LOCUS NZ_ACVX01000024 60171 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00018, whole genome shotgun sequence. ACCESSION NZ_ACVX01000024 NZ_ACVX00000000 VERSION NZ_ACVX01000024.1 GI:256005124 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 60171) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 60171) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000024. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..60171 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene <1..292 /locus_tag="ClothDRAFT_1955" CDS <1..292 /locus_tag="ClothDRAFT_1955" /inference="similar to AA sequence:KEGG:Pcar_1355" /note="KEGG: pca:Pcar_1355 putative methyl-accepting chemotaxis protein (MCP)" /codon_start=2 /transl_table=11 /product="putative methyl-accepting chemotaxis protein (MCP)" /protein_id="ZP_05430094.1" /db_xref="GI:256005125" /translation="EESAAASEELSSQAELLKRSIAKFKLKNMGKMTSNRYKEVSPEI MRMLEDYTENKQPKSYSKEENGEYSDGKETAEKDVGGLKQKILLSDSEFGKY" gene 537..3200 /locus_tag="ClothDRAFT_1956" CDS 537..3200 /locus_tag="ClothDRAFT_1956" /inference="protein motif:PFAM:PF00759" /note="PFAM: glycoside hydrolase family 9; type 3a cellulose-binding domain protein; KEGG: hch:HCH_02464 cellulase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 9" /protein_id="ZP_05430095.1" /db_xref="GI:256005126" /db_xref="InterPro:IPR001701" /db_xref="InterPro:IPR001956" /translation="MRLVNSLGRRKILLILAVIVAFSTVLLFAKLWGRKTSSTLDEVG SKTHGDLTAENKNGGYLPEEEIPDQPPATGAFNYGEALQKAIFFYECQRSGKLDSSTL RLNWRGDSGLDDGKDAGIDLTGGWYDAGDHVKFNLPMSYSAAMLGWAVYEYEDAFKQS GQYNHILNNIKWACDYFIKCHPEKDVYYYQVGDGHADHAWWGPAEVMPMERPSYKVDR SSPGSTVVAETSAALAIASIIFKKVDGEYSKECLKHAKELFEFADTTKSDDGYTAANG FYNSWSGFYDELSWAAVWLYLATNDSSYLDKAESYSDKWGYEPQTNIPKYKWAQCWDD VTYGTYLLLARIKNDNGKYKEAIERHLDWWTTGYNGERITYTPKGLAWLDQWGSLRYA TTTAFLACVYSDWENGDKEKAKTYLEFARSQADYALGSTGRSFVVGFGENPPKRPHHR TAHGSWADSQMEPPEHRHVLYGALVGGPDSTDNYTDDISNYTCNEVACDYNAGFVGLL AKMYKLYGGSPDPKFNGIEEVPEDEIFVEAGVNASGNNFIEIKAIINNKSGWPARVCE NLSFRYFINIEEIVNAGKSASDLQVSSSYNQGAKLSDVKHYKDNIYYVEVDLSGTKIY PGGQSAYKKEVQFRISAPEGTVFNPENDYSYQGLSAGTVVKSEYIPVYDAGVLVFGRE PGSASKSTSKDNGLSKATPTVKTESQPTAKHTQNPASDFKTPANQNSVKKDQGIKGEV VLQYANGNAGATSNSINPRFKIINNGTKAINLSDVKIRYYYTKEGGASQNFWCDWSSA GNSNVTGNFFNLSSPKEGADTCLEVGFGSGAGTLDPGGSVEVQIRFSKEDWSNYNQSN DYSFNPSASDYTDWNRVTLYISNKLVYGKEP" sig_peptide 537..626 /locus_tag="ClothDRAFT_1956" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.975 at residue 30" misc_feature 756..2102 /locus_tag="ClothDRAFT_1956" /note="endoglucanase; Region: PLN02420" /db_xref="CDD:178040" misc_feature 765..2063 /locus_tag="ClothDRAFT_1956" /note="Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959" /db_xref="CDD:186543" misc_feature 2136..2387 /locus_tag="ClothDRAFT_1956" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" misc_feature 2760..3008 /locus_tag="ClothDRAFT_1956" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" gene complement(3202..3636) /locus_tag="ClothDRAFT_1957" CDS complement(3202..3636) /locus_tag="ClothDRAFT_1957" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430096.1" /db_xref="GI:256005127" /translation="MQFCYGDKNHIRILEEAEFWKRQEAEHTVVIRKIVQDLEEKFTE KLDEYQKILSATEATILQYIETLNRSGYVITSELVQKIANIIEITLRQSQTFVNFLNC MAKESAAVANNLTASVVINHIVRESEYYIGIAKAYLSHVAYR" gene 3861..5063 /locus_tag="ClothDRAFT_1958" CDS 3861..5063 /locus_tag="ClothDRAFT_1958" /inference="protein motif:TFAM:TIGR00231" /note="TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; Miro domain protein; KEGG: sfu:Sfum_1843 small GTP-binding protein" /codon_start=1 /transl_table=11 /product="small GTP-binding protein" /protein_id="ZP_05430097.1" /db_xref="GI:256005128" /db_xref="InterPro:IPR002917" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR013684" /translation="MGLNETPSANRLHIGFFGKRNAGKSSVVNAVTGQNLAIVSDVKG TTTDPVYKAMELLPLGPVVIIDTPGIDDEGTLGEMRVKRSRQVLNKTDIAVLVIDATC GKSEDDEKLIELFEKKDIKYVVVYNKADLEGHEETVGDNEIYVSAKTGYNINKLKEKI ASLAVTDDITHKIVGDLISPSDFVVLVVPIDKAAPKGRLILPQQQTIRDILESDAVAI VVKENELKNTLDSLGKKPKLVITDSQAFEKVAADTPDDIYLTSFSILFARYKGNLEIA VKGAKTLDSLQDGDTVLISEGCTHHRQCDDIGTVKLPRWINNYTKKNLNFEFTSGTEF PEDLTRYKLIVHCGGCMLNEREMKYRYKCAVEQNVPITNYGILIAYVHGILKRSLQIF PDILAEIL" misc_feature 3897..5024 /locus_tag="ClothDRAFT_1958" /note="Predicted GTPases [General function prediction only]; Region: COG1160" /db_xref="CDD:31354" misc_feature 3906..4352 /locus_tag="ClothDRAFT_1958" /note="Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880" /db_xref="CDD:133256" misc_feature 3912..3935 /locus_tag="ClothDRAFT_1958" /note="G1 box; other site" /db_xref="CDD:133256" misc_feature order(3921..3938,4239..4244,4248..4250,4296..4301) /locus_tag="ClothDRAFT_1958" /note="GTP/Mg2+ binding site; other site" /db_xref="CDD:133256" misc_feature 3993..4007 /locus_tag="ClothDRAFT_1958" /note="Switch I region; other site" /db_xref="CDD:133256" misc_feature 3996..3998 /locus_tag="ClothDRAFT_1958" /note="G2 box; other site" /db_xref="CDD:133256" misc_feature order(4053..4070,4128..4130) /locus_tag="ClothDRAFT_1958" /note="Switch II region; other site" /db_xref="CDD:133256" misc_feature 4056..4067 /locus_tag="ClothDRAFT_1958" /note="G3 box; other site" /db_xref="CDD:133256" misc_feature 4239..4250 /locus_tag="ClothDRAFT_1958" /note="G4 box; other site" /db_xref="CDD:133256" misc_feature 4296..4304 /locus_tag="ClothDRAFT_1958" /note="G5 box; other site" /db_xref="CDD:133256" gene 5450..7678 /locus_tag="ClothDRAFT_1959" CDS 5450..7678 /locus_tag="ClothDRAFT_1959" /inference="protein motif:PFAM:PF00759" /note="PFAM: glycoside hydrolase family 9; type 3a cellulose-binding domain protein; cellulosome protein dockerin type I; KEGG: hch:HCH_02464 cellulase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 9" /protein_id="ZP_05430098.1" /db_xref="GI:256005129" /db_xref="InterPro:IPR001701" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MKKMGLGRFSNKFVLTVLLFFLTAVLLPSSSFESKVQAASSPRY GGAYYNYGEALQKAILFYKANRLGDLPDDYILPYRADAAMTDGQDVGLDLTGGWADAG DGIKFTHPMSYAAGQLGWAVYEYRQAFEKAGLLDDILDEIKWATDFFIKAHPEPNVLY YMCGYNDSDHSVWVPHELLDYVTDRKSFVLNPSTPGSDVAGQTAACLAIASIIFEPTD PEYAETCLTHAKQIFEFGDKYRGKNPLDVLYPSGGYLDDLAWGAVWLYIKTGDSTYLE KAKSFLPVTSLGGGHTHCWDDVSYGAALKIAQLTHDEGYAAMVEKNLDFWLPGGGITY TPGGLAWLSPWGSLRYASTAAFLAFVWADDPTVGTPSKKETYRAFAEKQINYILGDNP RKGSYVVGFGENSPKHPHHRTAHGSWVSMLEVPSFHRHILYGALVGGPSSDDSWEDDI SDYTRNEVATDYNAGFVGALAKMYDMYGGEPLENWPQPEDFRAPEDDIVEYFCRGWII YEGYGTLNLLLQVNNRSGWPPTMKDKLSVRYFMDLTEVFESGGTVDDVQISLGQNEGA KLIGLKHYRDNIYYFTVDFTGTMIMPAEWEMCEKDAHVTIKYRDGITGSNENDWSYQN LRKDPDYDATSFAGLTPYIPVYDNGVLLWGEEPPAGGDDPGSSPPPTPTEPVIVYGDL NGDGNINSTDFTMLKRAILGNPAPGTNLAAGDLNRDGNTNSTDLMILRRYLLKLIGSL PI" sig_peptide 5450..5566 /locus_tag="ClothDRAFT_1959" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.640 at residue 39" misc_feature 5561..6913 /locus_tag="ClothDRAFT_1959" /note="endoglucanase; Region: PLN02420" /db_xref="CDD:178040" misc_feature 5597..6862 /locus_tag="ClothDRAFT_1959" /note="Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959" /db_xref="CDD:186543" misc_feature <7004..7201 /locus_tag="ClothDRAFT_1959" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" misc_feature 7490..7552 /locus_tag="ClothDRAFT_1959" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 7589..7651 /locus_tag="ClothDRAFT_1959" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene complement(7802..9403) /locus_tag="ClothDRAFT_1960" CDS complement(7802..9403) /locus_tag="ClothDRAFT_1960" /inference="protein motif:PFAM:PF08757" /note="PFAM: Spore coat protein CotH; cellulosome protein dockerin type I; KEGG: sfr:Sfri_0739 spore coat assembly protein-like protein" /codon_start=1 /transl_table=11 /product="Spore coat protein CotH" /protein_id="ZP_05430099.1" /db_xref="GI:256005130" /db_xref="InterPro:IPR002105" /db_xref="InterPro:IPR014867" /translation="MRKFFKLTALTTSMMLLVVCLTGPQVWAASRPEGWTEETHGKKA TPNYSVVFPEDKVNRIDIIISPENFQRMENDVFKVFMMSNEDPIYVPATVKFNNHTWW HVGIRYKGQSTLTGAMMSMSHKYPFRLNFDKFEDDYPEIDNQRFYGFDELIFNNNWYD PSFLRDKLTSDIFRDAGIPAPRCAFYRVYVDTGNGPVYWGLYTVFEDPSDKMLEYQFE NPNGNLYKGQQAPGGDLTIFDKRGYEKKTNEKADDWSDLQALVAALNAPKTDPAKWRA DLEAVFNTDSFLKWLAINTTIVNFDTYGWVTKNHYLYQDLADNGRLVFIPWDYNLSLS STNPWGIKPPSFSLDEISRNWPLIRNLIDDPVYKHIYHTEIENTLNIYFREFNVIEKA RRLHELIRPYTVGSEGEIKGYTYLTNGEAQFNQALTQLIEHISTRHREARSYLSSVNY YTPIPERTPTPFPSPTPKKPKGDINLDGKINSTDLSALKRHILRITTLSGKQLENADV NNDGSVNSTDASILKKYIAKAIPSL" sig_peptide complement(9317..9403) /locus_tag="ClothDRAFT_1960" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 at residue 29" misc_feature complement(<8402..9253) /locus_tag="ClothDRAFT_1960" /note="Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337" /db_xref="CDD:34914" misc_feature complement(8087..9088) /locus_tag="ClothDRAFT_1960" /note="CotH protein; Region: CotH; pfam08757" /db_xref="CDD:149727" misc_feature complement(7925..7987) /locus_tag="ClothDRAFT_1960" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature complement(7826..7885) /locus_tag="ClothDRAFT_1960" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene 9755..10564 /locus_tag="ClothDRAFT_1961" CDS 9755..10564 /locus_tag="ClothDRAFT_1961" /inference="protein motif:PFAM:PF07833" /note="PFAM: copper amine oxidase domain protein; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="copper amine oxidase domain protein" /protein_id="ZP_05430100.1" /db_xref="GI:256005131" /db_xref="InterPro:IPR012854" /translation="MKKIAITILTVFMLTVFLANVGYAIDIPLRVVVNGEEVNFPDAK PFIDANGRTQTPARFIGEALGATVTWDGNAKKAVFKMNGTTLELFIGKKEYQLNGQKK QMDTEALLIEGRTFVPARYVAEAFGATVSWNAAIKTVYINMDKTGKVENEGDTREVAG FIVPKGIDLMVAGADEDSGYEAVFTISFLRKNVEKQKDDMEKILLQKFSEDTVKEIMS VVRSKVNYTDVIEERYFYDKKTDQYMYMPKSWPTRTSTITLFIYRKGDKPF" sig_peptide 9755..9829 /locus_tag="ClothDRAFT_1961" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.724 at residue 25" misc_feature 9902..10177 /locus_tag="ClothDRAFT_1961" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" gene 10610..13312 /locus_tag="ClothDRAFT_1962" CDS 10610..13312 /locus_tag="ClothDRAFT_1962" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: conserved hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430101.1" /db_xref="GI:256005132" /translation="MKRILCCIILLCILAPFLLMNAYAVSYKSAKEAIDDANDFIFQK MGYENYYLFKIGNMDINEKLAQYGSETFYNRPVFVYGDSVEASKRTTTGGRDIVKKVN GKDEYRALGYAVDGSVFPNPAFLYDNEGHAAKDKKWVKEPWNGKNIKYLYGEDGSIIK KTLSDSVLNYIKNWIQINGLTPTEVEACTGKRNYFVENAVGVPEKLKNNFEDFLYIIQ PPTEHAWGLGIAFYYWNGYNNLNYKSFLIKPFDMVADDLDVGFYTIPGSVTEGSKVLV AVKVKSHFDIDLENVSFKWNITTKDSDDKDVPLDAGKYELQFADSSNNNNQSGTVNIS AEHKEGLFYAQFKMPDRDVYIEFVINEDGKNPVESNMENNTVSTVVKAEKPINMGVKK YDLPYYALSREISYPLADQNIVVNLKKPGSGWWSGNAKVDAFNVGIDTKFLHNYQVGS PVLKDEEDDVIISLPNVIAKIQRSDFGDDPENKKWLAGNNSTDILTAALKTFYDVFVL KEYKYETKCNRHEDCEAEGCSGYVKETGYARGSRSGTAPIEVNTYVYNGKKDLNKKQY ENKIVNNYDKDFKARILWTNSPIKFNVIRYMCDLDVNGNAINWRAVPGKYEREFVQQC SADIDWNIARSMQQDYEQARKAAREGKQDKSFYNKAVFATDKNLQRYDYPIKSGYYFN PTGTYTFEITTVTYKNNQNDTEEHKKLVNALVNSFRYESNLIYVDDNGNPVNIANGSY KTLGVLTAAKNTGIGGKKLISVNRDYKKVTDEIYYDSKRTEDENKNGSHDFWKMSMEG YSLSGSLDSYNKYKYREYVAGGKVFKITETTKVTFIINEGNAKFYTHPKMPDGEYYIT VRLSDIDLSKMSGMDYSSIKDVLKGVILDRIKVNVKGSIYGDIS" sig_peptide 10610..10684 /locus_tag="ClothDRAFT_1962" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.953 at residue 25" gene 13560..14369 /locus_tag="ClothDRAFT_1963" CDS 13560..14369 /locus_tag="ClothDRAFT_1963" /inference="protein motif:PFAM:PF07833" /note="PFAM: copper amine oxidase domain protein; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="copper amine oxidase domain protein" /protein_id="ZP_05430102.1" /db_xref="GI:256005133" /db_xref="InterPro:IPR012854" /translation="MKKIAIMILIIFMSTLLLTNVGYAIDIPLRVVVNGEEVKFPDAQ PFIDANGRTQTPARFIGEALGATVTWDGNAKKAVFEKSETTLVLFIGKREYEVNGQKK QMDTEALLIEGRTFVPARYVAEAFGATVSWNAAIKTVYIDMDKTGKVEVEGDTREVAG FIVPKDIDLAVGGSKEDSNYEATFTISFLRDNVEKQKDDLEKILLQKFSEDTVKEIMS VIRTKVKDTDVIEKRYFYDKKTDQYIYLAKSWPMRGSTISLYVYKKGYKPF" sig_peptide 13560..13634 /locus_tag="ClothDRAFT_1963" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.737 at residue 25" misc_feature 13707..13982 /locus_tag="ClothDRAFT_1963" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" gene 14389..15198 /locus_tag="ClothDRAFT_1964" CDS 14389..15198 /locus_tag="ClothDRAFT_1964" /inference="protein motif:PFAM:PF07833" /note="PFAM: copper amine oxidase domain protein; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="copper amine oxidase domain protein" /protein_id="ZP_05430103.1" /db_xref="GI:256005134" /db_xref="InterPro:IPR012854" /translation="MKKIAIMILIIFMSTLLLTNVGYAIDIPLRVVVNGEEVNFPDAQ PFIDANGRTQTPARFIGEALGATVTWDGNAKKAVFEKSETTLVLFIGKREYEVNGQKK QMDTEALLIEGRTFVPARYVAEAFGATVSWNAAIKTVYINMNKTGKVENEGDTREVAG FIVPKDIDLVVGPGTKDSSYEATFTINFLKNDVEKQKDDMEKILLQKFSEDTVKEIMS VVRTKVKDTDVIEERYFYDKKTGQYMYMPKSWPLRGSTITLYIYKKGVVPF" sig_peptide 14389..14463 /locus_tag="ClothDRAFT_1964" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.737 at residue 25" misc_feature 14536..14811 /locus_tag="ClothDRAFT_1964" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" gene 15284..15946 /locus_tag="ClothDRAFT_1965" CDS 15284..15946 /locus_tag="ClothDRAFT_1965" /inference="protein motif:PFAM:PF01381" /note="PFAM: helix-turn-helix domain protein; peptidase S24 and S26 domain protein; SMART: helix-turn-helix domain protein; KEGG: mrd:Mrad2831_0361 XRE family transcriptional regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, XRE family" /protein_id="ZP_05430104.1" /db_xref="GI:256005135" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR011056" /translation="MNRLGAEIGRLRKELGITQKQLAKLVGVSEGFIIDVESGRRILN EDLIKKFSRVLRGEVGKLELYEPNQDKPEPDRNVVKVVEKPVQDIWNDALSGILMTVP VYRYKMDKAVDAKQLPIIQNKVEGFPKDKVFYLIIEDDDMSGFRILKDDLALVYKTHD IDKDGIYFVDYKGKRTVRQIKDIGNGKLLLVSNSGRLITDTIYRKDLNVLGRLIRIEI ML" misc_feature 15296..15469 /locus_tag="ClothDRAFT_1965" /note="Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093" /db_xref="CDD:28977" misc_feature order(15308..15310,15320..15322,15395..15397) /locus_tag="ClothDRAFT_1965" /note="non-specific DNA binding site; other site" /db_xref="CDD:28977" misc_feature 15314..15931 /locus_tag="ClothDRAFT_1965" /note="Predicted transcriptional regulator [Transcription]; Region: COG2932" /db_xref="CDD:32756" misc_feature order(15317..15319,15392..15394) /locus_tag="ClothDRAFT_1965" /note="salt bridge; other site" /db_xref="CDD:28977" misc_feature order(15338..15343,15374..15376,15383..15385,15395..15400) /locus_tag="ClothDRAFT_1965" /note="sequence-specific DNA binding site; other site" /db_xref="CDD:28977" misc_feature 15680..>15859 /locus_tag="ClothDRAFT_1965" /note="Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529" /db_xref="CDD:119397" misc_feature order(15704..15706,15815..15817) /locus_tag="ClothDRAFT_1965" /note="Catalytic site; other site" /db_xref="CDD:119397" gene 16247..17206 /locus_tag="ClothDRAFT_1966" CDS 16247..17206 /locus_tag="ClothDRAFT_1966" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430105.1" /db_xref="GI:256005136" /translation="MKSKRILVVLVATVMVFSLISCNLGLALYINAKAGESYKYHVET VQTVDVKQNGQKITTNQNIAFDFIATVNEVDSEGNLTVEYKYDAMKFDMDANGINESF DSKDANSDNPMAAIYNSFIGKGFTAKMTKYGEVKEIGGVDDLLNSIVDSVDLGDDEGA QNLKEKIKESLGGSFSDEAMKSYVQSAVIFPENDGMKVGDSWTANNSIKSIIDVNMTI TYTLDKIEGDTAYISVEADFKTDPSKPIEYMGMELVSDLSGTMTGDVKVNTKNGFLSE GEIIQQISGNMSLVIPAMEGIESQTLELPMESKVTITYSTTKM" sig_peptide 16247..16312 /locus_tag="ClothDRAFT_1966" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.328 at residue 22" misc_feature 16388..>17032 /locus_tag="ClothDRAFT_1966" /note="geranylgeranyl reductase; Region: ChlP; TIGR02028" /db_xref="CDD:131083" gene 17387..18646 /locus_tag="ClothDRAFT_1967" CDS 17387..18646 /locus_tag="ClothDRAFT_1967" /inference="similar to AA sequence:KEGG:AFE_2171" /note="KEGG: afr:AFE_2171 GTP-binding protein" /codon_start=1 /transl_table=11 /product="GTP-binding protein" /protein_id="ZP_05430106.1" /db_xref="GI:256005137" /translation="MLKNKQLLMALSVFLIVFTTTYAFVYYNDGLNKNNRKINDNQNI QIKHFLPNENGNNENGSENNNEEESLSSPRPERKPVKVKGLYITGTSAGNKKFMERLV NLINTTELNTVVLDVKEDGKVNYASEVESVKKIGAYHELYNVDEVIKLLHDNNIYVIG RIVCFRDNYLAGKRVDLAIKRKDGSIWRENGSIAWTNPYNKEVWRYNIDIAKEAVKKG FDEIQFDYVRFPAAGKNEVDYGENPIPKADAISGFLKEAASEINKMGVPVSADIFAIV CETPGDTEGIGQVLERIGMDIDYISPMIYPSHFANASRGMMGNGKGQSINGILFTAPD LKPYEVVYNVLLKTKDRISKVEGYRAKVRPYLQGFTASYLPKGYYQHYGPEQIRQQIK AVYDAGYEEWIFWNAANTYTESAFARE" sig_peptide 17387..17458 /locus_tag="ClothDRAFT_1967" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.699 at residue 24" misc_feature 17600..18619 /locus_tag="ClothDRAFT_1967" /note="Uncharacterized conserved protein [Function unknown]; Region: COG1306" /db_xref="CDD:31497" gene 18885..20105 /locus_tag="ClothDRAFT_1968" CDS 18885..20105 /locus_tag="ClothDRAFT_1968" /inference="protein motif:COG:COG1306" /note="KEGG: afr:AFE_2171 GTP-binding protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430107.1" /db_xref="GI:256005138" /translation="MFFSNFSGIGFSFSLAACKDTGVQVNNPAPTAQATDNGEANNGG NTDGEAPETSEPSEESPVPNNSGEDAKPVKKDIKVKALYLTGWTVGSDERLQHYVDLA NRTEINAYVVDIKDDDGYVGYESNIPAVREIGAWKSKYNVDKVLKTFHDNNIHVIGRL VCFKDPVLSSKKPELAVKSVNGGSWRDNHNLTWLDPYNKDSWPYLIEIAKEAVEKGFD EIQFDYIRFPNDGSKKSMSFNTGGKEKHEIINEFLAYAREQLPGVVLSADVFGIILES PADTEDIGQYLEKIVKDVDYISPMVYPSHYAVGQIVNGVQFMKPDLDPYGVVYQSLVK CNNRLAQVEGYKADVRPYIQDFTASWLGKGYYQSYGPEQLRQQIQAVYDAGYEEWICW DANNTYSEEAFLKE" misc_feature 19104..20078 /locus_tag="ClothDRAFT_1968" /note="Uncharacterized conserved protein [Function unknown]; Region: COG1306" /db_xref="CDD:31497" gene 20383..22767 /locus_tag="ClothDRAFT_1969" CDS 20383..22767 /locus_tag="ClothDRAFT_1969" /EC_number="1.17.4.1" /inference="protein motif:TFAM:TIGR02504" /note="KEGG: sfu:Sfum_0259 ribonucleotide-diphosphate reductase subunit alpha; TIGRFAM: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; PFAM: ribonucleotide reductase large subunit; Ribonucleotide reductase large subunit domain protein" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent" /protein_id="ZP_05430108.1" /db_xref="GI:256005139" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR013344" /db_xref="InterPro:IPR013509" /translation="MNLTENAIKVLKKRYLAKDENGNLLEDPEGMFRRVARTVASADK EYVSEEELKSIEQEFYDMMVNLDFLPNSPTLMNAGRPLGQLSACFVLPIEDTMEGIFE TIKNAALIHKSGGGTGFSFSRLRPKGASVNSTGGVASGPVSFMKVFNAATEAVKQGGT RRGANMGILRVDHPDIVEFITCKKNNADITNFNISVGITEEFMNAVENNEYYNLVEPH TGKIVGKQNAREIFDLIVDMAWNNGEPGIIFLDRLNKDNVTPELGEIESTNPCGEQPL LPYEACNLGSINLSNMLKYVDGKPEVDFAKLRTTVWKAVHFLDNVIDVNKYPLPEIDK MTRGTRKIGLGVMGWADMLCKLNIPYNSQSSIDLAEKIMHFIQDESRKASMELAEKKG VFPYYDKSIYKNLGIRVRNATTTTIAPTGTLSIIAGVSSGIEPLFAISYIRNVMDNDE LVEVNPVFKQVAKEEGFYSDELMRRIAKKGSIRGFDEIPEWIQDVFVTAHDISPDWHV RMQAAFQKYTDNAVSKTVNLRNEATRKDVADAFWLAYKTNCKGITIYRDGSRDLQVLN IGKVKGKEESVSKAREEGPAKPKEQIKPVSGIAPRPRSEIATGFTEKVKIGCGNLYIT VNYDDYGICEVFTNTGRAGGCPSQSEATARLVSIALRSGVDYKYIVEQLKGIRCPSTI RQKGLKVLSCPDAIGRLIEKVAKLQNGQKIMATEAHITDEQRFQRPTANTYYKFEDAS EEEEVDFRIAELENDTEENDTENADTAVCPECGRKVEHEGGCVVCRNCGYSKCG" misc_feature 20383..22764 /locus_tag="ClothDRAFT_1969" /note="ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665" /db_xref="CDD:181531" misc_feature 20383..20631 /locus_tag="ClothDRAFT_1969" /note="Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317" /db_xref="CDD:144053" misc_feature 20548..21696 /locus_tag="ClothDRAFT_1969" /note="Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888" /db_xref="CDD:153089" misc_feature order(20593..20598,20641..20643,20722..20730,20863..20868, 20872..20874,21187..21195,21199..21201,21232..21234, 21634..21651) /locus_tag="ClothDRAFT_1969" /note="active site" /db_xref="CDD:153089" misc_feature order(20626..20628,20671..20676,20683..20688,20692..20697, 20704..20709,20716..20718,20770..20772,20779..20790, 20797..20799,20812..20814,20821..20823,20830..20835, 20842..20844,20848..20856,20860..20862) /locus_tag="ClothDRAFT_1969" /note="dimer interface; other site" /db_xref="CDD:153089" misc_feature order(20665..20667,20671..20673,20680..20682,20716..20718, 20755..20757,20773..20775,20779..20781,20794..20799, 20812..20814,20842..20850) /locus_tag="ClothDRAFT_1969" /note="effector binding site; other site" /db_xref="CDD:153089" misc_feature <21883..22056 /locus_tag="ClothDRAFT_1969" /note="Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939" /db_xref="CDD:186877" gene 23022..25211 /locus_tag="ClothDRAFT_1970" CDS 23022..25211 /locus_tag="ClothDRAFT_1970" /inference="protein motif:PFAM:PF02638" /note="PFAM: protein of unknown function DUF187; S-layer domain protein; KEGG: oan:Oant_1822 protein of unknown function DUF187" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF187" /protein_id="ZP_05430109.1" /db_xref="GI:256005140" /db_xref="InterPro:IPR001119" /db_xref="InterPro:IPR003790" /translation="MERRCKRLVCILLSFLVIAGVFTFSGAKTEPWSAYQKFIPNETP VVKRHLRGVWISTVANLDWPSVETRKIENPSERIRKTKEELVEIFDKAVEMNLNAVFL QVSPEGDAFYKSDIVPWSRYLTGTFGEDPGFDPLEFAIEEAHKRNLELHAWFNPYRVS TNTSAATISSLKVEKSVYKEHPDWIRTAMNRFVVDPGIPEARQWVIDRVMEVVKKYDV DGVHFDDYFYYEQYVGELKDQDTYNKYNKGQFSNIGDFRRNNTYLLVKELSQKIRATK PWVKFGISPSGVWGNKSDGHSYGSNTSASLTNYDKSFADTKKWVQEELIDYIAPQVYF TFANSRAPYGEIALWWSDVCRGKNVHLYIGQAFYKINDDSDQYFKGENAVPELTRQLK FNAVKPEIMGTVLFRFANFKDSGKQQAVNAVKNDLWSQKALIPPMPWKGGNAPDAPIL GRLESLPDGVEISWMDNDPDTAYFAIYRFNAGEKMDITSDSSAYKLIATVRKNSNGVQ KFVDYGVLDADSVYYVVTALDRLHNESEGLAISTNQSEYFPDVGMKYSWAVDAIDMLY EKGVVKGDESGMFNPGVNTKRADFTIMIVKALALKADFEDNFADVRKDAYYYEAVGVA RALGIVKGDGKNFNPDANITREDMMVIVVNALKAAGAKIDEADEQFLENYGDANSISG YARKSVAVLTKAGVVNGYDGKIHPKSLATRAEIAVVVSKLLTNIEYL" sig_peptide 23022..23105 /locus_tag="ClothDRAFT_1970" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.801 at residue 28" misc_feature 23169..24242 /locus_tag="ClothDRAFT_1970" /note="Uncharacterized BCR, COG1649; Region: DUF187; pfam02638" /db_xref="CDD:111529" misc_feature 24663..24791 /locus_tag="ClothDRAFT_1970" /note="S-layer homology domain; Region: SLH; pfam00395" /db_xref="CDD:144111" misc_feature 24840..24968 /locus_tag="ClothDRAFT_1970" /note="S-layer homology domain; Region: SLH; pfam00395" /db_xref="CDD:144111" gene 25453..25989 /locus_tag="ClothDRAFT_1971" CDS 25453..25989 /locus_tag="ClothDRAFT_1971" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430110.1" /db_xref="GI:256005141" /translation="MKFHKIVIVTAITAVLSSVSVFATPKATETPKTDTTQQKNHCEQ KRGSEINKDRAKEKGSDTQIDPIERLKKKKAKVKELYDAGKITKEEADDLNAKIDAKI KEIEEFNKLTVEQKREKLKKAFKEKIDKKVKEGKISRDKADEIIRKFNKKIDEWDGTG YPPFIHKSCIKKHRCKQR" sig_peptide 25453..25524 /locus_tag="ClothDRAFT_1971" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 at residue 24" gene 26480..40360 /locus_tag="ClothDRAFT_1972" CDS 26480..40360 /locus_tag="ClothDRAFT_1972" /inference="protein motif:PFAM:PF00395" /note="PFAM: S-layer domain protein; Ig domain protein group 2 domain protein; SMART: Ig domain protein group 2 domain protein; KEGG: pfl:PFL_0133 calcium-binding outer membrane-like protein" /codon_start=1 /transl_table=11 /product="S-layer domain protein" /protein_id="ZP_05430111.1" /db_xref="GI:256005142" /db_xref="InterPro:IPR001119" /db_xref="InterPro:IPR003343" /translation="MRKNFKVLISILLCFMMLFGEIVPAGLPSAKALAETDNVLEVQD SSFNQENNNFSPEKTVSEDVYEEEELLQNPDEEIPGLKAASSTMSVSSVFSISGKVVL PEGKVAPSGGLTVRVYAKSSSKTNNITVIIPEGKSSADYTVIVPEATTYTLYYQTSNS DYVDTGYYSVIGTVRSSSAADQIRLTADVPSETDIDLTLIAKRIISGTVTLPDGEIAP AGGVSVTVTAVSGSDKATANVVIPEGLGSANYTLKVPPSTSGKGYLVSYQTSNKIYLQ TAYYSMRGSVRYDTLATLVDVIDEDRKDINLNLIAKKKITGTVSLPEGTAPKDGVTVT VWATYGSDKDSQTVTIPEGASSVEYVLYVPDGSGYTLYYETTNVAYLSKGYYNENGTV KDSKAATPVDTVSKDAADKNITLIAKRIVSGKVSLPKGVAPEGGIKVEVIVALNNTKI ESTTITIPEGESEATYSMYVPTGSGYNVSYKTSNSLYVEQGYYKKGSTVRYLSSATLI TVENEDLNDIDLELIEKRTISGILSMPSGTAPKGGISFEITAYNSSTEAKVTVTIPEG ESSVPYSINVPADEGYIIKCKLLTLQAIYMNEQYYSSGGTVYNVASASKISTLSGNQP NINIMLLEKRTVSGTLSFPEGYYAPPGGIIFTHETDGRITFIYIPEGERSAPFTIYYN PGVYKLYYECDEDDIFVSPGYYSKGGTVVDKNSADDIDVREGNQVGINLVLLLKKTIS GKVVLSNGVAPEGGYTVKVKASGSKGSAEQTVVIPKGEKSADYILFVNPGDKYRVWYE TSKEYNFVSPMYYNSDGMVRDSSSASLLDLTKENKTDIDLTLTEMRSVSGNIVLPSGV APSGGISADIVVSNGKDSGKVTVKIPAGERFASYTAYVPAGKDYKVKYTVDAKSDYAT DGYYGVSGTTLNASSAASLDLTSENKTEINMTLIPKRTISGTVSLPSGMTLGSDTKVT VYAGDSYSTTVTIPKNGSSVEYAIKVPPNSAGSGYKVYYKLSSTTMLISPGYYSSSGM TASEIGAELVDVSSTDATVDLVLIPKSSINGSVILPEGVAPKGGLKVTVTASNNKNKG SVTVTIPEGKSSAEYSVYVPSGTGYLVEYSVTDEEYVKKGYYSTSGTVRDSSAATLIS LDGESKQNVNLTLLRNNKITGNVTLPKGVAPSGGLKVTVCASNSTGSVKTTVTIPQGY NTISYTLFVPQGKNYTVWYEASDRRFMPTGYYSDGGTTVDKSKAKLIDATINVSSINI DLIPKMEVSGSVKLLSAPAPAGGISVKLTIDNKISSDSVDVVIPEGFMSAPYALYVPA GENYILKYTTSSSGFVSPGFYSESGSKETEKEASYLNITGDRTGIDIPLITKRTIRGT ILLPEGYAPAGGVSVKVTAQSSSDKITASFVIPEGENAVPYTLYVSSGKEYIVKYETT DEKYVSTGFYSMLKTTRLESEADKLDTTEADQVGINLKLISNKYISGTVSIPSGIAPF GGIKVTLKATNGKDTKTVNVVIPEVSSSTTYKIYVPEGKDYELSYSISNGDGKYFPTG YYNGLTATREKGECVLLDLSGESKEGINITLIPNRLVTGSLILPSGVAPAGGLKITVR ASNKRDSVPTTVNMPQGSSSVVYRMYLPEGSDYTIGYTISHEDYLNGYYNINETVLTQ SEATTFNVEKSDILGLNIVLIAKRTITGIVSLPDGKTAPAGGIDVTISAGSYSTKVTI PQSKNSVSYTLKVSPNAVGSGYAIKYAITSATDFVQTGFYGEDKTVARVQEADLVDVS LENKAGINLTILEKRVIAGVFKLDYGYAPSGGMNVTISATGKNAEGKSMTYQQVIYLP FGHSQAEFKLNVDPSYYATGYKLKYTMDSEYGYAEIGYYNDIEGTVQNEKEATLIYVD YKDQLGKEITAISKNHISGSVSLPDGAIAPKGGIKVSVHAEGPGGSGSANVTIPEGQS GAGYVLIVPPGTQYKLYYSMAPNNMYVSSGYLSSEGTVLDSKKAELFDVKGDVDNKNI VLIPKRKVSGEVTLPVGVFAPKGGLKVEVTVQSSQSSDSLTVTIPENGQSQSFELYLP PQNGYKLFYSLASGTTYVSKGYYAQSGTVIDDKLASEIDLRDKDLTGVKLSLVENNII KGSVILPYGVAPEGGIEVRITADNGKFKNTTNVTIPENGNKIDYVLPVPPASGYRVSY QVSTGLDFIPTGYYGSEGTVTSSSGALKLDLTSGGKEGIDLSLVYYNSISGTVSLPEG VAPKEGVTLTVFAANSRNKRETTVTIPSGKSSANYNIYIPDGYGYKVYYVMTPDVKYV DKGFYAGIDTVTDEKEAATVDVSGGSVTDINLTVIAKRTISGTISLKDGEKAPQEGIA VRITAIDGDEQTVVIPYGKSSVAYSLNVVPNAAGKGYKVRFETIKNYGYVRYGYYTKD GAVRSEANAEFVDVSRGDKDNVNFELVRPRTIKGTVGLPEGAAASRDITVTVIASNSI DSADTVVYIPKGSKEAAYTLLVPPNDSNDEYKVRYENWHDNSFADIGYYGSSETVRSA DLAKGVNVRKENAEGINLTLIAKKTVSGKISLPYGTAPRGGLTVTVYAENNTDKVISY VTIPEGKNSMDYSLSVPVGKGYRIGYEMSIKNDFVPWGYYGNKGMVFMPGEAYLMNIS SDIGGIDLELIEKKSISGKVILPEGTAPKGGIKIEVYAEDAGDTWVTIPEGQSYAEYT MKVLPSLQGSGYKVKYVVSSDYGLVGYGYYNKNGTVRNSKLAEPVDANYKDVANIDIE LMKPRVISGKVSLPDGVAPSGGISLNIAIFNETDGNSQIITIPAGKSSATYSISVPPN DPGYEYTVRYENWSNKIYTTYGYYNSKGTTNNMSYAQLVDVNEKDASNIDMVLLKKAT VSGVIEVPENAVLPEEGLHVRIYVSNDVETYSANVTIPYGTSSVPYSVHVEEGTGYRL FYVLDSNESFMEYGYYADSGVYTDKKMAKVFNVYNQNISGYKLKLLEKRRISGKLIVP DGAFENEGYFEVAISATNGFDTGTAKVLVPYGKAEANYTLTLPAGSGYILQYEISKIK GYTSVGYYGAEGTVRNRNEALALDLRETDLTDIDISLIQDMTISGTIRIPQGTAPAGG IEVVVTATDESGNMASEKVTIPEGESSADYYLNVPPNAPDSGYRVRYSVAADKYAAIG YYSESGTKALPNEATPVDVSSKNAEEINLVLIEKKIVRGVVSIPEGAAGKGGLPVTIK ATSRLFSVEDAVTVTIPEGESMAPYTLWVSPNVEGADYIISYEVSNTAYINSGYYNQA GTVVDINMATPVDVSNGDYTNANISLIRSRKITGKLILPEGETAPKGGLPVTVFAEKT GYTGYRVTKTVTIPEKQSSVDYILYVPESTSKAVKLKLQASTGNGTEDKADDYVLNTE VFVPVIDGSGSSEYKVGYSYTQDEQYFRSGFYTKDGTVPAISMAGTVNVAKKDVQNVD LTLLKKNRTIKGVVKLPDGKTASGNIEVEITAENDALDFAPQKTVTIGKGKSSVEFEI AVPSLDSYRIKYTIKSTTDGYVTSGYYATTGTVGKPELSTLVSTSSGNVDGINLNLIP GMEIRGGVSLPTGQQVNRNDFWLWVSASNENYESSVYVTIAKGSSSANYSLYVPEGSG YIVSYSILPLFGEYVQKGYNNASVTTANKDSATKYNVTKNLSGINLTLLPLDRAISGT VSLPDGTASVGYTIHVPANKRGSGYQLEYSVVSGNEGGAYKEKGYFSLAGTSADKAKT SIIDVSSKNSTGNDMTLLADTMVPVDAIMLDKYQVTIQSGKTVNLKVKYLPENATNKT IKWTSGNTNVAEVSSEGVVKAKATGTSVITARTHNAVITVFTVRVVPAESSALSIDKL SVSINPGEKEQLEAIFTPQSEDDKVIWKSDNTDVATVSENGLVTAKKSGTAVITAMSS KDPSVYATCEVVVITPVTGVEIDKTRLEIKVGYNEKLTAGVLPETASYKGITWISSDE SIVRVSQSGEVTAVSIGTAVVTASSIYNPSLKAVCTVKVIPVPVEEIKLDKQTVTLYP DEYILINAEVLPSNASDKRVAWKSENTNIATVTAEGLVKAVNIGETKIIATSLYDSSK TAVCVVKVVARPVTKVTFKNVPESILVGQSKALEVTVSPSNATDKTLVWTSSDEKTAT VTQDGVVTGKGVGTVTITAAWKNDPSVEAVCTLKVEPVKVTAIKLKQTSISLGIGDEV KLVAEIIPENATNKEIIWSTSDRDIVTVSSDGVVKAVSMGRATITATSKESSSIKATC SVTVTGIEVSQVRINNKPSTLAVGSTHKLTVTINPTNASDKTLEWSSSDTSIATVSSS GVVTAKKVGTVTITVSSKSKPSCKDSCTIKIVEATPSPTPAEIVNEPVVIPGGPGGGG GGVPVASIGGSPTPSATPTVTPTATPTSTPSAGKTPAASPTPAPVVTDTNSLDFFTDI KGHWAAEFFADLLRREIVNGYPDRTLRPNAPITRAEATVMVVKAAGFEVSDSIPLTCT DKDSVPAWAKPYVATAMHKGVVKGYEDGSFRPSNRLTRQETVVLVLRAFGIEEAQDKT LAFADSDKIPAWSRGYIKKAVELGIIKGYSDNTFGPQREITRAEVVTIISKCIQLKGR " sig_peptide 26480..26584 /locus_tag="ClothDRAFT_1972" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.701 at residue 35" misc_feature 37817..38050 /locus_tag="ClothDRAFT_1972" /note="Bacterial Ig-like domain (group 2); Region: Big_2; cl02708" /db_xref="CDD:155068" misc_feature 38081..38293 /locus_tag="ClothDRAFT_1972" /note="Bacterial Ig-like domain (group 2); Region: Big_2; cl02708" /db_xref="CDD:155068" misc_feature 38315..38554 /locus_tag="ClothDRAFT_1972" /note="Bacterial Ig-like domain (group 2); Region: Big_2; cl02708" /db_xref="CDD:155068" misc_feature 38570..38773 /locus_tag="ClothDRAFT_1972" /note="Bacterial Ig-like domain (group 2); Region: Big_2; cl02708" /db_xref="CDD:155068" misc_feature <38870..39280 /locus_tag="ClothDRAFT_1972" /note="Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492" /db_xref="CDD:35051" misc_feature 39080..39310 /locus_tag="ClothDRAFT_1972" /note="Bacterial Ig-like domain (group 2); Region: Big_2; cl02708" /db_xref="CDD:155068" misc_feature 39824..39946 /locus_tag="ClothDRAFT_1972" /note="S-layer homology domain; Region: SLH; pfam00395" /db_xref="CDD:144111" misc_feature 40007..40129 /locus_tag="ClothDRAFT_1972" /note="S-layer homology domain; Region: SLH; pfam00395" /db_xref="CDD:144111" misc_feature 40187..40321 /locus_tag="ClothDRAFT_1972" /note="S-layer homology domain; Region: SLH; pfam00395" /db_xref="CDD:144111" gene complement(40436..41068) /locus_tag="ClothDRAFT_1973" CDS complement(40436..41068) /locus_tag="ClothDRAFT_1973" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: sfu:Sfum_1249 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430112.1" /db_xref="GI:256005143" /translation="MNNIQNPVYIFTRRIVSPFQDLIIDYPFATGFKTLNIQNIINSR IIKTVNELIYEQTGKLLEQGYKSPQMTVQGWYEIKTNEKGVLSLSIGNYTIAYPAAHG LTIIKSLTFDISTGKEYRLEELFKPGSDYVGTLSKIIERQIKEREIPILGEFKGIRPN QDYYIADKALVIYFQLYEITPYAFGFPMFPISVYEIQDIIREGSPLAAML" misc_feature complement(40466..40822) /locus_tag="ClothDRAFT_1973" /note="Protein of unknown function (DUF3298); Region: DUF3298; pfam11738" /db_xref="CDD:152174" gene 41286..42047 /locus_tag="ClothDRAFT_1974" CDS 41286..42047 /locus_tag="ClothDRAFT_1974" /inference="protein motif:TFAM:TIGR02895" /note="TIGRFAM: RNA polymerase sigma-I factor" /codon_start=1 /transl_table=11 /product="RNA polymerase, sigma 28 subunit, SigI" /protein_id="ZP_05430113.1" /db_xref="GI:256005144" /db_xref="InterPro:IPR014244" /translation="MEVRKINTHNREKKLDDIVYDDFISTLRQIKEGNHQLREEFISE YKPFILKVTSNATGKYIDTRNSDEFSIALSAFNEAIDKFDIEKGYNFFLFSEQVIRRR LIDYSRSNKDDKEYPFSFFDDEYFYNNEKLLSKSYIGFEDIEAREDIEELKKKLQEFG ITFLDLVLNVPKHRDSRQLCIRLAKMLAEDEQMYNALMKNKNIPRNELKKKAKVHGRT IGNNRKYIIALCLIFRSNLNLSKRYLEYYTMDGGK" misc_feature 41316..42041 /locus_tag="ClothDRAFT_1974" /note="putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311" /db_xref="CDD:181376" misc_feature 41406..41618 /locus_tag="ClothDRAFT_1974" /note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542" /db_xref="CDD:146937" gene 42054..43514 /locus_tag="ClothDRAFT_1975" CDS 42054..43514 /locus_tag="ClothDRAFT_1975" /inference="protein motif:PFAM:PF00942" /note="PFAM: type 3a cellulose-binding domain protein; KEGG: eca:ECA1981 endoglucanase V" /codon_start=1 /transl_table=11 /product="type 3a cellulose-binding domain protein" /protein_id="ZP_05430114.1" /db_xref="GI:256005145" /db_xref="InterPro:IPR001956" /translation="MNRLGIIYEIQGMKAVVLTSEGEFLIIRRRKDMKVGQQVSFENE DIYNVRGKRFLYVAAAVSSVAAVLVVMFLYFQSAFLSNTDNIYGYICVDINPSVELVI DETCRVLEVRPQNKDGEQLISGLELLDKNVEDVVYELINRSISFGFVKADDNRKIVLI SGALNDKRNELKTKKENDEAELTELLDNIKARVDRIDNIKVRTITATSRERKDALKYG LSMGKYCLYLEAQELNGSITIDEVHDMSISDMIEKLEQMKLALKDEASPKLQTTPTLG GETAQISPESMQHSTVPGLPETPSSSEKTIAPTLHGTPGVPDEKTLQPSTPTESSEYV QDGTKGLKIQYYSRKPHDSAGIDFSFRMFNTGNEAIDLKDVKVRYYFKEDVSIDEMNW AVYFYSLGSEKDVQCRFYELPGKKEANKYLEITFKSGTLSPNDVMYITGEFYKNDWTK FEQRDDYSYNPADSYSDWKRMTAYISNKLVWGIEPN" misc_feature <43131..43328 /locus_tag="ClothDRAFT_1975" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" gene 43633..44136 /locus_tag="ClothDRAFT_1976" CDS 43633..44136 /locus_tag="ClothDRAFT_1976" /inference="protein motif:PFAM:PF02810" /note="PFAM: SEC-C motif domain protein; KEGG: gsu:GSU1048 SecC motif-containing protein" /codon_start=1 /transl_table=11 /product="SEC-C motif domain protein" /protein_id="ZP_05430115.1" /db_xref="GI:256005146" /db_xref="InterPro:IPR004027" /translation="MVHMSLYNEWQKLCEKQRTEEENNEFWNTYLEKEMKVYEFILEH HDEVVEGKLAELAEKFDMEPVVFAGFMDGINTSLKNPVKLEELGDDSNIRLEVDFEKL YYNMLDAKAYWLYNLPQWDNILSQERRNEILKDYNRAHIAVSRKIGRNDPCICGSGKK YKKCCGA" misc_feature 43642..44088 /locus_tag="ClothDRAFT_1976" /note="hypothetical protein; Provisional; Region: PRK05590" /db_xref="CDD:180153" gene complement(44281..44829) /locus_tag="ClothDRAFT_1977" CDS complement(44281..44829) /locus_tag="ClothDRAFT_1977" /inference="protein motif:PFAM:PF02632" /note="PFAM: BioY protein; KEGG: bpt:Bpet1713 BioY" /codon_start=1 /transl_table=11 /product="BioY protein" /protein_id="ZP_05430116.1" /db_xref="GI:256005147" /db_xref="InterPro:IPR003784" /translation="MRNKYLKDMMYAAVFTGLMTVLGWISITLPVLPAPITGQTLGVM LAGVILTPKQAGLSMTTYIALGAAGLPVFQKGGAGIAYLTGPTGGFIIGFLIGAIVIS LIKGDGKGTLKVGTACIVGGMLAVYAIGIPWLCFEITGSLFSWPHVVSTLAFVPGDII KVFIATMIGVRVNKSLEYQLSA" misc_feature complement(44302..44745) /locus_tag="ClothDRAFT_1977" /note="BioY family; Region: BioY; cl00560" /db_xref="CDD:153855" gene complement(45039..46928) /locus_tag="ClothDRAFT_1978" CDS complement(45039..46928) /locus_tag="ClothDRAFT_1978" /inference="protein motif:PFAM:PF00884" /note="PFAM: sulfatase; KEGG: afw:Anae109_1028 sulfatase" /codon_start=1 /transl_table=11 /product="sulfatase" /protein_id="ZP_05430117.1" /db_xref="GI:256005148" /db_xref="InterPro:IPR000917" /translation="MERLKNFINQRFNVAETIYWIMFIIFLMLKCIYFQFTTKLNTVP YLSSVNITMFLSSFAVLLIISAFIALVFNKFRFIALFTINFLLTILLIADTNFFRYYY NLITIPVFFQLNIKLVSSVNESILSQFMLKDLIYLVDLPFMLIGVLLLNKNTRKLHIS RRVYRFAAFLVVGMVTFLSVFHTSNLNSFAYSNNYSAKSLGVLFSHYYNTKLLIEENL LEDDSFTQEDKNSIMALYETKKNEKDSLDSRLKGIAKDKNLIVVQMEALQQFVINLKI NGKEVTPNLNRLICESLYFDNVFYQVSGGNTSDAEFVTNNSLYPAKEGAVYHLYPENT YHSLAKILKEKGYNTYSLHGFDKTFWNRDEMHMSLGFDRFFNEEDFVLDDFAGWDGQA LSDSSFFRQSFDKIDTTKPFYSFYITLSSHHPFTYFEDYDFDVGEFEGTYIGNYLKAA NYLDKCIGEFIAELKKRGLYDNSLLVFYGDHAAVKKIEADGLMKLLDMEYSEPEWMKL QKVPLIIHYPDQSKPEVISTIGGQIDILPTIANLMDFDAPYALGKDLLNYDENKGYVV LRDGSVVTKDFIYFNDLREVYDYDTGKLLDLNLYDDKITSYINELNVSDIIITKDAFK YGFEN" misc_feature complement(45042..46868) /locus_tag="ClothDRAFT_1978" /note="Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368" /db_xref="CDD:31559" misc_feature complement(45234..46160) /locus_tag="ClothDRAFT_1978" /note="Sulfatase; Region: Sulfatase; cl10460" /db_xref="CDD:186998" gene 47195..47530 /locus_tag="ClothDRAFT_1979" CDS 47195..47530 /locus_tag="ClothDRAFT_1979" /inference="protein motif:PFAM:PF00301" /note="PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: dal:Dalk_5026 rubredoxin-type Fe(Cys)4 protein" /codon_start=1 /transl_table=11 /product="Rubredoxin-type Fe(Cys)4 protein" /protein_id="ZP_05430118.1" /db_xref="GI:256005149" /db_xref="InterPro:IPR004039" /translation="MKKLWKCSVCGYIHEGEDAPEKCPKCDASKDKFVQLSDEDANKV YMSDRTNDIHMEIVNLAARIIALCEEGININLDPPCVEAFKRARNEAWVIKQRSKAEM EGHMKKGKW" misc_feature 47201..47302 /locus_tag="ClothDRAFT_1979" /note="Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-...; Region: rubredoxin_SM; cd00729" /db_xref="CDD:29432" misc_feature order(47213..47215,47222..47224,47261..47263,47270..47272) /locus_tag="ClothDRAFT_1979" /note="iron binding site; other site" /db_xref="CDD:29432" gene complement(47551..48507) /locus_tag="ClothDRAFT_1980" CDS complement(47551..48507) /locus_tag="ClothDRAFT_1980" /inference="protein motif:TFAM:TIGR00704" /note="TIGRFAM: Na/Pi-cotransporter II-related protein; PFAM: Na+/Picotransporter; KEGG: pca:Pcar_1565 Na+/phosphate symporter" /codon_start=1 /transl_table=11 /product="Na/Pi-cotransporter II-related protein" /protein_id="ZP_05430119.1" /db_xref="GI:256005150" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /translation="MNFRLVIVIVNIIIGTICIVYGVKLMSSSLEKANIRRMKKYLSL FTEKVPLATLTGTVLTALVQSSTAITVITVGLVNSGMLKLTQAVGIIYGANIGTTITA QLMSFRLTNFSYIIIGLGLLIAFFSKRRTPANMGWALTGLGIMFAGLNILNLGVPYIK ENDNIYELFRVYGQNPLIGLLTGMVTTMLVQSSSATVGLTIVLFNTGLISFESALGLT LGDNIGTCITAQLSSIGTSISAKRTAWAHTLYNVIGTIIAFIFLKPFAFMIQAITYGI GQDETRLIANAHTIFNILSALVFLPITGYYVKFLEWLIREKE" misc_feature complement(47557..48438) /locus_tag="ClothDRAFT_1980" /note="Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704" /db_xref="CDD:162003" misc_feature complement(48052..48438) /locus_tag="ClothDRAFT_1980" /note="Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690" /db_xref="CDD:145706" misc_feature complement(47692..48009) /locus_tag="ClothDRAFT_1980" /note="Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690" /db_xref="CDD:145706" gene 48703..49041 /locus_tag="ClothDRAFT_1981" CDS 48703..49041 /locus_tag="ClothDRAFT_1981" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430120.1" /db_xref="GI:256005151" /translation="MSVFPSNIIYNFLIAFGVIVGASLFAGLGALINDHPPLKTMFQI ASSIKIWAVAVALGGTFSTFEILEKGIFKGEIRSIIKQAVYVVVAVIGANVGYGFIRL IQKCGESMFK" sig_peptide 48703..48783 /locus_tag="ClothDRAFT_1981" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.756) with cleavage site probability 0.645 at residue 27" gene 49038..49514 /locus_tag="ClothDRAFT_1982" CDS 49038..49514 /locus_tag="ClothDRAFT_1982" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430121.1" /db_xref="GI:256005152" /translation="MRKIAYKFFVCFVTGLIGGILLGCTLMSTLVSYRIDKYHEEIML LKTRIEESDAKYNKLKESFDSMNKKKFLVSDIQVFLIFKGNEEDDFDKMQLEKYIKDR YQDLLWKEVKSIDMDLVVKLVDEDIYRIENKNYRLGVNRVLISDVFKIWVTVKKID" sig_peptide 49038..49109 /locus_tag="ClothDRAFT_1982" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.707) with cleavage site probability 0.424 at residue 24" gene 49572..50297 /locus_tag="ClothDRAFT_1983" CDS 49572..50297 /locus_tag="ClothDRAFT_1983" /inference="protein motif:PFAM:PF02146" /note="PFAM: Silent information regulator protein Sir2; KEGG: sat:SYN_01020 Sir2 family NAD-dependent deacetylase" /codon_start=1 /transl_table=11 /product="Silent information regulator protein Sir2" /protein_id="ZP_05430122.1" /db_xref="GI:256005153" /db_xref="InterPro:IPR003000" /translation="MEIDTFREMVEKSGSIVFFGGAGVSTESGIPDFRSSTGIYGQKT RYSYPPEVMLSHSFFMEHTEEFFEFYKEKMIYKDAKPNAAHIALAKLEKHGKLKAVIT QNIDGLHQAAGSENVIELHGSIHRNRCMKCNESYDLEYVLNSPGTVPLCKKCNGIVKP CVVLYEEPLDTDSIDRAVDYIEKADMLIVGGTSLAVYPAAGLIQYYRGDRLVLINKSP TPYDRRANLIIRDSIGAVLGSVV" misc_feature 49587..50252 /locus_tag="ClothDRAFT_1983" /note="NAD-dependent deacetylase; Provisional; Region: PRK14138" /db_xref="CDD:172627" misc_feature 49593..50264 /locus_tag="ClothDRAFT_1983" /note="SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195" /db_xref="CDD:185818" gene complement(50369..50980) /locus_tag="ClothDRAFT_1984" CDS complement(50369..50980) /locus_tag="ClothDRAFT_1984" /inference="protein motif:PFAM:PF00160" /note="PFAM: peptidyl-prolyl cis-trans isomerase cyclophilin type; KEGG: pla:Plav_3052 peptidyl-prolyl cis-trans isomerase cyclophilin type" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl cis-trans isomerase cyclophilin type" /protein_id="ZP_05430123.1" /db_xref="GI:256005154" /db_xref="InterPro:IPR002130" /translation="MIGRTNTKFLAIILICLITAVFTVGCNKSKYSVKHPKVQIEMED GGKMILELYPEYAPETVDNFITLAEEGFYDGLTFHRIIKGFMIQGGDPNGDGTGGSGK TIKGEFANNGFTKNKLSHTRGVISMARKSNDPNSATSQFFIMHGDAPYLDGDYAAFGK LIEGYDVLDKIANTPVDPNPSNPTELSVPKEEVRIKTVTVLEK" sig_peptide complement(50903..50980) /locus_tag="ClothDRAFT_1984" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.555 at residue 26" misc_feature complement(50390..50851) /locus_tag="ClothDRAFT_1984" /note="cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317" /db_xref="CDD:29390" misc_feature complement(order(50516..50518,50528..50533,50555..50557, 50561..50563,50594..50599,50717..50719,50723..50728, 50735..50737,50741..50743)) /locus_tag="ClothDRAFT_1984" /note="active site" /db_xref="CDD:29390" gene 51344..52192 /locus_tag="ClothDRAFT_1985" CDS 51344..52192 /locus_tag="ClothDRAFT_1985" /EC_number="6.3.1.1" /inference="protein motif:TFAM:TIGR00669" /note="KEGG: aspartate--ammonia ligase ; K01914 aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: aspartate--ammonia ligase" /codon_start=1 /transl_table=11 /product="aspartate/ammonia ligase" /protein_id="ZP_05430124.1" /db_xref="GI:256005155" /db_xref="InterPro:IPR004618" /db_xref="InterPro:IPR006195" /translation="MNDNLNGVERPVSFDVKAIGGNTVEIVHSLAKWKRMALAKYGFK VGEGLYTDMNAIRRDEDLDNLHSIYVDQWDWELVINKEDRNEETLKNIVKKIYNVLKK TEDFIAEQYPQIPKFLPEDIFFITTQELEDMYPELSPKEREDAIAKEKKAIFLMKIGG VLKSGKKHDGRAPDYDDWTLNGDIILWYPLLERSFEISSMGIRVDENSLLSQLKEAGC EERKEMKFHKDLLQGKLPYTIGGGIGQSRICMYFLKKAHIGEVQSSVWPDSMIEICEN ANINLL" misc_feature 51344..52165 /locus_tag="ClothDRAFT_1985" /note="Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268" /db_xref="CDD:185874" misc_feature order(51428..51430,51434..51436,51512..51514,51551..51553, 51557..51559,51563..51571,51929..51934,51944..51946, 52061..52066,52070..52075,52082..52084) /locus_tag="ClothDRAFT_1985" /note="active site" /db_xref="CDD:29813" misc_feature order(51449..51454,51509..51511,51515..51517,51632..51634) /locus_tag="ClothDRAFT_1985" /note="dimer interface; other site" /db_xref="CDD:29813" misc_feature 51509..51517 /locus_tag="ClothDRAFT_1985" /note="motif 2; other site" /db_xref="CDD:29813" misc_feature order(52073..52075,52082..52084) /locus_tag="ClothDRAFT_1985" /note="motif 3; other site" /db_xref="CDD:29813" gene 52329..53723 /locus_tag="ClothDRAFT_1986" CDS 52329..53723 /locus_tag="ClothDRAFT_1986" /inference="protein motif:TFAM:TIGR00457" /note="TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: bba:Bd1054 asparaginyl-tRNA synthetase" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="ZP_05430125.1" /db_xref="GI:256005156" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /translation="MKTTLVKSLYRNTKDYVGKEIVVAGWVRTVRDSKAFGFIELNDG SFFKNLQIVFEEKNLPNFKEIAKLSVGSAIIAHGELVETPGAKQPFELKATKIEIEGA STPDYPLQKKRHSFEYLRTIAHLRPRTNTFSAVFRVRSLLAYAIHKFFQERGFVYVHT PIITGSDAEGAGQMFKVTTLDINNPPRKEDGTVDFSKDFFDRETNLTVSGQLEGETYS MAFRNIYTFGPTFRAENSNTARHAAEFWMVEPEIAFADLEDDMELAEDMLKYIINYCL ENAPEEMEFFNNFIDNTLLDRLNNIVSSDFAHVTYTEAIDILSKADQKFEYPVKWGND LQTEHERYLTEKVFKKPVFVTDYPKDIKAFYMRLNDDNKTVAAMDLLVPGVGEIIGGS QREERLDYLENRMKELGLKMEDYWWYLDLRRYGSTRHAGFGLGFERAIMYITGMSNIR DVIPFPRTVHSAEF" misc_feature 52329..53720 /locus_tag="ClothDRAFT_1986" /note="asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932" /db_xref="CDD:179678" misc_feature 52386..52631 /locus_tag="ClothDRAFT_1986" /note="EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318" /db_xref="CDD:58588" misc_feature order(52404..52406,52458..52460,52545..52547,52629..52631) /locus_tag="ClothDRAFT_1986" /note="putative dimer interface; other site" /db_xref="CDD:58588" misc_feature order(52413..52415,52419..52424,52440..52442,52479..52481, 52485..52487,52533..52535,52575..52577,52599..52601) /locus_tag="ClothDRAFT_1986" /note="putative anticodon binding site; other site" /db_xref="CDD:58588" misc_feature 52665..53708 /locus_tag="ClothDRAFT_1986" /note="Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776" /db_xref="CDD:29821" misc_feature order(52692..52694,52698..52700,52710..52712,52725..52727, 52743..52748,52755..52757,52767..52769,52788..52790, 52797..52799,52803..52805,52809..52817,52821..52823, 52914..52919,52923..52931,52965..52967,52974..52976, 52983..52994,53055..53060,53085..53090,53106..53108, 53586..53588,53595..53606,53697..53705) /locus_tag="ClothDRAFT_1986" /note="homodimer interface; other site" /db_xref="CDD:29821" misc_feature 52809..52823 /locus_tag="ClothDRAFT_1986" /note="motif 1; other site" /db_xref="CDD:29821" misc_feature 53019..53030 /locus_tag="ClothDRAFT_1986" /note="motif 2; other site" /db_xref="CDD:29821" misc_feature order(53022..53024,53028..53030,53046..53051,53487..53489, 53496..53498,53631..53633,53640..53642) /locus_tag="ClothDRAFT_1986" /note="active site" /db_xref="CDD:29821" misc_feature 53631..53642 /locus_tag="ClothDRAFT_1986" /note="motif 3; other site" /db_xref="CDD:29821" gene complement(53925..56741) /locus_tag="ClothDRAFT_1987" CDS complement(53925..56741) /locus_tag="ClothDRAFT_1987" /EC_number="3.2.1.91" /inference="protein motif:PRIAM:3.2.1.91" /note="PFAM: glycoside hydrolase family 48; type 3a cellulose-binding domain protein; KEGG: hch:HCH_02465 RTX toxins and related Ca2+-binding protein" /codon_start=1 /transl_table=11 /product="Cellulose 1,4-beta-cellobiosidase" /protein_id="ZP_05430126.1" /db_xref="GI:256005157" /db_xref="InterPro:IPR000556" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR010916" /translation="MKLRYKVRRRRRIITCCGIIAAVIVVSTLIITIKNSFKPSRQSS NSNVTYSKENVQSVYSDRFIALFEDIQKQGYLSEEGIPYHSIETLLVEAPDYGHLTTS EAMSYMVWLGATYGKLTGDWTYFKDAWDKTEQYIIPDPERDQPGVNSYIPTQPAQYAP EADSPEKYPTPGDINAPTGIDPIADELASTYGTKAIYQMHWLLDVDNWYGYGNHGDGT SRCSYINTYQRGSGESVWETIPHPSWEDFRWGQVNNGGFLKLFGNFGEPVRQWRYTSA SDADARQIQATYWAYLWSKEQGKEKELQPYFEKAAKMGDYLRYTFFDKYFRPIGVQDS GRAGTGYDSCHYLLSWYASWGGDINGTWSWRIGSSHCHQGYQNPMAAYALAKESIFTP KSKNAKKDWEQSLDRQIELFLYLQSAEGAIAGGVTNSWSGAYGKYPEGTSTFYDMAYD PHPVYNDPPSNRWFGFQAWSMERIMEYYYLTGDSRVKELCKKWVSWAIENTRLKSDGT YEIPSTLEWSGQPDPWTGKPSENKNLHCTVTEWTVDVGVTASYAKALIYYAAATEKHE KKIDDKARETAKQLLDRMWHNYRDKKGVAAKEPRADYKRFFDEVYIPHDFSGINAQGA EIKNGITFIDLRPKYKEDKDYKMVEEAIKSGKDPVMTYHRYWAQAEVAMANAMYHIFF EQKKDGLVPGINSDDSNSSSETQKSETPDYTPDSLSTSDATITESPANTNSPDENPSP QNTSAPTNVPLNPANTPYNSSNAAPNSPNTPARPSNTTAGSPAGNNTVGRLILQYANG NGSDTTNTINPRFKLINNSGSPVKLSDVKIRYYYTIDGEKGQQFWCDWSSAGNSNVTG KFVKLSSPKNNADYYLEIGFTEGAGSIEPGMSVEVQARFSKDDWSNYSQANDYSFSAS ANDYGNSNHIALYISGRLVSGNEP" sig_peptide complement(56658..56741) /locus_tag="ClothDRAFT_1987" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.881) with cleavage site probability 0.467 at residue 28" misc_feature complement(54699..56567) /locus_tag="ClothDRAFT_1987" /note="Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011" /db_xref="CDD:110959" misc_feature complement(54117..54365) /locus_tag="ClothDRAFT_1987" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" gene 56984..57469 /locus_tag="ClothDRAFT_1988" CDS 56984..57469 /locus_tag="ClothDRAFT_1988" /inference="protein motif:PFAM:PF04024" /note="PFAM: PspC domain protein; KEGG: cbc:CbuK_0644 stress-responsive transcriptional regulator" /codon_start=1 /transl_table=11 /product="phage shock protein C, PspC" /protein_id="ZP_05430127.1" /db_xref="GI:256005158" /db_xref="InterPro:IPR007168" /translation="MKNGLVRSKYDRVISGVCGGIGEYFNIDPTIVRLGFVIATVLFS GLGLFAYIVAIFVIPEADSAANGFTDYAQKGFNDYYDPDKDFSKVLEDDEEYIKKDSH GGKTFVGICLIVLGLVSLLREHFREYISKFIHIDFKILVSLLLIVVGALIIFRGRRRL P" misc_feature 56987..57169 /locus_tag="ClothDRAFT_1988" /note="PspC domain; Region: PspC; cl00864" /db_xref="CDD:186227" gene 57466..58431 /locus_tag="ClothDRAFT_1989" CDS 57466..58431 /locus_tag="ClothDRAFT_1989" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430128.1" /db_xref="GI:256005159" /translation="MKKNNSGIFFGLFIIFIGIVLILSQFGMLDLDKIVNFLSDHIST IISLLLIVTGVNLVFDKYNGVKFFAWTAFFAVLLISGCIYGGATENKIERSTDKAYIR PFAEEKLPETEEGRLKMKLSGQNLKIGSTESGLIKGDMTDSGVQYKVDYKKNNKVADI DFKMESGFSLENVKNLVSMNGSDSKSWTTEEPLEVLLNTDVLWDIDLKFGGTDGEIDL SSLKVEEFELDGGAGNIKLILGDRHPSTKVDIDAGAANFKIFVPKNSGIKVEVDGLLS SVSFKDLTLEQTKKKTYVSPEYDNAKNKIEIDIDIGAGSVEINGI" misc_feature <58132..58419 /locus_tag="ClothDRAFT_1989" /note="Predicted membrane protein (DUF2154); Region: DUF2154; cl12089" /db_xref="CDD:159749" gene 58479..58649 /locus_tag="ClothDRAFT_1990" CDS 58479..58649 /locus_tag="ClothDRAFT_1990" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: bcj:BCAL1947 RNA polymerase sigma factor" /codon_start=1 /transl_table=11 /product="RNA polymerase, sigma-24 subunit, ECF subfamily" /protein_id="ZP_05430129.1" /db_xref="GI:256005160" /translation="MPDFGTFVLRYFQDLSIKEIASIVDIPEGTVKSLLSNGLKELRK LMKDGVRGDENL" misc_feature <58497..58607 /locus_tag="ClothDRAFT_1990" /note="Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171" /db_xref="CDD:100119" misc_feature order(58506..58508,58524..58529,58557..58559,58563..58568, 58572..58580,58584..58589,58593..58595) /locus_tag="ClothDRAFT_1990" /note="DNA binding residues" /db_xref="CDD:100119" gene 58636..58797 /locus_tag="ClothDRAFT_1991" CDS 58636..58797 /locus_tag="ClothDRAFT_1991" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430130.1" /db_xref="GI:256005161" /translation="MRIYELRQIFRVYGRVYNGGLDENLSGMMKTHLLECEKCRTEYI ETKKVIENL" gene 58841..59428 /locus_tag="ClothDRAFT_1992" CDS 58841..59428 /locus_tag="ClothDRAFT_1992" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430131.1" /db_xref="GI:256005162" /translation="MNKKNIAKKAAGKKDKRNFKSFISGIAAVVFFLMFLLTGSIVAF TSLASTYLPEVPVVKQLKDVQNEYNAIKRQNEEMAKLNEILKKENEEIKKENEELKIR IKEIGGVSIPEYRTSEGINDEYNQKIQEIVIKFIRAMYRGDIETARKISTEEFKQELA QNAKHYLMINKGDILFTCITNVAKKWKLVRGVCKA" sig_peptide 58841..58987 /locus_tag="ClothDRAFT_1992" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.934 at residue 49" gene 59727..60116 /locus_tag="ClothDRAFT_1993" CDS 59727..60116 /locus_tag="ClothDRAFT_1993" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: sat:SYN_01303 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430132.1" /db_xref="GI:256005163" /translation="MGVMDYLRKRKIEKKRAARKKAVKNAAIGAGLGAAVGVTAGILL APKSGKETREDIARNAKKATEAVSENTKKAVDKVSETSKKAVDTIRTTINEAKAKIAE RKAAKARKEAAATEEVEDGGESTEVKE" sig_peptide 59727..59849 /locus_tag="ClothDRAFT_1993" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.945 at residue 41" ORIGIN 1 ggaagaaagt gctgctgcaa gtgaagagct gtcaagtcag gctgagcttt tgaaacggtc 61 cattgcaaaa ttcaagttaa aaaatatggg aaaaatgaca tccaacagat ataaggaagt 121 tagtcctgaa ataatgagga tgcttgaaga ctatacggaa aacaagcaac cgaaaagtta 181 cagtaaggaa gaaaatggag aatatagtga tggaaaggaa acagctgaga aggatgttgg 241 aggtttaaaa cagaagatat tgttgtctga cagtgagttc ggtaaatact aggaaaacgt 301 aaaataaaaa tacgtaaagc agagtgaatt ttgacattta ctctgctttt tttaaaatac 361 caaaaaaggc atgtccgaaa aatttttgaa atctatacgg caatttttct gaaatttggt 421 tttatcaaat ttgacgaagc atatatgata taataaacta ataaagcgga taaatataga 481 tttacttaaa attaaagttg taaattgatt tttattaatt gaggcaggag gatgctatga 541 ggctggttaa cagtttggga agaagaaaaa ttcttttgat acttgctgtt attgtagctt 601 tcagcactgt tctgttgttc gcaaagctat gggggcgaaa gacttcaagt actttggatg 661 aggttggttc aaaaactcat ggtgatttga cggcagaaaa taaaaacggc ggatatttac 721 cagaggaaga gattccagat cagcctccgg caaccggggc cttcaactac ggtgaagcgt 781 tgcaaaaagc aatttttttc tatgagtgtc aaagatccgg aaagctcgat tcctcaactc 841 ttcgcctaaa ttggcgggga gattcgggac tggatgacgg aaaagatgca ggaattgatc 901 ttaccggcgg atggtatgat gcgggagatc acgtaaaatt taatttgccc atgtcttatt 961 cggcggctat gctggggtgg gcggtgtatg aatatgaaga tgcgtttaaa cagagtggac 1021 agtataacca catattgaat aacataaaat gggcttgtga ttattttata aaatgtcatc 1081 cggaaaagga tgtgtactat taccaggtgg gcgacggtca tgctgaccat gcgtggtggg 1141 gtcctgccga agtaatgcct atggaaaggc cgtcgtacaa agttgacagg tcatcgccgg 1201 gttccacggt tgtggcagag acgtcggcag ctttagctat agcatcgata atatttaaga 1261 aagtggatgg tgaatactcg aaagaatgtt taaagcatgc aaaagaactg tttgaatttg 1321 cggacaccac aaaaagcgat gatgggtaca ctgcagccaa tggtttttat aattcatgga 1381 gcggatttta tgatgagctt tcctgggcag ctgtatggct ttatcttgct accaatgatt 1441 cttcatattt ggataaagcg gaaagttatt ctgacaaatg gggttatgag ccacagacga 1501 acataccgaa gtataagtgg gctcaatgct gggatgatgt gacttatggc acttatcttc 1561 ttttggccag gattaaaaat gacaacggaa aatataaaga agcgatagaa aggcatcttg 1621 attggtggac aaccggatac aacggtgaaa gaattacata tactccgaag ggacttgcat 1681 ggctcgacca gtggggatca ttgaggtatg caaccacaac ggcatttctg gcatgtgttt 1741 attccgattg ggagaacggt gataaggaaa aagcaaaaac ttatctggag tttgcaagaa 1801 gccaggcgga ttatgctttg ggaagcacgg gaagaagctt tgttgtgggt tttggagaaa 1861 atccaccgaa aaggccccat cacagaactg ctcacggttc atgggcggac agtcagatgg 1921 agcctcccga acacaggcat gttctttatg gtgcccttgt gggaggacct gacagcacgg 1981 acaactacac cgacgacatc agtaattaca cctgcaatga agttgcctgt gactataatg 2041 caggttttgt gggactgctt gcaaaaatgt acaagcttta tggcggaagt cccgatccca 2101 aatttaacgg tatagaagaa gttccggagg atgaaatatt cgttgaagcc ggtgtgaatg 2161 catcgggaaa caatttcatt gaaataaaag cgataattaa taataaatcg ggctggcctg 2221 caagagtatg tgagaattta tcctttagat attttatcaa cattgaagag attgtgaatg 2281 cgggaaaaag tgcaagcgac ctgcaagtga gctccagcta caatcagggg gcaaaactgt 2341 ccgatgtaaa gcactacaag gacaatattt attatgtgga agtggatttg tcggggacaa 2401 aaatatatcc cgggggacaa tcggcataca agaaggaagt gcagtttaga atttccgcgc 2461 cggagggcac ggtgtttaat ccggaaaacg actattccta tcagggactt tcggcaggta 2521 cggttgtaaa gtctgagtat attccggtat atgatgccgg ggtgctggta tttggaaggg 2581 aaccgggctc agcatcgaaa agcacgtcta aagacaatgg tttgtccaag gcaactccca 2641 cggtgaaaac tgaatctcag ccgacagcaa aacacactca aaatcctgcc tcagacttta 2701 aaactccagc caatcagaac agtgtaaaaa aagaccaagg cataaaagga gaagtggtat 2761 tacagtacgc aaacgggaat gcaggtgcta cgtcaaacag tattaatccg aggtttaaaa 2821 taattaacaa cggtacaaaa gccataaatt tgtccgatgt caagattaga tattattaca 2881 caaaagaagg gggcgcatct caaaacttct ggtgtgattg gagcagtgcc ggcaattcaa 2941 atgttacagg aaacttcttt aatctttctt caccgaaaga aggagcggac acctgtcttg 3001 aagttggttt cggaagtggg gccggaaccc ttgatcctgg tggaagcgtt gaagtacaga 3061 taaggttttc aaaggaagac tggtcaaact ataaccagtc aaacgattat tctttcaatc 3121 cgtctgcttc cgattatacg gattggaaca gggtgacgtt gtatatttca aacaagcttg 3181 tttacggcaa agaaccttga tttatctgta cgcaacatgg ctaagatagg cttttgcaat 3241 accgatgtaa tattcggatt ctcttacaat gtgattaatt acaacagagg ctgtcaaatt 3301 gtttgccact gcggcactct cttttgccat gcagtttagg aagtttacga aggtttgact 3361 ttgacgtagt gttatttcaa taatatttgc aattttttgt accaattcag aagttatcac 3421 atagcctgat ctgttcagtg tctcaatata ttgcagaatt gtggcttctg tcgcgctgag 3481 aatcttttgg tattcatcca gcttttctgt gaacttctct tccaagtcct gtacaatttt 3541 tctgattacc acggtatgct ctgcttcttg tcttttccaa aattcagctt cttccagaat 3601 tcttatgtga ttcttgtcgc cgtagcaaaa ctgcattgtt catacctcca ttttatatag 3661 ttgctaaggt aaacgtaatt tattatatgt tggaagataa agttttgtga cggcaaagaa 3721 gaaatcaagg tatggggaaa aagagtagac aaaacggtgt tcagagaaaa ttaaaatttt 3781 gtcaatattt aagatttaca tgtcaggttt tgacctgata atatagaaag aaaagagttt 3841 aaaggaggtc aagcaaccat atgggattga atgaaacacc atctgcaaac cgtcttcata 3901 taggattctt cggcaaaaga aacgcaggta aatcaagtgt tgtaaatgct gttacgggtc 3961 agaatctggc tattgtttcg gacgttaaag ggacaaccac agaccctgtt tacaaagcaa 4021 tggagctttt acctttaggg ccggttgtga taattgacac tcccggaatt gatgacgagg 4081 gaacattggg agaaatgcgt gtgaaaagga gccgccaggt acttaacaaa accgatattg 4141 cagtattggt aatcgatgcc acgtgcggca agtctgaaga tgatgaaaaa ttgattgaat 4201 tgtttgagaa gaaggacata aagtatgttg ttgtttacaa caaggcggat ttggaaggac 4261 atgaagaaac ggtgggcgat aatgaaattt atgtcagtgc caaaacgggt tacaacatta 4321 ataaattgaa ggaaaaaatc gcatctcttg ctgttaccga tgatattacc cacaaaatag 4381 tgggtgacct gattagtcct tccgattttg tcgtacttgt cgtacctatt gacaaggcag 4441 ctcccaaagg acgtcttatt ctgcctcagc agcagaccat tcgtgatatt ttggaatcgg 4501 atgccgttgc gattgtggta aaagagaacg aacttaaaaa tacgttagac agccttggca 4561 aaaagcctaa gcttgtcatt accgacagtc aggcctttga aaaagtggcg gcggacacgc 4621 ccgacgatat ttatcttact tcgttttcca ttctttttgc acgatacaag ggtaatctgg 4681 aaattgcggt aaaaggagca aagacgctcg attctttaca agacggtgat accgttctca 4741 tctccgaagg gtgtacacat cacagacagt gcgatgatat aggcacggtg aagcttccaa 4801 ggtggataaa taattacact aaaaagaatt taaactttga atttacgtcc ggtacggagt 4861 ttccggagga tttgacccgc tataaattaa ttgtgcattg tggcggctgc atgctgaatg 4921 aaagggaaat gaaataccgt tacaaatgtg cggtggaaca gaatgttccc attaccaatt 4981 acggaatttt gattgcatat gtgcatggaa ttttaaaaag aagccttcaa atcttcccgg 5041 acatacttgc agaaattctt tagcggttaa attggttaaa tttataatta atgaatatat 5101 taatgcggtt aaattattaa tatattatgg aatcttactg taaaatattt ctgtttttaa 5161 ttgaagacaa caagacggat atgatataat ttatatgaaa tatatataca tataaaatgt 5221 atgcgaaaat aaacagcaaa tagaagtcgc atttccatat acttttcttt atccttatat 5281 catgcttcat tttctgcaaa catccggaaa cgaagattcc atattttgta tattttgatt 5341 tgtaatgaat taaaaattat aaaaattgaa ttataaaatt ataaaaatta atgtattgta 5401 aattataaat gatttatata aaagtatgtt ttaagggggg ttattattaa tgaagaaaat 5461 ggggttgggc agatttagca ataaatttgt cctgactgtt ttgctgttct ttttgaccgc 5521 cgtgctgctg ccgtcgtctt cttttgaatc aaaagtacag gctgcttctt cgcctcgtta 5581 cggcggtgca tattataatt acggagaagc tttgcaaaaa gcgattcttt tttacaaggc 5641 caatcgtctt ggagatttgc ccgatgatta catcctgcct tacagggctg acgccgcaat 5701 gaccgacggt caggatgtgg gtctggatct taccggagga tgggctgatg ccggagacgg 5761 aatcaaattt acccatccca tgtcctatgc cgcgggccaa ttgggctggg ctgtgtatga 5821 atatcgtcag gcctttgaaa aggcagggct gttggatgat attctggacg aaataaaatg 5881 ggctacggac tttttcatta aagctcatcc ggagccaaat gtattgtatt atatgtgcgg 5941 ctacaatgat tccgaccact cggtatgggt tccccacgaa cttttggatt atgtgacgga 6001 cagaaagtcc tttgtgttaa acccgtcaac cccgggctcg gatgtggcag gacaaactgc 6061 ggcgtgtctg gctattgcat caataatatt tgagccgaca gatcccgaat atgccgaaac 6121 ctgtttgacc catgcaaagc agatttttga gtttggtgat aaatacagag gcaaaaatcc 6181 tctggatgtt ttatacccgt ccggaggtta tctggatgat ttggcctggg gtgccgtgtg 6241 gctctacata aaaaccggag attccactta tcttgagaaa gcaaaatcct tcctgcctgt 6301 tacttcattg ggcggagggc atacccattg ctgggatgat gtcagctacg gtgctgcgct 6361 taaaatagcc cagcttactc atgacgaagg atatgccgcc atggtcgaaa agaaccttga 6421 tttctggttg cccggaggag gaatcactta cactccggga ggcctggcat ggctttcacc 6481 gtggggttct ttgcgttatg catccacagc tgcgtttttg gcctttgtgt gggctgacga 6541 cccaacggtt ggaacaccgt caaagaaaga aacttaccgt gcttttgcgg aaaaacaaat 6601 aaactatatt ctcggagata accctcgaaa aggaagttat gtggtgggat ttggcgagaa 6661 ttctccaaaa catccgcatc acagaacggc tcatggttcg tgggtaagta tgcttgaagt 6721 gccgagtttc catcgccaca ttctctacgg cgcattggtt ggtggaccga gttccgatga 6781 cagctgggaa gatgatattt ccgattatac ccggaatgaa gtggcaaccg attacaatgc 6841 aggttttgta ggggctttgg caaaaatgta tgacatgtat ggaggagaac cccttgaaaa 6901 ttggcctcaa cctgaagatt tcagagcacc ggaagacgac attgttgaat acttctgccg 6961 tggctggata atttacgaag gctatggaac cttaaacttg ctgcttcagg ttaacaaccg 7021 ttccggatgg cctccgacaa tgaaggataa gttgtctgtc cgttacttca tggatttaac 7081 tgaagtgttt gagtccggag gaactgtgga tgacgttcag ataagtcttg gacagaacga 7141 gggagcaaaa cttataggtt tgaagcatta cagggacaac atttactact ttacggttga 7201 ctttacggga accatgatta tgcctgccga gtgggagatg tgtgaaaaag atgcccatgt 7261 aacaatcaaa tacagagacg gcataacagg ttctaatgaa aacgactggt catatcagaa 7321 cttgagaaag gatccggatt atgatgctac atcctttgca ggactgactc cttatatacc 7381 tgtatatgac aacggtgtgc ttttgtgggg tgaagaaccg cctgccggcg gtgatgatcc 7441 cgggtcttcg ccgccgccga ctccaactga gccggtaatt gtgtatggtg atttgaacgg 7501 cgacggaaat ataaattcca cggattttac gatgttaaag agagcaatat tgggtaatcc 7561 ggctcccggt acaaatttgg cagccggtga tttgaacagg gacggtaata caaattcaac 7621 agacttgatg attttaagaa ggtatttgct aaagttaatt ggttcgttac ctatataact 7681 tatgtgaatt ttaatcaggt gttgcagaaa aaatcctacg gatggaatgg tcatccgtag 7741 gatttttgtt atgcctgtat tttttgagca tctgaacaag ttaatatata ataaacatat 7801 attataagga tggaatggct tttgcaatat atttctttaa tattgaagca tcagtagagt 7861 ttaccgaacc gtcattattt acatcggcgt tttcaagttg tttgccggag agagtcgtta 7921 ttctgagaat atgcctttta agtgcggaca aatctgtcga gtttatcttg ccgtcgagat 7981 tgatatcgcc ctttggcttt tttggtgttg gacttgggaa gggtgtcgga gttcgttcag 8041 gaataggtgt ataatagtta accgaggaca gataagacct ggcttctctg tgccttgtgc 8101 tgatatgctc tataagttgg gtgagagcct ggttaaattg tgcttcaccg ttggtgagat 8161 aagtgtagcc ttttatttct ccctcgcttc ccacggtgta tgggcggatt agctcgtgaa 8221 gcctgcgagc tttttcgatt acattaaatt ccctgaagta gatgttcagt gtgttttcta 8281 tttcggtgtg gtagatgtgc ttgtagaccg gatcatctat taaattgcga atcagcggcc 8341 agtttctgct aatttcatct aaagagaagc tgggcggttt tatgccccat ggattggtgg 8401 aggaaaggga gaggttataa tcccatggga taaataccaa acgaccgtta tcggccaaat 8461 cttggtaaag ataatggttt tttgtgaccc agccataagt gtcaaaattt acgatagtag 8521 tattgattgc cagccatttt aagaaagaat cggtattgaa aacagcttca aggtccgctc 8581 tccatttggc tgggtcggtt ttgggagcgt tcaatgcggc gacaagggct tgaaggtcac 8641 tccagtcgtc agctttttca ttggttttct tttcatatcc gcgtttatca aatattgtca 8701 ggtctcctcc aggtgcttgc tgacctttat agagatttcc gttggggttt tcgaattgat 8761 attcgagcat cttgtcggaa ggatcctcga acactgtgta taatccccaa taaacagggc 8821 cgtttcccgt atcaacgtac actctgtaga aagcgcagcg aggtgcggga atgccggcat 8881 cgcggaaaat gtcactggtg agtttatccc tcaggaatga aggatcatac cagttgttgt 8941 tgaatatgag ttcgtcaaag ccgtaaaatc tttggttgtc tatttcagga tagtcatctt 9001 cgaacttgtc aaagtttaag cggaaaggat atttgtggct catgctcatc atggccccgg 9061 tcaatgtact ctgtcccttg tatctgattc ccacgtgcca ccaggtgtga ttgttgaatt 9121 ttaccgttgc aggcacataa ataggatctt cgttgctcat cataaatact ttgaagacat 9181 cattttccat gcgctgaaaa ttttcgggac tgatgatgat atcgatacgg tttactttgt 9241 cttcgggaaa taccactgaa tagttgggcg ttgctttttt gccgtgggtt tcttccgtcc 9301 agccctcagg tctggatgca gcccaaactt gtggtccggt cagacacaca acaagaagca 9361 tcatgcttgt tgtcagtgcc gtcaacttaa aaaatttacg cataatttta cctcccataa 9421 attaatttta tcgataataa ttgatttatt gcttccggtt tgattcgaaa acacttggca 9481 gtcggttttt aagtatacgg atgccttgta aaaaacataa aaaatgttat atatcttcaa 9541 tatatattcg tagaaaaaat aattttgtgg cttaaagtag agcgaactaa aaatgagttg 9601 ggtttcatta tgttattata acttgaaaag agtgacagat tatagtattt taattatata 9661 gtattttaat attatatggt attacttcaa tgcaaaggtt tttgtttgcg ataaaactat 9721 tacacagaaa atatagggat tggaggagaa gataatgaaa aaaatagcta ttacgatatt 9781 aacggtattt atgttaactg tttttttggc aaatgtgggt tatgcaattg atataccgct 9841 tcgcgtagtt gtaaatgggg aagaggtgaa tttcccggat gcaaagccgt ttattgatgc 9901 aaacggaaga acacagacac cggcaaggtt tattggagaa gctctgggag cgacggtaac 9961 atgggacgga aatgcgaaga aggctgtatt taagatgaat ggaacaacgt tggagttgtt 10021 tattgggaaa aaggaatatc agctgaacgg gcaaaagaag cagatggata cggaagcatt 10081 gttgatagag ggaaggacgt ttgtaccggc tcgttatgtg gcggaagcat ttggcgcaac 10141 ggttagttgg aatgctgcaa ttaagacggt gtatataaat atggataaga cgggtaaggt 10201 ggaaaatgaa ggtgatacta gggaagtagc cggatttata gtgccgaagg ggatagattt 10261 aatggttgca ggtgcagatg aagattctgg ttatgaagcg gtttttacga tctccttttt 10321 aaggaagaat gttgaaaagc agaaagatga tatggagaag atattattac aaaagtttag 10381 tgaagatacg gtaaaagaaa ttatgagtgt tgtgagatca aaggtaaatt atacagatgt 10441 tattgaagag aggtattttt acgacaaaaa aactgaccaa tatatgtata tgcctaagtc 10501 atggccgact agaacatcca caattacttt atttatatat aggaaaggag ataaaccttt 10561 ttaggataaa aagcgaattt ataatttatt ctaaaaaggg gggaattcaa tgaaaagaat 10621 attatgttgt ataatattgt tgtgtatttt ggcacctttt ttgttgatga atgcatatgc 10681 agtaagttat aaaagtgcaa aagaagcaat agatgatgct aatgacttta tatttcagaa 10741 aatgggctat gaaaattact atttgtttaa aattggtaat atggatataa atgagaaact 10801 tgctcaatat ggttcagaaa cattctacaa caggccggta tttgtatatg gggacagtgt 10861 ggaagctagt aaaaggacga caacaggagg ccgggatata gttaaaaaag ttaatggtaa 10921 ggatgaatat cgtgcattag ggtatgcagt agatggttca gtttttccaa atcctgcctt 10981 cctatatgat aatgaaggcc atgcagcgaa ggacaagaag tgggttaaag aaccgtggaa 11041 tggtaaaaat atcaaatatt tatatggcga ggatggaagc attataaaaa aaactttatc 11101 agatagtgtt cttaattata taaaaaactg gatccaaatt aacggtttaa cacctactga 11161 agttgaagct tgtacaggca aaagaaacta tttcgtggaa aatgcagttg gtgtaccgga 11221 aaaattaaag aacaattttg aagactttct gtacataata caacctccga cggaacatgc 11281 atggggactg ggtatagcat tttactactg gaacggatat aacaacctca actataaatc 11341 gttcctcata aagccatttg atatggttgc tgatgatttg gatgttggtt tttatacgat 11401 acctggaagt gtgacagaag gcagcaaagt attggttgca gtaaaagtta aatcacactt 11461 cgatatagat ttggaaaacg ttagcttcaa atggaacatt actacgaaag acagcgatga 11521 taaagatgtt ccattagatg cgggaaaata cgaacttcaa tttgccgatt cgtcaaataa 11581 taataatcaa agtggaacag taaatatatc tgcagaacat aaggaaggac ttttttatgc 11641 tcagtttaaa atgcctgacc gtgatgtgta tatagagttt gtaataaatg aagacggaaa 11701 aaatcctgtg gaaagtaata tggaaaataa tactgtttct acggtggtta aagctgaaaa 11761 gcctataaat atgggagtta aaaaatatga tttgccatat tatgcattgt ccagagagat 11821 aagctatcca ttggcagacc aaaatattgt agttaattta aaaaagccag gtagtggctg 11881 gtggagtgga aatgccaaag tagatgcttt taatgtaggt atagacacta agtttttaca 11941 caattaccaa gtaggaagtc cggttcttaa agatgaagaa gacgatgtaa ttattagttt 12001 gccgaatgtg atagcaaaaa tccaaagaag tgactttgga gatgaccctg aaaacaaaaa 12061 gtggttggct ggtaataatt caactgatat attaacggca gctttaaaga cattctatga 12121 tgtctttgta ttgaaagagt ataaatatga aacgaaatgt aatagacatg aagactgcga 12181 agcggaaggc tgttccggct atgtaaagga aacaggttat gcaaggggca gtagaagcgg 12241 aactgctccg atagaagtaa atacatacgt atacaatggg aaaaaagatt taaacaaaaa 12301 gcaatatgaa aataaaattg tcaataatta tgacaaagac tttaaagcaa gaattctatg 12361 gacaaacagt cctatcaaat tcaatgtaat acgttatatg tgtgacttgg atgtaaacgg 12421 aaacgcgata aattggagag ctgtgcccgg caaatatgaa agggagtttg tgcagcagtg 12481 tagtgcagat attgactgga atatagcaag atcaatgcaa caagattacg agcaggcccg 12541 gaaagcggca agagaaggta aacaagacaa gtcattttat aacaaggcgg tatttgcgac 12601 agataaaaac ctgcaacgtt atgattaccc gataaaatca ggatattact ttaatccgac 12661 gggtacatat acatttgaaa ttacaactgt tacttacaaa aataaccaaa atgatacaga 12721 agagcacaaa aagcttgtaa atgcattagt aaactctttt agatatgaat cgaacttaat 12781 atatgttgat gacaacggta atcctgtaaa tattgcaaat ggatcctaca aaactctggg 12841 agtattaact gcagcaaaaa atacgggcat tggtggtaaa aaactaatat ctgtaaatcg 12901 tgactacaaa aaggtaacgg atgagatata ctacgattct aagaggacag aggatgaaaa 12961 taaaaacgga agtcatgatt tttggaaaat gtcaatggaa ggttattctt tgtcaggaag 13021 cttggacagt tataacaagt acaaataccg ggaatatgtt gcaggtggga aagtatttaa 13081 aataactgaa acaacaaagg taacatttat aataaacgaa ggaaatgcaa aattttatac 13141 tcatcccaaa atgcctgatg gtgaatatta tataacagta aggctttctg acatagactt 13201 aagtaaaatg tccgggatgg actacagttc gataaaagat gtattgaagg gagtaatttt 13261 agacagaatc aaagtcaacg taaaaggttc aatatatggt gatataagtt aataataaat 13321 tttatattta atttaaaaaa attagtgcta aaaataacaa ctgaccgtgt tatcctgaaa 13381 agtgtgtttg cacttagttt tcaggggaca cggtttttgt tagcttttat acttgtgaat 13441 tttagtttat tcaaaatcag tacatgatta aatgttttgt ttttcttgaa atatgtgcga 13501 aattgttgta aaattccatc taaataatcc taaaagttga tataggagga aaaagaggga 13561 tgaaaaaaat agcaataatg atattgataa tattcatgtc aacccttctt ctgacaaatg 13621 taggatatgc aattgatata ccgcttcgag tggttgtgaa tggggaagag gtgaaatttc 13681 cggatgccca gccgtttatt gacgcaaacg gaagaacaca gacaccggca aggtttatag 13741 gggaagcttt gggagcgacg gtaacctggg acggaaatgc gaagaaagct gtattcgaga 13801 aaagtgaaac aaccttggta ttgtttattg gtaaaagaga atacgaggtg aacgggcaaa 13861 agaagcagat ggatacggaa gcgttgttga tagagggaag gacgtttgta ccggctcgtt 13921 atgtggcgga agcatttggt gcgacagtta gttggaatgc tgcaattaag accgtgtata 13981 tagatatgga taagacgggt aaagtggaag ttgaaggtga taccagggaa gtagccggat 14041 ttatagtgcc gaaggatata gatttagcag ttgggggttc gaaagaagat tctaactatg 14101 aagcaacgtt tacaatatct tttttgagag ataatgtcga gaaacagaaa gatgatttag 14161 aaaaaatatt gttacaaaag tttagtgaag atacagtaaa agaaatcatg agtgttataa 14221 gaacaaaagt aaaggacacg gatgttattg agaaaagata tttttacgac aaaaagactg 14281 accaatatat ttaccttgcc aagtcatggc caatgagagg gtccacaatt tctctctatg 14341 tatataaaaa gggatataaa cctttttaag attggaggaa aaagagggat gaaaaaaata 14401 gcaataatga tattgataat attcatgtca acccttcttc tgacaaatgt gggttatgca 14461 attgatatac cgcttcgcgt agttgtgaat ggggaagagg tgaatttccc ggatgcccag 14521 ccgtttattg acgcaaacgg aagaacacag acaccggcaa ggtttattgg agaagctctg 14581 ggagcgacgg taacctggga cggaaatgcg aagaaagctg tattcgagaa aagtgaaaca 14641 accttggtat tgtttattgg taaaagagaa tacgaggtga acgggcaaaa gaagcagatg 14701 gatacagagg cattgttgat agagggaagg acatttgtac cggctcgtta tgtggcggaa 14761 gcatttggtg caacggttag ttggaatgct gcgattaaga cggtgtatat aaatatgaat 14821 aagacgggta aggtggaaaa tgaaggtgat accagggaag tagccggatt tatagtgccg 14881 aaggatatag atttggtagt tggacctggt acgaaagatt ctagctatga agcaacgttt 14941 acaataaact ttttaaaaaa cgatgtagag aaacagaaag atgacatgga aaaaatattg 15001 ttacaaaagt ttagtgaaga tacagtaaaa gaaattatga gtgttgtgag gacaaaggta 15061 aaggatacgg atgttattga agaaagatat ttttatgata agaagactgg ccaatacatg 15121 tatatgccta aatcatggcc gttaagaggt tctacaatta ctctgtatat atacaaaaaa 15181 ggagttgtgc cattttaaga tgcaaaagca aattaaaata ggaaaatata tacaaccata 15241 atatcaacaa tatcaacata tacatagaaa aggtgaaaaa tatatgaaca gattaggcgc 15301 ggaaattgga agactgagaa aagaacttgg aattactcaa aaacagcttg ccaaattggt 15361 gggtgtgtca gaaggattta tcattgatgt agagtcaggc agaaggatac tcaatgaaga 15421 cctcataaag aaattttcca gagtattgcg gggagaagtg ggaaagctgg aattatatga 15481 acctaaccaa gacaagccgg aaccggacag aaatgtggtg aaggttgttg aaaagcctgt 15541 acaggatatc tggaatgatg ccctttcggg aattcttatg actgtgcctg tataccgtta 15601 taaaatggac aaagctgttg atgcaaagca gctacctata atacagaata aagttgaagg 15661 ctttcccaag gataaagtgt tctatctgat tattgaagat gatgatatgt ccggttttag 15721 aatacttaag gacgatcttg ctttggttta caaaacccat gacattgata aggatggaat 15781 ttattttgtt gattacaaag gaaagcgtac ggtaagacag ataaaagaca tcggaaacgg 15841 caaattgttg cttgtcagca acagcggaag acttataacg gatacaatct acagaaaaga 15901 tttaaacgtc ctgggaagat tgattcgaat cgaaattatg ctgtaaagtc aagaccttaa 15961 attttcaatt ctgttatttg caagtctgtc tgcttgactg aaacttaatt tatgggtgct 16021 taagcttttt gcaacacgaa ttacagcacc catttttata tacttctcag cgtgttttta 16081 tttctgccaa ttttttaaaa taagcaacgt aaaaaaagat attcccaaaa ctcaaataaa 16141 tggggttccg ttcaggcagt caggggcaat agttttctta tatcttgact tttttacaag 16201 tattatataa taaactccta aaacatttag agaggagaca taatctatga aatcaaaaag 16261 aatcttggtt gtactggtag caactgtaat ggttttttca ctgatttcat gcaatttagg 16321 tcttgcattg tacattaatg ccaaagccgg tgagagctac aagtatcatg ttgaaaccgt 16381 ccaaacagtg gatgtgaagc aaaacggtca aaagataaca actaatcaaa atatagcctt 16441 tgactttatt gcaaccgtta atgaagtgga ttcggaaggc aatcttacag tggagtataa 16501 atatgatgcc atgaaatttg atatggatgc aaatgggata aatgaatctt ttgattcaaa 16561 agatgcaaat tccgataatc cgatggctgc gatatacaac agctttatag gcaagggttt 16621 taccgctaaa atgactaaat atggtgaagt caaggaaatt ggcggtgttg atgacctttt 16681 aaattcaata gtggattctg tggatttggg tgatgatgaa ggagcacaga atttaaaaga 16741 aaagataaaa gaaagtttgg gaggaagctt tagtgatgaa gcaatgaaat catatgttca 16801 gtcagcagtg atatttcctg aaaatgacgg tatgaaggtg ggagactcgt ggactgctaa 16861 caacagcatt aaatccatta ttgatgtaaa tatgaccatt acatatactc ttgacaaaat 16921 tgagggggac actgcctata tttcggttga agctgatttc aaaacggacc cttccaagcc 16981 tattgaatat atgggaatgg aactggtttc agatttatcg ggtacgatga caggagacgt 17041 aaaagttaac actaaaaacg gctttttgtc tgaaggagaa attattcagc aaatatcagg 17101 taatatgagt cttgtaatac cggcaatgga gggtattgaa agccagacgc tggaattgcc 17161 catggagtca aaagtgacta ttacttattc gacaactaaa atgtaattta atagttatag 17221 gataataatt aaaagcagaa ggagaaaatt aaaaagaagt tgacaggagt gattcttgtt 17281 gacttctttt ttcgcaattc gttttcaaag ttttcatgtt taaacgtgcc catgccaagc 17341 aaataatatt acaaaaatat tatttgaatg ggatgggaca aaaggaatgc taaagaacaa 17401 acagttgtta atggctttaa gtgttttttt gattgttttt acaacgactt atgcatttgt 17461 atattacaac gatggtttaa ataaaaataa tcggaaaatt aatgacaatc aaaatattca 17521 gataaagcac tttttaccaa atgagaacgg taataatgaa aatggcagcg aaaataataa 17581 tgaagaagaa agtctatcca gcccccggcc tgaaagaaaa ccggtaaagg taaaaggcct 17641 gtatatcacc gggacttccg ccggaaacaa aaagtttatg gaaaggcttg taaatcttat 17701 caatacaacg gaactgaata cagtggtcct ggatgtaaaa gaggacggaa aagtcaatta 17761 tgcttccgag gtggagagtg taaaaaagat tggtgcatac cacgagttgt ataatgtgga 17821 tgaagtgata aagcttttgc atgacaacaa tatatatgta attggaagaa ttgtttgctt 17881 cagggataac tatctggcag gaaagagagt ggaccttgcc ataaaacgca aggacggatc 17941 gatatggagg gaaaacggaa gtatagcgtg gacaaaccca tataacaaag aggtctggag 18001 atacaatatt gacatagcga aagaagcggt aaagaaaggt tttgacgaga tacagtttga 18061 ttatgtaaga tttcccgcag caggaaaaaa tgaagttgat tacggggaaa atcctatccc 18121 taaggctgat gcaatatcgg gctttcttaa agaagcggca agtgaaataa ataaaatggg 18181 tgtgccggtt tcggcagata tatttgccat tgtttgtgaa actccgggtg acaccgaagg 18241 cataggacag gtattggaga ggattggaat ggatatagat tatatatctc cgatgatata 18301 tccttcccat tttgccaatg catcccgtgg gatgatggga aacggaaaag gtcagtctat 18361 taacggtata ctttttacgg caccggattt aaagccgtat gaagttgtat ataatgttct 18421 tttgaaaaca aaagacagaa tatcaaaagt ggagggatat agagcaaagg taagaccgta 18481 tcttcaaggt tttacggctt cttatcttcc gaagggttat tatcagcatt atgggccgga 18541 gcaaataagg cagcagataa aggcggtcta tgacgccggg tatgaagagt ggatattctg 18601 gaatgcggca aacacttaca cggagtcagc atttgccaga gaataatttt aaaataaata 18661 aaacttttat tgttattttt tcgtctaaat aatattatta aatatatacc aaatataata 18721 atctatgcaa aaagtctata tggtatttat ttgataatga caacggatat atttatgtta 18781 taatcttaat aatagcaaaa agtatatctg atttatcaaa aacaaaaatc acaacggggg 18841 gtcaatatgt cagccaaaaa tgcacaaaca attttaagca acaaatgttt ttcagtaatt 18901 ttagtggtat tggttttagt ttttctttag cagcctgcaa agatacaggt gtccaggtaa 18961 acaatccggc acctactgca caagcgaccg ataatggaga agcaaacaat ggcggtaata 19021 cggacggcga agctcctgaa acttcagaac cgagtgaaga aagtccggta ccgaacaatt 19081 ccggcgagga tgccaaacct gtaaagaagg atatcaaggt aaaagcattg tatcttacag 19141 gatggactgt gggaagtgat gaaagactgc agcattatgt tgatcttgca aacaggacgg 19201 agattaatgc ctatgttgtt gacatcaagg atgatgacgg atatgtcggt tatgagtcga 19261 atataccggc agtgagagaa ataggcgcat ggaagagtaa gtacaatgtg gacaaagtat 19321 tgaaaacctt ccatgataac aatattcatg ttattggaag attggtgtgc tttaaggacc 19381 ctgttttatc ttccaaaaag ccggagttgg cggttaagag cgtaaatgga ggttcctggc 19441 gtgacaatca taatcttaca tggctggacc cctataacaa ggattcatgg ccttatttga 19501 ttgagatagc caaggaagcg gttgaaaaag gttttgatga aatacagttt gactatatca 19561 gatttcccaa tgacggaagc aaaaagagca tgagctttaa taccggcggc aaggaaaagc 19621 acgaaataat aaatgagttt ttggcttatg ccagagagca gcttccggga gttgtcctgt 19681 ccgcggatgt gtttgggata atactggaga gtccggcaga taccgaagat atcggtcaat 19741 atcttgaaaa gatagtaaaa gatgtggatt atatttcgcc gatggtctat ccgtcccact 19801 atgccgttgg acagatagtt aacggtgttc agttcatgaa gccggatctt gatccttatg 19861 gagtggtgta tcaaagtctt gttaagtgca ataacagact ggcacaggtg gaaggctaca 19921 aagccgatgt aaggccatat atccaggact ttactgcatc gtggcttggc aagggttatt 19981 accagagtta cggacccgag cagctaagac agcaaattca ggccgtttat gatgcaggct 20041 atgaggaatg gatctgctgg gatgcgaaca atacgtactc ggaagaagca ttcttgaaag 20101 agtaaacctt atgctttaga atagacttta gaataaaatg atattgtgtt attattgtgg 20161 atagcaaatg gattttttca tttgctatct gtttttttat cttctttttt aaataattct 20221 gattttcctt ttcttgcttt aatatctcat tattatgtta aataactcct tataatgatg 20281 atttttttca gcttgacttg taatagataa atgatacaat atacagtatg acgctatacg 20341 aaactacaca aaatgtagtg aattagtgag gaggctaata taatgaattt aaccgaaaac 20401 gcaattaaag tcctgaaaaa aagatatctt gcgaaggatg aaaacggaaa tctgctggaa 20461 gacccggagg gaatgttcag aagagttgcc aggactgttg catctgctga caaagagtat 20521 gtctcagagg aagagcttaa aagtatagag caggaattct atgatatgat ggtaaatctt 20581 gattttttac cgaattcgcc cactcttatg aatgcaggaa gacccttggg acagttgagt 20641 gcatgttttg ttttgcctat agaagataca atggaaggaa tatttgaaac cataaagaat 20701 gctgcgctta tacataaaag cggcggtggt accggtttta gtttttcacg cttaagaccc 20761 aaaggagctt cggtaaactc caccggaggg gttgccagcg ggcctgtgag tttcatgaaa 20821 gtatttaacg ctgccacgga ggccgtaaaa cagggtggaa ccagaagggg ggccaatatg 20881 ggcatactcc gtgtggacca tcccgatatt gtagaattta taacatgcaa gaagaacaac 20941 gccgacatta cgaactttaa tattagcgtt ggtataacgg aagaatttat gaatgccgtt 21001 gaaaacaatg aatattacaa tcttgttgag cctcatacag gcaaaatagt tggcaagcaa 21061 aatgcgagag aaatatttga tttaattgtt gatatggcgt ggaacaacgg tgagccggga 21121 ataatctttt tggacaggtt aaacaaggac aatgttactc ccgaactggg ggaaattgaa 21181 agcacaaatc cttgcggcga gcaacccttg ctgccttatg aagcatgcaa tctgggttca 21241 atcaatttaa gcaatatgtt aaaatatgtt gacggaaaac cggaagttga ttttgccaaa 21301 cttagaacta cggtatggaa ggccgtacat ttcctcgata atgtaataga tgtaaacaaa 21361 tatcctttgc ctgaaattga caaaatgaca aggggaacaa gaaaaatagg actgggagtt 21421 atgggatggg ccgacatgct ttgcaaactg aatattcctt acaactctca gagttcgata 21481 gatcttgcgg aaaaaataat gcattttata caggatgagt caagaaaagc ttccatggag 21541 ctggctgaaa agaagggagt attcccttat tatgataaaa gtatttacaa gaaccttgga 21601 atcagagtaa gaaatgccac tactacaacc atagcaccca cgggcacgtt gagtattatt 21661 gccggtgtgt ccagcggaat tgagcctttg tttgcaattt catatataag aaatgtaatg 21721 gataatgatg aacttgtgga ggtcaatccg gtcttcaagc aggtggctaa agaagaagga 21781 ttttattccg atgagttgat gagaaggata gcaaagaaag ggtcaataag aggatttgac 21841 gagataccgg agtggattca ggatgtgttt gttaccgccc atgacatttc tccggactgg 21901 catgtaagaa tgcaggccgc tttccagaag tataccgaca atgcagtatc aaaaaccgtt 21961 aatttaagaa acgaggctac ccgcaaagac gttgccgatg ctttctggct tgcttacaag 22021 acaaactgca aaggtataac gatatacagg gacggcagca gagatttgca ggtacttaat 22081 attggaaaag tgaaaggcaa ggaagaaagc gtttcaaaag ccagggaaga aggccctgca 22141 aagcccaaag agcagatcaa gcctgtatcg ggcatagccc caagaccgag atcggagata 22201 gcgacaggct tcaccgaaaa ggttaagata ggctgcggta atttgtacat aacagtaaat 22261 tatgacgact atggtatttg tgaggtattt acgaatactg gacgggcggg aggatgtcct 22321 tcccagtcgg aagcaacggc aaggcttgtg tctatcgccc ttcgttccgg agttgattat 22381 aaatacattg ttgagcagct gaaaggtata agatgtccgt cgacaataag gcagaaaggt 22441 ttgaaggttc tgtcttgtcc cgacgctatc ggaagactca ttgaaaaggt tgcaaaattg 22501 cagaacgggc agaagatcat ggcaactgag gctcatatca cagatgaaca aagatttcaa 22561 cggcctacgg caaataccta ttataaattt gaagatgcgt cggaagagga agaagtggat 22621 tttagaattg cagagctgga aaatgataca gaagaaaatg atacagaaaa tgcagacact 22681 gcggtttgtc ctgagtgcgg cagaaaagtt gagcacgagg gcggctgtgt ggtgtgcaga 22741 aactgcggat attcaaaatg cggataattg tctgagattt tgacgcaacg gggagtgttg 22801 caaacttaat tggttttgcg gcactccttt atttgtactg ataatacaaa ttaatgggtg 22861 tatagcttga tattcatttg tagaattttg ctattaagat gttacagagg aaaaacataa 22921 taaacaggat tttcaggttg acttcttagc cttcaaaaca taacattgtg ttatagaaat 22981 attatttttt attattattt tgttgggggt caaaagtttt tatggagaga cgttgcaaaa 23041 gacttgtatg tattttgttg tcatttcttg tgattgccgg tgtttttacg ttcagtggtg 23101 caaaaaccga gccctggagt gcctatcaaa agtttatacc caatgagaca ccggttgtaa 23161 aaaggcatct taggggagtg tggattagta ctgttgcaaa ccttgactgg ccgtccgtag 23221 agacacgaaa aatagaaaat ccttcggaac ggataagaaa aactaaagaa gagcttgtgg 23281 agattttcga caaggctgtg gagatgaatt taaatgccgt tttcctccag gtcagtccgg 23341 agggggatgc attctacaaa tcagatatag tgccctggtc acgttatctt acaggaacct 23401 ttggagagga ccccggcttt gatcccttgg agtttgcaat tgaggaagct cacaagcgaa 23461 atctggagct ccatgcatgg tttaatcctt acagggtgtc gacaaacacg tcggctgcaa 23521 ccatttcatc tttaaaagtc gaaaaaagtg tgtacaagga acatcctgac tggattagga 23581 cagccatgaa caggtttgtt gtcgatcctg gaatacctga agcgaggcaa tgggtgattg 23641 accgtgttat ggaggtggtg aaaaaatatg atgtggacgg agtgcatttt gacgactatt 23701 tttattatga gcaatatgtg ggagagctga aggatcagga tacttacaac aagtacaata 23761 agggacagtt ttccaatata ggcgatttca gaagaaacaa cacgtatttg ctggtaaagg 23821 agctttcgca gaagataagg gcaaccaagc cctgggttaa atttggcatt agtccttccg 23881 gcgtatgggg gaacaaaagc gacggccaca gctacggttc caatacgagt gcaagtctta 23941 caaattacga taaaagtttt gcggatacaa agaaatgggt tcaggaggag cttatcgatt 24001 acattgctcc ccaggtttat ttcacttttg caaattccag agcaccttac ggtgagattg 24061 ctttgtggtg gtcggatgtt tgcaggggga aaaatgtgca tctttatata ggtcaggcgt 24121 tttataagat aaatgatgac agcgatcaat attttaaagg tgagaatgct gtgccggagc 24181 tgacaaggca attgaaattc aatgcggtaa aacctgagat aatgggaact gttttgttcc 24241 gttttgcaaa ttttaaagat tccggtaaac agcaggcggt aaatgccgta aagaatgact 24301 tgtggtcaca aaaagccttg attccaccaa tgccgtggaa gggcggcaat gctcctgatg 24361 cgcctatact gggaagattg gaatccctgc ccgacggagt ggaaatatcg tggatggata 24421 atgacccgga caccgcgtat tttgcaattt accgctttaa tgccggagaa aaaatggaca 24481 ttacctctga cagcagtgca tacaaactta ttgccactgt cagaaaaaac agtaacggtg 24541 tgcagaaatt tgtggattat ggggttttgg atgctgacag cgtatattat gttgttactg 24601 ctttggaccg gctgcacaat gaaagtgaag gacttgcaat aagcaccaat cagtccgaat 24661 attttccgga tgtcgggatg aaatattcct gggccgttga tgcaattgac atgctttatg 24721 aaaaaggagt tgtcaagggt gatgaaagcg ggatgttcaa cccgggggtg aacacgaaaa 24781 gagctgattt tactattatg attgtaaagg cgctggccct gaaagctgat tttgaagaca 24841 attttgccga tgtcaggaaa gatgcatatt actatgaggc ggtaggcgtt gccagggctc 24901 tgggaattgt aaaaggagac ggaaagaatt ttaatcccga tgccaatata acccgggagg 24961 atatgatggt tatcgtggtc aatgccctta aagcggccgg ggcaaagatt gacgaagccg 25021 atgagcaatt ccttgaaaat tacggtgatg cgaacagtat aagcggctat gcaaggaaat 25081 cggtggctgt tcttacgaaa gcgggagttg taaacggcta cgacgggaaa atacatccta 25141 aaagtctggc cacaagggct gagattgcag tggtagtatc aaagctgtta accaatattg 25201 agtatttata acaagacagg cgataaaaca gatgtcccta ctttttataa gtggtgggca 25261 tcttttttct tttaaagcga caagtatttt tttgacttat tgaaacagtg tagcgacagt 25321 aaaaatttac acaaacgaaa aatataacca catttcactg ataataattg atatatttgc 25381 gaaatcaata caagcaaagc atgataatta ttttgcacag tatggttata ctacttttaa 25441 ggaggtgtaa aaatgaaatt tcataaaatt gtcattgtga ctgccataac ggctgttttg 25501 tcttccgttt ctgtttttgc aactcccaag gctacagaga ccccgaaaac tgatacaacg 25561 cagcagaaga atcactgtga gcaaaaacgc ggaagtgaaa taaataaaga cagagcaaag 25621 gagaaaggct ccgatactca aatagatccc atagagaggc ttaaaaagaa gaaggcaaag 25681 gttaaggagc tttatgatgc aggaaagatt acaaaggaag aagcggatga tctcaatgca 25741 aaaatagatg cgaagattaa ggaaattgaa gagtttaaca aacttaccgt ggaacagaag 25801 cgggaaaaac ttaaaaaagc attcaaagaa aaaatcgaca aaaaggtgaa ggaaggaaaa 25861 atatcccggg ataaggcgga tgagatcatc aggaagttta acaagaaaat tgatgaatgg 25921 gatggaacgg gttatccccc atttatccat aaatcctgta taaaaaagca tagatgcaag 25981 caaagatgag tttttaaatt gtaaagctat atcaagggaa ttcgacctat tataaccggg 26041 tcgaattctt tattttgtaa aattattcaa ataaatataa tgtttttttg ttacttatta 26101 ttaaattttt atatactaaa tccattttta tgatataata ttgttagttt taaaaattgc 26161 ataataaatg caaatattct aagatattga gttatttatt tcttttgggg ggcatgaaaa 26221 aagaaaagct tttttccgta cttttattca tttttaataa gtaaatattt cctacatgtc 26281 tataataatc ctcaatttaa tattaatatt ataatattgg cattggctgc atcagctgta 26341 tttttcgatt gatgaattaa ctaattggca gggttgatat tttatatgat tctatagcga 26401 aaggaagtgt tgcaagttgg caggacctgt ttaaaacctg tgatacaaat agagaaaaat 26461 aataatattg ggggtaaata tgaggaaaaa ttttaaagta cttatttcca ttctgctgtg 26521 ttttatgatg ctttttgggg agatagtacc tgccggattg ccgtcggcca aggctctggc 26581 ggaaaccgat aatgttcttg aagttcagga ttcatctttt aatcaggaaa ataataattt 26641 ctcacccgaa aagactgttt cagaagatgt ctacgaggaa gaagaattgc ttcaaaaccc 26701 tgatgaagaa attccggggt taaaagctgc ttcttcgact atgagcgtat ccagtgtatt 26761 tagcatatcc ggtaaagttg tcctgccgga gggaaaagta gctccatccg gaggtttgac 26821 tgtaagagtg tatgctaaaa gcagctcaaa aactaacaat ataactgtta ttatccccga 26881 aggaaaaagc agtgctgatt acactgtgat tgttcctgag gcaactacgt atactttgta 26941 ttatcagaca tcgaattccg attatgtgga cacaggttat tacagtgtaa ttggaactgt 27001 cagaagctct tctgcggcgg atcagataag actgacagca gatgtgcctt cagagacgga 27061 tatagatctt actctcatag caaaaaggat tatttcggga actgtaaccc ttcctgacgg 27121 cgaaatcgcc ccagccggcg gagtgtcagt aaccgtaacg gcggtaagcg gatctgacaa 27181 ggcaacggct aatgtagtca ttccggaagg attgggttct gcaaattata cattaaaagt 27241 tcccccaagc acatcgggaa aaggatatct tgtcagctat caaacttcga acaaaattta 27301 tttgcagact gcatattaca gtatgcgcgg gtctgtaaga tacgacactc ttgcaacttt 27361 ggttgatgtt attgacgaag ataggaaaga tatcaactta aaccttattg caaagaaaaa 27421 aataaccggt actgtatctt tgcctgaagg tacggcacct aaagacggtg ttacagttac 27481 cgtatgggca acctatggtt cggataaaga ttctcagact gtgacaatac ctgagggggc 27541 ttcatcggtt gaatatgtat tgtatgttcc cgacggctcg ggttatacat tatattatga 27601 aacaacgaat gtggcatacc ttagtaaagg ttattacaac gaaaacggaa cggttaagga 27661 cagtaaagcg gcaacgcctg tggataccgt ttcgaaagat gcggcagata aaaatataac 27721 acttattgca aaacgtattg tttcgggaaa agtgtctttg ccaaaaggag ttgctcctga 27781 aggcggtata aaagtagaag taattgtggc attgaataat accaaaattg aaagtacaac 27841 aattacaata cctgaaggcg aatcggaagc cacttactcc atgtatgttc cgacaggttc 27901 gggctataat gtttcttaca agacatccaa cagcttgtat gtcgaacagg gttattataa 27961 aaagggttca acggtcagat atttaagttc agcaactttg attaccgttg aaaatgagga 28021 tctgaacgac atagatcttg aacttattga aaagagaacc atcagtggaa ttttgtccat 28081 gccgtccggt acggcaccca agggaggaat aagctttgaa attacggctt acaacagctc 28141 tactgaagca aaggttactg ttacaattcc ggaaggcgaa agctcggtac cgtattcaat 28201 aaatgttccg gcggatgaag ggtacataat caaatgcaaa ttgctgacgc ttcaggcaat 28261 atatatgaat gaacagtatt acagcagcgg cggtaccgta tacaatgtcg cttctgcttc 28321 gaaaatcagc actctcagcg gtaaccagcc gaatataaac ataatgcttc ttgaaaaaag 28381 aaccgtaagc ggtacattat cttttcccga aggatattat gctcctccgg gcgggataat 28441 tttcacccat gagaccgacg gaagaataac cttcatttat attccagaag gagaaaggtc 28501 cgcacctttt acaatttact acaatcctgg agtatacaaa ctttattacg aatgtgatga 28561 agatgatata tttgtttcac cgggatacta cagcaagggc ggtactgttg tggacaaaaa 28621 cagtgccgat gatattgacg tcagagaagg aaaccaggtg ggtataaatc tggttctgct 28681 ccttaagaaa accatatcgg gtaaagtggt tctttccaat ggagttgcgc cggaaggtgg 28741 ctatactgta aaagtaaagg cttccggaag caagggaagt gcggaacaga ccgttgtgat 28801 tccaaaagga gaaaagtctg cggattatat tctgtttgtc aaccccggag acaaatacag 28861 ggtatggtat gagacttcaa aagaatataa tttcgtaagt cctatgtatt acaattccga 28921 cggaatggta agagacagta gtagcgcatc tctcttggat ttaaccaagg aaaacaagac 28981 agatatagat ttgactctta ccgaaatgcg ttctgtcagc ggtaatattg ttcttccatc 29041 cggtgttgca ccgtcgggag gtatttcggc agatattgtt gtttccaacg gaaaagacag 29101 tggaaaagta acagtaaaaa ttccggcggg agaaagattt gcaagctaca ccgcatatgt 29161 tcctgcagga aaggactata aggttaaata tacggtagat gcaaaaagcg attatgctac 29221 cgacggttac tatggggtaa gcggaaccac gctcaacgca agttctgctg catctcttga 29281 ccttacttcg gaaaacaaaa ctgaaataaa tatgactttg atacctaaaa gaacaataag 29341 cggtacggta tctctgcctt cgggaatgac tcttggcagt gatacaaaag tgactgttta 29401 tgcaggggac agctacagca caactgttac aatacctaaa aacggttctt ctgtggaata 29461 tgctatcaag gttccgccaa acagtgcggg atcaggctat aaggtatatt acaaacttag 29521 ctccactact atgcttattt caccgggata ctacagcagc agcggaatga ctgcttcgga 29581 gattggagcg gagcttgtgg atgtaagcag cacagacgcg acggtagacc ttgtcctgat 29641 accgaagagc agtattaacg gaagcgtaat acttccggaa ggtgttgctc caaaaggtgg 29701 cttgaaagta actgttacag cttcaaataa taaaaacaaa gggtctgtta ccgttacaat 29761 accggaagga aaaagctcgg cagagtattc tgtttatgtt ccgtcaggaa ccggatatct 29821 tgtagaatac tcagttactg atgaagaata cgttaaaaaa ggttattaca gcacatcggg 29881 aactgtcagg gattcaagtg ctgcaacttt gattagcctt gacggagaga gcaagcaaaa 29941 tgtaaacctt acactgctta gaaacaataa aataacaggt aatgtcactc ttccaaaggg 30001 agttgctccg tcaggaggat taaaagttac ggtttgtgcc tccaactcaa cgggcagcgt 30061 taaaactacg gtaacaatac ctcaaggcta caatacaata agctatactc tttttgtacc 30121 gcaaggaaag aattataccg tatggtatga agcttcggac aggagattta tgccgacagg 30181 ttattacagc gacggaggta caacggttga taaatccaaa gctaagctta ttgatgcaac 30241 tatcaatgtt tcatcgatta atattgattt gattccgaag atggaagtaa gcggaagtgt 30301 aaaactttta tcggcacctg cacctgcagg gggaatcagt gtaaaactta caatagacaa 30361 caagatttcc agtgattcgg tggatgtggt gattccggaa gggtttatgt ctgctcctta 30421 tgccctttat gttccggcag gcgaaaacta catcttaaaa tacactacat caagttcagg 30481 ttttgtaagt cctggattct attccgaatc cggttcgaaa gagactgaaa aggaagcttc 30541 ctatctgaat ataacaggtg acaggacagg tatcgatata ccgcttatta ccaaaagaac 30601 cattcgcggt acgatattgc ttcctgaagg atatgctccg gcaggcggag tcagcgtaaa 30661 agtaactgcg caaagctcgt ctgataaaat aacggcaagc tttgtcattc ctgagggaga 30721 aaacgcagtg ccctacacat tgtatgtttc ctccggcaag gaatatattg taaaatacga 30781 aactactgat gaaaagtatg taagtacagg tttctacagt atgttaaaaa ccacccgtct 30841 ggaatcggaa gcggataaat tggacacgac cgaagcagac caggtgggta tcaaccttaa 30901 acttataagc aacaaatata taagcggaac tgtctcaatt ccgtcaggaa tagcaccttt 30961 cgggggcata aaagtaacgc tcaaagctac gaacggcaag gacacaaaaa ctgttaacgt 31021 tgtcatacct gaagtaagca gttcgacaac ctacaaaatt tatgttcctg aaggcaaaga 31081 ttatgaactc agttattcca taagcaacgg agacggaaaa tatttcccta ccggatacta 31141 taatggactt acagcaacca gggaaaaagg agaatgtgtg cttcttgacc tttccggcga 31201 aagcaaggaa ggaataaata ttacattgat acccaacagg ctggtcaccg gaagccttat 31261 attgccttcg ggagtggctc ctgcaggagg cttgaagatt actgtcaggg cttcaaacaa 31321 aagggattcg gtaccaacta cggtaaacat gcctcagggc agcagctccg tagtgtatag 31381 aatgtatttg ccggaaggca gtgattatac tatcggatat accataagcc atgaagatta 31441 tttgaacggt tactacaata ttaatgaaac ggttcttact caatctgagg caacaacctt 31501 taatgttgag aagagtgaca tcttgggatt aaacattgtt cttatcgcaa aaaggacaat 31561 aaccggtatt gtaagtctgc ctgacggcaa gacggccccg gcaggaggaa ttgatgttac 31621 gatatctgcc ggaagctaca gtaccaaggt gacaattcct cagagcaaaa actctgtgtc 31681 ttacacattg aaggtgtcac caaatgcagt cggttcggga tacgcaataa aatacgcaat 31741 tacctctgct acggattttg tccagaccgg tttctatggt gaggataaaa ctgtggcgag 31801 ggtacaggaa gcggatttgg ttgatgtcag cctggaaaac aaagccggta tcaaccttac 31861 catactggaa aaacgtgtta tcgccggtgt gttcaagctt gattacggtt atgcgccttc 31921 aggaggtatg aatgtcacaa tatctgcgac aggtaagaac gccgaaggca aaagcatgac 31981 ctatcagcag gtaatttact tgccgtttgg ccacagccag gcagaattta agctgaatgt 32041 ggatccaagc tattatgcta cgggttacaa gcttaaatat actatggatt ctgagtatgg 32101 ttatgctgaa atcggatatt acaatgatat agaaggaaca gtgcaaaatg aaaaagaggc 32161 aacattgatt tatgtggatt acaaggatca gttaggcaaa gaaataactg ccatcagcaa 32221 gaaccatata agcggtagtg tttctcttcc tgacggagca atagctccaa aaggaggaat 32281 aaaagtaagt gttcatgctg aagggccggg cggcagcggt tctgcaaatg ttactattcc 32341 cgaaggccag tccggtgcag gctatgtact gattgttcct ccgggaacac aatacaagct 32401 gtattacagc atggcaccaa ataacatgta cgtttcaagc ggatacttaa gttctgaagg 32461 aactgtttta gactctaaaa aagcagagct gtttgatgta aaaggagatg ttgacaacaa 32521 gaatattgta cttataccca agagaaaagt atccggagaa gtgacactgc cggtaggggt 32581 atttgcgccc aaaggcggcc ttaaagtgga agtgaccgtt caaagcagtc aaagcagtga 32641 ttcattgact gttaccatac cggagaacgg tcagtcgcaa agctttgagc tgtatctgcc 32701 gccacagaac ggatataaat tgttctacag tttagcttcc ggtaccacct atgtaagcaa 32761 gggatattat gctcaaagcg gtactgtcat agatgataag ctggcatcgg agatagattt 32821 gagagacaag gatttgaccg gtgtaaagct ttcgcttgta gaaaacaaca ttattaaagg 32881 aagcgtaatt ctgccttacg gtgtcgcacc tgagggagga attgaggtaa gaattactgc 32941 cgacaatggt aaattcaaaa atacaacgaa tgtaacaatc cctgaaaacg gcaataagat 33001 tgattatgtg ctgcctgtgc ctccggcatc gggatatagg gtatcttatc aggtttcaac 33061 cggacttgat tttataccta ccggctatta tggcagtgaa ggaacggtta cgtcctcaag 33121 cggagcatta aaacttgatt tgacttcggg aggaaaagaa ggaattgatc tttctcttgt 33181 ttactataac tcgataagcg gaaccgtatc cttgcctgaa ggagttgcac cgaaggaagg 33241 agtaacgctt acagtatttg cagccaactc cagaaacaag agagagacaa cagttacaat 33301 cccgagcggt aaaagctctg caaattataa tatttacatt cctgacggct atggatacaa 33361 ggtatattat gtcatgaccc cggatgtaaa atatgttgac aaaggattct atgcaggcat 33421 cgatacggtt accgatgaaa aagaggctgc caccgtggat gtcagcgggg gttcggtaac 33481 agacataaat cttactgtca ttgcaaaaag aacaataagc ggaaccatat ctttaaaaga 33541 cggcgaaaaa gcacctcaag agggtattgc tgtaaggata acggctattg acggagatga 33601 acagacagtc gtaattcctt atggtaaaag ctcggttgca tactcattga atgtggttcc 33661 aaatgcagca ggaaagggct acaaagtaag atttgaaacc attaagaact acggatatgt 33721 gcgttacggt tattatacaa aagacggcgc ggtaagaagc gaagctaatg ctgagtttgt 33781 ggatgtaagc agaggggaca aagacaatgt gaactttgaa ttggtacgtc cgcgtacaat 33841 aaaaggtacg gtcggacttc cggaaggtgc tgcggcaagc agggatataa ctgtaaccgt 33901 tatagcatcc aacagtattg acagcgcgga cactgttgtc tatataccga aaggctcaaa 33961 agaggccgct tataccctct tagttccgcc taatgacagc aatgatgaat acaaggtaag 34021 gtatgagaac tggcatgaca acagttttgc cgatattgga tactatggtt cgtcggaaac 34081 tgtcagaagt gctgatttgg caaagggagt caatgtaaga aaagaaaatg ccgaaggcat 34141 caatcttacc cttattgcca aaaagactgt ttcaggaaag atttcgcttc cttatggaac 34201 agcaccaaga ggtggactta ctgtaacggt ttatgctgag aataataccg ataaggttat 34261 ttcctatgta accatacccg aaggcaaaaa cagcatggac tattcattaa gcgttcctgt 34321 gggcaaagga tacaggatag gatatgaaat gtccataaaa aatgactttg ttccgtgggg 34381 atattacgga aacaagggca tggtctttat gcccggcgag gcctatctta tgaatataag 34441 cagtgatatt ggcggcattg atttggaact tatagaaaag aagtccatca gcggtaaagt 34501 aattcttcct gaaggaacag ctccaaaagg aggaattaaa atagaggtct atgctgaaga 34561 tgccggagac acttgggtta caattcctga aggacaaagc tatgctgagt atacgatgaa 34621 ggttctgccg agccttcagg gcagcggtta caaagttaaa tacgtagttt cgtcggatta 34681 tggccttgta ggatacggtt attacaacaa aaacggtacg gtcagaaaca gcaagctggc 34741 tgagccggtt gacgcaaact acaaagatgt tgccaatata gacattgaat taatgaaacc 34801 gagagtaata agcggaaagg tttctttgcc ggacggtgtt gcaccttcag gaggtatttc 34861 attaaatatt gcgatattta atgaaacaga cggaaattcg cagattatta caataccggc 34921 tggaaaatct tcggcaactt attccataag cgtgcctccg aatgacccgg gctatgagta 34981 tacagtcagg tatgaaaact ggtcgaacaa gatttataca acctatggat actataacag 35041 caagggaacg accaataata tgtcctatgc acagttggtg gatgtaaatg agaaggacgc 35101 ttcaaacatt gacatggttc ttcttaagaa ggccacggtc agtggagtta ttgaagtacc 35161 cgaaaatgca gtgcttccgg aggaaggact ccatgtaagg atatacgtat ccaacgatgt 35221 cgaaacctac tcagcgaatg tgactatacc ttacggtaca tcatcagtgc catattcagt 35281 gcatgtggaa gaaggaaccg gctacaggct gttctatgta ctggatagca atgaaagctt 35341 tatggaatac ggatattatg ctgacagcgg agtatatacc gataaaaaga tggctaaggt 35401 attcaacgta tataatcaaa acatcagcgg ctacaagttg aagcttttag agaagagaag 35461 aatctcgggt aaactgattg tgccggacgg tgcctttgaa aacgaaggct actttgaggt 35521 tgccattagt gcaacaaacg gatttgacac cggtacagcc aaagttctcg ttccttatgg 35581 taaggcagaa gcgaattata cattgacttt accggcaggc agcggatata tacttcagta 35641 cgagatttcc aagataaaag gatatacatc cgttggatat tatggtgcgg aaggtaccgt 35701 aagaaacaga aacgaagcat tagccctgga tttgagggaa actgatttaa cagacattga 35761 tatttccctg attcaggaca tgacgataag cggtacaatc agaattccac aaggaacggc 35821 tccggcagga ggcatcgaag ttgttgtaac agcaaccgat gaatccggaa acatggcatc 35881 agagaaagta accattccgg aaggcgaaag ttcggcggac tattatctga atgttccgcc 35941 aaacgctcct gattcaggat acagggtaag gtacagtgtg gcagctgata aatatgcggc 36001 tattggttat tacagtgaga gcggtacaaa ggcattgccg aatgaggcaa caccggtgga 36061 tgtaagcagt aaaaatgcgg aagagataaa tctggtgctt attgaaaaga agatagtgag 36121 aggtgttgta tccattccgg aaggggctgc cggaaaaggc gggctgcccg taaccataaa 36181 ggcgacaagc agattgttca gcgtggagga tgcggtaacg gtgaccatac cggaaggaga 36241 gagcatggct ccgtacacct tgtgggtatc accgaatgta gaaggagcag attatataat 36301 ttcctatgag gtaagtaata cggcttatat aaacagcgga tattacaatc aggcaggtac 36361 ggtagtggat attaatatgg caactcctgt tgacgtaagc aacggggatt ataccaatgc 36421 caatatttca ctgataagaa gtagaaagat aacaggtaaa ttgatacttc ctgaaggaga 36481 aaccgctcct aagggtggtt tgccggtaac agtttttgca gaaaaaacag gttataccgg 36541 ttacagagtg acaaagaccg taacaatacc tgaaaaacag agcagtgtgg actacatcct 36601 gtacgtacct gaaagtacgt caaaggcagt aaaacttaag ctccaggctt caaccggaaa 36661 cggaacggag gacaaagccg acgattatgt tttgaatacg gaagtctttg taccggtaat 36721 tgacggcagc ggaagttccg aatacaaagt gggttattcg tatactcagg atgaacagta 36781 ctttagaagc ggattctata ctaaggatgg aacagtgcct gcaataagca tggccggcac 36841 agtgaatgta gccaaaaagg atgttcagaa tgtagatttg actctgctta aaaagaacag 36901 aacaataaaa ggagttgtca aacttccgga cggcaagacg gcttccggaa atattgaggt 36961 ggaaataaca gctgaaaacg atgcgttgga ctttgctccg cagaaaacag taacaatagg 37021 caaaggaaaa tcatctgttg aatttgagat tgcagttccg tcacttgaca gctatcgcat 37081 aaaatatacg attaaatcaa caaccgacgg atatgtaacc agcggttatt acgcaacaac 37141 cggaaccgta ggaaaacctg aactttcaac acttgtaagc acctcatccg gaaatgtgga 37201 cggaattaac ttaaatctga tacccggcat ggaaataaga ggaggagttt ctcttccgac 37261 aggacagcag gtaaaccgca atgacttctg gctgtgggtt tcggcctcta atgagaatta 37321 tgaatcttcg gtatatgtca caatagctaa gggaagttct tcagcaaatt actctttata 37381 tgtacccgaa ggttcaggat atattgtgag ttactcaatt ctgcctctgt ttggagagta 37441 tgtgcaaaag ggttataaca atgcaagtgt aaccacagca aataaagaca gtgcgacaaa 37501 gtataacgtg acaaagaacc tgagtggtat caatctcaca cttttgcctc tggacagagc 37561 tatatcgggt actgtatcgc ttcctgacgg tacggcttcg gtgggataca caatccatgt 37621 tcccgccaac aagagaggca gtggctatca attggagtat tcggttgttt cgggcaatga 37681 aggcggtgca tacaaggaga aaggatactt tagccttgcc ggaacttcgg ctgacaaggc 37741 aaagacatca attatcgatg taagctcaaa aaacagcacg ggcaatgaca tgacactgct 37801 tgcagatacc atggtacctg tagatgcaat tatgctggat aagtatcagg taaccataca 37861 gagcggcaaa acggtaaatc tcaaagttaa atatttaccg gagaatgcta caaacaagac 37921 aattaaatgg acttccggca acacaaatgt tgcagaggtt tcgtccgagg gtgttgtcaa 37981 ggcaaaagca acgggaacgt cagttataac tgcaagaact cacaacgcag taataacagt 38041 atttactgtc agagttgttc cggccgaaag ttctgccttg agtattgata aactgtctgt 38101 gagcataaac cccggagaaa aggaacagct cgaggcaata ttcactcctc agagtgagga 38161 tgacaaagta atatggaagt ctgacaacac cgatgtggca acagtatcgg agaacggtct 38221 ggtaacggcg aaaaaatccg gtacggcggt aattacagct atgagttcga aagatccttc 38281 agtatatgca acttgtgaag ttgttgtcat aactcctgtt accggtgtgg aaattgacaa 38341 gaccaggctt gaaataaaag taggatataa tgaaaaactt acagccgggg tactgcccga 38401 aactgcaagt tataaaggaa ttacgtggat atcaagtgat gaaagtattg tcagggtgtc 38461 acaatccgga gaagtgactg ccgtgagtat cggaacagcg gttgtaaccg ccagcagcat 38521 atataatcct tctttgaagg cggtatgcac tgttaaagta ataccggttc ctgtagagga 38581 aataaaactt gacaagcaaa cagtcacatt gtatccggat gagtatatcc tgataaatgc 38641 ggaggtcctt ccttcgaatg cttcagacaa gagagttgca tggaagtcag agaatacaaa 38701 tattgcaact gtgacggcag aaggtctcgt aaaggcggta aatatcggtg aaacaaagat 38761 aattgcaacc agcctttacg attcatccaa aacggctgtg tgtgtagtta aagtggttgc 38821 aagaccggtt acaaaagtga catttaagaa tgtacctgag tccatactgg ttggccaaag 38881 caaagcgttg gaggtaaccg tatctccgtc caatgctacc gataaaacac tggtttggac 38941 atcaagcgat gaaaaaactg caacggtaac ccaggatggc gttgtgacag gaaagggagt 39001 cggaacggtt acaattaccg cagcatggaa gaacgacccg agtgtagagg cagtatgtac 39061 attgaaagtt gagccggtaa aagtaacagc aatcaaattg aaacaaacca gcatatcttt 39121 gggtattgga gacgaagtaa aacttgttgc cgaaataata ccggagaatg ccactaacaa 39181 agaaattata tggtcaacaa gcgacaggga tattgtaacg gtatcatccg acggagtggt 39241 taaagctgtt tccatgggaa gagctacaat aactgctacc agtaaagaat cctcaagcat 39301 taaagctaca tgcagcgtaa cagtgacagg aatagaagta agtcaggtaa gaattaacaa 39361 caaaccttca acgctggctg tgggaagcac ccacaaactg acagttacta taaatccgac 39421 aaatgcttcg gataaaacac tggaatggag ttccagcgat acatccatag caacggtaag 39481 ttcttccgga gttgtaacgg cgaaaaaggt cggtactgta acaattacgg taagcagcaa 39541 gtcgaaaccg tcctgcaagg attcgtgcac aataaaaata gttgaagcaa caccatcacc 39601 gacacctgcg gaaattgtca atgaacccgt tgtaattccg ggcggacctg gcggaggcgg 39661 cggaggagtt ccggttgctt ccatcggtgg ctcacctaca ccttcggcga caccgacagt 39721 gactccgaca gcaacgccga catcaacacc gtcagcagga aagactccgg cagcgagtcc 39781 gacaccggca ccggttgtta cggatacaaa cagtctggac ttctttacag atataaaggg 39841 tcattgggcg gcagaattct ttgctgattt gctaagaaga gaaatcgtca atggatatcc 39901 ggacagaact ttaaggccaa atgctccgat aaccagagcc gaggcaacgg taatggtagt 39961 gaaggcggca ggctttgaag tgtccgatag tataccactt acatgcactg ataaagattc 40021 ggtaccggca tgggcaaaac cctatgttgc aacggcaatg cataaaggtg tggttaaggg 40081 ttatgaagac ggatccttca ggccttcgaa ccgacttacc cgtcaggaga cagtggtttt 40141 ggtactgagg gcattcggaa tagaagaagc gcaggataag acccttgcct ttgctgattc 40201 ggataagata ccggcctggt cgagaggcta tataaagaaa gcagtggaat tgggaataat 40261 caaaggttac agcgacaaca cctttgggcc gcaaagggag attacccgtg ccgaagttgt 40321 taccataata tcaaagtgta ttcagcttaa gggaaggtaa aatcccaaaa ggcagaaagg 40381 ctgaattaaa aaacggagtt gggataaaca ggtcccactc cgtttttttg tgtgttcaca 40441 gcatggctgc cagaggactt ccttctctta taatgtcttg tatttcatac acggatatag 40501 gaaacatggg aaaaccaaaa gcataaggag ttatttcgta cagttggaaa tatattacca 40561 atgctttgtc ggctatgtaa tagtcctgat tcggtcttat tcccttgaat tcaccgagga 40621 ttggaatttc gcgttccttt atctgccttt cgattatttt tgacagtgtg ccgacataat 40681 cgcttcccgg tttgaagagc tcttccagcc tgtactcttt gcctgtgctt atatcaaagg 40741 ttagtgattt aattatagtc aatccgtggg cggcagggta tgcaatggta taatttccaa 40801 tcgaaaggct aagcacccct ttttcattgg tctttatttc ataccagccc tggacggtca 40861 tttgagggga tttataccct tgctccagca gtttgcccgt ttgctcgtaa ataagttcat 40921 ttacagtttt tattatcctg gagtttatta tattctgaat gttaagggtc ttaaaacctg 40981 tggcgaaggg ataatcaata atcaggtcct gaaacggaga tacaattctt cttgtgaata 41041 tgtaaacggg attttgaata ttgttcattt tttactcact tcttttaaat tttactgata 41101 taataatatt cgtgagtgtt aaatttgtta cttgttgaag tgtaaataac agtatgttaa 41161 ttaatataaa aattaactac ggcagaagat gtttcattgt atgaagcaag agccgatatt 41221 aatcgataat atacacaaaa aaagcagatg tatacgaagt aatctactga agggagaatg 41281 atctggtgga agtccggaaa attaataccc ataacaggga gaaaaaactg gatgatatag 41341 tctatgacga ctttatttct acccttagac agataaagga aggaaatcat cagctcagag 41401 aagagtttat atcggaatat aaacccttca ttttgaaagt tacctcaaat gccacgggaa 41461 aatatatcga cacccgcaac agtgatgagt ttagcattgc attgtccgcg tttaatgaag 41521 caattgataa atttgacatc gagaaaggtt ataatttctt tctcttttct gagcaggtaa 41581 taagaaggcg cctgattgat tattcaagaa gcaacaaaga tgataaggaa tatccttttt 41641 cattttttga tgacgaatat ttttataaca atgaaaaact tttatccaag tcgtatattg 41701 gatttgaaga tattgaggca agggaagata ttgaagaatt aaagaagaag cttcaggaat 41761 ttggcataac atttctcgat ttggtgttaa atgttccgaa gcacagggat tcaaggcagc 41821 tttgtataag gttggccaag atgctggctg aggatgagca aatgtacaat gcattaatga 41881 agaataaaaa catacccaga aatgaattaa aaaagaaagc caaggttcac gggaggacca 41941 taggcaataa tagaaaatat attatagcgc tttgtttaat tttcagaagt aacctgaatc 42001 tttcaaagag atatttggag tattatacta tggacggagg aaagtgacct tatatgaaca 42061 gattgggaat aatatatgaa attcagggca tgaaagctgt agttctgaca agcgaaggcg 42121 aatttttgat tattcgcagg cgcaaagata tgaaggttgg acagcaggtg agttttgaaa 42181 atgaggatat atataatgtc aggggaaaga gatttttata tgttgctgcc gccgtttcaa 42241 gtgttgcggc agtgctggtt gtaatgtttc tgtattttca gtctgcattt ttgagtaata 42301 ccgataatat ttacggatat atatgcgttg atataaatcc cagcgttgag ctggtaattg 42361 atgaaacttg cagggttttg gaagttagac ctcaaaataa agacggagag caattgattt 42421 cgggattgga acttttggac aaaaatgttg aagatgttgt ttacgagctt attaacaggt 42481 ccataagttt tggttttgtc aaagctgatg ataacagaaa aattgttctt atcagcggtg 42541 ctcttaatga taaacggaac gaactcaaaa cgaaaaaaga aaacgatgag gctgaattga 42601 cggaattgct tgacaatatc aaagccaggg tagatagaat agataatatt aaagtgcgca 42661 ccataacggc aacttccagg gaaagaaaag atgcattgaa atacgggctt tccatgggaa 42721 aatactgcct ataccttgaa gcgcaggagt tgaacggcag cattaccatt gacgaagtgc 42781 atgatatgag tatttcagat atgatagaga aattggaaca gatgaagctg gcattaaaag 42841 atgaggcaag tccaaaactg caaaccacgc cgacgcttgg aggggaaact gcacaaatat 42901 cgccggaatc catgcaacat tccacagtgc ccgggttgcc ggaaactcca tcatcttcag 42961 agaagacaat cgcaccgaca ctccatggaa ctccaggtgt gcctgatgag aaaacattac 43021 agccttcaac gccgacagaa agctcagaat atgtgcaaga cggtacaaaa gggcttaaaa 43081 tacaatatta cagcagaaag ccccatgatt ccgcagggat cgacttcagc ttcagaatgt 43141 ttaacacggg aaatgaagca attgacctta aagatgttaa agtaaggtat tatttcaaag 43201 aagatgtttc gattgatgaa atgaactggg cggtatactt ttacagtttg ggtagtgaaa 43261 aggatgttca gtgcaggttt tatgagcttc ccggaaagaa agaggcaaac aaatatcttg 43321 aaattacatt caaatcgggg acgctttctc cgaacgatgt aatgtatatc acaggtgagt 43381 tttataagaa tgattggaca aaattcgagc aaagggacga ttattcctac aatcctgcgg 43441 attcctattc ggattggaaa aggatgactg catacatttc gaacaaactg gtatggggaa 43501 ttgagcccaa ttgataagaa aaactgccat ttggagaata tattacaaaa tatatttaat 43561 aaggttatat tcagatgcag tattgtgcta taatatgaaa ggattaatag tcaaaataag 43621 caaaggagag atatggtaca tatgagtctt tataacgaat ggcaaaagct ttgtgaaaaa 43681 cagaggacgg aagaggagaa caacgaattt tggaatactt accttgagaa agagatgaaa 43741 gtatatgagt ttattttgga gcaccacgat gaggttgtgg aaggaaaact tgcagagctt 43801 gcggaaaaat ttgacatgga acctgtggtt ttcgcaggat tcatggacgg cataaacaca 43861 agtttaaaaa atcccgtgaa acttgaggag cttggtgatg attcaaacat caggcttgaa 43921 gttgattttg aaaagctgta ttacaatatg ctggatgcaa aggcgtactg gctttataat 43981 cttccccagt gggacaacat attgagtcag gaaagaagaa acgaaatatt gaaggattat 44041 aacagggcac acattgcggt aagcaggaaa attggaagaa atgacccgtg tatttgcggc 44101 agcggcaaaa aatacaaaaa atgttgcgga gcataaaata aaaaaaagcc gctaaccgta 44161 taccattgaa ttttataccg gtaaattgta aaggccgcgg cggcaagtcc ggaagaatat 44221 aacaatgata gtaatgagca gaaagaagaa atattttgtc ttgcagaaat aggcttcatt 44281 ttaggccgat aactgatact caaggctttt atttaccctt acgccgatca tggtggcaat 44341 aaatactttt ataatgtctc cgggtacgaa agccaacgtt gatacaacat gaggccagga 44401 aaacagactt ccggttattt caaagcagag ccacggaata cctattgcat atactgccag 44461 catgccaccg acgatgcatg cagtccctac ttttaaggtg ccttttccgt ctcctttgat 44521 cagagaaatt actatggcac ctatcaaaaa accgataata aatccgccgg tgggacctgt 44581 caaatatgct attcccgctc cgcctttttg aaataccgga aggcctgcgg cgcccagggc 44641 aatgtaggtt gtcatgctta ggcctgcctg ctttggggta agaattacgc ctgccagcat 44701 cacgcccaag gtttgtcctg taattggagc gggaagaaca ggaagtgtga tgcttatcca 44761 gccaagcacg gtcatcaatc ctgtgaaaac agcggcatac atcatgtctt taagatactt 44821 gtttcgcatt gcaatattcc tccaattaga ttcaacatat cttgtatgtc aataaagata 44881 ttattatatt attaaataat tgtcaacata tttttaagtc aaggttgaca attaaatcaa 44941 aattaatttt cagagtattt ttgatgttaa ataagtgtgt agtaaaagta tatgttatat 45001 taaaaagagg ctttacaaag cctctttttt aatatgcatt agttttcgaa accgtatttg 45061 aaagcatctt tggttataat tatatccgat acattgagtt cattgatgta tgaagtaatc 45121 ttgtcgtcat acagatttaa atccagtaat tttccggtgt cataatcata tacttctctt 45181 aaatcattga aatatatgaa gtcctttgtt actaccgaac cgtctcttaa gacaacgtaa 45241 cctttatttt cgtcatagtt caaaagatct tttcccaaag catacggcgc atcaaaatcc 45301 ataagatttg caatcgtcgg aagaatgtcg atttgaccgc ctatggtgct tataacttca 45361 ggttttgact gatcgggata atgaattata aggggtactt tttgaagctt catccattcc 45421 ggctcactgt actccatgtc aagaagcttc ataagtccgt cggcctcaat cttttttaca 45481 gcagcgtggt ctccgtagaa taccagcagg ctgttgtcgt aaagcccgcg tttcttaagt 45541 tcagctataa attcacctat gcatttgtca agataatttg cggccttaag gtaattgcct 45601 atgtacgttc cctcaaattc tccgacgtca aaatcatagt cttcgaaata agtaaacgga 45661 tgatggcttg acagagttat ataaaagctg taaaaaggct ttgtagtgtc tattttatca 45721 aaagactgcc tgaagaagga tgaatcgctg agagcctgac catcccatcc ggcaaaatcg 45781 tccagtacaa aatcctcttc gttaaaaaat ctgtcaaagc cgagggacat gtgcatttca 45841 tccctgttcc agaaggtttt gtcaaaaccg tgcagcgagt aagtattgta tcctttttcc 45901 ttcagtattt tagccaggga atgataagtg ttttcaggat ataaatgata aactgcacct 45961 tcttttgcag gatacagtga gttgttggtt acaaattccg catcggaagt atttccgcct 46021 gacacctggt agaatacgtt gtcaaaataa aggctttcgc agataagcct gtttaaatta 46081 ggagttactt ctttaccgtt aatttttaag tttattacaa attgctgcaa agcctccatc 46141 tgaacgacaa tcagattttt atctttggca attcccttca gcctgctgtc caggctgtct 46201 ttttcattct tctttgtttc atacagggcc ataatggagt ttttatcctc ctgggtgaag 46261 ctgtcgtctt ccaggagatt ctcttcaatt aacagttttg tgttgtagta atgggaaaag 46321 agtactccca ggcttttggc cgagtagttg ttgctgtatg caaaagaatt taagttcgaa 46381 gtatggaaca ccgataaaaa tgtaaccatg cccactacca gaaaagctgc gaagcggtat 46441 actctccggg aaatatgcag ctttcgggtg tttttgttca aaagcagaac tccgatcagc 46501 ataaacggca aatcaacaag atatattaaa tccttaagca tgaattgact cagtatgctc 46561 tcgttgacgg aactcacaag cttgatattc agttgaaaga atacaggtat ggtgattaaa 46621 ttgtagtaat atctgaaaaa gtttgtatcg gctatcagca aaattgtcag aagaaaattt 46681 attgtaaaaa gggcaatgaa tctgaacttg ttgaaaacaa gagctataaa ggctgatatt 46741 atcagtaaaa ccgcgaaaga cgaaaggaac atggttatat tcacggaaga cagataagga 46801 accgtattca gttttgttgt aaattgaaaa taaatgcact tcagcataag gaatataata 46861 aacattatcc aataaatggt ttctgcaacg ttaaagcgtt gatttatgaa attttttagc 46921 cgctccattg tcatttacct ctctttttgc taattggaat ttgtcttaac taaggtatat 46981 aaacagctat ttaaaaattt accattatat tatacacaat tttattttat aataaaacgt 47041 taaaaattta ttaaagaaat tctaaaataa ttataaacaa attttaaaca attgtttagt 47101 atgtgtattg ttaattttgt tgtgtttaaa atatttatca agtggtatta ataaatatgt 47161 cattagtaaa taatatgaag tggaggaatg gtaaatgaaa aagctttgga agtgttcggt 47221 atgcggttat attcatgaag gggaggatgc accggaaaag tgccccaaat gtgatgcttc 47281 gaaggacaaa tttgtccagc ttagcgatga agatgccaac aaggtgtaca tgtctgacag 47341 aacaaacgat attcatatgg agattgtcaa ccttgcagca aggataatag cactctgtga 47401 agaaggtata aatataaatc tggacccgcc ttgtgtggaa gcattcaaaa gagccaggaa 47461 tgaagcatgg gttataaagc aaagatcaaa agccgaaatg gaaggtcata tgaaaaaggg 47521 aaaatggtaa gcctgtagaa gacggtaaaa ctattctttt tcccttataa gccattctaa 47581 aaatttcaca tagtatcctg ttatcggaag aaagacaagg gcgcttaata tattgaaaat 47641 cgtatgggca ttggcaatca gacgggtttc atcctgcccg atgccgtaag ttatggcctg 47701 aatcataaaa gcaaaaggct taagaaaaat aaatgctatt atggttccaa taacgttata 47761 gagggtatgg gcccatgcgg ttcgctttgc ggaaattgaa gtgccgatac tggaaagttg 47821 tgcggtgatg cacgttccga tattgtcgcc cagggtaaga ccgagggcgg attcaaagct 47881 tataaggcct gtattgaaaa gtacaatggt aaggccgaca gtagcgctgc tgctttgaac 47941 aagcatggtt gtcaccatgc ctgtaagaag gcctatgagg ggattctgtc cgtaaactct 48001 gaagagttca taaatattgt cattttcttt tatatatggc actcccaaat tcagtatgtt 48061 gagccctgca aacatgatgc caaggccggt aagtgcccag cccatgtttg caggggttct 48121 tcttttggag aaaaaagcaa taagaagtcc cagtccgatt atgatgtatg aaaaattggt 48181 aagtctgaaa gacatgagct gggctgttat tgtggttcca atgtttgcgc cgtatattat 48241 acccaccgcc tgggtcaatt tcaacattcc ggaatttacc agaccgacgg ttataacagt 48301 tatggccgta ctgctttgaa ccagtgccgt aagaacagta ccggtaaggg tggccagcgg 48361 cactttctcg gtaaaaaggg agagatactt cttcatcctg cggatgtttg ctttctcgag 48421 acttgagctc atcagtttta cgccgtatac gatgcatatt gttccgatta ttatatttac 48481 aataactata acaagtctga aattcattct tcttttaaat accgttcctt tttaaaattt 48541 ttttaagcct gtttctataa ttaaagataa gcttgacaga acgaaattag aacaaaaact 48601 ttggacagtc aaaaatttgg tttttatttt aaaacttcag tataaagtta aaaaaaacaa 48661 catagtttat aggagaaaca ttacaagaaa aaaggtggtt ttttgtccgt ttttccaagc 48721 aatataatat acaacttttt aatagctttc ggtgtgattg tgggtgcaag cctgtttgca 48781 gggctgggag ctttgataaa cgaccatcct cccctaaaaa cgatgtttca gatagcaagc 48841 tccattaaaa tatgggcggt ggccgttgcc cttggcggta cgttttccac ttttgaaata 48901 ttggagaaag gaatattcaa aggggaaata aggtcaataa tcaaacaggc ggtttatgtt 48961 gtagtggccg tgattggagc aaatgtcgga tacggcttta taagacttat ccaaaaatgc 49021 ggggagtcaa tgttcaaatg agaaaaattg cttataaatt ttttgtttgc tttgtcaccg 49081 ggctgatagg aggaattcta ttaggatgta ctttgatgag cacattggta agctacagga 49141 tagacaagta ccatgaggaa ataatgcttc tgaaaacccg gattgaggag agcgacgcca 49201 aatacaacaa gctcaaggaa tcctttgaca gtatgaacaa gaaaaagttt ttggtttccg 49261 atatacaggt gtttttgatt tttaaaggta atgaagaaga cgattttgac aaaatgcagc 49321 ttgaaaaata tataaaggac aggtatcagg accttttgtg gaaggaagtc aaaagcatag 49381 acatggattt ggtggtaaag ctggtggatg aggatattta caggattgaa aacaaaaatt 49441 acaggctggg agtaaacaga gttttaattt ccgatgtatt taaaatatgg gtgacggtta 49501 agaaaattga ctaaatttta tggtataatt atatagaaca acaattttgt tataagatag 49561 aggcgataat tatggaaatt gacactttca gggaaatggt cgaaaaaagc ggtagcattg 49621 tgttctttgg cggcgccggt gtgtctacgg aaagcggaat tccggatttc aggagcagca 49681 ccggaatcta tggacaaaag accaggtatt cctatccgcc ggaggttatg ctcagccata 49741 gcttttttat ggagcatacg gaggagttct ttgagtttta caaagaaaaa atgatataca 49801 aggatgcaaa gcctaatgcc gcccatattg cactggctaa gctggagaag catgggaaac 49861 tgaaggcggt cataacccag aatattgacg gactgcatca ggcggccggg tccgaaaatg 49921 ttattgaact tcacggaagc atccacagaa acaggtgcat gaagtgcaat gaaagctatg 49981 acctggagta tgttttaaac agtcccggga ctgtgccgct gtgcaaaaag tgcaacggaa 50041 ttgtaaagcc gtgtgtggtt ttgtatgaag agcctctcga taccgacagt atagaccggg 50101 cagtggatta catagagaag gcggacatgt tgattgtggg cggaacatcc cttgcggttt 50161 atcccgcggc ggggcttata caatattacc ggggggacag gcttgttctt atcaacaagt 50221 cgccgacgcc gtatgacaga agggcaaacc tgattataag ggacagcata ggtgcggtgc 50281 tgggaagcgt ggtttgacat aataaatgga ttgtctcact ctaatgagac aatccattta 50341 aagtatggat atcttttttt acggatatct atttttcaag caccgttact gtcttgattc 50401 tgacttcttc cttgggaacg gaaagttcgg taggattcga cggatttgga tcaacgggag 50461 tatttgctat tttatccaat acatcatagc cttctataag ttttccgaaa gctgcgtaat 50521 ctccgtcaag atagggtgcg tccccgtgca ttataaagaa ttgtgaggtt gcagagtttg 50581 gatcgttgga cttacgagcc atggatatta ctcctctggt gtgagacagt ttgtttttgg 50641 taaaaccgtt gttggcaaac tcacctttga tggttttccc ggagccgccg gtaccgtcac 50701 cgtttggatc accgccctgt atcatgaacc cttttattat tctgtggaaa gtgagaccgt 50761 catagaatcc ttcttctgca agggttataa aattgtcaac ggtttcgggc gcatattccg 50821 ggtacagttc aaggatcatt ttacccccgt cttccatttc aatctgcact tttggatgct 50881 tgacactgta ctttgatttg ttgcagccga cggtaaagac tgcggttata agacaaatta 50941 aaataattgc aaggaatttt gtattggtcc ttccaatcat ttcaaaaccc ccatatctta 51001 aaagttctaa agacatgata caacattttt atgggtgtgt ctacataacg taaagctttt 51061 ttccgaattt ctgaactcta tcagaatata actattggat ttgagactat taaatggtat 51121 aatgtgagtt gattctattg tgttgtcgtg attataggag ggaaaatatt gtggttgaga 51181 agatagacag gcttataatt ccgccggatt accatccgac tttgtcggtt agagagacgg 51241 aagcggcaat taaaaaataa aggacttttt tgagacggca ctggcagcgg agttgaactt 51301 aagcagggtt tctgcgcctc tttttgtaag acctgagaca ggcatgaatg ataacctcaa 51361 cggagtggaa agaccggtat cttttgatgt aaaggctatc ggcggaaata cagtggagat 51421 tgtgcattcc cttgcaaaat ggaagcgtat ggctttggca aaatacggat ttaaagtggg 51481 agaagggctt tataccgaca tgaatgccat aagaagggac gaggatttgg acaaccttca 51541 ttccatatat gtggaccaat gggactggga attggtgatt aataaagaag acagaaatga 51601 agagactttg aaaaatatag tgaaaaaaat atataatgtt cttaaaaaga ccgaagactt 51661 tattgctgaa caatatcctc aaataccaaa atttttgccg gaagatatat tctttattac 51721 gacccaggag ctggaggaca tgtatcccga gctttctccg aaggagagag aggatgcaat 51781 tgcaaaggag aaaaaagcga tatttctcat gaaaatagga ggtgttctca aatcagggaa 51841 gaaacatgac ggaagggcac cggattacga tgactggacg ttgaacgggg acataatttt 51901 gtggtatcct ttgctggaaa ggtcttttga gatatcttcc atgggaataa gagtggatga 51961 aaattcattg ctaagtcagc tgaaagaagc cggttgcgag gaaagaaaag aaatgaaatt 52021 ccacaaagat ttgcttcaag gaaagctccc ttacaccatt ggagggggta tcggacagtc 52081 gaggatttgc atgtattttc tgaagaaggc tcatatagga gaggttcaat cttcggtatg 52141 gccggattca atgattgaaa tttgcgaaaa tgcaaatatt aatttattat agattatgat 52201 tataattaaa gattatattt aatttttaaa gaatttatta aagattatat tattatatta 52261 ttgataaata gatgcattaa tttatggaaa aactaaaaca tgaattaaca aaaaggggtt 52321 aatgaaaaat gaaaactaca ctggtaaaaa gtctttatag aaatacaaaa gattatgtgg 52381 gaaaggaaat agttgttgcc ggttgggtac gcacggtcag agattcaaag gcttttggat 52441 ttattgaact gaatgacggt tcttttttta aaaatcttca aattgtgttc gaagaaaaga 52501 accttcccaa ttttaaagag atagcaaagc tttctgttgg ttcggcaatt attgcgcatg 52561 gggaattagt tgagactccc ggtgcaaagc agccttttga gttaaaggca accaagattg 52621 aaatagaagg agcgtccact cccgattatc ctctgcaaaa gaagaggcac tcttttgagt 52681 acttaaggac aattgcccat ttgagaccca gaacaaacac tttttcggca gtgttcaggg 52741 tcaggtccct tctggcatac gccatacata aatttttcca ggaaagaggg tttgtatatg 52801 ttcatacccc gattatcaca ggaagtgacg cggaaggggc aggacagatg ttcaaggtta 52861 caacccttga tataaacaac cctcccagaa aagaagacgg aacggtggat ttttcaaaag 52921 acttttttga cagggaaaca aatcttactg taagcggaca gcttgagggt gaaacataca 52981 gcatggcctt tagaaatata tacactttcg ggccgacttt cagagcggag aactccaata 53041 cggcaaggca tgcggcggaa ttttggatgg tggagccgga aatagccttt gccgatcttg 53101 aggatgacat ggaacttgca gaggacatgc tcaagtatat cataaattac tgcctggaaa 53161 atgctccgga ggaaatggag ttctttaaca attttattga caatacactg cttgatcggc 53221 tcaacaatat tgtaagttct gattttgccc atgttacata taccgaggcc attgatattt 53281 tgtcaaaagc cgatcaaaaa tttgagtatc ctgtaaagtg gggtaacgac ctgcagaccg 53341 aacatgaaag ataccttacg gaaaaggtgt ttaaaaagcc tgtgtttgtg actgactatc 53401 caaaagatat aaaagccttt tacatgaggc tgaatgacga taacaaaacc gttgcggcaa 53461 tggaccttct tgtgcccggt gtcggagaga taatcggagg aagccagagg gaagagagac 53521 tggattattt ggaaaacaga atgaaagagc ttggacttaa aatggaggat tactggtggt 53581 acttggatct tcgcaggtat ggaagcacca gacatgcagg cttcggactg ggatttgaaa 53641 gggctataat gtatatcacc ggcatgtcaa acataagaga tgtaatacct ttcccgagaa 53701 ctgtgcactc agcggaattt taacggaaat tccgttcaaa aagatgtaaa aaagaaaggg 53761 gcggtttttg tgatgcactt ttataaaaac cgtcccttgt gttttattgc atcttttatt 53821 gacatctttt tatttgtagc ttttttattc gtattttttt tagagctatg tttacatctt 53881 tttaaaattc gttttttatc tattacaaat attaggcttt tctattacgg ttcgtttccc 53941 gatacaagcc ttccggatat atagagggct atgtggtttg aatttccgta gtcattggcg 54001 gatgcagaga aggagtaatc gtttgcctgg ctgtaattgg accagtcatc ctttgaaaat 54061 cttgcctgca cttccacgct catgccgggc tctatgcttc ctgctccttc ggtaaagcct 54121 atttccaggt aatagtcggc attgtttttg ggagaggaaa gttttacaaa ttttccggtt 54181 acgttggagt ttcctgcaga gctccagtca caccagaatt gctgaccttt ttccccatca 54241 atggtgtaat agtatcttat cttgacatct gacagtttaa caggtgaacc ggagttgttg 54301 atgagtttaa accttggatt tatagtattt gtagtatctg aaccgttgcc gttggcatat 54361 tgcagtatta acctgcctac ggtgttatta cctgcgggtg atccggctgt tgtgttggac 54421 ggtctggctg gtgtattggg tgagttgggt gctgcgttgg atgaattata tggagtgttg 54481 gcgggattaa gcggtacgtt ggttggtgct gaggtgttct gcggtgatgg attttcatcc 54541 gggctgtttg tgtttgccgg actttctgtt attgttgcat cggaggttga caaactgtcc 54601 ggggtataat ccggtgtttc ggatttttga gtttcagagg atgaattgct gtcatcagag 54661 tttatacccg gtaccagtcc gtcttttttc tgctcaaaga aaatgtgata catggcgttt 54721 gccattgcca cttcggcctg tgcccagtaa cgatgatagg tcattaccgg atctttgccg 54781 ctttttatgg cttcttccac cattttataa tctttgtctt ctttgtattt tggacgaaga 54841 tctataaagg ttattccgtt ctttatttcg gcgccctggg cattgatgcc ggaaaaatca 54901 tgagggatgt aaacttcatc aaagaaacgt ttgtaatcag cccttggttc ctttgcggcc 54961 acaccctttt tatccctgta attgtgccac attctgtcga gaagctgttt ggctgtttca 55021 cgggctttgt catcaatttt cttttcatgt ttttccgtgg cggcggcata gtaaataagc 55081 gcttttgcat atgaagcggt tactcccacg tccactgtcc actctgtgac ggtacagtga 55141 aggtttttat tttcactggg ttttcctgtc catgggtcgg gctggccgga ccattccagg 55201 gtggaaggaa tctcgtaggt tccgtcactt tttaaacggg tgttttctat tgcccatgag 55261 acccattttt tgcagagttc cttaacccgg ctgtctcctg taagataata gtattccata 55321 atcctttcca ttgaccatgc ctgaaatcca aaccatctgt tgctcggtgg atcattgtaa 55381 acaggatgcg gatcataagc catatcgtag aatgtgcttg tgccttcagg atatttgccg 55441 tacgcacctg accagctgtt ggttacaccg ccggctatgg caccttcggc actttgaagg 55501 tacaaaaaca gttcaatctg acggtcaaga ctttgctccc aatccttttt agcgtttttg 55561 gattttggag tgaaaatgga ttcctttgcc aatgcgtagg cggccatcgg attttggtag 55621 ccctgatggc aatgggagct tccgattctc cagctccagg ttccgttgat atcgcctccc 55681 catgaggcat accaggataa aagataatgg cagctgtcat atcctgtgcc ggctcttccg 55741 ctgtcttgca ctcctatagg tctgaaatat ttgtcaaaga aagtatacct tagataatca 55801 cccatttttg ccgctttttc aaaatagggc tgaagttcct tttctttgcc ttgctctttg 55861 gaccaaaggt aagcccagta agttgcctga atctgtcttg catcggcatc ggaggctgag 55921 gtgtaacgcc actgccttac aggctcgccg aagtttccaa aaagttttag aaatcctccg 55981 ttgttgactt gtccccatct aaagtcttcc cacgaggggt ggggtattgt ttcccatacg 56041 gattcaccgg agcctctctg ataagtgttt atataagaac agcggcttgt accgtccccg 56101 tgatttccgt acccgtacca gttgtcaacg tccaggagcc agtgcatttg atatatggct 56161 tttgtaccgt aagttgaggc aagttcgtct gcaatgggat ctatgcctgt gggtgcattg 56221 atatcgcctg gtgttggata tttttcggga gagtcggctt ccggcgcata ttgggcaggc 56281 tgggtcggaa tgtatgaatt aacgccgggt tggtctcttt cgggatcggg tattatgtat 56341 tgttctgtct tgtcccatgc atctttaaaa tatgtccagt caccggtaag tttcccgtag 56401 gttgctccga gccagaccat gtagctcatg gcttcactgg tagtgagatg tccatagtcc 56461 ggagcttcca ccaaaagtgt ttctatggaa tggtacggaa ttccttcttc gctgagataa 56521 ccttgtttct ggatgtcttc aaaaagagct ataaacctgt cggaatagac tgattgaaca 56581 ttttctttgg aatatgtaac atttgaattg gatgattgtc tggaaggttt aaagctgttt 56641 ttgattgtga ttatcagagt tgaaacaacg ataacggcgg caattatgcc gcagcatgta 56701 ataatccttc ttcttcgcct taccttgtat cttaatttca tgatcctccc ctgataaacc 56761 tccttttata aacttttata aatatttacc tcatgtaatt attatactag gtaacttaaa 56821 ccattacaaa tatttctctt gcagaggcgg taagaattat ttttattttt aaaattaatt 56881 tttaaaactt ttttttgtgt tgtccgtata tatgatatga aacaaaagtg aattgatagt 56941 actgtcataa aggcgtttat gaagcataga ggaggagagg ttgatgaaaa acggtttggt 57001 ccgttcaaag tatgacaggg ttatatcagg tgtgtgtggg ggaataggag aatattttaa 57061 tattgaccct accattgtaa ggcttggttt tgttatagcg actgttttat ttagtggcct 57121 tgggctgttt gcgtatattg tggcaatttt tgtaataccc gaagctgaca gcgcagccaa 57181 tggctttact gattatgccc aaaaaggatt taacgattat tatgaccctg acaaggattt 57241 cagcaaagta ttggaagatg atgaggaata tataaaaaag gattctcatg gcggaaaaac 57301 ctttgttggc atttgtctca ttgtccttgg acttgtctcc ctgttaagag aacattttag 57361 ggaatatatt agcaaattta ttcacattga ttttaaaatt ttagtgtctt tgctgctgat 57421 agttgttgga gcgttgatta tattcagagg caggaggcgt ttgccatgaa aaagaataac 57481 agtggcatat tttttggact ttttataatt tttattggta tagtgctcat actatctcag 57541 tttggtatgc tggaccttga caaaatagtg aatttccttt cagatcatat atcaactata 57601 atctctttgc tgcttattgt gacgggagta aaccttgttt ttgacaagta taatggggtt 57661 aaattctttg cgtggacggc tttctttgca gtactgttaa tatccggctg catctatggt 57721 ggtgcaacgg aaaataagat tgagagaagc actgataagg cctatatcag accctttgct 57781 gaggaaaagc tgcccgaaac ggaggaaggg cggttaaaga tgaagctgag cggacaaaat 57841 ctgaaaattg gttccaccga gtccgggtta atcaagggag atatgacaga ttccggtgtt 57901 cagtacaaag tggattataa aaagaataat aaagttgctg atattgattt taaaatggag 57961 tcaggatttt ccctggagaa cgtcaaaaat cttgtttcca tgaatgggtc tgattcaaaa 58021 agttggacaa cggaagaacc gctggaggtt ttgctgaata cggatgtgct gtgggatata 58081 gacttgaagt ttggaggcac tgacggtgag atagatttat cgtctcttaa agtggaagag 58141 tttgagttgg acggtggtgc gggaaatatc aagcttatat tgggagacag acacccttca 58201 acaaaagttg atattgatgc cggggctgcc aattttaaaa tatttgtacc taagaactcg 58261 ggtatcaaag ttgaggttga tggactgctg agctctgtaa gtttcaaaga cttgaccctt 58321 gaacagacta aaaagaaaac ttatgtttcg ccggaatatg acaacgcaaa aaataaaata 58381 gagatcgata tagatattgg agcaggttct gttgagatta atgggattta gggttttggc 58441 ggttttttgg gtgtgatttg taccaaagac ggcttttgat gccggacttt ggtacttttg 58501 tgttaaggta ttttcaggac ctttctataa aagagattgc ctcaatagtg gatattcctg 58561 aaggtaccgt caagtcacta ctgagtaacg ggctgaaaga attgagaaaa ctgatgaaag 58621 acggcgtgag aggagatgag aatttatgaa ttgcgacaaa tttttagagt ttatggaaga 58681 gtatataatg ggggacttga tgagaattta agcggtatga tgaaaacaca ccttttggag 58741 tgtgaaaagt gtcggacgga gtatatagaa acaaagaaag ttattgaaaa tctttagata 58801 tatagaaaaa acggtgataa ttaatgagga cgttttaaac atgaataaaa agaatattgc 58861 aaaaaaagct gccggcaaaa aagataagcg gaattttaaa agctttattt ccgggattgc 58921 cgctgttgta ttctttctta tgtttctttt gacaggctca attgtggctt ttaccagttt 58981 ggcttcgaca tatttgcctg aggttccggt tgtaaagcag ctaaaagatg tgcaaaatga 59041 gtataatgcc attaagcggc agaatgaaga gatggcaaaa ctgaatgaga tattgaaaaa 59101 ggaaaatgag gaaattaaaa aggagaatga agaactgaag ataaggataa aggaaattgg 59161 tggggtttcc attccggaat accggaccag tgaaggtata aatgatgaat acaaccaaaa 59221 gattcaggag atagtgataa agtttatcag agccatgtac aggggggaca ttgagacggc 59281 caggaaaatt tccacagaag aatttaaaca ggaattagca caaaatgcca agcattatct 59341 tatgataaat aaaggagata ttttatttac ctgtataaca aatgttgcaa aaaaatggaa 59401 acttgtacgg ggtgtttgta aggcttaatg atactgtgga ccgagagctt ggtgattacc 59461 ggtggagttt tgaacttgta aagcatggtg acgaatttct tatttccttt gcagggaagg 59521 atgcataaaa ttgttgttat tttttgaaaa aacaaaattt aaacacgata aaaccaattt 59581 aataaatttt gctgtaaaga cagttgaaac cgtaaaaagt gtataaatgg taaaaagtta 59641 ctagtttttt cctttgaaat atagtataat aataactgtg gatacagttt caaataaaac 59701 tattatggtc taggaggtgc tctttcatgg gagtaatgga ttatcttagg aaaagaaaaa 59761 ttgaaaagaa aagagccgca agaaagaaag ccgtaaagaa cgcagcaata ggcgcaggat 59821 tgggagctgc tgttggtgtg acagcaggaa tattgttggc acctaaatca ggaaaagaaa 59881 caagagagga tattgccaga aatgccaaaa aggcaaccga agcagtatcc gaaaacacaa 59941 aaaaagccgt tgacaaggta tctgaaactt ccaaaaaggc tgtggataca attagaacaa 60001 ccataaatga agcaaaagcg aaaatagcgg aaagaaaagc cgccaaagcc aggaaagaag 60061 cggccgcaac cgaggaagtt gaggatggcg gcgagagcac tgaggttaaa gaataaaaat 60121 gaataaagtt tgaactttga aatatatttg aaatttaata caaagaaaaa a //