LOCUS NZ_ACVX01000028 53500 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00037, whole genome shotgun sequence. ACCESSION NZ_ACVX01000028 NZ_ACVX00000000 VERSION NZ_ACVX01000028.1 GI:256005332 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 53500) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 53500) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000028. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..53500 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene complement(<1..1016) /locus_tag="ClothDRAFT_2159" CDS complement(<1..1016) /locus_tag="ClothDRAFT_2159" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: ent:Ent638_0318 outer membrane autotransporter" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430298.1" /db_xref="GI:256005333" /translation="MQKRVRVITFFIIAVLATTLLPNSGMYAKAELGEEKETLEIELG EVKVNNVDNEVEIDVNIVNTEIETGEDVFQENKEFGLESNILENEKSIDCVIGKNWTL EQDETITGNLYINNGTIDLNGHTLTVYKDVIHAGGTLYINGGKLNIEGDFRIQKKLVN EEGKVIYKESYGVLKMTNPNDHVLVMGDFVMQNYYQTKDSKVLSDGVLEIKGDFTQIA CGVTPSFYACENHKVILSGTKLQRITMEETYSRFNILELKNTSEEGVVFLTPISEWKL ESDQVVSGDVVVGVRTIDLNGYTLRIKGDLIHPQGTLFINGGKLIVEGDYRIQTKSVD EEGNV" sig_peptide complement(924..1016) /locus_tag="ClothDRAFT_2159" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.894) with cleavage site probability 0.699 at residue 31" gene 2146..2319 /locus_tag="ClothDRAFT_2160" CDS 2146..2319 /locus_tag="ClothDRAFT_2160" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430299.1" /db_xref="GI:256005334" /translation="MKIREGMIPTILGTVVTAAGLSLKPFSSRISWGITGFGLAHILL GAIDLIEHRKEYA" gene complement(2463..3452) /locus_tag="ClothDRAFT_2161" CDS complement(2463..3452) /locus_tag="ClothDRAFT_2161" /EC_number="1.4.1.16" /inference="protein motif:TFAM:TIGR01921" /note="TIGRFAM: diaminopimelate dehydrogenase; KEGG: cco:CCC13826_1251 diaminopimelate dehydrogenase" /codon_start=1 /transl_table=11 /product="diaminopimelate dehydrogenase" /protein_id="ZP_05430300.1" /db_xref="GI:256005335" /db_xref="InterPro:IPR010190" /translation="MEKIRIGIVGYGNLGKGAELGIRQNKDMELVGIFTRRNPNSIKP LTEGVKVYSVDSARDMADKIDVMLLCSGSRTDLPVQGPEFAAMFNIVDGFDTHNKIQE YFESVDAKAKESKKVAVIACGWDPGMFSLNRLFGEVILPEGKTYTFWGKGVSQGHSDA IRRVKGVVDAKQYTIPVESAIELVRKGENPELTTRQKHIRECFVVVEEGADKERIERE IKTMPDYFADYDTIVHFISLEELKEKHSGIPHGGFSIRTGRTGINNENKHTIEYSLKL DSNPDFTANTLLAYARAAYRLNKEGVFGAKTVFDIPPAYLSPKSAEELRRSLL" misc_feature complement(2466..3452) /locus_tag="ClothDRAFT_2161" /note="diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921" /db_xref="CDD:162603" gene complement(3663..4436) /locus_tag="ClothDRAFT_2162" CDS complement(3663..4436) /locus_tag="ClothDRAFT_2162" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430301.1" /db_xref="GI:256005336" /translation="MDKEYTCKAGVIKSETLTECPNEFLTPKGFNGPFVGKIPVVLAE PVIQVDVESVIQLEEPALEIKRVKKNLFITQCKLIDTGFDYECKGKRTGKLFLSGYVR KNIEYATADCINEGKGGVSGRIKHTTVKVPFKCVTKIKFDVPPVICETGPAKEIASFT DSIKGKDFCGQEIIGSDPCEMGFVHVECFNEKVFCELEEVKIFEDDILKDPKGLGCDG KEEFVFDKIIEKMVIFIRLKLLQKQQVNIPGKEISEQKK" gene complement(4572..5285) /locus_tag="ClothDRAFT_2163" CDS complement(4572..5285) /locus_tag="ClothDRAFT_2163" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430302.1" /db_xref="GI:256005337" /translation="MNPQRDCKEFKVETRTITEVQSEPIYPTGRCGPVLARIPVVISQ SKVHIDIESRVCFDHSVFDIYSHSRNIYLTQCKLLNMGNKRYGKIYLNGYVSENIAYA AYCMKGREYGNKKSTSADMLYKTLKVPFECVAKIEYCTSPVFKTSNGFIPVALPDKEN SPEDSYFSGERLFCELDEASICESNVERKKLFSRINAGEDSFDTLTEYLVLSITFTLL QWQQVRIPGYFPNNPHSQI" gene complement(5479..6126) /locus_tag="ClothDRAFT_2164" CDS complement(5479..6126) /locus_tag="ClothDRAFT_2164" /inference="protein motif:PFAM:PF02698" /note="PFAM: protein of unknown function DUF218; KEGG: ppr:PBPRB0680 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF218" /protein_id="ZP_05430303.1" /db_xref="GI:256005338" /db_xref="InterPro:IPR003848" /translation="MEKEKLVQILWDYLRMNHKLEKSDCIVVLGSHDTRVAKRGAEIF LEGFAPLIVFSGGYGKLTKHIWNTTEAEKFARIAMDMGVPETSILIEDKSSNTGENIL FVKDLINNKKIKVQKIIAVNKPYMERRTYAAFKKLWEDIDVIVTSPQMELTEYLAGYR SGEITEDEVINVMVGDLQRIKMYPEKGFQVHQDIPKEVWDAYLKLVEMGYTKHLC" misc_feature complement(5635..6057) /locus_tag="ClothDRAFT_2164" /note="YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259" /db_xref="CDD:99750" misc_feature complement(order(5638..5640,5740..5742,5749..5751, 5761..5763,5827..5829,5836..5838)) /locus_tag="ClothDRAFT_2164" /note="putative active site; other site" /db_xref="CDD:99750" gene complement(6162..7070) /locus_tag="ClothDRAFT_2165" CDS complement(6162..7070) /locus_tag="ClothDRAFT_2165" /inference="protein motif:TFAM:TIGR00064" /note="KEGG: gur:Gura_1096 signal recognition particle-docking protein FtsY; TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54 G- domain; GTP-binding signal recognition particle SRP54 helical bundle; SMART: AAA ATPase" /codon_start=1 /transl_table=11 /product="signal recognition particle-docking protein FtsY" /protein_id="ZP_05430304.1" /db_xref="GI:256005339" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /translation="MGFFDKLKEGLKKTKNTITERIDKVLVSFGKIDEELFEELEEIL ITSDVGIDTSMKIIENLKNRVKETKTTDPAKVKELLKEELAQILSQGESDLKLDTTPS VILVVGVNGVGKTTSIGKIANLLKSQGKKVILAAGDTFRAAAIDQLEIWANRVGVEII KQAEGSDPAAVIYDAIQAVKARKADVLICDTAGRLHTKKNLMEELKKVFRIVDRELPG VSREVLLVLDATTGQNAISQAKTFSEVTDVTGIVLTKLDGTAKGGIIIAVASELNIPV KLIGVGEQMDDLQRFNAREFVEALFS" misc_feature complement(6168..7070) /locus_tag="ClothDRAFT_2165" /note="signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416" /db_xref="CDD:182441" misc_feature complement(6819..7052) /locus_tag="ClothDRAFT_2165" /note="SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881" /db_xref="CDD:145830" misc_feature complement(6231..6767) /locus_tag="ClothDRAFT_2165" /note="The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115" /db_xref="CDD:48379" misc_feature complement(6726..6749) /locus_tag="ClothDRAFT_2165" /note="P loop; other site" /db_xref="CDD:48379" misc_feature complement(order(6297..6302,6309..6311,6492..6494, 6657..6659)) /locus_tag="ClothDRAFT_2165" /note="GTP binding site; other site" /db_xref="CDD:48379" gene complement(7049..10681) /locus_tag="ClothDRAFT_2166" CDS complement(7049..10681) /locus_tag="ClothDRAFT_2166" /inference="protein motif:TFAM:TIGR02168" /note="TIGRFAM: chromosome segregation protein SMC; PFAM: SMC domain protein; SMCs flexible hinge domain protein; KEGG: gur:Gura_1094 chromosome segregation protein SMC" /codon_start=1 /transl_table=11 /product="chromosome segregation protein SMC" /protein_id="ZP_05430305.1" /db_xref="GI:256005340" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /translation="MHLKRLEIQGFKSFADRIQLEFNSGITAVVGPNGSGKSNISDAI RWVLGEQSAKTLRGGKMEDVIFAGTEHRKPMGFAEVSLTFDNSDGVLPIDFSEVTVTR RVYRSGESEYMINKTPCRLKDIYELFLDTGIGKDGYSIIGQGRVDEILSSKSEDRRAI FEEASGIMKYKVRKQEAEKKLEMTRQNLLRINDIIAELENQLEPLREQSEVAKRYLGL RETLKVLEVNVYIENIARYKEKIKELEENYASVKDNIDSENKRLEEITSLNQRNLSIL KDMEGRLEAAKQEYYAIDGNLEKSNSEIRLNQEKINNLFSNIERLDGEIAEIDEKIKT ILEEEASKNSKIVYLQERYNEYSAKLEEAEKKLQAIIATLNENERHIENLKTEIMEML DIQSDKKTQINNIKNHIEGIKKRQANIDKEVYQLTLEKDKECMKKEELSESIYKTNEL IKNIKDLLQELTEKRKDLGIKLEEEKKKQNNVRSQIQIMTSRQKMLIDMERNLEGYNR TVRVILQACRESHEFGKGIHGALAQLFTVDKRYETAIEMALGGALQNIVTTSEEDAKR VIEYLKKNNLGRATFLPISSVKGKYLDDSILNQLKDHEGFVGVASDLIEYDEQYRGII LSLLGKVVVVESLDAGIRMARKFGYGFRIVSLDGDILSTTGSISGGSKEKRESGILSR NREISELGESIARLKEDDEAIEKNVEGLIRELEEITDKISFEERSLKDNELVKIRDES HLAQIEENIKRSLARIDMLKQEKEQLIRQEKDTCLELSKYEDELSEIERDIAEKKEVV ARYQEKNKEEQSVRDALHNDITDYRISVNSILESMEGVKETLERLVNEKNSLVKAMER KKAEKARNEQEIKALQEKNEGLDKLIKKYEEEKSGKTFEIDRITEEKKIREEESAGII DQITEINKNILLLQEEYSRIEVKKAKLESEMESIQNRMWDEYELTYTNALELKKDIGS MAQAQKRIAEIRNEIKELGPVNVAAIDEYIKTKERFEFMSAQKSDMEQAEKKLQKVIN EMMTIMKRQFMEKFKLINENFNLVFRELFDGGRAELILVDKENVLESGIEIEVQPPGK KLQNLMLLSGGERAFTAIALLFAILRLNPTPFCVLDEIEAALDDANVYKFAQYLKKYS NVTQFAVITHRKGTMEAADTLYGVTMQEHGVSKVVSLKMGGKKWVKNIKKFGWRISRT WVFLTN" misc_feature complement(7127..10675) /locus_tag="ClothDRAFT_2166" /note="chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168" /db_xref="CDD:162739" misc_feature complement(<10223..10675) /locus_tag="ClothDRAFT_2166" /note="Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278" /db_xref="CDD:73037" misc_feature complement(10568..10591) /locus_tag="ClothDRAFT_2166" /note="Walker A/P-loop; other site" /db_xref="CDD:73037" misc_feature complement(order(10253..10255,10565..10573,10577..10582)) /locus_tag="ClothDRAFT_2166" /note="ATP binding site; other site" /db_xref="CDD:73037" misc_feature complement(10253..10264) /locus_tag="ClothDRAFT_2166" /note="Q-loop/lid; other site" /db_xref="CDD:73037" misc_feature complement(8750..9109) /locus_tag="ClothDRAFT_2166" /note="SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470" /db_xref="CDD:148212" misc_feature complement(7145..>7435) /locus_tag="ClothDRAFT_2166" /note="Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278" /db_xref="CDD:73037" misc_feature complement(7367..7396) /locus_tag="ClothDRAFT_2166" /note="ABC transporter signature motif; other site" /db_xref="CDD:73037" misc_feature complement(7307..7324) /locus_tag="ClothDRAFT_2166" /note="Walker B; other site" /db_xref="CDD:73037" misc_feature complement(7289..7300) /locus_tag="ClothDRAFT_2166" /note="D-loop; other site" /db_xref="CDD:73037" misc_feature complement(7208..7228) /locus_tag="ClothDRAFT_2166" /note="H-loop/switch region; other site" /db_xref="CDD:73037" gene complement(10810..11832) /locus_tag="ClothDRAFT_2167" CDS complement(10810..11832) /locus_tag="ClothDRAFT_2167" /EC_number="1.1.1.262" /inference="protein motif:TFAM:TIGR00557" /note="KEGG: kpe:KPK_3432 putative 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA" /codon_start=1 /transl_table=11 /product="4-hydroxythreonine-4-phosphate dehydrogenase" /protein_id="ZP_05430306.1" /db_xref="GI:256005341" /db_xref="InterPro:IPR005255" /translation="MDKPIIGVPLGDIAGIGPEIVVKALKEESIYRFLTPVVIGSKDA ICQALEICGLDSRINVVDETLSKVVSDSSTINLVDTGNIGVAGIKMGQVQAQCGKAAF DYIKRTVELAMDGKIDAVATTPINKESLKMAGIDYIGHTEILAGLTGTKDPLTMFEVG NLRIFFLSRHVSLRQACDLVTKERVLDYIERCTRALKLLGISEGTMAVAGLNPHSGEN GLFGREEVDFVVPAIKEAILKGYRVEGPIGADSVFYLASKGKYNSVLSLYHDQGHIAA KTLDFERTISVTIGLPFLRTSVDHGTAFDIAGTGKASAVSMVEALLVAGKYARNYKVN YKNNIL" misc_feature complement(10837..11832) /locus_tag="ClothDRAFT_2167" /note="4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743" /db_xref="CDD:179641" misc_feature complement(10843..11832) /locus_tag="ClothDRAFT_2167" /note="Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873" /db_xref="CDD:186232" gene complement(12008..12268) /locus_tag="ClothDRAFT_2168" CDS complement(12008..12268) /locus_tag="ClothDRAFT_2168" /inference="protein motif:PFAM:PF04232" /note="PFAM: Stage V sporulation protein S; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="Stage V sporulation protein S" /protein_id="ZP_05430307.1" /db_xref="GI:256005342" /db_xref="InterPro:IPR007347" /translation="MEVLKVSAHSQPKLVAGALAAILRGKSTAEIQAVGAAAVNQAIK AIAITRGFVAPNGIDIVTVPAFSSVCIDGEERTAIKFLVEPR" misc_feature complement(12011..12268) /locus_tag="ClothDRAFT_2168" /note="Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005" /db_xref="CDD:154140" sig_peptide complement(12179..12268) /locus_tag="ClothDRAFT_2168" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.632) with cleavage site probability 0.631 at residue 30" gene complement(12427..13443) /locus_tag="ClothDRAFT_2169" CDS complement(12427..13443) /locus_tag="ClothDRAFT_2169" /inference="protein motif:PFAM:PF04055" /note="PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_3202 radical SAM domain protein" /codon_start=1 /transl_table=11 /product="Radical SAM domain protein" /protein_id="ZP_05430308.1" /db_xref="GI:256005343" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /translation="MASKHIVIPIFIPHKGCPFDCIYCNQKYISGQKDDMTEEKMISI IESHIDSACEDTYIEIGFYGGSFTGIEREEQYRYLETANRYIKEGKVKSIRLSTRPDY INEEILDYLEKYSVKTIELGVQSLDREVLEKSCRGHSVEDVYNASALIKKRGFVLGIQ TMIGLPGDSRKKALHTAEEVVKIKPDILRIYPTLVVRGTYLEKMYIKGEYTPLELEEA VELCAELLYIYKKNNINVIRIGLQPTESINEGGDVIAGPFHPAFRQLVESKMALSAIE KAIVEKNLSKKDTLVICTDKKEISNVIGQGRKNVEYLRKKYGFDKIIVREYNVGHEIY DIKY" misc_feature complement(12823..13425) /locus_tag="ClothDRAFT_2169" /note="Radical SAM; Region: Elp3; smart00729" /db_xref="CDD:128968" misc_feature complement(12829..13413) /locus_tag="ClothDRAFT_2169" /note="Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335" /db_xref="CDD:100105" misc_feature complement(order(12865..12870,12958..12960,13078..13080, 13147..13155,13231..13233,13249..13251,13255..13257, 13369..13377,13381..13383,13387..13389,13393..13395)) /locus_tag="ClothDRAFT_2169" /note="FeS/SAM binding site; other site" /db_xref="CDD:100105" gene complement(13664..14374) /locus_tag="ClothDRAFT_2170" CDS complement(13664..14374) /locus_tag="ClothDRAFT_2170" /EC_number="3.1.26.3" /inference="protein motif:TFAM:TIGR02191" /note="KEGG: nis:NIS_0215 ribonuclease III; TIGRFAM: ribonuclease III; PFAM: ribonuclease III; double-stranded RNA binding domain protein; SMART: ribonuclease III; double-stranded RNA binding domain protein" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="ZP_05430309.1" /db_xref="GI:256005344" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR001159" /db_xref="InterPro:IPR011907" /translation="MFDLESFMGMINELERVIDYCFEDKMKLVLALTHSSYANECRDE RITSNERLEFLGDTVLNMVVSEYIYKNCSYLAEGEMTKFRANVVCERTLAECAQNLSI GKYLLLGKGEENTGGRTRVSILSDAVEALIGAIYIDGGLESARTFILNQLEKTIEKSI QGTIFMDYKTQLQEIIQKTNEHKIAYEIIEEKGPDHSKVFVAQVKVDEKVVGVGEGRT KKEAEQMAAKSSLENINA" misc_feature complement(13667..14356) /locus_tag="ClothDRAFT_2170" /note="ribonuclease III; Reviewed; Region: rnc; PRK00102" /db_xref="CDD:178863" misc_feature complement(13892..14293) /locus_tag="ClothDRAFT_2170" /note="RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593" /db_xref="CDD:29697" misc_feature complement(order(13940..13942,13967..13969,14135..14137, 14165..14173,14177..14182,14189..14194,14201..14203, 14210..14215,14222..14227)) /locus_tag="ClothDRAFT_2170" /note="dimerization interface; other site" /db_xref="CDD:29697" misc_feature complement(order(13988..13990,13997..13999,14204..14206, 14216..14218,14225..14227)) /locus_tag="ClothDRAFT_2170" /note="active site" /db_xref="CDD:29697" misc_feature complement(order(13988..13990,13997..13999,14216..14218)) /locus_tag="ClothDRAFT_2170" /note="metal-binding site" /db_xref="CDD:29697" misc_feature complement(13673..13876) /locus_tag="ClothDRAFT_2170" /note="Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048" /db_xref="CDD:28930" misc_feature complement(order(13706..13708,13715..13726,13853..13858, 13874..13876)) /locus_tag="ClothDRAFT_2170" /note="dsRNA binding site; other site" /db_xref="CDD:28930" gene complement(14526..15761) /locus_tag="ClothDRAFT_2171" CDS complement(14526..15761) /locus_tag="ClothDRAFT_2171" /inference="protein motif:TFAM:TIGR03150" /note="TIGRFAM: 3-oxoacyl-[acyl-carrier-protein] synthase 2; PFAM: Beta-ketoacyl synthase; KEGG: gsu:GSU1605 3-oxoacyl-(acyl-carrier-protein) synthase II" /codon_start=1 /transl_table=11 /product="3-oxoacyl-(acyl-carrier-protein) synthase 2" /protein_id="ZP_05430310.1" /db_xref="GI:256005345" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR017568" /translation="MKRRVVVTGLGVVSALGTEIDEFWNAIKEGKCGITMVTKFDASN MPTKVAAEIKDFDPTKYIDKKEAKRMDPYCQYAMAASKMAVEMSGLDLDKVDKNKFGV IVGSGIGGITTFEEQFRVYIEKGPGRVSPFFIPMMISNMAAGQIAMQFGAKGFNECVV TACATSANAIGDAFKVIQRGDADVIITGGSEAPITPLSFAGFCSMKAMTTTEDPALAC RPFDAERNGFVMGEGAAILVLEELEHALKRGANILAEIVGYGVTNDAYHITAPAPEGE GAARCMKMAIDDAGIKPEDIDYINAHGTSTEYNDKFETAAIKTVFGEHARKLAVSSTK SMTGHLLGAAGAIEAIITVLSIKDGFLPPTINYRTPDPECDLDYVPNKGRSADITYAL SNSLGFGGHNVTIVFKKFC" sig_peptide complement(15708..15761) /locus_tag="ClothDRAFT_2171" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.664) with cleavage site probability 0.646 at residue 18" misc_feature complement(14538..15755) /locus_tag="ClothDRAFT_2171" /note="beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150" /db_xref="CDD:163158" misc_feature complement(14541..15755) /locus_tag="ClothDRAFT_2171" /note="Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834" /db_xref="CDD:29421" misc_feature complement(order(14559..14561,14565..14567,14922..14924, 14964..14978,15147..15152,15159..15164,15225..15227, 15234..15239,15246..15248,15282..15290,15294..15296, 15300..15302,15318..15320,15330..15332,15342..15344, 15360..15362,15396..15401,15405..15407,15417..15422, 15441..15443)) /locus_tag="ClothDRAFT_2171" /note="dimer interface; other site" /db_xref="CDD:29421" misc_feature complement(order(14745..14747,14856..14858,15273..15275)) /locus_tag="ClothDRAFT_2171" /note="active site" /db_xref="CDD:29421" gene complement(15911..16135) /locus_tag="ClothDRAFT_2172" CDS complement(15911..16135) /locus_tag="ClothDRAFT_2172" /inference="protein motif:TFAM:TIGR00517" /note="TIGRFAM: acyl carrier protein; PFAM: phosphopantetheine-binding; KEGG: asu:Asuc_2000 acyl carrier protein" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="ZP_05430311.1" /db_xref="GI:256005346" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR006163" /translation="MFEKVRKIIAEQLGIEEDEITMESSFIDDLGADSLDIVELIMAL EEEFDLEIPDSEAEKITTVGDVVEYIKNNS" misc_feature complement(15917..16135) /locus_tag="ClothDRAFT_2172" /note="Phosphopantetheine attachment site; Region: PP-binding; cl09936" /db_xref="CDD:186876" gene complement(16223..16966) /locus_tag="ClothDRAFT_2173" CDS complement(16223..16966) /locus_tag="ClothDRAFT_2173" /inference="protein motif:TFAM:TIGR01830" /note="TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pca:Pcar_1438 3-oxoacyl-(acyl-carrier-protein) reductase" /codon_start=1 /transl_table=11 /product="3-oxoacyl-(acyl-carrier-protein) reductase" /protein_id="ZP_05430312.1" /db_xref="GI:256005347" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR002424" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR013968" /translation="MQLKGKTAIVTGSSRGLGKAIAWKLGNMGANIVLNGSPASTSLD ATAEEFKAAGINVVVAKGDVKNPEDVENMVKTAMDAFGRIDILVNNAGITRDTLMLKM SEKDWDDVLNTNLKSAYLCTKAVSKIMLKQKSGKIINITSIAGIIGNAGQANYAASKA GLIGFTKSIAKEFAAKGIYCNAVAPGIIKTDMTDVLPDKVKEMYLNNIPLKRFGTPEE VANVVGFLASDDSNYITGQVINIDGGLVM" misc_feature complement(16226..16966) /locus_tag="ClothDRAFT_2173" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature complement(16226..16966) /locus_tag="ClothDRAFT_2173" /note="3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557" /db_xref="CDD:180126" gene complement(17008..17943) /locus_tag="ClothDRAFT_2174" CDS complement(17008..17943) /locus_tag="ClothDRAFT_2174" /inference="protein motif:TFAM:TIGR00128" /note="TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: gur:Gura_1876 malonyl CoA-acyl carrier protein transacylase" /codon_start=1 /transl_table=11 /product="malonyl CoA-acyl carrier protein transacylase" /protein_id="ZP_05430313.1" /db_xref="GI:256005348" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /translation="MGKLAFLFPGQGAQYIGMGKQIADEYKSADAIFDEASEVLGFDM KKMIFEGDEETLKITENTQPAILTTSVALLQPVLEKGIKPDVVAGLSLGEYSAHVAAG TMTFRDAVALVRKRGKFMQEAVPVGVGTMAAIIGLDSEAVKECCKKASSEGIVEPANF NCPGQITVAGEVKAVEKALEIAKEMGAKRAMLLAVSAPFHCSMLKPAGDKLAAELERV TLGDMQIPVVTNVTAEYIIDKDKVKDLLIRQVSSSVLFEDSIRNMIEDGVDTFVEIGP GKVLSGFVKKINKEMKTLNVEDIESLNKTLQELGA" misc_feature complement(17026..17943) /locus_tag="ClothDRAFT_2174" /note="Acyl transferase domain; Region: Acyl_transf_1; cl08282" /db_xref="CDD:186816" misc_feature complement(17071..17937) /locus_tag="ClothDRAFT_2174" /note="malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128" /db_xref="CDD:161724" gene complement(17997..18992) /locus_tag="ClothDRAFT_2175" CDS complement(17997..18992) /locus_tag="ClothDRAFT_2175" /EC_number="2.3.1.41" /inference="protein motif:TFAM:TIGR00747" /note="KEGG: gme:Gmet_1599 3-oxoacyl-[acyl-carrier-protein] synthase III; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III" /codon_start=1 /transl_table=11 /product="3-oxoacyl-(acyl-carrier-protein) synthase III" /protein_id="ZP_05430314.1" /db_xref="GI:256005349" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /translation="MNKTCNCGILGLGSSFPEKVLTNHDLEKMVDTSDEWIIKRTGIS ERRVLDEDMPTYKLGVEAAKKALADAKVNPEEVDLIIVTTETPDYLSPSMSCLIQSEI GATRAAAFDLNAACSGFIYGLSVANQFIKSGFYKYVLLVGCEGLSKVVDWKDRNTCVL FGDGSGAALLGPVEEGYGIITTYTGADGEMGKNLTIPCCYIASRDIEARGGEAKRTLW MDGSEVFKFAVKIMEHATIKVLEDTGLSMDDIKVIMPHQANIRILEGAAKRLNIPNDK VFSNLHKYGNISSASIPVGLDEAYRQNLFSKGDNLILVGFGGGLTWGSAVIRWNK" misc_feature complement(18006..18977) /locus_tag="ClothDRAFT_2175" /note="3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352" /db_xref="CDD:181792" misc_feature complement(18012..18977) /locus_tag="ClothDRAFT_2175" /note="Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830" /db_xref="CDD:29417" misc_feature complement(order(18036..18038,18405..18410,18426..18443, 18549..18551,18606..18611,18618..18623,18630..18632, 18654..18674,18696..18698,18705..18707,18732..18734, 18738..18740)) /locus_tag="ClothDRAFT_2175" /note="dimer interface; other site" /db_xref="CDD:29417" misc_feature complement(order(18135..18137,18225..18227,18645..18647)) /locus_tag="ClothDRAFT_2175" /note="active site" /db_xref="CDD:29417" misc_feature complement(18216..18218) /locus_tag="ClothDRAFT_2175" /note="CoA binding pocket; other site" /db_xref="CDD:29417" gene complement(18976..19995) /locus_tag="ClothDRAFT_2176" CDS complement(18976..19995) /locus_tag="ClothDRAFT_2176" /inference="protein motif:TFAM:TIGR00182" /note="TIGRFAM: fatty acid/phospholipid synthesis protein PlsX; PFAM: fatty acid synthesis plsX protein; KEGG: gme:Gmet_1598 putative glycerol-3-phosphate acyltransferase PlsX" /codon_start=1 /transl_table=11 /product="fatty acid/phospholipid synthesis protein PlsX" /protein_id="ZP_05430315.1" /db_xref="GI:256005350" /db_xref="InterPro:IPR003664" /translation="MIILVDAMGGDNAPEAIVNGCLDAVSEADGFEILLIGDEGKIRE ILNKRSYDTSRIKIHHASEVITVEDTPTKAIKTKKDSSMVVGFKLLKEKKGDIFLSCG NSGALMTGALFILGRIKGVDRPAIGAIVPTKAGKGLIIDAGLNTVCKPVNYQQFGIMG SIYMKEMLGIENPKVGLLNIGAEVGKGNETLKQAYSLLSESNINFVGNVEGNDVALGK VDVVVCDGFTGNVLLKFYEGAGSYFYNLIKGIMLKNLKTKMAALMLKKDMKVLKKIMD ADENGGAPILGVDGLVFKSHGSSNARTVKNVIIKASKFAETKALDKIRQEFVNMEVED IEQDL" misc_feature complement(19006..19995) /locus_tag="ClothDRAFT_2176" /note="Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390" /db_xref="CDD:185961" gene complement(20057..20605) /locus_tag="ClothDRAFT_2177" CDS complement(20057..20605) /locus_tag="ClothDRAFT_2177" /inference="protein motif:PFAM:PF08220" /note="PFAM: regulatory protein DeoR; KEGG: hhe:HH1338 hypothetical protein" /codon_start=1 /transl_table=11 /product="regulatory protein DeoR" /protein_id="ZP_05430316.1" /db_xref="GI:256005351" /db_xref="InterPro:IPR001034" /translation="MKKERQAILLEKLEQDPFLTDEELSEMLGVSVPTIRLDRLELGI PELRERIKNVAQKNYSKVKSLQVKDIVGELVDITLGKSGISILETNSKMVFEKTRIVQ GHYIYSLAESLAIAVIDAQVALVGVANIKYKVPVYAGSKLVAKAEVKKSKDNKFIVWV KITEKNVEVFRGKFILVSLEKI" misc_feature complement(20063..20602) /locus_tag="ClothDRAFT_2177" /note="fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424" /db_xref="CDD:179847" misc_feature complement(20423..20593) /locus_tag="ClothDRAFT_2177" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:185792" misc_feature complement(20075..20464) /locus_tag="ClothDRAFT_2177" /note="The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509" /db_xref="CDD:186045" gene complement(21244..21744) /locus_tag="ClothDRAFT_2178" CDS complement(21244..21744) /locus_tag="ClothDRAFT_2178" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430317.1" /db_xref="GI:256005352" /translation="MLDEKYLVLNDMTVDDEGNIYAVDFYSDEVLKFDPYKKEMTRFS SDEKFKRPHMIQYLPSGKLMIEDSVDSENATRVSKFDKYGKKLTEKKLSNMINMSLFQ YEDELDKTFDIAQSGYMNLQISVTDTKKNKIKGISNVDFLSEITEYGRGVCLFGVDKK KGGFTF" gene complement(21835..22275) /locus_tag="ClothDRAFT_2179" CDS complement(21835..22275) /locus_tag="ClothDRAFT_2179" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430318.1" /db_xref="GI:256005353" /translation="MRCANLEDYLKEAFDVRVKKTVISLAVLCIAAAVLFKIITIMQK DEERNTDINSQVTENNSIIINEKTEIKVNQKVNNDVTKNKVRHTLDKNKLKKDYSEST MEDVPEVALFATWGDKEEQLKYKKYQESPNTDVVWDIPSSFAVD" gene complement(22602..23219) /locus_tag="ClothDRAFT_2180" CDS complement(22602..23219) /locus_tag="ClothDRAFT_2180" /EC_number="2.7.8.5" /inference="protein motif:TFAM:TIGR00560" /note="KEGG: dvl:Dvul_1316 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="ZP_05430319.1" /db_xref="GI:256005354" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /translation="MNLPNKLTLSRIILVPVFMLLIIPIPEWIVNSNFLAFAHSQLEN VNFFIKNYGNYMAAVLFFIAASTDGLDGYIARKRKQVTNFGKFLDPIADKLLVTAALV ALVERGDLSSWAAIVIIAREFIITGLRLVAAGEGIVIAASKWGKIKTVTQIIAILTAL LRGYLVDVLLGFPIDKVLMLVAVIATVYSAYDYIVKNGHVISQTR" misc_feature complement(22617..23219) /locus_tag="ClothDRAFT_2180" /note="CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453" /db_xref="CDD:186005" gene complement(23203..24564) /locus_tag="ClothDRAFT_2181" CDS complement(23203..24564) /locus_tag="ClothDRAFT_2181" /inference="protein motif:TFAM:TIGR01125" /note="KEGG: gsu:GSU3205 MiaB-like tRNA modifying enzyme YliG; TIGRFAM: MiaB-like tRNA modifying enzyme YliG; RNA modification enzyme, MiaB family; PFAM: Protein of unknown function UPF0004 ; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB" /codon_start=1 /transl_table=11 /product="MiaB-like tRNA modifying enzyme YliG" /protein_id="ZP_05430320.1" /db_xref="GI:256005355" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR005840" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /translation="MKKKVGIISLGCPKNLVDSEIMLGLLKKNDFEITSDSEEANVII VNTCGFIESAKEESINTILEMANYKNKNCEMLIVAGCLAQRYKDEIIKEMPEVDAVVG VSGYDEIAKVIEEFYSKKNDKNDKEKAVFHKDTLSVEYLNNERLLSTNSGYAYLKISE GCDNRCTYCAIPYIRGPYRSRKMEDIISEAEFLAGKGVKEVILVAQDVTVYGKDLYGQ KKLVELVREVSGIEGIEWIRLLYTYPEEIDEELIKEIANNEKVVKYLDIPIQHASDKI LKLMGRRSTSEGIRNILDRLRAEVPDIVLRTSLIVGFPGEDEKDFKILYDFVRKYEFD RLGVFTYSREEGTPAYDLKPQIKKSVKESRRNDIMQLQKEIVQRKNESRLEKVYKTLV EGVSEDGIFYYGRTYAEAPDIDGSVYFTSAEPLKFGEFVNVKVLNIDDYDLIGEVINE SSK" misc_feature complement(23230..24555) /locus_tag="ClothDRAFT_2181" /note="MiaB-like tRNA modifying enzyme YliG, TIGR01125; Region: TIGR01125" /db_xref="CDD:162211" misc_feature complement(24259..24555) /locus_tag="ClothDRAFT_2181" /note="Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919" /db_xref="CDD:144496" misc_feature complement(23491..24099) /locus_tag="ClothDRAFT_2181" /note="Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335" /db_xref="CDD:100105" misc_feature complement(order(23542..23547,23635..23637,23761..23763, 23836..23844,23944..23949,23953..23955,24055..24063, 24067..24069,24073..24075,24079..24081)) /locus_tag="ClothDRAFT_2181" /note="FeS/SAM binding site; other site" /db_xref="CDD:100105" gene complement(24710..24961) /locus_tag="ClothDRAFT_2182" CDS complement(24710..24961) /locus_tag="ClothDRAFT_2182" /inference="similar to AA sequence:KEGG:TVAG_244940" /note="KEGG: viral A-type inclusion protein" /codon_start=1 /transl_table=11 /product="viral A-type inclusion protein" /protein_id="ZP_05430321.1" /db_xref="GI:256005356" /translation="MADYEKKLNQIKDNLDKAKNLRIRAEARLEQLNRQKEEILSELK ELGVEPENLDNEIEKLKDEIESLIKKAESLLPEDLVARQ" misc_feature complement(24725..>24961) /locus_tag="ClothDRAFT_2182" /note="NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520" /db_xref="CDD:187089" gene complement(24961..26412) /locus_tag="ClothDRAFT_2183" CDS complement(24961..26412) /locus_tag="ClothDRAFT_2183" /inference="protein motif:PFAM:PF02463" /note="PFAM: SMC domain protein; KEGG: structural maintenance of chromosomes (SMC) family protein" /codon_start=1 /transl_table=11 /product="SMC domain protein" /protein_id="ZP_05430322.1" /db_xref="GI:256005357" /db_xref="InterPro:IPR003395" /translation="MITIKRIRIENFQSHKDTELSFSDGLNVIVGPSDQGKSAIIRAI KWVLYNEPRGTDFIRQGTNSARVTLELSNGYVITRERAPNKNRYTLKDPDGNVSVFEG FGNEVPLEIVKAHGIPKVALDMDVRASLNIGEQLEGPFLLSESGATRAKAIGRLTGLH IIDQAIKDCATDIRRENQTCDRIEREIEDIDKKLEEYKNIEELGRRLEESEKVIARME ALTAKVDMLEEKKNSLKDIETEYLAQTKILSRLDRLEECGVYLKSAEACFFKLNQILG IKKRYSEVLTGMEEMEKVLQKTSFVDEAVEILKKASDIFSKYEKLDRLRSEFSNVGRE VNQTKNILDRTSNVKELDFMIKNISDKVLLGSEITQLREKLVCLEREISRVKKNISSY ENINLVQEIVTSVDKKLEVLNKLEAAKKEYSAVCTSLNDGLEFMDKNKKEIQENLNIY IDILRKSGVCPLCKSSIGDEKLENIIRHYEEVH" misc_feature complement(<24970..26403) /locus_tag="ClothDRAFT_2183" /note="chromosome segregation protein; Provisional; Region: PRK01156" /db_xref="CDD:100796" misc_feature complement(<26194..26403) /locus_tag="ClothDRAFT_2183" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" misc_feature complement(26299..26322) /locus_tag="ClothDRAFT_2183" /note="Walker A/P-loop; other site" /db_xref="CDD:72971" misc_feature complement(order(26296..26304,26308..26313)) /locus_tag="ClothDRAFT_2183" /note="ATP binding site; other site" /db_xref="CDD:72971" gene complement(26409..27434) /locus_tag="ClothDRAFT_2184" CDS complement(26409..27434) /locus_tag="ClothDRAFT_2184" /inference="protein motif:PFAM:PF00149" /note="PFAM: metallophosphoesterase" /codon_start=1 /transl_table=11 /product="metallophosphoesterase" /protein_id="ZP_05430323.1" /db_xref="GI:256005358" /db_xref="InterPro:IPR004843" /translation="MCQKAPERECSNEVSFFTDSHIRGTTPKNRKDNFYETLKNKFYE IGDISGRYNVDYILHGGDWFERPDISPSIVREFAVIIKSFGKPIYTVAGNHDIYGHNP ATVGRTMLGLLEGTGIINLLVYDDEVILKKDGITVQLTGRSYNYEIDGENFRNYYIVK KRADVDYAINIVHGMLLLKPFYEGIRYTLLDDIKETEADITFAGHYHSGFGVRKINSK YFINPGSIVRISSSLTELERKPEVVYLEFNENGIHIEEIELKTARPGDEVLDREKLEA AKDRNLKLHQFYQGIEASGRYKKIDISQIVEEIASSDELSREVKEEALRRIGIARENL AKGQDEE" misc_feature complement(26745..27383) /locus_tag="ClothDRAFT_2184" /note="Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840" /db_xref="CDD:163616" misc_feature complement(order(26814..26822,26916..26918,27150..27155, 27249..27251,27372..27374,27378..27380)) /locus_tag="ClothDRAFT_2184" /note="active site" /db_xref="CDD:163616" misc_feature complement(order(26814..26816,26820..26822,26916..26918, 27153..27155,27249..27251,27372..27374,27378..27380)) /locus_tag="ClothDRAFT_2184" /note="metal-binding site" /db_xref="CDD:163616" misc_feature complement(order(26997..27002,27135..27140,27144..27146, 27240..27242,27348..27368)) /locus_tag="ClothDRAFT_2184" /note="DNA binding site" /db_xref="CDD:163616" gene complement(27476..28177) /locus_tag="ClothDRAFT_2185" CDS complement(27476..28177) /locus_tag="ClothDRAFT_2185" /inference="protein motif:PFAM:PF00300" /note="PFAM: Phosphoglycerate mutase; KEGG: bch:Bcen2424_0685 phosphoglycerate mutase" /codon_start=1 /transl_table=11 /product="Phosphoglycerate mutase" /protein_id="ZP_05430324.1" /db_xref="GI:256005359" /db_xref="InterPro:IPR013078" /translation="MAIKTRIIFVRHAEAEGNLNRVFHGWTDSSITERGHLQAQRVAQ RLKDVDIDVIYSSSLKRTLQTAQYIADVKNLPIIRTDKLKEINGGDWENREWEELPKL WPEEYDSWENRPHEHKMPGGESMVEFQKRLIDEVKYIIDNNKGKNICIVTHGTAIRSM MCYFKNCDLTEMINIQWYDNTSVTILDYEDGKFNIVLEGDTSHLEKELCTVQNQEWWQ EYNKKYEERIKKESM" misc_feature complement(27578..28162) /locus_tag="ClothDRAFT_2185" /note="Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067" /db_xref="CDD:132718" misc_feature complement(order(27716..27721,27995..27997,28142..28147)) /locus_tag="ClothDRAFT_2185" /note="catalytic core; other site" /db_xref="CDD:132718" gene complement(28266..29189) /locus_tag="ClothDRAFT_2186" CDS complement(28266..29189) /locus_tag="ClothDRAFT_2186" /inference="protein motif:TFAM:TIGR01037" /note="TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; KEGG: sat:SYN_02850 dihydroorotate dehydrogenase, catalytic subunit" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase family protein" /protein_id="ZP_05430325.1" /db_xref="GI:256005360" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /translation="MTEKSIDLSVDIAGLRLSNPVIAASGTFGFGREFVDYVDLNKIG GISVKGLTLEKRQGNRPPRIAETPAGILNSVGLQNPGVRAFIENEIPFLRKYNTKIIA NIAGNTIEDYCKMAELLSDADIDAIELNVSCPNVKKGCVAFGNSPAGISEITSKVKKY CKKPLIVKLTPNVTDIKEIAVAAEAAGADALSLINTILGMAIDIHRKRPILANNVGGL SGPAVKPIAVRMVYEVCSVVKIPVIGMGGISSGEDAVEFMLAGASAVMVGTANFINPA ACIDVVEGIKNYLKMYNHGSVYEIIGKLQLN" misc_feature complement(28284..29168) /locus_tag="ClothDRAFT_2186" /note="dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037" /db_xref="CDD:130109" misc_feature complement(28278..29165) /locus_tag="ClothDRAFT_2186" /note="Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740" /db_xref="CDD:73402" misc_feature complement(order(28362..28367,28371..28373,28527..28529, 28956..28958,28992..28994,28998..29003,29019..29021, 29043..29045,29079..29081,29088..29093)) /locus_tag="ClothDRAFT_2186" /note="heterodimer interface; other site" /db_xref="CDD:73402" misc_feature complement(order(28383..28388,28449..28451,28530..28532, 28602..28610,28686..28688,28791..28793,28800..28802, 28971..28973,29040..29042)) /locus_tag="ClothDRAFT_2186" /note="active site" /db_xref="CDD:73402" misc_feature complement(order(28383..28388,28449..28451,28530..28532, 28605..28610,28686..28688,28800..28802,28971..28973, 29040..29042)) /locus_tag="ClothDRAFT_2186" /note="FMN binding site; other site" /db_xref="CDD:73402" misc_feature complement(order(28281..28283,28290..28292,28410..28415, 28422..28424,28503..28508,28512..28520,28527..28529, 28563..28571,28578..28598,28671..28673,28755..28757, 28983..28991)) /locus_tag="ClothDRAFT_2186" /note="homodimer interface; other site" /db_xref="CDD:73402" misc_feature complement(order(28602..28607,28794..28796,28800..28802, 28971..28973)) /locus_tag="ClothDRAFT_2186" /note="substrate binding site; other site" /db_xref="CDD:73402" gene complement(29182..29700) /locus_tag="ClothDRAFT_2187" CDS complement(29182..29700) /locus_tag="ClothDRAFT_2187" /inference="protein motif:PFAM:PF00175" /note="PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU1756 dihydroorotate dehydrogenase, electron transfer subunit, putative" /codon_start=1 /transl_table=11 /product="oxidoreductase FAD/NAD(P)-binding domain protein" /protein_id="ZP_05430326.1" /db_xref="GI:256005361" /db_xref="InterPro:IPR000951" /db_xref="InterPro:IPR001433" /translation="MDLIGPLGKPFHISRQYKRIAVVGGGIGIFPLLYLLREMKDADK SAFLGFRSSDYVVLTDEFEAASDRLSISTDDGSVGYKGIVTDLLEKDIAERGFDIIYT CGPMPMLRKVKDIAERAGIKCQVSLEQRMGCGIGACLVCACKTGKPDNWEYSHVCKDG PVFWSDEVILDD" misc_feature complement(29209..>29700) /locus_tag="ClothDRAFT_2187" /note="FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218" /db_xref="CDD:99814" misc_feature complement(order(29608..29610,29614..29625,29635..29637)) /locus_tag="ClothDRAFT_2187" /note="beta-alpha-beta structure motif; other site" /db_xref="CDD:99814" misc_feature complement(order(29386..29391,29548..29556,29617..29622)) /locus_tag="ClothDRAFT_2187" /note="NAD binding pocket; other site" /db_xref="CDD:99814" misc_feature complement(order(29230..29232,29278..29280,29287..29289, 29302..29304)) /locus_tag="ClothDRAFT_2187" /note="Iron coordination center; other site" /db_xref="CDD:99814" gene complement(29648..29968) /locus_tag="ClothDRAFT_2188" CDS complement(29648..29968) /locus_tag="ClothDRAFT_2188" /inference="protein motif:COG:COG0543" /note="KEGG: rma:Rmag_0233 dihydroorotate oxidase B, electron transfer subunit" /codon_start=1 /transl_table=11 /product="2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase-like protein" /protein_id="ZP_05430327.1" /db_xref="GI:256005362" /translation="MSRVLKERIESVEKIAKSIYKMTVKSEYISVNSRPGQFVNVKCC EGLNALLRRPISICSADVERGTFDIVFQVKGIGTEYLSQKKCGKRSGFDWSFGKTFSH IPAV" misc_feature complement(<29708..29944) /locus_tag="ClothDRAFT_2188" /note="Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868" /db_xref="CDD:157476" misc_feature complement(order(29729..29740,29753..29761,29801..29812, 29855..29857)) /locus_tag="ClothDRAFT_2188" /note="FAD binding pocket; other site" /db_xref="CDD:99778" misc_feature complement(order(29801..29806,29810..29812)) /locus_tag="ClothDRAFT_2188" /note="conserved FAD binding motif; other site" /db_xref="CDD:99778" misc_feature complement(order(29708..29710,29720..29722,29729..29731, 29738..29740)) /locus_tag="ClothDRAFT_2188" /note="phosphate binding motif; other site" /db_xref="CDD:99778" gene complement(29994..33212) /locus_tag="ClothDRAFT_2189" CDS complement(29994..33212) /locus_tag="ClothDRAFT_2189" /inference="protein motif:TFAM:TIGR01369" /note="TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: sfu:Sfum_0008 carbamoyl phosphate synthase large subunit" /codon_start=1 /transl_table=11 /product="carbamoyl-phosphate synthase, large subunit" /protein_id="ZP_05430328.1" /db_xref="GI:256005363" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR003806" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /translation="MPKRDDVKKVLVIGSGPIVIGQAAEFDYAGTQACRALKEENIEV VLVNSNPATIMTDTNIADRVYIEPLTVEVVKKIIIKEKPDSILPTLGGQTGLNLAMEL AESGFLKEHGVKLLGTATEAIKMAEDRQAFKDTMERIGEPCIASKVVNTVEDALDFAK EIAYPVVVRPAYTLGGTGGGIAYNEEELKEIASNGLRLSRVHQVLIEKCIAGWKEIEY EVMRDSKGNVITVCNMENIDPVGVHTGDSIVVAPSQTLTDREYQMLRSSALKIISALG IEGGCNVQFALNPNSFEYAVIEVNPRVSRSSALASKATGYPIAKVATKIAIGYGLDEI KNAVTGKTFACFEPTLDYVVIKIPKWPFDKFVKAKRTLGTQMKATGEVMAISSSFEGA LMKALRSLELGIFTLEQDIYKKFSAEEIRQKIKDVSDERILVIAEAIRRGVTVEEINN VTKIDLFFLNKIKNLVLMEEKLKTMKLSDFDEETLRTVKKMGFTDAVIAKYVGCDKKE VTAKRKELGICAVYKMVDTCAAEFEAMTPYYYSTYDECCEAKKSDKKKVLVIGSGPIR IGQGIEFDYCSVHSVWGLKQEGYETIIANNNPETVSTDFDTADRLYFEPLTPEDVENI VEKEKVDGAIVQFGGQTAIKLTKALVEMGVKVFGTEPKYIDAAEDREKFDRILEELGI PRPKGKTIFTLDEALEAANELGYPVLVRPSYVLGGQGMEIAYNDKDIVEFMEIINRVK QEHPILIDKYMMGKEIEVDAISDGEDILIPGIMEHLERAGVHSGDSISVYPTQTIGEK LKEKIVDYTQKLAKALRVVGLINIQYVYYNNELYVIEVNPRSSRTVPYISKVTGIPMV NIATRIMMGKKLKDFNYGTGLYKESEYVAVKVPVFSFEKLHDVDTSLGPEMKSTGEVL GIAKTFPEALYKGIIATGIKLPKKGGAILMTVRDTDKPELVQLAEEFEKLGFELYATG KTANMLNNQGIATNAVKKIGEGEPNLLNLIESGKISLIINTPTKGRQPERDGFKIRRK AVEMSIPCLTSLDTARAVLECIKLEKEEKDLEVIDLSVFDNQ" misc_feature complement(30012..33212) /locus_tag="ClothDRAFT_2189" /note="carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294" /db_xref="CDD:179998" misc_feature complement(32844..33191) /locus_tag="ClothDRAFT_2189" /note="Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289" /db_xref="CDD:144029" misc_feature complement(32211..32831) /locus_tag="ClothDRAFT_2189" /note="Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087" /db_xref="CDD:164032" misc_feature complement(31584..31955) /locus_tag="ClothDRAFT_2189" /note="Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787" /db_xref="CDD:145769" misc_feature complement(31221..31550) /locus_tag="ClothDRAFT_2189" /note="Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289" /db_xref="CDD:144029" misc_feature complement(30609..31208) /locus_tag="ClothDRAFT_2189" /note="Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087" /db_xref="CDD:164032" misc_feature complement(30063..30395) /locus_tag="ClothDRAFT_2189" /note="Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424" /db_xref="CDD:29636" misc_feature complement(order(30171..30179,30243..30245,30291..30296, 30300..30302,30360..30362,30378..30380)) /locus_tag="ClothDRAFT_2189" /note="IMP binding site; other site" /db_xref="CDD:29636" misc_feature complement(order(30210..30212,30246..30248,30252..30257, 30261..30263,30285..30287,30297..30299)) /locus_tag="ClothDRAFT_2189" /note="dimer interface; other site" /db_xref="CDD:29636" misc_feature complement(order(30072..30074,30084..30086,30099..30101)) /locus_tag="ClothDRAFT_2189" /note="interdomain contacts; other site" /db_xref="CDD:29636" misc_feature complement(30093..30101) /locus_tag="ClothDRAFT_2189" /note="partial ornithine binding site; other site" /db_xref="CDD:29636" gene complement(33303..34376) /locus_tag="ClothDRAFT_2190" CDS complement(33303..34376) /locus_tag="ClothDRAFT_2190" /inference="protein motif:TFAM:TIGR01368" /note="TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit" /codon_start=1 /transl_table=11 /product="carbamoyl-phosphate synthase, small subunit" /protein_id="ZP_05430329.1" /db_xref="GI:256005364" /db_xref="InterPro:IPR000991" /db_xref="InterPro:IPR001317" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006220" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR011702" /translation="MKAILALEDGTIFHGESFGAQGEVIGEIVFNTGMTGYQEVLTDP SYCGQIVAMTYPLIGNYGVNSEDIESEKPQVKGFIVRELCQNPSNWRAEETLNNYLKR NNIIGIEKIDTRALTRILREKGTMKGMISTDPNFNLDDKIDEIKAYVIKDPVMCVTTK EVLHYKGDGFKVALIDLGLKKNIVRSLLKRGCDVHVFPANSKAEDILAINPDGIMLSN GPGDPKDCVETIETIKKLMGKKPMFGICLGHQLTALANGADTEKLKYGHRGANHPVKD LEKDLTYITSQNHGYTIVESSMDKSRMTVSHRNMNDGTVEGVRYKDMPVFTVQFHPEA SPGPEDTAYLFDEFIDMMKKYSR" misc_feature complement(33321..34376) /locus_tag="ClothDRAFT_2190" /note="carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564" /db_xref="CDD:183597" misc_feature complement(33984..34376) /locus_tag="ClothDRAFT_2190" /note="Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988" /db_xref="CDD:144543" misc_feature complement(33330..33863) /locus_tag="ClothDRAFT_2190" /note="Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744" /db_xref="CDD:153215" misc_feature complement(order(33378..33380,33384..33386,33639..33641)) /locus_tag="ClothDRAFT_2190" /note="catalytic site; other site" /db_xref="CDD:153215" misc_feature complement(order(33357..33362,33366..33371,33447..33449, 33531..33533,33537..33539,33558..33560,33564..33566)) /locus_tag="ClothDRAFT_2190" /note="subunit interface; other site" /db_xref="CDD:153215" gene complement(34406..35350) /locus_tag="ClothDRAFT_2191" CDS complement(34406..35350) /locus_tag="ClothDRAFT_2191" /EC_number="4.1.1.23" /inference="protein motif:TFAM:TIGR02127" /note="KEGG: bqu:BQ10840 orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="ZP_05430330.1" /db_xref="GI:256005365" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011995" /translation="MFIDTLIEKIREKDNPSVVGLDPKIEYVPSFIKEDMYKKYGKNL KAVAEAILLFNKYIIDAVYDIVPAVKPQLAYYEMYGLEGMRVFYETCKYAKEKGLLVI ADGKRNDIGSTAQCYSAAYLGKTDIDEGISEAVFDVDALTVNPYLGVDGIKPFIDDCV KYNKGIFVLVKTSNKSSGEIQDILTQEGRSIYEIVAEYVESWGENKKGKYGYSCVGAV VGATYPNLAKILRKILKNSYILVPGYGAQGGTARDVAHCFNYDGLGAIVNASRSIMCA YKSEQWKNVYSEEKFYEASRAEAIRMRDDINSALRDRK" misc_feature complement(34520..35191) /locus_tag="ClothDRAFT_2191" /note="Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725" /db_xref="CDD:73387" misc_feature complement(order(34538..34543,34625..34627,34832..34837, 35033..35035,35039..35041,35135..35137,35141..35143)) /locus_tag="ClothDRAFT_2191" /note="active site" /db_xref="CDD:73387" misc_feature complement(order(34538..34540,34778..34780,34835..34837, 34880..34882,34913..34921,35000..35005,35012..35017, 35024..35029,35033..35038,35126..35131,35135..35137)) /locus_tag="ClothDRAFT_2191" /note="dimer interface; other site" /db_xref="CDD:73387" gene complement(35482..36768) /locus_tag="ClothDRAFT_2192" CDS complement(35482..36768) /locus_tag="ClothDRAFT_2192" /inference="protein motif:TFAM:TIGR00857" /note="TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: gur:Gura_1857 dihydroorotase, multifunctional complex type" /codon_start=1 /transl_table=11 /product="dihydroorotase, multifunctional complex type" /protein_id="ZP_05430331.1" /db_xref="GI:256005366" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /translation="MRVLIKGGHVVDPKTNTNGIMDILVEDGIITEIGKDIEISNGDI IYAEGKLVLPGLVDAHCHLRDPGFEYKEDIETGTMSAAMGGFTSIACMPNTDPVCDNK AVVKYIINKAKQDGYVNVYPIGAISKGQKGEELSEIGELKFAGAVAISDDGKPVKSSS LMKRALEYSSMFDIAVISHCEDLDLADGGVMNEGYWSTVMGLKGIPSAAEEIMVARDI ILSEYTKVPIHIAHVSTELSVELIRNAKKRGVKVTCETCPHYFVLTDEACKDFNTLAK VNPPLRTRRDVEAVIEGLKDGTIDIIATDHAPHHADEKNVEFNLAANGMVGFETALPL AITYLVKPGHLTISQLVEKMCVNPSKLLGINKGTLETGRSADITIVDLNEEFVVDVNK FKSKSKNSPFHGFKLNGSVYYTLVNGNVVVREKVLL" misc_feature complement(35497..36768) /locus_tag="ClothDRAFT_2192" /note="dihydroorotase; Validated; Region: pyrC; PRK09357" /db_xref="CDD:181796" misc_feature complement(<36580..36759) /locus_tag="ClothDRAFT_2192" /note="Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281" /db_xref="CDD:185881" misc_feature complement(35527..36648) /locus_tag="ClothDRAFT_2192" /note="Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317" /db_xref="CDD:30060" misc_feature complement(order(35854..35856,36073..36075,36232..36234, 36583..36585,36589..36591)) /locus_tag="ClothDRAFT_2192" /note="active site" /db_xref="CDD:30060" gene complement(36752..37690) /locus_tag="ClothDRAFT_2193" CDS complement(36752..37690) /locus_tag="ClothDRAFT_2193" /EC_number="2.1.3.2" /inference="protein motif:TFAM:TIGR00670" /note="KEGG: sat:SYN_01532 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="ZP_05430332.1" /db_xref="GI:256005367" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /translation="MILKSKDLLGLKDLTAEEIQYILNTAKTMKVILLSKNKKAPHLQ GKSIITLFYENSTRTRLSFELASKYLSANAANISVAASSVAKGETLIDTGKTIDMMGA DVIVIRHSMSGAPHLLARNVKASVINAGDGMNEHPTQALLDMFTIIEKKGSLKGLKVA IIGDIYHSRVARSNIWGMTKLGAEVSVAGPSTLMPPELDKTGVKVFTTVQEALIDADV VMGLRIQKERQKSGLFPSLREYSRFFGLDEKRLKLAKEDALILHPGPVNRGVELPSSV IDSERSFINEQVTNGVAVRMALLYLLTRRDSGESVN" misc_feature complement(36773..37648) /locus_tag="ClothDRAFT_2193" /note="aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856" /db_xref="CDD:179144" misc_feature complement(37241..37648) /locus_tag="ClothDRAFT_2193" /note="Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729" /db_xref="CDD:145728" misc_feature complement(36785..37228) /locus_tag="ClothDRAFT_2193" /note="Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185" /db_xref="CDD:143948" gene complement(37781..37924) /locus_tag="ClothDRAFT_2194" CDS complement(37781..37924) /locus_tag="ClothDRAFT_2194" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430333.1" /db_xref="GI:256005368" /translation="MKNCKDNYKDNINNQIKVQQKMCTIIPIFKYKTFIMCSEKNPVI FEK" gene complement(37970..38524) /locus_tag="ClothDRAFT_2195" CDS complement(37970..38524) /locus_tag="ClothDRAFT_2195" /inference="protein motif:PFAM:PF00156" /note="PFAM: phosphoribosyltransferase; KEGG: sat:SYN_03702 uracil phosphoribosyltransferase / pyrimidine operon regulatory protein" /codon_start=1 /transl_table=11 /product="phosphoribosyltransferase" /protein_id="ZP_05430334.1" /db_xref="GI:256005369" /db_xref="InterPro:IPR000836" /translation="MIDKAEIMDESAIMRAITRIAHEIIEKNKGVDNLALIGIQRRGV PLAKMIAEKIKGVEGKSVPVGILDITLYRDDLSMLSEHPIINGTQIDFPITDKKIVLV DDVLYTGRTVRAAIDALMDAGRPKMVQLAVLIDRGHRELPIRPDYVGKNVPTSRLEVV NVKLYEIDGVNCVTISDIEKGVRH" misc_feature complement(37994..38518) /locus_tag="ClothDRAFT_2195" /note="Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309" /db_xref="CDD:185893" gene complement(38823..39233) /locus_tag="ClothDRAFT_2196" CDS complement(38823..39233) /locus_tag="ClothDRAFT_2196" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: reu:Reut_A2359 major facilitator transporter" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430335.1" /db_xref="GI:256005370" /translation="MINKTGQAAKNILNGHSNIIMVIKGILVSYLFTIPMFAIFAYFL KFTDFPLKYMSTAVIITTLLSIVIAGWISTKNVKSKGWLNGAIVGFIYMLILYLVSSI VYREFAINSYVLILLGIGILSGSIGGILGINLKR" gene 39524..39997 /locus_tag="ClothDRAFT_2197" CDS 39524..39997 /locus_tag="ClothDRAFT_2197" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430336.1" /db_xref="GI:256005371" /translation="MGFFDFLFNTQSDTNTDNSNDPAENRAKKFQPFNQEFSLDMTTE PYGNNMDETNNFYSNNGVQIQDAKNVFRLVYSGILAKNNPENLYAVIGYGNNLAWEDI ESYSMRKIGDQKYELLFPVKRPGNINIAFKDDADNWDNNSGMNYCFENHVYQGSH" gene complement(40043..40342) /locus_tag="ClothDRAFT_2198" CDS complement(40043..40342) /locus_tag="ClothDRAFT_2198" /inference="protein motif:TFAM:TIGR00739" /note="TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: sil:SPO2322 preprotein translocase, YajC subunit" /codon_start=1 /transl_table=11 /product="preprotein translocase, YajC subunit" /protein_id="ZP_05430337.1" /db_xref="GI:256005372" /db_xref="InterPro:IPR003849" /translation="MPQEGGAGIQELISALIVPLAFIVIMYLMIILPQRKREKKHAEM LKALKTGDNIITTGGIIGKIINIKDDEITIETSVERTQIKIIRSAISRVVDSEES" misc_feature complement(40061..40312) /locus_tag="ClothDRAFT_2198" /note="Preprotein translocase subunit; Region: YajC; cl00806" /db_xref="CDD:186197" gene complement(40445..41569) /locus_tag="ClothDRAFT_2199" CDS complement(40445..41569) /locus_tag="ClothDRAFT_2199" /EC_number="2.4.2.29" /inference="protein motif:TFAM:TIGR00430" /note="KEGG: geo:Geob_3451 queuine tRNA-ribosyltransferase; TIGRFAM: queuine tRNA-ribosyltransferase; tRNA-guanine transglycosylase, various specificities; PFAM: Queuine/other tRNA-ribosyltransferase" /codon_start=1 /transl_table=11 /product="queuine tRNA-ribosyltransferase" /protein_id="ZP_05430338.1" /db_xref="GI:256005373" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /translation="MSAIRYELIKKCKQSGARLGRVYTPHGCFDTPAFMPVGTQATVK GMSPDEMKEIEAQIILSNTYHLHMRPGEDIVKEAGGLHGFMNWDRPILTDSGGFQVFS LSDLRDIKEEGVTFKSHIDGSKHFISPEMAIKIQNDLGADIIMAFDECIPYPADYDYA KKSLERTTRWAKRCKDAHRNPEKQALFGIVQGGMYKDLRQQSAYELLELDFPGYAIGG LSVGEPAEIMYEMLEVTVPLLPEDKPRYLMGVGSPDYLIEGAIRGIDMFDCVLPTRIG RNGTVLTSKGRIIVRDAIYARDYTPIDPECDCYACRNFTRAYIRHLLKSGEVLGIRLT TWHNLRFLINLMKKVRQAIMEDRLLDFRDEFFSKFGYKKI" misc_feature complement(40466..41566) /locus_tag="ClothDRAFT_2199" /note="Queuine tRNA-ribosyltransferase; Region: TGT; cl00409" /db_xref="CDD:185977" gene complement(41633..42658) /locus_tag="ClothDRAFT_2200" CDS complement(41633..42658) /locus_tag="ClothDRAFT_2200" /inference="protein motif:TFAM:TIGR00113" /note="TIGRFAM: S-adenosylmethionine/tRNA-ribosyltransferase-isomerase; PFAM: Queuosine biosynthesis protein; KEGG: gme:Gmet_0851 queuosine biosynthesis protein" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine/tRNA-ribosyltransferase- isomerase" /protein_id="ZP_05430339.1" /db_xref="GI:256005374" /db_xref="InterPro:IPR003699" /translation="MKVSDFYYDLPQELIAQEPVEKRDMSRLMVLDKETGKISHKRFK DIVEYINKGDCLVLNDTRVIPARLLGEKEGTGGKIEFVLLKRINGDVWEVILKPGKKA KPGARFVFGNGELKAEVIEIVEEGNRLVRFEYDGIFEEILDRIGIVPLPPYITKKLDD AERYQTVYSRYKGSAAAPTAGLHFTLELLEELAGRGVKIAYVTLHVGLGTFRPVKVEN LEEHKMHSEFYRIKEEDCDKINSTKQNGGKIIAVGTTSCRVLETVGDENGIVRPQSGW TDIFIYPGYKFKVVDSLITNFHLPESTLIMLVSALAGREKILEAYNIAVKERYRFFSF GDAMFIK" misc_feature complement(41639..42658) /locus_tag="ClothDRAFT_2200" /note="Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523" /db_xref="CDD:186057" misc_feature complement(41639..42658) /locus_tag="ClothDRAFT_2200" /note="S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147" /db_xref="CDD:178900" gene complement(42882..44594) /locus_tag="ClothDRAFT_2201" CDS complement(42882..44594) /locus_tag="ClothDRAFT_2201" /inference="protein motif:TFAM:TIGR02669" /note="TIGRFAM: SpoIID/LytB domain protein; PFAM: Stage II sporulation D domain protein; KEGG: gsu:GSU2621 stage II sporulation-related protein" /codon_start=1 /transl_table=11 /product="SpoIID/LytB domain protein" /protein_id="ZP_05430340.1" /db_xref="GI:256005375" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /translation="MVESLMSNCKSKTIMFRLILSLLIMYVSVLFSQSFIVYAYEGIP EKVRIGLMFNDPQTGQYSAVSSFTVDSKKGLQFGYFSEKGFTCLLKEPSGNAVTIRKD AFFVKGSDGFSEFNPSSGKVPSGEVIGAYHIKIGKDYKDYSALSKSLAEMKQKGVNAY AVYDDGWQIWTGFYVDEKEAKKAITNQIDPVLKIGDYSVVSPSESRIVVLSKDGQVML MFDSLYYAFQVHPEVSDETGVLRINGDDGKRYRGAFEILRLSGSDMTVINVINIEEYL YGVVPYEIQASSHPEALKAQAVAARTYTVKNLNKYKRLQFDLCPTVYSQVYKGFDGET AATNKAVDETKGKIVTYNGKPAEVFYFSSSGGRTEDVRNVWGSEGYPYLVSVEDKYES GDSWHYNWEVSFTAQQIKQIMTDRGIKIGDILGIYITKRSEAGRATEVIVKGSQGEKV YTNSSTRSFLNLDSQWYDITTDADIFVKGNDGEPVKTQLAGKKVMTASGLKTVSPANG KINVVTSSGLKTVSLIPTTYTFKGKGWGHAVGMSQEGAKGMANAGFTYEEILTHYFPG TKVE" sig_peptide complement(44475..44594) /locus_tag="ClothDRAFT_2201" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.963 at residue 40" misc_feature complement(42888..43802) /locus_tag="ClothDRAFT_2201" /note="SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669" /db_xref="CDD:162968" misc_feature complement(42885..>43796) /locus_tag="ClothDRAFT_2201" /note="Stage II sporulation protein; Region: SpoIID; cl07201" /db_xref="CDD:164094" gene 45332..46330 /locus_tag="ClothDRAFT_2202" CDS 45332..46330 /locus_tag="ClothDRAFT_2202" /EC_number="1.2.1.11" /inference="protein motif:TFAM:TIGR01296" /note="KEGG: dvl:Dvul_0328 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase dimerisation region; Semialdehyde dehydrogenase NAD - binding" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="ZP_05430341.1" /db_xref="GI:256005376" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012280" /translation="MKKVNLAVVGATGMVGRTFIKVLEERNLPIDNIYFFSSSRSAGS TVTFNNKEYVVEELTETSFDRGIDIALFSAGASVSEKFAPIAASKGCVVVDNSSCWRM NEKVPLVVPEVNPQDISCHQGIIANPNCSTIQAVVVLKPLHDKYKIKRIVYSTYQAVS GAGHNGYMDLENGLKGEPPKKFPHPIAGNCLPHIDSFLPNGYTKEEMKMVNETRKILG DYSIRITATTVRVPVFNGHSESINVEFEKQFDLEELKEVLRNAPGVVVQDDVANNVYP MPIYASGRDETFVGRIRRDESVESGVNLWVVADNIRKGAATNAVQIAEELIKMWNK" misc_feature 45338..46312 /locus_tag="ClothDRAFT_2202" /note="aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874" /db_xref="CDD:184874" misc_feature 45344..45685 /locus_tag="ClothDRAFT_2202" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature 45746..46270 /locus_tag="ClothDRAFT_2202" /note="Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774" /db_xref="CDD:145758" gene 46450..47328 /locus_tag="ClothDRAFT_2203" CDS 46450..47328 /locus_tag="ClothDRAFT_2203" /EC_number="4.2.1.52" /inference="protein motif:TFAM:TIGR00674" /note="KEGG: gbm:Gbem_4054 dihydrodipicolinate synthase; TIGRFAM: dihydrodipicolinate synthase; PFAM: dihydrodipicolinate synthetase" /codon_start=1 /transl_table=11 /product="dihydrodipicolinate synthase" /protein_id="ZP_05430342.1" /db_xref="GI:256005377" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /translation="MRKPIFTGAGVAIITPFTENGVNYDKLGELIEFQIREGIDSIII CGTTGEASTMPDEEHKAVIKYTVEKVNKRVPVIAGTGSNDTIHAVELSKYAEEVGADA ILSVTPYYNKTTQKGLYEHFKLIAESIKIPVVLYNVPGRTGLNIEPKTVKQLAEIENI VAIKECNINQVGEIISICPPDFTVYSGNDDMVVPLLALGGKGVISVMANIIPKKTHEL VATFLDGNVEESRKIQLSLLNLIKALFIEVSPIPVKAAMNLMGMEVGKCRLPLTDMTE KNFEILKQTLKDYGLI" misc_feature 46465..47307 /locus_tag="ClothDRAFT_2203" /note="Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis. It catalyzes the aldol condensation of L-aspartate-beta- semialdehyde and pyruvate to dihydropicolinic acid via a Schiff base formation between pyruvate and a lysine residue...; Region: DHDPS; cd00950" /db_xref="CDD:29943" misc_feature 46480..47316 /locus_tag="ClothDRAFT_2203" /note="dihydrodipicolinate synthase; Region: dapA; TIGR00674" /db_xref="CDD:129757" misc_feature order(46585..46599,46696..46698,46702..46704,46771..46779, 46864..46866,46870..46872,47194..47199,47251..47253, 47257..47259) /locus_tag="ClothDRAFT_2203" /note="dimer interface; other site" /db_xref="CDD:29943" misc_feature order(46588..46593,46855..46857,46870..46872,46939..46941, 47008..47010,47014..47016) /locus_tag="ClothDRAFT_2203" /note="active site" /db_xref="CDD:29943" misc_feature 46939..46941 /locus_tag="ClothDRAFT_2203" /note="catalytic residue; other site" /db_xref="CDD:29943" gene 47388..48146 /locus_tag="ClothDRAFT_2204" CDS 47388..48146 /locus_tag="ClothDRAFT_2204" /EC_number="1.3.1.26" /inference="protein motif:TFAM:TIGR00036" /note="KEGG: rbo:A1I_01615 dihydrodipicolinate reductase; TIGRFAM: dihydrodipicolinate reductase; PFAM: dihydrodipicolinate reductase" /codon_start=1 /transl_table=11 /product="dihydrodipicolinate reductase" /protein_id="ZP_05430343.1" /db_xref="GI:256005378" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR011770" /translation="MINILLSGCNGKMGQVISKLASEKENVRIAAGLDINTSIQNPYP VYTDINKCDVKVDVIVDFSHPSVLQNLLEFAIARKIPAVIATTGLSNSQVKMLHEASK NIPIFYSANMSIGVNLMLDLVKKAAKVLEGNFDIEIIEKHHNQKIDAPSGTALTIADA INSVLSEEHEYIYDRHSRRKKRNKKEIGIHAVRGGTIVGEHSVIFAGNDEIIEIKHTA TSKYIFAEGSLNAAVFLHDKQPGMYTMDDLIKNK" misc_feature 47388..48137 /locus_tag="ClothDRAFT_2204" /note="dihydrodipicolinate reductase; Provisional; Region: PRK00048" /db_xref="CDD:178822" misc_feature 47391..47723 /locus_tag="ClothDRAFT_2204" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature 47730..48134 /locus_tag="ClothDRAFT_2204" /note="Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173" /db_xref="CDD:147385" gene 48169..48627 /locus_tag="ClothDRAFT_2205" CDS 48169..48627 /locus_tag="ClothDRAFT_2205" /inference="protein motif:PFAM:PF01842" /note="PFAM: amino acid-binding ACT domain protein; KEGG: xau:Xaut_2625 aspartate kinase" /codon_start=1 /transl_table=11 /product="amino acid-binding ACT domain protein" /protein_id="ZP_05430344.1" /db_xref="GI:256005379" /db_xref="InterPro:IPR002912" /translation="MSQKVDANIDMSYDTALVTIRNVPNDIRLVSDIFTSIADENINI QMITKTPPNRGYVNILFCLPSEDLFTALAAINRCKDRAKDLLIEVDAYNTKVSLYRRE KKNFRNLVAELFRGFADEGIDIKFATSSESEISCLICEYDSDRAASLIKA" misc_feature <48169..48543 /locus_tag="ClothDRAFT_2205" /note="aspartate kinase; Reviewed; Region: PRK06635" /db_xref="CDD:180641" misc_feature 48214..48399 /locus_tag="ClothDRAFT_2205" /note="ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913" /db_xref="CDD:153185" misc_feature 48322..48327 /locus_tag="ClothDRAFT_2205" /note="putative allosteric regulatory site; other site" /db_xref="CDD:153185" gene complement(48714..49244) /locus_tag="ClothDRAFT_2206" CDS complement(48714..49244) /locus_tag="ClothDRAFT_2206" /inference="protein motif:PFAM:PF02572" /note="PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; KEGG: ppd:Ppro_0387 cob(I)alamin adenosyltransferase" /codon_start=1 /transl_table=11 /product="ATP:corrinoid adenosyltransferase BtuR/CobO/CobP" /protein_id="ZP_05430345.1" /db_xref="GI:256005380" /db_xref="InterPro:IPR003724" /translation="MEKGLIQVYTGDGKGKTTAAIGQGIRALGRGYTVYMVQFLKSQD TGELKVLEKLEPGFKIFRFEKKHGFIFNMDEKEIAELKNEVKTAFDFVKAVLQKEECD ILILDEIMAAINTGLIDVDDVADVLRNKPSGVEIILTGRDAPDKILELADYVSHNVCK KHPFERGIGARKGIEY" misc_feature complement(48753..49241) /locus_tag="ClothDRAFT_2206" /note="ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561" /db_xref="CDD:29983" misc_feature complement(order(48756..48758,48762..48767,48771..48794, 48798..48803,48840..48842,49095..49100,49104..49109, 49113..49115,49155..49172,49176..49181,49191..49193, 49203..49205,49236..49238)) /locus_tag="ClothDRAFT_2206" /note="homodimer interface; other site" /db_xref="CDD:29983" misc_feature complement(49194..49214) /locus_tag="ClothDRAFT_2206" /note="Walker A motif; other site" /db_xref="CDD:29983" misc_feature complement(order(48921..48923,49167..49169,49191..49199, 49203..49205)) /locus_tag="ClothDRAFT_2206" /note="ATP binding site; other site" /db_xref="CDD:29983" misc_feature complement(order(48753..48755,48822..48824,48900..48902, 48912..48914,49038..49040,49116..49118,49122..49124)) /locus_tag="ClothDRAFT_2206" /note="hydroxycobalamin binding site; other site" /db_xref="CDD:29983" misc_feature complement(48924..48938) /locus_tag="ClothDRAFT_2206" /note="Walker B motif; other site" /db_xref="CDD:29983" gene 49485..49919 /locus_tag="ClothDRAFT_2207" CDS 49485..49919 /locus_tag="ClothDRAFT_2207" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430346.1" /db_xref="GI:256005381" /translation="MKVFCIIIAIVLSLFNSPFTQVANAAGIKSTDNIKFKEITQMDF KDVHHIEIMNGTTGKFVIIKSSKLIEDIFAAFNNATYKIKTEDGNRGGWSYAVSFFTS GMNTPFYIDKNIKKMDTTPVLINGRTYIPVRYIAEAFNMKVN" sig_peptide 49485..49562 /locus_tag="ClothDRAFT_2207" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.954 at residue 26" misc_feature <49809..49916 /locus_tag="ClothDRAFT_2207" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" gene 50170..50252 /locus_tag="ClothDRAFT_R0037" /note="tRNA-Leu3" tRNA 50170..50252 /locus_tag="ClothDRAFT_R0037" /product="tRNA-Leu" gene complement(50821..52941) /locus_tag="ClothDRAFT_2208" CDS complement(50821..52941) /locus_tag="ClothDRAFT_2208" /inference="protein motif:PFAM:PF00580" /note="PFAM: UvrD/REP helicase; KEGG: bba:Bd3339 ATP-dependent DNA helicase" /codon_start=1 /transl_table=11 /product="UvrD/REP helicase" /protein_id="ZP_05430347.1" /db_xref="GI:256005382" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /translation="MNQEEFFRLLSDKYNINLNPQQKEAVLRIHGPSLLLSVPGGGKT TVIVSRCANMVLNHKIPPEKILTLTFSKAAAQDMKTRFCDIFGKELARNMVFSTIHSF CYSVVRCYVESKNKPMPQILEDGEGQISKNQMLKRIYHEVNNEYISDDRLEDLSNSVS FVKNMLYTEDDIKKLDIGIKNFIDIYNAYEKRKKSEGYIDYDDMLTGTYKLLKRNTGI TNMLRERYHYINVDESQDTSLVQHEIIKLVAHPKNNIFMVGDEDQSIYGFRAAFPQAL LDFKKTYPDAKILLMERNYRSTKSIVIPANIFIKQNKGRYEKNMYTENEEGEAVVFKH VKNRNEQYAYLTSVLKSESNLSECAVLYRNNISAIPLVDYLEYNNIPFYIRDTNLHFF KHWVVNDVLSFIRLALDPCDIEAFGQIYYKIGAFISREMFEYVAENMGKGKGVMETLL NFPNLPEDTCNAVKYLAGQIETIDYLKPLKAIEFIEKECEYEKYIRRASKEMGYSIDS LNYIIDGLKSIASRVDSFDEFFGRLSILKSAIENSGKNRYKNAVVLTTIHSSKGLEFD KVYMIDLVDGQFPSSKSISDCKEGNDALMEEEVRLFYVGVTRARKYLELITFSKVNNK PVSVSRFVHRFNLVQKQTESRALPNEICEGAILEHVKFGQGLVTRIDESKDLIVIEFE GVGTKMLSLKTCIDGKKIQPVKIS" misc_feature complement(51103..52890) /locus_tag="ClothDRAFT_2208" /note="Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210" /db_xref="CDD:30559" misc_feature complement(51694..52890) /locus_tag="ClothDRAFT_2208" /note="UvrD/REP helicase; Region: UvrD-helicase; cl14126" /db_xref="CDD:187234" misc_feature complement(50875..>51300) /locus_tag="ClothDRAFT_2208" /note="DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773" /db_xref="CDD:183307" gene 53142..>53500 /locus_tag="ClothDRAFT_2209" CDS 53142..>53500 /locus_tag="ClothDRAFT_2209" /inference="protein motif:PFAM:PF04199" /note="PFAM: cyclase family protein; KEGG: dal:Dalk_2911 cyclase family protein" /codon_start=1 /transl_table=11 /product="cyclase family protein" /protein_id="ZP_05430348.1" /db_xref="GI:256005383" /db_xref="InterPro:IPR007325" /translation="MKLIDLTHKIEDLLPEYPGDEETRLVNTRKLKTDGYTNHRLHID MHSGTHIDSPMHFVESKKYICDYPIESFIGEGCIIDARNEPVIKLKKEYKDIITDGCI LLLYTGLYRKFGTEEYF" misc_feature 53142..>53500 /locus_tag="ClothDRAFT_2209" /note="Putative cyclase; Region: Cyclase; cl00814" /db_xref="CDD:154016" ORIGIN 1 acattgccct cttcatccac tgattttgtt tggattctat aatccccctc aacaatcaat 61 tttcctccat tgatgaacag cgtaccctgt ggatgtatca ggtctccttt aattctcaat 121 gtgtagccat ttaaatctat tgtcctcacg cctacaacaa catctccgct aacaacctgg 181 tcactttcaa gtttccactc tgatattgga gttaagaaaa cgacaccttc ttctgatgtg 241 ttcttaagtt ccaaaatgtt aaatctacta taggtttctt ccatagtaat cctctgtaat 301 tttgttccgc ttaagataac tttgtgattt tcacaagcat aaaaggaagg tgtaactccg 361 catgctattt gcgtaaagtc accctttatc tccaatactc catccgatag aacttttgag 421 tctttggtct ggtaataatt ctgcattaca aagtcaccca ttaccagaac atggtcgtta 481 ggatttgtca tctttaaaac tccatagctt tctttatata taactttacc ttcttcattt 541 actaattttt tttgtattct gaagtctccc tcaatattaa gcttgccacc atttatgtac 601 aatgttcctc cagcatgtat aacatcttta tacactgtca gagtatgtcc gttaaggtct 661 attgttccgt tatttatgta cagatttcct gtaattgtct catcttgttc taatgtccaa 721 ttttttccaa taacgcaatc aatagatttt tcattctcca aaatattact ttctaatcca 781 aactctttat tctcctgaaa tacatcttcc ccagtctcga tctctgtgtt tactatattt 841 acatcaatct ctacttcatt atccacatta tttactttta cttccccaag ctcaatctcc 901 aatgtttctt tttcttcacc caactctgct tttgcataca ttcctgaatt gggtaataaa 961 gtagttgcca aaactgcaat aataaaaaaa gttatcactc gcactctttt ttgcattaca 1021 gatatctcct ttcatctttc ttgtaacata tcttactgtg cttttcttct tattcacttt 1081 tcaatacaat caacactcat gtataatccc tccttcaaat ttaaataaca actaaatcta 1141 actttataaa acagggctaa acacccttct aagccaattt aacatatata gttcttttgc 1201 tgtattatgt agatcaatgc atattattcc tcttagttaa aaaaataaca aaccgtgcag 1261 ttttaatata tactttgctt tatatggata ataaatttga ggggaaaatc tggatgggct 1321 cagatgtttt aattctacat ttgcaagcta tatttttcaa aagtttttga atattaacat 1381 aacattatta cataatcgct gtaaacttgt atggaagaaa aatcattaaa ccaatctttt 1441 tagataccgt gtatgcttaa acacttttta ttctgactta atcaacaacc caattagcaa 1501 agcttgtcca atcttccgta gaattcctca tgcggctttt ttcctgattt ttatcattct 1561 actaatgccg tattcaaagt agttggtaat tcttcttttc cgaataaact actgataagg 1621 acagataata attcacatcc ttttactagc ataaactgtt tctctgcatg taaaaaacca 1681 catgacaaac accttaaaac ctgattcccg ttactccacc ttctcacttt tccggtaata 1741 tcctttgttg tttctacttt cggccccgtc aggtttggtt tgtttaaaca tcctgaagtc 1801 caatgcatct tacaactaaa actgttcaag tatttcaagg ttaacttctt tatctttatt 1861 ttatatactg gacaatcttg tccattctat ttttactttc cgccgatgtt tttgtcaaca 1921 tatgaacttc attaatctca attggataat tttaaaatct atactattgg atttattttc 1981 taacaataaa actatttgtc atataatctt taacacatcg aaaaatcctt aactatagaa 2041 gtaaaaagta ataagtttct tctttccaat taattattcc caagcattaa aacaatcaaa 2101 ctacacaaac tactaacaaa ccaaacaact atggaggtca tttttatgaa aatccgtgaa 2161 ggaatgatac cgacaattct cggaactgta gttactgcag ccggattgtc actaaaaccg 2221 ttttcctcca gaatttcatg gggtataacc ggttttggcc tcgctcacat actcctcggg 2281 gcaattgacc ttatagaaca ccgcaaagaa tatgcttaaa acatataata tataccaaaa 2341 tataatatat aatagacagg gaaattccat ccccctgtct atcctttata ttcatatcca 2401 caacgtactt acaacaaaac gacaaacaac cgtcgcttat ataactgaca gatatcggag 2461 tattacaata aacttctcct gagttcttcg gcagatttgg gggaaagata tgccggagga 2521 atatcaaaga ccgttttagc accaaagact ccttccttgt ttaacctgta agcagctctg 2581 gcatatgcaa gcaaagtatt ggctgtaaaa tccggattgg agtcaagttt taaactatac 2641 tcaatagtat gtttgttttc attattgatg cctgttctac ccgttcttat tgaaaatccg 2701 ccgtgaggaa tcccgctgtg tttttctttc aactcctcca gcgaaataaa atgcacaatg 2761 gtgtcataat ccgcaaaata gtccggcatg gttttaattt ctctttcaat tctttcttta 2821 tccgcccctt cttccaccac tacaaagcac tctctgatgt gcttttgtct tgttgtaagt 2881 tcaggattct ctccctttct taccaattca atggcacttt caaccggaat ggtatactgt 2941 tttgcatcca ccacaccttt aactctcctg atggcatcgg aatgtccctg gcttacgccc 3001 ttgccccaga aagtataagt ttttccttca ggcaggataa cctctccaaa caggcggttt 3061 agcgagaaca ttcccgggtc ccagccacag gctatgacag caaccttctt tgactctttt 3121 gcttttgcgt ccacggattc gaaatattcc tggattttgt tatgagtatc aaatccgtct 3181 acaatattaa acattgcggc aaattccggt ccctgcaccg gcaaatccgt cctgcttccg 3241 ctgcagagaa gcataacatc tattttatct gccatatccc tggcactatc cacagaataa 3301 acttttaccc cttcagtcaa tggcttgatt gaattcggat ttcttcttgt aaaaatacct 3361 acaagttcca tatctttgtt ctgtcttatt cccaactcgg cacctttacc caaattgccg 3421 tatcccacaa tacctatcct tatcttttcc aaagtaactc ctcccattca tccaaacaag 3481 tatagaaaaa ctttgcgtta tgtattttat catattatag ccaattctac atctattaaa 3541 taaagatttt tatatatttt ttattgcaaa tataaactta aactattaaa ggaagccaaa 3601 cggcttcctg atttaatctt tggaaattct attcatcacg tacagaaatc tcttatgagc 3661 acttatttct tctgctcact tatttctttg cccggtatat taacctgctg cttttgcaaa 3721 agcttcaatc ttataaatat caccattttc tcaataattt tatcaaagac aaattcttct 3781 ttgccatcac atccaaggcc cttaggatct ttcaaaatat catcttcaaa tattttcact 3841 tcttcaagtt cacaaaacac tttttcattg aagcattcaa cgtgtacaaa acccatttca 3901 cagggatcgc tgccgataat ctcctgtccg caaaaatctt tgccttttat gctgtcagta 3961 aaggaagcta tttcttttgc aggacctgtt tcacaaatta ccggaggaac atcgaattta 4021 attttggtta cgcatttaaa cggcaccttt actgttgtat gctttattct accgcttact 4081 ccgccttttc cttcattaat gcagtcggca gtggcatatt caatattttt tcttacatag 4141 ccgctaagaa acagttttcc agttctcttt cctttacatt cataatcgaa tcccgtgtca 4201 atcagtttgc attgggtaat aaacaagttc tttttgaccc ttttgatttc aagggccggc 4261 tcttccagtt gaataaccga ctccacatcg acctgtataa cgggctcggc aagaactacg 4321 ggtatttttc caacgaaagg tccgttaaac cctttcggag tcaaaaattc gtttggacat 4381 tcagtaagag tttccgattt aattactccg gctttacaag tgtactcttt atccatcttg 4441 acacctccta aaacttagat aggtttaagt gatattttta tgtctcttac taataatata 4501 tgaaagagta cacttgggtg tgttatgtaa accatactgt ccctcgtgca aaattatgtt 4561 atgtaatagc tttatatctg actatgagga ttatttggaa aatatcccgg aattcttacc 4621 tgctgccatt gcaacagtgt aaaagttatt gacagtacca aatattccgt cagggtatca 4681 aatgaatctt ccccggcatt aatcctcgaa aatagttttt ttcgctccac attcgactca 4741 catattgacg cttcgtccaa ttcgcagaag agcctttccc cggaaaagta agaatcctcc 4801 ggactgtttt ccttatccgg caatgcaaca ggtataaatc cgtttgaagt tttaaacaca 4861 ggagaagtgc agtactcaat ttttgctaca cattcaaaag gcactttcaa agttttataa 4921 agcatgtcag ccgacgtact tttcttattt ccatattccc tgcctttcat gcagtatgcc 4981 gcatacgcaa tattttcact tacataacca ttcagataaa ttttgccgta ccttttattg 5041 cccatgttca acagcttaca ctgggtcaga tatatattcc ttgaatggct gtagatgtca 5101 aaaacagaat ggtcaaaaca aaccctggat tcaatgtcta tatgcacttt tgactgggaa 5161 ataacaacag gaattcttgc aagcacagga ccacaacgac cggtggggta aattggctca 5221 ctctgaacct ctgtaatggt cctcgtttca actttaaatt ctttacagtc acgctgagga 5281 ttcatagcta atgcctctat taaccaaaaa acaacagcta aatatccttt ttcataatat 5341 gagaagatag ctaatcttgt accggtccat aactttataa cacttcagag caaagaataa 5401 cacttcaaag caaagaaaat tttcgtttgc agtaaaattt tctcacatta caagtgttta 5461 cccgaggcag gagatatttt agcacaggtg cttagtgtat cccatctcaa caagcttcaa 5521 gtatgcatcc caaacctctt taggaatatc ctgatgcacc tggaagcctt tttcgggata 5581 catctttatt ctctgaaggt cgcctaccat tacatttatc acttcatcct ccgtaatctc 5641 cccgctccgg taacccgcaa gatactccgt aagctccatc tggggagagg taacaatcac 5701 gtctatatct tcccagagct ttttaaatgc ggcataggtc cttctttcca tataaggctt 5761 gttgaccgca ataatttttt gaacttttat tttcttatta tttattaaat cttttacaaa 5821 taaaatattt tcgcctgtgt ttgaagattt gtcctcaatc aaaatacttg tctccggaac 5881 tcccatatcc atcgctatcc gggcaaactt ttcagcctcc gtggtgttcc atatatgttt 5941 tgtaagcttg ccatatcctc ctgaaaagac aatcagagga gcaaaaccct ccaaaaagat 6001 ttctgctccc ctctttgcaa ctcttgtgtc atggcttccc aggacaacta tacaatcgga 6061 tttttcaagc ttatggttca tgcgaagata atcccataga atctgcacca gcttttcctt 6121 ttccatattc ttctccgtta aacccatata cttaatttac tttatgaaaa gagtgcttca 6181 acaaattccc tggcgttaaa cctctgaaga tcgtccattt gctctccgac accaataagc 6241 ttgacaggaa tattaagctc cgatgccacg gcaattatta taccgccttt ggcagttccg 6301 tcaagcttgg taagtacaat tccggtaaca tcagttacct cactgaaagt tttggcctgt 6361 gaaatggcat tctgacccgt agtggcatca agcacaagca atacttccct ggataccccc 6421 ggaagttccc ggtcgactat cctgaatacc tttttaagct cttccatcaa atttttcttt 6481 gtatggagtc ttcctgccgt gtcacagatt aacacatccg cctttcgagc ctttactgcc 6541 tgtatggcat cataaataac agccgcaggg tccgagccct ccgcttgctt tattatctca 6601 acaccaaccc tgttggccca tatttcaagc tggtctatag ccgcagccct aaaggtgtct 6661 cctgctgcaa ggatgacttt ttttccttgt gattttaaaa gatttgcaat tttacctatg 6721 gatgtagtct tacctacacc atttactcca accaccagta taacgcttgg tgttgtatca 6781 agttttaagt ccgactctcc ctggcttaga atttgggcaa gctcttcttt aagaagctcc 6841 tttaccttgg caggatccgt cgtttttgtt tcttttaccc tgtttttaag gttttcaata 6901 attttcatgc ttgtgtcaat tcccacgtcg gaagttataa gtatttcctc cagctcttca 6961 aaaagctctt cgtcaatttt cccgaaagat accaatactt tgtctattct ttcggtgatt 7021 gtgttttttg tctttttcag tccctctttt agtttgtcaa aaaaacccat gtcctgctta 7081 tcctccatcc aaatttcttt atatttttaa cccacttttt tccccccatt ttaagggaaa 7141 ccacttttga aacaccatgc tcctgcattg ttacaccata cagcgtatcg gcagcttcca 7201 tggtgccctt tctgtgagta ataaccgcaa actgagttac attggaatat ttctttaaat 7261 attgtgcaaa cttgtacaca tttgcatcat ccaaagctgc ttcaatctca tccagcacac 7321 agaagggcgt cggattaagc cttagaatgg caaaaagcag cgcaattgca gtaaacgctc 7381 tttctcctcc cgaaagaagc ataagattct gaagtttctt ccccggaggt tgtacttcta 7441 tctcaatgcc gctttcaagc acattctcct tgtctaccag aatcaattcc gcccttccgc 7501 cgtcaaacaa ctctctgaac accaagttaa aattttcatt tataagttta aatttctcca 7561 taaactggcg cttcattatg gtcatcattt catttattac tttctgaagc tttttctcag 7621 cctgttccat atcgcttttc tgtgccgaca taaactcaaa acgctctttt gtctttatat 7681 attcgtcaat ggcggccaca ttgacaggcc ccagttcctt tatctcattt cttatttcgg 7741 caatcctttt ttgcgcctgc gccatgcttc caatatcttt tttaagctca agtgcgttgg 7801 tataagtcaa ctcatactca tcccacattc tgttttgaat agactccatc tcagactcga 7861 gctttgcctt cttaacctca attctactgt attcctcctg aagcagcaat atatttttgt 7921 ttatttcggt tatctgatct ataatacccg cagactcttc ctcccggatt tttttctcct 7981 ccgtaatcct gtctatttca aaagtctttc cagatttctc ctcctcatac tttttaatta 8041 gtttatcaag accttcattt ttttcctgca aagctttaat ctcctgctcg tttctggctt 8101 tctcggcttt ttttctttcc attgccttta caagactgtt tttctcattt accagtctct 8161 ccaatgtttc ctttacgcct tccatgctct ccagaatgga gtttacagaa atcctgtagt 8221 cggtaatatc gttgtgcaat gcatctctta ccgactgctc ttctttgttc ttttcctggt 8281 accttgccac aacctctttt ttctctgcaa tatccctttc tatttcagac agttcatctt 8341 cgtattttga aagctccaga caagtatcct tttcctgtct tatgagctgc tctttctcct 8401 gctttagcat atcaattctt gcaaggcttc ttttgatatt ttcctcaatc tgggccaaat 8461 ggctctcgtc tcttattttt acaagttcat tgtctttaag gcttctttcc tcaaaggata 8521 ttttgtccgt aatctcttca agctctctga ttaatccctc aacatttttt tctattgctt 8581 catcgtcttc cttaagcctt gcaatgcttt ccccaagttc ggagatttcc cgatttctgc 8641 tcaaaattcc cgactctctt ttttccttgc ttcctccgga tatggaaccg gtggtgctta 8701 atatgtctcc gtccagggat actattctaa agccgtatcc aaactttctt gccatcctta 8761 ttccggcatc caggctctct accaccacta ccttgcccag aaggctcaaa attattcccc 8821 tgtactgctc gtcatattca ataaggtcgg atgcaacccc gacaaagcct tcatgatctt 8881 ttaactggtt taaaatgctg tcgtcaagat attttccttt tacagaggat atgggaagaa 8941 aagttgccct tcccaaattg tttttcttta aatattctat taccctcttg gcatcctcct 9001 cactggtggt gacaatattc tgcaaagctc cacccagcgc catttctatc gctgtctcat 9061 accttttgtc cactgtgaac agttgagcca gcgcaccatg aatgcccttt ccaaactcat 9121 gagactcacg gcacgcctgt aaaataaccc ttacagtccg gttatagcct tccaggtttc 9181 gctccatgtc tattaacatc ttttgtctcg aagtcattat ctgtatttga gacctgacgt 9241 tattctgctt tttcttttcc tcttcgagct ttataccaag gtcttttctt ttttcagtta 9301 attcctgaag caagtctttt atatttttta taagttcgtt tgtcttgtag atactctcgg 9361 acagctcctc ttttttcatg cactccttgt ctttttcaag agtcagctga tatacttctt 9421 tgtcaatatt ggcctgtctc tttttgatgc cttcgatgtg gttttttata ttgttgatct 9481 gcgtcttctt gtccgactga atgtcaagca tttccattat ctctgtcttt aagttttcaa 9541 tatgtctctc attctcattc agtgtggcaa taatggcctg aagctttttt tcagcctctt 9601 caagctttgc cgaatactca ttgtatctct cctgaagata gacgatttta ctattctttg 9661 aagcttcttc ctccaaaata gttttgattt tctcatcaat ctcggctatt tccccgtcaa 9721 ggcgttcaat atttgaaaac agattgttga ttttttcctg gtttagcctg atttcggaat 9781 tggatttttc aagattaccg tcaattgcat aatactcttg ttttgcagct tcaagccttc 9841 cttccatatc ttttaaaatg ctcaagttcc tctgattgag gcttgtaatt tcctccagcc 9901 tcttattttc actgtctatg ttatctttta ccgacgcata gttttcttcc aattccttta 9961 tcttttcctt gtatctggcg atattttcta tatatacatt tacttccagt acttttagag 10021 tctctctcaa gccaaggtac ctttttgcca cctcggactg ctctcttaaa ggctccagct 10081 ggttttcaag ctcagcaata atatcattta ttctaagcag attctgcctt gtcatttcaa 10141 gctttttttc cgcttcctgc tttcgtacct tatacttcat aatcccggag gcttcttcaa 10201 aaatagccct tctgtcttcg gactttgagc ttaagatttc atcaactctt ccttgtccga 10261 ttatggaata accgtctttg ccaattcccg tatcaaggaa caactcatat atatccttaa 10321 gacggcacgg ggttttgttt atcatatact cactttcccc ggagcgatac accctcctgg 10381 ttaccgtaac ctcactaaaa tcaatgggaa gcacgccgtc agaattgtca aaagtaaggg 10441 aaacttccgc aaatcccatg ggctttctgt gttcggtacc ggcaaatatt acatcttcca 10501 tctttccgcc tcttaaggtt ttggcacttt gttctcccag tacccacctt atcgcatcgg 10561 aaatgttgct tttaccgctt ccgttcggtc ccaccacagc agtaatgccg gaattaaatt 10621 caagctgtat cctgtcggca aaggatttaa agccttgaat ttcaagtctc ttcagatgca 10681 aataaaacac ctcggcaatt ttagaatgaa aacctcaatt tattcattaa ctattctaac 10741 ataatttttt atattatcaa cacagcaaat tatctcacat caatatttca ggtaaaacaa 10801 aggcatattt cacaaaatat tgtttttgta gttgacttta taatttcggg catattttcc 10861 ggcaacaagc aaagcctcta ccatgcttac ggcgctggct tttcccgtac cggcaatgtc 10921 aaaagccgta ccgtgatcca cagacgtcct taagaaagga agacctatgg taaccgaaat 10981 tgtcctttca aaatccaatg ttttggcggc aatatgcccc tggtcatgat aaagagaaag 11041 tactgagttg tattttccct tacttgcaag ataaaacacc gagtcagccc caatggggcc 11101 ctccacacga tagcctttta aaattgcttc ttttatggca ggcaccacaa agtcaacctc 11161 ctcacggcca aaaagtccat tctctccgct gtggggatta agcccggcca ccgccatcgt 11221 tccctcactg atacccaaaa gctttaatgc tcttgtgcat ctttcaatat agtccagcac 11281 tctttctttt gtgacaagat cacatgcctg tcttaaagaa acatgccgac ttaggaaaaa 11341 tatccttaag tttcccactt caaacatggt caaagggtcc ttggtgccgg taagccccgc 11401 taaaatttcc gtatgcccga tatagtctat tcccgccatt ttcaatgatt ctttgtttat 11461 gggggtagta gccacagcat ctatttttcc gtccatggca agttctacgg ttcgcttgat 11521 ataatcgaaa gccgcttttc cacattgtgc ctggacctgt cccattttta tgcctgccac 11581 accaatgttc cctgtgtcaa caagattaat cgtactgctg tcggatacaa ctttgctcaa 11641 agtctcatcc acaacgttta tacgactgtc aagcccgcaa atctccaatg cctgacagat 11701 tgcatccttt gagcctataa caaccggtgt gagaaatcgg taaatacttt cttcctttag 11761 tgcctttacc actatctccg gaccgatacc cgctatatct ccaaggggta ctcctattat 11821 cggcttatcc acttgagttt cctcctgttc tttctctgat attttccacg tgtttatgct 11881 tcaaattata ttcaggtctc aaaattttgc atctaaaact gctaattata ttttacctaa 11941 aaaaacacat taaaaaagct gttcttgtaa ccaagaacag cctcaaaaca gtaaatatgt 12001 aataaaatta tctaggttcg actaagaatt taatcgcagt cctctcctcc ccgtcgatac 12061 aaacagatga aaaagctgga actgtcacga tgtctatgcc gtttggcgct acaaaacctc 12121 ttgtaattgc tattgcttta atagcttgat ttaccgctgc tgcccccact gcttgaattt 12181 cagctgtcga tttacctcta agaattgctg ccaatgctcc agcgaccaac ttcggctgcg 12241 aatgagctga tacctttaat acttccatac acttttcctc ctcataaaat ttaacttata 12301 taatataaat taaattaatt aaaacaaatt taattctctc tttaaaatat atgacaaact 12361 atataagata atctctaacc taactttatt ttataataat ccatgataac aaacaatatc 12421 ataaaattaa tattttatat cataaatttc atgtcccaca ttatattctc tgacaattat 12481 tttatcaaag ccatactttt ttcgtaaata ttctacattt ttccttcctt ggcctataac 12541 atttgatatc tcttttttat cagtgcaaat tacaagggtg tcttttttcg acaaattttt 12601 ctccacaatc gccttttcaa tagcactaag tgccattttt gattccacca gctgcctgaa 12661 ggcaggatga aaaggccctg ctataacatc gccaccctcg tttatgctct cggtgggctg 12721 aagcccgatt cttatcacat ttatattgtt ctttttataa atataaagaa gctcggcaca 12781 aagttcaacg gcttcctcaa gctccaaagg ggtgtattca ccttttatat acatcttttc 12841 aagataggta ccccttacca ctaatgtggg ataaatcctt aaaatatcag gctttatttt 12901 aacaacttcc tctgcagtat gaagagcctt ctttctgctg tctcccggaa gccctatcat 12961 tgtttgtatc ccaagtacaa agcctctttt cttaataagg gccgaagcat tgtaaacatc 13021 ctcaacactg tgtcccctgc agcttttctc aagaacttcc ctgtcaagac tttgaacccc 13081 aagctctatt gtctttacgg aatatttttc gaggtaatca agaatttctt cgtttatata 13141 gtccggcctg gttgagagcc gtatgctttt gacctttccc tcttttatat acctgttggc 13201 cgtctcaaga tacctatatt gttcttctct ttctatacct gtaaagctgc ctccgtaaaa 13261 gcctatctca atgtacgtat cttcacaggc agaatcaata tgggactcga taatcgatat 13321 cattttttct tcggtcatgt catctttttg accgcttata tatttttgat tgcaatatat 13381 acagtcaaaa ggacatcctt tgtgaggaat aaaaattggt atgacaatat gcttagaagc 13441 cattgtttcc cctcttaatg taattgattt aattaaaacg gattaatttt tatcgcacaa 13501 attttaaagc aattactgca tttattctca tattaatcat taattttcat gttaatctta 13561 aattagaatc taattgtata tataattaac cttttaattt aacatggaat ttttaattca 13621 atatcaaaac tctaatttat tttcgaaaat cttcataaac actttacgca ttaatattct 13681 ccaaagacga ttttgcagcc atttgctcag cttctttctt ggtccggcct tcaccgacac 13741 ctaccacttt ttcatccact tttacctggg caacgaacac tttgctgtgg tcaggcccct 13801 tttcctcaat tatctcatac gcaatcttat gttcattggt cttttgaata atctcctgca 13861 gctgggtctt ataatccata aaaatagttc cctgaatgga tttttctatt gttttttcca 13921 gttggttcaa tatgaaagtc ctcgcacttt ccaaacctcc gtcaatgtat atagccccta 13981 ttaacgcttc aacggcatct gaaagtatgg aaaccctcgt ccttccaccg gtgttctcct 14041 cgccttttcc gagaagaagg tatttcccaa tacttaggtt ctgcgcacac tcagccaaag 14101 tacgttcgca taccacattg gctctaaact ttgtcatttc cccttcagcc agatatgaac 14161 agtttttata aatgtattcg cttacaacca tgtttaaaac ggtatctccc aaaaattcaa 14221 gcctttcatt gctggttatt ctttcatccc tgcattcatt ggcataggaa ctgtgagtga 14281 gagccagtac aagcttcatc ttgtcctcaa aacaataatc aataactctc tccagttcgt 14341 ttatcatgcc cataaaactt tccaaatcaa acattttgct cccatccttc aaaggcaata 14401 atatatattt cctgacggaa aaatatatta tcatatttca cagctttagg ggaacggaat 14461 aaaccgtccc ccttttataa acacaattac aatataatgc atttgtatta atataattgt 14521 aatttttaac agaacttttt aaatacgatg gttacattgt gcccaccaaa tcccaaagag 14581 tttgacaatg cataggttat gtcggcgctt cttcctttat tcggaacata atcaaggtca 14641 cattcagggt ccggtgtgcg gtaattgatt gtcggaggca agaatccatc ctttatcgaa 14701 aggacagtaa taatagcctc aattgcgccg gccgcaccca aaagatgccc tgtcattgat 14761 tttgtggagc ttacagccag cttccttgca tgttcgccaa acacggtttt tatcgctgca 14821 gtttcaaact tgtcgttgta ttcggtggat gttccatgtg cattaatata atcaatgtct 14881 tcaggtttta ttcctgcatc atctatagcc attttcatac atcttgccgc accttcgcct 14941 tccggtgccg gagcggtaat atgatatgcg tcgtttgtaa ctccgtatcc cacaatctcg 15001 gcaaggatgt ttgctcctct cttcagcgcg tgctccaatt cttccaacac aagaattgca 15061 gcaccttctc ccataacaaa tccgtttctt tcggcatcga acggtctgca ggccaaagca 15121 ggatcttccg ttgtggtcat ggctttcatc gagcagaaac cggcaaaaga caacggtgtt 15181 atgggagctt ccgatcctcc ggtaattata acatccgcgt ctcccctctg gataactttg 15241 aaagcatcac caatggcatt ggcggatgtt gcgcatgcag ttacaacaca ttcgttaaag 15301 cccttggctc caaactgcat ggcaatttgt cccgctgcca tgtttgaaat catcatgggg 15361 ataaagaacg gacttactct gccgggccct ttctcaatat agaccctgaa ctgttcttca 15421 aatgtcgtta ttcctcctat tcccgaacca acaatgactc caaatttatt tttatccacc 15481 ttgtcaaggt caagccctga catttccaca gccattttgg aagcagccat tgcatactgg 15541 caatatggat ccattctttt tgcttctttt ttatcaatat actttgtagg gtcaaaatct 15601 tttatctcag ctgcaacttt tgttggcatg tttgatgcat cgaacttcgt taccatagtt 15661 attccgcatt taccttcctt tatcgcgttc caaaactcgt caatctcagt tcccaatgca 15721 gatacaactc ccagacctgt aacaacaact cttctcttca ttgccaaacc tcctgtatta 15781 atacttacaa gtatataaga agttaatcat ctatctatga taaatcagca attgcttttc 15841 atattttacc tgaaatttag tttgccataa taagtttatc ataaaaaagt cccttttgca 15901 gggacttttt ttatgaatta tttttaatgt actcaacaac gtctcctacc gtcgtaatct 15961 tttcggcctc gctgtcagga atttcgagat cgaactcttc ttccagggcc attatcaatt 16021 caacaatatc caaagagtct gcaccaaggt catctataaa agatgattcc attgttatct 16081 catcttcctc aatacccaac tgctctgcaa taatctttct aactttttcg aacattataa 16141 ttcacctcct tccacagggg ggttgcttga ttcttagtgt aaactattga tttgaaccaa 16201 atagtgttac aataagatat tattacatta ccaatccgcc gtcaatattt attacctgac 16261 ctgttatata atttgaatcg tcagatgcaa ggaaaccgac aacatttgcc acttcttcag 16321 gcgtcccaaa ccttttaagc ggtatgttat tcaaatacat ttcctttact ttgtcaggta 16381 acacatcggt catgtcggtt tttattatac ccggcgccac ggcattacag taaatcccct 16441 ttgcggcaaa ttcctttgcg attgattttg taaaacctat taaaccagct tttgatgctg 16501 cataattggc ctgacccgca ttaccaataa tacccgcaat agaggtaata tttataattt 16561 taccgctttt ttgttttaac atgattttgg agacagcttt tgtacaaaga taggcacttt 16621 ttaagtttgt attcaaaaca tcgtcccaat ctttttcaga cattttcagc atgagcgtat 16681 ctctggttat gcctgcgtta tttacaagta tgtcaattct tccgaaagca tccattgccg 16741 ttttaaccat gttctcaaca tcttcagggt tttttacatc cccttttgca acaacaacgt 16801 ttatcccggc agctttaaat tcctccgcag tggcatcaag gctggttgaa gcaggtgaac 16861 cgttaagaac gatatttgct cccatatttc ccaatttcca cgcaatagcc ttccccaggc 16921 ctctgctcga gccggttaca atcgcagttt ttcccttcaa ttgcatacta ttcacctcgc 16981 tttgccgtta tgaatagatt tatactttca ggctccaagt tcctgcaatg ttttattgag 17041 agattcaata tcctcaacat taagagtttt catctctttg ttgatcttct tgacaaaacc 17101 gctgagtacc ttgccgggac ctatctcaac aaaagtatcc accccgtctt caatcatatt 17161 tcttattgaa tcttcaaaca gcaccgagct gcttacctgt cttatcagaa gatcttttac 17221 cttgtctttg tctataatat attcagcagt tacatttgtt accacaggaa tttgcatgtc 17281 tccaagggtt actctttcaa gttccgcggc aagcttatcc cccgcaggct ttagcatgct 17341 gcagtggaac ggggcgctca cggcaagaag cattgccctt tttgctccca tctcttttgc 17401 aatttccaaa gccttctcca ctgcctttac ctctcctgca acagttatct ggcccgggca 17461 gttaaagttc gccggctcca caattccttc cgacgaagcc tttttgcagc attcttttac 17521 cgcctcactg tcaagcccta ttatagcggc catggtaccc actccaaccg gcaccgcctc 17581 ttgcatgaat ttacctcttt ttctcactaa tgccacagca tccctgaaag tcattgtgcc 17641 tgccgcaaca tgggcagaat actctccaag gcttagtccg gccacaacat ccggctttat 17701 acctttctcc aaaacaggct ggagcaaagc cacgctggtt gtcaaaatgg cgggctgagt 17761 attctcggtt atcttgaggg tctcttcatc cccctcaaaa atcatttttt tcatgtcaaa 17821 acccaaaact tccgatgcct cgtcaaatat ggcatcagca gatttgtact catcggctat 17881 ttgtttaccc attccgatat attgtgctcc ctgtccgggg aacaaaaatg ccagctttcc 17941 cattcttcta cctccagtgt taaaaacaaa attttaaaac ttcattttag tatgatttat 18001 ttattccatc tgattacggc ggagccccag gtaaggcctc ctccaaaacc gactaaaatt 18061 aaattgtcac ctttggaaaa gagattttgt ctataagcct catccaatcc cacaggtatg 18121 gatgcggacg aaatattgcc gtatttgtga aggtttgaaa acaccttgtc atttggtatg 18181 ttaagcctct ttgccgcacc ttccaaaatt cttatattgg cctggtgagg catgataacc 18241 tttatatcat ccatggaaag tcctgtgtct tccaacactt ttatagttgc atgttccata 18301 atttttaccg caaatttgaa aacttcgctg ccgtccatcc acagcgttct tttggcttct 18361 cctcctcttg cctcaatatc gcgggacgca atatagcagc aaggtatggt aaggtttttt 18421 cccatttcac cgtccgctcc ggtataggtg gtaattattc catagccttc ctccaccggt 18481 ccgagcagag ccgcccctga gccgtccccg aaaagaacgc aggtattcct gtctttccag 18541 tcaactactt tcgaaagtcc ttcacatccc acaagtaaca catatttgta aaagcctgac 18601 ttaataaact gattggccac ggacaagcca taaatgaatc cggagcatgc agcattgaga 18661 tcaaaggcag ccgccctggt tgctccgatt tcactttgaa taagacagga catggaaggg 18721 gaaagataat cgggtgtctc tgtggttaca attatcaaat ccacttcttc cggatttact 18781 ttggcatcgg ccagagcctt tttggcagcc tccacgccca gtttgtatgt cggcatatcc 18841 tcatccaata ctcttctttc cgatattcct gttcttttta taatccattc atccgacgta 18901 tccaccattt tttccagatc gtgattggta agcacttttt ccggaaagct gctccccaac 18961 cccaaaattc cgcaattaca agtcttgttc aatatcctct acctccatat taacaaactc 19021 ttgccttatt ttgtccagtg ccttcgtttc tgcaaatttg cttgctttaa taattacgtt 19081 tttaacggtt cttgcgtttg aacttccgtg acttttaaat acaaggccgt caacacccaa 19141 tataggagcg cccccgtttt catctgcatc cataatcttt ttcaaaactt tcatatcttt 19201 ctttagcatg agagccgcca ttttcgtttt caaattttta agcatgatac cttttatcag 19261 gttatagaaa tatgaaccgg ctccttcgta gaatttaaga agcacatttc cggtaaaacc 19321 gtcgcacaca accacgtcaa ctttgcctaa tgccacatca tttccttcaa cgtttcccac 19381 aaaattgata tttgattccg aaagaagtga atacgcctgc tttaaggttt cattgccttt 19441 tcccacctcg gcccctatgt ttaaaaggcc aaccttcgga ttttcaatgc ccagcatctc 19501 tttcatataa attgaaccca taataccaaa ctgctgataa ttaacaggct tgcaaacggt 19561 attaagtcca gcatctataa taagaccttt tccggccttg gtgggcacta ttgcaccaat 19621 tgcaggtctg tcgacaccct ttatcctgcc gagtataaac agggcacctg tcattaatgc 19681 tccgctgttt ccgcaggata aaaatatatc tccctttttc tctttcaaaa gcttgaagcc 19741 tacaaccatg gaagaatcct tcttggtttt gattgccttt gtaggcgtat cttccactgt 19801 tataacttcc gaggcatgat gaattttgat ccgggatgta tcatagcttc ttttgttcaa 19861 tatttcccgg atttttccct catcacctat cagcagtatt tcaaaaccgt cagcctcgga 19921 aacagcatcc aaacatccgt tgacaatggc ctccggcgca ttgtctccac ccattgcatc 19981 aaccaatata atcaaaagta ttcactccta aactccgata gtctgtattt tttccttcac 20041 taagttacta cacatttcaa attttttcaa gggacaccaa aataaatttc cctctgaaaa 20101 cttcaacgtt tttctccgta atttttaccc aaactataaa tttattatcc tttgactttt 20161 ttacttcagc cttggccaca agcttgcttc cggcatacac cggaaccttg tattttatgt 20221 ttgccactcc gaccagggca acttgtgcat ctattaccgc aatggcaagg gattccgcca 20281 gggaatatat ataatgtccc tgaacgatcc tggttttttc aaaaaccatt tttgaattgg 20341 tttcaagtat tgaaatacca ctctttccca atgttatatc aaccagttct ccgactatat 20401 ctttaacttg aagagatttt actttgctat aatttttttg cgctacgttt tttattcttt 20461 ctctaagctc cggaataccc agttccagtc tgtcaagcct tatcgtaggt acacttacac 20521 ctaacatctc agacagctct tcatctgtaa gaaacgggtc ttgctcaagt ttttcaagaa 20581 gtatggcctg tctttccttc ttcatacatg acgacctgct catgtgttca cctcttttta 20641 ttccgggctg cgtcccgaag caatatgttt cttcttttcg ttacaattac catttgcaca 20701 tgttgcttaa tcatagttgc ttaatcatat atattatatt atcttttcca cataattatt 20761 acctggtact aatctctgat attaaaagta tataatatat ttatcatata tgcaacaatt 20821 tcctcaattt ttcgtaaaat atttaagata aaaagctaaa aacggataat cgaacatgag 20881 gcaggtgtaa aacacctgcc tcatgtttgg gcaatctttt ccgggttatc ttgtcactta 20941 accgttatat ttagcataat atttaatttt ttatgtttta gtaaaatttt taaaaagtat 21001 attttaatat tttaaaaccc tctaaattca tttgtagttg ataaatacat ccgtcattcc 21061 caagcttaat tgccatgttg actaaatttg ctgtatttgc cgacatcgtt ccgtccccag 21121 gttgtaattt aattgcttcc gatgtatcat tcacaggatc aacccttaaa acgtaatacc 21181 ttgtatcctt gcatatagat tcttcatctt tataatggct tctatcttca ggatattcac 21241 gaattagaaa gtaaacccac cctttttttt gtcaacacca aaaagacaaa ctcctctgcc 21301 atattctgtg atttctgaca gaaaatccac attacttata ccttttattt tatttttctt 21361 agtgtccgta acggatattt gtaaattcat ataaccgctt tgcgcaatat caaaagtttt 21421 atccaattca tcctcatatt gaaataaact catattaatc atatttgaca gcttcttttc 21481 agtcaatttc ttgccatact tatcaaattt acttaccctt gttgcatttt cactgtcaac 21541 gctatcttca atcattaact tgccactggg taaatattga atcatatgag gtcttttaaa 21601 cttttcatca gaactgaatc tggtcatctc ttttttataa ggatcaaact taagtacttc 21661 atcagagtag aagtcaacag cataaatatt tccctcatca tcaaccgtca tatcattcaa 21721 tacaagatat ttttcatcta acatcctatc atgcggaata acattgataa gtttattgtt 21781 tttgtatact ttaattttgc tgtttaatgt atctgcaaca tatataacac cgttttaatc 21841 tactgcaaaa cttgaaggta tatcccatac tacatcagta tttggggatt cctgatattt 21901 tttgtactta agttgttctt ctttatctcc ccatgtagca aaaagtgcaa cttcagggac 21961 atcttccatt gttgattcgg aataatcctt tttcaattta ttcttgtcaa gggtatgtct 22021 gactttgttt tttgtaacgt cattattaac cttttgatta acttttattt cggttttctc 22081 attaatgatt atgctattat tttccgtaac ctgggaatta atgtctgtat tgcgttcttc 22141 atccttttgc attatcgtta ttatcttaaa cagtacagct gcagcaatgc ataatacagc 22201 cagtgaaatt acagttttct ttactctcac atcaaaggcc tccttcagat aatcttccaa 22261 atttgcgcat ctcattccca ccttttgaaa atttcagtcg tttcatccat ccacaccctt 22321 aagcagataa accattcgca gcctaaattt ttctgcaata ttaaaacatg tacggccaac 22381 cttgaacagt cataaatgca tttttactcc gtcaaccaaa tggaaacaac actgcccgaa 22441 aatacatcta ttcagcaatt tattatataa aaattatata aaatatgata tttgctataa 22501 ataccatcca tgaaaataca tcatttttct tcttcatttc tggctcaaaa agccacaaaa 22561 aaagagccag agtatggttc tctgactctt ttttatttta cttaccttgt ctggctgata 22621 acatggccat ttttcacaat ataatcataa gcggaatata cagtggcaat aactgcaacc 22681 agcatcaaga ctttgtctat gggaaatccc agtaaaacat ccaccagata tccccttaaa 22741 agtgcggtca aaattgcaat aatctgggta actgtcttta tttttcccca tttgcttgcc 22801 gcgataacaa ttccttcacc ggcagccaca agtcttaatc ccgtaattat aaactctctt 22861 gcgattatta caatggcagc ccatgacgaa aggtcacctc tttccacaag agcgacaagt 22921 gccgccgtaa ccaaaagttt gtcggctatt gggtccaaaa actttccgaa attcgttacc 22981 tgttttcgct tccttgctat atatccgtcc agcccgtcag tgcttgcagc aataaaaaac 23041 agaacagctg ccatataatt gccatagttt tttataaaaa agtttacgtt ttcaagctgt 23101 gaatgggcaa aagccaaaaa attactgttt acaatccatt ccggaatcgg tattatcaac 23161 agcataaaaa ccggaaccaa aataattctt gataaggtta gtttatttgg aagattcatt 23221 tataacctct cctattaaat cataatcatc aatatttaat actttgacat ttacaaattc 23281 tccaaattta agaggctctg cactggtaaa gtaaactgaa ccgtcaatgt cgggagcttc 23341 agcataagtt cttccgtaat agaaaatacc gtcttcggac accccttcca ccaaagtttt 23401 atatactttt tccaatctgc tttcattttt tctttgcaca atttcctttt gaagttgcat 23461 tatatcattt cttcttgact cttttacgct ctttttgatt tgcggtttta aatcatacgc 23521 aggcgtgccc tcctccctgg aataagtaaa gacaccaagc ctgtcaaact catattttct 23581 gacaaaatca taaagtattt taaagtcttt ctcgtcctca ccgggaaaac caactatcag 23641 cgaagtccgc agaacaatat cgggaacttc ggctcttaat ctgtccaaaa tatttcttat 23701 tccttcactt gtacttcttc ttcccattaa ctttaatatc ttgtcacttg catgctgaat 23761 tggtatgtcc aaatacttta ccactttttc gttgtttgca atttctttaa taagctcttc 23821 gtcaatctct tccggatagg tgtacaaaag tcttatccat tctatccctt ctatgccgct 23881 tacttccctt accagctcca caagtttttt ctgcccgtaa agatcttttc cgtaaacagt 23941 aacatcctga gccacaagga taacttcctt tacccctttt cctgcgagga actcggcttc 24001 cgaaattata tcctccatct ttctgcttct gtaaggcccg cggatatagg gaatggcaca 24061 gtaagtgcag cgattgtcac aaccttcgga tattttcaaa taagcatatc cactgttggt 24121 ggacaacaaa cgctcgttgt tcagatattc cacgcttaaa gtgtccttat ggaacactgc 24181 tttttcttta tcatttttat cattcttctt actgtaaaac tcctcaataa cctttgcaat 24241 ttcgtcatat ccggaaacgc ctacaaccgc gtccacttcc ggcatttctt ttattatttc 24301 atccttgtat ctctgggcaa gacatcctgc aacaatcaac atctcacaat ttttattttt 24361 gtaattcgcc atttcaagaa tggtatttat ggactcttct tttgcagact caataaaacc 24421 gcacgtattt acaattataa cattggcttc ttcactgtcg gatgtgattt caaaatcatt 24481 tttcttaagc aaccccagca ttatttcact atcgacaagg tttttcggac agccaagcga 24541 aataataccc acctttttct tcaaaccata cacctcattg cagtttttat ttttatatca 24601 ctatcattat ttaccttcgt atagaaattg tcaattgttt tttatgccgc ttaaagttta 24661 aagaaaatct ttgattctct aaaaaataaa aaaattaagt gaggctcatt tattgcctcg 24721 ctacaaggtc ttcgggcagc aaactttccg cctttttgat aagactttct atttcatctt 24781 taagtttttc aatttcattg tccaggtttt caggctccac tccaagttct ttcagctccg 24841 aaagtatttc ctccttttgc ctgttaagct gctcaagtct tgcctctgcc cggattctca 24901 aatttttggc tttatccaaa ttatccttaa tttgattaag ctttttttca tagtcagcca 24961 tcagtgtacc tcctcataat gccttattat gttttcaagc ttttcatctc cgatactgct 25021 cttgcaaagc ggacacactc cgctttttct aagaatatcg atatatatgt taagattctc 25081 ctgtatttct tttttatttt tgtccataaa ctccaaaccg tcattcagac tggtacaaac 25141 agcactgtac tcctttttgg ctgcttccag tttgtttaac acttccagct ttttatcaac 25201 agaagtcaca atctcctgca ctaaatttat attttcgtaa gaggatatgt tctttttgac 25261 cctggatatc tctcgttcaa ggcaaacaag cttttcccgc aactgagtaa tttcagagcc 25321 aagcaaaacc ttgtcagaaa tattttttat cataaaatca agttctttca catttgacgt 25381 cctgtccagg atattttttg tctggttaac ttccctgcca acattactaa actccgaacg 25441 caatctgtca agtttttcat attttgagaa aatatcagat gcctttttca aaatctccac 25501 tgcctcatcc acaaagcttg ttttttgcaa taccttttcc atttcttcca ttccggttaa 25561 aacctctgaa tacctctttt ttattcccag tatctgattt agcttgaaaa agcaggcttc 25621 cgcacttttt aaatacacac cgcactcttc cagcctgtca agccttgaaa gaattttggt 25681 ttgagccaaa tattcagtct caatgtcttt gagggaattc ttcttttcct caagcatatc 25741 aacttttgcc gtcaaagctt ccatccgggc gattactttc tcggactctt cgagtcttct 25801 tcccaattct tctatatttt tatactcttc aagttttttg tcaatatctt caatttctct 25861 ttcaatcctg tcacaagtct ggttttccct tcttatatcc gtggcacaat cctttatcgc 25921 ctggtcaatg atatgaagtc cggtaagtct cccaatggct tttgcccggg tggcaccgga 25981 ttccgacaaa agaaacggtc cttcaagctg ctctcctatg ttgagacttg cacggacatc 26041 catgtccaaa gccacttttg gaatcccatg agcctttaca atttccagag gcacttcatt 26101 tccgaaccct tcaaacacac tgacatttcc gtcagggtct ttgagcgtat atctgttttt 26161 gttaggtgcc ctttcccttg ttatgacata tccgttgcta agctccaaag taacccttgc 26221 agaatttgtt ccctgcctta taaaatcagt ccctctgggt tcattataca atacccattt 26281 aatagcccgg ataatggcag acttaccctg gtccgacggt cccacgatga cattgagccc 26341 gtcggaaaaa gaaagttccg tatccttgtg tgactggaaa ttttcaattc ttatcctttt 26401 tatcgtaatc attcttcatc ctgccctttt gccaagttct cccgtgcaat tcctatcctt 26461 cttaatgctt cctccttgac ttcacggcta agctcatcgc ttgacgcaat ttcttcaact 26521 atttgagaaa tatctatttt tttgtacctt cccgatgcct caattccctg gtaaaactgg 26581 tgcagcttta agttcctgtc ctttgcggct tcaagctttt cccggtcgag cacctcgtcc 26641 cccgggcggg cggttttaag ttcaatttct tctatatgta ttccgttttc gttaaattcc 26701 aggtaaacaa cctcaggttt tctttcaagt tcagtcagac tgctcgaaat cctcacaata 26761 cttcccgggt ttataaaata ttttgagtta atttttctga caccgaagcc gctgtgataa 26821 tgtccggcaa aagttatatc agcttccgtt tcttttatgt catccagcaa tgtgtatcga 26881 ataccttcat agaaaggctt taaaagaagc attccgtgca cgatgtttat ggcataatcc 26941 acatcggcac gtttttttac aatataataa tttctgaaat tctcgccgtc tatttcataa 27001 ttataagacc ttccggtaag ctgaacggtt atgccgtcct tttttaaaat cacttcatca 27061 tcataaacta aaagatttat tattcctgtt ccctcaagaa gaccaagcat cgttcttccc 27121 acagtcgcag gattatgccc gtaaatatca tgatttcccg caacagtata tatgggtttg 27181 ccgaaactct ttataataac ggcaaattcc ctgactatgg agggagaaat gtcgggtctt 27241 tcaaaccaat cccctccatg cagtatataa tcaacattat accgtcctga aatatctcct 27301 atctcataaa atttgttttt cagcgtctca taaaagttgt cttttctgtt tttcggcgtc 27361 gttcctctaa tgtgcgaatc cgtaaaaaaa gaaacttcat tggaacactc tctttccggt 27421 gctttttggc acaatcgatt tctataatac caatctctgt aatatcaaaa ggtgcttaca 27481 tactctcttt cttaattctt tcttcgtatt ttttattgta ttcctgccac cattcctgat 27541 tttgcacggt gcaaagctcc ttttccaaat gggaagtatc tccttcaagt actatgttaa 27601 actttccgtc ttcataatcc agtatggtta cagaagtgtt gtcataccat tgaatattta 27661 tcatctccgt aaggtcgcaa tttttaaaat aacacatcat ggaccttatt gccgtcccgt 27721 gggtgacaat gcatatattc ttgcccttgt tgttgtcaat aatgtatttt acttcatcaa 27781 tcagcctttt ctgaaattca accatggact ccccgccggg cattttatgt tcatgaggtc 27841 tgttctccca gctgtcgtat tcttccggcc acaatttggg cagttcttcc cattctctgt 27901 tttcccagtc ccctccgttt atttccttaa gtttgtcagt tcttattatg ggaaggtttt 27961 tcacatcagc aatatattgg gcagtctgaa gtgttctttt caagctgctg gaataaatta 28021 cgtcaatgtc aacatcttta agcctctggg caactctctg ggcctgaaga tgtccccttt 28081 cggtaatgga tgaatcggtc cagccgtgga acaccctgtt gagatttcct tcagcctcgg 28141 catgacgaac aaatataatt ctggttttaa ttgccatcac cctcttgcag ttattagttc 28201 caaatctata ttgtttacaa aattaattgc aacatataat caacataata tattatatca 28261 ttttatcagt tgagctgtaa ctttcctatt atttcataaa cactgccgtg attatacatt 28321 ttaaggtaat tttttattcc ttccacaaca tcaatgcatg ccgcaggatt tataaaattg 28381 gccgtcccca ccatcactgc gcttgcacct gccagcatga attccaccgc atcctcaccg 28441 cttgatattc cgcccattcc aataacgggt attttgacaa cactgcaaac ttcataaacc 28501 atcctcactg caatgggctt taccgcaggt cccgaaagtc cccccacatt gttggcaagt 28561 atcggccttt ttctgtgtat gtcaatggcc atcccgagaa tcgtgtttat aagggaaaga 28621 gcatcggctc cggctgcttc ggcggcgaca gctatttctt taatatcggt aacattggga 28681 gtaagcttaa caataagcgg ctttttgcag tattttttca ctttgctcgt aatctcgctt 28741 attcctgcag gagaattccc aaaagcaaca catcccttct ttacattggg acaggaaaca 28801 ttaagttcta ttgcgtcaat atccgcatct gacaaaagtt ctgccatctt gcagtaatcc 28861 tctatagtat tgcccgcaat attggcaatt atttttgtat tatactttct caaaaaagga 28921 atttcatttt ctataaaggc tctaacgccc ggattttgaa gccccacact gttaagaata 28981 ccggccggag tctcggcaat cctcggaggc ctgttcccct gccttttttc cagagtaagt 29041 ccttttaccg atattccgcc aattttattt aaatccacgt aatcaacaaa ctccctgcca 29101 aatccgaaag taccggaagc tgctataaca ggatttgaaa gcctcaaacc tgcaatatca 29161 acacttaaat caatactttt ctcagtcatc caaaatcacc tcatcactcc agaaaacagg 29221 cccgtcttta caaacatggc tgtattccca attatccggc tttccggttt tgcacgcgca 29281 cacaaggcat gctccgattc cgcatcccat tctctgctcc aaggacacct ggcatttgat 29341 gccggccctt tcggcaatat cctttacctt tctgagcatc ggcatgggac cgcaggtata 29401 aataatgtca aagccccttt cggcaatatc tttctcaaga aggtccgtaa ctattccttt 29461 atatcccaca cttccgtcat ccgtggatat ggaaagtctg tcggaagcgg cttcaaactc 29521 atcggtcagc accacataat cactgcttct gaatcctaaa aaagcagact tgtccgcgtc 29581 cttcatctcc cttaacagat aaagcagggg gaatatgcct attcctcccc ctaccaccgc 29641 aatacgttta tactgccggg atatgtgaaa aggttttccc aaaggaccaa tcaaatccac 29701 ttcgcttccc gcactttttt tgagacagat actcggttcc gattcccttt acctgaaata 29761 caatgtcaaa tgttcccctc tctacgtcgg cgctgcatat gcttatgggc cttcttaaaa 29821 gcgcgtttaa gccttcgcag cactttacgt tcacaaactg tcccggacgg gaatttacgg 29881 atatatattc agatttaacg gtcattttat aaattgattt tgctattttc tcaacacttt 29941 caattctttc cttcaacacc ctggacatgg catcctccga ttattggtta ttatcactgg 30001 ttatcaaata cgctcaaatc tataacttca aggtcttttt cctctttctc cagttttatg 30061 cattccagca cagcccgtgc agtatcaagg gacgtaaggc aaggtatcga catttcaacg 30121 gcttttcgcc ttattttaaa tccatccctt tcaggctgtc ttccttttgt aggagtattg 30181 attataaggc ttatttttcc tgattcaatc aaattcagaa gatttggctc accctcgcca 30241 atttttttca cggcattggt ggcaattccc tggttgttca gcatgttggc ggtttttccc 30301 gtggcataaa gctcaaatcc aagcttttca aattcttccg ccagctgtac aagctcaggc 30361 ttgtcggtat ccctgacagt catcagtatc gcgccgcctt ttttagggag cttgattcct 30421 gtcgcaataa ttcctttgta cagcgcctcc gggaaagttt ttgctatacc caaaacttca 30481 ccggtggact tcatttcagg tcccaggctt gtatcaacgt catgaagctt ttcaaaggag 30541 aacaccggaa ccttcaccgc cacatactcc gattctttgt aaagtcccgt tccgtaattg 30601 aaatccttga gttttttgcc catcattatc cttgtagcga tatttaccat aggtattccc 30661 gttaccttgc ttatatacgg aacggtacgg cttgaacgcg ggtttacctc gataacataa 30721 agctcgttat tgtaatacac atattggata ttgatcaatc caacaactct taacgctttg 30781 gcaagctttt gagtgtaatc cacaatcttt tccttgagct tttcccctat tgtctgcgtc 30841 gggtaaacgg atatactgtc cccggagtga acaccggctc tttccaagtg ctccattata 30901 ccgggtatca aaatatcctc accgtcggat atggcatcca cttcaatttc cttgcccatc 30961 atatacttgt ctatcaggat gggatgttcc tgctttaccc tgtttataat ctccatgaat 31021 tctactatgt ctttgtcgtt gtaagctatt tccataccct gtccgccaag tacatatgag 31081 ggtcttacca gtacaggata gcccaattcg tttgcagcct ccaaagcttc atcgagggta 31141 aatatagtct ttcctttagg tcttggaata ccgagttctt cgagaatcct gtcaaatttc 31201 tcacggtcct cggcggcatc aatatattta ggttcggtgc caaaaacttt tactcccatt 31261 tccacaaggg cttttgtaag tttaatcgca gtctgtccgc caaactgaac aattgccccg 31321 tctacttttt ctttttcaac aatgttctcc acgtcttcag gagtcaacgg ttcaaagtaa 31381 agcctatccg ctgtgtcaaa atccgtactt accgtctcag gattgttgtt tgcaattata 31441 gtctcataac cttcctgctt caatccccat accgaatgaa ccgagcagta gtcaaactca 31501 ataccctggc ctatccttat gggtcccgac cctattacca gcaccttttt cttgtccgat 31561 ttcttagcct cgcagcattc atcataggta gagtaataat aaggtgtcat ggcctcaaat 31621 tctgcggcac aggtatcaac cattttataa acggcacaaa tgccaagctc ttttcttttt 31681 gccgtaactt cctttttgtc gcatccaaca tattttgcta taaccgcatc ggtaaagccc 31741 atctttttaa ccgttcttaa ggtttcttcg tcaaaatccg aaagcttcat ggtttttaac 31801 ttttcttcca taaggaccag atttttgatt ttgtttaaga agaacaaatc tatctttgta 31861 acattgttga tttcctcaac cgttacgccc cttcttattg cctcggcgat aacaagaatc 31921 ctctcatcac tgacatcttt tatcttttgc cttatttctt cggcactgaa ctttttgtaa 31981 atatcctgtt ccagtgtgaa aatacccagt tccagcgacc ttaaagcttt catcagagcc 32041 ccttcaaaag agctgcttat agccataact tcaccggtgg ctttcatctg ggttcccaaa 32101 gtccttttcg cctttacaaa tttgtcaaaa ggccatttgg gtattttgat tacaacatag 32161 tccaaagtag gctcaaaaca cgcaaaagtc tttccagtca ctgcattttt tatttcatca 32221 agaccataac ctatggctat cttggtggca acctttgcaa ttgggtaacc cgttgccttt 32281 gaggccaatg ccgaggaacg gctcaccctt gggttgacct ctattaccgc atattcaaaa 32341 ctgttgggat ttagagcaaa ctgaacgtta cagcctccct cgatgcccaa tgccgatatt 32401 atcttcagtg ccgaggagcg aagcatctga tattctctgt ccgtaagcgt ttgggaaggc 32461 gcaacaacaa tgctgtctcc ggtatgaact cctaccgggt cgatattttc catgttacat 32521 acggtaatta cattaccctt gctgtcgcgc ataacctcat actcaatttc tttccaaccg 32581 gcgatacatt tctcgataag tacctggtgt actctgctga gcctcaaacc attggatgca 32641 atctctttca gttcttcttc attgtaagca attccgccgc cggttccccc caaagtatag 32701 gcaggacgca caacaaccgg ataagcgatt tcttttgcaa aatccagcgc atcctcaact 32761 gtgtttacca ccttgctggc aatacaaggc tctcctatcc tttccatggt atctttaaaa 32821 gcctgtctgt cttcggccat ttttatggcc tcggtggcag ttcccagaag ttttacgcca 32881 tgttccttca aaaatcctga ctctgcaagc tccatggcaa gattaagtcc tgtctgccct 32941 cccaaagtgg gaagtatgct gtccggtttt tcttttatta taattttctt tacaacctcc 33001 accgtaagag gttcaatata tactctatca gctatattgg tatccgtcat tattgtggca 33061 ggattgctgt taaccagcac cacttctatg ttttcctctt ttaaagccct gcaggcctgg 33121 gttccggcat agtcaaattc cgccgcctgg cctattacaa taggacccga gccgataacc 33181 aggacctttt ttacatcatc ccttttaggc atttaatttc ccccttatat aattaaactt 33241 cttacaagaa ttatcttccg aataagactt tgaagttcat aaataaaaac ttatatagct 33301 gtttaacgcg aatatttttt catcatatca ataaactcgt caaacagata agccgtgtcc 33361 tcaggccccg gtgaggcttc cggatgaaac tgcacggtaa acaccggcat atccttgtac 33421 cttacgcctt cgacagtgcc gtcgttcatg tttctgtggc ttaccgtcat ccttgatttg 33481 tccatggatg actcaacaat agtgtagcca tggttttggg aagtaatata tgtcaggtcc 33541 ttttcgaggt ccttcaccgg atggtttgct cccctgtggc cgtatttgag tttttcggta 33601 tcggcaccgt tggcaagggc tgtaagctga tgcccaaggc agatgccaaa catgggtttt 33661 ttgcccataa gcttctttat ggtctcaatt gtctcaacac aatccttcgg atcccccggt 33721 ccgtttgaaa gcattattcc gtcgggatta atcgcaagga tgtcctccgc tttggaattg 33781 gcagggaaaa catgcacgtc acatcctctt tttaaaaggg agcgcacaat atttttcttt 33841 aagcccaaat ctatcaatgc aactttaaat ccgtcacctt tataatgcaa aacttctttt 33901 gttgtgacac acataaccgg atcctttata acataagctt ttatttcgtc aatcttgtca 33961 tcaagattga aattcggatc cgttgaaatc attcccttca tcgttccttt ttccctcaaa 34021 atcctcgtaa gagccctggt atcaattttc tcaattccta ttatgttatt tcttttcaga 34081 tagttgttta acgtctcctc ggctctccag ttgcttgggt tttgacaaag ctcccttaca 34141 ataaaaccct ttacttgtgg cttttccgac tctatatctt cactgtttac accgtaattg 34201 cctatcaaag gataggtcat tgcaacaatc tgtccgcagt aagacggatc tgtcaaaacc 34261 tcctgatagc ccgtcatacc tgtgttgaaa acaatctctc cgattacttc tccctgagct 34321 ccgaaacttt cgccgtgaaa aattgtgccg tcttcaagag ctaaaatagc tttcataata 34381 tatcacctcg tattctaaaa tggaattact tcctgtctcg caacgcactg ttaatatcgt 34441 ccctcattct tattgcctcg gctcttgatg cctcataaaa cttttcttcg ctgtaaacat 34501 tcttccattg ttcagatttg taggcacaca ttatgcttct tgatgcattg acaattgctc 34561 cgagcccgtc ataattaaag caatgggcta catctctggc tgttcctccc tgagctccat 34621 agcccggaac cagtatatag gaatttttca gaatctttct taaaattttg gccagattgg 34681 gataagttgc tccaaccact gctcccacac aactgtatcc atattttcct tttttgtttt 34741 caccccatga ttcaacatac tccgcaacaa tctcataaat gcttcttcct tcctgggtga 34801 gtatgtcctg aatttctccg gatgacttgt ttgatgtctt gaccagaaca aatatgccct 34861 tgttgtactt gacacagtca tctataaaag gcttaatacc gtccacacca agatacgggt 34921 tgactgtcag ggcatccaca tcaaaaaccg cctcgcttat accttcatca atgtccgttt 34981 ttccaagata tgcggcagaa taacactggg cggtggaacc tatgtcgttt ctttttccgt 35041 ctgcaataac caaaagtcct ttttcctttg catatttgca agtttcataa aacaccctca 35101 tgccttcaag gccgtacatt tcataatatg caagctgcgg ttttactgca ggaacaatat 35161 cgtaaaccgc atcaataata tatttattga agaggagaat cgcctctgcc acagctttta 35221 aatttttccc gtatttttta tacatgtctt cctttataaa agacggaaca tattcaattt 35281 tagggtctaa tcctacaacg gaaggattat ccttttctct aatcttttca attaatgtat 35341 caataaacat agtttcattc tccttacata acacaatttg aaaatattgt taatacaaaa 35401 cattactgat ataaaatcac tgattaataa aacatttata aacatttgta aaacatcatt 35461 gcaaagtttt cggcggaatg tctaaagcag caccttttct ctgacaacaa cattgccgtt 35521 taccaaggta taatatacac ttccattcag cttgaaccca tgaaaaggtg agttcttgct 35581 ttttgacttg aatttgttga catccaccac aaattcttca ttcaggtcaa caatagttat 35641 atccgcgctt ctgcctgtct ccagcgtacc tttgttgata cccaaaagtt tcgaaggatt 35701 tacgcacatc ttttcaacca gctggctgat ggtaaggtgc cccggtttta caagataggt 35761 tatcgccaga ggcaatgccg tttcaaatcc gaccatgccg tttgcggcca aattaaattc 35821 aacatttttc tcatcggcat gatgcggagc atggtccgtt gctattatgt caatcgtgcc 35881 gtccttcagt ccttcaatca cggcctcaac atctcttctc gtcctcagcg gaggatttac 35941 ttttgcaagg gtgttaaaat ctttgcaagc ctcatcggta agaacaaagt agtgaggaca 36001 agtctcacat gtaactttta ccccgcgctt tttggcattc cttataagct ccaccgaaag 36061 ttcggtactc acatgggcta tgtgtatcgg aacctttgtg tactcagaca gtataatatc 36121 ccttgccacc attatttcct cagccgccga aggtataccc ttaagtccca taactgtgga 36181 ccagtagccc tcgttcatca caccgccgtc tgcaaggtcc agatcttcgc aatgggatat 36241 tacagctatg tcaaacatgg atgaatattc caaagccctt ttcatcagtg aagaactttt 36301 taccggcttt ccgtcgtcgg aaattgccac cgctccggca aatttaagtt cacctatctc 36361 tgaaagctct tcgccttttt gtccttttga tatggccccg atgggatata cattaacata 36421 cccgtcctgt tttgccttgt ttataatata tttcaccaca gccttattgt cacagacagg 36481 atccgtatta ggcatacacg ctatggaagt aaatcctccc attgcagcac tcatggtccc 36541 tgtttctata tcctccttgt attcaaaacc cggatctctc agatgacaat gggcatccac 36601 cagtcccggc agtaccagct tgccctcggc ataaattata tcaccgtttg aaatttcaat 36661 atctttgcct atctccgtta ttataccgtc ttcaaccaaa atatccataa taccgtttgt 36721 gttggttttc gggtcaacaa catgtccgcc tttaattaac actctcaccg ctatccctcc 36781 ttgttaaaag ataaagaaga gccatcctta cagcaactcc gttggtaacc tgttcgttta 36841 taaacgacct ttcggaatcg attaccgacg acggtaattc aactcctctg ttaaccggtc 36901 ccggatgcag tatcagagca tcctcttttg caagtttcaa gcgcttttca tccaatccga 36961 aaaatctcga atattctctc aggctcggga acaagccact tttttgtctt tccttctgaa 37021 ttctaagtcc cataaccaca tctgcgtcaa tcaaagcttc ctggacagtg gtaaagactt 37081 tcacgccggt cttgtccaat tccggaggca taagggtgga gggtcctgca acacttactt 37141 ctgcaccaag cttggtcatc ccccagatgt tgctccttgc cactctgctg tgatatatat 37201 caccgattat ggcaaccttc aaccccttaa gacttccttt tttctcaata atagtgaaca 37261 tgtcaagaag tgcctgggta ggatgttcat tcataccgtc acctgcattt attaccgatg 37321 cctttacatt cctggcaaga aggtgaggcg ctcccgacat ggaatgcctt attacgatta 37381 catccgcacc catcatgtca attgtctttc cggtgtctat aagtgtttca cctttggcaa 37441 cgctgcttgc ggccactgaa atatttgctg cattggcact taagtatttt gaagcaagct 37501 cgaaggataa tcttgttctt gtgctgttct cataaaacag ggtaattatt gattttccct 37561 gcaaatgagg agccttcttg tttttggata aaagaataac cttcattgtt tttgcagtat 37621 ttaaaatgta ttgtatttct tctgccgtta aatccttaag tcctaagagg tcttttgatt 37681 ttaaaatcat ttttacacct cacttaaaat aaacttttat cattaatatt attagtatca 37741 aatggcctca aaaaaatagt aaggataatg gtattcctta ctatttttca aaaatcaccg 37801 gatttttttc cgaacacatt ataaaagttt tatatttaaa aatgggaata atagtacaca 37861 ttttttgttg gacttttatt tggttattaa tgttgtcttt atagttgtcc ttgcaatttt 37921 tcataaatcg tacccttccc ttattaaaac ctcaaataat ttaatacccc taatgtctta 37981 cgcctttttc tatatcactt atagttacac aatttactcc gtcaatctca taaagtttta 38041 cgttcaccac ttcaagcctg gaggttggaa cattctttcc gacataatcc ggccgtatcg 38101 gaagctccct gtgacccctg tcaatcaaca ctgcaagctg aaccatttta ggtcttccag 38161 catccatcaa agcgtcaatc gccgctctta ccgtccttcc cgtatacaac acatcatcca 38221 caaggactat tttcttgtcg gttatcggaa aatctatttg tgttccgttt attatcggat 38281 gctcggaaag catgctcaaa tcatctctgt agagagttat atcgagaata cccaccggaa 38341 cgctctttcc ctcaacaccc ttgatttttt ccgcaatcat ctttgcaaga ggcactccac 38401 gcctttgaat gccgattaaa gcaaggttgt caacgccctt gtttttctca ataatttcgt 38461 gggctattct ggttatggct ctcataattg cgctttcatc cattatttca gccttatcga 38521 tcatctccaa cactccgata caagcttttt aatttatcat ttacaacaag ctctaaaaaa 38581 gcttcttacc agtcggcaag aagctacttt gcagcatacg cgcagcaaca ctattgaatg 38641 ttattcaaca tcatatctta ccttctgagt ctctctggac ttagttaaag gtttattatt 38701 taattctatc taatgttaac acaacaaaag ttaattgtcc atactttatt atatattttt 38761 tatatttatt ttaatttctc attttattat ctcattaaat ttttcacttt actatatctt 38821 tattatcttt tcaaattgat acccaatatg cctcctatgc ttcccgacaa tatcccaata 38881 ccaagcaata tcaacacata actgtttatg gcaaattccc tgtaaactat gctgcttacg 38941 agatacaaaa tcagcatata tataaatccc actattgcac cattgagcca tcccttactt 39001 tttacgtttt tggtggaaat ccatcccgct atcactatac taagcaatgt tgtaattatg 39061 acggcagttg acatgtattt gagcggaaaa tccgtaaatt taagaaaata cgcaaaaata 39121 gcaaacatcg gaattgtaaa caaataggat accagtatgc cctttataac cataataata 39181 tttgaatgcc catttaatat atttttggcc gcctgcccgg ttttgttaat cataaaaacc 39241 cccccaacag atatttttat actacaattt attatgtttg ttcaaaagtt agaaccaaca 39301 aagcaaacaa tttcaaataa aatgtttttt atcttttcaa ttttttatga aaatattaaa 39361 acttaaggca tgcatagaat aataaaacat tccaaactat aaattaataa aataaatgtc 39421 gtacgaattg attaaactat atatgaaagc tccagaatat cagaactttt aaaagtcacc 39481 ggcggaacac aaaataagac ttgataaaac tggaggttca attatgggat tttttgattt 39541 tttatttaat acgcaaagcg acacaaatac agataacagc aatgaccccg ctgaaaacag 39601 agcaaaaaag ttccagccct tcaaccagga gttttcgctg gacatgacaa cggagcctta 39661 cggtaataac atggatgaaa ccaacaactt ttattcaaac aacggagtgc aaattcaaga 39721 cgccaaaaac gtatttcgcc tggtgtacag cggtatcctt gccaagaaca atcctgagaa 39781 cctgtatgcg gtaataggct acggaaacaa ccttgcgtgg gaggatatcg aatcttattc 39841 aatgcgtaag ataggcgacc agaagtatga gttgttattc cccgtaaaaa ggccaggcaa 39901 tattaatata gcgttcaaag acgatgctga caactgggac aacaattcag gaatgaacta 39961 ttgttttgaa aaccacgttt atcagggtag ccattaggct acccctttta ttgtttttat 40021 aaagcagaaa aatttatgta ttttatgact cctcagagtc tacaactctg cttatggccg 40081 atcttataat ctttatctgg gttctttcaa cactggtctc aatagttatc tcatcatcct 40141 tgatatttat tatttttcct ataatacctc ccgttgtaat aatattatca ccggtcttaa 40201 gtgccttaag catttctgcg tgcttttttt ccctctttct ctgaggcaaa attatcatga 40261 gatacataat gacaataaag gccaacggca caatcaacgc acttataagc tcctgaatac 40321 cggctcctcc ttcttgcggc ataaaaaaac ctcctttcat ttttttgttt cgtcctgtta 40381 tttttgtatt gttaaattat aaattaaaac cgggttgtta aatacctgat tatattaaat 40441 aaaactatat ttttttatat ccgaatttac tgaaaaactc atctctgaaa tctaaaagcc 40501 tgtcttccat tatagcctgt cttacttttt tcataaggtt aatcaaaaat cttaagttat 40561 gccatgtggt aagtcttatt ccaagaactt ccccgctttt taaaagatgc cttatatacg 40621 cccgggtaaa attcctgcag gcataacaat cgcattccgg atctatggga gtataatccc 40681 tcgcatagat tgcatctcta actattattc ttcctttgct ggtcagaacc gtaccgtttc 40741 tgccgattct tgtcggaagc acgcaatcaa acatgtcaat tcccctgatg gctccctcaa 40801 tcagataatc cggacttccc actcccatca aatatcttgg cttgtcctca ggaagcagcg 40861 gaaccgtaac ctccagcatt tcatacataa tctccgcagg ctcccccaca ctcaatcctc 40921 caatggcata tcccgggaaa tccagttcca gcaattcata ggcactctgc tgtcttaaat 40981 ctttgtacat tccaccctgg acaattccga aaagagcctg tttttccgga tttctatgag 41041 catccttgca tcttttggcc catcgtgtgg ttctctccaa tgactttttt gcatagtcat 41101 aatccgcagg atatggaata cattcgtcaa aagccattat gatgtcggct ccaaggtcat 41161 tctgtatttt tatcgccatc tccggagaaa taaaatgctt cgaaccgtca atatgcgact 41221 tgaaagtcac accttcctcc ttgatatccc tcaaatcact gaggctgaaa acctgaaagc 41281 cgccactgtc cgtaagaatc ggcctgtccc agttcataaa accgtgaaga ccgccggcct 41341 cttttacaat atcctctccc ggcctcatat gaagatgata ggtattgctc aatattatct 41401 gggcctcaat ttctttcatt tcatccggag acataccttt aacggttgcc tgcgttccca 41461 ccggcataaa agccggggtg tcaaaacatc catggggagt gtatactctt cccaaccggg 41521 caccggactg tttacacttt tttataagct cataccttat agcactcata tctctttcgt 41581 tcctcatcat tccttgtgat taaaatttac taaaatttat ttaaacattt tatcatttta 41641 taaacatggc gtcaccaaag ctgaaaaatc tgtatctttc cttgacggca atattataag 41701 cttccaatat tttttcccgt cctgcaagtg cgcttaccaa cataataagt gtggattccg 41761 gcaagtgaaa attggttatt aatgaatcta caactttaaa tttgtatccc gggtaaataa 41821 aaatatccgt ccatccgctt tggggcctta caataccatt ttcatctccc accgtttcaa 41881 gcactctgca gcttgtagtc cccaccgcta ttattttgcc gccgttttgc tttgttgaat 41941 ttattttgtc gcagtcctct tcttttatcc ggtaaaattc gctgtgcatc ttgtgctctt 42001 ccaaattttc aaccttcacc ggcctgaatg tgccaagccc cacatgaagc gtcacataag 42061 caatctttac gccccggccg gccaattctt ccaaaagctc caaagtaaaa tgaagtcccg 42121 cggtgggagc cgcggcagag cctttgtatc ttgaatagac agtctgatat ctttccgcat 42181 catccagctt ttttgttata taaggaggca gcggtacaat accaatcctg tcaagaattt 42241 cttcaaaaat gccgtcatac tcaaatctta caagtctgtt tccttcctca actatctcaa 42301 taacctcggc tttaagctct ccatttccaa atacaaacct tgcccccggt tttgcctttt 42361 taccgggttt taaaataact tcccaaacgt ctccgttaat cctttttaga agaacaaact 42421 caattttgcc cccggtacct tccttttctc ccaaaagtct tgccggtata accctggtat 42481 cgttcagaac aaggcaatca cctttgttta tgtactcgac aatatcctta aatctcttgt 42541 gggaaatttt cccggtttct ttgtcgagta ccatgagcct tgacatgtcc cttttttcaa 42601 ctggttcttg agcaattaat tcttgcggca aatcataata aaaatcacta accttcataa 42661 tcaactaaca ccgtttcgta tttattttca cagtaccatt tattttaaga tattttatgc 42721 gatttatata gaataataca ttaaatcctt ctttcatgca aggttcaaat gcaaaaaact 42781 gcagaaagac acataaaagc tccggaaaac atttccggag cagtttcgac accaaaaaac 42841 gcaaaagcaa aatcaactga gcctacttgg attttgtcaa cctactcaac ttttgttccc 42901 gggaaataat gggtcagtat ctcttcatag gtaaatccgg cattcgccat gcccttggct 42961 ccttcctgac tcattcccac tgcatggccc cagccttttc ctttaaaggt ataggtcgtc 43021 ggaatcagcg aaacggtttt taaaccactt gaggtaacga catttatctt tccgtttgca 43081 ggacttacgg ttttaagtcc cgaagccgtc atcacctttt ttcctgcaag ctgagttttt 43141 accggttcac cgtcatttcc ttttacaaag atgtctgcat ccgtcgtaat gtcataccat 43201 tgactgtcaa ggtttaaaaa gcttcttgtt gagctgtttg tataaacttt ctctccctgg 43261 cttcctttca ctattacctc agttgctctt cccgcttcgg atctctttgt tatataaatc 43321 cccagtatgt cccctatttt tatgccacgg tcggtcatta tctgctttat ctgctgtgcg 43381 gtaaacgaaa cttcccaatt gtaatgccac gaatctcccg attcatattt atcttcaacg 43441 cttacaagat acggataccc ttcacttccc cagacattcc tcacatcctc ggttcttcca 43501 ccgctggagc tgaaataaaa cacttccgca ggttttccgt tgtatgtaac tatctttcct 43561 tttgtttcat caactgcttt attggttgct gccgtttctc cgtcaaagcc cttatacacc 43621 tgggaataca cagtggggca caagtcaaac tgaagccttt tgtatttgtt caagtttttc 43681 accgtatagg ttcttgcagc aacagcctgg gcttttaagg cctcagggtg ggaacttgcc 43741 tgtatctcat agggcacaac cccatacaaa tattcttcaa tattaatcac attaattacc 43801 gtcatgtcac ttccggatag tctcaaaatt tcaaatgctc cgcgatatct cttcccgtca 43861 tccccgttaa tccttaaaac accggtttca tcactgactt cgggatgcac ctggaatgca 43921 taatatagtg aatcaaacat cagcataacc tgtccgtctt ttgacagaac aactattctt 43981 gactcggacg gagatacaac actgtaatcc ccgatcttta aaaccggatc tatctgattt 44041 gttattgcct ttttggcttc cttctcgtca acataaaaac ccgtccagat ttgccagccg 44101 tcatcataga ctgcataggc attcacgcct ttttgtttca tttcagcaag gcttttggaa 44161 agagcactgt aatctttata atcttttcct atttttatat gataagctcc aataacttct 44221 cccgaaggaa ctttccccga agaaggattg aattccgaaa atccgtcgct tccttttaca 44281 aaaaatgcgt cttttcttat agtaaccgca ttaccggaag gctctttaag aaggcacgta 44341 aagccctttt ccgagaaata cccaaattga aggccttttt tgctgtccac agtaaagctt 44401 gaaactgccg aatactgacc cgtctgcgga tcattaaaca taaggcctat ccttactttc 44461 tccggaattc cttcatatgc atatacaatg aaactttgtg aaaacaatac cgacacatac 44521 attatcaata atgataatat caatcgaaac ataatagtct ttgatttgca atttgacatc 44581 aaactttcca ccatgttctc ctccgtattt gtcttttgta ttttactttt cagattatag 44641 aaagctccca agtcaaaaaa tcaacatttc aaaattataa ttaaatacaa tataaattac 44701 aattaatttt atttaattat aagacagtta attatatttt aaaatcatat atttcgacaa 44761 atatatagtt cgataaaagc ccttcgttcc cttccttgta acagaattgt aaagttaaaa 44821 tgcctgacaa aaaacgtata ttaatgcaaa atatgcatca tcctatttat atgcaagaaa 44881 ttgaaattga aaataacaaa gacaaatagt ttgacatatt atattttaga tggtagaata 44941 attaaaaata aagtttaata tcaaacttag tagcattttt tatgatgctt gatagaggcg 45001 cagttttcaa gagtaggctt tctgaaaagt ttgagcttta atgacgaaag ttgaaagggg 45061 aaactgccga aggttgtatc tgctcaaaca gatacaatct ggttatacgg ttaagagctg 45121 tataactgtc atcaatttat ttgatggagc gctatcagtt cataaaagct tgtagtgtat 45181 aactgtatta atacactaaa atcttgatga actgctggta ctcacaccag cttttttagt 45241 gttcttaaag tcaattgtga tgacatatcg cactatcaag ccataaaacc cggtatttaa 45301 taagtttata atatatatag gaggttattt tatgaaaaag gttaatttag cagtagtcgg 45361 agccaccgga atggtcggca gaacatttat caaagtgctg gaagaaagaa acttgcctat 45421 cgataacata tatttctttt cttcaagtcg ctctgctggt tcgactgtaa ctttcaacaa 45481 caaggaatat gtggtggaag agctcaccga gacatccttt gacagaggaa tagacatagc 45541 actgttctcc gctggagcaa gtgtcagtga aaaatttgca ccaatagcgg cttcaaaagg 45601 ctgtgtggtt gtggacaaca gcagctgctg gagaatgaac gaaaaagttc cccttgtagt 45661 accggaagtc aatccccagg acatttcctg tcaccagggc atcatagcca atccaaactg 45721 ctccaccata caggcggttg ttgtgctaaa gcccttacat gacaagtata aaataaaaag 45781 aatagtttat tccacatacc aggcggtatc aggagccggg cacaacggat acatggacct 45841 cgaaaacggt cttaagggag aacctccaaa gaagttccct catccgatag ccggcaactg 45901 cctgcctcat attgactctt tcctccctaa cggctataca aaggaagaaa tgaaaatggt 45961 aaatgagaca agaaagatat tgggagacta cagcatcaga attaccgcca caaccgtaag 46021 agtgcccgta ttcaacggtc acagtgaatc aataaacgtt gagtttgaaa aacagtttga 46081 ccttgaagaa ctcaaagaag ttttaagaaa tgcaccgggc gtcgttgttc aggatgacgt 46141 tgccaacaat gtttatccga tgcctattta cgcaagcgga agagatgaaa cttttgtagg 46201 aagaattcgt cgcgatgaaa gtgttgaaag cggcgtaaac ctctgggttg ttgcggacaa 46261 tataagaaaa ggcgctgcca caaacgccgt tcaaattgcc gaagaactga ttaaaatgtg 46321 gaataaataa ttacgatttg atcctcaaag tataatgagt acttttttac tattattaaa 46381 tataataaat tagttataat aatttttgtc atgtttaaat cacaagtata atgtgaaagg 46441 atgtcgatta tgaggaaacc aatatttacc ggtgctggag tggcaataat aacaccattt 46501 acagaaaatg gtgttaacta cgacaagctt ggggaactta ttgaattcca gataagggaa 46561 ggtatcgact caatcataat ctgcggtacc accggagaag catcgacaat gcctgacgaa 46621 gaacataaag ccgttataaa atataccgtt gagaaagtaa ataaaagagt tccggttata 46681 gcgggcacag gaagcaacga caccatccat gcggttgagt tgagcaagta tgcggaagaa 46741 gtcggcgcag acgcaatatt aagcgtaact ccttactaca acaaaacaac ccagaaagga 46801 ctttacgaac actttaaact gattgccgaa agtatcaaaa ttcctgtggt tttatacaac 46861 gtaccgggca gaaccggcct gaacattgaa ccaaagaccg taaaacagct ggccgaaatt 46921 gaaaatatag ttgccattaa agaatgcaac ataaaccagg tcggcgaaat cataagcatc 46981 tgtcctccgg actttaccgt atattccgga aacgacgaca tggtagttcc tcttcttgct 47041 ttaggaggca agggagtaat atccgtaatg gcaaatatta ttccaaagaa aactcatgaa 47101 cttgtggcca ctttccttga cggaaatgtt gaagaaagca gaaaaattca attaagcctt 47161 ttaaacctca ttaaagcatt gttcattgaa gtaagcccta ttcctgtcaa agcagcaatg 47221 aatctcatgg gcatggaagt cggaaagtgc cgtctgcctc ttacggatat gaccgagaaa 47281 aactttgaaa ttttaaagca aaccctcaag gattacggcc tgatttaaac cacgccgtaa 47341 tcctgatgaa ataatgtaca aatgcaaaaa ggagaagtgc tgctcaaatg ataaacatat 47401 tattaagcgg atgtaacgga aaaatgggac aggtaatcag caagcttgct tcggaaaagg 47461 aaaacgtaag aattgccgcg gggctggata taaatacatc aatacagaac ccttaccccg 47521 tttataccga tataaacaaa tgcgatgtta aagttgacgt aatagtcgat ttttctcatc 47581 cttctgtttt acaaaacttg ctggaattcg ccattgcaag aaaaataccg gcagttatag 47641 caacaaccgg tcttagcaac tcccaggtaa aaatgctcca tgaggcgtca aagaacatac 47701 ccatatttta ctcagccaat atgtcaatag gtgtaaacct catgctggac ctggtaaaaa 47761 aagcggcaaa agtgcttgaa ggcaattttg acatagaaat catcgaaaag caccacaacc 47821 aaaaaattga tgctcccagc ggaaccgcac tgaccatagc cgatgcaata aattccgttt 47881 tgagtgaaga gcatgagtat atttatgaca ggcattccag aagaaaaaag agaaacaaaa 47941 aagaaatagg tatacatgcg gtaagaggcg gcaccattgt cggcgagcac tctgtaatct 48001 ttgccggcaa tgacgaaata attgaaataa aacacactgc cacatcaaaa tacatatttg 48061 ccgaaggctc attaaacgca gcagtgtttt tacatgataa acaaccgggc atgtacacta 48121 tggatgacct tatcaaaaat aaatagaatt ctgccagggg gtgtttgcat gtcccaaaag 48181 gtggatgcaa atatcgatat gtcttatgac acggcacttg tgacaattcg aaatgtccca 48241 aatgatataa gacttgtttc cgatattttt acttccatag cagatgaaaa catcaatata 48301 cagatgataa ccaaaactcc gccaaacaga ggatatgtaa acatactttt ttgtctgcct 48361 tcagaagatc ttttcacagc ccttgccgcc ataaacaggt gcaaagaccg tgccaaagat 48421 cttttgattg aagttgatgc ttacaataca aaagtatccc tatatcgtag agaaaaaaag 48481 aatttcagaa accttgtggc agaacttttc aggggctttg ctgacgaagg gatagatatt 48541 aaattcgcta catcttccga atcagagata tcctgtctga tttgcgaata tgactccgac 48601 agggctgcat cactgataaa agcataaaat cattgattta gttaagcggg gatttattcc 48661 ccgcttaaaa tattttctga ttaaaatttt gttatcaggc catttatgta aaatcaatac 48721 tctatacctt ttcttgctcc tattcctctc tcaaaaggat gctttttaca cacattatga 48781 gatacataat cagcaagttc aagtatttta tccggggcat cccttccagt taaaattatt 48841 tcaacaccgg aaggcttgtt tcttaaaaca tccgcaacat cgtcaacatc aattaatccg 48901 gtattaattg ccgccattat ttcatccagt atcaatatat cgcattcttc tttctgaagc 48961 acggctttca caaagtcaaa cgcagtttta acctcatttt tcagctctgc aatctctttt 49021 tcatccatat taaatataaa tccgtgtttt ttttcaaacc gaaaaatttt aaagccgggc 49081 tccagcttct caaggacctt tagttccccc gtatcctgac tttttaagaa ctgcaccata 49141 tacacggtat aacctctgcc aagagccctt atgccctgcc ctatggctgc agtagtcttg 49201 ccttttccgt ccccggtata aacctgaatc aatccctttt ccacttgccc aacaccctct 49261 tttctctttc tagcactttg tatattctaa caatagtgtt ctattatttc aatctaaaat 49321 tcaaaaattc atacaaagac caagcccgtt gcagaacaaa gtcatgttct catcttcaga 49381 tataaatatc attgttctta ttgttatttg caaatataaa ctgccatgct ataatgaagt 49441 aaaaaggcaa tataagacag attatgaagg aggtgtaaat aatagtgaaa gttttttgca 49501 ttatcattgc cattgtactg tcattattta attctccttt tacacaggtt gcaaatgctg 49561 ccggaataaa aagtacagat aacattaaat ttaaggaaat aacccaaatg gattttaaag 49621 atgttcatca tattgaaatt atgaacggta ccaccggaaa atttgttata ataaaatctt 49681 ccaaattaat tgaagatatt tttgcagctt tcaacaatgc tacatataaa ataaaaacag 49741 aggacggaaa tagaggtgga tggagttatg cggtatcttt tttcacttcc ggtatgaaca 49801 ccccatttta cattgataaa aacattaaaa aaatggatac cacacccgtt ttgattaacg 49861 gcagaacata tataccggtc agatacatag cagaagcatt taatatgaaa gtaaactaga 49921 acggaaaaga acgaacagta ttattaaatt gacctaaaca aaagagtaat tcttagtttg 49981 taaagaacta taaagcactt atgatctata aagcacttag aagttcatct gtaagtgctt 50041 tttttaacaa gtgaaaattt caaattccaa aaaattacac taaaatttta ttaaaaaaag 50101 tattgacata ttggtttaat gctagtataa tggattttgc tgaagcgcga taacaacata 50161 atacaatatg cggtcgtggt ggaattggca gacacgtacg tttgaggggc gtatgcgaaa 50221 gcgtgtgggt tcaaatccca ccgaccgcac catgaacaaa gaagagggaa aacgttcctc 50281 ttttttattt ttaaattttt atgttcacca cccctataag ccaacttcaa aaagagctta 50341 tctaacaagc acccctttac ctccggctga atagaatata gtatcttgag atttgcggag 50401 gtgaataaga tgtctggtat cttcaaaaag aatttcttta atgacaacag cgaaatttta 50461 ttctttatca ttcttttcct gttactgttc ttcaacggaa aagattatga caaatatggc 50521 tgctaacaag aaaagataaa attcagcggc cggcaagggt cggtaagttt tcaaaaagcc 50581 ctctgacaaa atggtataac actcggaaac atacataccg taaaagttgc ctgaaaatta 50641 tttatgaaat tgtatccaca aaggctctgt aaaggtatgt atgtttccga tttacattct 50701 tcctcttcat ttatataatt ctatataatt ttgtatcgct tataatttat ataatttaca 50761 tatataactt gtacttgaat actgtaatca aacatattaa aatcaaataa ccaaatatcg 50821 tcaagaaatt tttacaggct gtatcttttt tccatcgata catgttttta aggaaagcat 50881 ctttgttcca acaccttcaa attcaatcac aattaaatct ttagactcat caatcctggt 50941 taccaagcct tgtccgaatt ttacatgttc caatattgcc ccctcgcaaa tttcattggg 51001 cagggctctg ctttcagtct gcttttggac aagattaaac cggtgaacaa atcttgatac 51061 cgaaaccggc ttgttattta cctttgaaaa agttataagc tcaaggtact ttcttgctct 51121 ggtaacaccc acatagaaaa gccggacctc ttcctccatc aaagcgtcgt tgccttcctt 51181 gcaatcgctt atgctttttg atgacggaaa ttgcccgtcc accaggtcaa tcatatatac 51241 tttgtcaaac tcaaggccct tgcttgaatg tatggtagtc aaaacaactg catttttgta 51301 cctgtttttg ccggaatttt caatagctga tttcagtatg gaaagccttc cgaaaaactc 51361 atcgaaggaa tcaacccttg aagctatcga ttttaagccg tcaataatat aattaagact 51421 atcaatggaa taccccattt cctttgatgc cctgcgaata tatttttcat actcacattc 51481 cttttctata aattctattg ccttcaaagg cttcaaataa tcaatggttt caatctgtcc 51541 ggccaagtat ttaacagcat tacaggtgtc ttcgggcaaa ttggggaaat tcagcaaagt 51601 ttccatgaca cccttcccct ttcccatgtt ctcagcaaca tactcaaaca tctcacggct 51661 tataaaagca ccgattttgt agtaaatttg cccaaaagcc tcaatatcac aaggatccaa 51721 ggcaagccgt ataaaagaaa gaacgtcatt taccacccaa tgcttgaaaa aatgaagatt 51781 ggtatctctg atataaaaag gtatgttgtt gtattccaga taatccacca gtggaatggc 51841 agaaatatta ttcctgtaaa gaacggcaca ttccgataaa ttactctcag attttaaaac 51901 cgaagtaaga tatgcatact gttcattgcg attttttaca tgcttgaata ccacggcctc 51961 gccttcttca ttttcagtat acatattttt ttcatatcgc cctttgttct gctttataaa 52021 aatatttgcc ggaatcacaa tgctctttgt ggaacgatag tttctttcca ttaataaaat 52081 ttttgcatca ggataggttt ttttaaaatc aagaagcgct tggggaaaag cagccctaaa 52141 cccataaatg ctctggtcct catccccaac catgaaaata ttgttttttg ggtgggcaac 52201 aagctttata atttcatgct ggaccaaaga tgtatcctgg gattcgtcta cattgatata 52261 atggtacctt tctcttaaca tattagtaat cccggtattt cttttaagaa gcttataagt 52321 cccggtgagc atgtcgtcat aatctatata tccttctgac tttttacgtt tttcatatgc 52381 attgtaaata tcaataaaat ttttgattcc gatatccaat ttttttatat catcctcagt 52441 gtaaagcata tttttgacaa agctcacaga gttggacaaa tcctcaagcc tgtcgtcgct 52501 gatatactca ttgtttactt catggtaaat ccgctttaac atctggtttt tggaaatctg 52561 gccttcaccg tcttcaagaa tctggggcat gggtttgttt ttgctttcaa catagcagcg 52621 cacaacactg tagcaaaagc tgtgaatggt tgaaaacacc atattacgtg ccagctcttt 52681 tccgaagata tcacaaaacc gggtcttcat gtcctgggcc gctgccttgc tgaatgtcag 52741 cgtaagtatt ttttccggag gtattttatg atttagaacc atattggcgc accttgacac 52801 aattacggtg gtttttcccc ctcccggcac ggaaagcaaa agtgaaggcc cgtgaattcg 52861 caaaacagcc tccttttgct ggggattcaa attaatattg tatttgtctg acaaaagcct 52921 gaaaaactct tcctgattca tagatttccc atctctttct cccaatttca attacttatt 52981 ttagcatttg ttgaaaaata aataaagaag acagaagtta tgatatactt taagtggaaa 53041 atttcaagca aactaaatcg caagcagaat tgcaagtaga caagcagaat tattactttt 53101 ttatttttca aaaacactaa ctgttcagag gagatgaacc tatgaaactc attgatctta 53161 cccataaaat agaagacctc cttccggaat atccgggaga tgaggaaaca agactcgtta 53221 acacacgaaa actaaaaaca gacggctata ccaaccacag gcttcatata gacatgcatt 53281 cgggcaccca catcgactcc cccatgcatt ttgtcgagtc aaagaaatat atttgcgact 53341 accccataga atcctttatc ggcgagggat gcataattga cgcaagaaat gagccggtaa 53401 tcaaattaaa aaaagaatac aaagatataa taacagatgg ctgtatcctg ctgctttata 53461 ccgggctgta ccgtaaattc gggacagagg agtattttaa //