ctnnb1 | uniprot |
| Eng | uniprot |
| Cav1 | uniprot |
| Eif3s2 | uniprot |
| Axin1 | uniprot |
| Snx6 | uniprot |
| Vdr | uniprot |
| Prkar2a | uniprot |
| Prkar1b | uniprot |
| Zfhx1a | uniprot |
| Tgif | uniprot |
| Nup214 | uniprot |
| Pik3r2 | uniprot |
| Pard3 | uniprot |
| Hgs | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr1 | uniprot |
| Tgfb1 | uniprot |
| Tgfb3 | uniprot |
| Tgfb2 | uniprot |
| Tgfb2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfb1 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfb3 | uniprot |
| Tgfb3 | uniprot |
| Lef1 | uniprot |
| Hdac1 | uniprot |
| Mef2c | uniprot |
| Mef2a | uniprot |
| Runx2 | uniprot |
| Myc | uniprot |
| Sp1 | uniprot |
| Nup153 | uniprot |
| Smad2 | uniprot |
| Nfyc | uniprot |
| Snip1 | uniprot |
| Zfhx1b | uniprot |
| Foxh1 | uniprot |
| Pcaf | chemical |
| Ep300 | |
| Cdc27 | uniprot |
| Skil | uniprot |
| Esr1 | uniprot |
| Smad4 | uniprot |
| Smad3 | uniprot |
| Rbx1 | uniprot |
| Cul1 | uniprot |
| Dvl1 | uniprot |
| Foxo3a | |
| Trp53 | uniprot |
| Trp73 | |
| SNW1 | uniprot |
| Cri2 | |
| Stambpl1 | uniprot |
| Foxo1 | uniprot |
| Atf2 | uniprot |
| Cited1 | uniprot |
| Jund1 | uniprot |
| Fos | uniprot |
| Rbl1 | uniprot |
| Anapc10 | uniprot |
| Anapc1 | uniprot |
| Anapc4 | uniprot |
| Cdc27 | uniprot |
| Cdc16 | uniprot |
| Cdc23 | uniprot |
| Anapc2 | uniprot |
| Anapc5 | uniprot |
| Anapc7 | uniprot |
| E2f5 | uniprot |
| Hnf4a | uniprot |
| E2f4 | |
| Anapc1 | uniprot |
| Anapc2 | uniprot |
| Anapc5 | uniprot |
| Anapc7 | uniprot |
| Cdc27 | uniprot |
| Cdc16 | uniprot |
| Cdc23 | uniprot |
| Anapc4 | uniprot |
| Jun | uniprot |
| Smad3 | uniprot |
| Ski | |
| Ar | |
| Ctcf | uniprot |
| Atf3 | uniprot |
| Esr1 | uniprot |
| Ets1 | uniprot |
| Axin2 | uniprot |
| Mllt7 | uniprot |
| Junb | uniprot |
| Fosb | uniprot |
| Trap1 | uniprot |
| Stk11ip | |
| Stk11 | uniprot |
| Sumo1 | uniprot |
| Hoxa9 | uniprot |
| Dcp1a | uniprot |
| Cops5 | uniprot |
| Mapk14 | uniprot |
| Map3k7 | uniprot |
| Smad7 | uniprot |
| Smurf1 | uniprot |
| Yap1 | uniprot |
| Map2k6 | uniprot |
| Map2k3 | uniprot |
| Smurf2 | |
| Smad7 | uniprot |
| Smurf2 | |
| Strap | |
| Snx6 | uniprot |
| Snx1 | uniprot |
| Snx2 | uniprot |
| Snx4 | uniprot |
| CDK2 | uniprot |
| Ccne1 | uniprot |
| Tfdp1 | uniprot |
| Smad3 | uniprot |
| Tfdp2 | uniprot |
| Cdkn1a | uniprot |
| Nfya | uniprot |
| Nfyb | uniprot |
| Foxg1 | uniprot |
| Crebbp | uniprot |
| Ncoa1 | uniprot |
| Fzr1 | uniprot |
| Rbl2 | uniprot |
| Ppp2r2a | uniprot |
| Anapc10 | uniprot |
| Rock1 | uniprot |
| Cdc25a | uniprot |
| Map3k7ip1 | uniprot |
| Xpo1 | uniprot |
| Hspa8 | uniprot |
| Rock1 | uniprot |
| Rbl2 | uniprot |
| E2f4 | |
| E2f4 | |
| E2f4 | |
| Rbl1 | uniprot |
| Kpnb1 | uniprot |
| Smad3 | uniprot |
| Kpnb1 | uniprot |
| Smad3 | uniprot |
| Tfdp2 | uniprot |
| Tfdp2 | uniprot |
| Smad4 | uniprot |
| Smad4 | uniprot |
| Dcp1a | uniprot |
| Smad2 | uniprot |
| Smad2 | uniprot |
| Rb1 | uniprot |
| Rb1 | uniprot |
| Mapk8 | uniprot |
| Cdk6 | uniprot |
| Cdk4 | uniprot |
| Ccnd1 | uniprot |
| Prkcd | uniprot |
| PRKCG | uniprot |
| Prkcb1 | uniprot |
| Rb1 | uniprot |
| Pias1 | uniprot |
| Pias2 | uniprot |
| Ube2d2 | uniprot |
| Ube2d1 | uniprot |
| Ube2d3 | uniprot |
| Skp1a | uniprot |
| Btrc | chemical |
| Rbx1 | uniprot |
| Cul1 | uniprot |
| Camk2a | uniprot |
| Camk2d | uniprot |
| Camk2g | uniprot |
| Camk2b | uniprot |
| E2f5 | uniprot |
| Skp1a | uniprot |
| Cul1 | uniprot |
| Rbx1 | uniprot |
| Btrc | chemical |
| Smad3 | uniprot |
| Rbl1 | uniprot |
| Smad4 | uniprot |
| Smad3 | uniprot |
| E2f4 | |
| E2f5 | uniprot |
| Tfdp1 | uniprot |
| Rbl1 | uniprot |
| Smad4 | uniprot |
| E2f4 | |
| Tfdp1 | uniprot |
| Smad3 | uniprot |
| E2f5 | uniprot |
| E2f5 | uniprot |
| E2f5 | uniprot |
| Rbl1 | uniprot |
| Cdc2a | uniprot |
| Ccnb2 | uniprot |
| Mapk14 | uniprot |
| Mapk8 | uniprot |
| Gene Symbol | |
| Acvrl1 | uniprot |
| NU -> CY | |
| NU -> CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Molecular association | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| Translocation | |
| CY | |
| Cytoplasm | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondria | |
| NU | |
| Nucleus | CHEBI:33252 |
| PM | |
| Plasma membrane | |
| Accession Number: NetPath_7; cellmap:7 |
| Tgfbr3 | uniprot |
| Eng | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr1 | uniprot |
| Inhba | uniprot |
| Bmp4 | uniprot |
| Ltbp1 | uniprot |
| Fst | uniprot |
| Nog | uniprot |
| Itgb6 | uniprot |
| Thbs1 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr1 | uniprot |
| Fkbp1a | uniprot |
| Sara1 | uniprot |
| Spp1 | uniprot |
| Zfhx1b | uniprot |
| Smad1 | uniprot |
| Smad5 | uniprot |
| Smad9 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| Smad6 | uniprot |
| Smad7 | uniprot |
| Ifng | uniprot |
| Tgfb1 | uniprot |
| Bmp4 | uniprot |
| Tnf | uniprot |
| Egf | uniprot |
| Stat1 | uniprot |
| Smad2 | uniprot |
| Smad1 | uniprot |
| Nfkb1 | uniprot |
| Mapk3 | uniprot |
| Hras1 | uniprot |
| Smad4 | uniprot |
| Wnt11 | uniprot |
| Lif | uniprot |
| Tnf | uniprot |
| Catnb | uniprot |
| Jak1 | uniprot |
| Mapk9 | uniprot |
| Runx2 | uniprot |
| Runx3 | uniprot |
| Lef1 | uniprot |
| Stat3 | uniprot |
| Jun | uniprot |
| Tcfe3 | uniprot |
| Crebbp | uniprot |
| Tgif | uniprot |
| Skil | uniprot |
| Ski | |
| Serpine1 | uniprot |
| Fos | uniprot |
| Bambi | uniprot |
| Tgfb1 | uniprot |
| P300 | uniprot |
| QAZ | |
| Foxh1 | uniprot |
| ligands: | |
| Co-smads | |
| Repressors | |
| Cofactors | CHEBI:23357 |
| Rsmads | |
| R-Smads | |
| Cofactor | CHEBI:23357 |
| Accessory receptors | |
| TGFb | |
| Co-Smads |
| Traf6 | uniprot |
| FLNA | uniprot |
| Psmc3 | uniprot |
| Rel | uniprot |
| Nfkb1 | uniprot |
| Cyld | uniprot |
| Ikbkg | uniprot |
| Tbk1 | uniprot |
| Ddx48 | uniprot |
| Psmd6 | uniprot |
| Traip | uniprot |
| Trpc4ap | uniprot |
| 2810055G22Rik | |
| Tnfrsf8 | uniprot |
| Casp8ap2 | uniprot |
| Hspb1 | uniprot |
| Tnfrsf1b | uniprot |
| Tnfrsf1b | uniprot |
| Tnfrsf1a | uniprot |
| Tnfrsf1a | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Prkcz | uniprot |
| Rela | uniprot |
| Prkaca | uniprot |
| Ppp2ca | uniprot |
| Ube2d3 | uniprot |
| LOC382523 | |
| Ube2d2 | uniprot |
| Casp7 | uniprot |
| Map3k2 | uniprot |
| Capn3 | uniprot |
| Cdc34 | uniprot |
| Nfkbia | uniprot |
| Traf2 | uniprot |
| Tradd | chemical |
| Psmd7 | uniprot |
| Psmd3 | uniprot |
| Psmd12 | uniprot |
| Nfkb2 | uniprot |
| Psmd13 | uniprot |
| T2bp | |
| Psmd1 | uniprot |
| RPL30 | uniprot |
| Relb | uniprot |
| Smarcc1 | uniprot |
| Cdc37 | uniprot |
| RPL6 | uniprot |
| Smarca4 | |
| Hdac1 | uniprot |
| Hdac2 | uniprot |
| Kcnq1 | uniprot |
| Kpna3 | uniprot |
| Psmb5 | uniprot |
| Faf1 | uniprot |
| Psmc1 | uniprot |
| Stat1 | uniprot |
| Fadd | uniprot |
| Psmc2 | uniprot |
| Papola | uniprot |
| Bcl3 | uniprot |
| Pml | uniprot |
| IQGAP2 | uniprot |
| Ddx3x | uniprot |
| Glg1 | uniprot |
| Usp11 | uniprot |
| BCL7A | uniprot |
| Gsk3b | uniprot |
| Smarcb1 | uniprot |
| Traf1 | uniprot |
| Tbk1 | uniprot |
| Smarce1 | uniprot |
| Cops3 | uniprot |
| Hdac6 | uniprot |
| Smarcc2 | uniprot |
| Unc5cl | chemical |
| Pkn1 | uniprot |
| KPNA2 | uniprot |
| Kpna6 | uniprot |
| 4921526G09Rik | |
| Pias3 | uniprot |
| Peg3 | uniprot |
| Cav1 | uniprot |
| Gtf2i | uniprot |
| Txlna | uniprot |
| Map3k3 | uniprot |
| Ywhag | uniprot |
| Gab1 | uniprot |
| Pfdn2 | uniprot |
| Ywhab | uniprot |
| Ywhae | uniprot |
| Ywhah | uniprot |
| Ywhaq | uniprot |
| Ywhaz | uniprot |
| Tnfaip3 | uniprot |
| Tnip1 | uniprot |
| Tnip2 | |
| Akt2 | uniprot |
| Chuk | uniprot |
| Akt1 | uniprot |
| Src | uniprot |
| Rnf25 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Fbxw11 | |
| Csnk2a1 | uniprot |
| Csnk2a2 | uniprot |
| Csnk2b | uniprot |
| Ripk1 | uniprot |
| CASP10 | uniprot |
| Casp8 | uniprot |
| Traf3 | uniprot |
| Birc2 | uniprot |
| Birc3 | uniprot |
| Ptk2 | uniprot |
| Cflar | uniprot |
| Casp3 | uniprot |
| Nfkbia | uniprot |
| Cul1 | uniprot |
| Skp1a | uniprot |
| Btrc | chemical |
| E430034L04Rik | |
| Rela | uniprot |
| Cd3eap | uniprot |
| Nfkbib | uniprot |
| Lrpprc | |
| MCC | |
| Mtif2 | uniprot |
| Nkiras1 | uniprot |
| Nkiras2 | uniprot |
| Pdcd2 | uniprot |
| Rpo1-4 | uniprot |
| Rpo1-2 | uniprot |
| Rpo1-3 | uniprot |
| Polr2h | uniprot |
| Polr2l | uniprot |
| Ikbkb | uniprot |
| 2610301G19Rik | |
| Ikbkg | uniprot |
| Chuk | uniprot |
| RASAL2 | uniprot |
| Polr1e | uniprot |
| Rpo1-1 | uniprot |
| Nfkbie | uniprot |
| Nfkbia | uniprot |
| Commd1 | uniprot |
| Mcm5 | uniprot |
| Mcm7 | uniprot |
| Sumo1 | uniprot |
| Ikbkap | chemical |
| Hsp90ab1 | uniprot |
| Za20d2 | uniprot |
| Crebbp | uniprot |
| Fkbp5 | uniprot |
| Hsp90aa1 | uniprot |
| Ptpn11 | uniprot |
| Map3k14 | uniprot |
| Fbl | uniprot |
| Rpl4 | uniprot |
| Ktn1 | uniprot |
| Rpl8 | uniprot |
| Rps11 | uniprot |
| RPS13 | uniprot |
| LOC622602 | |
| Azi2 | |
| Ikbke | uniprot |
| Tank | |
| MAP3K1 | uniprot |
| Wdr68 | uniprot |
| Ube2i | uniprot |
| Map3k8 | uniprot |
| Map3k3 | uniprot |
| Map2k5 | uniprot |
| Mark2 | uniprot |
| Rps6ka5 | uniprot |
| Nfkbiz | |
| Usp2 | uniprot |
| Nsmaf | uniprot |
| Gnb2l1 | uniprot |
| Nalp4e | |
| Cradd | uniprot |
| Casp2 | uniprot |
| Tnfrsf11a | uniprot |
| Akap8 | uniprot |
| Actl6a | uniprot |
| Ppp1r13l | uniprot |
| Dpf2 | uniprot |
| Ripk3 | uniprot |
| Ripk2 | uniprot |
| Pebp1 | uniprot |
| Nr2c2 | uniprot |
| Nr2c2 | uniprot |
| Map3k7ip1 | uniprot |
| Map3k7ip2 | uniprot |
| Akp2 | uniprot |
| Tnfrsf1a | uniprot |
| Tnf | uniprot |
| Dap | uniprot |
| Fancd2 | uniprot |
| Birc2 | uniprot |
| Traf2 | uniprot |
| Ripk1 | uniprot |
| Tradd | chemical |
| Tnfrsf1b | uniprot |
| Birc3 | uniprot |
| Traf1 | uniprot |
| Traf2 | uniprot |
| Bag4 | uniprot |
| RPS6KB1 | uniprot |
| Traf4 | uniprot |
| Relb | uniprot |
| Rela | uniprot |
| Rel | uniprot |
| Traf4 | uniprot |
| Nfkb1 | uniprot |
| Gene Symbol | |
| Gene | |
| Gene | |
| Gene | |
| Gene | |
| NU | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| CY | |
| EC | |
| EN | |
| ER | |
| GO | |
| MT | |
| PM | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Ubiquitination | |
| Inhibition | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Activation | chemical |
| Recruitment | |
| Control | |
| Translocation | |
| Cytoplasm | |
| Extracellular | |
| Endosome | |
| Endoplasmic reticulum | |
| Golgi apparatus | |
| CY ->NU | |
| CY ->NU | |
| CY ->NU | |
| CY ->NU | |
| CY ->NU | |
| Receptor | |
| Ligand | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Molecular association | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| D | |
| Autophosphorylation | chemical |
| Mitochondrion | |
| Nucleus | CHEBI:33252 |
| Plasma membrane | |
| Accession Number: NetPath_9; cellmap:9 | |
| Molecule in the pathway |
| Eif3s8 | uniprot |
| Eif3s9 | uniprot |
| Sui1-rs1 | uniprot |
| Eif2s1 | uniprot |
| Eif2s3y | uniprot |
| Eif2s3x | uniprot |
| Eif3s1 | uniprot |
| Eif3s2 | uniprot |
| Eif3s3 | uniprot |
| Eif3s4 | uniprot |
| Eif3s5 | uniprot |
| Eif3s6 | uniprot |
| Eif3s7 | uniprot |
| Eif3s10 | uniprot |
| Pabpc1 | uniprot |
| Eif4ebp1 | uniprot |
| Eif4ebp2 | uniprot |
| Eif4ebp3 | uniprot |
| Paip1 | uniprot |
| Eif2s2 | uniprot |
| Etf1 | uniprot |
| eRF3 | |
| Eef1a2 | uniprot |
| Eef1b2 | uniprot |
| Eef1g | uniprot |
| Eef1d | uniprot |
| Eef1a1 | uniprot |
| Eef2k | uniprot |
| Pabpc2 | chemical |
| Eif2b1 | uniprot |
| Eif2b2 | uniprot |
| Eif2b3 | uniprot |
| Eif2b4 | uniprot |
| Eif2b5 | uniprot |
| Itgb4bp | uniprot |
| Eif5a | uniprot |
| Eif5 | uniprot |
| Eif4g1 | uniprot |
| Eif4g2 | uniprot |
| Eif4e | uniprot |
| Eif4a1 | uniprot |
| Eif4a2 | uniprot |
| Eif4b | uniprot |
| Eif1a | uniprot |
| Prkr | uniprot |
| Eif2ak1 | uniprot |
| Wbscr1 | uniprot |
| Eef2 | uniprot |
| Eif2ak3 | uniprot |
| IF2 | uniprot |
| Eif4g3 | uniprot |
| AAAAAAAAAAAAAAA | |
| m7G | |
| AUG | |
| mRNA | CHEBI:33699 |
| Guanine Nucleotide Exchange | |
| Recruitment of 43S | |
| scanning | |
| Cap Binding Complex | |
| 43S Pre-initiation Complex | |
| Recruitment of 60S subunit | |
| and first peptide bond | |
| 60S Subunit | |
| 40S Subunit | |
| Pre-initiation Complex | |
| Translocation | |
| Binds aminoacyl-tRNA | |
| Termination | chemical |
| Elongation | |
| Initiation | chemical |
| Gpd1 | uniprot |
| Gyk | uniprot |
| Gpam | uniprot |
| Gnpat | uniprot |
| Agps | uniprot |
| AYR1 | uniprot |
| Agpat1 | uniprot |
| Agpat2 | uniprot |
| Agpat3 | uniprot |
| Agpat4 | uniprot |
| Agpat5 | uniprot |
| Ppap2a | uniprot |
| Ppap2b | uniprot |
| Ppap2c | uniprot |
| Dgat1 | uniprot |
| Gk2 | |
| Dgat2 | uniprot |
| Mgat1 | uniprot |
| Mgat2 | uniprot |
| Mgat3 | uniprot |
| Lpl | uniprot |
| Lipe | uniprot |
| Lipc | uniprot |
| Lipf | uniprot |
| Pnpla2 | chemical |
| Dihydroxyacetonephosphate | hmdbid:HMDB01473 |
| Glycerol | hmdbid:HMDB00131 |
| Glycerol-3-phosphate | hmdbid:HMDB00126 |
| Fatty Acyl CoA | |
| See Fatty Acid Synthesis MAPP | |
| Lysophosphatic Acid | chemical |
| Dihydroxyacetone phosphate | hmdbid:HMDB01473 |
| Fatty acyl CoA | |
| acyldihydroxyacetonephosphate | chemical |
| See Fatty Acid Synthesis MAPP | |
| Phosphatic acid | chemical |
| Only 1 of these enzymes is needed | |
| Diacylglycerol | CHEBI:18035 CHEBI:18035 |
| Only 1 of these enzymes is needed | |
| Triacylglycerol | chemical |
| Fatty Acyl CoA | |
| Monoacylglycerol | CHEBI:17408 CHEBI:17408 |
| Degradation | |
| Path |
| 2.6.1.27 | ||
| 1.4.3.2 | ||
| Indo | ||
| Cyp2j6 | uniprot | |
| Asmt | chemical | |
| Hrmt1l2 | uniprot | |
| Aanat | uniprot | |
| Indo | ||
| Mdm2 | uniprot | |
| Maob | uniprot | |
| Ddc | uniprot | |
| 2.6.1.27 | ||
| Ddc | uniprot | |
| Indo | ||
| 2.6.1.27 | ||
| 1.13.11.17 | ||
| 1.7.3.2 | ||
| 1.14.16.- | ||
| 3.5.1.49 | ||
| 3.5.1.9 | ||
| 1.13.11.23 | ||
| 1.14.16.3 | ||
| Acat1 | uniprot | |
| Hadh2 | uniprot | |
| Echs1 | uniprot | |
| Gcdh | uniprot | |
| Ogdh | uniprot | |
| 1.2.1.32 | ||
| Acmsd | uniprot | |
| Haao | uniprot | |
| Kynu | uniprot | |
| 1.14.13.9 | ||
| Kynu | uniprot | |
| Kynu | uniprot | |
| Tdo2 | uniprot | |
| 4.1.99.1 | ||
| Tph1 | uniprot | |
| Wars | ||
| 1.13.99.3 | ||
| Cat | ||
| Aadat | uniprot | |
| Aadat | uniprot | |
| 1.10.3.4 | ||
| Maob | uniprot | |
| 1.13.11.- | ||
| 1.5.1.- | ||
| Dhcr24 | ||
| 1.13.11.10 | ||
| 1.3.1.18 | ||
| 1.14.99.2 | ||
| 1.13.12.3 | ||
| Ddc | uniprot | |
| Maob | uniprot | |
| 4.1.1.43 | ||
| 1.2.3.7 | ||
| Aldh3a2 | uniprot | |
| 2.1.1.47 | ||
| 1.1.1.110 | ||
| Cyp7b1 | uniprot | |
| Afmid | uniprot | |
| Aldh3a2 | uniprot | |
| Aox1 | uniprot | |
| 1.2.1.- | ||
| 4432411E13Rik | ||
| Hrmt1l2 | uniprot | |
| Hrmt1l2 | uniprot | |
| Maob | uniprot | |
| 4.2.1.84 | ||
| 3.5.1.4 | ||
| 3.5.5.1 | ||
| 3.2.1.147 | ||
| 1.1.1.190 | ||
| 1.1.1.191 | ||
| Abp1 | uniprot | |
| 2.1.1.49 | ||
| Inmt | uniprot | |
| 3.5.99.5 | ||
| Cyp1a1 | uniprot | |
| Cyp1a2 | uniprot | |
| Cyp2a3a | uniprot | |
| Cyp2a1 | uniprot | |
| Cyp2a2 | uniprot | |
| Cyp2c12 | uniprot | |
| Cyp2d26 | uniprot | |
| Cyp2e1 | uniprot | |
| Cyp19a1 | uniprot | |
| Cyp1b1 | uniprot | |
| Cyp3a3 | ||
| Cyp2c55 | ||
| Cyp2b19 | uniprot | |
| Cyp2c38 | uniprot | |
| Cyp2f2 | uniprot | |
| Cyp4f14 | uniprot | |
| Hadhsc | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh2 | uniprot | |
| Aldh1a7 | uniprot | |
| Aldh9a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh1a7 | uniprot | |
| Aldh2 | uniprot | |
| Aldh9a1 | uniprot | |
| 4.1.1.- | ||
| Mdm2 | uniprot | |
| Mdm2 | uniprot | |
| Ube3a | uniprot | |
| Ube3a | uniprot | |
| Rnf25 | uniprot | |
| Rnf25 | uniprot | |
| Asmt | chemical | |
| Gcdh | uniprot | |
| Nicotinate and nicotinamide metabolism | ||
| PhenylAla, Tyr and Trp biosynthesis | ||
| Glycolysis / Gluconeogenesis | ||
| Benzoate degradation via hydroxylation | ||
| Benzoate degradation via hydroxylation | ||
| 6-Hydroxykynurenate | chemical | |
| 4,6-Dihydroxyquinoline | hmdbid:HMDB04077 | |
| 4-(2-Amino-5-hydroxyphenyl) | chemical | |
| 5-Hydroxykynurenamine | CHEBI:28715 | |
| 5-Hydroxykynurenine | CHEBI:2076 | |
| 5-Hydroxy-N-formylkynurenine | CHEBI:2065 | |
| N-Acetylisatin | CHEBI:16050 | |
| N-Acetylindoxyl | CHEBI:15363 | |
| Indoxyl | hmdbid:HMDB04094 | |
| 2,3-Dihydroxyindole | CHEBI:17828 | |
| 2-Oxoglutarate | hmdbid:HMDB00208 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| 5-(2’-Carboxyethyl)-4,6-dihydroxypicolinate | chemical | |
| 5-(2’-Formylethyl)-4,6-dihydroxypicolinate | chemical | |
| 5-(3’-Carboxy-3’-oxopropyl) | chemical | |
| 5-(3’-Carboxy-3’-oxopropenyl)-4,6-dihydroxypicolin | chemical | |
| 7,8-Dihydroxykynurenate | CHEBI:17508 | |
| 7,8-Dihydro-7,8-dihydroxykynurenate | CHEBI:17109 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Kynurenate | hmdbid:HMDB00715 | |
| 4-(2-Aminophenyl)-2,4-dioxobutanoate | hmdbid:HMDB00978 | |
| L-Kynurenine | hmdbid:HMDB00183 | |
| Formylkynurenine | hmdbid:HMDB01200 | |
| Indole | hmdbid:HMDB00738 | |
| 2-Formylaminobenzaldehyde | CHEBI:18033 | |
| 3-Indoleglycolaldehyde | CHEBI:15976 | |
| Indole-3-acetamide | CHEBI:16031 | |
| 5-Hydroxyindolepyruvate | CHEBI:27597 | |
| 5-Hydroxy | chemical | |
| L-Tryptophan | hmdbid:HMDB00929 | |
| C00332 | ||
| C01144 | ||
| C00877 | ||
| C00527 | ||
| 2-Oxoadipate | hmdbid:HMDB00225 | |
| 2-Aminomuconate | hmdbid:HMDB01241 | |
| 2-Aminomuconate | hmdbid:HMDB01241 | |
| Quinolinate | hmdbid:HMDB00232 | |
| 2-Amino-3-carboxymuconate | chemical | |
| 3-Hydroxyanthranilate | hmdbid:HMDB01476 | |
| Xanthurenic | chemical | |
| 4-(2-Amino-3-hydroxyphenyl) | chemical | |
| 4,8-Dihydroxyquinoline | CHEBI:28883 | |
| 3-Hydroxykynurenamine | CHEBI:27421 | |
| 3-Hydroxy- | chemical | |
| Isophenoxazine | CHEBI:17293 | |
| 2-Aminophenol | CHEBI:18112 | |
| Cinnavalininate | chemical | |
| L-Tryptophanyl-tRNA | chemical | |
| 3-(2-Aminoethyl) | chemical | |
| 5-Hydroxyindoleacetaldehyde | hmdbid:HMDB04073 | |
| 5-Hydroxyindoleacetate | hmdbid:HMDB00763 | |
| 5-Methoxytryptamine | hmdbid:HMDB04095 | |
| Formyl-5-hydroxykynurenamine | CHEBI:28736 | |
| N-Acetylserotonin | hmdbid:HMDB01238 | |
| Melatonin | hmdbid:HMDB01389 | |
| 6-Hydroxymelatonin | hmdbid:HMDB04081 | |
| Formyl-N-acetyl-5- | chemical | |
| Indolepyruvate | CHEBI:17640 | |
| Indolelactate | hmdbid:HMDB00671 | |
| 3-Methylindolepyruvate | CHEBI:28549 | |
| 6-Hydroxyindolelactate | CHEBI:27524 | |
| Indole-3-acetate | hmdbid:HMDB00197 | |
| Indole-3-acetaldehyde | hmdbid:HMDB01190 | |
| Tryptamine | hmdbid:HMDB00303 | |
| 5-Methoxyindoleacetate | hmdbid:HMDB04096 | |
| 5-Hydroxyindoleacetylglycine | CHEBI:27631 | |
| Indole-3-ethanol | hmdbid:HMDB03447 | |
| 3-Methyldioxyindole | hmdbid:HMDB04186 | |
| 2-Formamino | chemical | |
| Indole-3-acetaldoxime | CHEBI:28311 | |
| Glucobrassicin | CHEBI:29028 | |
| 3-Methoxyanthranilate | CHEBI:20109 | |
| 8-Methoxykynurenate | chemical | |
| Anthranilate | hmdbid:HMDB01123 | |
| Anthranilate | hmdbid:HMDB01123 | |
| 3-Indoleacetonitrile | CHEBI:17566 | |
| Formylanthranilate | hmdbid:HMDB04089 | |
| N-Methylserotonin | hmdbid:HMDB04369 | |
| N-Methyltryptamine | hmdbid:HMDB04370 | |
| (Z)-5-Oxohex-2-enedioate | chemical | |
| methoxykynurenamine | chemical | |
| -1H-indol-5-ol | chemical | |
| -L-tryptophan | chemical | |
| -2,4-dioxobutanoate | chemical | |
| benzoylacetate | chemical | |
| -2,4-dioxobutanoate | chemical | |
| -4,6-dihydroxypicolinate | chemical | |
| L-kynurenine | hmdbid:HMDB00183 |
| Acadl | uniprot | ||
| Hadha | uniprot | ||
| Hadhb | uniprot | ||
| Dci | uniprot | ||
| Acadl | uniprot | ||
| Hadha | uniprot | ||
| Hadhb | uniprot | ||
| Acadm | uniprot | ||
| Decr1 | uniprot | ||
| Dci | uniprot | ||
| Linoleoyl-CoA | hmdbid:HMDB01064 | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot | |
| cis,cis-3,6-Dodecadienoyl-CoA | CHEBI:28002 | ||
| trans,cis-Lauro-2,6-dienoyl-CoA | CHEBI:28387 | ||
| 4-cis-dexeboyl-CoA | chemical | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot | |
| 2-trans-4-cis-decadienoyl-CoA | CHEBI:29119 | ||
| 3-trans-decenoyl-CoA | CHEBI:29126 | ||
| trans-dec-2-enoyl-CoA | CHEBI:10723 | ||
| See Beta Oxidation 2 MAPP |
| Cps1 | uniprot |
| Glud1 | uniprot |
| Nags | uniprot |
| Pycs | uniprot |
| 2.7.2.8 | |
| 2.6.1.11 | |
| 1.2.1.38 | |
| Pycs | uniprot |
| 2.3.1.35 | |
| Otc | uniprot |
| Ass1 | uniprot |
| Oat | |
| Pycr1 | uniprot |
| Arg1 | uniprot |
| Odc1 | uniprot |
| Srm | uniprot |
| Sms | uniprot |
| Asl | uniprot |
| 3.5.1.5 | |
| 1.2.1.46 | |
| 1.5.99.1 | |
| Gatm | uniprot |
| 6.3.4.6 | |
| 3.5.1.54 | |
| 3.5.1.59 | |
| 3.5.2.14 | |
| 3.5.4.21 | |
| 3.5.3.3 | |
| Gamt | uniprot |
| 3.5.2.10 | |
| 2.7.3.1 | |
| Ckm | uniprot |
| 2.6.1.69 | |
| 3.5.1.16 | |
| Acy1 | chemical |
| Arg2 | uniprot |
| Ckb | uniprot |
| Pycrl | chemical |
| Sms | uniprot |
| Glutamate metabolism | |
| Ala and aspartate metabolism | |
| Pyrimidine metabolism | |
| Pro metabolism | |
| Nitrogen metabolism | |
| Amino acid metabolism | |
| D-Arg and D-ornithine metabolism | |
| Citrate cycle (TCA cycle) | |
| Arginine metabolism | |
| Purine metabolism | |
| NH3 | CHEBI:16134 |
| Carbamoyl | CHEBI:33100 |
| L-Glutamate | hmdbid:HMDB00148 |
| N-Acetyl-glutamate | hmdbid:HMDB01138 |
| L-Glutamyl | chemical |
| N-Acetyl-L-glutamate | hmdbid:HMDB01138 |
| N2-Acetyl-L-ornithine | CHEBI:16543 |
| N-Acetyl-L-glutamate | hmdbid:HMDB01138 |
| L-Aspartate | hmdbid:HMDB00191 |
| L-Citrulline | hmdbid:HMDB00904 |
| L-Ornithine | hmdbid:HMDB00214 |
| (S)-1-Pyrroline-5-carboxylate | hmdbid:HMDB01301 |
| L-Glutamate- | chemical |
| L-Proline | hmdbid:HMDB00162 |
| C03406 | |
| Spermine | hmdbid:HMDB01256 |
| Putrescine | hmdbid:HMDB01414 |
| Spermidine | hmdbid:HMDB01257 |
| Arginine | hmdbid:HMDB00517 |
| Fumarate | hmdbid:HMDB00134 |
| Urea | hmdbid:HMDB00294 |
| Formate | hmdbid:HMDB00142 |
| Formaldehyde | hmdbid:HMDB01426 |
| Urea-1-carboxylate | CHEBI:15832 |
| CO2 | CHEBI:16526 |
| Sarcosine | hmdbid:HMDB00271 |
| N-Methylhydantoin | CHEBI:16354 |
| N-Carbamoylsarcosine | CHEBI:15737 |
| Creatine | hmdbid:HMDB00064 |
| Creatinine | hmdbid:HMDB00562 |
| Guanidinoacetate | hmdbid:HMDB00128 |
| creatine-P | hmdbid:HMDB01511 |
| Phosphoguanidinoacetate | hmdbid:HMDB03705 |
| 5-semialdehyde | chemical |
| Wnt3a | uniprot |
| Wnt1 | uniprot |
| Wnt2 | uniprot |
| Lrp6 | uniprot |
| Wnt4 | uniprot |
| Sfrp1 | uniprot |
| Lrp5 | uniprot |
| Axin1 | uniprot |
| Gsk3b | uniprot |
| Lrp6 | uniprot |
| Fzd8 | uniprot |
| Dkk1 | uniprot |
| Dvl1 | uniprot |
| Ror2 | uniprot |
| Fzd5 | uniprot |
| Wnt7a | uniprot |
| Fzd2 | uniprot |
| Lrp1 | uniprot |
| Wnt5a | uniprot |
| Arrb2 | uniprot |
| Prkca | uniprot |
| Prkcb1 | uniprot |
| PRKCG | uniprot |
| Fzd7 | uniprot |
| Magi3 | chemical |
| Fzd4 | uniprot |
| Ltap | uniprot |
| Mapk8 | uniprot |
| Map3k7 | uniprot |
| HIPK2 | uniprot |
| Nlk | uniprot |
| Myb | uniprot |
| Fzd1 | uniprot |
| Cxxc4 | |
| Csnk1d | uniprot |
| Frat1 | uniprot |
| Tcfe2a | uniprot |
| Tcf4 | uniprot |
| Pias4 | uniprot |
| Sumo1 | uniprot |
| Dvl2 | uniprot |
| Rhoa | uniprot |
| Daam1 | uniprot |
| Csnk1e | uniprot |
| Nkd1 | |
| Brd7 | uniprot |
| Dab2 | uniprot |
| Ctnnb1 | uniprot |
| Ep300 | |
| Fhl2 | uniprot |
| Csnk2a1 | uniprot |
| Csnk2a2 | uniprot |
| Csnk2b | uniprot |
| Apc | uniprot |
| Csnk1a1 | uniprot |
| Arrb1 | uniprot |
| Ctnnbip1 | uniprot |
| Cdc25c | uniprot |
| Cdc2a | uniprot |
| Ppp2ca | uniprot |
| Dvl3 | uniprot |
| Mtap1b | uniprot |
| Nr5a1 | uniprot |
| Ctbp1 | uniprot |
| Ctbp2 | uniprot |
| Pax2 | uniprot |
| Mapk8ip1 | uniprot |
| Tbp | uniprot |
| Axin2 | uniprot |
| Sox1 | uniprot |
| Sall1 | uniprot |
| Akt1 | uniprot |
| Apc | uniprot |
| Bcl9 | uniprot |
| Pin1 | uniprot |
| Camk2a | uniprot |
| Camk2b | uniprot |
| Camk2g | uniprot |
| Camk2d | uniprot |
| Jup | uniprot |
| Rac1 | uniprot |
| Smad3 | uniprot |
| Fzd6 | uniprot |
| Ctnnb1 | uniprot |
| Sfrp2 | uniprot |
| Axin1 | uniprot |
| Btrc | chemical |
| Tcfap2a | uniprot |
| Arrb2 | uniprot |
| Runx2 | uniprot |
| Mark2 | uniprot |
| Cul1 | uniprot |
| Skp1a | uniprot |
| Smad4 | uniprot |
| Tax1bp3 | uniprot |
| Cdh1 | uniprot |
| Ruvbl1 | uniprot |
| Frat2 | uniprot |
| Dlgh4 | uniprot |
| Dlgh2 | uniprot |
| Dlgh1 | uniprot |
| Ctnnb1 | uniprot |
| Gsk3b | uniprot |
| Dvl1 | uniprot |
| Apc | uniprot |
| Lef1 | uniprot |
| Lef1 | uniprot |
| Apc | uniprot |
| Map3k7 | uniprot |
| Apc | uniprot |
| Cdc2a | uniprot |
| LOC665283 | |
| Senp2 | uniprot |
| Csnk2a1 | uniprot |
| Csnk2a2 | uniprot |
| Dvl2 | uniprot |
| Dvl1 | uniprot |
| Btrc | chemical |
| Ccnd1 | uniprot |
| Crybb2 | uniprot |
| Jun | uniprot |
| Mapk9 | uniprot |
| Fzd4 | uniprot |
| Fzd1 | uniprot |
| Ankrd6 | |
| Axin1 | uniprot |
| Sox9 | uniprot |
| Wnt1 | uniprot |
| Wnt2 | uniprot |
| Wnt1 | uniprot |
| Wnt3a | uniprot |
| Mapk3 | uniprot |
| Mapk1 | uniprot |
| Raf1 | uniprot |
| Wnt4 | uniprot |
| Akt1 | uniprot |
| Fzd1 | uniprot |
| Fzd1 | uniprot |
| Fzd9 | uniprot |
| Wnt1 | uniprot |
| Wnt1 | uniprot |
| Wnt3 | uniprot |
| Molecular Association | |
| Translocation | |
| Phosphorylation | chemical |
| Autophosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Activation | chemical |
| Inhibition | chemical |
| Acetylation | chemical |
| Ubiquitination | |
| Dephosphorylation | chemical |
| Plasma membrane | |
| PM | |
| Cytoplasm | |
| CY | |
| MT | |
| Nucleus | CHEBI:33252 |
| CY->NU | |
| CY->NU | |
| NU->CY | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| D | |
| PM->CY | |
| D | |
| D | |
| D | |
| CY->PM | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme Complex | |
| (Protein-protein interaction) | |
| Reaction through unknowm mechanisms/molecules | |
| D | |
| Accession Number: NetPath_8; cellmap:8 | |
| Demethylation | chemical |
| Methylation | chemical |
| Palmitoylation | chemical |
| Glycosylation | |
| Deacetylation | chemical |
| Golgi apparatus | |
| Endoplasmic reticulum | |
| Complex formation | |
| Deubiquitination | |
| Control | |
| Recruitment | |
| Proteolytic cleavage | |
| Extracellular | |
| Mitochondrion | |
| Endosome | |
| EN | |
| EC | |
| NU | |
| ER | |
| GO | |
| D | |
| D | |
| D | |
| D |
| Wnt1 | uniprot | |
| Wnt2 | uniprot | |
| Wnt2b | uniprot | |
| Wnt3 | uniprot | |
| Wnt3a | uniprot | |
| Wnt4 | uniprot | |
| Wnt5a | uniprot | |
| Wnt5b | uniprot | |
| Wnt6 | uniprot | |
| Wnt7a | uniprot | |
| Wnt7b | uniprot | |
| Wnt10a | uniprot | |
| Wnt10b | uniprot | |
| Wnt11 | uniprot | |
| Wnt9b | uniprot | |
| Wnt16 | uniprot | |
| Ldlr | uniprot | |
| Lrp1 | uniprot | |
| Fzd1 | uniprot | |
| Fzd2 | uniprot | |
| Fzd3 | uniprot | |
| Fzd4 | uniprot | |
| Fzd5 | uniprot | |
| Fzd6 | uniprot | |
| Fzd7 | uniprot | |
| Fzd8 | uniprot | |
| Fzd9 | uniprot | |
| Prkca | uniprot | |
| Prkcb1 | uniprot | |
| Prkcc | uniprot | |
| Prkcd | uniprot | |
| Prkce | uniprot | |
| Prkch | uniprot | |
| Prkcm | uniprot | |
| Prkcq | uniprot | |
| Prkcz | uniprot | |
| Dvl1 | uniprot | |
| Dvl2 | uniprot | |
| Dvl3 | uniprot | |
| Ppp2r5e | uniprot | |
| Ppp2r5c | uniprot | |
| Csnk1e | uniprot | |
| Axin1 | uniprot | |
| Frat1 | uniprot | |
| Gsk3b | uniprot | |
| Apc | uniprot | |
| Catnb | uniprot | |
| Rhoa | uniprot | |
| Racgap1 | uniprot | |
| Mapk9 | uniprot | |
| Mapk10 | uniprot | |
| Fbxw2 | uniprot | |
| Pafah1b1 | uniprot | |
| Tcf1 | uniprot | |
| Myc | uniprot | |
| Ccnd1 | uniprot | |
| Ccnd2 | uniprot | |
| Ccnd3 | uniprot | |
| Fosl1 | uniprot | |
| Jun | uniprot | |
| Plau | uniprot | |
| Prkci | uniprot | |
| Apoptosis | ||
| Cytoskeleton | ||
| Phosphorylated | chemical | |
| B | ||
| -Catenin | chemical | |
| P | ||
| Nucleus | CHEBI:33252 | |
| Transcriptional Activation | ||
| -Catenin | chemical | |
| B | ||
| Recruitment to Unknown | ||
| Ubiquitin Conjugating Enzyme | enzyme | |
| Ubiquitin Tagged | ||
| Frizzled Ligands | ||
| 26S Proteasome Degradation |
| Agt | uniprot |
| Ren1 | uniprot |
| Ace | |
| Agtr2 | uniprot |
| Kng1 | uniprot |
| Ace | |
| Nos3 | uniprot |
| Aldosterone | hmdbid:HMDB00037 |
| Bdkrb2 | uniprot |
| Agtr1 | uniprot |
| Angiotensin I | uniprot |
| Angiotensin II | uniprot |
| ACE Inhibitor | CHEBI:35457 |
| Bradykinin | uniprot |
| Cell Membrane |
| Pdha1 | uniprot | |
| Pdha2 | uniprot | |
| Pemt | uniprot | |
| Ahsg | uniprot | |
| Pcyt1a | uniprot | |
| Ache | ||
| Chat | ||
| Phosphatidylethanolamine | chemical | |
| Phosphatidylcholine | hmdbid:HMDB02357 | |
| Glycerophosphocholine | hmdbid:HMDB00086 | |
| Choline | hmdbid:HMDB00097 | |
| Acetyl CoA | hmdbid:HMDB01206 | uniprot |
| Pyruvate from Glycolysis | ||
| Acetate | hmdbid:HMDB00042 | |
| Choline | hmdbid:HMDB00097 | |
| Phosphorylcholine | hmdbid:HMDB01565 | |
| Cytidine Diphosphate Choline | hmdbid:HMDB01413 | |
| Acetylcholine | hmdbid:HMDB00895 | |
| *Cytosol* | chemical | |
| *Synaptic Cleft* |
| Igf1 | uniprot |
| Ptgis | uniprot |
| Ppard | uniprot |
| Creb1 | uniprot |
| Mixl1 | |
| Id3 | uniprot |
| Wnt10b | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Dlk1 | uniprot |
| Nr3c1 | uniprot |
| Ddit3 | uniprot |
| Lif | uniprot |
| Cebpb | uniprot |
| Cyp26a1 | uniprot |
| Cyp26b1 | uniprot |
| Rxra | uniprot |
| Rara | uniprot |
| Nr1h3 | uniprot |
| Lpl | uniprot |
| Srebf1 | uniprot |
| RGD:619831 | |
| Gata3 | uniprot |
| Gata2 | uniprot |
| Pparg | uniprot |
| Mef2d | uniprot |
| Agrp | uniprot |
| Tnf | uniprot |
| LOC292656 | |
| Tgfb1 | uniprot |
| Serpine1 | uniprot |
| Slc2a4 | uniprot |
| Scd1 | uniprot |
| Twist1 | uniprot |
| Lep | uniprot |
| Retn | uniprot |
| Adn | uniprot |
| Fabp4 | uniprot |
| Rb1 | uniprot |
| Rbl2 | uniprot |
| Acdc | uniprot |
| ADRP | uniprot |
| Agt | uniprot |
| Nsg1 | uniprot |
| E2f1 | uniprot |
| Sp1 | uniprot |
| Hmga1 | uniprot |
| Plin | uniprot |
| Il6 | uniprot |
| Gadd45a | uniprot |
| Gadd45b | uniprot |
| Cebpa | uniprot |
| RGD:620739 | |
| Bmp2 | uniprot |
| Bmp3 | uniprot |
| Bmp4 | uniprot |
| E2f4 | |
| Ndn | uniprot |
| Foxo1a | uniprot |
| Klf5 | uniprot |
| Ppargc1a | uniprot |
| Ncoa1 | uniprot |
| Ncoa2 | uniprot |
| Ppara | uniprot |
| Stat3 | uniprot |
| Stat2 | uniprot |
| Stat1 | uniprot |
| Stat6 | uniprot |
| Socs1 | uniprot |
| Socs3 | uniprot |
| RGD:1303100 | |
| Lifr | uniprot |
| Il6st | uniprot |
| Mbnl1 | uniprot |
| Osm | uniprot |
| Catnb | uniprot |
| Ucp1 | uniprot |
| RGD:628850 | |
| Wnt1 | uniprot |
| Madh3 | uniprot |
| Fzd1 | uniprot |
| Dvl1 | uniprot |
| Tcf1 | uniprot |
| Rxrg | uniprot |
| Frzb | uniprot |
| Ins1 | uniprot |
| Ins2 | uniprot |
| Pbef1 | uniprot |
| Trib3 | uniprot |
| Gata4 | uniprot |
| Nr2f1 | uniprot |
| Nrip1 | uniprot |
| Rora | uniprot |
| Prlr | uniprot |
| LOC362972 | |
| Cugbp1 | uniprot |
| Hif1a | uniprot |
| Copeb | uniprot |
| Klf7 | uniprot |
| Sfrp4 | uniprot |
| Ncor1 | uniprot |
| Ncor2 | uniprot |
| Ahr | uniprot |
| Klf15 | uniprot |
| Egr2 | uniprot |
| Ebf1 | uniprot |
| Epas1 | uniprot |
| RGD1309529 | |
| MGC116096 | |
| Gdf10 | uniprot |
| Irs1 | uniprot |
| Irs2 | uniprot |
| Irs3 | chemical |
| IRS-4 | |
| Lmna | uniprot |
| Agpat2 | uniprot |
| Zmpste24 | uniprot |
| Lpin1 | uniprot |
| Lpin2 | uniprot |
| Lpin3 | uniprot |
| Lipe | uniprot |
| Pck1 | uniprot |
| Pck2 | uniprot |
| Gh1 | uniprot |
| Rbl1 | uniprot |
| Mef2a | uniprot |
| LOC498607 | |
| LOC499495 | |
| Cebpd | uniprot |
| Foxc2 | uniprot |
| Spock1 | uniprot |
| Bscl2 | uniprot |
| Inhibitors of Preadipocyte to Adipocyte Transition | |
| Transcription Factors/Modulators | |
| Growth Factors/Hormones | |
| Fully Differentiated Adipocyte Markers | |
| Miscellaneous | |
| Preadipocyte | |
| Differentiated adipocyte | |
| Adipocyte Secretory Products | |
| Possible Lipodystrophy Genes | |
| Insulin Action Genes |
| Pc | ||
| 2.3.1.7 | ||
| 2.6.1.18 | ||
| Abat | uniprot | |
| 6.3.2.11 | ||
| 3.4.13.3 | ||
| 4.1.1.11 | ||
| 4.1.1.12 | ||
| Gad2 | uniprot | |
| 2.6.1.12 | ||
| Dars | uniprot | |
| Gpt1 | uniprot | |
| Agxt | uniprot | |
| 6.1.1.7 | ||
| 5.1.1.1 | ||
| 6.3.4.4 | ||
| Ass | ||
| 3.5.1.1 | ||
| 3.5.1.38 | ||
| 6.3.1.1 | ||
| 6.3.5.4 | ||
| 4.3.1.1 | ||
| Asl | uniprot | |
| 4.3.2.2 | ||
| 2.6.1.14 | ||
| 3.5.1.3 | ||
| 1.4.3.2 | ||
| 1.4.3.16 | ||
| 1.2.1.18 | ||
| 2.1.3.2 | ||
| Got2 | uniprot | |
| 6.3.5.6 | ||
| Dars | uniprot | |
| 6.1.1.22 | ||
| 1.4.3.1 | ||
| 1.4.3.15 | ||
| 3.5.1.7 | ||
| 5.1.1.13 | ||
| Aspa | uniprot | |
| Gad1 | uniprot | |
| Got1 | uniprot | |
| Glycolysis / Gluconeogenesis | ||
| Pyrimidine metabolism | ||
| Pantothenate and CoA biosynthesis | ||
| Fatty acid metabolism | ||
| Nicotinate and nicotinamide metabolism | ||
| Reductive carboxylate | chemical | |
| Citrate cycle (TCA cycle) | ||
| Reductive carboxylate cycle (CO2 fixation) | ||
| His metabolism | ||
| Nicotinate and nicotinamide metabolism | ||
| Gly, Ser and Thr metabolism | ||
| Lys biosynthesis | ||
| Urea cycle and metabolism of amino groups | ||
| Arg and Pro metabolism | ||
| beta-Ala metabolism | ||
| Selenoamino acid metabolism | ||
| Cyanoamino acid metabolism | ||
| D-Ala metabolism | ||
| Pyruvate | hmdbid:HMDB00243 | |
| O-Acetylcarnitine | hmdbid:HMDB00201 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Carnosine | hmdbid:HMDB00033 | |
| Malonate semialdehyde | hmdbid:HMDB03015 | |
| L-Alanyl-tRNA | CHEBI:17732 | |
| Protein | CHEBI:16541 | |
| D-Alanine | CHEBI:15570 | |
| L-Aspartyl-tRNA(Asp) | CHEBI:29158 | |
| N-Carbamoyl-L-aspartate | CHEBI:15859 | |
| L-Aspartate | hmdbid:HMDB00191 | |
| L-Argininosuccinate | hmdbid:HMDB00052 | |
| Adenylosuccinate | hmdbid:HMDB00536 | |
| L-Asparagine | hmdbid:HMDB00168 | |
| Citrate | hmdbid:HMDB00094 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| 2-Oxosuccinamate | CHEBI:16327 | |
| 2-Oxoglutarate | hmdbid:HMDB00208 | |
| Succinate | hmdbid:HMDB00254 | |
| Fumarate | hmdbid:HMDB00134 | |
| Malate | hmdbid:HMDB03256 | |
| L-Aspartyl- | chemical | |
| L-Asparaginyl-tRNA(Asn) | CHEBI:29265 | |
| D-Aspartate | CHEBI:29994 | |
| N-Acetyl-L-aspartate | CHEBI:16953 | |
| cycle (CO2 fixation) | ||
| tRNA(Asn) | CHEBI:29172 | |
| b-Alanine | hmdbid:HMDB00056 | |
| L-Alanine | hmdbid:HMDB00161 |
| Rhoa | uniprot |
| Rtkn | uniprot |
| Itgb4 | uniprot |
| Fyn | uniprot |
| Clca3 | |
| Ptk2 | uniprot |
| Itga6 | uniprot |
| Rpsa | uniprot |
| Vim | uniprot |
| Clca2 | |
| Grb2 | uniprot |
| DST | uniprot |
| ERBIN | uniprot |
| Erbb2 | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Pik3r3 | uniprot |
| PIK3CA | uniprot |
| Pik3cb | uniprot |
| Pik3cg | uniprot |
| Pik3cd | uniprot |
| Col17a1 | uniprot |
| Shc1 | uniprot |
| Mst1r | uniprot |
| Sfn | uniprot |
| Lama1 | uniprot |
| Lamb1 | uniprot |
| Lamc1 | uniprot |
| Lama5 | uniprot |
| Lamb2 | uniprot |
| Lama2 | uniprot |
| Lamc1 | uniprot |
| Lamb1 | uniprot |
| Lama5 | uniprot |
| Lamc1 | uniprot |
| Lamc1 | uniprot |
| Lamb1 | uniprot |
| Lama2 | uniprot |
| LOC307582 | |
| Lamb3 | uniprot |
| Lamc2 | uniprot |
| Pak1 | uniprot |
| Rac1 | uniprot |
| Plec1 | uniprot |
| Cd151 | uniprot |
| Irs2 | uniprot |
| Irs1 | uniprot |
| Egfr | uniprot |
| Ar | |
| Trp73 | |
| Ywhab | uniprot |
| Ywhae | uniprot |
| Ywhah | uniprot |
| Ywhaq | uniprot |
| Ywhaz | uniprot |
| Yes1 | uniprot |
| Dsp | |
| Met | |
| Eif4ebp1 | uniprot |
| Eif4e | uniprot |
| Itgb4bp | uniprot |
| Lamc1 | uniprot |
| Lamb2 | uniprot |
| Ntn1 | uniprot |
| Akt1 | uniprot |
| Casp3 | uniprot |
| Bad | |
| Prkca | uniprot |
| Frap1 | uniprot |
| Prkcd | uniprot |
| Mmp7 | uniprot |
| Src | uniprot |
| Rhoa | uniprot |
| Smad2 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| Smad3 | uniprot |
| Itgb4bp | uniprot |
| Cdkn1a | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Itgb4 | uniprot |
| Itga6 | uniprot |
| Abl1 | uniprot |
| Laminin 1 | |
| Laminin 2 | |
| Laminin 11 | |
| Laminin 4 | |
| Laminin 5 | |
| Laminin 10 | |
| CY->PM | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| Molecular Association | |
| Deacetylation | chemical |
| Autophosphorylation | chemical |
| D | |
| Translocation | |
| Plasma membrane | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Inhibition | chemical |
| Ligand | |
| Receptor | |
| Gene Symbol | |
| Molecule in the pathway | |
| Activation | chemical |
| Acetylation | chemical |
| Accession Number: NetPath_1; cellmap:1 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| NU | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Phosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| D | |
| D | |
| D | |
| D | |
| D |
| Ar | ||
| HSPA1A | uniprot | |
| STUB1 | uniprot | |
| Cdc37 | uniprot | |
| Cdc25b | uniprot | |
| RAS | uniprot | |
| Raf1 | uniprot | |
| Map2k1 | uniprot | |
| Ar | ||
| Ar | ||
| Ar | ||
| Cdk9 | uniprot | |
| Ctnnb1 | uniprot | |
| Cav | uniprot | |
| Crebbp | uniprot | |
| Hdac1 | uniprot | |
| Svil | uniprot | |
| Cdk7 | uniprot | |
| Ccnh | uniprot | |
| Gtf2h1 | uniprot | |
| Ctdp1 | uniprot | |
| Gtf2f1 | uniprot | |
| Gtf2f2 | uniprot | |
| Ncoa2 | uniprot | |
| Ncoa1 | uniprot | |
| Psmc3ip | ||
| Nr2c2 | uniprot | |
| Ncoa3 | uniprot | |
| Fhl2 | uniprot | |
| Flna | uniprot | |
| Flna | uniprot | |
| Aes | uniprot | |
| Bag1 | uniprot | |
| Brca1 | uniprot | |
| Ccne1 | uniprot | |
| Ccnd1 | uniprot | |
| Jun | uniprot | |
| Calr | uniprot | |
| Cox5b | uniprot | |
| Runx2 | uniprot | |
| Runx1 | uniprot | |
| Ar | ||
| Slc25a4 | uniprot | |
| Atf2 | uniprot | |
| Tmf1 | ||
| Ncoa4 | ||
| Tgfb1i1 | ||
| RNF14 | uniprot | |
| Ran | ||
| Rad54l2 | ||
| Miz1 | uniprot | |
| Uxt | uniprot | |
| Egfr | uniprot | |
| Ube3a | uniprot | |
| Esr1 | uniprot | |
| Pa2g4 | uniprot | |
| Etv5 | uniprot | |
| Mmp1a | uniprot | |
| GAPDH | enzyme | uniprot |
| Nr3c1 | uniprot | |
| Src | uniprot | |
| Mapk1 | uniprot | |
| Il6st | uniprot | |
| Myst2 | uniprot | |
| Nsd1 | uniprot | |
| Pou2f1 | uniprot | |
| Pou2f2 | uniprot | |
| Akt1 | uniprot | |
| Mdm2 | uniprot | |
| Plagl1 | ||
| RAC3 | uniprot | |
| Rb1 | uniprot | |
| Rb1 | uniprot | |
| Rela | uniprot | |
| RANBP9 | uniprot | |
| Nrip1 | uniprot | |
| Rnf4 | uniprot | |
| ZNF278 | uniprot | |
| Pxn | uniprot | |
| SPDEF | uniprot | |
| Hrmt1l2 | uniprot | |
| Hrmt1l2 | uniprot | |
| Pnrc1 | uniprot | |
| Pias4 | uniprot | |
| Pias1 | uniprot | |
| Pias3 | uniprot | |
| Stat3 | uniprot | |
| Pnrc1 | uniprot | |
| Smad3 | uniprot | |
| Smad4 | uniprot | |
| SRY | uniprot | |
| Nr0b2 | uniprot | |
| Sp1 | uniprot | |
| Ncor2 | uniprot | |
| Tgif | uniprot | |
| Ube2i | uniprot | |
| Sin3a | uniprot | |
| Rchy1 | uniprot | |
| Rchy1 | uniprot | |
| Hipk3 | uniprot | |
| Pak6 | ||
| PCAF | uniprot | |
| Akt1 | uniprot | |
| APPL | uniprot | |
| Htatip | uniprot | |
| Ep300 | ||
| Senp1 | uniprot | |
| Cdc2a | uniprot | |
| Mapk1 | uniprot | |
| Jun | uniprot | |
| Nr3c1 | uniprot | |
| Il6 | uniprot | |
| Pten | uniprot | |
| Esr2 | uniprot | |
| Nr0b1 | uniprot | |
| Igf1 | uniprot | |
| GHBP | uniprot | |
| Ghr | uniprot | |
| Tp53 | uniprot | |
| Casp1 | uniprot | |
| Casp3 | uniprot | |
| Casp7 | uniprot | |
| Casp8 | uniprot | |
| Hmgb2 | uniprot | |
| HMGB1 | uniprot | |
| Ywhah | uniprot | |
| Nr5a1 | uniprot | |
| Esr1 | uniprot | |
| Androgen (T/DHT) | ||
| P | ||
| P | ||
| P | ||
| P | ||
| Molecular association | ||
| Proteolytic Cleavage | ||
| DeSumoylation | ||
| Phosphorylation | chemical | |
| Activation | chemical | |
| Ubiquitination | ||
| Translocation | ||
| Inhibition | chemical | |
| Enzyme complex | ||
| Androgen Independent | ||
| P | ||
| CY | ||
| NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| Gene Symbol | ||
| Molecule in the pathway | ||
| Cytoplasm | ||
| Nucleus | CHEBI:33252 | |
| D | ||
| D | ||
| D | ||
| D | ||
| (Protein-protein interaction) | ||
| Reactions through unknown mechanisms/molecules | ||
| D | ||
| Receptor | ||
| Ligand | ||
| Proteins in a complex interaction | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Sumoylation | chemical | |
| Deubiquitination | ||
| Recruitment | ||
| Control | ||
| EC | ||
| EN | ||
| Extracellular | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi appparatus | ||
| MT | ||
| Mitochondrion | ||
| PM | ||
| Plasma membrane | ||
| Androgen Independent | ||
| Accession Number: NetPath_2; cellmap:2 |
| Tradd | chemical |
| Tnfsf10 | uniprot |
| Tnfrsf1a | uniprot |
| Tnf | uniprot |
| Tnfrsf1b | uniprot |
| Trap1 | uniprot |
| Traf2 | uniprot |
| Map3k1 | uniprot |
| Map2k4 | uniprot |
| Mapk10 | uniprot |
| Fadd | uniprot |
| Ripk1 | uniprot |
| Birc3 | uniprot |
| Birc3 | uniprot |
| Birc4 | uniprot |
| Casp6 | uniprot |
| Casp7 | uniprot |
| Casp3 | uniprot |
| Casp2 | uniprot |
| Bcl2 | uniprot |
| RGD:735223 | |
| Bcl2l1 | uniprot |
| Gzmb | uniprot |
| Prf1 | uniprot |
| Tnfsf6 | uniprot |
| Bak1 | uniprot |
| Bid | |
| Bax | uniprot |
| Myc | uniprot |
| Tp53 | uniprot |
| Mdm2 | uniprot |
| RGD:727889 | |
| Nfkb1 | uniprot |
| Apaf1 | uniprot |
| Casp9 | |
| Cycs | uniprot |
| Cyct | uniprot |
| Nfkbia | uniprot |
| Jun | uniprot |
| Bcl2l11 | uniprot |
| Bid3 | uniprot |
| Bnip3l | uniprot |
| Casp10 | |
| Dffb | uniprot |
| Dffa | uniprot |
| Hells | uniprot |
| Bad | |
| Casp1 | uniprot |
| Casp4 | uniprot |
| Casp11 | uniprot |
| Casp8 | uniprot |
| Traf3 | uniprot |
| Tnfrsf25 | |
| Lta | uniprot |
| Tnfrsf10b | uniprot |
| Tnfrsf21 | uniprot |
| Ikbkb | uniprot |
| Chuk | uniprot |
| Nfkbib | uniprot |
| Nfkbie | uniprot |
| Nfkbia | uniprot |
| Nfkbib | uniprot |
| Nfkbie | uniprot |
| Nfkb1 | uniprot |
| RGD:727889 | |
| Birc5 | uniprot |
| Trp73 | |
| Trp63 | uniprot |
| Irf1 | uniprot |
| Irf2 | uniprot |
| Irf3 | uniprot |
| Irf4 | uniprot |
| Irf5 | uniprot |
| Irf6 | uniprot |
| Irf7 | uniprot |
| RGD:2323 | |
| Cflar | uniprot |
| Tnfrsf1a | uniprot |
| Cradd | uniprot |
| Tradd | chemical |
| Ripk1 | uniprot |
| RGD:619831 | |
| Diablo | uniprot |
| Bcl2l2 | uniprot |
| Mcl1 | uniprot |
| Bok | uniprot |
| Bbc3 | uniprot |
| Pmaip1 | chemical |
| Bad | |
| Akt1 | uniprot |
| Pik3r1 | uniprot |
| Igf1r | uniprot |
| Igf2 | uniprot |
| Igf1 | uniprot |
| Apoptosis | |
| Activator of Cell Death | |
| Inhibitor of Cell Death | |
| Fas Ligand | uniprot |
| DNA Fragmentation | |
| e | |
| e | |
| Mitochondrion | |
| p | |
| p | |
| degredation | |
| b | |
| Casp | uniprot |
| b | |
| p53 Related | |
| Interferon regulatory factors | |
| b |
| Cd79b | uniprot | |
| Blk | uniprot | |
| Fyn | uniprot | |
| Lyn | ||
| Syk | uniprot | |
| Blnk | uniprot | |
| Map4k1 | uniprot | |
| Cd5 | uniprot | |
| Ptk2 | uniprot | |
| Ptpn6 | uniprot | |
| Hcls1 | uniprot | |
| WAS | ||
| Actr2 | uniprot | |
| Actr3 | uniprot | |
| Arpc1b | uniprot | |
| Arpc2 | uniprot | |
| Arpc3 | uniprot | |
| Arpc4 | uniprot | |
| Arpc5 | uniprot | |
| Hcls1 | uniprot | |
| Grb2 | uniprot | |
| Grb2 | uniprot | |
| Sos1 | uniprot | |
| Nck1 | ||
| Vav1 | uniprot | |
| Plcg1 | uniprot | |
| Cr2 | uniprot | |
| Cd19 | uniprot | |
| Cd81 | uniprot | |
| Plcg2 | uniprot | |
| Pik3r1 | uniprot | |
| Pik3r2 | uniprot | |
| Pik3ap1 | ||
| Mapk1 | uniprot | |
| Elk1 | uniprot | |
| Btk | uniprot | |
| RGD1561386 | ||
| Shc1 | uniprot | |
| Bcar1 | uniprot | |
| Nedd9 | uniprot | |
| Ptk2b | uniprot | |
| Hck | uniprot | |
| Crkl | uniprot | |
| LOC365948 | ||
| Itpr2 | uniprot | |
| PILRB | uniprot | |
| Ptpn11 | uniprot | |
| Cd22 | uniprot | |
| Casp9 | ||
| Casp7 | uniprot | |
| Cblb | uniprot | |
| Sh3bp2 | uniprot | |
| Vav2 | uniprot | |
| Prkcm | uniprot | |
| SOS2 | uniprot | |
| Ptpn6 | uniprot | |
| Itk | uniprot | |
| Tec | uniprot | |
| Crk | uniprot | |
| Rapgef1 | chemical | |
| Lcp2 | uniprot | |
| RGD1311584 | ||
| Dok1 | uniprot | |
| Ptpn18 | uniprot | |
| PIP5K1A | uniprot | |
| Pip5k2a | uniprot | |
| Pip5k1a | uniprot | |
| Pip5k2b | uniprot | |
| Pip5k1c | uniprot | |
| Pip5k2c | ||
| Pip5k1a | uniprot | |
| Pip5k2b | uniprot | |
| Rps6ka1 | uniprot | |
| Mapk3 | uniprot | |
| Rasa1 | uniprot | |
| Rps6ka1 | uniprot | |
| Prkcd | uniprot | |
| Prkcd | uniprot | |
| Creb1 | uniprot | |
| Lat2 | uniprot | |
| Pdpk1 | uniprot | |
| Akt1 | uniprot | |
| Akt1 | uniprot | |
| Gsk3a | uniprot | |
| RAP2A | uniprot | |
| Foxo1a | uniprot | |
| Inpp5d | ||
| Dok3 | uniprot | |
| Mapk8 | uniprot | |
| Fcgr2b | uniprot | |
| Hcls1 | uniprot | |
| Rps6kb1 | uniprot | |
| Rps6 | uniprot | |
| Gab2 | uniprot | |
| Jun | uniprot | |
| Atf2 | uniprot | |
| Mapk14 | uniprot | |
| Bcl6 | uniprot | |
| Mapkapk2 | uniprot | |
| CDK2 | uniprot | |
| Rb1 | uniprot | |
| Cdk4 | uniprot | |
| Cdk6 | uniprot | |
| Ctnnb1 | uniprot | |
| Ctnnb1 | uniprot | |
| Gsk3b | uniprot | |
| Ikbkb | uniprot | |
| Chuk | uniprot | |
| Nfkbia | uniprot | |
| Rela | uniprot | |
| Rel | uniprot | |
| Rela | uniprot | |
| Rel | uniprot | |
| Prkcb1 | uniprot | |
| Cd72 | uniprot | |
| Atp2b4 | uniprot | |
| Nfatc2 | uniprot | |
| Nfatc3 | uniprot | |
| Nfatc2 | uniprot | |
| Nfatc3 | uniprot | |
| Ppp3ca | uniprot | |
| Ppp3cb | uniprot | |
| Aps | uniprot | |
| Gtf2i | uniprot | |
| RGD1564153 | ||
| PLEKHA2 | uniprot | |
| Dapp1 | uniprot | |
| PLEKHA2 | uniprot | |
| RGD1564153 | ||
| RGD1562795 | ||
| Csk | uniprot | |
| CARD11 | uniprot | |
| Bcl10 | uniprot | |
| Map3k7 | uniprot | |
| Ikbkg | uniprot | |
| Ccnd2 | uniprot | |
| Ccnd3 | uniprot | |
| Ccne1 | uniprot | |
| Ccna2 | uniprot | |
| Hnrpk | uniprot | |
| Ptprc | uniprot | |
| Ppp3r1 | uniprot | |
| NFATC1 | uniprot | |
| PRKCQ | uniprot | |
| Cdk7 | uniprot | |
| CD79A | uniprot | |
| Dapp1 | uniprot | |
| HDAC5 | uniprot | |
| Hdac7a | uniprot | |
| HDAC5 | uniprot | |
| Hdac7a | uniprot | |
| Cycs | uniprot | |
| Cycs | uniprot | |
| Raf1 | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Dusp4 | uniprot | |
| Dusp6 | uniprot | |
| Stat3 | uniprot | |
| Stat1 | uniprot | |
| Zap70_mapped | ||
| Bcl2l11 | uniprot | |
| Mapk4 | uniprot | |
| RGD1562071 | ||
| GalNAc4S6ST | enzyme | uniprot |
| Cmtm3 | uniprot | |
| Bcl2 | uniprot | |
| IGHM | uniprot | |
| Prkcb1 | uniprot | |
| Rasgrp3 | ||
| Braf | uniprot | |
| Pdk2 | uniprot | |
| Bax | uniprot | |
| Bax | uniprot | |
| Rasgrp3 | ||
| Gab1 | uniprot | |
| Pip5k1a | uniprot | |
| Pip5k2b | uniprot | |
| Shc1 | uniprot | |
| Prkce | uniprot | |
| Prkce | uniprot | |
| Gtf2i | uniprot | |
| Itpr1 | uniprot | |
| Pik3ap1 | ||
| CARD11 | uniprot | |
| Rapgef1 | chemical | |
| Crk | uniprot | |
| Btk | uniprot | |
| Blnk | uniprot | |
| Gab1 | uniprot | |
| Ptpn6 | uniprot | |
| Plcg2 | uniprot | |
| Inpp5d | ||
| Chuk | uniprot | |
| Ikbkb | uniprot | |
| Lyn | ||
| Syk | uniprot | |
| CD79A | uniprot | |
| Lyn | ||
| Syk | uniprot | |
| Lat2 | uniprot | |
| Rhoa | uniprot | |
| Gene Symbol | ||
| Pik3cg | uniprot | |
| Lck | uniprot | |
| ARP2/3 | ||
| Complex | ||
| Molecular association | ||
| Phosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Translocation | ||
| Ubiquitination | ||
| Cytoplasm | ||
| Nucleus | CHEBI:33252 | |
| Mitochondria | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->NU | ||
| CY->PM | ||
| CY->PM | ||
| CY->NU | ||
| CY->PM | ||
| CY->PM | ||
| Autophosphorylation | chemical | |
| Plasma membrane | ||
| CY->PM | ||
| PM->CY | ||
| NU->CY | ||
| NU->CY | ||
| CY->MT | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| D | ||
| Receptor | ||
| Accesion Number: NetPath_12 | ||
| MA | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| CY->NU | ||
| CY->NU | ||
| CY->PM | ||
| CY->NU | ||
| CY->PM | ||
| CY->PM | ||
| CY->PM | ||
| PM->CY | ||
| MT->CY | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| Enzyme Complex | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| D | ||
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Sumoylation | chemical | |
| Desumoylation | ||
| Deubiquitination | ||
| Activation | chemical | |
| Inhibition | chemical | |
| Recruitment | ||
| Control | ||
| PM | ||
| CY | ||
| EC | ||
| Extracellular | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi apparatus | ||
| MT | ||
| NU | ||
| Ligand | ||
| D |
| Th | |
| Ddc | uniprot |
| Dbh | uniprot |
| Pnmt | uniprot |
| Pah | uniprot |
| Ddc | uniprot |
| Aanat | uniprot |
| Hdc | uniprot |
| Ddc | uniprot |
| Gad1 | uniprot |
| Gad2 | uniprot |
| Comt | uniprot |
| Maoa | uniprot |
| Ache | |
| Maoa | uniprot |
| Tph | uniprot |
| Asmt | chemical |
| Chat | |
| Tyrosine | hmdbid:HMDB00158 |
| L-DOPA | hmdbid:HMDB00181 |
| Dopamine | hmdbid:HMDB00073 |
| Norepinephrine | hmdbid:HMDB00216 |
| Epinephrine | hmdbid:HMDB00068 |
| Phenylalanine | hmdbid:HMDB00159 |
| Tryptophan | hmdbid:HMDB00929 |
| 5-hydroxy-tryptophan | chemical |
| Serotonin | hmdbid:HMDB00259 |
| Acetylserotonin | chemical |
| Melatonin | hmdbid:HMDB01389 |
| Histidine | hmdbid:HMDB00177 |
| Histamine | hmdbid:HMDB00870 |
| Glutamate | hmdbid:HMDB03339 |
| GABA | hmdbid:HMDB00112 |
| Choline | hmdbid:HMDB00097 |
| Acetylcholine | hmdbid:HMDB00895 |
| Synthesis pathways for biogenic amines (in blue) | |
| follow solid arrows through enzymatic steps, | |
| while degradation steps follow dashed arrows. |
| RGD:727845 | ||
| Serpine1 | uniprot | |
| Serpinb2 | uniprot | |
| Plat | uniprot | |
| Plg | uniprot | |
| Plau | uniprot | |
| F2 | ||
| RGD:727845 | ||
| Fgl2 | uniprot | |
| F5 | ||
| RGD:621759 | ||
| RGD:621759 | ||
| F9 | ||
| F10 | uniprot | |
| F7 | ||
| F7 | ||
| Fga | uniprot | |
| F13a | uniprot | |
| A2AP | ||
| Factor XII | ||
| F11 | uniprot | |
| Factor X | uniprot | |
| Factor XIa | ||
| Factor VIIIa | ||
| Factor IXa | ||
| Factor Xa | ||
| Factor Va | ||
| Thrombin | enzyme | uniprot |
| Fibrin Monomer | ||
| Factor XIIIa | ||
| Fibrin Polymer | ||
| Factor VIIa | ||
| + | ||
| + | ||
| Intrinsic Pathway | ||
| Extrinsic Pathway | ||
| Tissue Factor | ||
| Plasmin | enzyme | |
| Fibrin | ||
| Fibrin Split Products | ||
| Thrombolysis | ||
| Tissue Injury | ||
| Factor XIIa |
| Gnas | uniprot | |
| Gnaq | uniprot | |
| Anxa6 | uniprot | |
| Ryr2 | ||
| Fkbp1a | uniprot | |
| Calr | uniprot | |
| Casq2 | uniprot | |
| Adcy7 | uniprot | |
| Rgs2 | uniprot | |
| Adcy4 | uniprot | |
| Ywhah | uniprot | |
| Ywhag | uniprot | |
| Ywhae | uniprot | |
| Ywhaz | uniprot | |
| Rgs19 | uniprot | |
| Prkch | uniprot | |
| Prkar2a | uniprot | |
| Adcy8 | uniprot | |
| Adcy6 | uniprot | |
| Prkce | uniprot | |
| Prkcz | uniprot | |
| Prkcd | uniprot | |
| Prkcc | uniprot | |
| Prkca | uniprot | |
| Adcy2 | uniprot | |
| Prkar1b | uniprot | |
| Rgs4 | uniprot | |
| Rgs16 | uniprot | |
| Rgs14 | uniprot | |
| Rgs11 | uniprot | |
| Rgs10 | uniprot | |
| Rgs9 | uniprot | |
| Rgs7 | uniprot | |
| Prkar2b | uniprot | |
| Rgs5 | uniprot | |
| Prkaca | uniprot | |
| Rgs3 | uniprot | |
| Rgs1 | uniprot | |
| Adcy5 | uniprot | |
| Adcy3 | uniprot | |
| Prkar1a | uniprot | |
| Rgs6 | uniprot | |
| Gng2 | uniprot | |
| Gnb5 | uniprot | |
| Gnb1 | uniprot | |
| Gprk6 | uniprot | |
| Plcb3 | uniprot | |
| Gng4 | uniprot | |
| Gprk2l | uniprot | |
| Gprk5 | uniprot | |
| Pkib | uniprot | |
| Calm2 | uniprot | |
| Pkig | uniprot | |
| Pkia | uniprot | |
| Gng3 | uniprot | |
| Gng11 | uniprot | |
| Gng5 | uniprot | |
| Gng12 | uniprot | |
| Gng8 | uniprot | |
| Gng7 | uniprot | |
| Ywhab | uniprot | |
| Plcb3 | uniprot | |
| Arrb2 | uniprot | |
| Arrb1 | uniprot | |
| Calm1 | uniprot | |
| Ryr3 | ||
| Itpr1 | uniprot | |
| Itpr2 | uniprot | |
| Itpr3 | uniprot | |
| Calm3 | uniprot | |
| Gna11 | uniprot | |
| Ryr1 | ||
| Atp2a2 | uniprot | |
| Atp2a3 | uniprot | |
| Camk2a | uniprot | |
| Camk2b | uniprot | |
| Camk2g | uniprot | |
| Camk2d | uniprot | |
| Camk1 | uniprot | |
| Camk4 | uniprot | |
| Cacnb3 | uniprot | |
| Cacnb1 | uniprot | |
| Atp2b3 | uniprot | |
| Atp2b2 | uniprot | |
| Atp2b1 | uniprot | |
| Slc8a3 | uniprot | |
| Slc8a1 | uniprot | |
| Atp1a4 | uniprot | |
| Atp1b1 | uniprot | |
| Atp1b2 | uniprot | |
| Atp1b3 | uniprot | |
| Fxyd2 | uniprot | |
| Chrm1 | uniprot | |
| Chrm2 | uniprot | |
| Chrm3 | uniprot | |
| Chrm4 | uniprot | |
| Chrm5 | uniprot | |
| Cacna1c | uniprot | |
| Cacna1d | uniprot | |
| RGD:2246 | ||
| Cacna1s | uniprot | |
| Cacna1a | uniprot | |
| Cacna1b | uniprot | |
| Adrb1 | uniprot | |
| Adrb3 | uniprot | |
| Adrb2 | uniprot | |
| Adra1a | uniprot | |
| Adra1b | uniprot | |
| Adra1d | uniprot | |
| Gja1 | uniprot | |
| Gja3 | uniprot | |
| Gja4 | uniprot | |
| Gja5 | uniprot | |
| Gja6 | uniprot | |
| RGD:628889 | ||
| Gja8 | uniprot | |
| Gja9 | uniprot | |
| Gjb1 | uniprot | |
| Gjb2 | uniprot | |
| Gjb3 | uniprot | |
| RGD:621829 | ||
| Gjb5 | uniprot | |
| Gjb6 | uniprot | |
| Kcnj3 | uniprot | |
| Kcnj5 | uniprot | |
| Kcnb1 | uniprot | |
| Gnai1 | uniprot | |
| Gnai2 | uniprot | |
| Gnai3 | uniprot | |
| Gnao | uniprot | |
| Gnaz | uniprot | |
| Ywhaq | uniprot | |
| Gnb3 | uniprot | |
| Gnb2 | uniprot | |
| Gng1 | uniprot | |
| Gng13 | uniprot | |
| Prkcb | uniprot | |
| Prkcl | ||
| Gja12 | uniprot | |
| Gja10 | uniprot | |
| Adcy1 | uniprot | |
| Adcy9 | uniprot | |
| Gnb4 | uniprot | |
| Pln | uniprot | |
| Prkacb | uniprot | |
| Prkcm | uniprot | |
| PRKCQ | uniprot | |
| Rgs17 | uniprot | |
| Rgs18 | uniprot | |
| Rgs20 | uniprot | |
| Sfn | uniprot | |
| cAMP | hmdbid:HMDB00058 | |
| Ca2+ | CHEBI:29108 | |
| Na+ | CHEBI:29101 | |
| Na+ | CHEBI:29101 | |
| P | ||
| FKBP12 | uniprot | |
| P | ||
| Ca | ||
| IP3 | ||
| DAG | uniprot | |
| PIP2 | uniprot | |
| SR | ||
| GRK | ||
| Calmodulin | uniprot | |
| PKA Inhibitors | ||
| beta Arrestin | ||
| Protein Kinase A | uniprot | |
| Signaling | ||
| PKC inhibitor Protein-1 | ||
| Adenylyl Cyclases | enzyme | uniprot |
| G | ||
| Regulators of G-protein | ||
| bg | ||
| Protein Kinase C | uniprot | |
| Protein Kinase A | uniprot | |
| Na2+ | ||
| Repolarization | ||
| Cytosolic Ca | chemical | |
| 2+ | ||
| Ca | ||
| 2+ | ||
| Calreticulin-Ca | ||
| Calsequestrin C-Ca | chemical | |
| Calsequestrin S-Ca | chemical | |
| 2+ | ||
| 2+ | ||
| 2+ | ||
| 2+ | ||
| Cytosolic Ca | chemical | |
| ATP | hmdbid:HMDB00538 | |
| ADP + Pi | ||
| Phopholamban | chemical | |
| ADP + Pi | ||
| 2+ | ||
| Cytosolic Ca | chemical | |
| Acetylcholine | hmdbid:HMDB00895 | |
| Epinephrine | hmdbid:HMDB00068 | |
| Epinephrine | hmdbid:HMDB00068 | |
| IP4 | ||
| IP3 Receptors | ||
| Ca | ||
| 2+ | ||
| 2+ | ||
| Cytosol | ||
| CaM kinase | enzyme | |
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| CaM kinase | enzyme | |
| K+ | ||
| Ca | ||
| 2+ | ||
| ATP | hmdbid:HMDB00538 | |
| Dihydropyridine-Sensitive | ||
| Membrane | ||
| Depolarization | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| Na+/Ca2+ Exchanger | ||
| Na+/K+ ATPase | ||
| ATP | hmdbid:HMDB00538 | |
| Adrenergic Receptor | ||
| a | ||
| L-Type Ca2+ Channel | ||
| M1 Muscarinic Receptor | ||
| b | ||
| Adrenergic Receptor | ||
| Cyclases | uniprot | |
| Adenylyl | chemical | |
| G | ||
| b | ||
| G | ||
| g | ||
| G | ||
| bg | ||
| IP3 Receptors | ||
| Connexin | ||
| Connexin | ||
| Gap Junctions (Connexins) | ||
| Ca | ||
| 2+ | ||
| Ca | ||
| 2+ | ||
| b | ||
| arrestin/GRK | ||
| b | ||
| arrestin/GRK | ||
| G alpha i/o/z | ||
| K+ | ||
| K+ | ||
| G | ||
| bg | ||
| G alpha i/o/z |
| Mcmd6 | uniprot | |
| WEE1 | uniprot | |
| Pttg3 | chemical | |
| Rb1 | uniprot | |
| Rb1 | uniprot | |
| Cdc25b | uniprot | |
| Elavl3 | uniprot | |
| Elavl3 | uniprot | |
| Cdk4 | uniprot | |
| Ccnh | uniprot | |
| Gsk3b | uniprot | |
| Tgfb1 | uniprot | |
| Madh3 | uniprot | |
| Madh4 | uniprot | |
| Ccnd3 | uniprot | |
| Ccnd2 | uniprot | |
| Ccne1 | uniprot | |
| Cdkn1a | uniprot | |
| Ccna2 | uniprot | |
| Pcna | uniprot | |
| Ywhag | uniprot | |
| Gadd45a | uniprot | |
| Cdc25a | uniprot | |
| Elavl3 | uniprot | |
| Ccne2 | uniprot | |
| Tp53 | uniprot | |
| Prkdc | uniprot | |
| Chek2 | uniprot | |
| Mps1 | uniprot | |
| Mad2l1 | uniprot | |
| Cdc2 | uniprot | |
| Cdkn1a | uniprot | |
| Ccnb1 | uniprot | |
| Ccnb2 | uniprot | |
| CycB3 | uniprot | |
| Cdc2a | uniprot | |
| Rb1 | uniprot | |
| Rbl1 | uniprot | |
| Cdc7 | uniprot | |
| Dbf4 | uniprot | |
| Cdc45 | uniprot | |
| Cdc6 | uniprot | |
| Cdkn1a | uniprot | |
| Myt1 | uniprot | |
| SKP2 | uniprot | |
| Cdc14a | uniprot | |
| Cdc14b | uniprot | |
| Bub2 | ||
| Men | ||
| Cdc20 | uniprot | |
| Espl1 | uniprot | |
| Smc1l1 | uniprot | |
| Mdm2 | uniprot | |
| ARF | uniprot | |
| E2f1 | uniprot | |
| Mst1 | uniprot | |
| E2f3 | uniprot | |
| E2f5 | uniprot | |
| E2f4 | ||
| Rbl1 | uniprot | |
| E2f6 | uniprot | |
| Ube2f | ||
| DP1 | uniprot | |
| Cdh1 | uniprot | |
| SKP2 | uniprot | |
| Orc1l | uniprot | |
| 14-3-3 | ||
| Plk1 | uniprot | |
| Orc6l | uniprot | |
| Orc3l | uniprot | |
| Orc5l | uniprot | |
| RGD:735212 | ||
| RGD:1303018 | ||
| Mcmd4 | uniprot | |
| Mcm5 | uniprot | |
| Mcm3 | uniprot | |
| Bub1 | uniprot | |
| Bub1b | uniprot | |
| Atm | uniprot | |
| Abl1 | uniprot | |
| Atr | uniprot | |
| Mad2l2 | uniprot | |
| Bub3 | uniprot | |
| Ep300 | ||
| Pttg1 | uniprot | |
| Pttg2 | chemical | |
| Cdc25c | uniprot | |
| Cdk6 | uniprot | |
| Mad1l1 | uniprot | |
| Orc2l | uniprot | |
| RGD:2323 | ||
| Cdkn1b | uniprot | |
| Ccna2 | uniprot | |
| RGD:619975 | ||
| RGD:619976 | ||
| Hdac3 | uniprot | |
| RGD:619979 | ||
| Hdac5 | uniprot | |
| Hdac6 | uniprot | |
| Hdac7a | uniprot | |
| HDAC8 | uniprot | |
| Mcm2 | uniprot | |
| Chek1 | uniprot | |
| MAPK | enzyme | uniprot |
| signaling | ||
| pathway | ||
| Growth Factor | ||
| withdrawal | ||
| R-point | ||
| (Start) | ||
| +p | ||
| e | ||
| e | ||
| p16,15,18,19 | ||
| p27,57 | ||
| p21 | uniprot | |
| Histone Deacetylases | uniprot | |
| +u | ||
| +u | ||
| +u | ||
| +p | ||
| e | ||
| e | ||
| e | ||
| Apoptosis | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| HDAC | ||
| E2F | ||
| DNA | CHEBI:16991 | |
| SCF | uniprot | |
| ORC | ||
| MCM | uniprot | |
| +p | ||
| DNA | CHEBI:16991 | |
| DNA biosynthesis | ||
| S-phase proteins | ||
| +p | ||
| SCF | uniprot | |
| APC/C | ||
| -p | ||
| APC/C | ||
| +u | ||
| DNA damage checkpoint | ||
| Securin | uniprot | |
| Separin | hmdbid:HMDB05005 | uniprot |
| Condensin | ||
| Transcription Factor E2F | ||
| Ubiquitin | uniprot | |
| mediated | ||
| proteolysis | chemical | |
| ORC (Origin | ||
| Recognition Complex) | ||
| MCM (Mini-Chromosome | ||
| Maintenance) complex | ||
| G1 | ||
| M | ||
| G2 | ||
| S | ||
| +p | ||
| +u | ||
| +p | ||
| -p | ||
| Growth Factor | ||
| +p | ||
| +p |
| Fdps | uniprot | |
| Idi1 | uniprot | |
| Hmgcs1 | uniprot | |
| Hmgcr | uniprot | |
| Mvk | uniprot | |
| Mvd | uniprot | |
| Fdps | uniprot | |
| Fdft1 | uniprot | |
| Dhcr7 | uniprot | |
| Lss | uniprot | |
| Sqle | uniprot | |
| Cyp51 | uniprot | |
| Sc4mol | uniprot | |
| Nsdhl | uniprot | |
| Pmvk | uniprot | |
| SC5DL | uniprot | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| HMG-CoA | hmdbid:HMDB01375 | |
| Geranyl-PP | hmdbid:HMDB01285 | |
| Squalene | hmdbid:HMDB00256 | |
| Squalene-2,3-Epoxide | hmdbid:HMDB01188 | |
| Lanosterol | hmdbid:HMDB01251 | |
| Lathosterol | hmdbid:HMDB01170 | |
| 7-dehydro Cholesterol | hmdbid:HMDB00032 | |
| Cholesterol | hmdbid:HMDB00067 | |
| Mevalonate | hmdbid:HMDB00227 | |
| Mevalonate-5-P | chemical | |
| Mevalonate-5-PP | chemical | |
| Delta-Isopentenyl-5-PP | chemical | |
| trans-trans-farnesyl-pp | ||
| DiMethylally-PP | chemical | |
| Fatty Acid Degradation |
| Myf6 | uniprot |
| Bteb1 | uniprot |
| Herpud1 | uniprot |
| Sf3a3 | uniprot |
| Cbx3 | uniprot |
| Oazin | uniprot |
| Psma4 | uniprot |
| Zfr | |
| Sumo1 | uniprot |
| Hist1h2bn | uniprot |
| Pura | uniprot |
| Cry2 | uniprot |
| Per1 | uniprot |
| Per2 | uniprot |
| Cry1 | uniprot |
| Ppp1r3c | chemical |
| Cebpb | uniprot |
| Ppp2cb | uniprot |
| NCOA4 | uniprot |
| ETV6 | uniprot |
| RGD:708372 | |
| RGD:735053 | |
| Hspa8 | uniprot |
| Dnaja1 | uniprot |
| Ucp3 | uniprot |
| Gstm5 | uniprot |
| Ugp2 | uniprot |
| Cldn5 | uniprot |
| LOC500614 | |
| Tubb3 | uniprot |
| Gfra1 | uniprot |
| Map3k7ip2 | uniprot |
| LOC499417 | |
| Gstp2 | uniprot |
| Nckap1 | uniprot |
| Vapa | uniprot |
| RGD1311800 | |
| LOC503172 | |
| Idi1 | uniprot |
| RGD:621126 | |
| LOC499022 | |
| RBPMS | uniprot |
| G0s2 | uniprot |
| Arntl | uniprot |
| Nr1d2 | uniprot |
| Clock | |
| Btg1 | uniprot |
| Eif4g2 | uniprot |
| Per1 | uniprot |
| Per2 | uniprot |
| E-Box | |
| E-Box | |
| LRE | |
| LRE | |
| Cry1 | uniprot |
| Cry2 | uniprot |
| Per | |
| Cry | |
| Metabolism | |
| Chaperone | |
| Protein Modification | |
| Transcription | |
| Cell Cycle | |
| DNA/RNA Binding | |
| Other | |
| Structural/Cytoskeleton | |
| Signaling | |
| mHrts | |
| mHrts | |
| mHrts | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrp mSCNp | |
| mHrts | |
| mSCNp | |
| mHrts | |
| mLvrs | |
| mHrts | |
| mHrts | |
| mHrts | |
| mLvrs | |
| mLvrs | |
| mLvrp | |
| mLvrp | |
| mLvrp | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrs,p SCNp | |
| mHrts | |
| mLvrs | |
| mSCNp | |
| mSCNp | |
| mLvrs,p | chemical |
| mLvrp mSCNp | |
| mLvrs | |
| mLvrs | |
| mHrts | |
| mLvrp | |
| mSCNp | |
| mHrts | |
| mHrts | |
| mLvrs,p | chemical |
| mLvrp | |
| mLvrp | |
| mHrts Lvrsp | |
| mHrts mLvrs | |
| mLvrs,p | chemical |
| mHrts mLvrs, mSCNp | |
| Nucleus | CHEBI:33252 |
| mHrts mLvrs,p mSCN | |
| mHrts mLvrs,p | |
| mHrts mLvrs | |
| mHrts mLvrp | |
| mHrts mLvrs,p mSCNp |
| C1qa | uniprot |
| C1qb | uniprot |
| C3 | |
| C9 | |
| C4a | uniprot |
| C1r | uniprot |
| C1s | uniprot |
| C2 | |
| C6 | |
| C7 | |
| Masp1 | uniprot |
| Daf1 | uniprot |
| C5 | |
| C8 | |
| C1qc | uniprot |
| antigen/antibody | |
| complex | |
| C1 complex | |
| aggregated IgG, | |
| IgM-antigen complex, | |
| polyanions, RNA, DNA | |
| lipopolysacharides | |
| Membrane | |
| attack complex | |
| Ions | CHEBI:24870 |
| H O | |
| 2 | |
| Cytoplasm | |
| Plasma | |
| Membrane | |
| Prevents Complement Attack | |
| Proteolytic Cleavage | |
| Complex | |
| Formation |
| C1qb | uniprot | |
| C1s | uniprot | |
| C2 | ||
| C3 | ||
| Hc | ||
| C6 | ||
| C9 | ||
| Masp1 | uniprot | |
| Mcp | uniprot | |
| Crry | uniprot | |
| Cfi | uniprot | |
| Masp2 | uniprot | |
| C4bp | uniprot | |
| C3ar1 | uniprot | |
| C5r1 | uniprot | |
| Adn | uniprot | |
| Cfh | uniprot | |
| F3 | ||
| F7 | ||
| F9 | ||
| RGD:727845 | ||
| RGD:621759 | ||
| F10 | uniprot | |
| F5 | ||
| F2 | ||
| Fgb | uniprot | |
| Serpind1 | uniprot | |
| Cpb2 | uniprot | |
| Tfpi | uniprot | |
| F2r | uniprot | |
| Serpina1 | uniprot | |
| Proc | uniprot | |
| Pros1 | uniprot | |
| Plat | uniprot | |
| Plau | uniprot | |
| Thbd | uniprot | |
| Plaur | uniprot | |
| Plg | uniprot | |
| Kng1 | uniprot | |
| Serpinf2 | uniprot | |
| Bdkrb1 | uniprot | |
| C7 | ||
| C8b | uniprot | |
| C1qa | uniprot | |
| C1qg | uniprot | |
| C1r | uniprot | |
| C4a | uniprot | |
| Mbl1 | uniprot | |
| Cd59 | uniprot | |
| Cr2 | uniprot | |
| Crry | uniprot | |
| Daf2 | uniprot | |
| Daf1 | uniprot | |
| F12 | uniprot | |
| F11 | uniprot | |
| F13b | uniprot | |
| H2-Bf | uniprot | |
| Klkb1 | uniprot | |
| Serpina5 | uniprot | |
| Serpinc1 | uniprot | |
| RGD:735225 | ||
| Serpine1 | uniprot | |
| A2m | uniprot | |
| membrane attack complex | ||
| Cell lysis | ||
| C3 | ||
| Convertase | ||
| C3b | ||
| Antibody/antigen | ||
| complex | ||
| C4b/2a | ||
| Muscle contraction, | ||
| Chemotaxis, | ||
| Phagocyte recruitment | ||
| Inflammation, etc. | ||
| C5a | ||
| C3a | ||
| C4a | uniprot | |
| C3b/4b, C3b, C3d | ||
| Mediators | ||
| Classical Pathway | ||
| C3b/Bb | ||
| insulin, etc. | ||
| Zymosan | ||
| Alternative Pathway | ||
| Complement Cascade | ||
| Lectin Pathway | ||
| Thrombin | enzyme | uniprot |
| Clot | ||
| fibrin degredation | ||
| Vascular injury | ||
| products | ||
| Fibrin | ||
| monomer | ||
| Cross-linked | ||
| fibrin polymer | ||
| Platelet, monocyte, | ||
| lymphocyte, | ||
| endothelial cells, | ||
| smooth muscle cells | ||
| activation, etc. | ||
| Coagulation Cascade | ||
| Extrinsic pathway | ||
| Degredation | ||
| Cell adhesion, | ||
| migration, | ||
| proliferation, etc. | ||
| Cell adhesion, | ||
| migration, | ||
| proliferation, etc. | ||
| Bradykinin | uniprot | |
| Collagen, | ||
| basement membrane, | ||
| activated platelets, etc. | ||
| Fibrinolytic system | ||
| Kinin kallikrein system |
| Cxcl1 | uniprot |
| Tnf | uniprot |
| Il1b | uniprot |
| Il1a | uniprot |
| Il6 | uniprot |
| Tnf | uniprot |
| IL1b | |
| IL1a | |
| TNF | uniprot |
| Tgfb1 | uniprot |
| Pdgfa | uniprot |
| TNF | uniprot |
| IL1a | |
| IL1b | |
| TNF | uniprot |
| IL1a | |
| IL1b | |
| IL6 | uniprot |
| IL11 | uniprot |
| RGD:628704 | |
| Csf1 | uniprot |
| Csf2 | uniprot |
| G-csf | |
| IL1b | |
| IL6 | uniprot |
| IL12 | |
| IL15 | uniprot |
| IL3 | uniprot |
| IL6 | uniprot |
| IL7 | uniprot |
| GM-csf | |
| IL3 | uniprot |
| IL4 | uniprot |
| IL10 | uniprot |
| IL13 | uniprot |
| IFNa | |
| IFNg | |
| TNF | uniprot |
| IL12 (via APC) | |
| IL15 | uniprot |
| IL2 | uniprot |
| IFNg | |
| IL15 | uniprot |
| IL3 | uniprot |
| IL4 | uniprot |
| IL10 | uniprot |
| IL4 | uniprot |
| IL10 | uniprot |
| IL4 | uniprot |
| IL6 | uniprot |
| TGFb | |
| IL2 | uniprot |
| IL4 | uniprot |
| IL13 | uniprot |
| IL5 | uniprot |
| TGFb1 | |
| IL2 | uniprot |
| IFNg | |
| IL5 | uniprot |
| IL1a | |
| IL2 | uniprot |
| TNF | uniprot |
| IFNb | |
| IFNa | |
| IL10 | uniprot |
| IL2 | uniprot |
| IL2 | uniprot |
| IL3 | uniprot |
| CD4 | uniprot |
| GRO1 | uniprot |
| Macrophage | |
| Neutrophil | |
| T-helper | |
| Hypothalamus | |
| Fibroblasts | |
| Endothelial Cells | |
| Inflammatory Response | |
| Hematopoietic Stem Cell | |
| Hematopoiesis | |
| T-helper | |
| Lymphocyte Activated | |
| Mast Cell | |
| B Cell | |
| B Cell | |
| B Cell | |
| Plasma Cell | |
| Antibodies | |
| Killer Cells (LAK) | |
| Eos | |
| Eos | |
| Eos | |
| Th | |
| Th | |
| Th | |
| Tc | |
| Tc | |
| Tc | |
| clonal expansion of T cells | |
| (fever) | |
| MHC II | |
| TCR | |
| NK cell | |
| B Cell |
| Notch1 | uniprot |
| Notch2 | uniprot |
| Notch3 | uniprot |
| Notch4 | uniprot |
| Dll1 | uniprot |
| Dll4 | uniprot |
| Jag1 | uniprot |
| Jag2 | uniprot |
| Psen1 | uniprot |
| Psen2 | uniprot |
| Aph1a | uniprot |
| Aph1b | uniprot |
| Psenen | uniprot |
| Ncstn | uniprot |
| Adam10 | uniprot |
| Dll1 | uniprot |
| Dll1 | uniprot |
| Adam17 | uniprot |
| Notch1 | uniprot |
| Notch1 | uniprot |
| Notch2 | uniprot |
| Notch4 | uniprot |
| Gsk3b | uniprot |
| Notch2 | uniprot |
| Gsk3b | uniprot |
| Numb | |
| Itch | uniprot |
| App | |
| Numbl | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Akt1 | uniprot |
| Pcsk3 | uniprot |
| Cntn1 | uniprot |
| Nov | |
| DTX1 | uniprot |
| Ascl1 | uniprot |
| Ep300 | |
| Tp53 | uniprot |
| Lfng | uniprot |
| Mfng | uniprot |
| Pofut1 | uniprot |
| Skp1a | uniprot |
| FBXW7 | uniprot |
| Hey1 | uniprot |
| MAML2 | uniprot |
| Glrp1 | |
| Maml1 | uniprot |
| RGD1561926 | |
| Ncor2 | uniprot |
| NCOR1 | uniprot |
| Hdac1 | uniprot |
| RGD1309199 | |
| SAP30 | uniprot |
| Hdac2 | uniprot |
| Sin3a | uniprot |
| Hes1 | uniprot |
| Stat3 | uniprot |
| Jak2 | uniprot |
| NCOR1 | uniprot |
| Ncor2 | uniprot |
| Rela | uniprot |
| Nfkbia | uniprot |
| Hey2 | uniprot |
| Tle1 | uniprot |
| Rela | uniprot |
| Smad3 | uniprot |
| Smad4 | uniprot |
| Yy1 | uniprot |
| CDK2 | uniprot |
| Lef1 | uniprot |
| RGD1563119 | |
| Skp1a | uniprot |
| Cul1 | uniprot |
| RGD1562456 | |
| Rbx1 | uniprot |
| Tcfe2a | uniprot |
| Mapk3 | uniprot |
| Mapk1 | uniprot |
| Wdr12 | uniprot |
| PCAF | uniprot |
| Fhl1 | uniprot |
| Ring1 | uniprot |
| Hivep3 | |
| SPEN | uniprot |
| Ep300 | |
| Smad1 | uniprot |
| Hes6 | uniprot |
| GATA1 | uniprot |
| MAGEA1 | uniprot |
| Cntfr | uniprot |
| Cntf | uniprot |
| Hes5 | uniprot |
| Stat3 | uniprot |
| Jun | uniprot |
| RBPSUH | uniprot |
| Notch3 | uniprot |
| DTX1 | uniprot |
| RGD1562456 | |
| Egf | uniprot |
| Egfr | uniprot |
| Jag1 | uniprot |
| Jag1 | uniprot |
| Jag2 | uniprot |
| Notch1 | uniprot |
| Dll4 | uniprot |
| Jag2 | uniprot |
| Notch3 | uniprot |
| Notch1 | uniprot |
| Notch1 | uniprot |
| Notch2 | uniprot |
| Lck | uniprot |
| Molecular association | |
| Phosphorylation | chemical |
| Proteolytic Cleavage | |
| Ubiquitination | |
| Translocation | |
| Gamma secretase complex | |
| Intracellular Domain | |
| -- ICD | |
| ICD | |
| ICD | |
| ICD | |
| ICD | |
| ICD | |
| Glycosylation | |
| PM | |
| GO->PM | |
| CY->NU | |
| NU->CY | |
| PM->NU | |
| PM->NU | |
| PM->NU | |
| NU->CY | |
| NU->CY | |
| D | |
| D | |
| D | |
| GO->PM | |
| PM->CY | |
| PM->NU | |
| ICD | |
| (Protein-protein interaction) | |
| Activation | chemical |
| Inhibition | chemical |
| D | |
| Reactioin through unknown mechanisms/molecules | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| CY | |
| Plasma membrane | |
| Cytoplasm | |
| GO | |
| Golgi apparatus | |
| Nucleus | CHEBI:33252 |
| NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| Accession Number: NetPath_3; cellmap:3 | |
| Enzyme complex | |
| D | |
| D | |
| CY->NU | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| MT | |
| Mitochondrion |
| Rpa2 | uniprot | |
| Rpa3 | uniprot | |
| RPA4 | uniprot | |
| POLA | uniprot | |
| RGD:621380 | ||
| PRIM2A | uniprot | |
| Pole2 | uniprot | |
| Pole | ||
| Orc3l | uniprot | |
| Orc2l | uniprot | |
| Orc5l | uniprot | |
| RGD:735212 | ||
| Orc1l | uniprot | |
| Orc6l | uniprot | |
| Gmnn | uniprot | |
| CDT1 | uniprot | |
| Mcm6 | uniprot | |
| Mcm5 | uniprot | |
| Mcm4 | uniprot | |
| LOC367976 | ||
| Mcm2 | uniprot | |
| RGD:1303018 | ||
| Mcm10 | uniprot | |
| Cdk2 | uniprot | |
| Pola2 | uniprot | |
| Rfc5 | uniprot | |
| Rfc4 | uniprot | |
| Rfc3 | uniprot | |
| Rfc2 | uniprot | |
| Recc1 | uniprot | |
| Pcna | uniprot | |
| ASK | uniprot | |
| Cdc7 | uniprot | |
| Rpa1 | uniprot | |
| LOC287961 | ||
| Pold2 | uniprot | |
| Pold3 | uniprot | |
| Pold4 | uniprot | |
| Pold1 | uniprot | |
| Cdc6 | uniprot | |
| Ubc | uniprot | |
| Mcm3 | uniprot | |
| Origin | ||
| Orc3 | uniprot | |
| Orc2 | uniprot | |
| Orc5 | uniprot | |
| Orc2 | uniprot | |
| Orc3 | uniprot | |
| Orc5 | uniprot | |
| Orc4 | uniprot | |
| Orc1 | uniprot | |
| Orc3 | uniprot | |
| Orc5 | uniprot | |
| Orc4 | uniprot | |
| Orc2 | uniprot | |
| Cdc6 | uniprot | |
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Cdt1 | uniprot | |
| Geminin | uniprot | |
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Mcm10 | uniprot | |
| Cdt1 | uniprot | |
| Phosphorylation of Mcm 2-7 complex | ||
| DNA polymerase alpha: primase: origin complex | ||
| DNA polymerase alpha: primase: origin complex | ||
| CTP | hmdbid:HMDB00082 | uniprot |
| GTP | hmdbid:HMDB01273 | |
| UTP | hmdbid:HMDB00285 | |
| ATP | hmdbid:HMDB00538 | |
| RNA Primer | ||
| dCTP | hmdbid:HMDB00998 | |
| dGTP | hmdbid:HMDB01440 | |
| dUTP | hmdbid:HMDB01191 | |
| dATP | hmdbid:HMDB01532 | |
| Phosphorylated Orc1 | ||
| Ubiquitin | uniprot | |
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| Phosphorylated Cdc6 | ||
| Ubiquitinated Orc1 | ||
| Ubiquitinated Cdc6 | ||
| Degraded by proteasome in cytosol | ||
| Degraded by proteasome in cytosol | ||
| RNA primer-DNA primer | ||
| RNA primer-DNA primer | ||
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| p49 | uniprot | |
| p58 | uniprot | |
| p70 | uniprot | |
| p180 | uniprot | |
| RFC36 | uniprot | |
| RFC37 | uniprot | |
| RFC38 | uniprot | |
| RFC40 | uniprot | |
| RFC140 | uniprot | |
| Mcm 4,6,7 trimer forms and associates | ||
| Ubiquitin | uniprot | |
| with the replication fork | ||
| Orc2 | uniprot | |
| Orc3 | uniprot | |
| RFC Heteropentamer:RNA primer-DNA primer | ||
| ATP | hmdbid:HMDB00538 | |
| PCNA homotrimer | ||
| RFC Heteropentamer:RNA primer-DNA primer: | ||
| RNA primer-DNA primer:origin duplex:PCNA | ||
| Primase | ||
| DNA Polymerase | uniprot | |
| a | ||
| Pre-replicative complex | ||
| 2. Activation of the pre-replicative complex | ||
| 3. DNA replication initiation | ||
| Pre-replicative complex | ||
| 1. Assembly of the pre-replicative complex | ||
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| Orc Complex | ||
| Cdc6 | uniprot | |
| Cdt1 | uniprot | |
| Mcm2 | uniprot | |
| Mcm3 | uniprot | |
| Mcm4 | uniprot | |
| Mcm6 | uniprot | |
| Mcm7 | uniprot | |
| 4. Switching of origins to post-replicative state | ||
| 5. Leading/lagging strand synthesis | ||
| Orc complex | ||
| Processive complex | ||
| Orc complex | ||
| Orc complex | ||
| Orc complex | ||
| Mcm5 | uniprot | |
| Mcm5 | uniprot |
| Egf | uniprot |
| Raf1 | uniprot |
| Hras | uniprot |
| Nras | uniprot |
| Kras | uniprot |
| Shoc2 | uniprot |
| Pik3r1 | uniprot |
| Map3k2 | uniprot |
| Grb14 | uniprot |
| Grb2 | uniprot |
| RGD1566234 | |
| Map3k3 | uniprot |
| Sos1 | uniprot |
| Grb7 | uniprot |
| Pik3r2 | uniprot |
| Shc1 | uniprot |
| Pik3r3 | uniprot |
| PIK3CA | uniprot |
| Pik3cb | uniprot |
| Pik3cd | uniprot |
| Pik3cg | uniprot |
| Gab1 | uniprot |
| Gab2 | uniprot |
| Jak1 | uniprot |
| Stat1 | uniprot |
| Jak2 | uniprot |
| Stat3 | uniprot |
| Stat5a | uniprot |
| Stat2 | uniprot |
| Stat5b | uniprot |
| Map2k1 | uniprot |
| Prkca | uniprot |
| MAP3K1 | uniprot |
| Prkcz | uniprot |
| Prkcm | uniprot |
| Prkci | uniprot |
| Prkcb1 | uniprot |
| Prkcc | uniprot |
| Map2k2 | uniprot |
| Map2k3 | uniprot |
| Map2k5 | uniprot |
| Map3k4 | uniprot |
| Vav1 | uniprot |
| RGD1565941 | |
| Vav2 | uniprot |
| MAPK7 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Elk4 | uniprot |
| Elk1 | uniprot |
| Mapk8 | uniprot |
| Map2k7 | |
| Ptprr | uniprot |
| Gja1 | uniprot |
| Ywhab | uniprot |
| WNK1 | uniprot |
| Egfr | uniprot |
| Krt2-7 | |
| Krt2-8 | uniprot |
| Ka17 | |
| Krt1-18 | uniprot |
| HIST3H3 | uniprot |
| SNRPD2 | uniprot |
| EPPK1 | uniprot |
| Plec1 | uniprot |
| Ptpn12 | uniprot |
| Stat3 | uniprot |
| Plscr1 | uniprot |
| Errfi1 | uniprot |
| Dok2 | uniprot |
| Pitpna | uniprot |
| Cblc | uniprot |
| Cblb | uniprot |
| Pld2 | uniprot |
| Pld1 | uniprot |
| Prkca | uniprot |
| Eps15 | uniprot |
| Eps8 | uniprot |
| Hdh | uniprot |
| Pik3c2b | |
| Sh3bgrl | uniprot |
| Csk | uniprot |
| RGD1561642 | |
| Ralbp1 | uniprot |
| Ralb | uniprot |
| Reps1 | uniprot |
| Tnk2 | uniprot |
| Abi1 | uniprot |
| SOS2 | uniprot |
| Dnm1 | uniprot |
| Sh3gl3 | uniprot |
| Cdc42 | uniprot |
| Spry2 | uniprot |
| Jund | uniprot |
| Fos | uniprot |
| Cebpa | uniprot |
| Myc | uniprot |
| Cebpb | uniprot |
| Pebp1 | uniprot |
| Tcfcp2l2 | uniprot |
| Sin3a | uniprot |
| Tgif | uniprot |
| Hdac1 | uniprot |
| Sh3kbp1 | uniprot |
| Sh3gl2 | uniprot |
| Jun | uniprot |
| Sp1 | uniprot |
| Akt1 | uniprot |
| PTPN5 | uniprot |
| Snca | uniprot |
| Rps6ka1 | uniprot |
| RGD1563860 | |
| Rps6ka2 | uniprot |
| Ap2a1 | uniprot |
| WASL | uniprot |
| Ceacam1 | uniprot |
| Eef1a1 | uniprot |
| APPL | uniprot |
| RGD1563028 | |
| Mta2 | uniprot |
| LOC361120 | |
| Epn1 | uniprot |
| Hip1 | uniprot |
| Rfxank | uniprot |
| Mapk14 | uniprot |
| Tnip1 | uniprot |
| Egfr | uniprot |
| Egfr | uniprot |
| Rbbp7 | uniprot |
| Ddef1 | uniprot |
| Stxbp1 | uniprot |
| Ctnnd1 | uniprot |
| Pkn2 | uniprot |
| Pak1 | uniprot |
| Sh2d3c | uniprot |
| Bcar1 | uniprot |
| Casp9 | |
| Rps6ka5 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| Smad2 | uniprot |
| Smad3 | uniprot |
| Atf1 | uniprot |
| Creb1 | uniprot |
| Foxo1a | uniprot |
| Pxn | uniprot |
| Elf3 | |
| Hat1 | uniprot |
| Camk2a | uniprot |
| Itch | uniprot |
| Araf | uniprot |
| Mcf2 | chemical |
| Elf3 | |
| RGD1563860 | |
| Map3k2 | uniprot |
| Foxo1a | uniprot |
| Eps15 | uniprot |
| Eef1a1 | uniprot |
| Stat1 | uniprot |
| Stat3 | uniprot |
| Stat2 | uniprot |
| Stat5a | uniprot |
| RGD1562173 | |
| Plcg1 | uniprot |
| Spry2 | uniprot |
| Plcg2 | uniprot |
| Plcg2 | uniprot |
| Ptpn6 | uniprot |
| Raf1 | uniprot |
| Gab1 | uniprot |
| Shc1 | uniprot |
| Pld1 | uniprot |
| Bcar1 | uniprot |
| Sh2d3c | uniprot |
| Stxbp1 | uniprot |
| APPL | uniprot |
| APPL | uniprot |
| RGD1563028 | |
| Stat1 | uniprot |
| Src | uniprot |
| RGD1561386 | |
| Crk | uniprot |
| Crkl | uniprot |
| RGD1565358 | |
| Rac1 | uniprot |
| Ptk2b | uniprot |
| Cav | uniprot |
| Cav2 | uniprot |
| Nck1 | |
| Nck2 | uniprot |
| Plcg1 | uniprot |
| Git1 | uniprot |
| Rgs16 | uniprot |
| Socs1 | uniprot |
| Socs3 | uniprot |
| Inppl1 | |
| Rab5a | uniprot |
| Usp6nl | uniprot |
| Arf4 | uniprot |
| RGD1562173 | |
| Ripk1 | uniprot |
| Map3k14 | uniprot |
| Ralgds | uniprot |
| Rasa1 | uniprot |
| Ptk6 | uniprot |
| PRKAR1A | uniprot |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Mapk1 | uniprot |
| Map2k1 | uniprot |
| Dusp1 | uniprot |
| Dusp1 | uniprot |
| Arf4 | uniprot |
| Arf4 | uniprot |
| Egf | uniprot |
| Egf | uniprot |
| Sh3gl2 | uniprot |
| Egfr | uniprot |
| Molecular association | |
| Translocation | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Enzyme complex | |
| Plasma membrane | |
| Extracellular | |
| Gene Symbol | |
| PM | |
| CY | |
| PM | |
| NU | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| CY | |
| NU | |
| NU | |
| CY | |
| MA | |
| MA | |
| MA | |
| MA | |
| CY | |
| NU | |
| NU | |
| CY | |
| CY | |
| NU | |
| NU | |
| CY | |
| CY | |
| PM | |
| NU | |
| CY | |
| MA | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| PM | |
| CY | |
| CY | |
| NU | |
| PM | |
| CY | |
| PM | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| PM | |
| CY | |
| PM | |
| NU | |
| PM | |
| CY | |
| PM | |
| EN | |
| PM | |
| EN | |
| PM | |
| CY | |
| NU | |
| EC | |
| Proteins in a complex interaction | |
| (Protein-protein interaction) | |
| Autodephosphorylation | chemical |
| Acetylation | chemical |
| Accession Number : NetPath_4; cellmap:4 | |
| MA | |
| MA | |
| D | |
| D | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| MA | |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Desumoylation |
| Ptgis | uniprot | |
| Tbxas1 | uniprot | |
| Ptgds | uniprot | |
| Ptges | uniprot | |
| PGE2 9-ketoreduc | ||
| Ptgs1 | uniprot | |
| Ptgs2 | uniprot | |
| Alox5ap | uniprot | |
| Alox5 | uniprot | |
| Dpep1 | uniprot | |
| Tgm2 | uniprot | |
| Ltc4s | uniprot | |
| Peroxidase? | ||
| Alox5 | uniprot | |
| Alox5ap | uniprot | |
| Peroxidase? | ||
| Alox15 | uniprot | |
| Alox15 | uniprot | |
| Pla2g2c | uniprot | |
| Pla2g2c | uniprot | |
| Pla2g2a | uniprot | |
| Alox15b | uniprot | |
| Peroxidase? | ||
| Pla2g6 | uniprot | |
| Lta4h | uniprot | |
| Alox12e | uniprot | |
| Ltb4 | ||
| PGD2 11-ketoreduc | ||
| Cell Membrane | ||
| Arachadonic Acid | chemical | |
| PGH2 | hmdbid:HMDB01381 | |
| 5-HPETE | ||
| 12-HPETE | ||
| 15-HPETE | ||
| 15-HETE | ||
| 12-HETE | CHEBI:19138 | |
| LTC4 | hmdbid:HMDB01198 | |
| LTD4 | CHEBI:28666 | |
| LTE4 | hmdbid:HMDB02200 | |
| PGI2 | hmdbid:HMDB01335 | uniprot |
| PGF2-alpha | chemical | |
| PGD2 | hmdbid:HMDB01403 | |
| TXA2 | hmdbid:HMDB01452 | |
| Lipox = Lipoxygenase | ||
| ETE = Eicosatetraenoic Acid | ||
| HP = Hydroperoxy | ||
| H = Hydroxy | ||
| diH = Dihydroxy | ||
| PG = Prostaglandin | ||
| LT = Leukotriene | ||
| TX = Thromboxane | ||
| 6-KetoPGF2-alpha | chemical | |
| 5-HETE | CHEBI:28209 | |
| LTA4 | hmdbid:HMDB01337 | uniprot |
| LTB4 | uniprot | |
| TXB2 | CHEBI:28728 | |
| TXA3 | ||
| PGE2 | hmdbid:HMDB01220 |
| Mtnd1 | uniprot |
| Mtnd4 | uniprot |
| Rpl36 | uniprot |
| Mtnd6 | uniprot |
| Mlrq | |
| Ndufs6 | uniprot |
| Rabep2 | uniprot |
| Cycs | uniprot |
| Cyct | uniprot |
| Cox4i1 | uniprot |
| Cox5a | uniprot |
| Cox5b | uniprot |
| Cox6a2 | uniprot |
| Cox6a1 | uniprot |
| Cox6c | uniprot |
| Cox7a3 | uniprot |
| Cox8h | uniprot |
| Cox8a | uniprot |
| Cox17 | uniprot |
| Surf1 | uniprot |
| Atp5a1 | uniprot |
| Atp5b | uniprot |
| Atp5c1 | uniprot |
| Atp5d | uniprot |
| Atp5e | uniprot |
| Atp5j | uniprot |
| Atp5o | uniprot |
| Sbk | uniprot |
| Atp5f1 | uniprot |
| Atp5g1 | uniprot |
| Atp5g2 | uniprot |
| Atp5g3 | uniprot |
| Ucp1 | uniprot |
| Ucp2 | uniprot |
| Ucp3 | uniprot |
| Slc25a4 | uniprot |
| Slc25a5 | uniprot |
| Mtnd4l | uniprot |
| Mtnd3 | uniprot |
| Mtnd2 | uniprot |
| Sdha | uniprot |
| Sdhb | uniprot |
| LOC308770 | |
| Slc25a14 | uniprot |
| Slc25a6 | |
| Mtco1 | uniprot |
| Mtco2 | uniprot |
| Lat | uniprot |
| Cox7c | uniprot |
| Atp5i | uniprot |
| Ndufa5 | uniprot |
| Ndufv2 | uniprot |
| Sdhc | uniprot |
| Sdhd | uniprot |
| RGD:1303314 | |
| Uqcrc2 | uniprot |
| RGD:628838 | |
| Cox6b | uniprot |
| RGD:727789 | |
| C subunit | |
| F1 Complex | |
| Stalk | |
| F0 Complex | |
| Uncoupling Protein | |
| Complex I | uniprot |
| Complex IV | |
| Complex III | |
| Complex II | |
| Oxidoreductase | enzyme |
| NADH-Ubiquinone | chemical |
| Succinate-Ubiquinone | chemical |
| Oxidoreductase | enzyme |
| Ubiquinol-Cytochrome C | chemical |
| Reductase | enzyme |
| Cytochrome C | |
| Oxidase | |
| ATP Synthase (Complex V) | |
| Adenine Nucleotide | chemical |
| Translocator | |
| Ubiquinone | hmdbid:HMDB02012 |
| Daxx | uniprot |
| Daxx | uniprot |
| Tnfsf6 | uniprot |
| RGD:619831 | |
| Hspb1 | uniprot |
| Tnf | uniprot |
| Il1a | uniprot |
| Mapkapk2 | uniprot |
| Mapkapk3 | uniprot |
| Cycs | uniprot |
| Bcl2 | uniprot |
| Casp9 | |
| Apaf1 | uniprot |
| Apaf1 | uniprot |
| Casp3 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| Hspb1 | uniprot |
| actin | uniprot |
| Fadd | uniprot |
| Faf1 | uniprot |
| Faf1 | uniprot |
| LOC498331 | |
| Casp8 | uniprot |
| Casp8 | uniprot |
| Cflar | uniprot |
| LOC500417 | |
| Caspase 7 | |
| Caspase 3 | |
| Adprt | uniprot |
| Pak1 | uniprot |
| Pak2 | uniprot |
| Arhgdib | uniprot |
| Spna1 | uniprot |
| Dffa | uniprot |
| Dffb | uniprot |
| Dffb | uniprot |
| DNA-PK | |
| Caspase 6 | |
| Lmna | uniprot |
| Lmnb1 | uniprot |
| LOC299625 | |
| Rb1 | uniprot |
| Map3k1 | uniprot |
| Map2k4 | uniprot |
| Mapk8 | uniprot |
| Map3k7 | uniprot |
| Jun | uniprot |
| casp10 | |
| Stress | |
| Mitochondria Pathway | |
| Apoptosome | |
| Proteasome | enzyme |
| NFK-B | |
| Pathway | |
| ROS | CHEBI:26523 |
| Cell Survival | |
| Necrosis | |
| P | |
| Apoptosis | |
| FAS Pathway | |
| P | |
| P | |
| 3x-P | |
| 3x-P | |
| 3x-P | |
| DNA presentation | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| P | |
| Ceramide | hmdbid:HMDB04957 |
| Extracellular | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Stress Induction of HSP regulation | |
| Cut | |
| Inhibition | chemical |
| Activate | |
| Self-activation | |
| Glutathione | hmdbid:HMDB00125 |
| Lipc | uniprot | |
| Lipe | uniprot | |
| Lipf | uniprot | |
| Pnpla2 | chemical | |
| Gyk | uniprot | |
| Gk2 | ||
| Gpd2 | uniprot | |
| Tpi1 | uniprot | |
| Lpl | uniprot | |
| Acas2 | uniprot | |
| Acsl1 | uniprot | |
| Acsl3 | uniprot | |
| Acsl4 | uniprot | |
| Acsl5 | uniprot | |
| Acsl6 | uniprot | |
| Crat | uniprot | |
| Cpt1a | uniprot | |
| Chkb | uniprot | |
| Cpt2 | uniprot | |
| Slc25a20 | uniprot | |
| Cpt1b | uniprot | |
| Acadvl | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Hadhb | uniprot | |
| Hadha | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Hadha | uniprot | |
| Hadha | uniprot | |
| Hadha | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Hadhb | uniprot | |
| Hadhb | uniprot | |
| Hadhb | uniprot | |
| Acadl | uniprot | |
| Acadl | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Triacylglycerol | chemical | |
| Glycerol | hmdbid:HMDB00131 | |
| Dihydroxyacetone Phosphate | hmdbid:HMDB01473 | |
| Fatty Acid | CHEBI:35366 | |
| Acyl-CoA | CHEBI:17984 | |
| Palmitoyl-CoA | hmdbid:HMDB01338 | |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 | |
| L-Glycerol-3-Phosphate | chemical | |
| See Glycolysis MAPP | ||
| Trans-Hexadecanoyl-CoA | chemical | |
| (S)-3-Hydroxyhexadecanoyl-CoA | chemical | |
| 3-Oxopalmitoyl-CoA | hmdbid:HMDB06402 | |
| Myristoyl-CoA | CHEBI:15532 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Trans-Tetradex-2-enoyl-CoA | chemical | |
| (S)-3-Hydroxytetradecanoyl-CoA | chemical | |
| Dxotetradecanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Lauroyl-CoA | hmdbid:HMDB03571 | |
| 2-trans-dodecenoyl-CoA | CHEBI:15471 | |
| (S)-3-Hydroxydodexanonyl-CoA | chemical | |
| 3-Oxododexanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Decanoyl-CoA | CHEBI:28493 | |
| See Beta Oxidation 2 MAPP | ||
| Lipases | enzyme | uniprot |
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP |
| Acadm | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Acadm | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Acads | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Decanoyl-CoA | CHEBI:28493 | |
| See Beta Oxidation 1 MAPP | ||
| Trans-Dec-2-enoyl-CoA | CHEBI:10723 | |
| (S)-3-Hydroxydecanoyl-CoA | chemical | |
| 3-Oxocanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Octaoyl-CoA | chemical | |
| Trans-Oct-2-enoyl-CoA | CHEBI:27537 | |
| (S)-3-Hydroxyoctanoyl-CoA | chemical | |
| 3-Oxo-octanoyl-CoA | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Hexanoyl-CoA | hmdbid:HMDB02845 | |
| See Beta Oxidation Unsaturated MAPP | ||
| Trans-Hex-2-enoyl-CoA | CHEBI:28706 | |
| (S)-Hydrocyhexanoyl | chemical | |
| 3-Oxohexanoyl-CoA | CHEBI:27648 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Butanoyl-CoA | hmdbid:HMDB01088 | |
| See Beta Oxidation 3 MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP | ||
| See TCA Cycle MAPP |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Acat1 | uniprot | |
| Hadha | uniprot | |
| Hadhb | uniprot | |
| Acads | uniprot | |
| Gcdh | uniprot | |
| Dld | uniprot | |
| Butanoyl-CoA | hmdbid:HMDB01088 | |
| See Beta Oxidation 2 | ||
| Cronoyl-CoA | chemical | |
| (S)-3-Hydroxybutanoyl-CoA | hmdbid:HMDB01166 | |
| Acetoacetyl-CoA | hmdbid:HMDB01484 | |
| Glutaryl-CoA | hmdbid:HMDB01339 | |
| Glutarate | hmdbid:HMDB00661 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| See TCA Cycle |
| Lpl | uniprot |
| Gyk | uniprot |
| Gk2 | |
| Tpi1 | uniprot |
| Acsl1 | uniprot |
| Acsl3 | uniprot |
| Acsl4 | uniprot |
| Acsl6 | uniprot |
| Crat | uniprot |
| Cpt1a | uniprot |
| Chkb | uniprot |
| Cpt2 | uniprot |
| Slc25a20 | uniprot |
| Cpt1b | uniprot |
| Acadvl | uniprot |
| Hadha | uniprot |
| Hadhb | uniprot |
| Echs1 | uniprot |
| Hadhsc | uniprot |
| Hadhsc | uniprot |
| Hadhb | uniprot |
| Acads | uniprot |
| Echs1 | uniprot |
| Acads | uniprot |
| Hadhsc | uniprot |
| Acat1 | uniprot |
| Hadha | uniprot |
| Hadhb | uniprot |
| Dld | uniprot |
| Gcdh | uniprot |
| Lipc | uniprot |
| Lipe | uniprot |
| Lipf | uniprot |
| Pnpla2 | chemical |
| Acas2 | uniprot |
| Acadm | uniprot |
| Echs1 | uniprot |
| Hadha | uniprot |
| Gpd2 | uniprot |
| Acsl5 | uniprot |
| Acadl | uniprot |
| Beta Oxidation 1 MAPP | |
| Beta Oxidation 2 MAPP | |
| Beta Oxidation 3 MAPP | |
| This MAPP is only present for statistical purpose, | |
| to help evaluate all beta-oxidation MAPPS at once. | |
| Omit the 3 individual sub-mapps from statistical | |
| evaluation to prevent redundancy. |
| ADH1B | uniprot |
| Adh1 | uniprot |
| Cyp2d6 | |
| Cyp2e1 | uniprot |
| CYP2A6 | uniprot |
| Cyp4a11 | uniprot |
| CYP3A4 | uniprot |
| Cyp1a2 | uniprot |
| Cyp1a1 | uniprot |
| Adh1c | chemical |
| Adh4 | uniprot |
| Adh6 | uniprot |
| Adh7 | uniprot |
| Aldh1a1 | uniprot |
| Aldh2 | uniprot |
| CH3-(CH2)10-COO- | |
| HO-CH-(CH2)10-COO- | |
| HOC-(CH2)10-COO- | |
| -OOC-(CH2)10-COO- | |
| Beta Oxidation |
| Ech1 | uniprot | |
| Echs1 | uniprot | |
| Hadhsc | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Fasn | uniprot | |
| Acas2 | uniprot | |
| Acsl6 | uniprot | |
| Acsl5 | uniprot | |
| Acsl4 | uniprot | |
| Acsl3 | uniprot | |
| Acsl1 | uniprot | |
| Scd1 | uniprot | |
| Decr1 | uniprot | |
| Pecr | uniprot | |
| Mecr | uniprot | |
| Acaa2 | uniprot | |
| Pc | ||
| Acly | uniprot | |
| Fasn | uniprot | |
| ACACA | uniprot | |
| Acacb | chemical | |
| Echdc3 | ||
| Echdc2 | ||
| Echdc1 | ||
| Oxaloacetate | hmdbid:HMDB00223 | |
| Pyruvate | hmdbid:HMDB00243 | |
| TCA Cycle | ||
| Mitochondrion | ||
| Cytosol | ||
| Citrate | hmdbid:HMDB00094 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Acetyl-ACP | chemical | |
| Acetyl-synthase | ||
| Malonyl-CoA | hmdbid:HMDB01175 | |
| Malonyl-ACP | chemical | |
| Acetoacetyl-ACP | chemical | |
| beta-hydroxybutyryl | chemical | |
| Crotonoyl-ACP | chemical | |
| Butyryl-ACP | chemical | |
| less than 6 iterations | ||
| Palmitoyl-ACP | chemical | |
| 6 iterations | ||
| Palmitate | hmdbid:HMDB00220 | |
| 3-ketoacyl-CoA | chemical | |
| 3-L-Hydroxyacyl-CoA | chemical | |
| trans-delta2-enoyl-CoA | chemical | |
| Acyl-CoA (n+2) | ||
| Long-Chain fatty acid | ||
| Fatty acyl CoA | ||
| See Triacylglyceride Synthesis MAPP |
| Thbs4 | uniprot | |
| Tnr | uniprot | |
| Vtn | uniprot | |
| Vwf | uniprot | |
| Lamc1 | uniprot | |
| Col5a3 | ||
| Egf | uniprot | |
| Figf | uniprot | |
| Hgf | uniprot | |
| Igf1 | uniprot | |
| Pdgfa | uniprot | |
| Pgf | uniprot | |
| Pelo | uniprot | |
| Itga7 | uniprot | |
| Itgam | uniprot | |
| Itgb1 | uniprot | |
| Itgb2 | uniprot | |
| Itgb4 | uniprot | |
| Itgb6 | uniprot | |
| Itgb7 | uniprot | |
| Rap1a | uniprot | |
| Rap1b | uniprot | |
| Shc1 | uniprot | |
| Shc3 | uniprot | |
| Zyx | uniprot | |
| Cav | uniprot | |
| Cav3 | uniprot | |
| Fyn | uniprot | |
| Grb2 | uniprot | |
| Src | uniprot | |
| Ilk | uniprot | |
| Cav2 | uniprot | |
| Actn1 | uniprot | |
| Chad | ||
| Col2a1 | uniprot | |
| Col3a1 | uniprot | |
| Col4a1 | uniprot | |
| Col4a4 | ||
| Col5a1 | uniprot | |
| Col1a1 | uniprot | |
| Col1a2 | uniprot | |
| Fn1 | uniprot | |
| Ibsp | uniprot | |
| Lamc2 | uniprot | |
| Reln | uniprot | |
| Spp1 | uniprot | |
| Blk | uniprot | |
| Egfr | uniprot | |
| Erbb2 | uniprot | |
| Fgr | uniprot | |
| Flt1 | uniprot | |
| Hck | uniprot | |
| Igf1r | uniprot | |
| Met | ||
| Pdgfra | uniprot | |
| Pdgfrb | uniprot | |
| Srms | uniprot | |
| Txk | uniprot | |
| Tesk2 | uniprot | |
| Tnk2 | uniprot | |
| Araf | uniprot | |
| Mapk7 | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Mapk12 | uniprot | |
| Mapk1 | uniprot | |
| Mapk6 | uniprot | |
| Map2k2 | uniprot | |
| Map2k3 | uniprot | |
| Map2k1 | uniprot | |
| Ptk2 | uniprot | |
| Arhgap5 | uniprot | |
| Rhob | uniprot | |
| Pxn | uniprot | |
| Capn1 | uniprot | |
| Rhoa | uniprot | |
| Pdpk1 | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Rock1 | uniprot | |
| Rock2 | uniprot | |
| Pip5k1c | uniprot | |
| Mylk2 | uniprot | |
| Actb | uniprot | |
| Actg1 | uniprot | |
| Gsk3b | uniprot | |
| Pik3r1 | uniprot | |
| Pik3r2 | uniprot | |
| Pik3cb | uniprot | |
| Pten | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Pak1 | uniprot | |
| Pak3 | uniprot | |
| Pak2 | uniprot | |
| Pdgfc | chemical | |
| Vegfa | uniprot | |
| Vegfb | uniprot | |
| Vegfc | uniprot | |
| Bcar1 | uniprot | |
| Crk | uniprot | |
| Rapgef1 | chemical | |
| Cdc42 | uniprot | |
| Bad | ||
| Bcl2 | uniprot | |
| Birc2 | uniprot | |
| Birc3 | uniprot | |
| Birc4 | uniprot | |
| Mapk9 | uniprot | |
| Jun | uniprot | |
| Ccnd1 | uniprot | |
| Ccnd2 | uniprot | |
| Col11a1 | uniprot | |
| Col11a2 | uniprot | |
| Col4a2 | uniprot | |
| Col5a2 | ||
| Col6a2 | uniprot | |
| Comp | uniprot | |
| Lama1 | uniprot | |
| Lama2 | uniprot | |
| Lama3 | uniprot | |
| Lama4 | uniprot | |
| Lama5 | uniprot | |
| Lamb1 | uniprot | |
| Lamb2 | uniprot | |
| Lamb3 | uniprot | |
| Thbs1 | uniprot | |
| Thbs2 | uniprot | |
| Thbs3 | uniprot | |
| Tnc | uniprot | |
| Col4a6 | ||
| Tnxb | ||
| Tnn | uniprot | |
| Lamc3 | uniprot | |
| LOC235580 | ||
| Pdgfd | uniprot | |
| Pdgfb | uniprot | |
| Kdr | uniprot | |
| Ptk6 | uniprot | |
| Styk1 | uniprot | |
| Tnk1 | uniprot | |
| Itgb8 | ||
| Itgb5 | uniprot | |
| Itgb3 | uniprot | |
| Itgae | uniprot | |
| Itgav | uniprot | |
| Itgal | uniprot | |
| Itgad | uniprot | |
| Itgax | uniprot | |
| Itga8 | ||
| Itga9 | ||
| Itga10 | ||
| Itga11 | uniprot | |
| Itga2b | uniprot | |
| Itga6 | uniprot | |
| Itga5 | uniprot | |
| Itga4 | uniprot | |
| Itga3 | uniprot | |
| Itga2 | uniprot | |
| Farp2 | uniprot | |
| Flna | uniprot | |
| Tln1 | uniprot | |
| Pik3ca | uniprot | |
| Pik3cd | uniprot | |
| Pik3cg | uniprot | |
| Pik3r5 | uniprot | |
| Pik3r4 | uniprot | |
| Mapk8 | uniprot | |
| Ccnd3 | uniprot | |
| Ctnnb1 | uniprot | |
| Myl6 | uniprot | |
| Diap1 | uniprot | |
| Sos1 | uniprot | |
| Crk1 | uniprot | |
| Ha-Ras | uniprot | |
| Parvb | uniprot | |
| Vcl | uniprot | |
| Vasp | uniprot | |
| Dock1 | uniprot | |
| Raf1 | uniprot | |
| Braf | uniprot | |
| Braf | uniprot | |
| Sepp1 | uniprot | |
| Mapk4 | uniprot | |
| Elk1 | uniprot | |
| Rac3 | uniprot | |
| Vav1 | uniprot | |
| Akt3 | uniprot | |
| Ppp1r12a | uniprot | |
| Mylk | uniprot | |
| Pak4 | uniprot | |
| Pak6 | ||
| Pak7 | uniprot | |
| Phosphatidylinositiol | chemical | |
| signaling system | ||
| Cell Motility | ||
| Integrin alpha | ||
| Integrin beta | ||
| ITGA | ||
| ITGB | ||
| ECM-receptor interactions | ||
| Cytokine-cytokine receptor interactions | ||
| Receptor Tyrosine Kinases | ||
| RAF | ||
| MEK | hmdbid:HMDB00474 | |
| ERK | enzyme | uniprot |
| PKC | enzyme | uniprot |
| PIP2 | uniprot | |
| PIP3 | uniprot | |
| DNA | CHEBI:16991 | |
| Apoptosis | ||
| Cell Cycle | ||
| DNA | CHEBI:16991 | |
| Cell Proliferation | ||
| Wnt Signaling | ||
| FA turnover | ||
| Regulation of | ||
| actin cytoskeleton | ||
| Actin | uniprot | |
| Polymerization | chemical | |
| Stress Fiber/FA | ||
| formation | ||
| Filopodia | ||
| Lamellipodia | ||
| formation | ||
| Cell Survival | ||
| +p | ||
| -p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| -p | ||
| +p | ||
| +p | ||
| -p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p | ||
| +p |
| RGD:727874 | ||
| Rock1 | uniprot | |
| Mybph | uniprot | |
| RGD:620885 | ||
| Ppp1cb | uniprot | |
| Calm2 | uniprot | |
| Arhgdig | uniprot | |
| Cdc42 | uniprot | |
| Zfp29 | uniprot | |
| Pik3cd | uniprot | |
| Pak3 | uniprot | |
| Arhgdib | uniprot | |
| Pik3r2 | uniprot | |
| Diap1 | uniprot | |
| Pip5k2a | uniprot | |
| p140 Sra-1 | ||
| Posh | ||
| Mapk10 | uniprot | |
| Limk1 | uniprot | |
| Rock2 | uniprot | |
| Cit | uniprot | |
| Pkn1 | uniprot | |
| rhpn1 | uniprot | |
| Tnk2 | uniprot | |
| WAS | ||
| RGD:735144 | ||
| Map3k4 | uniprot | |
| Iqgap1 | uniprot | |
| Rhoa | uniprot | |
| Gna13 | uniprot | |
| Pfn1 | uniprot | |
| Pik3ca | uniprot | |
| Cfl1 | uniprot | |
| Cfl2 | uniprot | |
| Arhgef1 | uniprot | |
| Rac1 | uniprot | |
| Rps6kb1 | uniprot | |
| 13 | ||
| Activated Rho A | ||
| Cytokinesis | ||
| Actin | uniprot | |
| Membrane | ||
| Ruffling | ||
| Anti-Apoptotic | ||
| Actin Polymerization | ||
| Polymerization | chemical | |
| Filopodia Formation | ||
| Actin Reorganization | ||
| Stress Fiber | ||
| Disappearance | ||
| Disassembly of Actin | ||
| G | ||
| Cell-Cell Adhesion | ||
| Contraction & Actin-Myosin | ||
| Interaction, Focal Adhesion | ||
| Stress Fiber Contraction |
| CyclinD | uniprot | |
| Cdk | uniprot | |
| E2f5 | uniprot | |
| CyclinE | chemical | |
| Cdk4 | uniprot | |
| Cdk6 | uniprot | |
| Ccnd1 | uniprot | |
| Ccnd2 | uniprot | |
| Ccnd3 | uniprot | |
| CyclinD | uniprot | |
| Cdk | uniprot | |
| Cdk7 | uniprot | |
| Ccnh | uniprot | |
| Mnat1 | uniprot | |
| Ccna1 | uniprot | |
| Cdc2a | uniprot | |
| Ccnb1-rs1 | ||
| Ccng2 | uniprot | |
| Dp1 | uniprot | |
| E2f2 | uniprot | |
| E2f3 | uniprot | |
| E2f4 | ||
| E2f1 | uniprot | |
| E2f1 | uniprot | |
| Rb1 | uniprot | |
| Tfdp2 | uniprot | |
| Tfdp1 | uniprot | |
| Rb1 | uniprot | |
| E2f1 | uniprot | |
| Rbl1 | uniprot | |
| Rb1 | uniprot | |
| E2f6 | uniprot | |
| Pcna | uniprot | |
| LOC287961 | ||
| Pole2 | uniprot | |
| Pole | ||
| Pola2 | uniprot | |
| Rpa1 | uniprot | |
| Rpa2 | uniprot | |
| Rpa3 | uniprot | |
| Orc3l | uniprot | |
| Orc2l | uniprot | |
| Orc1l | uniprot | |
| Orc6l | uniprot | |
| Orc5l | uniprot | |
| RGD:735212 | ||
| Prim2 | uniprot | |
| RGD:621380 | ||
| Cdk7 | uniprot | |
| Cdk6 | uniprot | |
| Cdk4 | uniprot | |
| Cdc2a | uniprot | |
| RGD:1303018 | ||
| Mcm6 | uniprot | |
| Mcm5 | uniprot | |
| Mcm4 | uniprot | |
| Mcm3 | uniprot | |
| Mcm2 | uniprot | |
| Creb3l3 | ||
| Creb3l4 | ||
| Creb3 | uniprot | |
| Creb3l1 | ||
| RGD:1303317 | ||
| Creb1 | uniprot | |
| Cdc25a | uniprot | |
| Cdk | uniprot | |
| CyclinE | chemical | |
| Ccne1 | uniprot | |
| Ccne2 | uniprot | |
| Cdk2 | uniprot | |
| Wee1 | uniprot | |
| Myt1 | uniprot | |
| Cdk | uniprot | |
| Tp53 | uniprot | |
| Mdm2 | uniprot | |
| Atm | uniprot | |
| Tp53 | uniprot | |
| Gadd45a | uniprot | |
| Cdkn1a | uniprot | |
| Cdkn1b | uniprot | |
| Cdkn1c | uniprot | |
| Cdkn2d | uniprot | |
| Cdkn2c | uniprot | |
| RGD:2323 | ||
| Cdkn2b | uniprot | |
| Myc | uniprot | |
| G1 Cyclin | ||
| Cyclin Ds | chemical | |
| p | ||
| p | ||
| p | ||
| p | ||
| E2f | uniprot | |
| Rb | ||
| dp1 | uniprot | |
| Dependent Kinases | ||
| TTTCC/GCGC | ||
| Cell cycle DNA replication genes | ||
| G1 Phase | ||
| G1/S transition Phase | ||
| Dependent Kinases | ||
| Cyclin Es | chemical | |
| G1/S transition Cyclin | ||
| p | ||
| inactive | ||
| phosphorylation of proteins | ||
| involved in G1/S transition | ||
| DNA polymerases | uniprot | |
| DNA replication | ||
| origen recognition | ||
| complex | ||
| p | ||
| G1/S Cell Cycle | ||
| Checkpoint | ||
| G2 Phase-M phase | ||
| u | ||
| u | ||
| u | ||
| Degredation | ||
| p | ||
| e | ||
| cak | uniprot | |
| b | ||
| b | ||
| e |
| Gnb1 | uniprot |
| Gnb2 | uniprot |
| Gnb5 | uniprot |
| Gng5 | uniprot |
| Gng7 | uniprot |
| Gng11 | uniprot |
| Gnas | uniprot |
| Gnal | uniprot |
| Gnao | uniprot |
| Gnaz | uniprot |
| Gnai1 | uniprot |
| Gnai2 | uniprot |
| Gnai3 | uniprot |
| Gnaq | uniprot |
| Gna11 | uniprot |
| Gna15 | uniprot |
| Gna12 | uniprot |
| Arhgef1 | uniprot |
| Rhoa | uniprot |
| Slc9a1 | uniprot |
| Plcb3 | uniprot |
| Itpr1 | uniprot |
| Calm2 | uniprot |
| Kras2 | uniprot |
| Ppp3ca | uniprot |
| Ppp3cb | uniprot |
| RGD:621616 | |
| Prkca | uniprot |
| Prkcb1 | uniprot |
| Prkcc | uniprot |
| Prkcd | uniprot |
| Prkce | uniprot |
| Hint1 | uniprot |
| Prkch | uniprot |
| Prkcm | uniprot |
| PRKCQ | uniprot |
| Prkcz | uniprot |
| Kcnj3 | uniprot |
| Adcy2 | uniprot |
| Adcy3 | uniprot |
| Adcy4 | uniprot |
| Adcy5 | uniprot |
| Adcy6 | uniprot |
| Adcy7 | uniprot |
| Adcy8 | uniprot |
| Prkar1a | uniprot |
| Prkar2a | uniprot |
| Prkar2b | uniprot |
| Prkaca | uniprot |
| Pde1a | uniprot |
| Pde1b | uniprot |
| Pde1c | uniprot |
| Pde4d | uniprot |
| Pde7a | uniprot |
| Pde7b | uniprot |
| Pde8a | uniprot |
| Gng8 | uniprot |
| Gng2 | uniprot |
| Gng3 | uniprot |
| Gng4 | uniprot |
| Akap1 | uniprot |
| Akap2 | uniprot |
| Akap3 | uniprot |
| Akap4 | uniprot |
| Akap5 | uniprot |
| Akap6 | uniprot |
| RGD:1303071 | |
| Akap8 | uniprot |
| Akap9 | |
| Akap10 | uniprot |
| Akap11 | uniprot |
| Akap12 | |
| Akap13 | |
| Gnb3 | uniprot |
| Gnb4 | uniprot |
| Gng1 | uniprot |
| Adcy1 | uniprot |
| Adcy9 | uniprot |
| Hras1 | uniprot |
| Gna14 | uniprot |
| Nras | uniprot |
| Gna13 | uniprot |
| Prkar1b | uniprot |
| Prkacb | uniprot |
| Prkacg | |
| cAMP | hmdbid:HMDB00058 |
| IP3 | |
| Ca | |
| ++ | |
| s | |
| G | |
| G | |
| G | |
| q | |
| i | |
| 12/13 | |
| DAG | uniprot |
| Cytoskeletal | |
| Changes | |
| Cell | |
| Response | |
| Cell | |
| Response | |
| Transcription | |
| Transcription | |
| cAMP | hmdbid:HMDB00058 |
| Phosphatase 2B | |
| Protein Kinase A | uniprot |
| Phosphodiesterases | chemical |
| Adenylate Cyclases | uniprot |
| Protein Kinase C | uniprot |
| G | |
| G | |
| beta & gamma | |
| AKAPs |
| Cyp11a1 | uniprot | |
| Steroid delta-Isomerase | enzyme | uniprot |
| Corticosterone 18-Monooxy | ||
| 3-Oxo-5b-Steroid Dh | ||
| 3B-OH-delta-Steroid Dh | ||
| 20b-Hydroxysteroid Dh | ||
| Steroid delta-Isomerase | enzyme | uniprot |
| Cortisone beta-reductase | ||
| Hsd3b1 | uniprot | |
| Hsd3b1 | uniprot | |
| Hsd3b1 | uniprot | |
| Hsd3b | uniprot | |
| Cyp21a1 | uniprot | |
| Cyp11b1 | uniprot | |
| Cyp17a1 | uniprot | |
| Cyp17a1 | uniprot | |
| 3B-OH-delta-Steroid Dh | ||
| RGD:708361 | ||
| (R)20-hydroxysteroid Dh | ||
| RGD:708361 | ||
| Hsd11b2 | uniprot | |
| Hsd11b1 | uniprot | |
| HO | ||
| O | ||
| HO | ||
| Cholesterol | hmdbid:HMDB00067 | |
| From Cholersterol Biosynthesis | ||
| Progesterone | hmdbid:HMDB01830 | |
| Signaling | ||
| Steroid Hormone | CHEBI:26764 | |
| Pregnenolone | hmdbid:HMDB00253 | |
| 17-a-OH-Pregnenolone | chemical | |
| HO | ||
| =O | ||
| CH | ||
| OH | ||
| 17-a-OH-Progesterone | chemical | |
| To Androgen Synthesis | ||
| and Metabolism | ||
| Substrates in | ||
| have strucutures shown | ||
| 11-Deoxycorticosterone | hmdbid:HMDB00016 | |
| C | ||
| =O | ||
| CH | ||
| C | ||
| =O | ||
| CH | ||
| C | ||
| O | ||
| =O | ||
| CH | ||
| C | ||
| 3 | ||
| 3 | ||
| 3 | ||
| 2 | ||
| OH | ||
| HO | ||
| OH | ||
| =O | ||
| CH | ||
| C | ||
| 3 | ||
| O | ||
| O | ||
| =O | ||
| CH | ||
| C | ||
| 2 | ||
| OH | ||
| HO | ||
| OH | ||
| 11-Deoxycortisol | hmdbid:HMDB00015 | |
| Cortisol | hmdbid:HMDB00063 | |
| Cortisone | hmdbid:HMDB02802 | |
| 18-Hydroxy-Corticosterone | chemical | |
| O | ||
| =O | ||
| CH | ||
| C | ||
| 2 | ||
| OH | ||
| C | ||
| O | ||
| H | ||
| HO | ||
| Aldosterone | hmdbid:HMDB00037 | |
| 5b-Pregnan-18-al | chemical | |
| 3a,11b,21-Trihydroxy-20-Oxo- | chemical | |
| 5b-Pregnan-18-al | chemical | |
| 11b, 21-Dihydroxy-3,20- | ||
| 17a,21-Dihydroxy-5b- | chemical | |
| Pregnane-3,11,20-trione | chemical | |
| Urocortisone | hmdbid:HMDB00903 | |
| Urocortisol | hmdbid:HMDB00949 | |
| Cortisol | hmdbid:HMDB00063 | |
| Cortolone | hmdbid:HMDB03180 | |
| Pregnane 3,20-dione | hmdbid:HMDB03759 | |
| 11b,17a 21-Trihydroxy-5b | ||
| Glucuronides | hmdbid:HMDB03141 | |
| 3a-OH-5b-Pregnane-20-one | chemical | |
| 5b-Pregnane-3,20-dione | hmdbid:HMDB03759 | |
| HO | ||
| CH | ||
| C | ||
| 3 | ||
| H | ||
| H | ||
| Corticosterone | hmdbid:HMDB01547 | |
| -OH | ||
| Pregnanediol | hmdbid:HMDB04025 | |
| Glucocorticoids | CHEBI:24261 | |
| * | ||
| * | ||
| * | ||
| Progesterone Degradation | ||
| teal |
| 1.8.1.13 | ||
| Anpep | uniprot | |
| Ggt1 | uniprot | |
| Gpx3 | uniprot | |
| 1.8.4.4 | ||
| 1.8.4.1 | ||
| 2.8.1.3 | ||
| 1.8.5.1 | ||
| 1.8.4.3 | ||
| 1.8.3.3 | ||
| 1.11.1.12 | ||
| 1.8.4.7 | ||
| 1.8.4.2 | ||
| 1.5.4.1 | ||
| G6pdx | uniprot | |
| 1.1.1.43 | ||
| Idh1 | uniprot | |
| Gsr | uniprot | |
| Gss | uniprot | |
| Gclc | uniprot | |
| Ggt1 | uniprot | |
| 3.4.11.4 | ||
| Anpep | uniprot | |
| Oplah | uniprot | |
| 2.3.2.4 | ||
| Ggt1 | uniprot | |
| 2.3.2.4 | ||
| 2.3.1.80 | ||
| 6.3.1.8 | ||
| 3.5.1.78 | ||
| Gpx1 | uniprot | |
| Gpx2 | uniprot | |
| Gpx4 | uniprot | |
| Gstm3 | uniprot | |
| Gsta5 | uniprot | |
| Gsta2 | uniprot | |
| Gstm2 | uniprot | |
| Gstt1 | uniprot | |
| Gstt2 | uniprot | |
| Gstm4 | ||
| Ggtla1 | uniprot | |
| Ggtla1 | uniprot | |
| Gclm | uniprot | |
| Ggtla1 | uniprot | |
| Glutamate metabolism | ||
| Taurine and hypotaurine | ||
| Cyanoamino | chemical | |
| Cysteine metabolism | ||
| Amino acid metabolism | ||
| 5-Oxoproline | hmdbid:HMDB00267 | |
| L-Cysteine | hmdbid:HMDB00574 | |
| L-Glutamate | hmdbid:HMDB00148 | |
| Cysteinyl-Glycine | chemical | |
| (5-L-Glutamyl) | ||
| Glutathione | hmdbid:HMDB00125 | |
| g-L-Glutamyl-L-cysteine | hmdbid:HMDB01049 | |
| Bis-g-glutamylcystine | chemical | |
| Gluthatione | ||
| NADPH | hmdbid:HMDB00221 | |
| NADP+ | hmdbid:HMDB00217 | |
| RX | ||
| R-S-Glutathione | CHEBI:17021 | |
| Glutamylcysteinyl- | chemical | |
| L-Glutamate | hmdbid:HMDB00148 | |
| R-S-Alanyl | chemical | |
| Glycine | hmdbid:HMDB00123 | |
| R-S-Alanine | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| R-S-Mercapturonate | chemical | |
| (reduced) | ||
| glycylspermidine | chemical | |
| glycine | hmdbid:HMDB00123 | |
| metabolism | ||
| acid metabolism | ||
| g-Glutamyl | chemical | |
| Cycle | ||
| -L-amino acid | chemical | |
| glutathione recycling | ||
| Glutathione utilization | ||
| Glutathione | hmdbid:HMDB00125 | |
| utilization | ||
| (oxidized) | ||
| L-Amino Acid | CHEBI:15705 | |
| Glycine | hmdbid:HMDB00123 |
| Pygm | uniprot | ||
| Pgm1 | uniprot | ||
| Phkg1 | uniprot | ||
| Phka1 | uniprot | ||
| Phkg2 | uniprot | ||
| Ppp2ca | uniprot | ||
| Ppp3cb | uniprot | ||
| Ppp2r2a | uniprot | ||
| Ppp2r5b | |||
| Gys2 | uniprot | ||
| Gyg1 | uniprot | ||
| Gys1 | uniprot | ||
| Gys3 | uniprot | ||
| Branching Enzyme | enzyme | ||
| Gsk3b | uniprot | ||
| Agl | uniprot | ||
| Ugp2 | uniprot | ||
| Glycogen | hmdbid:HMDB00757 | ||
| Glucose | hmdbid:HMDB00122 | ||
| Glucose-6-phosphate | hmdbid:HMDB01401 | ||
| Glucose-1-phosphate | hmdbid:HMDB01586 | ||
| UDP-Glucose + | |||
| Glycolysis | |||
| Glycogen (n-1) + Glucose-1-phosphate | |||
| Degradation | |||
| Synthesis | |||
| Phosphorylase Kinase B | |||
| cAMP | hmdbid:HMDB00058 | ||
| Ser/Thr Protein Phosphatase 2A | |||
| Glycogen | hmdbid:HMDB00757 | ||
| Glycogen (n+1) |
| Chrm1 | uniprot | |
| Chrm2 | uniprot | |
| Chrm3 | uniprot | |
| Chrm4 | uniprot | |
| Adra1a | uniprot | |
| Adra1b | uniprot | |
| Adra1d | uniprot | |
| Adra2b | uniprot | |
| Adra2c | uniprot | |
| Adra2a | uniprot | |
| Adrb2 | uniprot | |
| Adrb3 | uniprot | |
| Drd3 | uniprot | |
| Drd4 | uniprot | |
| C5r1 | uniprot | |
| C3ar1 | uniprot | |
| Bdkrb1 | uniprot | |
| Bdkrb2 | uniprot | |
| Grpr | uniprot | |
| Nmbr | uniprot | |
| Agtr1 | uniprot | |
| Agtr1a | uniprot | |
| Htr7 | uniprot | |
| Htr6 | uniprot | |
| Htr5b | uniprot | |
| Htr5a | uniprot | |
| Htr4 | uniprot | |
| Htr2a | uniprot | |
| Agtrl1 | uniprot | |
| Il8rb | uniprot | |
| Ccr3 | uniprot | |
| Cxcr4 | uniprot | |
| Ccr5 | uniprot | |
| Ccbp2 | uniprot | |
| Cxcr4 | uniprot | |
| Ccr5 | uniprot | |
| Cx3cr1 | uniprot | |
| Cckar | uniprot | |
| Cckar | uniprot | |
| Cckbr | uniprot | |
| Sstr2 | uniprot | |
| Sstr1 | uniprot | |
| Oprl | uniprot | |
| Oprk1 | uniprot | |
| Oprd1 | uniprot | |
| Ntsr2 | uniprot | |
| Ppyr1 | uniprot | |
| Npy1r | uniprot | |
| Mc5r | uniprot | |
| Mc3r | uniprot | |
| Ednrb | uniprot | |
| Sstr3 | uniprot | |
| Sstr5 | uniprot | |
| Sstr4 | uniprot | |
| Sstr5 | uniprot | |
| Avpr1a | uniprot | |
| Avpr1b | uniprot | |
| Oxtr | uniprot | |
| Galr1 | uniprot | |
| Galr3 | uniprot | |
| Galr2 | uniprot | |
| F2rl1 | uniprot | |
| Cmklr1 | uniprot | |
| Gabbr1 | uniprot | |
| Opn1sw | uniprot | |
| Opn1mw | uniprot | |
| Rho | uniprot | |
| Tshr | uniprot | |
| Lhcgr | uniprot | |
| Fshr | uniprot | |
| Ptger1 | uniprot | |
| Ptger2 | uniprot | |
| Ptger3 | uniprot | |
| Ptger4 | uniprot | |
| Ptgfr | uniprot | |
| Tbxa2r | uniprot | |
| Adora3 | uniprot | |
| Adora2b | uniprot | |
| Adora2a | uniprot | |
| P2ry1 | uniprot | |
| Cmkor1 | uniprot | |
| Mas1 | uniprot | |
| GPR87 | uniprot | |
| Mtnr1a | uniprot | |
| Gpr50 | uniprot | |
| Trhr | uniprot | |
| RGD:621262 | ||
| Ptafr | uniprot | |
| Cnr1 | uniprot | |
| Cnr2 | uniprot | |
| Adrb1 | uniprot | |
| Agtr2 | uniprot | |
| Ccr2 | uniprot | |
| Gpcr12 | uniprot | |
| Gpr19 | uniprot | |
| Gpr27 | uniprot | |
| Hrh1 | uniprot | |
| Hrh2 | uniprot | |
| Htr1a | uniprot | |
| Htr1b | uniprot | |
| Htr1d | uniprot | |
| Htr1f | uniprot | |
| Htr2c | uniprot | |
| Htr2b | uniprot | |
| P2ry2 | uniprot | |
| Brs3 | uniprot | |
| FPR-RS2 | ||
| FPR-RS1 | ||
| Fpr1 | uniprot | |
| Fprl1 | uniprot | |
| Fpr-rs4 | ||
| Fpr-rs3 | ||
| Ccr1 | uniprot | |
| Ccr6 | uniprot | |
| Ccr8 | uniprot | |
| Ccr9 | uniprot | |
| Ccr1l1 | uniprot | |
| Ccrl2 | uniprot | |
| Cxcr3 | uniprot | |
| Mc1r | uniprot | |
| Mc2r | uniprot | |
| Npy2r | uniprot | |
| Npy5r | uniprot | |
| Gpr83 | uniprot | |
| Oprm1 | uniprot | |
| F2r | uniprot | |
| Avpr2 | uniprot | |
| NTSR1 | uniprot | |
| NPY6R | uniprot | |
| F2rl3 | uniprot | |
| F2rl2 | uniprot | |
| Gpr37 | uniprot | |
| Gpr33 | uniprot | |
| Gpr44 | uniprot | |
| Gpr66 | uniprot | |
| Rgr | uniprot | |
| Opn4 | uniprot | |
| Rrh | uniprot | |
| OPN3 | uniprot | |
| Ptgdr | uniprot | |
| PTGIR | uniprot | |
| P2ry4 | uniprot | |
| Gpr35 | uniprot | |
| Ltb4r | uniprot | |
| Sucnr1 | uniprot | |
| P2y12 | uniprot | |
| GPR86 | uniprot | |
| Q9ESG6 | ||
| Q9D5Q2 | ||
| TCP10C | ||
| Gpr3 | uniprot | |
| Gpr63 | uniprot | |
| Gpr45 | uniprot | |
| Cysltr1 | uniprot | |
| Gpr65 | uniprot | |
| Cask | ||
| RGD:727952 | ||
| Amine | CHEBI:32952 | |
| Acetylcholine (muscarinic) | ||
| Adrenoceptors | ||
| Alpha Adrenoceptors | ||
| Beta Adrenoceptors | ||
| Dopamine | hmdbid:HMDB00073 | |
| Histamine | hmdbid:HMDB00870 | |
| Peptide | CHEBI:16670 CHEBI:16670 | |
| Angiotensin | uniprot | |
| Bombesin | uniprot | |
| Bradykinin | uniprot | |
| C5a anaphylatoxin | uniprot | |
| Fmet-leu-phe | ||
| APJ like | ||
| Interleukin-8 | uniprot | |
| Chemokine | ||
| C-C Chemokine | ||
| C-X-C Chemokine | ||
| CCK | uniprot | |
| Melanocortin | chemical | |
| Neuropeptide Y | uniprot | |
| Neurotensin | uniprot | |
| Opioid | ||
| Somatostatin | ||
| Thrombin | enzyme | uniprot |
| Vasopressin-like | ||
| Galanin | uniprot | |
| Proteinase activated | ||
| GPR37 / endothelin B-like | ||
| Chemokine receptor-like | ||
| Neuromedin U | ||
| Hormone protein | ||
| Follicle stimulating hormone | ||
| Lutropin-choriogonadotropic hormone | ||
| Thyrotropin | ||
| (Rhod)opsin | ||
| Rhodopsin Vertebrate | ||
| Rhodopsin Other | ||
| Olfactory | ||
| Prostanoid | CHEBI:26347 | |
| Prostaglandin | CHEBI:26333 | |
| Prostacyclin | hmdbid:HMDB01335 | |
| Thromboxane | hmdbid:HMDB03208 | |
| Nucleotide-like | ||
| Adenosine | hmdbid:HMDB00050 | |
| Purinoceptors | ||
| Cannabis | ||
| Platelet activating factor | ||
| Melatonin | hmdbid:HMDB01389 | |
| Class A Orphan/other | ||
| Thyrotropin-releasing hormone & Secretagogue | ||
| Endothelin |
| Calcrl | uniprot |
| Calcr | uniprot |
| Crhr2 | uniprot |
| Crhr1 | uniprot |
| Gcgr | uniprot |
| Glp1r | uniprot |
| Ghrhr | uniprot |
| Pthr1 | uniprot |
| Vipr1 | uniprot |
| Vipr2 | uniprot |
| Adcyap1r1 | uniprot |
| Cd97 | uniprot |
| Emr1 | uniprot |
| Calcitonin | uniprot |
| Corticotropin releasing factor | uniprot |
| Glucagon | uniprot |
| Growth hormone-releasing hormone | uniprot |
| Parathyroid hormone | |
| PACAP | uniprot |
| Vasoactive intestinal polypeptide | uniprot |
| EMR1 | uniprot |
| Grm3 | uniprot |
| Grm8 | uniprot |
| Grm1 | uniprot |
| Casr | uniprot |
| RGD:735022 | |
| RGD:708515 | |
| RGD:727942 | |
| RGD:708398 | |
| Gabbr1 | uniprot |
| Sel1h | uniprot |
| V2R14 | |
| GPRC5D | uniprot |
| Metabotropic glutamate | chemical |
| Extracellular calcium-sensing | |
| Putative pheromone Receptors | |
| GABA-B | |
| Orphan GPRC5 |
| Adora1 | uniprot | |
| Ednra | uniprot | |
| Mc4r | uniprot | |
| Grm1 | uniprot | |
| Tacr3 | uniprot | |
| Olr226 | uniprot | |
| Olr1361 | uniprot | |
| Olr287 | uniprot | |
| Olr226 | uniprot | |
| Olr226 | uniprot | |
| Fzd2 | uniprot | |
| Fzd2 | uniprot | |
| OLFR60 | ||
| OLFR59 | ||
| OLFR58 | ||
| OLFR56 | ||
| OLFR57 | ||
| OLFR55 | ||
| OLFR54 | ||
| OLFR53 | ||
| OLFR52 | ||
| OLFR51 | ||
| OLFR50 | ||
| OLFR48 | ||
| OLFR47 | ||
| OLFR46 | ||
| OLFR45 | ||
| OLFR44 | ||
| OLFR43 | ||
| OLFR42 | ||
| Vipr1 | uniprot | |
| Smo | uniprot | |
| Adora3 | uniprot | |
| Drd1a | uniprot | |
| GPR37L1 | uniprot | |
| Adrb2 | uniprot | |
| Adora3 | uniprot | |
| Pcdha4 | uniprot | |
| Edg1 | uniprot | |
| GPR37L1 | uniprot | |
| Fzd1 | uniprot | |
| Adrb1 | uniprot | |
| Drd5 | uniprot | |
| Gabbr1 | uniprot | |
| Edg5 | uniprot | |
| Oprk1 | uniprot | |
| Edg5 | uniprot | |
| Gpr7 | uniprot | |
| Ccr7 | uniprot | |
| Gpr2 | uniprot | |
| Xcr1 | uniprot | |
| OLFR4-3 | ||
| OA1 | uniprot | |
| Drd2 | uniprot | |
| Gpr56 | uniprot | |
| CELSR1 | uniprot | |
| Celsr2 | uniprot | |
| Cysltr1 | uniprot | |
| Gpr88 | uniprot | |
| DFY | ||
| Grca | ||
| Mrgprh | uniprot | |
| Gpr84 | uniprot | |
| Ltb4r2 | uniprot | |
| Gpr73 | uniprot | |
| Gpr132 | uniprot | |
| GPCR14 | ||
| OLFR4 | ||
| OLFR4 | ||
| OLFR4 | ||
| OLFR3 | ||
| OLFR7 | ||
| OLFR13 | ||
| OLFR12 | ||
| OLFR11 | ||
| OLFR10 | ||
| Sstr5 | uniprot | |
| Fzd9 | uniprot | |
| GPRC2A-RS3 | ||
| GPRC2A-RS2 | ||
| CASR-RS1 | ||
| V2R7 | ||
| V2R6 | ||
| V2R5 | ||
| V2R3 | ||
| V1rb6 | uniprot | |
| V1rb7 | uniprot | |
| V1rb9 | uniprot | |
| V1RC8 | ||
| V1rc5 | ||
| V1RC9 | ||
| V1RC7 | ||
| V1rc6 | ||
| V1RC3 | ||
| V1rc1 | ||
| V1rc2 | ||
| V1RC4 | ||
| V1RB3 | ||
| V1RB1 | ||
| V1RB8 | ||
| V1RB4 | ||
| V1R5 | ||
| V1RA1 | ||
| V1RA3 | ||
| V1RA4 | ||
| V1RA5 | ||
| V1RA6 | ||
| V1ra8 | uniprot | |
| V1RA9 | ||
| V1RA1 | ||
| V1ra7 | uniprot | |
| V1RA2 | ||
| Olr1413 | ||
| Olr728 | ||
| Olr1398 | ||
| OLFR28 | ||
| OLFR19 | ||
| Olr1307 | ||
| OLFR33 | ||
| OLFR18 | ||
| OLFR22 | ||
| OLFR23 | ||
| OLFR24 | ||
| OLFR29 | ||
| OLFR31 | ||
| OLFR20 | ||
| OLFR27 | ||
| Olr737 | ||
| HTR1DA | uniprot | |
| HTR1DB | uniprot | |
| Edg8 | uniprot | |
| Tas1r1 | uniprot | |
| Cask | ||
| Rrh | uniprot | |
| Gpr83 | uniprot | |
| OLFR56 | ||
| Oprl | uniprot | |
| OLFR46 | ||
| RSVP | ||
| D1DR | ||
| Fzd9 | uniprot | |
| Adora1 | uniprot | |
| OLFR89 | ||
| OLFR62 | ||
| OLFR61 | ||
| FZD7 | uniprot | |
| Cd97 | uniprot | |
| Celsr2 | uniprot | |
| Smoothened | ||
| Vomeronasal receptors (V1R & V3R) | ||
| Putative / unclassified GPCRs | ||
| Other Chemokine Receptors | ||
| Fragments |
| Ptch1 | uniprot |
| Shh | |
| Cdc2a | uniprot |
| Ptch1 | uniprot |
| Ptch1 | uniprot |
| Dhh | uniprot |
| Smo | uniprot |
| Ihh | uniprot |
| Ptch1 | uniprot |
| Ptch1 | uniprot |
| Ihh | uniprot |
| GLI3 | uniprot |
| SKI | uniprot |
| Sufu | uniprot |
| Sap18 | uniprot |
| Sin3a | uniprot |
| Gli1 | uniprot |
| GAS1 | uniprot |
| Crebbp | uniprot |
| Dyrk1a | uniprot |
| Gli2 | chemical |
| Stk36 | uniprot |
| Sufu | uniprot |
| Cdc2a | uniprot |
| Ccnb1 | uniprot |
| Gli1 | uniprot |
| Gli2 | chemical |
| GLI3 | uniprot |
| Ptch1 | uniprot |
| Sufu | uniprot |
| Rab23 | uniprot |
| Rab23 | uniprot |
| Ccnb1 | uniprot |
| Smo | uniprot |
| Igf2 | uniprot |
| Dhh | uniprot |
| Shh | |
| Shh | |
| Dhh | uniprot |
| Ihh | uniprot |
| Shh | |
| RGD1564108 | |
| RGD1564108 | |
| RGD1564108 | |
| Ptch1 | uniprot |
| Translocation | |
| Plasma membrane | |
| Cytoplasm | |
| Endosome | |
| Nucleus | CHEBI:33252 |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| PM->EN | |
| CY->NU | |
| CY->PM | |
| PM->EN | |
| Molecular Association | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| Gene Symbol | |
| Activation | chemical |
| D | |
| Inhibition | chemical |
| Accession Number: NetPath_10; cellmap:10 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| EN | |
| NU | |
| D | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Methylation | chemical |
| Demethylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Extracellular | |
| EC | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Palmitoylation | chemical |
| Glycosylation |
| Map3k1 | uniprot |
| Casp8 | uniprot |
| Casp3 | uniprot |
| Fadd | uniprot |
| Bid | |
| Casp2 | uniprot |
| Casp6 | uniprot |
| Casp7 | uniprot |
| Hspa1a | uniprot |
| RGD:619831 | |
| Casp8 | uniprot |
| Pdcd8 | uniprot |
| Cycs | uniprot |
| Apaf1 | uniprot |
| Casp9 | |
| Cycs | uniprot |
| Nfkb1 | uniprot |
| Hspa1a | uniprot |
| Hspa1a | uniprot |
| Fadd | uniprot |
| Tnfrsf1a | uniprot |
| Mapk10 | uniprot |
| Ripk1 | uniprot |
| TNF-alpha | uniprot |
| STRESS | |
| Mitochondria | |
| APOPTOSIS | |
| CELL SURVIVAL | |
| Ik alpha | |
| degradation of | |
| Activation | chemical |
| of proteins | |
| degradation | |
| (activation of NFkB) | |
| Inhibition | chemical |
| Apoptosome | |
| Inhibition | chemical |
| NF-kB | |
| FAS-Ligand | |
| Proteasome | enzyme |
| pathway | |
| Inhibition | chemical |
| Inhibition | chemical |
| Tcf8 | uniprot |
| Myog | uniprot |
| Il1a | uniprot |
| ? | |
| Eif4e | uniprot |
| Atf3 | uniprot |
| Ifng | uniprot |
| Dusp14 | uniprot |
| Nr4a3 | uniprot |
| MINOR | uniprot |
| LOC360950 | |
| Jund | uniprot |
| Il1r1 | uniprot |
| Cyr61 | uniprot |
| Gdf8 | uniprot |
| Eif4ebp1 | uniprot |
| Vegfa | uniprot |
| Il18 | uniprot |
| Adam10 | uniprot |
| Ankrd1 | uniprot |
| Dtr | uniprot |
| Ifrd1 | uniprot |
| -634 | |
| -698 | |
| +1 | |
| ? | |
| angiogenesis | |
| protein synthesis | |
| proliferative response | |
| +500 | |
| +296 | |
| correlate to all 4 MINOR probes | |
| HB-EGF correlated |
| Id1 | uniprot | |
| Id2 | uniprot | |
| Id3 | uniprot | |
| Id4 | uniprot | |
| Id2 | uniprot | |
| Rb1 | uniprot | |
| Rbl2 | uniprot | |
| RBL1 | uniprot | |
| Tcfe2a | uniprot | |
| Myod1 | uniprot | |
| CDK2 | uniprot | |
| Ccna2 | uniprot | |
| Ccne1 | uniprot | |
| Elk1 | uniprot | |
| Elk4 | uniprot | |
| Elk3 | uniprot | |
| Psmd4 | uniprot | |
| Hes1 | uniprot | |
| PAX5 | uniprot | |
| Pax2 | uniprot | |
| Pax8 | uniprot | |
| Myf5 | uniprot | |
| Myf6 | uniprot | |
| Myog | uniprot | |
| Tcf12 | uniprot | |
| Srebf1 | uniprot | |
| Msc | uniprot | |
| Mnda | chemical | |
| Bmp2 | uniprot | |
| Bmpr2 | uniprot | |
| Vegfa | uniprot | |
| Flt1 | uniprot | |
| KDR | hmdbid:HMDB06226 | uniprot |
| Smad1 | uniprot | |
| Smad4 | uniprot | |
| Smad5 | uniprot | |
| Atf3 | uniprot | |
| Smad3 | uniprot | |
| Tgif | uniprot | |
| Acvrl1 | uniprot | |
| Smad4 | uniprot | |
| Smad5 | uniprot | |
| Smad1 | uniprot | |
| TCR | ||
| LCK | uniprot | |
| RAS | uniprot | |
| MAPK | enzyme | uniprot |
| ERK | enzyme | uniprot |
| Igf1r | uniprot | |
| Igf1 | uniprot | |
| Irs1 | uniprot | |
| PI3K | uniprot | |
| Ctnnb1 | uniprot | |
| Tert | uniprot | |
| Nfkb1 | uniprot | |
| Rela | uniprot | |
| Bmp6 | uniprot | |
| Cd40lg | uniprot | |
| Atf3 | uniprot | |
| Smad3 | uniprot | |
| Egf | uniprot | |
| TCF7L2 | uniprot | |
| Gene Symbol | ||
| Ngfb | uniprot | |
| ID Gene Regulation | ||
| D | ||
| D | ||
| D | ||
| D | ||
| D | ||
| Control | ||
| Ligand | ||
| Receptor | ||
| Molecule in the Pathway | ||
| P | ||
| P | ||
| P | ||
| CY -> NU | ||
| Cytoplasm | ||
| Extracellular | ||
| Proteins in a complex interaction | ||
| Molecular association | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| Phosphorylation | chemical | |
| Activation | chemical | |
| Translocation | ||
| CY | ||
| EC | ||
| Accession Number: NetPath_5; cellmap:5 | ||
| Enzyme complex | ||
| Autophosphorylation | chemical | |
| Acetylation | chemical | |
| Deacetylation | chemical | |
| Glycosylation | ||
| Methylation | chemical | |
| Demethylation | chemical | |
| Palmitoylation | chemical | |
| Dephosphorylation | chemical | |
| Proteolytic cleavage | ||
| Sumoylation | chemical | |
| Desumoylation | ||
| Ubiquitination | ||
| Deubiquitination | ||
| Inhibition | chemical | |
| Recruitment | ||
| EN | ||
| Endosome | ||
| ER | ||
| Endoplasmic reticulum | ||
| GO | ||
| Golgi apparatus | ||
| Mitochondria | ||
| MT | ||
| Nucleus | CHEBI:33252 | |
| NU | ||
| PM | ||
| Plasma membrane |
| Il1b | uniprot | |
| Il1rn | uniprot | |
| Il1rap | uniprot | |
| Il1r1 | uniprot | |
| Il1a | uniprot | |
| Il1b | uniprot | |
| Il1rn | uniprot | |
| Il1r2 | uniprot | |
| Il1r2 | uniprot | |
| Il1rap | uniprot | |
| Il1r2 | uniprot | |
| Myd88 | uniprot | |
| Il1r1 | uniprot | |
| Il1r1 | uniprot | |
| IRAK4 | uniprot | |
| IRAK3 | uniprot | |
| TOLLIP | uniprot | |
| PELI1 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7 | uniprot | |
| MAPK8 | uniprot | |
| MAP3K14 | uniprot | |
| CHUK | enzyme | uniprot |
| CHUK | enzyme | uniprot |
| IKBKAP | uniprot | |
| SQSTM1 | uniprot | |
| PRKCZ | uniprot | |
| Ptpns1 | uniprot | |
| PTPN11 | uniprot | |
| TOLLIP | uniprot | |
| Il1a | uniprot | |
| Irak2 | chemical | |
| IRAK4 | uniprot | |
| PELI1 | uniprot | |
| MAP3K14 | uniprot | |
| Il1a | uniprot | |
| Il1b | uniprot | |
| CAPN1 | uniprot | |
| CAPNS1 | uniprot | |
| CASP1 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP2 | uniprot | |
| Ptpns1 | uniprot | |
| MAPK1 | uniprot | |
| AKT1 | uniprot | |
| MAP3K7IP2 | uniprot | |
| MAP3K7IP1 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP2 | uniprot | |
| Traf6 | uniprot | |
| MAP3K7 | uniprot | |
| MAP3K7IP1 | uniprot | |
| NFKBIA | uniprot | |
| NFKBIB | uniprot | |
| Gene Symbol | ||
| Il1a | uniprot | |
| Il1b | uniprot | |
| PTPN11 | uniprot | |
| MAPK1 | uniprot | |
| MAP2K1 | uniprot | |
| MAPK3 | uniprot | |
| NFKBIA | uniprot | |
| RELA | uniprot | |
| RELA | uniprot | |
| NFKB1 | uniprot | |
| PLCG1 | uniprot | |
| Irak1 | uniprot | |
| Irak1 | uniprot | |
| Traf6 | uniprot | |
| Traf6 | uniprot | |
| Traf6 | uniprot | |
| Irak1 | uniprot | |
| Irak1 | uniprot | |
| Irak4 | uniprot | |
| Traf6 | uniprot | |
| Traf6 | uniprot | |
| Irak1 | uniprot | |
| Irak1 | uniprot | |
| D | ||
| CY -> NU | ||
| PM -> CY | ||
| PM -> CY | ||
| D | ||
| D | ||
| Accession Number: NetPath_13 | ||
| D | ||
| Receptor | ||
| Ligand | ||
| Molecule in the pathway | ||
| Proteins in a complex interaction | ||
| Enzyme complex | ||
| Molecular association | ||
| (Protein-protein interaction) | ||
| Reaction through unknown mechanisms/molecules | ||
| Phosphorylation | chemical | |
| Autophosphorylation | chemical | |
| Dephosphorylation | chemical | |
| Palmitoylation | chemical | |
| Ubiquitination | ||
| Proteolytic cleavage | ||
| Glycosylation | ||
| Acetylation | chemical | |
| Sumoylation | chemical | |
| Methylation | chemical | |
| Recruitment | ||
| Activation | chemical | |
| Inhibition | chemical | |
| Translocation | ||
| PM | ||
| Plasma membrane | ||
| CY | ||
| Cytoplasm | ||
| NU | ||
| Nucleus | CHEBI:33252 | |
| EN | ||
| Endosome | ||
| GO | ||
| Golgi apparatus | ||
| MT | ||
| Mitochondria | ||
| CY->EX | ||
| CY->EX | ||
| Deubiquitination | ||
| Deacetylation | chemical | |
| Desumoylation | ||
| Demethylation | chemical | |
| EC | ||
| Extracellular | ||
| D | ||
| D | ||
| D | ||
| CY -> NU | ||
| CY -> NU | ||
| Control |
| Il2rg | uniprot |
| IL2RB | uniprot |
| Il2ra | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Jak1 | uniprot |
| Jak3 | uniprot |
| Jak2 | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Ptpn6 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Gab2 | uniprot |
| Syk | uniprot |
| Irs1 | uniprot |
| Irs2 | uniprot |
| Stam2 | uniprot |
| RGD1564499 | |
| Socs3 | uniprot |
| Plcb1 | uniprot |
| Rps6kb1 | uniprot |
| PIK3CA | uniprot |
| Pik3cb | uniprot |
| Pik3cd | uniprot |
| Pik3cg | uniprot |
| Fyn | uniprot |
| Akt1 | uniprot |
| Foxo3a | |
| Tert | uniprot |
| Lyn | |
| Ptpn11 | uniprot |
| Shc1 | uniprot |
| Raf1 | uniprot |
| Grb2 | uniprot |
| Ptk2b | uniprot |
| Cd53 | uniprot |
| Icam1 | uniprot |
| Sos1 | uniprot |
| Socs1 | uniprot |
| Cish | uniprot |
| Gnb2l1 | uniprot |
| Crkl | uniprot |
| RGD1561386 | |
| SHB | uniprot |
| Crk | uniprot |
| Nmi | uniprot |
| Ets1 | uniprot |
| Nr3c1 | uniprot |
| Prkcz | uniprot |
| Itm2b | uniprot |
| Bcl2 | uniprot |
| IFNA1 | uniprot |
| Frap1 | uniprot |
| Hspca | uniprot |
| MGC112775 | |
| Eif4e | uniprot |
| Creb1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Vav1 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Ybx1 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Ybx1 | uniprot |
| Tert | uniprot |
| Akt1 | uniprot |
| Raf1 | uniprot |
| Kras | uniprot |
| Mapk8 | uniprot |
| Mapk14 | uniprot |
| Mapkapk2 | uniprot |
| Mapk9 | uniprot |
| Chuk | uniprot |
| Eif3s9 | uniprot |
| Akt1 | uniprot |
| Stat3 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Stat1 | uniprot |
| Crk | uniprot |
| Il2 | uniprot |
| Il2 | uniprot |
| Lck | uniprot |
| Ets2 | uniprot |
| Molecular association | |
| Translocation | |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| Inhibition | chemical |
| Activation | chemical |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> NU | |
| CY -> PM | |
| CY -> NU | |
| PM -> CY | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| D | |
| D | |
| D | |
| Gene Symbol | |
| Accession Number: NetPath_14 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Reactions through unknown mechanisms/molecules | |
| Plasma membrane | |
| Nucleus | CHEBI:33252 |
| (Protein-protein interaction) | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitolyation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Sumoylation | chemical |
| Recruitment | |
| Control | |
| CY | |
| EC | |
| EN | |
| ER | |
| GO | |
| MT | |
| MT | |
| PM | |
| Cytoplasm | |
| Extracellular | |
| Endoplasmic reticulum | |
| Endosome | |
| Golgi apparatus | |
| Mitochondrion | |
| NU | |
| NU | |
| Nucleus | CHEBI:33252 |
| IL3 | uniprot |
| Il3ra | uniprot |
| IL3 | uniprot |
| IL3 | uniprot |
| Csf2rb1 | uniprot |
| Il3ra | uniprot |
| Csf2rb1 | uniprot |
| PIK3CA | uniprot |
| Pik3cd | uniprot |
| Hras | uniprot |
| Tec | uniprot |
| Vav1 | uniprot |
| Jak1 | uniprot |
| Jak2 | uniprot |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Lyn | |
| Syk | uniprot |
| Hck | uniprot |
| Fyn | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Stat6 | uniprot |
| Stat5b | uniprot |
| Stat3 | uniprot |
| Rara | uniprot |
| Rxra | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Akt1 | uniprot |
| Ywhaz | uniprot |
| RGD1564385 | |
| Cish | uniprot |
| Gnb2l1 | uniprot |
| Prkcb1 | uniprot |
| Shc1 | uniprot |
| Ywhaq | uniprot |
| Ywhab | uniprot |
| Gab2 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Inpp5d | |
| Gab1 | uniprot |
| Rapgef1 | chemical |
| Crkl | uniprot |
| RGD1561386 | |
| Crk | uniprot |
| PILRB | uniprot |
| Bad | |
| Bcl2l1 | uniprot |
| Bcl2 | uniprot |
| Bax | uniprot |
| Bcl2l11 | uniprot |
| Ppp2ca | uniprot |
| Creb1 | uniprot |
| Ptk2 | uniprot |
| Pxn | uniprot |
| Src | uniprot |
| Socs2 | uniprot |
| Socs3 | uniprot |
| Dnm1 | uniprot |
| Vcl | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Rac1 | uniprot |
| Rac2 | uniprot |
| Mapk8 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Gata1 | uniprot |
| Gata2 | uniprot |
| Prkaca | uniprot |
| Pak1 | uniprot |
| Shc1 | uniprot |
| Prkca | uniprot |
| Prkca | uniprot |
| Nfkb1 | uniprot |
| Nfkb1 | uniprot |
| Slc2a1 | uniprot |
| Slc2a1 | uniprot |
| Bad | |
| Mapk3 | uniprot |
| TYK2 | uniprot |
| Gsk3a | uniprot |
| Gsk3b | uniprot |
| Csen | uniprot |
| MAPK7 | uniprot |
| Foxo1a | uniprot |
| Hspb1 | uniprot |
| Mapk14 | uniprot |
| Atf2 | uniprot |
| Atf1 | uniprot |
| Mras | uniprot |
| Kras | uniprot |
| RPS6KB2 | uniprot |
| Rap1a | uniprot |
| BIRC5 | uniprot |
| Mapkapk2 | uniprot |
| Sfpi1 | uniprot |
| Cdc42 | uniprot |
| RGD1565643 | |
| Tnfrsf1b | uniprot |
| Id1 | uniprot |
| Selp | uniprot |
| Fcer2a | uniprot |
| Mapk9 | uniprot |
| Chek1 | uniprot |
| Matk | uniprot |
| Mmp2 | uniprot |
| Mmp9 | uniprot |
| Gene Symbol | |
| IL3 | uniprot |
| Lck | uniprot |
| Molecular Association | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| D | |
| CY->PM | |
| CY->NU | |
| CY->PM | |
| CY->NU | |
| D | |
| D | |
| Activation | chemical |
| Plasma membrane | |
| CY->PM | |
| D | |
| MT->CY | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Mitochondrion | |
| Accession Number: NetPath_15 | |
| Molecule in the pathway | |
| Receptor | |
| Ligand | |
| Proteins in a complex interaction | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| Translocation | |
| Inhibition | chemical |
| PM | |
| CY | |
| NU | |
| MT | |
| Enzyme complex | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Dephosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| Deacetylation | chemical |
| Acetylation | chemical |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA | |
| MA |
| Il2rg | uniprot |
| Il4ra | uniprot |
| Il4 | uniprot |
| RGD1564385 | |
| Inpp5d | |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Jak1 | uniprot |
| Irs1 | uniprot |
| Il4 | uniprot |
| Il4ra | uniprot |
| Il13ra1 | uniprot |
| Jak2 | uniprot |
| TYK2 | uniprot |
| Jak1 | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Prkcz | uniprot |
| Stat6 | uniprot |
| Pawr | uniprot |
| Irs2 | uniprot |
| Jak3 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Cxcr4 | uniprot |
| Adrbk2 | uniprot |
| Ptk2 | uniprot |
| Shc1 | uniprot |
| Plcg1 | uniprot |
| HIST2H3C | uniprot |
| Crebbp | uniprot |
| Ep300 | |
| Mapk14 | uniprot |
| MAPK11 | uniprot |
| Atf2 | uniprot |
| RGD1561386 | |
| Stat6 | uniprot |
| Stat6 | uniprot |
| Stat5a | uniprot |
| RGD1564914 | |
| Stat6 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Mapk14 | uniprot |
| Dok2 | uniprot |
| Rasa1 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Bad | |
| NCF1 | uniprot |
| PIK3CA | uniprot |
| Pik3cd | uniprot |
| Bcl2l1 | uniprot |
| Socs1 | uniprot |
| Rps6kb1 | uniprot |
| Hmga1 | uniprot |
| Ets1 | uniprot |
| Socs3 | uniprot |
| Stat1 | uniprot |
| Src | uniprot |
| Elk1 | uniprot |
| Akt1 | uniprot |
| Prkcd | uniprot |
| Prkcn | uniprot |
| Prkci | uniprot |
| Prkcd | uniprot |
| Prkcn | uniprot |
| Prkci | uniprot |
| Prkcz | uniprot |
| Nfkb1 | uniprot |
| Sfpi1 | uniprot |
| Lck_mapped | |
| Fyn | uniprot |
| RGD1564499 | |
| Stat6 | uniprot |
| Jak2 | uniprot |
| Gene Symbol | |
| Translocation | |
| Cytoplasm | |
| Plasma membrane | |
| Nucleus | CHEBI:33252 |
| CY -> NU | |
| D | |
| D | |
| D | |
| D | |
| CY -> PM | |
| CY -> PM | |
| CY -> PM | |
| CY -> PM | |
| CY -> NU | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| D | |
| Inhibition | chemical |
| D | |
| Accession Number: NetPath_16 | |
| Proteins in a complex interaction | |
| Molecular association | |
| Reaction through unknown mechanisms/molecules | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Activation | chemical |
| (Protein-protein interaction) | |
| Acetylation | chemical |
| PM | |
| CY | |
| NU | |
| Enzyme complex | |
| Autophosphorylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Control |
| Il5 | uniprot |
| Il5 | uniprot |
| Il5ra | uniprot |
| Csf2rb1 | uniprot |
| Shc1 | uniprot |
| Ptpn11 | uniprot |
| Csf2rb1 | uniprot |
| Dnm2 | uniprot |
| Prkcb1 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| SHC2 | uniprot |
| Mapk14 | uniprot |
| Nfkbia | uniprot |
| Ptk2b | uniprot |
| Pik3cg | uniprot |
| Map2k2 | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Ptpn6 | uniprot |
| Nfkb1 | uniprot |
| Mapk9 | uniprot |
| Grb2 | uniprot |
| Lyn | |
| Unc119 | uniprot |
| Crkl | uniprot |
| Raf1 | uniprot |
| Kras | uniprot |
| Syk | uniprot |
| Sdcbp | uniprot |
| Sox4 | uniprot |
| Socs1 | uniprot |
| Ywhaz | uniprot |
| Hck | uniprot |
| Akt1 | uniprot |
| Rps6ka1 | uniprot |
| Foxo3a | |
| Nfkb1 | uniprot |
| Gsk3a | uniprot |
| Pla2g4a | uniprot |
| Vav1 | uniprot |
| Hcls1 | uniprot |
| RGD1561386 | |
| Aps | uniprot |
| Jun | uniprot |
| Btk | uniprot |
| Gsk3b | uniprot |
| Atf2 | uniprot |
| Elk1 | uniprot |
| IL2RB | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Crkl | uniprot |
| Alox5 | uniprot |
| Alox5 | uniprot |
| Bax | uniprot |
| Bax | uniprot |
| Prkcd | uniprot |
| Prkcd | uniprot |
| Il5ra | uniprot |
| Csf2rb1 | uniprot |
| Ctnnb1 | uniprot |
| Ctnnb1 | uniprot |
| Hras | uniprot |
| Rap1ga1 | |
| Ccnd3 | uniprot |
| Cdkn1b | uniprot |
| Rapgef1 | chemical |
| Alox5ap | uniprot |
| Rac1 | uniprot |
| Icam1 | uniprot |
| ICAM3 | uniprot |
| Itgb2 | uniprot |
| Itgam | uniprot |
| Pim1 | uniprot |
| Jak1 | uniprot |
| Jak2 | uniprot |
| Stat3 | uniprot |
| Stat1 | uniprot |
| Stat5b | uniprot |
| Stat5a | uniprot |
| (Protein-protein interaction) | |
| Translocation | |
| Autophosphorylation | chemical |
| Recruitment | |
| Inhibition | chemical |
| Activation | chemical |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Plasma membrane | |
| Control | |
| Ubiquitination | |
| Mitochondria | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->MT | |
| CY->PM | |
| PM->NU | |
| PM->NU | |
| PM->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| Gene Symbol | |
| D | |
| Accession Number: NetPath_17 | |
| Molecular association | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| PM | |
| CY | |
| NU | |
| MT | |
| D | |
| D | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Extracellular | |
| EC | |
| Endosome | |
| EN | |
| Endoplasmic reticulum | |
| ER | |
| Golgi apparatus | |
| GO |
| Il6 | uniprot |
| Il6ra | uniprot |
| Il6ra | uniprot |
| Il6st | uniprot |
| Il6st | uniprot |
| RGD1564385 | |
| Tec | uniprot |
| Btk | uniprot |
| Jak2 | uniprot |
| Ptpn11 | uniprot |
| Jak1 | uniprot |
| TYK2 | uniprot |
| Shc1 | uniprot |
| Grb2 | uniprot |
| Stat3 | uniprot |
| Sos1 | uniprot |
| Vav1 | uniprot |
| Mapk1 | uniprot |
| Gab1 | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Stat1 | uniprot |
| Stat1 | uniprot |
| Stat1 | uniprot |
| Stat3 | uniprot |
| Stat1 | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Mapk14 | uniprot |
| Mapk14 | uniprot |
| Sgk | uniprot |
| Sgk | uniprot |
| Nfkb1 | uniprot |
| Nfkb1 | uniprot |
| RGD1561602 | |
| Hras | uniprot |
| Ncoa1 | uniprot |
| Crebbp | uniprot |
| Rac1 | uniprot |
| Cdk9 | uniprot |
| Daxx | uniprot |
| Ar | |
| Hdac1 | uniprot |
| Prkcd | uniprot |
| Ptk2b | uniprot |
| Gab2 | uniprot |
| Map2k4 | uniprot |
| Hspca | uniprot |
| Socs3 | uniprot |
| Fos | uniprot |
| Jun | uniprot |
| Tcf1 | uniprot |
| Cebpb | uniprot |
| Erbb2 | uniprot |
| Erbb3 | uniprot |
| Hck | uniprot |
| Lyn | |
| Cebpb | uniprot |
| Raf1 | uniprot |
| Casp3 | uniprot |
| Casp9 | |
| Ppp2ca | uniprot |
| Ppp2cb | uniprot |
| Ppp2r1a | uniprot |
| Ppp2r1b | uniprot |
| Ppp2r2a | uniprot |
| Ppp2r2b | uniprot |
| Ppp2r2c | uniprot |
| Ppp2r3a | uniprot |
| PPP2R3B | uniprot |
| Ppp2r4 | uniprot |
| Ppp2r5a | uniprot |
| Ppp2r5b | |
| PPP2R5C | uniprot |
| Ppp2r5d | |
| Ppp2r5e | uniprot |
| Ep300 | |
| Map2k6 | uniprot |
| Cdk5 | uniprot |
| MAPT | uniprot |
| Rps6ka2 | uniprot |
| Mapk3 | uniprot |
| Fgr | uniprot |
| Plcg1 | uniprot |
| Map3k4 | uniprot |
| Rb1 | uniprot |
| Akt1 | uniprot |
| Bad | |
| Gsk3b | uniprot |
| Foxo1a | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Eif4e | uniprot |
| Eif2a | uniprot |
| Mapk8 | uniprot |
| Ptk2 | uniprot |
| Pxn | uniprot |
| Foxo3a | |
| RGD1561201 | |
| Inpp5d | |
| Inppl1 | |
| Rps6kb1 | uniprot |
| Eif4ebp1 | uniprot |
| RGD1565643 | |
| Fyn | uniprot |
| Tnfrsf5 | uniprot |
| Stat3 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Mapkapk2 | uniprot |
| Map3k7 | uniprot |
| Map3k7 | uniprot |
| Hspb1 | uniprot |
| Il6 | uniprot |
| Cdk5r1 | uniprot |
| Autophosphorylation | chemical |
| Early Endosomes | |
| Inhibition | chemical |
| Translocation | |
| Cytoplasm | |
| CY->NU | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Acetylation | chemical |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| D | |
| CY->EN | |
| CY->NU | |
| CY->NU | |
| D | |
| D | |
| D | |
| D | |
| D | |
| Ligand | |
| Receptor | |
| Molecule in the pathway | |
| CY->NU | |
| Activation | chemical |
| Complex formation | |
| Gene Symbol | |
| D | |
| D | |
| Accession Number: NetPath_18 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-Protein interaction) | |
| D | |
| Reactions through unknown mechanisms/molecules | |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| CY | |
| Extracellular | |
| EC | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| NU | |
| Nucleus | CHEBI:33252 |
| PM | |
| Plasma membrane | |
| Molecular association |
| Pik3r1 | uniprot |
| Il7r | uniprot |
| Jak3 | uniprot |
| Il2rg | uniprot |
| Jak1 | uniprot |
| Fyn | uniprot |
| Lyn | |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Stat3 | uniprot |
| Pik3r1 | uniprot |
| Ptk2b | uniprot |
| Irs1 | uniprot |
| Irs2 | uniprot |
| Akt1 | uniprot |
| Stat1 | uniprot |
| Stam2 | uniprot |
| RGD1564499 | |
| Bax | uniprot |
| Bad | |
| Foxo3a | |
| Gsk3b | uniprot |
| Foxo1a | uniprot |
| Rb1 | uniprot |
| Ccnd2 | uniprot |
| Ccna2 | uniprot |
| Cdk4 | uniprot |
| CDK2 | uniprot |
| Cltc | uniprot |
| Bcl2l11 | uniprot |
| Mcl1 | uniprot |
| Blk | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Cblb | uniprot |
| Shc1 | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| RGD1561386 | |
| Irf1 | uniprot |
| Muc1 | uniprot |
| Gene Symbol | |
| Hras | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| D | |
| D | |
| D | |
| PM | |
| CY | |
| NU | |
| EN | |
| GO | |
| MT | |
| Plasma membrane | |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| Molecular association | |
| Reaction through unknown mechanisms/molecules | |
| Phosphorylation | chemical |
| Autophosphorylation | chemical |
| Dephosphorylation | chemical |
| Palmitoylation | chemical |
| Ubiquitination | |
| Proteolytic cleavage | |
| Glycosylation | |
| Acetylation | chemical |
| Sumoylation | chemical |
| Methylation | chemical |
| Recruitment | |
| Activation | chemical |
| Inhibition | chemical |
| Translocation | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Endosome | |
| Golgi apparatus | |
| Mitochondrion | |
| Accession Number: NetPath_19 | |
| EC | |
| Extracellular | |
| Deacetylation | chemical |
| Demethylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Control |
| Il9 | uniprot |
| Il9r | uniprot |
| Il2rg | uniprot |
| Irs1 | uniprot |
| Pik3r1 | uniprot |
| Irs2 | uniprot |
| Grb2 | uniprot |
| Htatip | uniprot |
| Stat3 | uniprot |
| Stat3 | uniprot |
| Jak1 | uniprot |
| Vcp | uniprot |
| Jak3 | uniprot |
| Map2k2 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Map2k1 | uniprot |
| Shc1 | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Akt1 | uniprot |
| Ptpn11 | uniprot |
| TYK2 | uniprot |
| Socs3 | uniprot |
| Molecular association | |
| CY->NU | |
| Translocation | |
| CY | |
| NU | |
| Autophosphorylation | chemical |
| Phosphorylation | chemical |
| D | |
| Reaction through unknown mechanisms/molecules | |
| D | |
| D | |
| D | |
| Inhibition | chemical |
| Receptor | |
| Ligand | |
| Activation | chemical |
| Accession Number: NetPath_20 | |
| Gene Symbol | |
| Molecule in the pathway | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Proteins in a complex interaction | |
| Proteins in a complex interaction | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| PM | |
| Plasma membrane | |
| (Protein-protein interaction) |
| Tnfsf5 | uniprot |
| RGD:619830 | |
| Zap70 | uniprot |
| Il2ra | uniprot |
| Il2rb | uniprot |
| Il2rg | uniprot |
| Il5ra | uniprot |
| Il4r | uniprot |
| Cd80 | uniprot |
| Cd86 | uniprot |
| Cd28 | uniprot |
| Il2 | uniprot |
| Il4 | uniprot |
| Ifng | uniprot |
| Tnfrsf1a | uniprot |
| Tnfrsf1b | uniprot |
| Tnf | uniprot |
| Lta | uniprot |
| Il1a | uniprot |
| Il1b | uniprot |
| Il6 | uniprot |
| Fn1 | uniprot |
| Lama5 | uniprot |
| Lamb2 | uniprot |
| Lamc2 | uniprot |
| Lamc1 | uniprot |
| Vtn | uniprot |
| Il10ra | uniprot |
| Mmp2 | uniprot |
| Col3a1 | uniprot |
| Col1a2 | uniprot |
| Col1a1 | uniprot |
| Fcgr1 | uniprot |
| H2-Eb1 | uniprot |
| Lamb1-1 | uniprot |
| Thbs1 | uniprot |
| Thbs3 | uniprot |
| Il5 | uniprot |
| Igha | chemical |
| Fcamr | |
| Lck | uniprot |
| Fibroblast | |
| Blood or Lymph | |
| Epithelium | |
| Inflammation | |
| Early Response | |
| Fibrotic Response | |
| TH-cell | |
| Macrophage | |
| B-cell |
| Insr | uniprot | |
| Igf1r | uniprot | |
| Irs1 | uniprot | |
| Irs2 | uniprot | |
| IRS-4 | ||
| Pik3ca | uniprot | |
| Pik3cb | uniprot | |
| Pik3cg | uniprot | |
| Pik3cd | uniprot | |
| Pik3r1 | uniprot | |
| Pik3r2 | uniprot | |
| Pik3r3 | uniprot | |
| Pik3r4 | uniprot | |
| Pik3c2a | uniprot | |
| Pik3c3 | uniprot | |
| Pik3c2g | uniprot | |
| Pdpk1 | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Gsk3b | uniprot | |
| Gsk3a | uniprot | |
| Slc2a4 | uniprot | |
| Pten | uniprot | |
| Hint1 | uniprot | |
| Prkcz | uniprot | |
| Pscd3 | uniprot | |
| Arf6 | uniprot | |
| Arf1 | uniprot | |
| Inpp4a | uniprot | |
| Trib3 | uniprot | |
| Foxo1a | uniprot | |
| Pfkm | uniprot | |
| Gys1 | uniprot | |
| Gab1 | uniprot | |
| Shc1 | uniprot | |
| Shc2 | uniprot | |
| Grb2 | uniprot | |
| Ptpn11 | uniprot | |
| Sos2 | uniprot | |
| Raf1 | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Map2k3 | uniprot | |
| Map2k4 | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Map3k1 | uniprot | |
| Map3k2 | uniprot | |
| Map3k3 | uniprot | |
| Map3k4 | uniprot | |
| Mapk3 | uniprot | |
| Mapk4 | uniprot | |
| Mapk1 | uniprot | |
| Mapk6 | uniprot | |
| Mapk13 | uniprot | |
| Mapk9 | uniprot | |
| Mapk10 | uniprot | |
| Map4k1 | uniprot | |
| Map3k5 | uniprot | |
| Map3k10 | ||
| Mapk8 | uniprot | |
| Mapk14 | uniprot | |
| Map3k8 | uniprot | |
| Map3k12 | uniprot | |
| Map4k2 | uniprot | |
| Map3k7 | uniprot | |
| Map3k11 | ||
| Map2k7 | ||
| Mapk11 | uniprot | |
| Map3k9 | ||
| Map4k4 | uniprot | |
| Mapk7 | uniprot | |
| Map3k13 | ||
| Map4k3 | uniprot | |
| Map3k6 | ||
| LOC303259 | ||
| Mapk12 | uniprot | |
| Map4k5 | uniprot | |
| Map3k14 | uniprot | |
| Rps6kb1 | uniprot | |
| Rps6ka2 | uniprot | |
| Rps6kb2 | uniprot | |
| Rps6ka1 | uniprot | |
| Rps6ka5 | uniprot | |
| LOC317203 | ||
| Rps6ka4 | uniprot | |
| Irs3 | chemical | |
| Ppp1cc | uniprot | |
| Ptprf | ||
| Cbl | uniprot | |
| Cblb | uniprot | |
| Cblc | uniprot | |
| Rapgef1 | chemical | |
| Cap1 | uniprot | |
| Sorbs1 | uniprot | |
| Rhoj | uniprot | |
| Snx26 | uniprot | |
| Rhoq | uniprot | |
| Crk | uniprot | |
| Flot1 | uniprot | |
| Flot2 | uniprot | |
| Aps | uniprot | |
| Ptpn1 | uniprot | |
| Frap1 | uniprot | |
| Eif4e | uniprot | |
| Eif4ebp1 | uniprot | |
| Lipe | uniprot | |
| Gys2 | uniprot | |
| Egr1 | uniprot | |
| Fos | uniprot | |
| Jun | uniprot | |
| Slc2a1 | uniprot | |
| Grb10 | uniprot | |
| Shc3 | uniprot | |
| Hras | uniprot | |
| Rrad | uniprot | |
| Inppl1 | ||
| Prkca | uniprot | |
| Prkcb1 | uniprot | |
| PRKCQ | uniprot | |
| Prkch | uniprot | |
| Prkcd | uniprot | |
| Enpp1 | uniprot | |
| Gyg1 | uniprot | |
| Pfkl | uniprot | |
| Tsc1 | uniprot | |
| Rheb | uniprot | |
| Tsc2 | uniprot | |
| Rab4a | uniprot | |
| Stxbp4 | uniprot | |
| Vamp2 | uniprot | |
| Snap25 | uniprot | |
| Snap23 | uniprot | |
| Ehd1 | uniprot | |
| Ehd3 | uniprot | |
| Myo1c | uniprot | |
| Kif5b | uniprot | |
| Kif3a | uniprot | |
| Sgk | uniprot | |
| Sgk2 | uniprot | |
| Sgkl | uniprot | |
| Foxo3a | ||
| Tbc1d4 | uniprot | |
| Kcnh8 | uniprot | |
| Srf | uniprot | |
| Grb14 | uniprot | |
| Stxbp1 | uniprot | |
| Stxbp2 | uniprot | |
| Stxbp3 | uniprot | |
| Stx4a | uniprot | |
| Mapk8 | uniprot | |
| Socs1 | uniprot | |
| Socs3 | uniprot | |
| Prkaa1 | uniprot | |
| Prkaa2 | uniprot | |
| Ikbkb | uniprot | |
| RGD:1303073 | ||
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Rps6ka3 | uniprot | |
| Glucose Transport | ||
| Modulators of Insulin Action | ||
| MEK/MAP Kinases | ||
| Insulin Receptor Substrates | ||
| PI 3-Kinase | ||
| p90 Rsk Kinases | ||
| Transcriptional Regulators & Immediate Early Genes | ||
| Vesicular Trafficking | ||
| p70 S6 Kinases | ||
| Metabolic Regulation | ||
| Ras-MAPK Signaling | ||
| PDK/Akt Signaling | ||
| Tor Signaling | ||
| Translation Regulation |
| Cdc42 | uniprot | |
| Shc1 | uniprot | |
| Shc3 | uniprot | |
| Araf1 | uniprot | |
| Braf | uniprot | |
| Raf1 | uniprot | |
| Mapk4 | uniprot | |
| Mapk7 | uniprot | |
| Capns1 | uniprot | |
| Mylk2 | uniprot | |
| Arhgef7 | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Rac3 | uniprot | |
| Pdpk1 | uniprot | |
| Vav2 | uniprot | |
| Vav3 | uniprot | |
| Rock2 | uniprot | |
| Rock1 | uniprot | |
| SH3D5 | uniprot | |
| Sos2 | uniprot | |
| MGC94099 | ||
| Pik3r2 | uniprot | |
| Zyx | uniprot | |
| Cav1 | uniprot | |
| RGD:620348 | ||
| Cav3 | uniprot | |
| Fyn | uniprot | |
| Grb2 | uniprot | |
| Sepp1 | uniprot | |
| Ha-Ras | uniprot | |
| Ptk2 | uniprot | |
| Ptk2 | uniprot | |
| Ilk | uniprot | |
| p110 | uniprot | |
| Rho | uniprot | |
| PI5K | ||
| Csk | uniprot | |
| Bcar1 | uniprot | |
| Src | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| MYO-P | ||
| MYO | ||
| Capn2 | uniprot | |
| Capn3 | uniprot | |
| Capn5 | uniprot | |
| Capn7 | uniprot | |
| Capn9 | uniprot | |
| Capn10 | uniprot | |
| RGD:1302946 | ||
| Capn6 | uniprot | |
| Pak1 | uniprot | |
| Pak2 | uniprot | |
| Pak3 | uniprot | |
| Pak4 | uniprot | |
| Pak6 | ||
| Vasp | uniprot | |
| ACTN | ||
| Tln | uniprot | |
| Map2k3 | uniprot | |
| Map2k5 | uniprot | |
| Map2k6 | uniprot | |
| Mapk12 | uniprot | |
| Akt3 | uniprot | |
| Dock1 | uniprot | |
| Crk | uniprot | |
| Rapgef1 | chemical | |
| RAP-1A | ||
| Rap1b | uniprot | |
| Mapk1 | uniprot | |
| Mapk6 | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Capn1 | uniprot | |
| Itga1 | uniprot | |
| Itga2 | uniprot | |
| Itga3 | uniprot | |
| Itga4 | uniprot | |
| Itga5 | uniprot | |
| Itga6 | uniprot | |
| Itga7 | uniprot | |
| Itga8 | ||
| Itga9 | ||
| Itga10 | ||
| Itga11 | uniprot | |
| Itga2b | uniprot | |
| Itgae | uniprot | |
| ITGAD | uniprot | |
| Itgal | uniprot | |
| Itgam | uniprot | |
| Itgav | uniprot | |
| Itgax | uniprot | |
| Itgb1 | uniprot | |
| Itgb2 | uniprot | |
| Itgb3 | uniprot | |
| Itgb4 | uniprot | |
| Itgb5 | uniprot | |
| RGD:1303119 | ||
| Itgb7 | uniprot | |
| Itgb8 | ||
| Src | uniprot | |
| Vcl | uniprot | |
| Tns | ||
| Mapk10 | uniprot | |
| Pxn | uniprot | |
| CAPN | uniprot | |
| PI3K | uniprot | |
| Phosphatidylinositiol | chemical | |
| signaling system | ||
| C3G | uniprot | |
| F-actin | chemical | |
| p130 Cas | ||
| MEK | hmdbid:HMDB00474 | |
| ERK | enzyme | uniprot |
| PAK | ||
| cell proliferation | ||
| F-actin | chemical | |
| cell motility | ||
| cell maintenance | ||
| cell maintenance | ||
| RAF | ||
| CAPN | uniprot | |
| PAK | ||
| ECM | uniprot | |
| Integrin alpha | ||
| Integrin beta | ||
| ITGA | ||
| ITGB |
| Ces2 | uniprot |
| RGD:621508 | |
| Irinotecan | chemical |
| SN-38 | |
| CYP3A4 | uniprot |
| CYP3A5 | uniprot |
| M4 | |
| APC | uniprot |
| NPC | uniprot |
| CYP3A4 | uniprot |
| CYP3A5 | uniprot |
| CYP3A4 | uniprot |
| RGD:621508 | |
| Ces2 | uniprot |
| SN-38 | |
| Ugt1a1 | uniprot |
| UGT1A9 | uniprot |
| Abcc1 | uniprot |
| Abcc2 | uniprot |
| SN-38 | |
| RGD:621508 | |
| Ces2 | uniprot |
| Abcc1 | uniprot |
| Abcc2 | uniprot |
| Abcg2 | uniprot |
| Ugt1a6 | uniprot |
| Ugt1a1 | uniprot |
| UGT1A10 | uniprot |
| SN-38G | |
| Ces2 | uniprot |
| RGD:621508 | |
| Bche | uniprot |
| Abcc2 | uniprot |
| Ugt1a6 | uniprot |
| Abcc1 | uniprot |
| SN-38 | |
| Irinotecan | chemical |
| Irinotecan | chemical |
| Neutropenia | |
| Liver Cell | |
| Diarrhea | |
| Intestine | |
| Model human liver cell showing blood, bile and | |
| intestinal compartments, indicating tissue | |
| involvment of genes in the irinotecan pathway. |
| Grb7 | uniprot |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| Shc1 | uniprot |
| Csf2rb1 | uniprot |
| Grb2 | uniprot |
| Socs6 | uniprot |
| Socs4 | uniprot |
| RGD1564914 | |
| Cish | uniprot |
| Cltc | uniprot |
| Crk | uniprot |
| Src | uniprot |
| Plce1 | uniprot |
| Jak2 | uniprot |
| Grap | uniprot |
| Ptpru | |
| RGD1311584 | |
| Prkca | uniprot |
| Plcg1 | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| Pik3cg | uniprot |
| Aps | uniprot |
| RGD1566234 | |
| Akt1 | uniprot |
| Tec | uniprot |
| Lyn | |
| Dok1 | uniprot |
| Ptpn6 | uniprot |
| Ptpn11 | uniprot |
| Epor | uniprot |
| Rps6ka1 | uniprot |
| Mitf | uniprot |
| Mapk1 | uniprot |
| Abl1_mapped | |
| Inpp5d | |
| Fgr | uniprot |
| Hck | uniprot |
| Yes1 | uniprot |
| Rasa1 | uniprot |
| RGD1564385 | |
| Crkl | uniprot |
| RGD1561386 | |
| Socs1 | uniprot |
| Vav1 | uniprot |
| Vav2 | uniprot |
| Matk | uniprot |
| Bad | |
| Sos1 | uniprot |
| Ep300 | |
| Fyn | uniprot |
| Prkcb1 | uniprot |
| Hras | uniprot |
| Raf1 | uniprot |
| Spred2 | uniprot |
| Spred1 | uniprot |
| Sh3kbp1 | uniprot |
| Cblb | uniprot |
| Tnfrsf10b | uniprot |
| Btk | uniprot |
| Kit | |
| Kitl | uniprot |
| Kit | |
| Kitl | uniprot |
| Map2k1 | uniprot |
| Stat3 | uniprot |
| Mpdz | uniprot |
| Dok1 | uniprot |
| p85 complex | |
| Molecular association | |
| Phosphorylation | chemical |
| Activation | chemical |
| Inhibition | chemical |
| Autophosphorlation | |
| Dephosphorylation | chemical |
| Plasma Membrane | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| CY->PM | |
| Accession Number: NetPath_6; cellmap:6 | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| (Protein-protein interaction) | |
| D | |
| PM | |
| CY | |
| NU | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Ubiquitination | |
| Deubiquitination | |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondrion | |
| Translocation | |
| Desumoylation |
| RGD:735073 | ||
| Suclg1 | uniprot | |
| Mdh1 | uniprot | |
| Pc | ||
| Mor1 | uniprot | |
| Fh1 | uniprot | |
| Sdha | uniprot | |
| Sdhd | uniprot | |
| Pdha1 | uniprot | |
| Pdha2 | uniprot | |
| Dlat | uniprot | |
| Cs | ||
| Idh3a | uniprot | |
| Idh3B | uniprot | |
| Idh3g | uniprot | |
| RGD:708561 | ||
| Aco2 | uniprot | |
| Pdk2 | uniprot | |
| Pdk4 | uniprot | |
| Pdk3 | uniprot | |
| Sdhb | uniprot | |
| Sdhc | uniprot | |
| Sucla2 | uniprot | |
| Suclg2 | uniprot | |
| Idh2 | uniprot | |
| Ogdh | uniprot | |
| Pdhx | uniprot | |
| Dld | uniprot | |
| Pdhb | uniprot | |
| Pdb | ||
| Pyruvate | hmdbid:HMDB00243 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Succinate | hmdbid:HMDB00254 | |
| Malate | hmdbid:HMDB03256 | |
| alpha-Ketogluterate | chemical | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Fumarate | hmdbid:HMDB00134 | |
| Malate | hmdbid:HMDB03256 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| Isocitrate | hmdbid:HMDB00193 | |
| Fatty Acid Synthesis | ||
| Glycolysis | ||
| Gluconeogenesis | chemical | |
| Degradation of Fatty Acids | ||
| Containing an Odd Number of Carbons | ||
| Electron Transport Chain | ||
| Degradation of Fatty Acids | ||
| Containing an Even Number of Carbons | ||
| Citrate | hmdbid:HMDB00094 | |
| Succinyl-CoA | hmdbid:HMDB01022 | |
| Mitochondrion | ||
| Cytosol |
| Sipa1l1 | uniprot |
| Hras1 | uniprot |
| Nras1 | |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Mapk3 | uniprot |
| Mbp | uniprot |
| Mtap2 | uniprot |
| Map3k1 | uniprot |
| Mapk10 | uniprot |
| Mapk14 | uniprot |
| Jun | uniprot |
| RapGAPII | chemical |
| Map3k2 | uniprot |
| MEKK3 | uniprot |
| Rasa3 | uniprot |
| Plcb3 | uniprot |
| Mapk1 | uniprot |
| Kcnh8 | uniprot |
| Araf1 | uniprot |
| Raf1 | uniprot |
| Braf | uniprot |
| Kras2 | uniprot |
| Rras | uniprot |
| MKK3 | uniprot |
| Map2k6 | uniprot |
| JNKK 1 | uniprot |
| MKK7 | uniprot |
| Map3k12 | uniprot |
| Mapk12 | uniprot |
| GDP | hmdbid:HMDB01201 |
| Activated | |
| GTP | hmdbid:HMDB01273 |
| G | |
| i | |
| G | |
| q | |
| and G | |
| g | |
| b | |
| G | |
| Stress Activated Pathways | |
| p38 MAPK Pathway | |
| Growth and Mitogenesis | |
| Apoptosis | |
| Nucleus | CHEBI:33252 |
| Rap1GAP | uniprot |
| Pr1 | uniprot | |
| Ntrk1 | uniprot | |
| Egfr | uniprot | |
| fgfr | ||
| Pdgfrb | uniprot | |
| Ngfb | uniprot | |
| Bdnf | uniprot | |
| Ntf5 | uniprot | |
| Egf | uniprot | |
| Fgf4 | uniprot | |
| Pdgfb | uniprot | |
| Grb2 | uniprot | |
| Sos2 | uniprot | |
| Kras2 | uniprot | |
| Nras | uniprot | |
| Mras | uniprot | |
| Gna12 | uniprot | |
| Gap1m | ||
| Rasgrf2 | ||
| Rasgrp4 | ||
| Rasgrp1 | ||
| Nf1 | uniprot | |
| Rasa1 | uniprot | |
| Prkcd | uniprot | |
| Prkcc | uniprot | |
| Prkcb1 | uniprot | |
| Prkcz | uniprot | |
| Prkch | uniprot | |
| Prkcd | uniprot | |
| Il1r2 | uniprot | |
| Il1r1 | uniprot | |
| RGD:619831 | ||
| Acvr1c | uniprot | |
| Acvr1b | uniprot | |
| Tgfbr1 | uniprot | |
| Tgfbr2 | uniprot | |
| Cd14 | uniprot | |
| Tnf | uniprot | |
| Il1a | uniprot | |
| Il1b | uniprot | |
| Tnfsf6 | uniprot | |
| Tgfb3 | uniprot | |
| Tgfb1 | uniprot | |
| Tgfb2 | uniprot | |
| Gadd45a | uniprot | |
| traf6 | uniprot | |
| tab2 | uniprot | |
| ecsit | chemical | |
| Daxx | uniprot | |
| tab1 | uniprot | |
| traf2 | uniprot | |
| Casp1 | uniprot | |
| Casp3 | uniprot | |
| Casp9 | ||
| Casp7 | uniprot | |
| Casp8 | uniprot | |
| Casp2 | uniprot | |
| Casp6 | uniprot | |
| Rac1 | uniprot | |
| Rac2 | uniprot | |
| Cdc42 | uniprot | |
| Braf | uniprot | |
| Raf1 | uniprot | |
| Mos | uniprot | |
| Prkaca | uniprot | |
| Rap1b | uniprot | |
| RAP-1A | ||
| Map4k3 | uniprot | |
| hgk | ||
| hpk1 | uniprot | |
| Pak1 | uniprot | |
| Pak2 | uniprot | |
| Stk3 | uniprot | |
| mink | ||
| gck | uniprot | |
| Map3k8 | uniprot | |
| Map3k1 | uniprot | |
| mlk3 | ||
| Map3k2 | uniprot | |
| lzk | ||
| Map3k12 | uniprot | |
| mltk | uniprot | |
| ask2 | ||
| Map3k5 | uniprot | |
| Map3k7 | uniprot | |
| mekk4 | uniprot | |
| RGD:708455 | ||
| Taok2 | uniprot | |
| Ppm1b | uniprot | |
| Map2k5 | uniprot | |
| Mapk7 | uniprot | |
| Map2k1 | uniprot | |
| Map2k2 | uniprot | |
| Mapk1 | uniprot | |
| Mapk3 | uniprot | |
| Mapk4 | uniprot | |
| Mapk6 | uniprot | |
| mp1 | uniprot | |
| RGD:708516 | ||
| Ptpn5 | uniprot | |
| Ptprr | uniprot | |
| Dusp1 | uniprot | |
| Dusp6 | uniprot | |
| Dusp5 | uniprot | |
| Dusp7 | uniprot | |
| Dusp4 | uniprot | |
| Dusp10 | uniprot | |
| nik | uniprot | |
| RGD:735223 | ||
| Ikbkb | uniprot | |
| Akt1 | uniprot | |
| Akt2 | uniprot | |
| Akt3 | uniprot | |
| Ppp5c | uniprot | |
| mkk3 | uniprot | |
| Map2k6 | uniprot | |
| Ppm1a | uniprot | |
| Mapk13 | uniprot | |
| Mapk12 | uniprot | |
| Mapk14 | uniprot | |
| Nfkb1 | uniprot | |
| Mapt | uniprot | |
| Stmn1 | uniprot | |
| Pla2g5 | uniprot | |
| Pla2g10 | uniprot | |
| mnk1/2 | ||
| rsk2 | uniprot | |
| Atf4 | uniprot | |
| elk-1 | chemical | |
| Sap1a | chemical | |
| Myc | uniprot | |
| SRF | uniprot | |
| Fos | uniprot | |
| RGD:621616 | ||
| Ppp3ca | uniprot | |
| Ppp3cb | uniprot | |
| Ppp3r1 | uniprot | |
| Ppp3r2 | uniprot | |
| mkk7 | ||
| mkk4 | ||
| Mapk8 | uniprot | |
| Mapk10 | uniprot | |
| Mapk9 | uniprot | |
| Mapk8ip | uniprot | |
| RGD:708516 | ||
| Ptpn5 | uniprot | |
| Ptprr | uniprot | |
| flna | uniprot | |
| JSAP1 | uniprot | |
| Arrb1 | uniprot | |
| Arrb2 | uniprot | |
| Crk | uniprot | |
| Crkl | uniprot | |
| Hspa8 | uniprot | |
| Hspa1a | uniprot | |
| Hspa5 | uniprot | |
| Jun | uniprot | |
| Jund | uniprot | |
| nfat2/4 | ||
| Atf2 | uniprot | |
| Elk-1 | chemical | |
| Tp53 | uniprot | |
| sap1a | chemical | |
| Ddit3 | uniprot | |
| Max | ||
| mef2c | uniprot | |
| Hspb2 | uniprot | |
| Hspb1 | uniprot | |
| Atf4 | uniprot | |
| Nr4a1 | uniprot | |
| prak | ||
| Mapkapk2 | uniprot | |
| msk1/2 | ||
| Cdc25b | uniprot | |
| nlk | uniprot | |
| Classical MAP kinase Pathway | ||
| Ca2+ | CHEBI:29108 | |
| DAG | uniprot | |
| LPS | CHEBI:16412 | |
| DNA damage | ||
| JNK & p38 MAP kinase pathway | ||
| Serum, cytotoxic drugs, irradiation, | ||
| heatshock, reactive oxy species | ||
| LPS and other stress | ||
| Integrin-mediated | ||
| cell adhesion | ||
| cAMP | hmdbid:HMDB00058 | |
| IP3 | ||
| Heteromeric G-protein | ||
| Phosphatidylinositol | chemical | |
| signaling system | ||
| MAPKKKK | ||
| ERK5 pathway | ||
| Serum, EGF, | ||
| reactive oxygen species, | ||
| or Srk tyrosinkinase | ||
| downstream | ||
| PTP | uniprot | |
| MKP | ||
| p38 | uniprot | |
| Proliferation, inflammation, anti-apoptosis | ||
| DNA | CHEBI:16991 | |
| DNA | CHEBI:16991 | |
| Proliferation, | ||
| differentiation | ||
| JNK | enzyme | uniprot |
| PTP | uniprot | |
| MAPKKK | enzyme | uniprot |
| MAPKK | enzyme | uniprot |
| MAPK | enzyme | uniprot |
| Transcription factors | ||
| DNA | CHEBI:16991 | |
| Alzheimer’s disease | ||
| Wnt signaling | ||
| DNA | CHEBI:16991 | |
| Apoptosis | ||
| Proliferation, differentiation, | ||
| inflammation | ||
| DNA | CHEBI:16991 | |
| Proliferation, differentiation | ||
| Cell | ||
| Cycle | ||
| pathway |
| RGD:631408 | |
| Mmp13 | uniprot |
| Mmp7 | uniprot |
| Mmp12 | uniprot |
| Mmp2 | uniprot |
| Mmp9 | uniprot |
| Timp1 | uniprot |
| Timp2 | uniprot |
| Timp3 | uniprot |
| Mmp3 | uniprot |
| Mmp10 | uniprot |
| Mmp11 | uniprot |
| Mmp23 | uniprot |
| Bsg | uniprot |
| Tnf | uniprot |
| Mmp14 | uniprot |
| Mmp16 | uniprot |
| Mmp24 | uniprot |
| Tcf20 | uniprot |
| Timp4 | uniprot |
| Mmp1 | uniprot |
| Mmp20 | uniprot |
| Mmp19 | uniprot |
| Mmp22 | |
| Mmp27 | |
| Mmp28 | |
| Mmp15 | uniprot |
| Mmp17 | uniprot |
| Mmp25 | |
| Gelatinases | |
| Collagenases | |
| Stromelysins | chemical |
| Membrane-type MMPs | |
| Matrilysin | enzyme |
| Inhibitors | |
| Enamelysin | uniprot |
| Other | |
| Potential Inducers of Transcription | |
| Metalloelastase | enzyme |
| Based on Vu & Werb (2000) | |
| Matrix metalloproteinases: effectors of | |
| development and normal physiology. | |
| Genes Dev 14:2123-2133 |
| Dci | uniprot | |
| Decr1 | uniprot | |
| Cpt1b | uniprot | |
| Acadl | uniprot | |
| Acadvl | uniprot | |
| Acsl5 | uniprot | |
| Acsl4 | uniprot | |
| Cpt1a | uniprot | |
| Acsl3 | uniprot | |
| Acsl6 | uniprot | |
| Hadhsc | uniprot | |
| Hadha | uniprot | |
| Acaa2 | uniprot | |
| Cpt2 | uniprot | |
| Acadm | uniprot | |
| Acads | uniprot | |
| Echs1 | uniprot | |
| Acsl1 | uniprot | |
| Slc25a20 | uniprot | |
| Long chain Acyl-CoA | ||
| trans- | chemical | |
| 3-Ketoacyl-CoA | chemical | |
| saturated | ||
| unsaturated | ||
| mitochondrial matrix | ||
| cytosol | ||
| -Enoyl-CoA | chemical | |
| Acyl-CoA (n-2) | ||
| 2,4 Dienoyl-CoA | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| D | ||
| 2 | ||
| Long Chain Fatty Acid | ||
| 3-L-Hydroxyacyl-CoA | chemical | |
| Long chain acyl-carnitine | ||
| Long chain acyl-carnitine | ||
| Acyl-CoA dehydrogenases: | ||
| cis- | chemical | |
| D- | ||
| -Enoyl-CoA | chemical | |
| 3 | ||
| Long chain Acyl-CoA |
| Drd1a | uniprot |
| Drd2 | uniprot |
| Drd3 | uniprot |
| Drd4 | uniprot |
| Htr2a | uniprot |
| Htr2b | uniprot |
| Htr4 | uniprot |
| Htr5a | uniprot |
| Htr5b | uniprot |
| Htr6 | uniprot |
| Htr7 | uniprot |
| Adra1a | uniprot |
| Adra1b | uniprot |
| Adra1d | uniprot |
| Adra2a | uniprot |
| Adra2b | uniprot |
| Adra2c | uniprot |
| Adrb2 | uniprot |
| Adrb3 | uniprot |
| Admr | uniprot |
| Chrm1 | uniprot |
| Chrm2 | uniprot |
| Chrm3 | uniprot |
| Chrm4 | uniprot |
| Chrm5 | uniprot |
| Adrb1 | uniprot |
| Drd5 | uniprot |
| Hrh1 | uniprot |
| Hrh2 | uniprot |
| Htr1a | uniprot |
| Htr1b | uniprot |
| Htr1d | uniprot |
| Htr1f | uniprot |
| Htr1e | |
| Htr1d | uniprot |
| Htr2c | uniprot |
| Dopamine | hmdbid:HMDB00073 |
| Adrenergic | |
| Serotonin | hmdbid:HMDB00259 |
| Gi/Go Pathway | |
| Gq/G11 Pathway | |
| Gs Pathway | |
| Gs Pathway | |
| Muscarinic | |
| Histamine | hmdbid:HMDB00870 |
| Acetylcholine Receptors | |
| Receptors | |
| Receptors | |
| Receptors | |
| Receptors |
| Hnrpa1 | uniprot | |
| Hnrpa2b1 | uniprot | |
| Hnrpab | uniprot | |
| Hnrpc | uniprot | |
| Hnrpk | uniprot | |
| Hnrpl | uniprot | |
| Fusip1 | uniprot | |
| Snrpd1 | uniprot | |
| Snrpd2 | uniprot | |
| Snrpe | uniprot | |
| Snrpf | uniprot | |
| SNRPG | uniprot | |
| Cstf1 | uniprot | |
| CSTF2 | uniprot | |
| Cpsf3 | uniprot | |
| Cpsf1 | uniprot | |
| Cpsf2 | uniprot | |
| Cstf2t | uniprot | |
| Pabpn1 | uniprot | |
| Sfrs9 | uniprot | |
| LSM2 | uniprot | |
| SFRS1 | uniprot | |
| SFRS2 | uniprot | |
| Sfrs3 | uniprot | |
| Sfrs5 | uniprot | |
| Srrm1 | uniprot | |
| Clk | uniprot | |
| Clk3 | uniprot | |
| CLK2 | uniprot | |
| Clk4 | uniprot | |
| U2af2 | uniprot | |
| Snrpn | uniprot | |
| Sfrs7 | uniprot | |
| SFRS6 | uniprot | |
| Sfrs10 | uniprot | |
| Polr2a | uniprot | |
| SUPT5H | uniprot | |
| Rnmt | uniprot | |
| Rngtt | uniprot | |
| Ncbp1 | uniprot | |
| Ncbp2 | uniprot | |
| Mettl3 | uniprot | |
| Hnrpa3 | uniprot | |
| Hnrpd | uniprot | |
| Rbmxrt | uniprot | |
| Hnrph1 | uniprot | |
| Hnrph2 | uniprot | |
| Hnrpr | ||
| Hnrpm | uniprot | |
| PTBP1 | uniprot | |
| U1 snRNA | ||
| U4 snRNA | ||
| U5 snRNA | ||
| Rnu6 | ||
| Snrp70 | uniprot | |
| Snrpa | uniprot | |
| RGD:621301 | ||
| Smc1l1 | uniprot | |
| Cd2bp2 | uniprot | |
| Nsep1 | uniprot | |
| Dhx9 | uniprot | |
| SNRPD3 | uniprot | |
| Sfrs14 | uniprot | |
| Tmp21 | uniprot | |
| AI450757 | ||
| SFRS16 | uniprot | |
| Fus | uniprot | |
| Sf4 | uniprot | |
| Rbm5 | uniprot | |
| Cpsf5 | uniprot | |
| Cpsf4 | uniprot | |
| Snrp116 | uniprot | |
| Txnl4 | uniprot | |
| Ssfa1 | uniprot | |
| Sf3b5 | uniprot | |
| SFRS4 | uniprot | |
| RNU2 | uniprot | |
| Snrpb2 | uniprot | |
| Sf3a3 | uniprot | |
| Snrpa1 | uniprot | |
| Sf3a1 | uniprot | |
| Sf3a2 | uniprot | |
| Sf3b1 | uniprot | |
| Sf3b2 | ||
| Sfb3 | ||
| Sf3b4 | ||
| Dhx38 | ||
| Cdc40 | uniprot | |
| Dnajc8 | uniprot | |
| Prpf8 | uniprot | |
| PHF5A | uniprot | |
| Prpf4 | uniprot | |
| Ssfa1 | uniprot | |
| Prpf4 | uniprot | |
| LSM2 | uniprot | |
| Ssfa1 | uniprot | |
| Prpf8 | uniprot | |
| Cstf3 | uniprot | |
| RGD1307679 | ||
| Papola | uniprot | |
| Ddx1 | uniprot | |
| HRMT1L1 | uniprot | |
| Hrmt1l2 | uniprot | |
| Pcbp2 | uniprot | |
| Dicer1 | uniprot | |
| RGD:621744 | ||
| Dhx15 | uniprot | |
| Dhx8 | ||
| Prpf4b | uniprot | |
| Nxf1 | uniprot | |
| RGD:1302963 | ||
| Cugbp1 | uniprot | |
| Rnpc2 | uniprot | |
| Brunol4 | ||
| Nono | uniprot | |
| Xrn2 | uniprot | |
| Spop | uniprot | |
| SMN1 | uniprot | |
| Cugbp2 | ||
| PTBP2 | uniprot | |
| Prpf3 | uniprot | |
| Fnbp3 | uniprot | |
| Rbm17 | uniprot | |
| Lsm7 | uniprot | |
| U2AF1 | uniprot | |
| Srpk1 | uniprot | |
| Srpk2 | uniprot | |
| Ppm1g | uniprot | |
| Srrp | ||
| SRrp40 | uniprot | |
| Rnps1 | uniprot | |
| RGD:621390 | ||
| Hnrpu | ||
| Sfrs8 | ||
| Sfpq | uniprot | |
| Pskh1 | uniprot | |
| 5 G cap | ||
| 3 | ||
| 5 | ||
| 3 | ||
| 5 | ||
| 3 | ||
| 5 | ||
| Polr2a | uniprot | |
| Spt5 | uniprot | |
| Rnmt (methyltransferase) | ||
| GMP | hmdbid:HMDB01397 | uniprot |
| mRNA Capping | ||
| Processing of Intron-Containing Pre-mRNA | ||
| iPo | ||
| Cap Binding | ||
| Methylation of mRNA | ||
| heterogeneous nuclear ribonucleoproteins | ||
| Formation of pre-mRNPs | ||
| Internal methylation of mRNA | ||
| mRNA splicing (major pathway) | ||
| pre-mRNA | ||
| Primary RNA transcript | ||
| hnRNPs | ||
| Formation of the Spliceosomal E complex | ||
| snRNP Sm core complex | ||
| U1 snRNP | ||
| 3 | ||
| exon 1 | ||
| exon 2 | ||
| intron | ||
| GU | ||
| A | ||
| YYYY | ||
| AG | ||
| 5 | ||
| SR-binding sites | ||
| SR-binding sites | ||
| U1 snRNP | ||
| U2AF | ||
| 65 | ||
| 35 | ||
| RNA helicase A | ||
| U2AF | ||
| Serine/Argenine Rich Proteins(SR) | ||
| mRNA capping | ||
| Internal methylation of mRNA | ||
| Formation of pre-mRNPs | ||
| SR-proteins | ||
| Regulation of | ||
| Alternative Splicing | ||
| Additional Factors | ||
| Regulators | ||
| splicing factor SF3A | ||
| splicing factor SF3B | ||
| U2 snRNPs | ||
| SF3b14b | uniprot | |
| SR-proteins | ||
| Additional Factors | ||
| RNA helicase | ||
| U2 snRNP | ||
| snRNP Sm core complex | ||
| Formation of the Spliceosomal A complex | ||
| Formation of the Spliceosomal E complex | ||
| Formation of the Spliceosomal A complex | ||
| U2 snRNP | ||
| 3 | ||
| A | ||
| YYYY | ||
| AG | ||
| 5 | ||
| exon 1 | ||
| exon 2 | ||
| U4/U6 | ||
| U5 | ||
| Formation of the Spliceosomal B complex | ||
| U4 snRNP | ||
| U6 snRNP | ||
| U5 snRNP | ||
| snRNP Sm core complex | ||
| U4:U5:U6 tri-snRNP complex | ||
| YYYY | ||
| AG | ||
| 5 | ||
| exon 1 | ||
| exon 2 | ||
| A | ||
| 3 | ||
| U5 | ||
| Note: New participating members shown at each step | ||
| UG | ||
| U6 | ||
| U2 | ||
| U4 | ||
| U1 | ||
| Formation of the Spliceosomal C complex | ||
| Poly(A)-binding protein II | uniprot | |
| CF II | ||
| Poly(A) polymerase alpha | uniprot | |
| CF I | chemical | |
| YYYY | ||
| AG | ||
| 5 | ||
| exon 2 | ||
| A | ||
| 3 | ||
| UG | ||
| exon 1 | ||
| YYYY | ||
| AG | ||
| 5 | ||
| A | ||
| 3 | ||
| exon 1 | ||
| exon 2 | ||
| YYYY | ||
| AG | ||
| A | ||
| 5 | ||
| exon 2 | ||
| CstF | ||
| CFI | enzyme | uniprot |
| CF II | ||
| Poly(A)pb II | ||
| Poly(A) pol | ||
| 5 | ||
| 3 | ||
| AAAAAAA | ||
| Pi | ||
| P- | ||
| degraded | ||
| SR protein kinases | ||
| Additional SR proteins | ||
| Putative Alternative Splicing | ||
| Accessory Proteins | ||
| mRNA splice site selection | ||
| hnRNP regulators | ||
| RNAi pathway | ||
| 3 | ||
| exon 1 | ||
| Formation of the Spliceosomal B complex | ||
| Formation of the active Spliceosomal C complex | ||
| Lariat Formation and 5’-Splice Site Cleavage | ||
| Cleavage at the 3’-Splice-Site and Exon Ligation | ||
| (1) | ||
| (2) | ||
| (2a) | ||
| (2b) | ||
| (2c) | ||
| (3) | ||
| mRNA 3’-end processing | ||
| Cleavage of mRNA at the 3’-end | ||
| mRNA polyadenylation | ||
| CPSF | ||
| CstF | ||
| right click on blue text for detailed information | ||
| 5 | ||
| 3 | ||
| AAUAAA | ||
| CA | ||
| ATP | hmdbid:HMDB00538 | |
| CPSF | ||
| splicesome associated helicases | ||
| Misc. | ||
| Rngtt (capping enzyme) | ||
| SR-kinases | ||
| Kinases Phosphorylating RS domains? | ||
| P | ||
| SR-phosphatases | ||
| SR-proteins | ||
| SR protein phosphatases | ||
| SR-repressor proteins |
| RBPSUHL | uniprot | |
| RBP-J | uniprot | |
| Dll4 | uniprot | |
| Dll3 | uniprot | |
| Dll1 | uniprot | |
| Jag2 | uniprot | |
| Jag1 | uniprot | |
| Lfng | uniprot | |
| Mfng | uniprot | |
| Rfng | uniprot | |
| Adam17 | uniprot | |
| Notch1 | uniprot | |
| Notch2 | uniprot | |
| Notch3 | uniprot | |
| Notch4 | uniprot | |
| Dvl1 | uniprot | |
| Dvl2 | uniprot | |
| Dvl3 | uniprot | |
| Numb | ||
| Numbl | uniprot | |
| Aph1a | uniprot | |
| Aph1b | uniprot | |
| Tnf | uniprot | |
| Psen1 | uniprot | |
| Psen2 | uniprot | |
| Ncstn | uniprot | |
| DTX1 | uniprot | |
| Dtx2 | uniprot | |
| DTX3 | uniprot | |
| Dtx4 | ||
| DTX31 | ||
| Ctbp1 | uniprot | |
| Ctbp2 | uniprot | |
| Hdac1 | uniprot | |
| Hdac2 | uniprot | |
| Ncor2 | uniprot | |
| CIR | hmdbid:HMDB00904 | uniprot |
| Ptcra | chemical | |
| Hes5 | uniprot | |
| Hes1 | uniprot | |
| SKIP | uniprot | |
| LOC330129 | ||
| Pcaf | chemical | |
| Gcn5l2 | uniprot | |
| Crebbp | uniprot | |
| MAML3 | uniprot | |
| Maml1 | uniprot | |
| NICD | ||
| co-repressor complex | ||
| DNA | CHEBI:16991 | |
| Notch Intracellular Domain | ||
| MAPK signaling pathway | ||
| gene expression | ||
| S2 | ||
| S3 | ||
| Ras/Map |
| Thra | uniprot |
| Thrb | uniprot |
| Thrb | uniprot |
| Rara | uniprot |
| Rarb | uniprot |
| Ppara | uniprot |
| Ppard | uniprot |
| Pparg | uniprot |
| Nr1d2 | uniprot |
| Nr0b1 | uniprot |
| Nr1h2 | uniprot |
| Nr1h3 | uniprot |
| Vdr | uniprot |
| Nr1i2 | uniprot |
| Nr1i3 | uniprot |
| Hnf4a | uniprot |
| Rxra | uniprot |
| Rxrg | uniprot |
| RGD:621082 | |
| Nr2f1 | uniprot |
| Nr2f2 | uniprot |
| Nr2f6 | uniprot |
| Esr1 | uniprot |
| Esr2 | uniprot |
| Nr3c1 | uniprot |
| Pgr | uniprot |
| Ar | |
| Nr4a1 | uniprot |
| Nr4a2 | uniprot |
| Nr5a1 | uniprot |
| Nr5a2 | uniprot |
| Rxrb | uniprot |
| Esrra | uniprot |
| Esrrb | uniprot |
| Rora | uniprot |
| Rorb | uniprot |
| Rorc | uniprot |
| Nr2e1 | uniprot |
| Rarg | uniprot |
| Thyroid | |
| Peroxisome Proliferator | |
| Nuclear Receptor ROR | |
| Oxysterols Receptor | |
| Vitamin D3 Receptor | uniprot |
| Hepatocyte Nuclear Factor | |
| Orphan Nuclear Receptor | |
| Nuclear receptor TLX | uniprot |
| Coup Transcription Factor | |
| Estrogen Receptor | uniprot |
| Steroid Hormone Receptor | |
| Glucocorticoid Receptor | uniprot |
| Progesterone Receptor | uniprot |
| Androgen Receptor | uniprot |
| NR5 SUPERFAMILY | |
| Steroidogenic Receptor | |
| Orphan Receptor | |
| NR0 SUPERFAMILY | |
| NR1 SUPERFAMILY | |
| NR2 SUPERFAMILY | |
| NR3 SUPERFAMILY | |
| NR4 SUPERFAMILY | |
| Orphan Receptor | |
| Activated Receptor | |
| Orphan Nuclear | |
| Receptor | |
| Retinoic Acid | hmdbid:HMDB06219 |
| Retinoic Acid Receptor (RXR) | |
| Receptor | |
| Receptor (RAR) |
| Cyp4a11 | uniprot | |
| RARa | ||
| RARg | ||
| Rarb | uniprot | |
| Cyp7a1 | uniprot | |
| Cyp7a1 | uniprot | |
| Pparg | uniprot | |
| Ppara | uniprot | |
| Abcd3 | uniprot | |
| Abcd2 | uniprot | |
| Abcb4 | uniprot | |
| Abca1 | uniprot | |
| PPARb | ||
| Abca1 | uniprot | |
| Cyp4b1 | uniprot | |
| RGD:619923 | ||
| Cyp3a13 | uniprot | |
| Cyp2c7 | uniprot | |
| Cyp24a1 | uniprot | |
| Cyp7a1 | uniprot | |
| Cyp8b1 | uniprot | |
| Abcb11 | uniprot | |
| Abca1 | uniprot | |
| Abcg1 | uniprot | |
| Abcg5 | uniprot | |
| abcg6 | ||
| Cyp27b1 | uniprot | |
| Vdr | uniprot | |
| Nr1i2 | uniprot | |
| Nr1i3 | uniprot | |
| Cyp3a13 | uniprot | |
| Cyp2c7 | uniprot | |
| Abcc2 | uniprot | |
| Abcb1a | uniprot | |
| Abcb1 | uniprot | |
| Nr1h3 | uniprot | |
| Abcc3 | uniprot | |
| Cyp3a13 | uniprot | |
| Cyp2e1 | uniprot | |
| Cyp2c7 | uniprot | |
| RGD:619923 | ||
| Cyp1a2 | uniprot | |
| Nr1h4 | uniprot | |
| Cyp26a1 | uniprot | |
| Right click for comments | ||
| Acetyl CoA | hmdbid:HMDB01206 | uniprot |
| Isoprenoids | CHEBI:24913 | |
| Lanosterol | hmdbid:HMDB01251 | |
| 7-DehydroCholesterol | hmdbid:HMDB00032 | |
| Cholesterol | hmdbid:HMDB00067 | |
| Oxysterol | chemical | |
| Bile Acids | CHEBI:3098 | |
| 1,25-Dihydroxy-Vitamins D3 | ||
| Fatty Acids | CHEBI:35366 | |
| DIET | ||
| Xenobiotics | CHEBI:35703 | |
| DIET | ||
| Retinoic Ac | ||
| Steroids | CHEBI:35341 | |
| Gene expression |
| Adora1 | uniprot |
| Adora2a | uniprot |
| Adora2b | uniprot |
| Adora3 | uniprot |
| P2ry1 | uniprot |
| P2ry1 | uniprot |
| P2ry2 | uniprot |
| P2y3 | |
| P2ry4 | uniprot |
| P2y5 | uniprot |
| P2ry6 | uniprot |
| P2y7 | |
| P2y9 | uniprot |
| Adenosine | hmdbid:HMDB00050 |
| Adenine | hmdbid:HMDB00034 |
| Gi/Go Pathway | |
| Gs Pathway | |
| Gq/G11 Pathway |
| Adsl | uniprot | |
| LOC500228 | ||
| Dhfr | uniprot | |
| Pura | uniprot | |
| Prps1 | uniprot | |
| Prps2 | uniprot | |
| Hprt | uniprot | |
| Oaz1 | uniprot | |
| Srm | uniprot | |
| Sat | ||
| Rrm1 | uniprot | |
| Pold1 | uniprot | |
| Polg | uniprot | |
| Polb | uniprot | |
| Nme2 | uniprot | |
| Impdh1 | uniprot | |
| Pola1 | uniprot | |
| Ribose | hmdbid:HMDB00283 | |
| PRPP | hmdbid:HMDB00280 | uniprot |
| SAICAR | hmdbid:HMDB00797 | |
| AICAR | hmdbid:HMDB03192 | |
| IMP | hmdbid:HMDB00175 | uniprot |
| DNA | CHEBI:16991 | |
| DNA Synthesis | ||
| dNTPs | ||
| dNTPs | ||
| GMP | hmdbid:HMDB01397 | uniprot |
| dNTPs | ||
| Xanthine | hmdbid:HMDB00292 | |
| GMP | hmdbid:HMDB01397 | uniprot |
| Guanine | hmdbid:HMDB00132 | |
| Uric Acid | hmdbid:HMDB00289 | |
| Adenylosuccinate | hmdbid:HMDB00536 | |
| AMP | hmdbid:HMDB00045 | uniprot |
| Hypoxanthine | hmdbid:HMDB00157 | |
| Spermine | hmdbid:HMDB01256 | |
| Adenine | hmdbid:HMDB00034 | |
| Spermidine | hmdbid:HMDB01257 | |
| Putrescine | hmdbid:HMDB01414 | |
| Ornithine | hmdbid:HMDB03374 | |
| Polyamine | chemical | |
| Synthesis | ||
| Monophasphate | chemical |
| Bmpr1b | uniprot |
| Prlr | uniprot |
| Fshr | uniprot |
| Lhcgr | uniprot |
| RGD:620606 | |
| RGD:620606 | |
| Fig-alpha | |
| Dmc1h | uniprot |
| Atm | uniprot |
| LOC497834 | |
| RGD:1303008 | |
| Gdf9 | uniprot |
| Smpd1 | uniprot |
| LOC503240 | |
| Gja4 | uniprot |
| Gja4 | uniprot |
| Inha | uniprot |
| Madh3 | uniprot |
| Pgr | uniprot |
| Esr2 | uniprot |
| Vdr | uniprot |
| Nr5a1 | uniprot |
| Ncor1 | uniprot |
| Nrip1 | uniprot |
| Egr1 | uniprot |
| Cebpb | uniprot |
| Ptger2 | uniprot |
| Cdkn1b | uniprot |
| Ccnd2 | uniprot |
| Cdk4 | uniprot |
| Smpd1 | uniprot |
| Cyp19a1 | uniprot |
| RGD1305248 | |
| Zp2 | uniprot |
| TF2D | uniprot |
| Granulosa Cell | |
| Cytoplasm | |
| Nucleus | CHEBI:33252 |
| Oocyte | |
| Nucleus | CHEBI:33252 |
| Ooplasm |
| Maoa | uniprot |
| Nfix | uniprot |
| Nrf2 | uniprot |
| Nfkb1 | uniprot |
| Sp1 | uniprot |
| Hmox1 | uniprot |
| Gpx1 | uniprot |
| Gpx3 | uniprot |
| Nqo1 | uniprot |
| Ugt1a6 | uniprot |
| Cat | |
| Txn2 | uniprot |
| Txnrd1 | uniprot |
| Txnrd2 | uniprot |
| Gclc | uniprot |
| Gsr | uniprot |
| Mt1a | uniprot |
| Gstt2 | uniprot |
| Mgst1 | uniprot |
| Cyp1a1 | uniprot |
| Xdh | uniprot |
| Cyba | uniprot |
| Fos | uniprot |
| Junb | uniprot |
| Sod2 | uniprot |
| Sod1 | uniprot |
| Sod3 | uniprot |
| Mapk14 | uniprot |
| Mapk10 | uniprot |
| antioxidant genes | |
| Induction of | |
| Inhibition of oxidases | |
| TF inhibition | |
| repression | |
| TF activation | |
| Immediate-early | |
| gene induction | |
| Reactive Oxygen Species | CHEBI:26523 |
| Adaptive response | |
| Repression of ROS- | |
| producing systems | |
| Activation | chemical |
| Stress-regulated MAP kinase |
| Mapk14 | uniprot | |
| Mapk14 | uniprot | |
| Map2k6 | uniprot | |
| mlk1 map3k9 | ||
| Map3k7 | uniprot | |
| Map3k5 | uniprot | |
| LOC500526 | ||
| prak | ||
| Hspb1 | uniprot | |
| Mapkapk2 | uniprot | |
| Mapkapk2 | uniprot | |
| Atf2 | uniprot | |
| Rps6ka5 | uniprot | |
| Mef2d | uniprot | |
| Ddit3 | uniprot | |
| Elk1 | uniprot | |
| Stat1 | uniprot | |
| Max | ||
| Myc | uniprot | |
| Hmgn1 | uniprot | |
| Creb1 | uniprot | |
| Pla2g4a | uniprot | |
| mkk4 | ||
| Map3k1 | uniprot | |
| Rac1 | uniprot | |
| Cdc42 | uniprot | |
| Ras | uniprot | |
| Tgfbr1 | uniprot | |
| Tgfb2 | uniprot | |
| Tradd | chemical | |
| traff2 | ||
| Daxx | uniprot | |
| ripk1 | uniprot | |
| Shc1 | uniprot | |
| Grb2 | uniprot | |
| ras-gef | ||
| Apoptosis | ||
| Translation | ||
| ? | ||
| ? | ||
| ? | ||
| Stress: Osmotic shock | ||
| g-radiation, Anisomycin | ||
| Right click for comments | ||
| FASL, Inflammatory | ||
| Cytokines, UV, etc. | ||
| Growth Factors, UV | ||
| Trophic Factors, etc. | ||
| DNA transcription | ||
| Cytokines Production, | ||
| Apoptosis, etc. | ||
| ? | ||
| ? |
| G6pdx | uniprot |
| G6pd2 | uniprot |
| Tkt | uniprot |
| Taldo1 | uniprot |
| Tkt | uniprot |
| Pgls | uniprot |
| Pgd | uniprot |
| Rpe | uniprot |
| Rpia | uniprot |
| Glucose-6-Phosphate | hmdbid:HMDB01401 |
| 6-Phosphoglucono-delta-lactone | hmdbid:HMDB01127 |
| 6-Phosphogluconate | hmdbid:HMDB01316 |
| Ribulose-5-Phosphate | hmdbid:HMDB00618 |
| Ribose-5-Phosphate | hmdbid:HMDB01548 |
| (Hexose Monophosphosphate Shunt | |
| or Phosphogluconate Pathway) | |
| Fructose-6-Phosphate + Erythose-4-Phosphate | |
| Fructose-6-Phosphate | hmdbid:HMDB00124 |
| Sedoheptulose-7-Phosphate | hmdbid:HMDB01068 |
| + | |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 |
| + | |
| Glycolysis/Gluconeogenesis | |
| Xylulose-5-Phosphate | hmdbid:HMDB00868 |
| Glyceraldehyde-3-Phosphate | hmdbid:HMDB01112 |
| Nucleotide | chemical |
| Biosynthesis |
| Agtr1a | uniprot | |
| Agtr1 | uniprot | |
| Agtr1 | uniprot | |
| Bdkrb2 | uniprot | |
| Bdkrb1 | uniprot | |
| Nmbr | uniprot | |
| Grpr | uniprot | |
| Brs3 | uniprot | |
| Ccr9 | uniprot | |
| Cxcr4 | uniprot | |
| Ccr5 | uniprot | |
| Cx3cr1 | uniprot | |
| C3ar1 | uniprot | |
| C5r1 | uniprot | |
| Il8rb | uniprot | |
| Cckar | uniprot | |
| Cckbr | uniprot | |
| Ednra | uniprot | |
| Ednrb | uniprot | |
| Galr1 | uniprot | |
| Galr2 | uniprot | |
| Galr3 | uniprot | |
| Fshr | uniprot | |
| Lhcgr | uniprot | |
| Tshr | uniprot | |
| Mc2r | uniprot | |
| Mc3r | uniprot | |
| Mc4r | uniprot | |
| Mc5r | uniprot | |
| Npy1r | uniprot | |
| Npy2r | uniprot | |
| Ppyr1 | uniprot | |
| Npy5r | uniprot | |
| Ntsr2 | uniprot | |
| Oprd1 | uniprot | |
| Oprk1 | uniprot | |
| Oprm1 | uniprot | |
| Oprl | uniprot | |
| Gnrhr | uniprot | |
| Trhr | uniprot | |
| Ghsr | uniprot | |
| Tacr1 | uniprot | |
| Tacr3 | uniprot | |
| Tacr2 | uniprot | |
| Sstr1 | uniprot | |
| Sstr2 | uniprot | |
| Sstr3 | uniprot | |
| Sstr4 | uniprot | |
| Sstr5 | uniprot | |
| Avpr1a | uniprot | |
| Avpr1b | uniprot | |
| Oxtr | uniprot | |
| Avpr2 | uniprot | |
| Il8ra | uniprot | |
| FMLP-R1 | ||
| Agtr2 | uniprot | |
| FMLP3-R | ||
| FMLPR-2 | ||
| Mc1r | uniprot | |
| Npy6r | uniprot | |
| Ntsr1 | uniprot | |
| NK4-R | ||
| Cmkbr6 | uniprot | |
| Ccr7 | uniprot | |
| Ccr2 | uniprot | |
| Ccr3 | uniprot | |
| Ccr4 | uniprot | |
| Ccr5 | uniprot | |
| Cmkbr1 | uniprot | |
| Ccr8 | uniprot | |
| Ccr10 | uniprot | |
| Cmkbr1l1 | uniprot | |
| Bonzo | chemical | |
| Cx3cr | ||
| Gpfy | ||
| Releasing Hormone | ||
| Receptors | ||
| Opioid Receptors | ||
| Neuropeptide Y Receptors | uniprot | |
| Chemokine Receptors | ||
| Chemotactic Receptors | ||
| Angiotensin Receptors | ||
| Bombesin Receptors | ||
| Endothelin Receptors | ||
| Vasopressin and | ||
| Oxytocin | hmdbid:HMDB02865 | uniprot |
| Galanin Receptors | ||
| Receptors | ||
| Glycoprotein Hormone | ||
| Receptors | ||
| Cholecystokinin/ | ||
| Bradykinin Receptors | ||
| Somatostatin Receptors | ||
| Tachykinin Receptors | ||
| Gq Coupled | ||
| Gi Coupled | ||
| Gs Coupled | ||
| Gastrin Receptors | ||
| Melanocortins | ||
| Neurotensin Receptors |
| Ptgs1 | uniprot | |
| Ptgs2 | uniprot | |
| Anxa2 | uniprot | |
| Anxa1 | uniprot | |
| Anxa6 | uniprot | |
| Anxa4 | uniprot | |
| Scgb1a1 | uniprot | |
| Anxa5 | uniprot | |
| S100a6 | uniprot | |
| Hsd11b1 | uniprot | |
| Ednrb | uniprot | |
| Edn1 | uniprot | |
| Hpgd | uniprot | |
| Prl | uniprot | |
| Dtprp | chemical | |
| Ednra | uniprot | |
| Hsd11b2 | uniprot | |
| Pla2g4a | uniprot | |
| S100a10 | uniprot | |
| Ptgis | uniprot | |
| Ptgds | uniprot | |
| Tbxas1 | uniprot | |
| Ptger1 | uniprot | |
| Ptger2 | uniprot | |
| Ptger3 | uniprot | |
| Ptger4 | uniprot | |
| Ptgfr | uniprot | |
| Anxa3 | uniprot | |
| Anxa8 | uniprot | |
| Ptgir | uniprot | |
| Cyp11a1 | uniprot | |
| Ptgdr | uniprot | |
| PGF2 | uniprot | |
| PGI2 | hmdbid:HMDB01335 | uniprot |
| Ca | ||
| 2+ | ||
| Prostaglandin H2 | hmdbid:HMDB01381 | |
| TXA2 | hmdbid:HMDB01452 | |
| Cortisol | hmdbid:HMDB00063 | |
| PGE2 | hmdbid:HMDB01220 | |
| Cell Membrane | ||
| Phospholipids | CHEBI:16247 | |
| Inactive Metabolites | ||
| Cytoplasm | ||
| PG Synthases | ||
| Cortisone | hmdbid:HMDB02802 | |
| Cortisol | hmdbid:HMDB00063 | |
| Arachidonic Acid | hmdbid:HMDB01043 | |
| Progesterone | hmdbid:HMDB01830 | |
| Gq signaling | ||
| pathway | ||
| PGF2 | uniprot | |
| Annexins | chemical | |
| release | ||
| prolactin | uniprot | |
| Annexins | chemical | |
| Ca | ||
| 2+ | ||
| PG Synthases | ||
| PG Receptors | ||
| PG Receptors |
| Ubc | uniprot | |
| Hist1h2aa | ||
| Ccl2 | uniprot | |
| H2afz | uniprot | |
| UBE1X | ||
| Ube1l | ||
| Psmc1 | uniprot | |
| Nedd4a | uniprot | |
| Psmc6 | uniprot | |
| Psmd1 | uniprot | |
| Psmd2 | uniprot | |
| Psmd3 | uniprot | |
| Psmd5 | uniprot | |
| Psmd4 | uniprot | |
| PSMC5 | uniprot | |
| Psmc2 | uniprot | |
| Psmc3 | uniprot | |
| Psmc4 | uniprot | |
| Psma1 | uniprot | |
| Psma2 | uniprot | |
| Psmb1 | uniprot | |
| Psma3 | uniprot | |
| Psma4 | uniprot | |
| Psmb3 | uniprot | |
| Psmb6 | uniprot | |
| Psmb7 | uniprot | |
| Psmb5 | uniprot | |
| Psmb4 | uniprot | |
| Psme1 | uniprot | |
| Psme2 | uniprot | |
| Ifng | uniprot | |
| Psmb9 | uniprot | |
| Psmb10 | uniprot | |
| Psmb8 | uniprot | |
| Psme3 | uniprot | |
| Psmd7 | uniprot | |
| PSMD6 | uniprot | |
| Psmd8 | uniprot | |
| Psmd9 | uniprot | |
| Psmd10 | uniprot | |
| Psmd11 | uniprot | |
| Psmd12 | uniprot | |
| Psmd13 | uniprot | |
| Psma6 | uniprot | |
| Psma7 | uniprot | |
| Psma5 | uniprot | |
| Psmb2 | uniprot | |
| Rpn2 | uniprot | |
| Rpn1 | uniprot | |
| RGD:708345 | ||
| Ube2d2 | uniprot | |
| Ube2g1 | uniprot | |
| RGD:621096 | ||
| ATP | hmdbid:HMDB00538 | |
| AMP Ubiquitin/E1 Complex | ||
| Ubiquitin/E2 Complex | ||
| E3/Protein | ||
| Proteins to be Degraded | ||
| Ubiquitin/Protein | ||
| Proteasome 26 S | ||
| (PA700) (ATP dependent) | ||
| p45 ATPase Subunit | ||
| Unfolds and Degrades | ||
| Intact Proteins | ||
| Proteasome 20S | ||
| Catalytic Core (p45) | ||
| Activators of | ||
| Degrades only Peptides | ||
| Presentation by MHC class 1 | ||
| Oxidatively Damaged | ||
| Cytosolic Proteins | ||
| 20S Complex | ||
| Lid subunits | ||
| Alpha subunits | ||
| Beta subunits |
| Ins1 | uniprot |
| Egfr | uniprot |
| Itga1 | uniprot |
| F2r | uniprot |
| F2 | |
| Fn1 | uniprot |
| Gna12 | uniprot |
| Sos2 | uniprot |
| Gna13 | uniprot |
| Arhgef6 | uniprot |
| Csk | uniprot |
| Vav1 | uniprot |
| Bcar1 | uniprot |
| Crk | uniprot |
| Ptk2 | uniprot |
| Mos | uniprot |
| Map2k1 | uniprot |
| Mapk1 | uniprot |
| Chrm1 | uniprot |
| Gng12 | uniprot |
| Fgd1 | uniprot |
| Cdc42 | uniprot |
| Iqgap1 | uniprot |
| Arhgef1 | uniprot |
| Diap3 | uniprot |
| Baiap2 | uniprot |
| Enah | uniprot |
| WAS | |
| Arpc5 | uniprot |
| Actb | uniprot |
| Rhoa | uniprot |
| Rock1 | uniprot |
| Grlf1 | uniprot |
| Rac | uniprot |
| Rac1 | uniprot |
| Rac4 | chemical |
| Rac3 | uniprot |
| Rac2 | uniprot |
| Cd14 | uniprot |
| Ins2 | uniprot |
| Egf | uniprot |
| Fgf1 | uniprot |
| Fgf2 | uniprot |
| Fgf3 | uniprot |
| Fgf4 | uniprot |
| Fgf5 | uniprot |
| Fgf9 | uniprot |
| Fgf14 | uniprot |
| Fgf20 | uniprot |
| Pdgfb | uniprot |
| Fgf6 | uniprot |
| Fgf11 | uniprot |
| Fgf16 | uniprot |
| Fgf22 | uniprot |
| Fgf7 | uniprot |
| Fgf12 | uniprot |
| Fgf17 | uniprot |
| Fgf23 | uniprot |
| Fgf8 | uniprot |
| Fgf13 | uniprot |
| Fgf18 | uniprot |
| Pdgfa | uniprot |
| Fgf10 | uniprot |
| Fgf15 | uniprot |
| Fgf21 | uniprot |
| Fgfr1 | uniprot |
| Fgfr3 | uniprot |
| Fgfr2 | uniprot |
| Fgfr4 | uniprot |
| Pdgfra | uniprot |
| Pdgfrb | uniprot |
| Sos2 | uniprot |
| Rras | uniprot |
| Rras2 | uniprot |
| Mras | uniprot |
| Hras | uniprot |
| Nras | uniprot |
| Kras2 | uniprot |
| P101-PI3K | uniprot |
| Pik3r4 | uniprot |
| Pik3c2a | uniprot |
| Pik3c2b | |
| Pik3c2g | uniprot |
| Pik3c3 | uniprot |
| Pik3ca | uniprot |
| Pik3cb | uniprot |
| Pik3cd | uniprot |
| Pik3cg | uniprot |
| Arhgef4 | uniprot |
| Pik3r2 | uniprot |
| Pik3r1 | uniprot |
| Pik3r3 | uniprot |
| Raf1 | uniprot |
| Braf | uniprot |
| Map2k2 | uniprot |
| Mapk3 | uniprot |
| Mapk4 | uniprot |
| Mapk6 | uniprot |
| Dock1 | uniprot |
| Chrm2 | uniprot |
| Chrm3 | uniprot |
| Chrm4 | uniprot |
| Bdkrb2 | uniprot |
| Bdkrb1 | uniprot |
| Chrm5 | uniprot |
| Rock2 | uniprot |
| arhgef6 | uniprot |
| Arhgef7 | uniprot |
| Actg | uniprot |
| Apc | uniprot |
| Apc2 | uniprot |
| Pak1 | uniprot |
| Pak2 | uniprot |
| Pak3 | uniprot |
| Pak4 | uniprot |
| Pak6 | |
| Pak7 | uniprot |
| Pfn1 | uniprot |
| Wasf2 | uniprot |
| Baiap2 | uniprot |
| Arpc5 | uniprot |
| Actb | uniprot |
| Actg | uniprot |
| Abi2 | uniprot |
| Nckap1 | uniprot |
| Cyfip2 | chemical |
| Wasf1 | uniprot |
| C3orf10 | |
| Tmsb4x | uniprot |
| Vil2 | uniprot |
| Pxn | uniprot |
| Git1 | uniprot |
| Rdx | uniprot |
| Vil | uniprot |
| Slc9a1 | uniprot |
| Pip5k2a | uniprot |
| Msn | uniprot |
| Pip5k1a | uniprot |
| Pip5k1b | uniprot |
| Pip5k2b | uniprot |
| Pip5k1c | uniprot |
| Diap1 | uniprot |
| Pfn1 | uniprot |
| Pip5k2c | |
| Pip5kl1 | |
| Vcl | uniprot |
| Actn1 | uniprot |
| Ppp1r12a | uniprot |
| Mylk | uniprot |
| Pip5k2a | uniprot |
| Limk1 | uniprot |
| Myl1 | uniprot |
| Cfl1 | uniprot |
| Myl3 | uniprot |
| Ssh1 | uniprot |
| Cfl2 | uniprot |
| RGD1304598 | |
| Ssh3 | uniprot |
| Vcl | uniprot |
| RGD:1303089 | |
| Myh10 | uniprot |
| Actg | uniprot |
| Actb | uniprot |
| Growth Factors | |
| Growth Factor (GF) | |
| RTK | |
| RTK | |
| RAS | uniprot |
| Ras | uniprot |
| PI3K | uniprot |
| PI3K | uniprot |
| Bradykinin | uniprot |
| Acetylcholine | hmdbid:HMDB00895 |
| Chemotactic factor | |
| LPS | CHEBI:16412 |
| Chemotactic factor | |
| PIP3 | uniprot |
| Actin | uniprot |
| polymerization | chemical |
| Focal adhesion | |
| assembly | |
| PIP2 | uniprot |
| PIP2 | uniprot |
| ? | |
| Stabilization | |
| of actin | |
| Lamellipodia | |
| -p | |
| +p | |
| Actin polymerization | |
| stress fiber | |
| Integrin-mediated | |
| cell adhesion | |
| Actomyosin | enzyme |
| assembly contraction | |
| Focal complex | |
| assembly | |
| Integrin-mediated | |
| cell adhesion | |
| stress fiber | |
| Gene Expression | |
| Cadherin-mediated | |
| cell adhesion | |
| Filipodia | |
| MAPK Signaling | |
| pathway | |
| Actin polymerization |
| Rps16 | uniprot |
| Rps6ka1 | uniprot |
| Rps6kb1 | uniprot |
| Rpl4 | uniprot |
| Rpl5 | uniprot |
| Rpl6 | uniprot |
| Rpl8 | uniprot |
| Rpl9 | uniprot |
| Rpl10 | uniprot |
| Rpl10a | uniprot |
| Rpl13 | uniprot |
| Rpl13a | uniprot |
| Rpl14 | uniprot |
| Rpl15 | uniprot |
| RGD:1303019 | |
| Rpl18 | uniprot |
| Rpl19 | uniprot |
| Rpl21 | uniprot |
| Rpl22 | uniprot |
| Rpl23 | uniprot |
| Rpl27 | uniprot |
| Rpl28 | uniprot |
| Rpl29 | uniprot |
| Rpl30 | uniprot |
| Rpl31 | uniprot |
| Rpl32 | uniprot |
| Rpl35a | uniprot |
| Rpl36 | uniprot |
| Rpl37 | uniprot |
| Rpl39 | uniprot |
| Uba52 | uniprot |
| Rpl41 | uniprot |
| RGD:621156 | |
| Arbp | uniprot |
| Rplp1 | uniprot |
| Rplp2 | uniprot |
| Lamr1 | uniprot |
| Rps2 | uniprot |
| Rps3 | uniprot |
| Rps3a | uniprot |
| Rps4x | uniprot |
| Rps5 | uniprot |
| Rps6 | uniprot |
| Rps7 | uniprot |
| Rps8 | uniprot |
| Rps9 | uniprot |
| Rps10 | uniprot |
| Rps11 | uniprot |
| Rps12 | uniprot |
| Rps13 | uniprot |
| Rps14 | uniprot |
| Rps15 | uniprot |
| Rps15a | uniprot |
| Rps17 | uniprot |
| Rps19 | uniprot |
| Rps20 | uniprot |
| Rps21 | uniprot |
| Rps24 | uniprot |
| Rps26 | uniprot |
| Rps27 | uniprot |
| Rps27a | uniprot |
| Rps28 | uniprot |
| Rps29 | uniprot |
| Fau | uniprot |
| Rpl7 | uniprot |
| L18Ae | |
| L12e | |
| L11e | |
| L7Ae | |
| L3e | |
| Rpl24 | uniprot |
| Rpl23a | uniprot |
| Rpl26 | uniprot |
| Rpl27a | uniprot |
| Rpl34 | uniprot |
| Rpl35 | uniprot |
| Rpl37a | uniprot |
| Acly | uniprot |
| S18e | |
| Rps23 | uniprot |
| S25e | |
| Large (60S) Subunit | |
| Small (40S) Subunit |
| Tbp | uniprot |
| Gtf2a2 | uniprot |
| Gtf2f2 | uniprot |
| Cdk7 | uniprot |
| Polr1b | uniprot |
| Polr3e | uniprot |
| Polr3k | uniprot |
| Polr1e | uniprot |
| Polr2g | uniprot |
| Polr1d | uniprot |
| Ccnh | uniprot |
| Mnat1 | uniprot |
| Taf5 | uniprot |
| Taf7 | uniprot |
| RGD:727861 | |
| Taf6 | uniprot |
| Ilk | uniprot |
| Taf12 | uniprot |
| Taf13 | uniprot |
| Gtf2b | uniprot |
| Gtf2e1 | uniprot |
| Gtf2e2 | uniprot |
| Gtf2h1 | uniprot |
| Gtf2h2 | uniprot |
| Gtf2h3 | uniprot |
| RGD:1303309 | |
| Ercc3 | uniprot |
| Ercc2 | uniprot |
| Polr1a | uniprot |
| Polr2a | uniprot |
| Polr2b | uniprot |
| Polr2c | uniprot |
| Polr2e | uniprot |
| RGD:708567 | |
| Polr2h | uniprot |
| Polr2k | uniprot |
| Polr2i | uniprot |
| Polr2j | uniprot |
| Polr3b | uniprot |
| Polr3d | uniprot |
| Rpc8 | chemical |
| TATA | |
| 5 | |
| 3 | |
| 3 | |
| 5 | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| TATA | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| dsDNA | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| 5 | |
| 3 | |
| 5 | |
| Primary RNA transcript | |
| RNA polymerase II | enzyme |
| (mRNA, snRNPs) | |
| RNA polymerase I | enzyme |
| (large ribosomal RNAs) | |
| RNA polymerase III | enzyme |
| (small stable RNAs) | |
| cell growth | |
| Gene Regulatory Proteins | |
| (recognize surface DNA geometry) | |
| TFIID | uniprot |
| TFIIB | uniprot |
| Transcription Initiation Factors (TIFs) | |
| TFIIE | |
| TFIIA | |
| TFIIF | |
| TFIID | uniprot |
| TFIIB | uniprot |
| TFIIH | |
| TFIIF | |
| TATA | |
| TFIIF | |
| RNA pol II | |
| TFIIH | |
| TFIIE | |
| TATA Box binding | |
| protein | CHEBI:16541 |
| Steps 1) TBP binds TATA box | |
| Steps 2) Association of TIFs and RNA polymerase | |
| Steps 3) DNA melting by association with TFIIH | |
| Steps 4) Transcription elongation by NTPs | |
| Steps 5) RNA elongation with CDT phosphorylation | |
| TFIIA |
| Mapk3 | uniprot |
| Mapk1 | uniprot |
| Mapk6 | uniprot |
| Mapk7 | uniprot |
| Mapk12 | uniprot |
| Sphk1 | |
| SK2 | uniprot |
| Asah2 | uniprot |
| Smpd2 | uniprot |
| S1P3 (EDG-3) | |
| S1P2 (EDG-5) | |
| Edg1 | uniprot |
| S1P5 (EDG-8) | |
| Plcb3 | uniprot |
| Akt1 | uniprot |
| Pik3c2g | uniprot |
| Akt2 | uniprot |
| Akt3 | uniprot |
| Gnai1 | uniprot |
| Gnai2 | uniprot |
| Gnai3 | uniprot |
| Racgap1 | uniprot |
| GPCRs similar to S1P |
| Itgb1 | uniprot |
| Integrin-A | |
| Ptk2b | uniprot |
| Pxn | uniprot |
| Ptk2 | uniprot |
| Src | uniprot |
| Pten | uniprot |
| Pxn | uniprot |
| Ptk2 | uniprot |
| SRC | uniprot |
| Ptk2b | uniprot |
| Rasa1 | uniprot |
| Pik3ca | uniprot |
| Gab1 | uniprot |
| Ptpn11 | uniprot |
| Grb2 | uniprot |
| STAT3 | uniprot |
| Sos1 | uniprot |
| Crkl | uniprot |
| Crk | uniprot |
| Rapgef1 | chemical |
| RAP-1A | |
| Rap1b | uniprot |
| Hras | uniprot |
| Mapk8 | uniprot |
| Map4k1 | uniprot |
| Elk1 | uniprot |
| Raf1 | uniprot |
| Map2k1 | uniprot |
| Map2k2 | uniprot |
| Mapk1 | uniprot |
| Mapk3 | uniprot |
| Jun | uniprot |
| Fos | uniprot |
| PAK1 | uniprot |
| Met | |
| Hgf | uniprot |
| Dock1 | uniprot |
| P | |
| P | |
| P | |
| Trancription | |
| Transcription | |
| AP-1 | uniprot |
| Transcription | |
| of Cox2 | |
| Anoikis | |
| AKT Pathway | |
| Actin | uniprot |
| RHO | uniprot |
| Pathway | |
| RAC1 | uniprot |
| Pathway | |
| CDC42 | uniprot |
| Pathway | |
| Changes in Cytoskeleton | |
| and Cell mobility | |
| Extracellular | |
| Cytoplasm | |
| Right Click for Comments |
| Cnr1 | uniprot |
| Cnr2 | uniprot |
| Edg1 | uniprot |
| Edg2 | uniprot |
| Edg3 | uniprot |
| Edg5 | uniprot |
| Mtnr1a | uniprot |
| Mtnr1b | uniprot |
| Ptafr | uniprot |
| Ptger1 | uniprot |
| Ptger2 | uniprot |
| Ptger3 | uniprot |
| Ptger4 | uniprot |
| Ptgfr | uniprot |
| Tbxa2r | uniprot |
| Edg6 | uniprot |
| Mtnr1c | uniprot |
| Pgd2 | chemical |
| Ptgir | uniprot |
| Prostanoids | CHEBI:26347 |
| Melatonin | hmdbid:HMDB01389 |
| Platelet Activating | |
| Lysophosphatidic | chemical |
| Acid | CHEBI:37527 |
| Cannabinoid | chemical |
| Gq/G11 Pathway | |
| Gq/G11 Pathway | |
| Gi Pathway |
| Prkar1b | uniprot | |
| Adcy2 | uniprot | |
| Prkca | uniprot | |
| Prkcb | uniprot | |
| Prkcc | uniprot | |
| Prkcd | uniprot | |
| Prkcl | ||
| Prkch | uniprot | |
| Prkcm | uniprot | |
| PRKCQ | uniprot | |
| Prkcz | uniprot | |
| Prkce | uniprot | |
| Prkacb | uniprot | |
| Adcy6 | uniprot | |
| Adcy8 | uniprot | |
| Prkar2a | uniprot | |
| Prkar2b | uniprot | |
| Prkaca | uniprot | |
| Adcy9 | uniprot | |
| Prkar1a | uniprot | |
| Adcy3 | uniprot | |
| Adcy5 | uniprot | |
| Nppa | uniprot | |
| Rgs1 | uniprot | |
| Rgs3 | uniprot | |
| Rgs4 | uniprot | |
| Rgs5 | uniprot | |
| Rgs6 | uniprot | |
| Rgs7 | uniprot | |
| Rgs9 | uniprot | |
| Rgs10 | uniprot | |
| Rgs11 | uniprot | |
| Rgs14 | uniprot | |
| Rgs16 | uniprot | |
| Rgs17 | uniprot | |
| Rgs18 | uniprot | |
| Rgs19 | uniprot | |
| Rgs20 | uniprot | |
| Adcy4 | uniprot | |
| Adcy1 | uniprot | |
| Rgs2 | uniprot | |
| Adcy7 | uniprot | |
| Gabpb1 | uniprot | |
| Sp1 | uniprot | |
| Nfkb1 | uniprot | |
| Ets2 | uniprot | |
| Igfbp1 | uniprot | |
| Igfbp2 | uniprot | |
| Adm | uniprot | |
| Oxtr | uniprot | |
| Igfbp6 | uniprot | |
| RGD:1302973 | ||
| Nos1 | uniprot | |
| Crh | uniprot | |
| Igfbp3 | uniprot | |
| Crhr1 | uniprot | |
| Rln1 | uniprot | |
| Nos3 | uniprot | |
| Fos | uniprot | |
| Oxt | uniprot | |
| Ywhaz | uniprot | |
| Ywhae | uniprot | |
| Ywhah | uniprot | |
| Ywhag | uniprot | |
| Sfn | uniprot | |
| Ywhaq | uniprot | |
| Gja1 | uniprot | |
| Il1b | uniprot | |
| Il6 | uniprot | |
| Gnaq | uniprot | |
| Cmkor1 | uniprot | |
| Admr | uniprot | |
| Oxtr | uniprot | |
| Jun | uniprot | |
| Pde4b | uniprot | |
| Pde4d | uniprot | |
| Camk2d | uniprot | |
| Ywhab | uniprot | |
| Calm1 | uniprot | |
| Camk2b | uniprot | |
| Gabpa | uniprot | |
| Camk2a | uniprot | |
| Maff | uniprot | |
| Lgr8 | uniprot | |
| Igfbp5 | uniprot | |
| Cnn1 | uniprot | |
| Plcb3 | uniprot | |
| Cnn2 | uniprot | |
| Myl4 | uniprot | |
| Myl2 | uniprot | |
| Itpr1 | uniprot | |
| Guca2a | uniprot | |
| Guca2b | uniprot | |
| Gucy2e | uniprot | |
| Gucy1a3 | uniprot | |
| Gprk5 | uniprot | |
| Gprk6 | uniprot | |
| Gnb1 | uniprot | |
| Gnb2 | uniprot | |
| Gnb3 | uniprot | |
| Gnb4 | uniprot | |
| Gnb5 | uniprot | |
| Gng1 | uniprot | |
| Gng2 | uniprot | |
| Gng3 | uniprot | |
| Gng4 | uniprot | |
| Gng7 | uniprot | |
| Gng8 | uniprot | |
| Gng12 | uniprot | |
| Gng13 | uniprot | |
| Gng5 | uniprot | |
| Gng11 | uniprot | |
| Atf2 | uniprot | |
| Atf3 | uniprot | |
| Creb3 | uniprot | |
| Atf5 | uniprot | |
| Atf4 | uniprot | |
| Atf1 | uniprot | |
| Creb1 | uniprot | |
| Gprk2l | uniprot | |
| Gnas | uniprot | |
| Calm2 | uniprot | |
| Pkia | uniprot | |
| Pkib | uniprot | |
| Pkig | uniprot | |
| Calca | uniprot | |
| Crcp | uniprot | |
| Calm3 | uniprot | |
| RGD:1303317 | ||
| Itpr2 | uniprot | |
| Itpr3 | uniprot | |
| Dgkz | uniprot | |
| Plcd | uniprot | |
| Plcg1 | uniprot | |
| Plcg2 | uniprot | |
| Plcb3 | uniprot | |
| Gsto1 | uniprot | |
| Ryr3 | ||
| Atp2a2 | uniprot | |
| Arrb1 | uniprot | |
| Arrb2 | uniprot | |
| Cacnb3 | uniprot | |
| Slc8a1 | uniprot | |
| Edg2 | uniprot | |
| Cald1 | uniprot | |
| Acta1 | uniprot | |
| RGD:621676 | ||
| Actb | uniprot | |
| Actc1 | uniprot | |
| Actg | uniprot | |
| Ramp1 | uniprot | |
| Ramp2 | uniprot | |
| Ramp3 | uniprot | |
| Camk2g | uniprot | |
| Mylk2 | uniprot | |
| Ryr1 | ||
| Atp2a3 | uniprot | |
| Ryr2 | ||
| Igfbp4 | uniprot | |
| Protein Kinase A | uniprot | |
| Protein Kinase C | uniprot | |
| TR | ||
| TR = Transcriptional Regulation | ||
| note: see gene backpages for references | ||
| Regulators of G-protein | ||
| Signaling | ||
| IGFBP | ||
| Adenylyl Cyclases | ||
| Activation Via CRH and cAMP | ||
| PKC inhibitor Protein-1 | ||
| Pathways of Myometrial Relaxation | ||
| Pathways of Myometrial Contraction | ||
| cAMP | hmdbid:HMDB00058 | |
| cGMP | hmdbid:HMDB01314 | |
| Predicted OT-R | ||
| Predicted Cxn43 | ||
| Ets complex | ||
| Pge2 | chemical | |
| Nucleus | CHEBI:33252 | |
| AP-1 complex | ||
| Myometrial Relaxation | ||
| Adenylyl Cyclases | enzyme | uniprot |
| PKA | enzyme | |
| Myometrial Contraction | ||
| PKC | enzyme | uniprot |
| PKC inhibitor 1 | ||
| RGS | hmdbid:HMDB00131 | uniprot |
| G | ||
| bg | ||
| bg | ||
| DAG | uniprot | |
| G | ||
| Calcium Mobilization | ||
| IGFBP | ||
| TR | ||
| NO | ||
| Transcriptional | ||
| CRE-Transcription Factors | ||
| bg | ||
| G | ||
| IP3 | ||
| Pip2 | chemical | |
| GRK | ||
| GRK | ||
| Cell Growth | ||
| GPCR Kinase | enzyme | |
| PKA Inhibitors | ||
| Regulators | ||
| Phospholipase-C | chemical | |
| Camk2 | ||
| IP3 Receptor | ||
| SR | ||
| IP3 Receptor | ||
| Calmodulin | uniprot | |
| Phospholipase-C | chemical | |
| CAM-Kinase 2 | ||
| beta Arrestin | ||
| beta Arrestin | ||
| beta Arrestin | ||
| Calcium Influx | ||
| + | ||
| Ca | ||
| 2+ | ||
| LPA | uniprot | |
| Ca | ||
| 2+ | ||
| Na | ||
| cAMP | hmdbid:HMDB00058 | |
| MAPK | enzyme | uniprot |
| 2+ | ||
| Mg | ||
| ATP | hmdbid:HMDB00538 | |
| ADP | hmdbid:HMDB01341 | uniprot |
| Mlck | ||
| P | ||
| - | ||
| ATP | hmdbid:HMDB00538 | |
| Pi + ADP | ||
| RAMP | uniprot | |
| RAMP | uniprot | |
| Ca++/Calmodulin | ||
| Ryr | ||
| Ryanodine Receptor (Ryr) |
| Hmgcr | uniprot | |
| Cyp7a1 | uniprot | |
| Soat1 | uniprot | |
| Dgat1 | uniprot | |
| Ldlr | uniprot | |
| Lpl | uniprot | |
| Lipc | uniprot | |
| Lcat | uniprot | |
| Abca1 | uniprot | |
| Apoa1 | uniprot | |
| Apoa4 | uniprot | |
| Apoc1 | uniprot | |
| Apoe | uniprot | |
| Apoc2 | uniprot | |
| Apoc3 | uniprot | |
| Scarb1 | uniprot | |
| Lrp1 | uniprot | |
| Mttp | uniprot | |
| Cetp | chemical | |
| Ptlp | chemical | |
| Cell Membrane | ||
| Statin | hmdbid:HMDB05007 | |
| acetylCoA | hmdbid:HMDB01206 | uniprot |
| Cholesterol | hmdbid:HMDB00067 | |
| Cholic Acid | hmdbid:HMDB00619 | |
| Free FA | ||
| Cholesterol Ester | ||
| Phospholipid | CHEBI:16247 | |
| Triglycerides | chemical | |
| Liver cell | ||
| LDL | ||
| IDL | ||
| VLDL | ||
| HDL | ||
| Cholesterol | hmdbid:HMDB00067 | |
| Tissues | ||
| Plasma |
| Cyp17a1 | uniprot |
| Hydroxyprogesterone aldolase | |
| Hsd3b1 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b | uniprot |
| Hsd3b1 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| Hsd3b1 | uniprot |
| Cyp17a1 | uniprot |
| Hydroxyprogesterone aldolase | |
| Hsd3b6 | uniprot |
| Steroid-19-Hydroxylase | chemical |
| Steroid-19-Hydroxylase | chemical |
| Hsd17b1 | uniprot |
| Hsd17b2 | uniprot |
| Hsd17b3 | uniprot |
| Hsd17b4 | uniprot |
| Hsd17b7 | uniprot |
| Hsd3b5 | uniprot |
| Hsd3b6 | uniprot |
| F13b | uniprot |
| Cholesterol | hmdbid:HMDB00067 |
| Pregnenolone | hmdbid:HMDB00253 |
| Progesterone | hmdbid:HMDB01830 |
| 17-alpha-OH-Pregnenolone | chemical |
| 17-alpha-OH-Progesterone | chemical |
| DHA | hmdbid:HMDB00077 |
| Androstenedione | hmdbid:HMDB00053 |
| Androstenediol | hmdbid:HMDB03818 |
| Testosterone | hmdbid:HMDB02998 |
| Estrone | hmdbid:HMDB01425 |
| Estradiol | hmdbid:HMDB00151 |
| * 3-beta-OH-delta-steroid DH & Steroid isomerase = | |
| ** Estradiol-17-beta DH = DHB | |
| To Mineralcorticoid Synthesis | |
| To Glucocorticoid Synthesis | |
| * | |
| * | |
| * | |
| ** | |
| Dihydrotestosterone | hmdbid:HMDB02961 |
| * |
| Myh6 | uniprot |
| Myh8 | uniprot |
| Acta1 | uniprot |
| Actc1 | uniprot |
| Tnni1 | uniprot |
| Tnnt2 | uniprot |
| RGD:621546 | |
| Dmd | uniprot |
| Vim | uniprot |
| Tnni2 | uniprot |
| Tnni3 | uniprot |
| Tnnt3 | uniprot |
| Tnnt1 | uniprot |
| Myl3 | uniprot |
| Myh3 | uniprot |
| Actn3 | uniprot |
| Actn4 | uniprot |
| Tmod1 | uniprot |
| Myom1 | uniprot |
| Des | |
| Tpm4 | uniprot |
| Tpm1 | uniprot |
| RGD:735102 | |
| RGD:621676 | |
| Actg | uniprot |
| Actn2 | uniprot |
| Mybpc2 | uniprot |
| Mybpc3 | uniprot |
| Myl2 | uniprot |
| Myl1 | uniprot |
| Myl9 | uniprot |
| Myl4 | uniprot |
| Neb | |
| Tcap | uniprot |
| Ttn | |
| Titin | uniprot |
| Tncc | uniprot |
| Tnnc2 | uniprot |
| Tpm2 | uniprot |
| Myosin Light Chain | |
| Myosin Heavy Chain | uniprot |
| Tropomyosin | uniprot |
| Other Structural | |
| M Disk | |
| Z Disk | |
| Z Disk | |
| Myosin Binding | |
| A Model of Triggering of Striated Muscle | |
| Contraction by Ca++ | |
| Troponin-T | uniprot |
| Troponin-I | uniprot |
| Troponin-C | uniprot |
| Actin | uniprot |
| Actin | uniprot |
| Myosin Binding Site | |
| (Covered) | |
| Ca | |
| Ca | |
| Myosin Head | |
| Regulatory Proteins |
| Bdh | uniprot | |
| Acat1 | uniprot | |
| Hmgcl | uniprot | |
| Hmgcs2 | uniprot | |
| 3-Hydroxy-butyrate | chemical | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Acetoacetyl-CoA | hmdbid:HMDB01484 | |
| 3-Hydroxy-3-methylglutaryl-CoA | hmdbid:HMDB01375 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Pyruvate metabolism | ||
| Fatty acid metabolism | ||
| Sterol biosynthesis | ||
| Acetoacetate | hmdbid:HMDB00060 | |
| Fatty acid beta-oxidation | ||
| Glycolysis | ||
| (HMG-CoA cycle) | ||
| * pathway-regulated enzymes: HMG-CoA synthase, mt |
| Cd3g | uniprot |
| Cd3e | uniprot |
| Cd3d | uniprot |
| Cd3e | uniprot |
| Cd5 | uniprot |
| Ptpn6 | uniprot |
| Ptk2b | uniprot |
| Nck1 | |
| Sla | uniprot |
| Syk | uniprot |
| RGD1561386 | |
| Pik3r1 | uniprot |
| Pik3r2 | uniprot |
| MGC125004 | |
| MGC108827 | |
| Gab2 | uniprot |
| Shc1 | uniprot |
| PRKCQ | uniprot |
| Vav1 | uniprot |
| RGD1563421 | |
| RGD1560049 | |
| Ptpn3 | |
| Ptpn12 | uniprot |
| Map2k1 | uniprot |
| Mapk1 | uniprot |
| Prkd2 | uniprot |
| LOC500449 | |
| Ptpn11 | uniprot |
| MAP3K1 | uniprot |
| Ptprh | |
| Map2k2 | uniprot |
| Mapk3 | uniprot |
| RGD1565941 | |
| Vav2 | uniprot |
| Stat1 | uniprot |
| Stat5a | uniprot |
| MAPK7 | uniprot |
| Jak3 | uniprot |
| Sh2d3c | uniprot |
| Bcl10 | uniprot |
| Pak1 | uniprot |
| Scap1 | |
| Scap2 | |
| SOS2 | uniprot |
| Dbnl | uniprot |
| Rasa1 | uniprot |
| Ptpn22 | uniprot |
| Crkl | uniprot |
| Ctnnb1 | uniprot |
| Cblb | uniprot |
| SHB | uniprot |
| Src | uniprot |
| Ptk2 | uniprot |
| Akt1 | uniprot |
| Cd4 | uniprot |
| Cd8a | uniprot |
| Sh3bp2 | uniprot |
| Stat5b | uniprot |
| Cd2 | uniprot |
| Rap1a | uniprot |
| Lyn | |
| Rac2 | uniprot |
| Cd3z | uniprot |
| Cd3z | uniprot |
| Fyn | uniprot |
| Map4k1 | uniprot |
| Muc1 | uniprot |
| Tubb5 | uniprot |
| FCRL3 | |
| RGD1562071 | |
| CARD11 | uniprot |
| Waspip | uniprot |
| Nfam1 | uniprot |
| Def6 | chemical |
| WAS | |
| Grap | uniprot |
| Grap2 | uniprot |
| Lcp2 | uniprot |
| Arhgdib | uniprot |
| Crk | uniprot |
| DTX1 | uniprot |
| Nedd9 | uniprot |
| Rapgef1 | chemical |
| Pstpip1 | uniprot |
| Lat | uniprot |
| Grb2 | uniprot |
| Sos1 | uniprot |
| Plcg1 | uniprot |
| Pxn | uniprot |
| Arhgef7 | uniprot |
| Txk | uniprot |
| Khdrbs1 | uniprot |
| Norp | chemical |
| Unc119 | uniprot |
| Tuba4 | uniprot |
| Itk | uniprot |
| Dnm2 | uniprot |
| Dlgh1 | uniprot |
| Creb1 | uniprot |
| Crebbp | uniprot |
| arhgef6 | uniprot |
| Git2 | uniprot |
| Vasp | uniprot |
| Enah | uniprot |
| Evl | uniprot |
| Cdc42 | uniprot |
| RGD1563421 | |
| Lcp2 | uniprot |
| Nck1 | |
| Ptprc | uniprot |
| Sh2d2a | uniprot |
| WASF2 | uniprot |
| Abi1 | uniprot |
| PAG1 | uniprot |
| Rasgrp2 | |
| Cd2ap | uniprot |
| Homer3 | uniprot |
| Cebpb | uniprot |
| Ppp3cb | uniprot |
| Cabin1 | uniprot |
| Nfatc2 | uniprot |
| Itpr1 | uniprot |
| Ywhaq | uniprot |
| Jun | uniprot |
| Jun | uniprot |
| Fos | uniprot |
| Cish | uniprot |
| Dock2 | uniprot |
| Ripk2 | uniprot |
| RGD1562795 | |
| Acp1 | uniprot |
| LNK | uniprot |
| Stk39 | uniprot |
| Ptprj | uniprot |
| Hdac7a | uniprot |
| Stat5a | uniprot |
| Stat5b | uniprot |
| RGD1562795 | |
| Hdac7a | uniprot |
| Braf | uniprot |
| TRA@ | |
| TRB@ | |
| Zap70 | uniprot |
| Lck | uniprot |
| Abl1 | uniprot |
| Antigen | |
| Molecular association | |
| Methylation | chemical |
| Glycosylation | |
| Autophosphorylation | chemical |
| Demethylation | chemical |
| Translocation | |
| Cytoplasm | |
| Endoplasmic reticulum | |
| Endosome | |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| NU->CY | |
| D | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Accession Number: NetPath_11 | |
| ER | |
| CY | |
| EN | |
| Acetylation | chemical |
| Deacetylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| EC | |
| Extracellular | |
| Golgi apparatus | |
| GO | |
| Mitochondrion | |
| MT | |
| Nucleus | CHEBI:33252 |
| NU | |
| Plasma membrane | |
| PM |
| Tgfb1 | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Smad2 | uniprot |
| Dab2 | uniprot |
| Madh7 | uniprot |
| SMURF1 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfb2 | uniprot |
| Arrb2 | uniprot |
| Tgfb3 | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Smad3 | uniprot |
| Strap | |
| Smad6 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfb1 | uniprot |
| Acvrl1 | uniprot |
| Sparc | |
| Sdc2 | uniprot |
| Cd44 | uniprot |
| Ap2b1 | uniprot |
| Smad4 | uniprot |
| Zfyve9 | |
| Daxx | uniprot |
| Fkbp1a | uniprot |
| Fnta | uniprot |
| ERBB2IP | uniprot |
| Gipc1 | uniprot |
| Pik3r1 | uniprot |
| Ctnnb1 | uniprot |
| ENG | uniprot |
| Cav | uniprot |
| EIF3S2 | uniprot |
| Axin1 | uniprot |
| Snx6 | uniprot |
| Vdr | uniprot |
| Prkar2a | uniprot |
| Prkar1b | uniprot |
| Tcf8 | uniprot |
| Tgif | uniprot |
| RGD1304977 | |
| Pik3r2 | uniprot |
| Pard3 | uniprot |
| Hgs | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr1 | uniprot |
| Tgfb1 | uniprot |
| Tgfb3 | uniprot |
| Tgfb2 | uniprot |
| Tgfb2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfb1 | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr3 | uniprot |
| Tgfbr2 | uniprot |
| Tgfb3 | uniprot |
| Tgfb3 | uniprot |
| Lef1 | uniprot |
| Hdac1 | uniprot |
| RGD1563119 | |
| MEF2A | uniprot |
| Runx2 | uniprot |
| Myc | uniprot |
| Sp1 | uniprot |
| Nup153 | uniprot |
| Smad2 | uniprot |
| Nfyc | uniprot |
| Snip1 | uniprot |
| Zfhx1b | uniprot |
| Foxh1 | uniprot |
| PCAF | uniprot |
| Ep300 | |
| Cdc27 | uniprot |
| Skil | uniprot |
| Esr1 | uniprot |
| Smad4 | uniprot |
| Smad3 | uniprot |
| Rbx1 | uniprot |
| Cul1 | uniprot |
| Dvl1 | uniprot |
| Foxo3a | |
| Tp53 | uniprot |
| Trp73 | |
| RGD1561926 | |
| CRI2 | |
| STAMBPL1 | uniprot |
| Foxo1a | uniprot |
| Atf2 | uniprot |
| Cited1 | uniprot |
| Jund | uniprot |
| Fos | uniprot |
| RBL1 | uniprot |
| Anapc10 | uniprot |
| Anapc1 | uniprot |
| Anapc4 | uniprot |
| Cdc27 | uniprot |
| Cdc16 | uniprot |
| CDC23 | uniprot |
| Anapc2 | uniprot |
| Anapc5 | uniprot |
| Anapc7 | uniprot |
| E2f5 | uniprot |
| Hnf4a | uniprot |
| E2F4 | uniprot |
| Anapc1 | uniprot |
| Anapc2 | uniprot |
| Anapc5 | uniprot |
| Anapc7 | uniprot |
| Cdc27 | uniprot |
| Cdc16 | uniprot |
| CDC23 | uniprot |
| Anapc4 | uniprot |
| Jun | uniprot |
| Smad3 | uniprot |
| SKI | uniprot |
| Ar | |
| Ctcf | uniprot |
| Atf3 | uniprot |
| Esr1 | uniprot |
| Ets1 | uniprot |
| Axin2 | uniprot |
| RGD1561201 | |
| Junb | uniprot |
| Fosb | uniprot |
| Trap1 | uniprot |
| Stk11ip | |
| Stk11 | uniprot |
| Sumo1 | uniprot |
| Dcp1a | uniprot |
| Cops5 | uniprot |
| Mapk14 | uniprot |
| Map3k7 | uniprot |
| Madh7 | uniprot |
| SMURF1 | uniprot |
| Yap1 | uniprot |
| Map2k6 | uniprot |
| Map2k3 | uniprot |
| Smurf2 | |
| Madh7 | uniprot |
| Smurf2 | |
| Strap | |
| Snx6 | uniprot |
| Snx1 | uniprot |
| Snx2 | uniprot |
| Snx4 | uniprot |
| CDK2 | uniprot |
| Ccne1 | uniprot |
| TFDP1 | uniprot |
| Smad3 | uniprot |
| Tcfdp2 | chemical |
| Cdkn1a | uniprot |
| Nfya | uniprot |
| Nfyb | uniprot |
| Foxg1 | uniprot |
| Crebbp | uniprot |
| Ncoa1 | uniprot |
| Fzr1 | uniprot |
| Rbl2 | uniprot |
| Ppp2r2a | uniprot |
| Anapc10 | uniprot |
| Rock1 | uniprot |
| Cdc25a | uniprot |
| MAP3K7IP1 | uniprot |
| Xpo1 | uniprot |
| Hspa8 | uniprot |
| Rock1 | uniprot |
| Rbl2 | uniprot |
| E2F4 | uniprot |
| E2F4 | uniprot |
| E2F4 | uniprot |
| RBL1 | uniprot |
| Kpnb1 | uniprot |
| Smad3 | uniprot |
| Kpnb1 | uniprot |
| Smad3 | uniprot |
| Tcfdp2 | chemical |
| Tcfdp2 | chemical |
| Smad4 | uniprot |
| Smad4 | uniprot |
| Dcp1a | uniprot |
| Smad2 | uniprot |
| Smad2 | uniprot |
| Rb1 | uniprot |
| Rb1 | uniprot |
| Mapk8 | uniprot |
| Cdk6 | uniprot |
| Cdk4 | uniprot |
| Ccnd1 | uniprot |
| Prkcd | uniprot |
| Prkcc | uniprot |
| Prkcb1 | uniprot |
| Rb1 | uniprot |
| Pias1 | uniprot |
| Miz1 | uniprot |
| Ubc2e | |
| Ube2d1 | uniprot |
| Ube2d3 | uniprot |
| Skp1a | uniprot |
| Btrc | chemical |
| Rbx1 | uniprot |
| Cul1 | uniprot |
| Camk2a | uniprot |
| Camk2d | uniprot |
| Camk2g | uniprot |
| Camk2b | uniprot |
| E2f5 | uniprot |
| Skp1a | uniprot |
| Cul1 | uniprot |
| Rbx1 | uniprot |
| Btrc | chemical |
| Smad3 | uniprot |
| RBL1 | uniprot |
| Smad4 | uniprot |
| Smad3 | uniprot |
| E2F4 | uniprot |
| E2f5 | uniprot |
| TFDP1 | uniprot |
| RBL1 | uniprot |
| Smad4 | uniprot |
| E2F4 | uniprot |
| TFDP1 | uniprot |
| Smad3 | uniprot |
| E2f5 | uniprot |
| E2f5 | uniprot |
| E2f5 | uniprot |
| RBL1 | uniprot |
| Cdc2a | uniprot |
| Ccnb2 | uniprot |
| Mapk14 | uniprot |
| Mapk8 | uniprot |
| Gene Symbol | |
| Hoxa7 | uniprot |
| NU -> CY | |
| NU -> CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| CY | |
| NU | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| NU | |
| CY | |
| CY | |
| NU | |
| Receptor | |
| Ligand | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Molecular association | |
| (Protein-protein interaction) | |
| D | |
| Reaction through unknown mechanisms/molecules | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Sumoylation | chemical |
| Desumoylation | |
| Ubiquitination | |
| Deubiquitination | |
| Activation | chemical |
| Inhibition | chemical |
| Recruitment | |
| Control | |
| Translocation | |
| CY | |
| Cytoplasm | |
| EC | |
| Extracellular | |
| EN | |
| Endosome | |
| ER | |
| Endoplasmic reticulum | |
| GO | |
| Golgi apparatus | |
| MT | |
| Mitochondria | |
| NU | |
| Nucleus | CHEBI:33252 |
| PM | |
| Plasma membrane | |
| Accession Number: NetPath_7; cellmap:7 |
| Tgfbr3 | uniprot |
| Eng | uniprot |
| Tgfbr2 | uniprot |
| Tgfbr1 | uniprot |
| Fkbp1a | uniprot |
| Bambi | uniprot |
| Ifng | uniprot |
| Tgfb1 | uniprot |
| Bmp4 | uniprot |
| Tnf | uniprot |
| Egf | uniprot |
| Stat1 | uniprot |
| Madh2 | uniprot |
| Smad1 | uniprot |
| Nfkb1 | uniprot |
| Tgfb1 | uniprot |
| Inhba | uniprot |
| Bmp4 | uniprot |
| Smad6 | uniprot |
| Madh7 | uniprot |
| Smad5 | uniprot |
| Madh9 | uniprot |
| Smad1 | uniprot |
| Madh2 | uniprot |
| Madh3 | uniprot |
| Madh4 | uniprot |
| Mapk3 | uniprot |
| RAS | uniprot |
| Tgfbr1 | uniprot |
| Tgfbr2 | uniprot |
| Sara | |
| Nog | uniprot |
| Fst | uniprot |
| Ltbp1 | uniprot |
| RGD:1303119 | |
| Thbs1 | uniprot |
| Wnt1 | uniprot |
| Lif | uniprot |
| Tnf | uniprot |
| Catnb | uniprot |
| Jak1 | uniprot |
| Mapk9 | uniprot |
| Spp1 | uniprot |
| Sip1 | uniprot |
| Runx2 | uniprot |
| Runx3 | uniprot |
| Lef1 | uniprot |
| Stat3 | uniprot |
| Jun | uniprot |
| Tfe3 | uniprot |
| Fast | |
| QAZ | |
| P300 | uniprot |
| Crebbp | uniprot |
| Tgif | uniprot |
| SNO-N | |
| SKI | uniprot |
| Serpine1 | uniprot |
| Fos | uniprot |
| ligands: | |
| Co-smads | |
| Repressors | |
| Cofactors | CHEBI:23357 |
| Rsmads | |
| R-Smads | |
| Cofactor | CHEBI:23357 |
| Accessory receptors | |
| TGFb | |
| Co-Smads |
| Traf6 | uniprot |
| Flna | uniprot |
| Psmc3 | uniprot |
| Rel | uniprot |
| Nfkb1 | uniprot |
| Rp1h | uniprot |
| Ikbkg | uniprot |
| LOC299827 | |
| TBKBP1 | |
| Traf2 | uniprot |
| Tradd | chemical |
| Psmd7 | uniprot |
| Psmd3 | uniprot |
| Psmd12 | uniprot |
| Nfkb2 | uniprot |
| Psmd13 | uniprot |
| LOC310877 | |
| Psmd1 | uniprot |
| Rpl30 | uniprot |
| RELB | uniprot |
| Smarcc1 | uniprot |
| Cdc37 | uniprot |
| RPL6 | uniprot |
| Smarca4 | |
| Hdac1 | uniprot |
| Hdac2 | uniprot |
| Kcnq1 | uniprot |
| Kpna3 | uniprot |
| Psmb5 | uniprot |
| Faf1 | uniprot |
| Psmc1 | uniprot |
| Stat1 | uniprot |
| Fadd | uniprot |
| Psmc2 | uniprot |
| Papola | uniprot |
| BCL3 | uniprot |
| RGD1562602 | |
| IQGAP2 | uniprot |
| Ddx3x | uniprot |
| Glg1 | uniprot |
| Usp11 | uniprot |
| BCL7A | uniprot |
| Gsk3b | uniprot |
| Smarcb1 | uniprot |
| TRAF1 | uniprot |
| LOC299827 | |
| Cops3 | uniprot |
| Hdac6 | uniprot |
| SMARCC2 | uniprot |
| Unc5cl | chemical |
| Pkn1 | uniprot |
| KPNA2 | uniprot |
| Kpna6 | uniprot |
| TAB3 | uniprot |
| Pias3 | uniprot |
| PEG3 | uniprot |
| Cav | uniprot |
| Gtf2i | uniprot |
| TXLNA | uniprot |
| Map3k3 | uniprot |
| Ywhag | uniprot |
| Gab1 | uniprot |
| PFDN2 | uniprot |
| Ywhab | uniprot |
| Ywhae | uniprot |
| Ywhah | uniprot |
| Ywhaq | uniprot |
| Ywhaz | uniprot |
| TNFAIP3 | uniprot |
| Tnip1 | uniprot |
| Tnip2 | |
| Akt2 | uniprot |
| Chuk | uniprot |
| Akt1 | uniprot |
| Src | uniprot |
| Rnf25 | uniprot |
| Nfkb1 | uniprot |
| Rela | uniprot |
| Fbxw11 | |
| Csnk2a1 | uniprot |
| Csnk2a2 | uniprot |
| Csnk2b | uniprot |
| Ripk1 | uniprot |
| CASP10 | uniprot |
| Casp8 | uniprot |
| Traf3 | uniprot |
| Birc2 | uniprot |
| Birc3 | uniprot |
| Ptk2 | uniprot |
| Cflar | uniprot |
| Casp3 | uniprot |
| Nfkbia | uniprot |
| Cul1 | uniprot |
| Skp1a | uniprot |
| Btrc | chemical |
| RGD1309571 | |
| Rela | uniprot |
| ASE1 | uniprot |
| Nfkbib | uniprot |
| Lrpprc | |
| RGD1561988 | |
| Mtif2 | uniprot |
| Nkiras1 | uniprot |
| Nkiras2 | uniprot |
| Pdcd2 | uniprot |
| Rpo1-4 | uniprot |
| Rpo1-2 | uniprot |
| POLR1D | uniprot |
| POLRY2H | |
| RGD1564685 | |
| Ikbkb | uniprot |
| RGD1309922 | |
| Ikbkg | uniprot |
| Chuk | uniprot |
| Rasal2 | |
| Praf1 | uniprot |
| Rpo1-1 | uniprot |
| Slc35b2 | uniprot |
| Nfkbia | uniprot |
| COMMD1 | uniprot |
| Mcm5 | uniprot |
| Mcm7 | uniprot |
| Sumo1 | uniprot |
| Ikbkap | chemical |
| Hspcb | uniprot |
| Zfp216 | uniprot |
| Crebbp | uniprot |
| Fkbp5 | uniprot |
| Hspca | uniprot |
| Ptpn11 | uniprot |
| Map3k14 | uniprot |
| Fbl | uniprot |
| Rpl4 | uniprot |
| KTN1 | uniprot |
| Rpl8 | uniprot |
| Rps11 | uniprot |
| RPS13 | uniprot |
| TRAF5 | uniprot |
| Azi2 | |
| Ikbke | uniprot |
| Tank | |
| MAP3K1 | uniprot |
| Wdr68 | uniprot |
| Ube2i | uniprot |
| Map3k8 | uniprot |
| Map3k3 | uniprot |
| Map2k5 | uniprot |
| Mark2 | uniprot |
| Rps6ka5 | uniprot |
| Nfkbiz | |
| Usp2 | uniprot |
| Nsmaf | uniprot |
| Gnb2l1 | uniprot |
| NALP4 | uniprot |
| Cradd | uniprot |
| Casp2 | uniprot |
| RGD1563614 | |
| Akap8 | uniprot |
| Actl6a | uniprot |
| PPP1R13L | uniprot |
| Dpf2 | uniprot |
| Ripk3 | uniprot |
| Ripk2 | uniprot |
| Pebp1 | uniprot |
| Nr2c2 | uniprot |
| Nr2c2 | uniprot |
| MAP3K7IP1 | uniprot |
| Map3k7ip2 | uniprot |
| Alpl | uniprot |
| Tnfrsf1a | uniprot |
| Tnf | uniprot |
| Dap | uniprot |
| Fancd2 | uniprot |
| Birc2 | uniprot |
| Traf2 | uniprot |
| Ripk1 | uniprot |
| Tradd | chemical |
| Tnfrsf1b | uniprot |
| Birc3 | uniprot |
| TRAF1 | uniprot |
| Traf2 | uniprot |
| Bag4 | uniprot |
| Rps6kb1 | uniprot |
| Traf4 | uniprot |
| Psmd6 | uniprot |
| Traip | uniprot |
| Trpc4ap | uniprot |
| RGD1565135 | |
| Tnfrsf8 | uniprot |
| Casp8ap2 | uniprot |
| Hspb1 | uniprot |
| Tnfrsf1b | uniprot |
| Tnfrsf1b | uniprot |
| Tnfrsf1a | uniprot |
| Tnfrsf1a | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Tnf | uniprot |
| Prkcz | uniprot |
| Rela | uniprot |
| Gene | |
| Gene | |
| Gene | |
| Gene | |
| Prkaca | uniprot |
| Ppp2ca | uniprot |
| Ube2d3 | uniprot |
| HIST3H3 | uniprot |
| Ubc2e | |
| Casp7 | uniprot |
| Map3k2 | uniprot |
| Capn3 | uniprot |
| CDC34 | uniprot |
| Nfkbia | uniprot |
| RELB | uniprot |
| Rela | uniprot |
| Rel | uniprot |
| Traf4 | uniprot |
| Nfkb1 | uniprot |
| Gene Symbol | |
| RGD1304726 | |
| NU | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme complex | |
| Molecular association | |
| (Protein-protein interaction) | |
| Reaction through unknown mechanisms/molecules | |
| D | |
| Autophosphorylation | chemical |
| Acetylation | chemical |
| Deacetylation | chemical |
| Glycosylation | |
| Methylation | chemical |
| Demethylation | chemical |
| Palmitoylation | chemical |
| CY | |
| EC | |
| EN | |
| ER | |
| GO | |
| MT | |
| PM | |
| Phosphorylation | chemical |
| Dephosphorylation | chemical |
| Proteolytic cleavage | |
| Ubiquitination | |
| Inhibition | chemical |
| CY ->NU | |
| CY ->NU | |
| CY ->NU | |
| CY ->NU | |
| CY ->NU | |
| Receptor | |
| Ligand | |
| Sumoylation | chemical |
| Desumoylation | |
| Deubiquitination | |
| Activation | chemical |
| Recruitment | |
| Control | |
| Translocation | |
| Cytoplasm | |
| Extracellular | |
| Endosome | |
| Endoplasmic reticulum | |
| Golgi apparatus | |
| Mitochondrion | |
| Nucleus | CHEBI:33252 |
| Plasma membrane | |
| Accession Number: NetPath_9; cellmap:9 |
| Etf1 | uniprot |
| eRF3 | |
| Eef1a1 | uniprot |
| Stnl | uniprot |
| Eef1b2 | uniprot |
| RGD:1302939 | |
| Eef1d | uniprot |
| Eef2 | uniprot |
| Eef2k | uniprot |
| eIF6 | uniprot |
| Eif5 | uniprot |
| Pabpc1 | uniprot |
| Pabpc2 | chemical |
| Pabpc3 | chemical |
| Eif5a | uniprot |
| Eif4g2 | uniprot |
| Eif4e | uniprot |
| eIF1 | uniprot |
| eIF4A-I | uniprot |
| eIF4A-II | uniprot |
| eIF4H | uniprot |
| Eif4b | uniprot |
| LOC497887 | |
| Eif4ebp1 | uniprot |
| Eif4ebp2 | uniprot |
| Eif4ebp3 | uniprot |
| Eif2ak1 | uniprot |
| Prkr | uniprot |
| Eif2ak3 | uniprot |
| Eif2b1 | uniprot |
| Eif2b2 | uniprot |
| Eif2b3 | uniprot |
| Eif2b4 | uniprot |
| Eif2b5 | uniprot |
| Eif2s1 | uniprot |
| Eif2b4 | uniprot |
| Eif2s3 | uniprot |
| Eif2s3y | uniprot |
| LOC302697 | |
| Eif3s1 | uniprot |
| Eif3s2 | uniprot |
| RGD:735178 | |
| Eif3s4 | uniprot |
| Eif3s5 | uniprot |
| Eif3s6 | uniprot |
| RGD:1303255 | |
| Eif3s8 | uniprot |
| Eif3s9 | uniprot |
| Eif3s10 | uniprot |
| AUG | |
| mRNA | CHEBI:33699 |
| Guanine Nucleotide Exchange | |
| Recruitment of 43S | |
| scanning | |
| Cap Binding Complex | |
| 43S Pre-initiation Complex | |
| Recruitment of 60S subunit | |
| and first peptide bond | |
| 60S Subunit | |
| 40S Subunit | |
| Pre-initiation Complex | |
| Translocation | |
| Binds aminoacyl-tRNA | |
| Termination | chemical |
| Elongation | |
| Initiation | chemical |
| m7G | |
| AAAAAAAAAAAAAAA |
| Gpd1 | uniprot |
| Gyk | uniprot |
| Gpam | uniprot |
| Gnpat | uniprot |
| Agps | uniprot |
| AYR1 | uniprot |
| Agpat1 | uniprot |
| Agpat2 | uniprot |
| Agpat3 | uniprot |
| Agpat4 | uniprot |
| Agpat5 | uniprot |
| Ppap2a | uniprot |
| Ppap2b | uniprot |
| Ppap2c | uniprot |
| Dgat1 | uniprot |
| Gk2 | |
| Dgat2 | uniprot |
| Mgat1 | uniprot |
| Mgat2 | uniprot |
| Mgat3 | uniprot |
| Lpl | uniprot |
| Lipe | uniprot |
| Lipc | uniprot |
| Lipf | uniprot |
| Pnpla2 | chemical |
| Dihydroxyacetonephosphate | hmdbid:HMDB01473 |
| Glycerol | hmdbid:HMDB00131 |
| Glycerol-3-phosphate | hmdbid:HMDB00126 |
| Fatty Acyl CoA | |
| See Fatty Acid Synthesis MAPP | |
| Lysophosphatic Acid | chemical |
| Dihydroxyacetone phosphate | hmdbid:HMDB01473 |
| Fatty acyl CoA | |
| acyldihydroxyacetonephosphate | chemical |
| See Fatty Acid Synthesis MAPP | |
| Phosphatic acid | chemical |
| Only 1 of these enzymes is needed | |
| Diacylglycerol | CHEBI:18035 CHEBI:18035 |
| Only 1 of these enzymes is needed | |
| Triacylglycerol | chemical |
| Fatty Acyl CoA | |
| Monoacylglycerol | CHEBI:17408 CHEBI:17408 |
| Degradation | |
| Path |
| 2.6.1.27 | ||
| 1.4.3.2 | ||
| Indo | ||
| Cyp2j4 | ||
| Asmt | chemical | |
| Hrmt1l2 | uniprot | |
| Aanat | uniprot | |
| Indo | ||
| Mdm2 | uniprot | |
| Maob | uniprot | |
| Ddc | uniprot | |
| 2.6.1.27 | ||
| Ddc | uniprot | |
| Indo | ||
| 2.6.1.27 | ||
| 1.13.11.17 | ||
| 1.7.3.2 | ||
| 1.14.16.- | ||
| 3.5.1.49 | ||
| 3.5.1.9 | ||
| 1.13.11.23 | ||
| 1.14.16.3 | ||
| Acat1 | uniprot | |
| Hsd17b10 | uniprot | |
| Echs1 | uniprot | |
| Gcdh | uniprot | |
| LOC360975 | ||
| 1.2.1.32 | ||
| Acmsd | uniprot | |
| Haao | uniprot | |
| Kynu | uniprot | |
| 1.14.13.9 | ||
| Kynu | uniprot | |
| Kynu | uniprot | |
| Tdo2 | uniprot | |
| 4.1.99.1 | ||
| Tph | uniprot | |
| Wars | ||
| 1.13.99.3 | ||
| Cat | ||
| Aadat | uniprot | |
| Aadat | uniprot | |
| 1.10.3.4 | ||
| Maob | uniprot | |
| 1.13.11.- | ||
| 1.5.1.- | ||
| Dhcr24 | ||
| 1.13.11.10 | ||
| 1.3.1.18 | ||
| 1.14.99.2 | ||
| 1.13.12.3 | ||
| Ddc | uniprot | |
| Maob | uniprot | |
| 4.1.1.43 | ||
| 1.2.3.7 | ||
| Aldh3a2 | uniprot | |
| 2.1.1.47 | ||
| 1.1.1.110 | ||
| Cyp7b1 | uniprot | |
| Afmid | uniprot | |
| Aldh3a2 | uniprot | |
| Aox1 | uniprot | |
| 1.2.1.- | ||
| Dd5 | uniprot | |
| Hrmt1l2 | uniprot | |
| Hrmt1l2 | uniprot | |
| Maob | uniprot | |
| 4.2.1.84 | ||
| 3.5.1.4 | ||
| 3.5.5.1 | ||
| 3.2.1.147 | ||
| 1.1.1.190 | ||
| 1.1.1.191 | ||
| Abp1 | uniprot | |
| 2.1.1.49 | ||
| LOC368066 | ||
| 3.5.99.5 | ||
| Cyp1a1 | uniprot | |
| Cyp1a2 | uniprot | |
| Cyp2a3a | uniprot | |
| Cyp2a1 | uniprot | |
| Cyp2a2 | uniprot | |
| Cyp2c40 | uniprot | |
| Cyp2d26 | uniprot | |
| Cyp2e1 | uniprot | |
| Cyp19a1 | uniprot | |
| Cyp1b1 | uniprot | |
| Cyp3a3 | ||
| Cyp2c | uniprot | |
| Cyp2b15 | uniprot | |
| Cyp2c7 | uniprot | |
| Cyp2f2 | uniprot | |
| Cyp4f2 | uniprot | |
| Hadhsc | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh2 | uniprot | |
| Aldh1a4 | uniprot | |
| Aldh9a1 | uniprot | |
| Aldh1a2 | uniprot | |
| Aldh1a1 | uniprot | |
| Aldh1a4 | uniprot | |
| Aldh2 | uniprot | |
| Aldh9a1 | uniprot | |
| 4.1.1.- | ||
| Mdm2 | uniprot | |
| Mdm2 | uniprot | |
| Ube3a | uniprot | |
| Ube3a | uniprot | |
| Rnf25 | uniprot | |
| Rnf25 | uniprot | |
| Asmt | chemical | |
| Gcdh | uniprot | |
| Nicotinate and nicotinamide metabolism | ||
| PhenylAla, Tyr and Trp biosynthesis | ||
| Glycolysis / Gluconeogenesis | ||
| Benzoate degradation via hydroxylation | ||
| Benzoate degradation via hydroxylation | ||
| 6-Hydroxykynurenate | chemical | |
| 4,6-Dihydroxyquinoline | hmdbid:HMDB04077 | |
| 4-(2-Amino-5-hydroxyphenyl) | chemical | |
| 5-Hydroxykynurenamine | CHEBI:28715 | |
| 5-Hydroxykynurenine | CHEBI:2076 | |
| 5-Hydroxy-N-formylkynurenine | CHEBI:2065 | |
| N-Acetylisatin | CHEBI:16050 | |
| N-Acetylindoxyl | CHEBI:15363 | |
| Indoxyl | hmdbid:HMDB04094 | |
| 2,3-Dihydroxyindole | CHEBI:17828 | |
| 2-Oxoglutarate | hmdbid:HMDB00208 | |
| Oxaloacetate | hmdbid:HMDB00223 | |
| 5-(2’-Carboxyethyl)-4,6-dihydroxypicolinate | chemical | |
| 5-(2’-Formylethyl)-4,6-dihydroxypicolinate | chemical | |
| 5-(3’-Carboxy-3’-oxopropyl) | chemical | |
| 5-(3’-Carboxy-3’-oxopropenyl)-4,6-dihydroxypicolin | chemical | |
| 7,8-Dihydroxykynurenate | CHEBI:17508 | |
| 7,8-Dihydro-7,8-dihydroxykynurenate | CHEBI:17109 | |
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot |
| Kynurenate | hmdbid:HMDB00715 | |
| 4-(2-Aminophenyl)-2,4-dioxobutanoate | hmdbid:HMDB00978 | |
| L-Kynurenine | hmdbid:HMDB00183 | |
| Formylkynurenine | hmdbid:HMDB01200 | |
| Indole | hmdbid:HMDB00738 | |
| 2-Formylaminobenzaldehyde | CHEBI:18033 | |
| 3-Indoleglycolaldehyde | CHEBI:15976 | |
| Indole-3-acetamide | CHEBI:16031 | |
| 5-Hydroxyindolepyruvate | CHEBI:27597 | |
| 5-Hydroxy | chemical | |
| L-Tryptophan | hmdbid:HMDB00929 | |
| C00332 | ||
| C01144 | ||
| C00877 | ||
| C00527 | ||
| 2-Oxoadipate | hmdbid:HMDB00225 | |
| 2-Aminomuconate | hmdbid:HMDB01241 | |
| 2-Aminomuconate | hmdbid:HMDB01241 | |
| Quinolinate | hmdbid:HMDB00232 | |
| 2-Amino-3-carboxymuconate | chemical | |
| 3-Hydroxyanthranilate | hmdbid:HMDB01476 | |
| Xanthurenic | chemical | |
| 4-(2-Amino-3-hydroxyphenyl) | chemical | |
| 4,8-Dihydroxyquinoline | CHEBI:28883 | |
| 3-Hydroxykynurenamine | CHEBI:27421 | |
| 3-Hydroxy- | chemical | |
| Isophenoxazine | CHEBI:17293 | |
| 2-Aminophenol | CHEBI:18112 | |
| Cinnavalininate | chemical | |
| L-Tryptophanyl-tRNA | chemical | |
| 3-(2-Aminoethyl) | chemical | |
| 5-Hydroxyindoleacetaldehyde | hmdbid:HMDB04073 | |
| 5-Hydroxyindoleacetate | hmdbid:HMDB00763 | |
| 5-Methoxytryptamine | hmdbid:HMDB04095 | |
| Formyl-5-hydroxykynurenamine | CHEBI:28736 | |
| N-Acetylserotonin | hmdbid:HMDB01238 | |
| Melatonin | hmdbid:HMDB01389 | |
| 6-Hydroxymelatonin | hmdbid:HMDB04081 | |
| Formyl-N-acetyl-5- | chemical | |
| Indolepyruvate | CHEBI:17640 | |
| Indolelactate | hmdbid:HMDB00671 | |
| 3-Methylindolepyruvate | CHEBI:28549 | |
| 6-Hydroxyindolelactate | CHEBI:27524 | |
| Indole-3-acetate | hmdbid:HMDB00197 | |
| Indole-3-acetaldehyde | hmdbid:HMDB01190 | |
| Tryptamine | hmdbid:HMDB00303 | |
| 5-Methoxyindoleacetate | hmdbid:HMDB04096 | |
| 5-Hydroxyindoleacetylglycine | CHEBI:27631 | |
| Indole-3-ethanol | hmdbid:HMDB03447 | |
| 3-Methyldioxyindole | hmdbid:HMDB04186 | |
| 2-Formamino | chemical | |
| Indole-3-acetaldoxime | CHEBI:28311 | |
| Glucobrassicin | CHEBI:29028 | |
| 3-Methoxyanthranilate | CHEBI:20109 | |
| 8-Methoxykynurenate | chemical | |
| Anthranilate | hmdbid:HMDB01123 | |
| Anthranilate | hmdbid:HMDB01123 | |
| 3-Indoleacetonitrile | CHEBI:17566 | |
| Formylanthranilate | hmdbid:HMDB04089 | |
| N-Methylserotonin | hmdbid:HMDB04369 | |
| N-Methyltryptamine | hmdbid:HMDB04370 | |
| (Z)-5-Oxohex-2-enedioate | chemical | |
| methoxykynurenamine | chemical | |
| -1H-indol-5-ol | chemical | |
| -L-tryptophan | chemical | |
| -2,4-dioxobutanoate | chemical | |
| benzoylacetate | chemical | |
| -2,4-dioxobutanoate | chemical | |
| -4,6-dihydroxypicolinate | chemical | |
| L-kynurenine | hmdbid:HMDB00183 |
| Acadl | uniprot | ||
| Hadha | uniprot | ||
| Hadhb | uniprot | ||
| Dci | uniprot | ||
| Acadl | uniprot | ||
| Hadha | uniprot | ||
| Hadhb | uniprot | ||
| Acadm | uniprot | ||
| Decr1 | uniprot | ||
| Dci | uniprot | ||
| Linoleoyl-CoA | hmdbid:HMDB01064 | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot | |
| cis,cis-3,6-Dodecadienoyl-CoA | CHEBI:28002 | ||
| trans,cis-Lauro-2,6-dienoyl-CoA | CHEBI:28387 | ||
| 4-cis-dexeboyl-CoA | chemical | ||
| Acetyl-CoA | hmdbid:HMDB01206 | uniprot | |
| 2-trans-4-cis-decadienoyl-CoA | CHEBI:29119 | ||
| 3-trans-decenoyl-CoA | CHEBI:29126 | ||
| trans-dec-2-enoyl-CoA | CHEBI:10723 | ||
| See Beta Oxidation 2 MAPP |
| Cps1 | uniprot |
| Glud1 | uniprot |
| LOC303563 | |
| Pycs | uniprot |
| 2.7.2.8 | |
| 2.6.1.11 | |
| 1.2.1.38 | |
| Pycs | uniprot |
| 2.3.1.35 | |
| Otc | uniprot |
| Ass | |
| Oat | |
| Pycr1 | uniprot |
| Arg1 | uniprot |
| Odc1 | uniprot |
| Srm | uniprot |
| LOC363469 | |
| Asl | uniprot |
| 3.5.1.5 | |
| 1.2.1.46 | |
| 1.5.99.1 | |
| Gatm | uniprot |
| 6.3.4.6 | |
| 3.5.1.54 | |
| 3.5.1.59 | |
| 3.5.2.14 | |
| 3.5.4.21 | |
| 3.5.3.3 | |
| Gamt | uniprot |
| 3.5.2.10 | |
| 2.7.3.1 | |
| Ckm | uniprot |
| 2.6.1.69 | |
| 3.5.1.16 | |
| Acy1 | chemical |
| Arg2 | uniprot |
| Ckb | uniprot |
| Pycrl | chemical |
| LOC363469 | |
| Glutamate metabolism | |
| Ala and aspartate metabolism | |
| Pyrimidine metabolism | |
| Pro metabolism | |
| Nitrogen metabolism | |
| Amino acid metabolism | |
| D-Arg and D-ornithine metabolism | |
| Citrate cycle (TCA cycle) | |
| Arginine metabolism | |
| Purine metabolism | |
| NH3 | CHEBI:16134 |
| Carbamoyl | CHEBI:33100 |
| L-Glutamate | hmdbid:HMDB00148 |
| N-Acetyl-glutamate | hmdbid:HMDB01138 |
| L-Glutamyl | chemical |
| N-Acetyl-L-glutamate | hmdbid:HMDB01138 |
| N2-Acetyl-L-ornithine | CHEBI:16543 |
| N-Acetyl-L-glutamate | hmdbid:HMDB01138 |
| L-Aspartate | hmdbid:HMDB00191 |
| L-Citrulline | hmdbid:HMDB00904 |
| L-Ornithine | hmdbid:HMDB00214 |
| (S)-1-Pyrroline-5-carboxylate | hmdbid:HMDB01301 |
| L-Glutamate- | chemical |
| L-Proline | hmdbid:HMDB00162 |
| C03406 | |
| Spermine | hmdbid:HMDB01256 |
| Putrescine | hmdbid:HMDB01414 |
| Spermidine | hmdbid:HMDB01257 |
| Arginine | hmdbid:HMDB00517 |
| Fumarate | hmdbid:HMDB00134 |
| Urea | hmdbid:HMDB00294 |
| Formate | hmdbid:HMDB00142 |
| Formaldehyde | hmdbid:HMDB01426 |
| Urea-1-carboxylate | CHEBI:15832 |
| CO2 | CHEBI:16526 |
| Sarcosine | hmdbid:HMDB00271 |
| N-Methylhydantoin | CHEBI:16354 |
| N-Carbamoylsarcosine | CHEBI:15737 |
| Creatine | hmdbid:HMDB00064 |
| Creatinine | hmdbid:HMDB00562 |
| Guanidinoacetate | hmdbid:HMDB00128 |
| creatine-P | hmdbid:HMDB01511 |
| Phosphoguanidinoacetate | hmdbid:HMDB03705 |
| 5-semialdehyde | chemical |
| Wnt3a | uniprot |
| Wnt3 | uniprot |
| Wnt1 | uniprot |
| Wnt2 | uniprot |
| Lrp6 | uniprot |
| Wnt4 | uniprot |
| Sfrp1 | uniprot |
| Lrp5 | uniprot |
| Axin1 | uniprot |
| Gsk3b | uniprot |
| Lrp6 | uniprot |
| Dkk1 | uniprot |
| Fzd9 | uniprot |
| Dvl1 | uniprot |
| Ror2 | uniprot |
| Fzd5 | uniprot |
| Wnt7a | uniprot |
| Fzd2 | uniprot |
| Lrp1 | uniprot |
| Wnt5a | uniprot |
| Arrb2 | uniprot |
| Prkca | uniprot |
| Prkcb1 | uniprot |
| Prkcc | uniprot |
| FZD7 | uniprot |
| Magi3 | chemical |
| Fzd4 | uniprot |
| Vangl2 | uniprot |
| Mapk8 | uniprot |
| Map3k7 | uniprot |
| HIPK2 | uniprot |
| RGD1561602 | |
| MYB | uniprot |
| Fzd1 | uniprot |
| Cxxc4 | |
| Csnk1d | uniprot |
| FRAT1 | uniprot |
| Tcfe2a | uniprot |
| Tcf4 | uniprot |
| Pias4 | uniprot |
| Sumo1 | uniprot |
| DVL2 | uniprot |
| Rhoa | uniprot |
| Daam1 | uniprot |
| Csnk1e | uniprot |
| Nkd1 | |
| Brd7 | uniprot |
| Dab2 | uniprot |
| Ctnnb1 | uniprot |
| Ep300 | |
| Fhl2 | uniprot |
| Csnk2a1 | uniprot |
| Csnk2a2 | uniprot |
| Csnk2b | uniprot |
| Apc | uniprot |
| Csnk1a1 | uniprot |
| Arrb1 | uniprot |
| LOC503000 | |
| Cdc25c | uniprot |
| Cdc2a | uniprot |
| Ppp2ca | uniprot |
| Dvl3 | uniprot |
| Map1b | uniprot |
| Nr5a1 | uniprot |
| Ctbp1 | uniprot |
| Ctbp2 | uniprot |
| Pax2 | uniprot |
| Mapk8ip | uniprot |
| Tbp | uniprot |
| Axin2 | uniprot |
| SOX1 | uniprot |
| Sall1 | uniprot |
| Akt1 | uniprot |
| Apc | uniprot |
| BCL9 | uniprot |
| Pin1 | uniprot |
| Camk2a | uniprot |
| Camk2b | uniprot |
| Camk2g | uniprot |
| Camk2d | uniprot |
| Jup | uniprot |
| Rac1 | uniprot |
| Smad3 | uniprot |
| Sfrp2 | uniprot |
| Axin1 | uniprot |
| Btrc | chemical |
| Tcfap2a | uniprot |
| Arrb2 | uniprot |
| Runx2 | uniprot |
| Mark2 | uniprot |
| Cul1 | uniprot |
| Skp1a | uniprot |
| Smad4 | uniprot |
| TAX1BP3 | uniprot |
| Cdh1 | uniprot |
| Ruvbl1 | uniprot |
| FRAT2 | uniprot |
| Dlgh4 | uniprot |
| Dlgh2 | uniprot |
| Dlgh1 | uniprot |
| Ctnnb1 | uniprot |
| Gsk3b | uniprot |
| Dvl1 | uniprot |
| Apc | uniprot |
| Lef1 | uniprot |
| Lef1 | uniprot |
| Apc | uniprot |
| Map3k7 | uniprot |
| Apc | uniprot |
| Cdc2a | uniprot |
| SMT3H2 | uniprot |
| Senp2 | uniprot |
| Csnk2a1 | uniprot |
| Csnk2a2 | uniprot |
| DVL2 | uniprot |
| Dvl1 | uniprot |
| Btrc | chemical |
| Ccnd1 | uniprot |
| CRYBB2 | uniprot |
| Jun | uniprot |
| Mapk9 | uniprot |
| Fzd4 | uniprot |
| Fzd1 | uniprot |
| LOC500430 | |
| Axin1 | uniprot |
| SOX9 | uniprot |
| Wnt1 | uniprot |
| Wnt1 | uniprot |
| Wnt1 | uniprot |
| Wnt2 | uniprot |
| Wnt1 | uniprot |
| Wnt3a | uniprot |
| Mapk3 | uniprot |
| Mapk1 | uniprot |
| Raf1 | uniprot |
| Wnt4 | uniprot |
| Akt1 | uniprot |
| Fzd1 | uniprot |
| Fzd1 | uniprot |
| MGC112790 | |
| Fzd6 | uniprot |
| Ctnnb1 | uniprot |
| Molecular Association | |
| Translocation | |
| Phosphorylation | chemical |
| Autophosphorylation | chemical |
| Sumoylation | chemical |
| Desumoylation | |
| Activation | chemical |
| Inhibition | chemical |
| Acetylation | chemical |
| Ubiquitination | |
| Dephosphorylation | chemical |
| Plasma membrane | |
| PM | |
| Cytoplasm | |
| CY | |
| MT | |
| Nucleus | CHEBI:33252 |
| CY->NU | |
| CY->NU | |
| NU->CY | |
| CY->NU | |
| CY->NU | |
| CY->NU | |
| CY->PM | |
| CY->PM | |
| CY->PM | |
| D | |
| PM->CY | |
| D | |
| D | |
| D | |
| CY->PM | |
| Receptor | |
| Ligand | |
| Gene Symbol | |
| Molecule in the pathway | |
| Proteins in a complex interaction | |
| Enzyme Complex | |
| (Protein-protein interaction) | |
| Reaction through unknowm mechanisms/molecules | |
| D | |
| Accession Number: NetPath_8; cellmap:8 | |
| Demethylation | chemical |
| Methylation | chemical |
| Palmitoylation | chemical |
| Glycosylation | |
| Deacetylation | chemical |
| Golgi apparatus | |
| Endoplasmic reticulum | |
| Complex formation | |
| Deubiquitination | |
| Control | |
| Recruitment | |
| Proteolytic cleavage | |
| Extracellular | |
| Mitochondrion | |
| Endosome | |
| EN | |
| EC | |
| NU | |
| ER | |
| GO | |
| D | |
| D | |
| D | |
| D |
| Prkca | uniprot | |
| Prkcd | uniprot | |
| Prkce | uniprot | |
| Hint1 | uniprot | |
| Prkch | uniprot | |
| Prkcz | uniprot | |
| Csnk1e | uniprot | |
| Plau | uniprot | |
| Jun | uniprot | |
| Fosl1 | uniprot | |
| Ccnd3 | uniprot | |
| Ccnd2 | uniprot | |
| Ccnd1 | uniprot | |
| Myc | uniprot | |
| Tcf1 | uniprot | |
| Apc | uniprot | |
| Gsk3b | uniprot | |
| Axin1 | uniprot | |
| Pafah1b1 | uniprot | |
| Rhoa | uniprot | |
| Mapk10 | uniprot | |
| Mapk9 | uniprot | |
| Fzd2 | uniprot | |
| Fzd3 | uniprot | |
| Fzd6 | uniprot | |
| Fzd9 | uniprot | |
| Ldlr | uniprot | |
| Wnt1 | uniprot | |
| Wnt2 | uniprot | |
| Wnt2b | uniprot | |
| Wnt3 | uniprot | |
| RGD:628850 | ||
| Wnt7a | uniprot | |
| RGD:621463 | ||
| Fzd1 | uniprot | |
| Fzd5 | uniprot | |
| Wnt5a | uniprot | |
| Wnt4 | uniprot | |
| Fzd4 | uniprot | |
| Dvl1 | uniprot | |
| Catnb | uniprot | |
| Ppp2r5e | uniprot | |
| Ppp2r5c | uniprot | |
| Frat1 | uniprot | |
| Racgap1 | uniprot | |
| Apoptosis | ||
| Cytoskeleton | ||
| Phosphorylated | chemical | |
| B | ||
| -Catenin | chemical | |
| P | ||
| Nucleus | CHEBI:33252 | |
| Transcriptional Activation | ||
| -Catenin | chemical | |
| B | ||
| Recruitment to Unknown | ||
| Ubiquitin Conjugating Enzyme | enzyme | |
| Ubiquitin Tagged | ||
| Frizzled Ligands | ||
| 26S Proteasome Degradation |