LOCUS NZ_ACVX01000029 50534 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00028, whole genome shotgun sequence. ACCESSION NZ_ACVX01000029 NZ_ACVX00000000 VERSION NZ_ACVX01000029.1 GI:256005384 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 50534) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 50534) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000029. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..50534 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene complement(98..1492) /locus_tag="ClothDRAFT_2210" CDS complement(98..1492) /locus_tag="ClothDRAFT_2210" /inference="protein motif:TFAM:TIGR01316" /note="TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH)" /codon_start=1 /transl_table=11 /product="glutamate synthase (NADPH), homotetrameric" /protein_id="ZP_05430349.1" /db_xref="GI:256005385" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000759" /db_xref="InterPro:IPR001327" /db_xref="InterPro:IPR006004" /db_xref="InterPro:IPR013027" /translation="MPNMSPKKVPMPEQDPNVRIKNFLEVALGYTEQMAMEEAQRCLN CKHKPCVSGCPVNVKIPEFVQLIAQGKFEKAYNKIRETNNLPAICGRVCPQENQCEKF CVRGIKGEPVAIGRLERFAADWHMKNGTTSYEKPEKNGKRVAVIGSGPASLTCASDLA KLGYEVTIFEAFHVPGGVLMYGIPEFRLPKKLVQEEIETIKQLGVEIKTNMVIGKVYS IDELKAEGYDAIFIGSGAGLPSFMKIPGENLNGVYSANEFLTRINLMKAYEFPNCDTP VKVGKNVAVVGGGNVAMDAARSAKRLGAENVYIVYRRSEAEMPARLEEIHHAKEEGIL FKFLTNPTRILGTDDGWVKGMECIEMELGEPDESGRRRPVPKPGSEHVIDVETVIIAI GQTPNPLIASTTPGLATQKWGGIIVDENTGATNIEGVYAGGDAVTGAATVILAMGAGK KAAKAIDEYLKNKK" misc_feature complement(101..1492) /locus_tag="ClothDRAFT_2210" /note="putative oxidoreductase; Provisional; Region: PRK12831" /db_xref="CDD:183780" misc_feature complement(<962..1069) /locus_tag="ClothDRAFT_2210" /note="Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644" /db_xref="CDD:187400" gene complement(1485..2330) /locus_tag="ClothDRAFT_2211" CDS complement(1485..2330) /locus_tag="ClothDRAFT_2211" /inference="protein motif:PFAM:PF00175" /note="PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: dol:Dole_0316 ferredoxin-NADP(+) reductase subunit alpha" /codon_start=1 /transl_table=11 /product="oxidoreductase FAD/NAD(P)-binding domain protein" /protein_id="ZP_05430350.1" /db_xref="GI:256005386" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /translation="MFKIVKKKILNPQVKLMEISAPHVAKKAEPGQFIILRVNENGER IPLTIADFDREKGTVTIIFQEVGKTTKLLGTLEEGDELLDFVGPLGKASHFENVKKAA VIGGGLGTAIAYPQAKKLHSMGVEVHTIAGFRNKDLIILEDEMRAVSSKLFITTDDGS NGNKGFVSDVLKKLIEEGNKYDLVVAIGPLIMMKVISELTRPYGIKTIVSMNPVMIDG TGMCGGCRVTVGGEIKFACVDGPDFDGHLVDFDEAMRRQAMYKKEESLALEKHNCKLG VEKNA" misc_feature complement(1503..2330) /locus_tag="ClothDRAFT_2211" /note="ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222" /db_xref="CDD:180476" misc_feature complement(1584..2327) /locus_tag="ClothDRAFT_2211" /note="FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219" /db_xref="CDD:99815" misc_feature complement(order(1689..1694,2007..2009,2121..2129, 2139..2147,2187..2198,2202..2204)) /locus_tag="ClothDRAFT_2211" /note="FAD binding pocket; other site" /db_xref="CDD:99815" misc_feature complement(order(2187..2192,2196..2198)) /locus_tag="ClothDRAFT_2211" /note="FAD binding motif; other site" /db_xref="CDD:99815" misc_feature complement(order(2061..2063,2067..2069,2094..2096, 2106..2108,2115..2117,2124..2126)) /locus_tag="ClothDRAFT_2211" /note="phosphate binding motif; other site" /db_xref="CDD:99815" misc_feature complement(order(1995..1997,2001..2012,2022..2024)) /locus_tag="ClothDRAFT_2211" /note="beta-alpha-beta structure motif; other site" /db_xref="CDD:99815" misc_feature complement(order(1764..1769,1929..1937,2004..2009)) /locus_tag="ClothDRAFT_2211" /note="NAD binding pocket; other site" /db_xref="CDD:99815" misc_feature complement(order(1620..1622,1656..1658,1665..1667, 1680..1682)) /locus_tag="ClothDRAFT_2211" /note="Iron coordination center; other site" /db_xref="CDD:99815" gene 2836..4170 /locus_tag="ClothDRAFT_2212" CDS 2836..4170 /locus_tag="ClothDRAFT_2212" /inference="protein motif:PFAM:PF00208" /note="PFAM: Glu/Leu/Phe/Val dehydrogenase ; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: glo:Glov_0573 glutamate dehydrogenase" /codon_start=1 /transl_table=11 /product="Glu/Leu/Phe/Val dehydrogenase" /protein_id="ZP_05430351.1" /db_xref="GI:256005387" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /translation="MKLLAGVMEQVIKRNPNEPEFHQAVREVLESLEIVAEKNPEYLK AGIFERIVEPERQIIFRVPWVDDNGKVQVNRGFRVQFNSAIGPYKGGIRFHPSVNLGI IKFLGFEQIFKNSLTGLPMGGGKGGSDFDPKGKSDGEIMRFCQSFMTELYRHIGPDTD VPAGDIGVGAREIGYMFGMYRKIRNEFTGVLTGKGLTWGGSLVRTEATGYGLCYFMEE AMKTIKGKSFEGATVVISGSGNVAIYATEKAQQLGAKVVALSDSNGYVYDPDGIKLDT VKQIKEVERKRISEYVKYHPNAKYTEGCSGIWSVKCDVALPCATQNELDGNAAKTLVE NGCYAVGEGANMPCTPEAIDIFMKNGVLYAPGKASNAGGVATSGLEMCQNSMRYSWSF EEVDAKLKDIMVNIFRNVRAVAKEYGQEDNLVLGANIAGFLKVANAMMAQGV" misc_feature 2836..4167 /locus_tag="ClothDRAFT_2212" /note="glutamate dehydrogenase; Provisional; Region: PRK09414" /db_xref="CDD:181834" misc_feature 2995..3387 /locus_tag="ClothDRAFT_2212" /note="Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812" /db_xref="CDD:145786" misc_feature 3409..4167 /locus_tag="ClothDRAFT_2212" /note="NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313" /db_xref="CDD:133455" misc_feature order(3550..3558,3616..3621,3790..3795,3862..3870) /locus_tag="ClothDRAFT_2212" /note="NAD(P) binding site; other site" /db_xref="CDD:133455" gene 4370..5905 /locus_tag="ClothDRAFT_2213" CDS 4370..5905 /locus_tag="ClothDRAFT_2213" /inference="protein motif:TFAM:TIGR00884" /note="TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; KEGG: glo:Glov_1901 GMP synthase" /codon_start=1 /transl_table=11 /product="GMP synthase, large subunit" /protein_id="ZP_05430352.1" /db_xref="GI:256005388" /db_xref="InterPro:IPR000991" /db_xref="InterPro:IPR001317" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR006220" /db_xref="InterPro:IPR011702" /translation="MNNELILVLDFGGQYNQLIARRVREANVYCEVLPYNSSIDKIKS KNPKGIIFTGGPASVLDPKAPICDREVFELGIPILGICYGMQLMSHMLGGTVEKAEQR EYGKVNITFDTSSMLFEGIEKESTCWMSHTYYVNNLPEGFVKCADTPNCPVAAIENRE KKLYGVQFHPEVVHTPKGRDILNNFLYKICGCSGDWKMASFIEHSINSIREKVGDKKV LCALSGGVDSSVAAVLVHKAVGKQLTCIFVDHGLLRKYEGDQVEEVFKKQFDISLIRV NAEDRFLEKLKGVTDPERKRKIIGEEFIRVFEEEAKKIGTVDFLVQGTIYPDVIESGV GDAAVIKSHHNVGGLPDYIDFKEIIEPLRSLFKDEVRKVGIELGIPEDIVMRQPFPGP GLAVRVIGEVTKEKLDILRDADYIFREEIKNAGLDREINQYFAVLTGMRSVGVMGDER TYDYTLALRAVTTIDFMTADWAKIPYDVLEKVSNRIVNEVKHINRIVYDITTKPPATI EWE" misc_feature 4370..5902 /locus_tag="ClothDRAFT_2213" /note="GMP synthase; Reviewed; Region: guaA; PRK00074" /db_xref="CDD:178842" misc_feature 4385..4927 /locus_tag="ClothDRAFT_2213" /note="Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742" /db_xref="CDD:153213" misc_feature order(4406..4411,4529..4537,4613..4618,4757..4759, 4874..4876) /locus_tag="ClothDRAFT_2213" /note="AMP/PPi binding site; other site" /db_xref="CDD:153213" misc_feature order(4532..4534,4616..4618) /locus_tag="ClothDRAFT_2213" /note="candidate oxyanion hole; other site" /db_xref="CDD:153213" misc_feature order(4613..4615,4874..4876,4880..4882) /locus_tag="ClothDRAFT_2213" /note="catalytic triad; other site" /db_xref="CDD:153213" misc_feature order(4625..4627,4760..4762,4868..4870) /locus_tag="ClothDRAFT_2213" /note="potential glutamine specificity residues; other site" /db_xref="CDD:153213" misc_feature 5018..5899 /locus_tag="ClothDRAFT_2213" /note="The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997" /db_xref="CDD:30184" misc_feature order(5018..5092,5096..5128,5132..5164,5195..5308, 5324..5368,5390..5419,5432..5437,5441..5509,5525..5569) /locus_tag="ClothDRAFT_2213" /note="ATP Binding subdomain; other site" /db_xref="CDD:30184" misc_feature order(5030..5038,5042..5053,5105..5107,5111..5113, 5468..5470) /locus_tag="ClothDRAFT_2213" /note="Ligand Binding sites; other site" /db_xref="CDD:30184" misc_feature order(5594..5632,5657..5686,5693..5725,5735..5782, 5801..5827,5831..5899) /locus_tag="ClothDRAFT_2213" /note="Dimerization subdomain; other site" /db_xref="CDD:30184" gene 6075..6428 /locus_tag="ClothDRAFT_2214" CDS 6075..6428 /locus_tag="ClothDRAFT_2214" /inference="protein motif:PFAM:PF03965" /note="PFAM: Penicillinase repressor; KEGG: ccs:CCNA_01712 beta-lactamase repressor" /codon_start=1 /transl_table=11 /product="transcriptional repressor, CopY family" /protein_id="ZP_05430353.1" /db_xref="GI:256005389" /db_xref="InterPro:IPR005650" /translation="MQKLYDSEIKVMEIIWENEPISAKQISLIAAEQIGWNKNTTYTV IKKLESKGYIKREEPGFICTSLISREDVCRAETQSLIDKFFGGSKKALFSALLQDEKL SSEDLDELRRMIEER" misc_feature 6090..6422 /locus_tag="ClothDRAFT_2214" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:185792" gene 6435..7343 /locus_tag="ClothDRAFT_2215" CDS 6435..7343 /locus_tag="ClothDRAFT_2215" /inference="protein motif:PFAM:PF05569" /note="PFAM: peptidase M56 BlaR1; KEGG: swd:Swoo_3738 TonB family protein" /codon_start=1 /transl_table=11 /product="peptidase M56 BlaR1" /protein_id="ZP_05430354.1" /db_xref="GI:256005390" /db_xref="InterPro:IPR008756" /translation="MLSEMFYWLFNMSISASVAGIVVLLLRRIKKLPRRLVHILWVIP FIRMWIPVGIRSKYSLMTLISKFTTKSVVLYDGTLDFSFTNYIMAADNYFPVTYKEDM LENLFSIASVVWIIVAVALSLIFAILYVLAKSELKDASLLRDNIYVSDKITSPAAYGV FRPKIVVPKGYELRNLHYIVAHESAHIYRKDNLWRIIAVISASVHWFNPLIWLFLKKF LEDTELACDEQVLANCGEDEKKAYAMALVDCAESMGVFASPFGGAKIRVRIDRILSYR KLSIISIASLTAFAVAIGYVLLTNAS" misc_feature <6867..7220 /locus_tag="ClothDRAFT_2215" /note="Peptidase family M48; Region: Peptidase_M48; cl12018" /db_xref="CDD:187163" gene 7357..7965 /locus_tag="ClothDRAFT_2216" CDS 7357..7965 /locus_tag="ClothDRAFT_2216" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430355.1" /db_xref="GI:256005391" /translation="MKKIFNVCCVMMLLIFVLSGCSKTATSYGEGNDLKYVTDNFTLE DAKREGYVVIEDGDVTFGQEAWQNFVDLSSKKIPCKIRVVHYYPIGDSSNYDPEYYES IKDDYPKMYILELVYNGEIFRVSHYEGEELYESEFKYLVKYEGKAETPDATYTSFVRY VLVNDDKVTWDDIMHGVFSSRLGDYISYRVIYTDLVYKEEYK" sig_peptide 7357..7431 /locus_tag="ClothDRAFT_2216" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.784 at residue 25" gene 7962..8924 /locus_tag="ClothDRAFT_2217" CDS 7962..8924 /locus_tag="ClothDRAFT_2217" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: noc:Noc_2864 phospho-N-acetylmuramoyl-pentapeptide-transferase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430356.1" /db_xref="GI:256005392" /translation="MSQFKKFCIFSLVGVLVASFYPIFMGLKVIDDMVRNGVVLAENY PKYIIPYTPISLAVIIAVLLLPVLMRYTKKYALATATLISLLVFFVSELLLENMVIIT DNVTTTLESWQMFMCYVPPESVRTRTWKPVDVLIGDYSPAFKIHFYAISVVLIITLVN CFYGFAKIIVTKDKRRLKALIFQALLTVLFLGLCIFACFTAFFRDGEITVSAVSAILM SLFFVVFGLTSGVYAGSFLVGKKKTLAVLLPSIVASSVTIVMYIGEMVLLSGHLYRFG TGFLFEEFPGIVLAPVDILVIVASGCINAVICHAFGESGKRIKN" gene 9050..9289 /locus_tag="ClothDRAFT_2218" CDS 9050..9289 /locus_tag="ClothDRAFT_2218" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430357.1" /db_xref="GI:256005393" /translation="MGLGNLKTYGGLRQGSQSYNIDRLKKYLYYGDGTYDDLVNTLLN EAMNDQLESFASFYRGKKLYELPRGWPEIPAKRQR" gene 9306..10028 /locus_tag="ClothDRAFT_2219" CDS 9306..10028 /locus_tag="ClothDRAFT_2219" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430358.1" /db_xref="GI:256005394" /translation="MAMTPIEMIEFCDSQVNGGIQRGLEKGKANGDYYLIALNYDEGF KCRLMQTLISWRIGIGNPKEYLIKAIDIANEAISTLSKFETKNILKDFPVDTALIASY LAERPLYVDENLNMNTSGLPFEVILDLEMAKTLRGANNEDAWSSIIDQYKQKKRSALC YNTYCLYKELLFTEDAEKVEPIVRQLEKLFLKRKKNPYYSGGELTEGGGPSNDVTVDY RLGAILKFKSFKGESIHLWRWD" gene 10275..10757 /locus_tag="ClothDRAFT_2220" CDS 10275..10757 /locus_tag="ClothDRAFT_2220" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430359.1" /db_xref="GI:256005395" /translation="MSIIKYDYNNVVQLFVKNLSESKEYHKNYLELISKIKQMDGVVD IGSFCYGSISFKELDENINLRKRVFSAIGKTDQFENIPLLNALYIESAMIHILEPPIY KGRFFESEDFEESDEIPLVVGYAYKDIFEIGQTFTVTDESLGMAGTYKVIGILDKGSY " gene 10821..11048 /locus_tag="ClothDRAFT_2221" CDS 10821..11048 /locus_tag="ClothDRAFT_2221" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430360.1" /db_xref="GI:256005396" /translation="MARELYENNIFVLTLNSKMLYVVGGNLSNVDAVRRKISDLAKEY KMSIRQMTVKEYNDAKNSEYMEGESARIFTS" gene 11051..11416 /locus_tag="ClothDRAFT_2222" CDS 11051..11416 /locus_tag="ClothDRAFT_2222" /inference="protein motif:PFAM:PF02687" /note="PFAM: protein of unknown function DUF214; KEGG: lch:Lcho_3709 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF214" /protein_id="ZP_05430361.1" /db_xref="GI:256005397" /db_xref="InterPro:IPR003838" /translation="MIILSVFGIMSISAAKLLSKRREIGIRLSFGTSKRGIIFIFSGE LFILFVISLLITLLIHNISIINKSEMKKYFYNFSYGLNIQSVGVLLGIIVLIFIFSCI VPIITIKKFSLRDLIGGYE" misc_feature <11051..11299 /locus_tag="ClothDRAFT_2222" /note="Predicted permease; Region: FtsX; cl11418" /db_xref="CDD:187029" gene 11416..12129 /locus_tag="ClothDRAFT_2223" CDS 11416..12129 /locus_tag="ClothDRAFT_2223" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: vpa:VP1995 ABC transporter, ATP-binding protein" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430362.1" /db_xref="GI:256005398" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /translation="MKNAIIRLENISKIYGKDDYKTVALKDINLEIFEGDFVSIMGPS GSGKTTLLNIIGFIDTPTDGKYFLKGQDVNKMARGKFHKLRGTEVSFIFQQFALLKDY TAYENIQLPLLYRKMSRKEKKAKILFYAEKLGIGDILHKKPSQLSGGQQQRVAIARAL ASEANIILADEPTGALDQKKGNELMKILAGLNKEGKTILVVTHDPNIANYCIRNIRIE DGKIISDSSSLQDEPLKTC" misc_feature 11428..12093 /locus_tag="ClothDRAFT_2223" /note="ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136" /db_xref="CDD:31331" misc_feature 11431..12081 /locus_tag="ClothDRAFT_2223" /note="This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255" /db_xref="CDD:73014" misc_feature 11539..11562 /locus_tag="ClothDRAFT_2223" /note="Walker A/P-loop; other site" /db_xref="CDD:73014" misc_feature order(11548..11553,11557..11565,11695..11697,11923..11928, 12022..12024) /locus_tag="ClothDRAFT_2223" /note="ATP binding site; other site" /db_xref="CDD:73014" misc_feature 11686..11697 /locus_tag="ClothDRAFT_2223" /note="Q-loop/lid; other site" /db_xref="CDD:73014" misc_feature 11851..11880 /locus_tag="ClothDRAFT_2223" /note="ABC transporter signature motif; other site" /db_xref="CDD:73014" misc_feature 11911..11928 /locus_tag="ClothDRAFT_2223" /note="Walker B; other site" /db_xref="CDD:73014" misc_feature 11935..11946 /locus_tag="ClothDRAFT_2223" /note="D-loop; other site" /db_xref="CDD:73014" misc_feature 12010..12030 /locus_tag="ClothDRAFT_2223" /note="H-loop/switch region; other site" /db_xref="CDD:73014" gene 13240..13845 /locus_tag="ClothDRAFT_2224" CDS 13240..13845 /locus_tag="ClothDRAFT_2224" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430363.1" /db_xref="GI:256005399" /translation="MNLNYKMVGEHISNYAIGDSEEPLNFISFTKLMVESRTISFYHR SRTIGEVKGNAVVNWIFFIIDGLGSIFGSVMAYWLVLRDAKYCNDCKRYMKKKSILKF LATDIDRTIKFQDIDNLSSDEIKDLFLPTNVGKNEHYEIIVYWCQECDKGYLKMKYMG KNSKGKIEENLSKSKEFEISSYTVRTLCDLSRNGFRDKVVV" gene 14122..15156 /locus_tag="ClothDRAFT_2225" CDS 14122..15156 /locus_tag="ClothDRAFT_2225" /inference="protein motif:PFAM:PF08240" /note="PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: hypothetical protein ; K00008 L-iditol 2-dehydrogenase" /codon_start=1 /transl_table=11 /product="Alcohol dehydrogenase GroES domain protein" /protein_id="ZP_05430364.1" /db_xref="GI:256005400" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /translation="MLQSVMVSPGKIEFHEVEKPELKPGQVLIKIMRIGICGSDIHVN HGKHPFTKYPVTQGHEVSGKIVEVAEDVEHLKVGQKVTIEPQVVCGKCHPCRTGKYNL CEELKVMGFQTVGAGSEYFAVDAKNVTTVPDHLSYDEAAMIEPLAVTVHAANRVGDVK DKDIVVIGAGPIGILLVQTLKAKGARKVMVTDVSDYRLELALKCGADFAVNTKKEDFG EAMLRCFGPDKADVIYDCAGNNTTMEQAIKHSRKGSIIVLVAVFEGMATVDLATLNDK ELDLNTTMMYRHEDYVEAIELVEAGKVKLTPLMSKHFAFRDWEKAYEYIDNNREITMK VLIDVNNDDD" misc_feature 14122..15138 /locus_tag="ClothDRAFT_2225" /note="Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261" /db_xref="CDD:176222" misc_feature 14134..15135 /locus_tag="ClothDRAFT_2225" /note="Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063" /db_xref="CDD:31263" misc_feature order(14230..14238,14245..14247,14551..14553,14563..14565, 14623..14640,14695..14700,14710..14712,14755..14757, 14827..14832,14836..14838,14896..14901,14968..14976) /locus_tag="ClothDRAFT_2225" /note="putative NAD(P) binding site; other site" /db_xref="CDD:176222" misc_feature order(14230..14232,14296..14301,14551..14553) /locus_tag="ClothDRAFT_2225" /note="catalytic Zn binding site; other site" /db_xref="CDD:176222" misc_feature order(14386..14388,14395..14397,14404..14406,14428..14430) /locus_tag="ClothDRAFT_2225" /note="structural Zn binding site; other site" /db_xref="CDD:176222" gene 15194..16165 /locus_tag="ClothDRAFT_2226" CDS 15194..16165 /locus_tag="ClothDRAFT_2226" /inference="protein motif:PFAM:PF00294" /note="PFAM: PfkB domain protein; KEGG: hypothetical protein ; K00847 fructokinase" /codon_start=1 /transl_table=11 /product="PfkB domain protein" /protein_id="ZP_05430365.1" /db_xref="GI:256005401" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /translation="MFDVVAVGELLIDFLPAGTNENGMPLFSSNPGGAPANVLAMLSK LGAKTAFIGKVGKDGFGQFLKATLDNAGIDTSNLLMSSSEMTTLAFVHLNEKGDRSFS FYRKHCADVSLDAGELDKDLLRTCHFLHFGAVSLTDEPSRTATLEAARIAKEAGAIIS YDPNYRPALWSNEHEARKYMLKAVEYADLVKVSEEELWLLAESEDFSKGAHKLLAMGP SVVFVTCGEKGSYVFTGSCKANHCGYDVKVVDTTGAGDAFVGAMLWQLRGMSLEEISQ ICEQKWGELLAFSNAAGTIVATKKGAIPAMPDLDTINTFMRQFLEEK" misc_feature 15200..16102 /locus_tag="ClothDRAFT_2226" /note="Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167" /db_xref="CDD:29351" misc_feature order(15302..15304,15950..15952,15959..15961) /locus_tag="ClothDRAFT_2226" /note="putative substrate binding site; other site" /db_xref="CDD:29351" misc_feature order(15770..15772,15863..15865,15944..15946,15953..15958, 15965..15967) /locus_tag="ClothDRAFT_2226" /note="putative ATP binding site; other site" /db_xref="CDD:29351" gene 16221..17384 /locus_tag="ClothDRAFT_2227" CDS 16221..17384 /locus_tag="ClothDRAFT_2227" /inference="protein motif:PFAM:PF00480" /note="PFAM: ROK family protein; KEGG: scl:sce7667 ROK family transcriptional regulator" /codon_start=1 /transl_table=11 /product="ROK family protein" /protein_id="ZP_05430366.1" /db_xref="GI:256005402" /db_xref="InterPro:IPR000600" /translation="MDKFTKLDLNSITSNNRMNIFNCILEAKEINRAVIAKKVGLSIP AVMSITDDLIQKGIIYVIGKGKSSGGKRPELLAVVPDRFFFVGVDVGRTSVRVVVMNN CRDVVYKVSKPTESVEPDELINQITEMTMESINESKFPLDRVVGIGVAMPGLIERGTG RVIFSPNFGWNNIALQDELKKHLPFNVLVENANRALVIGEIKNTQPNPTSCIVGVNLG YGIGSAIVLPNGLYYGVSGTSGEIGHIIVENHGSYCSCGNYGCIESIASGEAIAREAR IAIANKIQSSVLEKCEGDLKKIDAKMVFDAAKEGDHLAQSIVEKAADYIGKGLAITIN MLDPEQIILCGGLTLSGDFFIDMIKKAVSKYQMLMPEEMLKLLLVKVDSMLLP" misc_feature 16536..17003 /locus_tag="ClothDRAFT_2227" /note="ROK family; Region: ROK; cl09121" /db_xref="CDD:186831" misc_feature <17118..17312 /locus_tag="ClothDRAFT_2227" /note="Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971" /db_xref="CDD:32790" gene 17751..19250 /locus_tag="ClothDRAFT_2228" CDS 17751..19250 /locus_tag="ClothDRAFT_2228" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sme:SM_b20503 putative sugar ABC transporter ATP-binding protein" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430367.1" /db_xref="GI:256005403" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /translation="MDNALLLEVKGLSKVFPGTRALNRVSLEVRKGEVHGLCGENGAG KSTLMNIVGGVFPATEGIMKFDGKIFNPKNPKDSQDAGIGFVHQELCLCPHLSAAENI FIGRLPSKGDKIDFKKLYEDADAILKTLDANFSSKTLVSNLTVSEQQLVEIAKSISLN CKLLILDEPTSSLTDKETARLFQVVRDLKKKGISILFISHRMKEVFEICDRVTVLKDG SYVCCMNISEITHEDVIRAMVGRDLGELYPPKSSKIEEDNYILKVENLSGNGFENVSF TLKKGEILGFAGLVGAGRSEVMRGLCAIDPVKRGEVYLNGEKQKFKRYKDAVKKGICY LTEDRKNSGLFLHMSIAQNISSANLEAVSKRGWIIKKREYSLSEKYVKALSIKIPGLS YPISNLSGGNQQKCLIGKWLSTNPKVIIMDEPTRGIDVGAKREIHNLLRSLSEQGVGV IIVSSELPEIIGVADRIAVMHEGRLAGFLQGEQVSEENIMKLASGANLS" misc_feature 17751..19238 /locus_tag="ClothDRAFT_2228" /note="ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129" /db_xref="CDD:31325" misc_feature 17769..18413 /locus_tag="ClothDRAFT_2228" /note="This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216" /db_xref="CDD:72975" misc_feature 17865..17888 /locus_tag="ClothDRAFT_2228" /note="Walker A/P-loop; other site" /db_xref="CDD:72975" misc_feature order(17874..17879,17883..17891,18012..18014,18249..18254, 18348..18350) /locus_tag="ClothDRAFT_2228" /note="ATP binding site; other site" /db_xref="CDD:72975" misc_feature 18003..18014 /locus_tag="ClothDRAFT_2228" /note="Q-loop/lid; other site" /db_xref="CDD:72975" misc_feature order(18036..18047,18189..18206) /locus_tag="ClothDRAFT_2228" /note="ABC transporter signature motif; other site" /db_xref="CDD:72975" misc_feature 18237..18254 /locus_tag="ClothDRAFT_2228" /note="Walker B; other site" /db_xref="CDD:72975" misc_feature 18261..18272 /locus_tag="ClothDRAFT_2228" /note="D-loop; other site" /db_xref="CDD:72975" misc_feature 18336..18356 /locus_tag="ClothDRAFT_2228" /note="H-loop/switch region; other site" /db_xref="CDD:72975" misc_feature 18528..19175 /locus_tag="ClothDRAFT_2228" /note="This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215" /db_xref="CDD:72974" gene 19262..20311 /locus_tag="ClothDRAFT_2229" CDS 19262..20311 /locus_tag="ClothDRAFT_2229" /inference="protein motif:PFAM:PF02653" /note="PFAM: inner-membrane translocator; KEGG: smd:Smed_3605 monosaccharide-transporting ATPase" /codon_start=1 /transl_table=11 /product="inner-membrane translocator" /protein_id="ZP_05430368.1" /db_xref="GI:256005404" /db_xref="InterPro:IPR001851" /translation="MKDKITGIIKKIFSQREVTVFLIILLVVAITSIIQPKFLNSNNM RSIALSVSVDGLFAIGLTMALILGGIELSVGSVAAMTCVITGYLALQGVNIGVACIAS IASGLVVGLFNGFMISKIGLPPFIVTLGMENLARGMAYIITTGSPLSVSGYLPQSFRF FATGSVFGIPVLFIIFIIISAIAFIFMKYSKICRNIYYVGSNENAARLSGINVDRVKI GVYVTIALISTLAGLLSLARFNVATPELSKGAETTAISAAVIGGTSMTGGSGGVLGTV LGIFLLKIVNSALVMMNVSVYWQEFVQGAILVLAVTIDYLSHRKNGGPSFIMKFFGLD KLASKKLDDKSSRQI" misc_feature 19412..20203 /locus_tag="ClothDRAFT_2229" /note="Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579" /db_xref="CDD:119321" misc_feature 19871..19927 /locus_tag="ClothDRAFT_2229" /note="TM-ABC transporter signature motif; other site" /db_xref="CDD:119321" gene 20391..21356 /locus_tag="ClothDRAFT_2230" CDS 20391..21356 /locus_tag="ClothDRAFT_2230" /inference="protein motif:COG:COG1879" /note="KEGG: oan:Oant_3072 putative ABC transporter periplasmic sugar-binding protein" /codon_start=1 /transl_table=11 /product="ABC-type sugar transport system periplasmic component-like protein" /protein_id="ZP_05430369.1" /db_xref="GI:256005405" /translation="MKRFLVLLLAISLIFTFTACNSGSGSGNGQAKGYVGDPSDEYYM VTFLSGIDYWKYCFEGFEDAAKAIGVTAKYTGQTDTDVSGQVAVLEQVIAQKPKGIAV TAVNSTALADTINSAIEQGISVVCFDSDSPTSNRSAYLGTGNYAAGQKAAEFLVPLVN YKGKIAVLYTVGAENSESRVQGFEDWCKQNAPEVSLVKVNDAGDTTVAADNLAAALQA NDDIVGVFCVDGVAGTAGPTAVAESKKDLRVLAFDVDVTVLDKVKSGEIDGTVAQGMY NMGYWSLMMLYTEANGLSSKALPGNLDTGVVIVTKDNVDEYYPKK" sig_peptide 20391..20486 /locus_tag="ClothDRAFT_2230" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.317 at residue 32" misc_feature 20514..21314 /locus_tag="ClothDRAFT_2230" /note="Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536" /db_xref="CDD:107249" misc_feature order(20547..20549,20772..20774,20925..20927,21147..21149, 21207..21209) /locus_tag="ClothDRAFT_2230" /note="ligand binding site; other site" /db_xref="CDD:107249" gene 21394..22563 /locus_tag="ClothDRAFT_2231" CDS 21394..22563 /locus_tag="ClothDRAFT_2231" /inference="protein motif:PFAM:PF00465" /note="PFAM: iron-containing alcohol dehydrogenase; KEGG: vsp:VS_0171 putative alcohol dehydrogenase" /codon_start=1 /transl_table=11 /product="iron-containing alcohol dehydrogenase" /protein_id="ZP_05430370.1" /db_xref="GI:256005406" /db_xref="InterPro:IPR001670" /translation="MKAFNYYAPTEIIFGCGRVQEIGSITAQYGKKALLVTVPEFPEV KELYEKVKKSLRENGVEVVHFDGVIPNPTTDVVTEGANMAKAAGVDVVIGLGGGSSID TAKAIAVEATHPGTAWDYNCHTPGPTSATLPIIAIGTTAGTGSQCTQCAVITKTSEKD KSAIWHKNIFPKVAIVDPEVTVTMPKSVTAQTGFDAFAHNFEAYLSVKTSPLVEMMAI EAIKMIKEYLPKALENPNDIEARSKMSLADTLGGLTNSNAGVTLPHGLGMQVGGHAPH VSHGQALAIIYPQFTRYTYAWAIEKFAKVGRIFNPALNELSDEEAAKEACVAIDDFLK KIGLWIGFKDVNVTKEQIREIADDGQVLGDYLNNPRVATIDEMYELLMNCYERKE" misc_feature 21403..22548 /locus_tag="ClothDRAFT_2231" /note="Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454" /db_xref="CDD:31643" misc_feature 21409..22530 /locus_tag="ClothDRAFT_2231" /note="Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185" /db_xref="CDD:173944" misc_feature order(21505..21507,21682..21690,21697..21699,21706..21708, 21808..21813,21817..21819,21874..21879,21931..21933, 21955..21957,21976..21978,21988..21990,22183..22185, 22195..22197,22228..22230) /locus_tag="ClothDRAFT_2231" /note="putative active site; other site" /db_xref="CDD:173944" misc_feature order(21976..21978,21988..21990,22183..22185,22228..22230) /locus_tag="ClothDRAFT_2231" /note="metal-binding site" /db_xref="CDD:173944" gene 22577..23002 /locus_tag="ClothDRAFT_2232" CDS 22577..23002 /locus_tag="ClothDRAFT_2232" /inference="protein motif:PFAM:PF05025" /note="PFAM: RbsD or FucU transport; KEGG: ypi:YpsIP31758_0348 RbsD/FucU family transport protein" /codon_start=1 /transl_table=11 /product="RbsD or FucU transport" /protein_id="ZP_05430371.1" /db_xref="GI:256005407" /db_xref="InterPro:IPR007721" /translation="MVETGILNRDIAAELAKLGHTDRVLIADAGLAIPNTTKVIDVSL DVNFPTTVDVLKVLLKHFSVEKLILSQATVDVSPSRYKEYLSLFDESVPCEIVEHSTL RDTLTKEVKFAIRTGDFTANSNIILVSAGGPRWYCENLE" misc_feature 22577..22963 /locus_tag="ClothDRAFT_2232" /note="RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809" /db_xref="CDD:186199" gene 23429..25153 /locus_tag="ClothDRAFT_2233" CDS 23429..25153 /locus_tag="ClothDRAFT_2233" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase; KEGG: scl:sce5644 carbohydrate ABC transporter" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430372.1" /db_xref="GI:256005408" /db_xref="InterPro:IPR001140" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017940" /translation="MKKLSVYLKGYIKESILGPLFKLLEASFELLVPIVIKSIVDTGI GRADKVYIIKMCLLLILLGVVGMVCSVTAQYFAAKASVGFVTKLRRALFRHIGQLSYT EIDTLGTSSMITRMTSDINQVQTGMNLTLRLLLRSPFIVFGAMIMAFTVDTNAAFTFV VAIPALFIVVFAIMLLSIPLYRKVQQRLDRVLKSTRENLTGVRVIRAFRLEEKEIAEF DKRNEELTSTQIFVGRISALMNPLTYVIINLAIIWLIHIGAIRVSKGLLTQGAVLALY NYMSQILTELIKFANLIISITKAVASANRISAVLDVESSLVEKESEPQGDRSEFIVEF HNVGLTYKNAGAEALTNINFSVRRGEVVGIIGGTGSGKTSLVNLIPRFYDATVGEVIV DGINVKDYPLKKLRDKIGVVPQKAVLFKGSIRENMRWGNKNATDEEIMEAINIAQAGE IVAQKKEGLDFLIEQGGKNLSGGQRQRFTIARAIVKKPEILILDDSASALDFATDAAL RKALRELPWNPTIFIVSQRTSSIQHADKIIVLDDGEIVGIGKHDELLETCEVYREIYD SQFKKEEK" misc_feature 23429..25141 /locus_tag="ClothDRAFT_2233" /note="ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132" /db_xref="CDD:31327" misc_feature 23474..24277 /locus_tag="ClothDRAFT_2233" /note="ABC transporter transmembrane region; Region: ABC_membrane; cl00549" /db_xref="CDD:186074" misc_feature 24422..25123 /locus_tag="ClothDRAFT_2233" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" misc_feature 24524..24547 /locus_tag="ClothDRAFT_2233" /note="Walker A/P-loop; other site" /db_xref="CDD:72971" misc_feature order(24533..24538,24542..24550,24668..24670,24908..24913, 25004..25006) /locus_tag="ClothDRAFT_2233" /note="ATP binding site; other site" /db_xref="CDD:72971" misc_feature 24659..24670 /locus_tag="ClothDRAFT_2233" /note="Q-loop/lid; other site" /db_xref="CDD:72971" misc_feature 24836..24865 /locus_tag="ClothDRAFT_2233" /note="ABC transporter signature motif; other site" /db_xref="CDD:72971" misc_feature 24896..24913 /locus_tag="ClothDRAFT_2233" /note="Walker B; other site" /db_xref="CDD:72971" misc_feature 24920..24931 /locus_tag="ClothDRAFT_2233" /note="D-loop; other site" /db_xref="CDD:72971" misc_feature 24992..25012 /locus_tag="ClothDRAFT_2233" /note="H-loop/switch region; other site" /db_xref="CDD:72971" gene 25155..26915 /locus_tag="ClothDRAFT_2234" CDS 25155..26915 /locus_tag="ClothDRAFT_2234" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase; KEGG: scl:sce5645 carbohydrate ABC transporter" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430373.1" /db_xref="GI:256005409" /db_xref="InterPro:IPR001140" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017940" /translation="MKSRKIQMDTIRKVLRYIKKYRVLLFISILLAASTVALTLYVPI LIGNAIDYIVGPGNVNFEVVAKILVQIAFAVGITAIFEWFMYTINNNITYQVVRDIRE KAFRKIEILPLSYIDSHPHGEIVSRVIADVEQFAEGLLMGFTQLFTGVVTIIATLIFM LTINIKITFIVVILTPLSLFVANFIAKHTYSMFKLQSETRGEQTSLIEEMIGNVKVVQ AFSYQEEALKKFDEINERLEKYSLRAVFFSSLTNPLTRFINSLVYAAVALAGAIAVIS GDVGSTMTVGGLSIFLSYASQYAKPFNEISGVITEMQNALACAGRVFELIEEKPQVPD ADDAVTLKNASGNVVFDNVAFSYVPERPLIRNLNLEVKPGQRVAIVGPTGSGKTTVIN LLMRFYDVDSGSIKVEGIDIRNITRQSLRENYGMVLQDTWLKSGTIRENITMGKPDAT EEEIIAAAKAAHAHSFIKRLENGYDTVISEEGGSLSQGQKQLLSIARVMLCLPPMLIL DEATSSIDTRTEVKIQEAFARLMQGRTSFVVAHRLSTIREADVILVMKDGDIIEQGTH EELLSKKGFYANLYNSQFAQ" sig_peptide 25155..25268 /locus_tag="ClothDRAFT_2234" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.811 at residue 38" misc_feature 25176..26912 /locus_tag="ClothDRAFT_2234" /note="ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132" /db_xref="CDD:31327" misc_feature 25227..26060 /locus_tag="ClothDRAFT_2234" /note="ABC transporter transmembrane region; Region: ABC_membrane; cl00549" /db_xref="CDD:186074" misc_feature 26190..26876 /locus_tag="ClothDRAFT_2234" /note="Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254" /db_xref="CDD:73013" misc_feature 26295..26318 /locus_tag="ClothDRAFT_2234" /note="Walker A/P-loop; other site" /db_xref="CDD:73013" misc_feature order(26304..26309,26313..26321,26439..26441,26679..26684, 26775..26777) /locus_tag="ClothDRAFT_2234" /note="ATP binding site; other site" /db_xref="CDD:73013" misc_feature 26430..26441 /locus_tag="ClothDRAFT_2234" /note="Q-loop/lid; other site" /db_xref="CDD:73013" misc_feature 26607..26636 /locus_tag="ClothDRAFT_2234" /note="ABC transporter signature motif; other site" /db_xref="CDD:73013" misc_feature 26667..26684 /locus_tag="ClothDRAFT_2234" /note="Walker B; other site" /db_xref="CDD:73013" misc_feature 26691..26702 /locus_tag="ClothDRAFT_2234" /note="D-loop; other site" /db_xref="CDD:73013" misc_feature 26763..26783 /locus_tag="ClothDRAFT_2234" /note="H-loop/switch region; other site" /db_xref="CDD:73013" gene 27053..27373 /locus_tag="ClothDRAFT_2235" CDS 27053..27373 /locus_tag="ClothDRAFT_2235" /inference="protein motif:PFAM:PF01906" /note="PFAM: protein of unknown function DUF74; KEGG: vsp:VS_II0425 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF74" /protein_id="ZP_05430374.1" /db_xref="GI:256005410" /db_xref="InterPro:IPR002765" /translation="MIITTTNGIEGKRVVEYKGIVCGEVISGVDFIKDFAAGLTNFFG GRSKSYEGELIEAREGAIREMKERAIQMGANAIIGVDIDYEVLGQGGNMLMVTASGTA VVIE" misc_feature 27053..27370 /locus_tag="ClothDRAFT_2235" /note="Domain of unknown function (DUF74); Region: DUF74; cl00426" /db_xref="CDD:185989" gene complement(27513..28340) /locus_tag="ClothDRAFT_2236" CDS complement(27513..28340) /locus_tag="ClothDRAFT_2236" /inference="protein motif:PFAM:PF04536" /note="PFAM: protein of unknown function DUF477; KEGG: ecz:ECS88_3043 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF477" /protein_id="ZP_05430375.1" /db_xref="GI:256005411" /db_xref="InterPro:IPR007621" /translation="MRKKSSISALILLSFFFISYISQALVFAESSKNVKDYLNYLTAE EIASLQSDIDSIKKSYKLDVVIVITDNTQGKSSRDFADDFYDYNGYGIGTRKSGLLML VNMQNREIWISTCGDAIDIFTDNRISIMEDNVIRHLSNNDYYSACKTFIRDVKNYAYD GVPYGQYRSQSDTNITYADKVSRRIKSVSIYITALVISLGATLILSLSSKGKITINSG TYEEPGSFVLTETRDDYIRESTTRTRISESSGSRGGNVSSTHTGSSGRTHGGGGKKF" sig_peptide complement(28254..28340) /locus_tag="ClothDRAFT_2236" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.715 at residue 29" misc_feature complement(27870..28226) /locus_tag="ClothDRAFT_2236" /note="Domain of unknown function (DUF477); Region: DUF477; cl01535" /db_xref="CDD:154459" gene complement(28333..29361) /locus_tag="ClothDRAFT_2237" CDS complement(28333..29361) /locus_tag="ClothDRAFT_2237" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: dal:Dalk_2532 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430376.1" /db_xref="GI:256005412" /translation="MTSVKEYKCPSCGAGLDFDPPSQKWKCNYCFNEYEKDQFDISDN EELLNEEMPELDSYICNSCGAELIADNTTSATFCIYCKSPAVIKSRFSGRFRPRNVIP FRLTKEQAKEIYQKWIKKRIFAPKEFKLKEEVDKITGIYAPFWLFDCKADGFISGEAT RVHSWRQGNYKYTQTKYYSILRRGHARYKRIPVDASKKLDDKYMHMIEPFDYKDLKDF SMKYMSGFMAERYDVESAEAVTILKDRVKDYLSERLRGTVSGYSSCSITSKNINISEI EQSYSMLPVYLLVNKYKDKSHIFMINGQTGKVVGDTPLCLPKQILFAVAVFLLVWIIG VFGGALFA" gene 30031..32298 /locus_tag="ClothDRAFT_2238" CDS 30031..32298 /locus_tag="ClothDRAFT_2238" /inference="protein motif:PFAM:PF00672" /note="PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; SMART: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: sat:SYN_01236 methyl-accepting chemotaxis protein" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis sensory transducer" /protein_id="ZP_05430377.1" /db_xref="GI:256005413" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /translation="MKNRFNIREVFSKIKTSGFKKIKRLKQAIASKVRFLKSLNEKKS SEKNIFMPFFRLKDVSIGIKLNVIVSIVLVVSLSVVILYSFGIVRNILVEQAKDGTLQ VSKQTNSNMRMLLESMDQEATALSRNEQIADIISRLNSTDDATLQSRYSSQLRTMLTN YVDEKSNYFYTILAVSNNYLYSISGQQIISHQINIKEVDSIKSFVESTKYSKWYDPYV QDVLIHQDTTGLGGKVITLAKKVYSRTKLKSPGQLFFYINYENLGRIFNDLHLPYDGV MYVVGNDYNIVMNPSKKEHMSLAINDVSQEEKERNFYIDEEIFKKIKSEPSGAFTTKL YGKDVLITFSTIDKVNVTDLGWTFVTVTEVDKITESVNRVSAQVIIIGLICLALGILL SQLINKDITKNIKKLVKTMEKVGSGNLSIEFKVEERKDEIGKLSNSFAKMISNLNGLI MSVKHASDVTIDASSNVSAKIQETYASIQQTNAILDVIKEKSFQQGKIVKEGERQVAL TKDEVNQAKDTMKDVDAILSKSKEISEDNRMSVSLLHEMSQNIRTAMNEIGAESKELI ATSKEITKFTRQIKEISEQTKLIALNSAIESARLGAQGKTFHLLSEETRNLASKTKDL SGSIDQIIQNLIEKINNTNKVVLKLDKVAENTENSVKDVTESLDKNIEFLNEITSNVS RIKQVFTHIDDFVNQIVSTIEYISASAEANIQDISDVSKAMNEQIKCQESLLEQTTNL LNLSQELKKKAEEIS" misc_feature <31228..31371 /locus_tag="ClothDRAFT_2238" /note="Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054" /db_xref="CDD:154171" misc_feature 31660..32253 /locus_tag="ClothDRAFT_2238" /note="Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144" /db_xref="CDD:153541" gene 32555..34753 /locus_tag="ClothDRAFT_2239" CDS 32555..34753 /locus_tag="ClothDRAFT_2239" /inference="protein motif:PFAM:PF07833" /note="PFAM: copper amine oxidase domain protein; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="copper amine oxidase domain protein" /protein_id="ZP_05430378.1" /db_xref="GI:256005414" /db_xref="InterPro:IPR012854" /translation="MFKACLAKTMGRVLTFLAFLTVISIGAFCSYAADTAQTDSRTVV TSDFIDLKFTINKKNYISKTVSKDLEVAPFISNGRTLVPFRAIFEELGYTVDWNDATK TVTAKYKGNEIKLTVGANKAVVNGYEVPLDVAPAIVNSRTVVPLRFVAENSGSFVDWN PEDKTISIKRIGKFNTGTILFYDQKGKNPMVYVYDGQTISSISLKGNEIKNAITYNGG LLITLFDVENDTNNLVTYRNGKLEVLISNFEIKGQVEFNGNLLLHGYDRRQKKDSLYR FDGKNIYLIADNFAMGHYVIFNDKLVINKYDDLRRYSLLVFDKSSWNPKVLRDGFIIR ETLIEDNVLFISGDSSVGNTKPFISYDGTKVQVLSEDLDIDLKKTVQFKDKDGINNIV TVAKKGSTGYFLVLRNSIKEPTEYTIYDLFAPTSIFQSAGVKPSAVKVDGIVDYNGKI FIAVNQTKSIITAKSFRTTDVPSYIKRENLFTYPNTRCLVLSDVETIHSGVTFLNFII EDDNLLMHLQNKDTKDYLLHIYDKDKVSTAHDVVKINNIITVGQRTFIAVEDIDRITE KKRQALLIYDQNVSSPNLRIRNLVLGMETKAWDELNGSLAISGNEADIKRNKVYLYSN EFKELLSNFQVNYWEKIGDLIFTSGVDTDTKVDSFHCINSRNSELLRDYFDVDKVVKA KGDYYIVYGIEKAPKTKYTNKKILYIYNFRTKEFVDLVVDFQLTDILFIN" sig_peptide 32555..32653 /locus_tag="ClothDRAFT_2239" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 at residue 33" misc_feature <32669..32869 /locus_tag="ClothDRAFT_2239" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" misc_feature 32783..33058 /locus_tag="ClothDRAFT_2239" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" misc_feature 32966..>33154 /locus_tag="ClothDRAFT_2239" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" gene 34976..35737 /locus_tag="ClothDRAFT_2240" CDS 34976..35737 /locus_tag="ClothDRAFT_2240" /inference="protein motif:TFAM:TIGR02895" /note="TIGRFAM: RNA polymerase sigma-I factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; KEGG: chromosome associated protein ; K06669 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)" /codon_start=1 /transl_table=11 /product="RNA polymerase, sigma 28 subunit, SigI" /protein_id="ZP_05430379.1" /db_xref="GI:256005415" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /translation="MFEPNLIYGVKKREKKSRSDSINHIIIKIKNGDIELKEKFIKKY KPYLLKIISSTLGRYVDPEVSEEYSVGLMAFNEAIDGFNPEINGNFTNYCNMVVNHRI IDYIRKNKKYSNVIPFSYFEERNDFEEKYLVSDSHYLYENIEVKEEILQFEQQLKQFG ITLEDLVMNSPKHKDSRELCISIARILSENDKLFEKMIRKKCIPLSELMGLVNVHRKT VERNRKFIIAVSLILRSGLDEIKQFFRASEERREK" misc_feature 35027..35731 /locus_tag="ClothDRAFT_2240" /note="putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311" /db_xref="CDD:181376" misc_feature 35135..35308 /locus_tag="ClothDRAFT_2240" /note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542" /db_xref="CDD:146937" gene 35737..37305 /locus_tag="ClothDRAFT_2241" CDS 35737..37305 /locus_tag="ClothDRAFT_2241" /inference="protein motif:PFAM:PF00942" /note="PFAM: type 3a cellulose-binding domain protein; KEGG: eca:ECA1981 endoglucanase V" /codon_start=1 /transl_table=11 /product="type 3a cellulose-binding domain protein" /protein_id="ZP_05430380.1" /db_xref="GI:256005416" /db_xref="InterPro:IPR001956" /translation="MNLGVVIKIKRKKAIIVTETGEFKAVNARNGMFLGQKILFDQQD VIENNRNGIGLAYSAAIAGMVAVFVFMFTYFGLHNFNGTFAYVDVDINPSVEFAVNRD GIVVNAEPLNDDGRKVLEELIYKDALLEDVILDLVDKSRKYGFIEDNDRKNIILISAA LNSDEQEQRNDFEKKLVDNLMPELENLDVNIEMRFVIASKEQRKKAQENKVSMGKYMI YEMARRQGEKLTLESIMSETLENLLLGQDFGVIETEKTPVNTPVKSTATPTKALAAEI TPTKTPEQVVMTPANTPAKPTAAPTKAPAAVAVTSAKTPERATTVPVNTPVKPTDAPT KSPATATATATRAPVKATATPAKTLKPSDTPVKTPDGEQSVKVRFYNNNTLSETGVIY MRINVINTGNAPLDLSDLKLRYYYTIDSESEQRFNCDWSSIGAHNVTGSFGKVNPSRN GADTYVEIGFTKEAGMLQPGESVELNARFSKTDNTQYNKADDYSFNSHYYEYVDWDRI TAYISGILKWGREP" misc_feature 36865..37113 /locus_tag="ClothDRAFT_2241" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" gene 37388..38968 /locus_tag="ClothDRAFT_2242" CDS 37388..38968 /locus_tag="ClothDRAFT_2242" /inference="protein motif:PFAM:PF00150" /note="PFAM: glycoside hydrolase family 5; cellulosome protein dockerin type I; KEGG: azc:AZC_1301 endoglucanase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 5" /protein_id="ZP_05430381.1" /db_xref="GI:256005417" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MRKVKALLLGLIVLAVALLPTVSFKSPTVAADPNNDDWLHVEGN KIVDMYGNQVWLTGCNWFGFNTGTNVFDGVWSCNMREALKGMADRGINFLRIPISTEL LYQWSQGIYPKANVNDFVNPELKGKNSLELFDFAVQCCKEFGIKIMVDIHSPATDAMG HMYPLWYDGQFTTEIWISTLEWLTERYKNDDTILALDLKNEPHGTPGSELMAKWDGST DLNNWKHAAETCAKRILAINPNILIVVEGVEVYPKPGYDYTAVDEWGKESKYFYNWWG GNLRGVRDYPIDLGKHQKQLVYSPHDYGPLVHKQPWFYEGFNKETLYNDCWRDNWAYI HEENIAPLIVGEWGGFMDRGDNEKWMKALRDYMIENKISHTFWCYNANSGDTGGLVYY DFITWDEEKYALLKPALWQTEDGKFIGLDHQIPLGSNGITVTEYYGGYIPEPSPTATV PDVPTPSHSFEIEKGDVNGDGNVNSTDVVWLRRFLLKLVEDFPVPSGKQAADMNDDGN INSTDMIALKRKVLKIPI" sig_peptide 37388..37480 /locus_tag="ClothDRAFT_2242" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.537 at residue 31" misc_feature 37520..38548 /locus_tag="ClothDRAFT_2242" /note="Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl12144" /db_xref="CDD:159804" misc_feature 38783..38845 /locus_tag="ClothDRAFT_2242" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene complement(38994..39731) /locus_tag="ClothDRAFT_2243" CDS complement(38994..39731) /locus_tag="ClothDRAFT_2243" /inference="similar to AA sequence:KEGG:Gmet_0125" /note="KEGG: gme:Gmet_0125 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430382.1" /db_xref="GI:256005418" /translation="MIHYYYDGTFDGLLTCVYESYYGVEPPDRIFRSKNMQQSILDKN IDIVTDSEKASKVYEAICEKISYDALRNVYHAYLSELDNIDTYILRYLRIGFKKGKSV DLYLTSEEVLKVHSAAKKVRTESHLMLGLLRFKKLKGGLYYAPYSPVYNITVLISDHF VRRLSDQFWIIHDTKRNFAAVYNTSKCVFTDLPAELQYQSAKTDDQFEELWKNYFNSI CIKDRVNPKLQKQNMPQKYWKYLVEKQ" gene complement(39761..41068) /locus_tag="ClothDRAFT_2244" CDS complement(39761..41068) /locus_tag="ClothDRAFT_2244" /inference="similar to AA sequence:KEGG:GSU3329" /note="KEGG: gsu:GSU3329 radical SAM domain-containing protein" /codon_start=1 /transl_table=11 /product="radical SAM domain-containing protein" /protein_id="ZP_05430383.1" /db_xref="GI:256005419" /translation="MELQKKLEILSAAAKYDVSCSSSGSNRKNTKGGLGNAASFGICH SWSDDGRCISLLKILLTNYCVYDCAYCVNRVSNDIPRAAFTPQEVANLTINFYRRNYI EGLFLSSAVVKNPNHTMELLYESLRILRKEYRFNGYIHVKAIPGADLGLIEAVGKLAD RMSVNIELPSENGLKLLAPQKNKQAILKPMNFIASKITEKRDERKVFKNAPLFVPGGQ STQLIVGATQDHDINILRLSENLYKKYKLKRVYYSAYVPVSKNPLLPDLKTPPLLREH RLYQADWLLRFYGFSADELLDERNPDFDPKLDPKTNWAINNMSLFPVEINRADYEMLL RVPGIGVRSAKKIIMARKVKSLSFEDLKKLGVVLKRAKFFITCNGKYFFNCNLDQNLI RQNLINGFEDNEKRQEWEQISIFSLIPEKPTLQDQIMSITGEI" misc_feature complement(39932..41068) /locus_tag="ClothDRAFT_2244" /note="Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277" /db_xref="CDD:33999" misc_feature complement(<40505..40897) /locus_tag="ClothDRAFT_2244" /note="Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056" /db_xref="CDD:187212" gene 41358..43946 /locus_tag="ClothDRAFT_2245" CDS 41358..43946 /locus_tag="ClothDRAFT_2245" /inference="protein motif:TFAM:TIGR00254" /note="KEGG: gur:Gura_0876 response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; GGDEF domain containing protein; extracellular solute-binding protein family 3; PAS fold-4 domain protein; PAS fold domain protein; SMART: EAL domain protein; GGDEF domain containing protein; extracellular solute-binding protein family 3; PAS domain containing protein" /codon_start=1 /transl_table=11 /product="diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s)" /protein_id="ZP_05430384.1" /db_xref="GI:256005420" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR013656" /db_xref="InterPro:IPR013767" /translation="MKVKCFGINLCVFSLLLIFCQVVYAKTDTIIYETELYGPPFKFI EDGEISGFEIELNQYIFSGSEYRFDYRFNTWEKVYEKLKNGEIDTCGLLVVNEERKKD ILFSDTVMNIYISIYSKEKNKNIGIKDLEKYRVGVGKEQYSEHILKDSVGISNYTTFV DVEEAIDALNEGKIDVIFENQDVVNHYLIKKGLTGKIIPHKTELFPVKVAYGVSKRNP ELVKYINERLDSVKKNGIYEQLYRKHFLRPSDFYRRKQRIRNFAAMLALLVLLALLQV YIRHLKKKISKAYRELRKQHEWLRITLSSIGEAVITTDENGTVTFSNYEIQKMLGLSE EEILGKKLDKLLSGLVDKREKVYKIPIEEVVNRGSMIKLETDLSLVTPGGRRLVEGTV APIRNDSDVIIGTVVALKDITEIKKKDEILYNMEYYDPLTGLPNRSLFSDRLKMALAQ SKRNNEMCALIILDLDNFKAINDTLGHSVGDMLLKQVAEKIKGYLREVDTVARIGGDE FIIIQPQIKDINDATRAADRILKKFQQPWILEGKEYYITASMGIGIYPNDGEDPQTIF KNADTALYRAKELGRNNYQLYTESMNQKVLQRLDIENSLRRAIEKEEFVLFYQPQIDI KTGKIVGFEALLRWYHPDYGLMPPMEFIPVAEDSGLIVVIGEWVLETACRQNKKWIEC GLEPHLISVNLSARQFQRSNIVEVIDRIRSSTGLAPELLELEITESTAMQDLSFTIDV LNQLRKKGIRVSLDDFGTGYSSLNYLRQLPIDTLKIDKSFVQDIRANSKEEAIAKTVI SLAHKLDLTVVAEGVETKEQLLFLKKEKCDKAQGYLFSKPLPAEEIEKMLRDKKCFVI GEEVDN" sig_peptide 41358..41435 /locus_tag="ClothDRAFT_2245" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 at residue 26" misc_feature 41457..42092 /locus_tag="ClothDRAFT_2245" /note="Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134" /db_xref="CDD:29040" misc_feature 41457..42092 /locus_tag="ClothDRAFT_2245" /note="Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497" /db_xref="CDD:144186" misc_feature order(41469..41471,41580..41582,41652..41654,41781..41783, 41895..41897) /locus_tag="ClothDRAFT_2245" /note="substrate binding pocket; other site" /db_xref="CDD:29040" misc_feature order(41844..41846,41856..41858,41874..41876) /locus_tag="ClothDRAFT_2245" /note="membrane-bound complex binding site; other site" /db_xref="CDD:29040" misc_feature 41970..41987 /locus_tag="ClothDRAFT_2245" /note="hinge residues; other site" /db_xref="CDD:29040" misc_feature 42246..>42368 /locus_tag="ClothDRAFT_2245" /note="PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459" /db_xref="CDD:141436" misc_feature 42264..42563 /locus_tag="ClothDRAFT_2245" /note="PAS fold; Region: PAS; pfam00989" /db_xref="CDD:144544" misc_feature 42636..43112 /locus_tag="ClothDRAFT_2245" /note="Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949" /db_xref="CDD:143635" misc_feature order(42747..42749,42876..42878) /locus_tag="ClothDRAFT_2245" /note="metal-binding site" /db_xref="CDD:143635" misc_feature order(42762..42764,42771..42776,42786..42788,42798..42800, 42864..42866,42870..42881) /locus_tag="ClothDRAFT_2245" /note="active site" /db_xref="CDD:143635" misc_feature order(42852..42854,42939..42941) /locus_tag="ClothDRAFT_2245" /note="I-site; other site" /db_xref="CDD:143635" misc_feature 43164..43886 /locus_tag="ClothDRAFT_2245" /note="EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948" /db_xref="CDD:30163" gene 44013..44282 /locus_tag="ClothDRAFT_2246" CDS 44013..44282 /locus_tag="ClothDRAFT_2246" /inference="protein motif:PFAM:PF01842" /note="PFAM: amino acid-binding ACT domain protein; KEGG: apa:APP7_1552 hypothetical protein" /codon_start=1 /transl_table=11 /product="ACT domain-containing protein" /protein_id="ZP_05430385.1" /db_xref="GI:256005421" /db_xref="InterPro:IPR002912" /translation="MRAVITVIGKDKIGIIAGISNILADCNVNILDISQTIMQDVFTM VMLVDISKLCVQFAELADRLEKKGVEMGLSVRIQHEDIFNSMHRI" misc_feature 44016..44279 /locus_tag="ClothDRAFT_2246" /note="ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872" /db_xref="CDD:153144" gene 44297..45655 /locus_tag="ClothDRAFT_2247" CDS 44297..45655 /locus_tag="ClothDRAFT_2247" /inference="protein motif:PFAM:PF05167" /note="PFAM: protein of unknown function DUF711; KEGG: pca:Pcar_2119 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF711" /protein_id="ZP_05430386.1" /db_xref="GI:256005422" /db_xref="InterPro:IPR007841" /translation="MLMPFEIMETIKMIQEENLDIRTITMGISLRDCASSNSKETRDK IYNKITRLAANLVKVGEDIEKEFGIPIVNKRISVTPISLVAESSDEENYIKFAETLDK AADAVGVNFIGGFSALVQKGYTIGDRRLIASIPEALSSTKKVCSSVNVASTKAGINMD AVREMGHVIKKAAELSADSGGLACAKLVVFANVPEDNPFMAGAFHGVGEPECVINVGV SGPGVVKSALEKVRGADFETVSETIKKTAFKITRMGQLVAREASRRLGVAFGIVDLSL APTPTIGDSVAHILEEMGLEKCGTHGTTAALALLNDAVKKGGTMASSSVGGLSGAFIP VSEDAGMIDAVKAGALSIEKLEAMTCVCSVGLDMIVVPGDTSEETISAIIADEAAIGV INNKTTAVRIIPAPGKKVGDIVEFGGLLGSGPVMKVSNFSSRDFINRGGRIPAPLNSL RN" misc_feature 44312..45514 /locus_tag="ClothDRAFT_2247" /note="Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025" /db_xref="CDD:153090" gene complement(45826..46860) /locus_tag="ClothDRAFT_2248" CDS complement(45826..46860) /locus_tag="ClothDRAFT_2248" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430387.1" /db_xref="GI:256005423" /translation="MGNKKDINLLPEEYRFASSRPSSDKRKDDGGIKEVGNSIKGLMD IISSKVSSLQNEKVKGFNSNTTKSLKNNISESISQNSEKPSGLPYSLKRARLRNLEDI LNLSKKDLVVSSKFNYVYCTDFGKVVIIDKDSQGQPKTVTIKEADNISVKTIKFHNAH PFLYPKYNESSLPEQIIYMDKNEIWYLADSEAIIVTFKNDTPDVLKISLANLKQNNNL KVVLNYIGCHKFLYQNKKLQTILLEERKIKTEDIIRVQDHYALYKEGNDSYRVLLFDE LKNISNEFTLTELPNVNEEAWDVLFTNDIFQYVQENGYSFSNFRQDNDYIEYWQNIGS KSVCVMRCKI" gene 47785..50472 /locus_tag="ClothDRAFT_2249" CDS 47785..50472 /locus_tag="ClothDRAFT_2249" /inference="protein motif:PFAM:PF00759" /note="PFAM: glycoside hydrolase family 9; glycoside hydrolase family 9 domain protein Ig domain protein; Carbohydrate-binding CenC domain protein; cellulosome protein dockerin type I; KEGG: scl:sce2234 cellulase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 9" /protein_id="ZP_05430388.1" /db_xref="GI:256005424" /db_xref="InterPro:IPR001701" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /db_xref="InterPro:IPR003305" /db_xref="InterPro:IPR004197" /translation="MNFRRMLCAAIVLTIVLSIMLPSTVFALEDKSPKLPDYKNDLLY ERTFDEGLCFPWHTCEDSGGKCDFAVVDVPGEPGNKAFRLTVIDKGQNKWSVQMRHRG ITLEQGHTYTVRFTIWSDKSCRVYAKIGQMGEPYTEYWNNNWNPFNLTPGQKLTVEQN FTMNYPTDDTCEFTFHLGGELAAGTPYYVYLDDVSLYDPRFVKPVEYVLPQPDVRVNQ VGYLPFAKKYATVVSSSTSPLKWQLLNSANQVVLEGNTIPKGLDKDSQDYVHWIDFSN FKTEGKGYYFKLPTVNSDTNYSHPFDISADIYSKMKFDALAFFYHKRSGIPIEMPYAG GEQWTRPAGHIGVAPNKGDTNVPTWPQDDEYAGRPQKYYTKDVTGGWYDAGDHGKYVV NGGIAVWTLMNMYERAKIRGIANQGAYKDGGMNIPERNNGYPDILDEARWEIEFFMKM QVTEREDASIAGMVHHKIHDFRWTALGMLPHEDPQERYLRPVSTAATLNFAATLAQSA RLWKDYDPTFAAQCLEKAEIAWKAALKNPDIYAEYTPGSGGPGGGPYNDDYVGDEFYW AACELYVTTGKDEYKNYLMNSPHYLEMPAKMGENGGANGEDSGLWGCFTWGTTQGLGT ITLALVENGLPSADIQKARNNIAKAADKWLENIEEQGYRLPIKQAEDERGGYPWGSNS FILNQMIVMGYAYDFTGNSKYLDGMQDGMSYLLGRNGLDQSYVTGYGERPLQNPHDRF WTPQTSKKFPAPPPGIIAGGPNSRFEDPTITAAVKKDTPPQKCYIDHTDSWSTNEITI NWNAPFAWVTAYLDEIDLITPPGGVDPEEPEVIYGDCNGDGKVNSTDAVALKRYILRS GISINTDNADVNADGRVNSTDLAILKRYILKEIDVLPHK" sig_peptide 47785..47868 /locus_tag="ClothDRAFT_2249" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 at residue 28" misc_feature 47902..48318 /locus_tag="ClothDRAFT_2249" /note="Carbohydrate binding domain; Region: CBM_4_9; pfam02018" /db_xref="CDD:145283" misc_feature 48421..48693 /locus_tag="ClothDRAFT_2249" /note="Cellulase N-terminus domain. Cellulases are O-glycosyl hydrolases (GHs) that hydrolyze beta 1-4 glucosidic bonds in cellulose. They are usually catagorized into either exoglucanases which sequentially release sugar units from the cellulose chain and...; Region: Cellulase_N_term; cd02850" /db_xref="CDD:30337" misc_feature 48706..50211 /locus_tag="ClothDRAFT_2249" /note="Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959" /db_xref="CDD:186543" misc_feature 50284..50346 /locus_tag="ClothDRAFT_2249" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 50380..50442 /locus_tag="ClothDRAFT_2249" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" ORIGIN 1 ttattatttt ttgttacgat tttatatttg taccatggat gtcatgaatt ttatagggaa 61 ttttttagcc aattttatat cattcaattc aataaaacta ttttttgttt ttaagatatt 121 cgtcaattgc ctttgcggct tttttgcctg ctcccattgc aagaatgacg gttgcggcac 181 cggttaccgc atctccgccg gcatatacac cttctatgtt ggtggcgccg gtgttttcat 241 cgacaataat tccgccccat ttttgagtgg ccagccccgg ggttgttgag gcaattaacg 301 gatttggagt ttggccgatg gcgataataa ccgtttcaac atcaattaca tgttcggatc 361 ccggctttgg cacgggtctt cttcttccgg attcatcagg ttcgcccagc tccatctcta 421 tgcactccat gcctttgacc cagccgtcgt cggtgccaag aattcttgtg gggtttgtaa 481 ggaatttgaa caaaattcct tcttcctttg cgtgatgaat ttcttcaagt cttgcgggca 541 tttccgcttc cgaacgcctg tatactatat aaacgttttc cgcgccaagt ctttttgcgc 601 ttcttgcggc gtccattgcg acatttcctc cgcccacaac ggcgacattc tttcctactt 661 tcacgggagt atcgcagttg gggaattcat aagccttcat gaggtttatt cttgtgagaa 721 actcatttgc cgagtaaact ccgttgaggt tttctccggg aattttcata aatgaaggca 781 atccggcacc cgagcctata aatatggcat catatccttc agctttgagt tcgtcaatgg 841 aataaacctt tcctataacc atatttgttt taatttccac acccagctgc tttatggttt 901 caatttcctc ctgaaccagt ttctttggaa gcctgaattc cggaataccg tacatcaaca 961 ctccgccggg cacgtgaaag gcttcgaaga ttgttacttc gtagccgagt ttggccaggt 1021 cgcttgcaca ggtaaggctt gcaggtcccg aacctattac tgccaccctt ttgccgtttt 1081 tttcaggctt ttcataagaa gtggtgccgt ttttcatgtg ccagtccgcc gcaaatcttt 1141 caagccttcc tatggcaaca ggttcacctt ttatacccct tacacagaac ttttcacact 1201 ggttttcctg cggacagact ctgccgcata ttgccggaag gttgttggtt tctcttattt 1261 tattgtaggc tttctcaaat tttccctgag cgataagctg tacaaactca ggaattttta 1321 cgtttacggg acagccggaa acacaaggtt tgtgcttgca gttaagacac ctttgagctt 1381 cttccattgc catttgctcg gtatatccta aagcaacctc caaaaagttt ttgattctga 1441 cgtttgggtc ctgctccggc atgggaactt ttttcggtga catgttaggc atttttctcc 1501 acccccaatt tgcaattgtg tttttccaaa gccaaggatt cttctttttt atacattgcc 1561 tgccttctca ttgcttcgtc aaaatcaacc agatgcccgt caaaatcagg tccgtccaca 1621 catgcgaact tgatttcacc gccaacggta accctgcagc ctccgcacat gccggtaccg 1681 tcaatcataa ccggattcat gcttacaatg gttttaatgc cgtagggtct tgtgagctcg 1741 ctgataactt tcatcataat tagcggccca atggcaacaa ccaaatcata tttgtttcct 1801 tcttcaataa gtttctttaa tacgtcgctt acgaaacctt tattgccgtt ggaaccgtca 1861 tcggtggtta taaaaagttt gctgcttacg gctctcattt catcttcaag aattatcagg 1921 tctttgtttc tgaaacccgc tatcgtatgg acttcaacac ccatggagtg aagttttttg 1981 gcctggggat atgctattgc cgttcccaag cctcctccaa tgacggccgc tttttttacg 2041 ttctcaaagt gggatgcttt acccagaggt ccgacaaagt ccagcaattc gtctccttct 2101 tccaaagttc ccagtagttt tgtggttttt cccacttcct gaaaaattat tgtcaccgta 2161 cctttttcac ggtcaaaatc ggctattgtg aggggaattc tttcaccatt ttcatttacc 2221 ctcaggatta tgaactgtcc cggctctgct tttttagcta cgtgcggcgc cgatatttcc 2281 atcaacttaa cctgtgggtt gagaatcttc tttttaacta ttttaaacat gcttaggacc 2341 tcccttttct caatcgtaag gttattctaa ttttaacttt tgatgttctt taagtcaatc 2401 gaaattatag ggattgtatt aactatatgg tattatgtta caaatacggg atatatacgg 2461 ataaaaatat ggtaaacaaa agaaaatgaa agtttgccga atggtttctt gcagaaattg 2521 agaataaaaa aacgaatgaa aaaattgtta aattgtttaa tcaaagaaaa atacacactt 2581 tgaacgaaaa gataaaagca agggcaagat taaatttcga aattatttgt tccaactctt 2641 gcaatatggt tacggttttg ctataattca aaatgtcatt ttgttaattc ctcaaacatt 2701 tatttgaggg tatacaatgg cgtataccat atacagtaca aaggtgtata ttggtaacta 2761 gcattattgc ggggagtaat ttgcttatat gcaaatatct ctatataaat aaaaaagatg 2821 ggagaggaat tttaaatgaa gttattggct ggtgtaatgg aacaagtcat taaaagaaat 2881 ccaaatgaac ctgagtttca tcaagcggta agagaagtgt tggagtcgct ggaaatagtc 2941 gccgaaaaaa atccggagta cttaaaagca ggtatatttg aaaggattgt tgaacctgaa 3001 agacagatta ttttcagagt accgtgggtg gatgacaatg gcaaggtaca ggtaaacaga 3061 ggttttagag ttcagttcaa cagtgcaatt ggtccttaca agggcggaat aagattccat 3121 ccttcggtta acttgggaat tatcaaattc cttggtttcg agcagatttt caagaattca 3181 ttgaccggcc ttccaatggg gggaggaaaa ggcggcagcg actttgatcc gaaaggaaaa 3241 tccgacggag aaatcatgag gttctgtcag agctttatga ccgagcttta cagacatatc 3301 ggaccggata ccgacgttcc tgcgggagat atcggtgtag gtgcccgtga aataggttat 3361 atgttcggca tgtacagaaa aataagaaac gagtttaccg gagttctgac aggaaaagga 3421 ctgacatggg gcggaagcct tgtaagaact gaggctacag gttatggtct ctgctacttc 3481 atggaagaag caatgaagac aataaaaggt aaatcttttg aaggtgcgac agttgttatc 3541 tcaggttcgg gcaatgtggc catttatgca acggaaaaag ctcagcagct tggtgctaaa 3601 gtagttgcat tgagcgattc aaacggatat gtttatgatc ctgacggaat aaaactcgat 3661 acggttaagc aaataaaaga ggtagaaaga aagagaatca gtgaatatgt aaaatatcat 3721 cctaatgcaa aatatacaga aggatgttca ggaatatggt cagtcaagtg tgatgttgcg 3781 cttccgtgtg caactcagaa cgagcttgac ggaaacgcgg caaagactct tgttgaaaac 3841 ggatgttatg cggtaggaga aggtgcaaac atgccgtgta cgcctgaagc tattgatata 3901 tttatgaaga acggcgttct ttatgctcca ggaaaagctt caaatgccgg cggtgttgca 3961 acttccggac ttgaaatgtg ccagaacagc atgaggtatt cctggtcttt tgaagaagtt 4021 gacgccaagt tgaaggatat tatggttaac atattcagaa atgtaagagc ggtagcaaaa 4081 gaatacggcc aggaagacaa tcttgttttg ggtgcaaata ttgcaggatt cctgaaagtt 4141 gcaaatgcta tgatggcaca gggagtgtaa gttgtaaaag gaaaaataaa attgaaaata 4201 cgggagtcgg aggtcatttc tctgactcct tttttcttct gcgtattttt ttggcatatt 4261 cttttttatt tctacatatt tttttatttt cttattaatt tttgttttgc attatatgct 4321 gaatttgata taataaaaca tcatagtttt agttgaagga gatgttagct tgaataatga 4381 attgattctc gttctcgact ttggaggaca gtataatcag cttattgcaa gaagagtcag 4441 agaggcaaat gtgtattgcg aggttttacc ctacaactct tctattgata aaataaaatc 4501 aaagaatccg aaagggatta tttttacggg aggccctgca tctgtactgg atcctaaagc 4561 tccaatctgt gacagggaag tttttgagct ggggattccc attttgggta tctgctacgg 4621 tatgcagctg atgagccata tgcttggggg aactgtggaa aaagcagagc agcgtgagta 4681 cggaaaggta aatattacat ttgatacctc aagcatgctc tttgaaggta ttgaaaagga 4741 atcaacctgc tggatgagtc atacctatta tgtcaataac cttcccgaag gttttgtaaa 4801 atgtgcggat actcccaatt gtcctgtggc ggcaatagaa aacagggaga agaaattgta 4861 cggtgttcaa ttccatccgg aagtggttca tactcccaag ggaagagata tactaaacaa 4921 cttcctctac aaaatctgcg gatgttccgg agactggaag atggcttcct ttatagagca 4981 ttccataaac agtatcaggg aaaaagtcgg agataaaaag gttttatgcg ctctttccgg 5041 aggcgttgac tcttcggtgg cggcggttct ggtgcacaaa gccgttggaa agcagcttac 5101 atgtattttt gttgaccatg gtcttctcag aaagtacgaa ggagatcagg ttgaggaagt 5161 gttcaaaaag cagtttgaca ttagtttaat aagggttaat gcggaagaca gatttttgga 5221 aaaacttaaa ggagtgacag accccgaaag aaagagaaaa attatcgggg aagagtttat 5281 ccgggtgttt gaagaggaag caaagaaaat cggaacagtt gactttctgg tacagggaac 5341 catttatccg gatgtgattg aaagcggagt gggagatgcc gctgttataa agagccatca 5401 caatgtgggc ggtcttcctg actatattga tttcaaagag ataattgaac ctctccgaag 5461 cctctttaag gatgaggtaa ggaaagtggg aatagagctt ggaatacccg aagacattgt 5521 tatgaggcag ccgttcccgg gacctggact ggctgtcagg gttatcggcg aggttacaaa 5581 ggaaaaattg gatatactga gggatgctga ttatattttc agagaggaaa taaaaaatgc 5641 aggactggac agggaaatca accagtactt tgcagtgctc acgggtatga gaagcgtcgg 5701 agtcatgggg gatgaaagga cttatgacta tacccttgcc ctaagagcgg tcactaccat 5761 cgactttatg actgccgact gggcaaagat tccgtatgat gtacttgaaa aggtatcgaa 5821 cagaattgta aatgaagtaa agcacattaa caggatagta tacgatataa caaccaagcc 5881 gccggcaacc attgagtggg agtagcgggt acttaaagga tttgtatgtt acaggtaaaa 5941 aagcagtggg acaagatatt taatttgtcc gctgctttta tttttgctct tactttttat 6001 ttactcttat tgacaattct agactattat gatagtctag actatagaga tagtctgata 6061 ggggtgttga taaaatgcaa aaattatatg acagcgaaat taaagttatg gaaattatat 6121 gggaaaacga accgatcagc gcaaagcaga taagtcttat tgccgctgaa caaattggat 6181 ggaacaaaaa cactacctat actgttatta aaaaacttga aagcaagggg tatatcaaaa 6241 gggaagaacc gggttttatc tgtacttcgc tgatttcccg tgaagatgtg tgcagggccg 6301 agacccaaag tcttatagac aagtttttcg gtggttcgaa aaaggcgctt ttttctgctt 6361 tacttcagga tgaaaaactc tcttccgagg atttggacga attgcgaagg atgattgaag 6421 agaggtgatg atatttgctt tcggaaatgt tttattggct ttttaacatg agtatatcgg 6481 cgtctgttgc aggtattgtt gttctgcttt taaggagaat aaaaaagctg ccgaggcgtc 6541 tggtacatat actatgggta attcctttta tcagaatgtg gattccggtg gggattcgaa 6601 gtaaatacag tttaatgact ttgatttcaa agtttactac aaaaagtgta gttctgtatg 6661 acggaacttt ggattttagt tttacaaact atattatggc tgcagacaat tactttcctg 6721 ttacctataa ggaagatatg cttgaaaact tattcagtat tgcatcggta gtttggatta 6781 ttgttgctgt tgctctgtca ttgattttcg caatacttta tgttcttgca aaatctgagt 6841 tgaaagatgc ctctctttta cgggataata tttatgtttc agacaaaata acttcaccgg 6901 ctgcatacgg tgttttccgt cctaagattg ttgttcccaa aggttatgag ttacgaaatc 6961 tacattatat tgtggcccat gaatcggccc atatttaccg caaggataat ctgtggcgta 7021 tcattgccgt tatctctgct tctgttcatt ggttcaatcc tttgatttgg ttgtttttaa 7081 aaaagttttt ggaagatacg gaacttgcct gtgatgagca ggtgttggcg aattgtggcg 7141 aagatgagaa gaaagcttat gcaatggctc ttgttgattg tgcggaaagc atgggtgttt 7201 ttgcctcacc gttcggtgga gcaaaaatac gggtgcgtat tgaccgtatt ttgtcttaca 7261 ggaagctgtc aattatttcg attgcaagtt tgacggcatt tgctgttgca atagggtatg 7321 tgcttttaac gaatgcttct taaaaggggg aagagtgtga agaaaatttt taatgtttgt 7381 tgtgtgatga tgttgcttat ttttgttctg tccggctgta gcaaaacggc aacatcgtat 7441 ggtgaaggaa atgacctgaa atatgttacc gataatttta cattggagga tgcaaagcgt 7501 gagggttatg tcgtgataga ggacggggat gttaccttcg gacaagaagc atggcagaat 7561 tttgttgatt tgtcttccaa gaaaataccg tgtaaaatcc gggttgttca ctattatcca 7621 atcggtgatt cgtccaatta cgacccagag tattatgaaa gtataaaaga tgattatccg 7681 aagatgtata ttctggaact tgtttataac ggagagatat tccgtgtgag ccactacgaa 7741 ggggaagaac tgtatgagtc ggaattcaaa tatcttgtaa agtacgaggg aaaggcagag 7801 actcctgatg caacctacac ttcgtttgta agatatgtgt tggtaaatga tgataaagtg 7861 acttgggacg acattatgca cggtgtcttc agttccaggt tgggtgatta tatatcgtat 7921 agggtgatat acacggattt ggtttataag gaggaatata aatgagtcaa tttaaaaagt 7981 tttgtatatt ttccttggtg ggagtgcttg tagcgtcgtt ttatcccata tttatgggtt 8041 taaaagttat tgacgatatg gtacggaatg gggtggtttt ggctgaaaac tacccaaagt 8101 acataatacc gtatacaccg attagtttgg cagtcataat tgcggttttg ttattaccgg 8161 ttttaatgag atataccaaa aagtatgcat tggcaacagc aactttaata tcccttctgg 8221 tcttttttgt gtcggaactg ttgcttgaaa atatggttat tattacagac aatgttacga 8281 caactcttga aagctggcaa atgtttatgt gttatgtgcc gccggagagt gttaggacaa 8341 ggacatggaa accggttgat gtgctgattg gagattatag tcccgcattt aaaattcact 8401 tctatgctat ttcggtggtt ttaataatta ctcttgtaaa ctgcttttac ggttttgcaa 8461 aaatcattgt tacaaaggat aagcgtagat taaaggcatt gatttttcag gcactattga 8521 ctgttttgtt tcttgggctt tgcatttttg cgtgctttac cgcatttttc agggacggag 8581 aaattacggt gtctgctgtt tcggcaatac ttatgagttt gttttttgtc gtgtttggtt 8641 taacgtcggg cgtatatgcc ggttcatttt tggtgggaaa gaagaaaaca ctggcggtat 8701 tgcttccgtc gattgtggca tcgtctgtta caattgttat gtatatcggt gagatggtac 8761 tgctcagcgg ccatttgtac cgttttggaa cgggattttt gtttgaggaa tttccgggaa 8821 ttgtacttgc tcctgtggat attttggtta ttgtagcatc gggatgtata aatgctgtta 8881 tatgccatgc ttttggtgaa tcgggaaaga ggattaaaaa ttaagtgtaa atggagagga 8941 taactcgatt ttgagaatat acatatactt cactgttccg ggagcaacgg atttgatctt 9001 ctgtttttaa aaaacggtaa atttgcgata gtaagaggca aagcacggtg tgggattagg 9061 caatttgaaa acatatggag gattaaggca aggttcacag agttataata ttgatagatt 9121 aaaaaaatat ttgtattatg gcgatggaac ctatgatgat ttagtaaata cacttttaaa 9181 tgaggcaatg aatgaccagc ttgaaagttt tgcttcattt tacagaggga aaaagctata 9241 tgaattgcca agaggatggc ctgaaattcc ggcaaaaaga caaagataaa ggaggataag 9301 gaaatatggc gatgacccct attgaaatga ttgagttttg cgacagtcag gttaatggag 9361 gtattcaaag agggttagaa aaaggtaaag ctaatgggga ttattacctt atagcactaa 9421 attatgatga aggattcaaa tgtaggttga tgcaaacgtt aatatcttgg agaataggta 9481 taggtaatcc aaaagaatat cttattaaag ctattgacat agctaatgag gctatttcaa 9541 cactttcgaa gtttgaaacc aaaaatattt taaaagattt tcctgttgat accgcattaa 9601 ttgcttctta tttggctgaa agaccgttgt atgtagatga gaatttgaat atgaatacat 9661 caggtcttcc gtttgaggtt attttggacc ttgaaatggc aaagacactc cgaggtgcca 9721 ataatgagga tgcctggtcg agtattatcg atcaatataa acaaaagaaa cgttcagctt 9781 tatgttataa tacatattgt ttgtacaagg aattgctttt taccgaagat gcagaaaaag 9841 ttgagccaat tgtaagacag cttgaaaagt tgttcttaaa acgtaaaaag aatccttatt 9901 atagtggagg agagttaaca gaaggtggag gacctagtaa tgatgtaact gttgactatc 9961 gattaggtgc aattttaaag tttaaatcct ttaaagggga gtctatacat ttgtggagat 10021 gggattaaat tcatgctgac agctgttgga catcacttgg ctaaaacagt tgtaagatag 10081 ttgagttaaa ttaaaatgga taaatggatt attttaaaaa tcctcggttg cagacaaaca 10141 tacagccggg gtttttgttt tggagcgatg taaataaagt ccgtcaattt gcttttcagt 10201 tcacgatata ttcagaagaa taaaagcagt ataccgcatt tatcataaat gtccgtaaca 10261 ggcaaaaaga tattatgtct ataataaaat atgactacaa caatgtcgtt cagttgtttg 10321 taaaaaattt aagtgagtct aaagagtatc ataaaaacta tctagagctg atttcaaaaa 10381 taaagcaaat ggatggggta gtagatatag gaagtttttg ttatggcagc atttctttca 10441 aagagcttga tgaaaatatt aatttgagaa aaagagtttt ttctgcgatt ggaaagactg 10501 atcagtttga aaatataccc ctgttaaatg cgttatatat cgagagtgca atgattcaca 10561 tattagaacc cccgatatac aaaggaaggt tttttgagag tgaagatttc gaagaaagcg 10621 atgaaattcc tcttgttgta ggatatgcct ataaagatat ttttgagata gggcaaacct 10681 ttaccgttac tgacgaatca ctgggaatgg caggaactta taaagtaatt ggtattcttg 10741 ataaaggaag ttattgattt agcgactaca atatattgga taatcaaata gaagacattt 10801 ccatattttg tatagctcct atggccaggg aactttatga aaacaatatt tttgtcctga 10861 ctttaaattc taaaatgctg tacgtggtag gcggtaattt gagcaatgtg gatgcagtga 10921 gaagaaaaat atccgatttg gctaaagagt ataaaatgag tatccgtcag atgacagtaa 10981 aggaatataa tgacgcgaaa aattcagaat atatggaagg tgaaagtgcc aggatattta 11041 catcttaata atgattatac tttcagtatt tggcataatg tccatatctg ctgcgaaatt 11101 gctttccaaa agaagagaaa taggcatccg cctttctttt ggtacaagca aaaggggtat 11161 cattttcata ttttccggcg aattatttat tttatttgtt atatcgcttc ttataactct 11221 tttgattcac aatattagta ttataaacaa gagcgaaatg aaaaagtatt tttataactt 11281 tagctatggt ctcaatattc aaagtgtggg agttcttctt ggcattatcg ttttgatttt 11341 tattttcagc tgtattgttc caattataac aattaaaaag ttttcactta gagatttgat 11401 tggaggttat gagtaatgaa aaacgcaatt ataagattgg agaatatcag taaaatatac 11461 ggaaaagacg attataagac agttgcttta aaagatataa atttagaaat tttcgaaggg 11521 gatttcgtgt caataatggg gccgtcaggt tccggcaaaa caacgctgct gaatataatc 11581 ggcttcatag atacgccgac cgacggtaag tattttctta aagggcagga tgtaaacaaa 11641 atggccaggg gcaagtttca caaattaaga ggcaccgaag tgagttttat attccagcag 11701 tttgcccttc ttaaagacta tacggcatat gaaaacattc agctgccgct tttatataga 11761 aaaatgtcaa gaaaagagaa aaaagcaaaa atactttttt atgccgaaaa acttggtata 11821 ggtgatattt tgcacaaaaa accgtctcag ttatcagggg ggcaacagca aagggtggct 11881 attgccaggg cactggcaag tgaagccaac attatccttg cggatgaacc taccggagca 11941 ttggatcaga aaaaaggaaa cgagcttatg aagatacttg ccggtttaaa taaagagggg 12001 aaaacgattt tggtagtaac tcacgatcca aacattgcaa attattgtat cagaaacatt 12061 cgtattgaag acggtaagat aataagtgac agttcgagtt tacaggatga accgttaaaa 12121 acttgttagt ttcctgtttt ttcggggtta ttgtttgtgg agatggaatt aaattgatgt 12181 tgacgggtat atgcagatac tcagacgatt tggtacaaat cttgtcaatt aaaacactta 12241 atttgtgtgc gggatttact gtattaaacg caatatcgtt tgtaccaata tgcaatgata 12301 cattatccaa ctttgcggca tccatctatt cattgattct ggcgtcgatt tgttctattt 12361 tccaaccggg atatctttca tggttcttgt atgcgaccgt cattattcaa atcggcattt 12421 tcagagttta ttgaactttc atttacaagt ttgaataaat aactttttag tagatataaa 12481 tctgatgaat ttgctttgcc gtcggagttt acattctcca aattatttgc tcccgcaatt 12541 ggcgtgcttg acattgtaag tagtgcagcc ggcaaaagaa ttaaagagaa tattttcgat 12601 agaatatttt ttatgaattt gcaaaaattg attaaaagct aatataatga aaactaaaat 12661 tttgtattac aaaatgaaat aattaatttt aaaaaagagg aatttggcta aagatgtcgt 12721 aatataactt taaattccat tttttataca aaattttgac aattcttggc agaagaaagt 12781 cggtattata ttggctgatt aggagaaaat tgcgaaactc tgacaaatga aatagaaact 12841 ttagcaaaat acagaaattc catttttgaa tatactaagc atacttacag ctcttttgga 12901 gatttcgcag ttaaaataaa gattacttca tgaagaaagg gttgggtttt atgcttggtt 12961 taattttagg aacgattact ttaattctgt cagtgttgct ggcagtagcg attcacagct 13021 ttacgtcttt tgatgttatg tcattttctg ttttttatat tattccgatg ggttcgattt 13081 gtattggcac aatcgcatgt ttgggttatt atttgggctt gtttgcaagc aacaaaaaag 13141 tctctcccaa tctatttatg attggtttgt taattcctat tttatcgtat ataaggtgtt 13201 caatacggct attatgtcac agcgtatttg gatgaagata tgaatctgaa ttataaaatg 13261 gtaggggagc atattagtaa ttatgcaatt ggagactcgg aggaaccgct caattttatt 13321 tcatttacaa agctaatggt tgaatcaaga actatttctt tctatcatcg tagtcggact 13381 attggtgaag tgaaaggaaa tgctgtcgta aattggatat tctttattat tgatggcctt 13441 ggctctatat tcggaagtgt tatggcatat tggcttgttt tgcgtgacgc aaagtactgc 13501 aatgattgca aacggtatat gaagaaaaag tccatattga agtttttggc tacggacata 13561 gacagaacaa ttaagtttca ggatattgac aatttgagtt ctgatgaaat aaaggatttg 13621 tttttaccta cgaacgttgg taaaaatgaa cattatgaaa taattgttta ttggtgtcag 13681 gagtgtgata agggttatct taaaatgaaa tacatgggaa aaaattcaaa aggcaaaata 13741 gaagagaatt tatcaaaaag caaagaattc gaaatttcat cttatactgt taggaccctt 13801 tgcgatctgt cccgtaatgg ctttagagat aaggttgtag tttaaacttt gttaagttta 13861 aaaactatca aacatataat cacgatgtta gatatttgtt gcgaaacgtg caaatacctt 13921 atgtcaagtt ccataatgtg aaccttaaaa tccacctcgc tgctctttga gaggtggatt 13981 tttcgtattg gcgaaaggaa tgtaaatgac tgtagataat aacgaataaa aatgaaaaat 14041 aacatattga caagaggggg taaaaggagt tatacttaag ttagttaatt aagcgaatta 14101 agtaagtaag ggggcatgtc tatgttacaa tcggttatgg tatctcctgg gaagattgag 14161 ttccatgagg tggaaaaacc ggaactaaaa cctggacaag tactaataaa gattatgaga 14221 attggcatat gtggttcgga tattcatgta aatcatggaa aacatccttt cacaaagtat 14281 ccggtaactc aaggacatga agtaagtgga aaaatcgtcg aagttgcaga agatgtggag 14341 catctgaaag ttggccagaa agtgactata gagcctcagg ttgtatgtgg taaatgtcat 14401 ccgtgccgta caggaaaata taacctctgt gaggaactaa aagttatggg attccagacc 14461 gttggcgcag gcagcgaata ttttgctgtt gatgcgaaga atgtaacgac tgtccctgac 14521 catctttctt atgacgaggc cgcgatgatt gagcctttgg ctgttaccgt tcatgcggca 14581 aacagagtcg gtgatgtgaa ggataaggac attgtagtaa taggtgcggg tcctatagga 14641 attttgctgg ttcagaccct gaaagcaaaa ggtgcccgca aggtaatggt tacggatgta 14701 agcgattatc gtttggaatt ggcgctcaag tgtggtgctg attttgcagt caataccaaa 14761 aaagaagatt tcggagaagc gatgcttcgc tgttttggac ctgataaagc agatgttata 14821 tatgattgtg cgggcaacaa tacaacaatg gaacaagcca taaaacattc ccgcaaggga 14881 agcataattg ttctggttgc agtatttgaa ggtatggcaa cagtcgatct tgcaactctt 14941 aacgataagg aactggattt gaatacgaca atgatgtatc ggcatgagga ctatgtggaa 15001 gccattgagc ttgttgaagc gggtaaagta aaattaaccc ctctgatgag caagcatttt 15061 gcttttagag attgggaaaa agcctatgag tatattgaca ataatcgtga aattactatg 15121 aaagtcctca ttgatgttaa taacgatgat gattaattgg gataaatttg ataaaataat 15181 caggtgagat tctatgtttg atgttgttgc ggttggagag ttgttaatag attttttgcc 15241 cgctggtaca aatgaaaatg ggatgcctct tttttcgtcg aaccctggcg gagctccggc 15301 caacgttctt gccatgctgt ccaaactggg agccaaaact gcttttatcg ggaaagtcgg 15361 aaaagacggg tttggacagt ttttgaaggc gacgcttgat aatgccggaa ttgatacatc 15421 caacctgttg atgagttcca gcgaaatgac aactttggca tttgttcatc tgaatgagaa 15481 gggtgacaga tcttttagtt tttatcgaaa gcattgtgcg gatgtcagtt tggacgccgg 15541 cgaacttgat aaagatttgc tcagaacatg ccattttctg cattttgggg ctgtctcttt 15601 aactgatgag ccgagtcgta ctgcgacttt ggaagccgcc agaattgcaa aagaagcagg 15661 agcaataatt tcatatgacc cgaattaccg gcctgctttg tggagtaatg aacacgaagc 15721 acgtaaatac atgttaaagg cagttgaata tgctgatttg gttaaagtca gtgaagaaga 15781 actttggctt ttggcggaaa gtgaggattt ttccaaaggg gcgcacaaac tgcttgccat 15841 gggtccgtcg gttgtctttg ttacttgtgg tgaaaaaggc tcttatgttt tcactggaag 15901 ttgtaaggcg aatcactgtg gatacgacgt aaaagtggtt gatactaccg gggcgggaga 15961 tgcgtttgtg ggagccatgc tatggcagct taggggtatg tctttggaag aaatatctca 16021 gatatgtgag caaaaatggg gagaattact ggcattttca aatgctgcag gtactattgt 16081 ggctactaaa aaaggtgcaa ttcctgcaat gcccgacctg gatacgataa atacttttat 16141 gaggcagttt cttgaagaga agtaaaaaag gcagagtatg atttgacagt agatataatg 16201 acggaaaggg aggtgctggc gtggataagt ttacgaaact tgatttaaac agtataacaa 16261 gcaacaatag aatgaatata tttaattgta ttcttgaagc aaaggaaata aacagagcag 16321 ttatagccaa aaaagtaggg ctgagcattc ctgcggttat gtccattacc gatgatttga 16381 ttcagaaagg tattatctat gttataggca agggtaaatc cagtggaggg aaacgtcccg 16441 aattgcttgc ggtggtcccg gacaggtttt tctttgtcgg agtggatgta ggaagaacat 16501 ctgtaagggt agttgtaatg aacaactgca gggatgttgt ttacaaagtg agtaagccga 16561 cggaatctgt tgaaccagat gaattaataa atcagataac cgaaatgact atggaaagta 16621 taaatgaatc aaaattcccc cttgacagag ttgttggtat aggtgttgca atgccgggct 16681 taattgagcg gggcaccggc agggtaattt ttagcccgaa ttttggctgg aacaatattg 16741 ctttacaaga cgaacttaaa aagcaccttc ctttcaatgt actggtggaa aacgcaaatc 16801 gcgccctggt tataggagag ataaaaaata cacagccaaa tcctacttca tgtattgtcg 16861 gggttaacct tggatacggt atcggatcgg cgatagtctt accaaatggt ttgtattatg 16921 gggtaagcgg aacgagtggt gaaattggac atattattgt tgaaaaccat ggttcatatt 16981 gttcgtgtgg caattatggg tgtattgaat ccattgcaag cggagaagcg atagctcgcg 17041 aggcccgtat tgcaatagcg aataaaatac aaagcagcgt tcttgaaaag tgtgaagggg 17101 atttgaagaa aatagatgcc aaaatggttt ttgatgctgc aaaggaagga gatcaccttg 17161 cccagtccat agtggaaaaa gcggctgact atataggcaa gggtttggca atcaccataa 17221 acatgcttga ccctgagcag atcattcttt gtggtggttt gacgttaagc ggcgactttt 17281 ttatcgatat gatcaaaaaa gcggtatcca agtatcagat gcttatgccg gaggaaatgt 17341 taaaattgtt gttggtaaaa gtggactcta tgctactgcc ataggtggtg catggattgt 17401 tgcaaataat attgattttc tgtcaagtaa ctaagaactc tttagttaat gcatttcatt 17461 tttcgctgta tccaatcagt tttttattta taaatattaa aaattgaaaa aaatacattg 17521 actttctata taaaaaggat atataataaa attgtagtta gttaagttaa ctaagtaatc 17581 gtttattaaa aataatcata attttttctt cttagtagta cgaaagattt agtatcaatc 17641 aaagtatcat taagtatcaa ttcaaaggtt gtagtcctgc agtacttaat ataccccacc 17701 gattgataga tgcaactaaa gtaaagttgg taaagcaagg aggagcgtaa atggataatg 17761 ctttacttct ggaagttaaa gggctttcaa aagtattccc tggaacacgt gcactaaatc 17821 gtgtcagcct tgaagtaaga aaaggtgaag tacatggttt gtgcggagaa aacggtgcag 17881 ggaaaagcac tttaatgaac attgtaggtg gagtttttcc tgcaactgaa ggaattatga 17941 aattcgacgg caaaattttc aatcccaaaa accctaagga ctctcaggat gcaggaatag 18001 gttttgttca tcaagagctt tgtttgtgtc cgcatctttc ggcagctgaa aacattttta 18061 ttggaaggct gccaagcaaa ggggataaaa ttgactttaa aaagctttat gaagatgccg 18121 atgcgatact taaaacttta gatgccaatt tcagcagcaa aactcttgtt agtaatttaa 18181 cggtcagtga acagcaactt gtggaaatag caaaatctat ttcacttaat tgtaagctcc 18241 taattttaga tgagcctacc agttccctga ctgacaaaga gacagcaaga ctgttccaag 18301 tggtcagaga cctcaagaag aaaggtatat ccatactgtt tatatctcac cgtatgaaag 18361 aagtgttcga aatatgtgac cgggttacag ttctaaaaga tggttcgtat gtttgctgta 18421 tgaatatttc ggaaattaca catgaagatg taataagagc gatggtaggg cgtgaccttg 18481 gcgagcttta cccgcctaaa tcttcaaaaa ttgaggaaga caactatatt ttaaaggttg 18541 aaaatttaag cggaaatgga tttgaaaatg taagctttac attgaaaaaa ggagaaatct 18601 taggtttcgc aggcttggta ggagcaggtc gcagtgaggt catgagagga ttgtgtgcaa 18661 tagatcccgt taaacgtgga gaggtttatc taaatggtga aaaacaaaag tttaaacggt 18721 acaaggacgc agtaaaaaaa ggaatttgct atcttacaga agacagaaaa aattcgggtt 18781 tgtttttgca catgagcata gcccaaaata tcagcagtgc aaaccttgaa gctgtttcaa 18841 aacgtggttg gattataaag aaacgagagt acagcttgtc tgaaaaatat gtgaaggcat 18901 tgtcaataaa gattccgggt ttgtcatatc ctatcagtaa tttgtccggc ggcaaccaac 18961 agaaatgcct gatcggaaaa tggctttcaa caaatcccaa agtcataatt atggatgaac 19021 ctacacgagg cattgacgtc ggggcaaaac gtgaaatcca taatctgttg cgttcattaa 19081 gtgagcaagg cgttggtgtg ataattgtct ccagtgaact gcctgaaata atcggtgttg 19141 ctgacagaat tgcggtgatg catgaaggga ggctggcagg atttttacag ggagaacaag 19201 tttctgagga aaacataatg aaattggctt ccggagcaaa tttatcatag gaggaaatgc 19261 aatgaaagac aaaattacag gaataataaa aaagatattt tctcaacgcg aagttactgt 19321 atttctgatt attcttttgg ttgtggcaat tacttcgatt attcagccta agttcctgaa 19381 ctcaaacaac atgagatcaa tagcactgag tgtttcagtt gacggtttgt ttgcgattgg 19441 tcttacgatg gcgttgattt tgggtggaat agaactgagt gttggaagtg tggctgccat 19501 gacatgtgtg ataaccggtt acctggcgtt gcagggggtt aatattgggg ttgcttgtat 19561 tgcaagtatt gcaagtggct tggttgtagg tcttttcaat ggttttatga tttcaaaaat 19621 aggtttgccg cccttcattg ttacattggg tatggaaaat cttgcgcggg gtatggctta 19681 cattataaca acaggttcac cgctttctgt ttcaggatat ttacctcaat cgttccgctt 19741 ctttgcgaca ggatcagttt ttggaatacc cgttctcttc atcatattta taataatttc 19801 ggcgattgca tttatcttta tgaagtattc aaagatatgc aggaatatat actacgtcgg 19861 aagcaatgaa aatgctgcaa gactttccgg tataaatgta gacagggtaa aaatcggtgt 19921 atatgtgaca attgcgttaa tctccacatt agcaggctta ttgtctctgg cacgctttaa 19981 cgtggcaacc ccggaactta gcaagggtgc tgaaacaacg gcaatttccg cggcagttat 20041 cggcggaaca tcgatgacag gtggttccgg aggcgtactg ggaactgttt tgggtatttt 20101 cttactgaag atagttaatt cggcacttgt tatgatgaac gtttcggttt attggcagga 20161 gtttgttcag ggagcaattc ttgtactggc tgttaccatt gactatttga gtcaccgtaa 20221 aaacggcggt ccaagcttta taatgaaatt cttcggattg gacaaattgg cttcaaaaaa 20281 attagatgac aaatcttcca ggcaaattta atttttaaga attttggtgc tttatgcact 20341 gaaagataaa aatacatttt atccttaaaa atgtaaggag gtaatttttc atgaaaagat 20401 ttttagtatt attgcttgcc atttcgctga tatttacatt tacagcatgc aattccggtt 20461 caggctcagg aaatggacag gcaaaaggct atgtaggcga tccttcggat gaatactaca 20521 tggttacttt cctttccggt attgattact ggaagtactg ctttgaaggt tttgaggatg 20581 cagctaaagc aattggcgta actgcaaaat ataccggtca gacagatact gatgtttcag 20641 gtcaggttgc agtgcttgaa caggtcattg ctcaaaaacc aaaaggtata gcagtaacag 20701 cggttaattc aacagcattg gcggatacaa tcaattcagc tattgaacaa ggtatttcag 20761 ttgtatgctt tgactctgac tctcctactt caaaccgttc cgcatatctt ggaaccggta 20821 actatgcagc aggtcagaag gcggctgagt tcctggtacc gttggtaaac tacaaaggta 20881 aaattgcagt attgtataca gttggtgcag aaaacagtga atcccgtgtt cagggttttg 20941 aagactggtg taaacaaaat gcgcccgaag tttccctcgt aaaagttaat gatgcaggcg 21001 atacaactgt cgcagcggac aacctggcgg ctgcattaca ggcaaatgat gatattgttg 21061 gtgtattctg tgtagacggt gttgcaggta ctgcaggacc gacagcagtt gcagaatcaa 21121 agaaagattt aagagttctt gcatttgacg ttgatgtgac agttcttgac aaggttaaga 21181 gcggtgaaat tgatggtaca gttgcacagg gaatgtataa catgggttat tggagcctga 21241 tgatgctcta tactgaggca aacggtcttt cgtccaaagc tcttccgggc aatcttgaca 21301 caggtgttgt aatagtaaca aaagataatg ttgatgagta ctatccaaag aaataagaat 21361 aaaataaaat cagcatgaaa ggaaagtaag tttatgaaag catttaacta ttatgcacct 21421 actgaaatta ttttcggatg cggcagagtt caggaaattg gatcaataac tgcccaatat 21481 ggaaagaaag ctttgctggt aactgtaccg gaatttccgg aagtaaagga gctctatgaa 21541 aaagtaaaga agtctcttag ggaaaatggt gtggaagtag tacattttga cggtgttatt 21601 ccaaatccca ccactgatgt tgtaactgaa ggagcaaata tggcaaaggc tgccggggtt 21661 gatgtagtta ttggattggg aggaggttcc tcaatagata ctgcaaaagc cattgcagtt 21721 gaagcaaccc atccgggaac tgcctgggat tataactgcc acactccggg ccccacatct 21781 gctaccctcc ctattatcgc aataggaaca acagcaggaa ccggcagcca gtgtacacaa 21841 tgtgcagtta tcacaaaaac aagtgaaaag gataaatccg caatttggca caaaaatatt 21901 ttccctaaag ttgcgatagt tgatcccgaa gtgacagtca cgatgcccaa aagtgtaact 21961 gcgcagaccg gttttgacgc ttttgcccat aactttgaag catatctttc cgtgaaaacc 22021 agtccgttag ttgagatgat ggcaatagaa gcaataaaga tgattaagga atatttgcca 22081 aaagctttgg agaatccaaa cgacattgag gcacggtcaa agatgtcatt ggctgacact 22141 ttgggtggac ttaccaattc caacgcagga gtaacactgc cccatgggtt gggaatgcaa 22201 gtcggcggcc atgctcccca tgtatcccac ggacaggctt tggcgataat atatcctcaa 22261 tttacaaggt acacatacgc ctgggcaatt gaaaagttcg ccaaggttgg aagaatattt 22321 aatcctgcat tgaatgaact ttccgatgaa gaagcggcaa aagaagcgtg tgtggcaatt 22381 gatgatttcc tgaagaaaat aggtttgtgg attggtttta aagatgtgaa tgttacgaaa 22441 gagcaaattc gtgaaatagc agatgatggt caggttttag gtgattacct caacaatcct 22501 cgtgtagcaa cgattgatga gatgtacgag ctactgatga attgctatga gcgcaaagaa 22561 tgaggtggac gagaatatgg ttgaaacagg aatcttgaat agggatattg ctgcagaact 22621 tgccaaattg gggcatacgg accgcgttct tattgcagat gcagggcttg ccatacccaa 22681 tactaccaaa gttattgatg tttctcttga cgtaaatttt cccacaaccg tggatgtatt 22741 aaaagtactg ctaaagcact tcagcgttga aaagctcatt ctaagtcagg caacagttga 22801 tgtaagtccg tcaaggtata aagaatattt gagtttgttt gatgaaagcg taccctgtga 22861 aattgtagag cattctactt tgcgcgatac tcttacaaaa gaggttaagt tcgcaattag 22921 aaccggcgat tttacggcaa attcaaatat aatccttgta agtgccggag gtcctcgttg 22981 gtactgcgaa aacttggagt gagtttttcg atgcacttgt gtacttgctt taattaaata 23041 ctaaatttaa tgcggaaagc acttgggaat gtcccaggtg ctttttgcag atttcagtga 23101 ttaatcgcaa cacgaaaatt tgtagccgct attcttgtta gttgtggtta aatatgctaa 23161 aataacattg ttgtaataga gaggattata aggtgctgtt ggaggaaggt atgtaaaacc 23221 cttcctttta ttgcgtttgc tgcataggcc gatactatta attattaatt gttttattat 23281 tttaaagtat gagtagaggt tcaactttac acttataata aattaaattg aaccggataa 23341 aatcaactga attattttta aaggcgtgta gtacactata aatcatggta ggatacatga 23401 gttaaaaata gcatcctgga ggacatttat gaaaaagttg tcggtttatt taaagggata 23461 tataaaggaa agtattcttg gacccttatt caaacttttg gaagcatcat ttgaattact 23521 ggtacctatt gttatcaaat ccattgttga taccggcatt gggcgggctg acaaagtata 23581 tatcattaaa atgtgcctgt tgttgattct tttgggtgtt gttggaatgg tatgttcggt 23641 aacggcccag tattttgccg ccaaagcttc agtgggattt gtgacaaagc ttcgccgtgc 23701 actgtttaga catattggcc aattgtctta tacggaaatt gacacccttg gtacatccag 23761 tatgattacc cgtatgacga gtgatataaa ccaggtacag accggaatga acctgacatt 23821 gcgtctgttg ctgcgttcac cttttattgt gtttggtgcc atgattatgg cgtttactgt 23881 ggataccaat gcggctttta cttttgttgt agccatccct gcgcttttta tagttgtttt 23941 tgcaattatg ctgctgtcca ttcctcttta caggaaggta cagcaaaggc ttgacagagt 24001 gttaaagtca acaagggaaa atctcacagg tgtccgggtg attagggctt ttcgccttga 24061 agaaaaagaa atagctgaat ttgacaaacg caatgaagaa ttgacctcaa cacagatatt 24121 tgtaggcaga atttcagctc tgatgaatcc tttgacctat gttattatta atcttgccat 24181 tatctggctt attcatatcg gtgcaatccg cgtatcaaag ggactgctta cgcagggagc 24241 tgttttggca ctctataatt atatgtccca aattcttact gagcttataa aattcgcaaa 24301 cctaatcatt agcattacaa aagctgttgc cagcgccaac cgtatcagtg cggtgctgga 24361 tgtagaatcc agtttggtgg agaaagagtc tgagccgcaa ggtgacaggt ccgaatttat 24421 cgttgaattt cacaatgtag gattgacgta taaaaatgcc ggtgctgaag ctttaacaaa 24481 tattaatttt tcagtccgcc gcggtgaagt ggttggtatc atcggcggta caggttccgg 24541 taaaacttct ttggtaaatc ttattccgag gttttacgat gccacggtag gcgaggttat 24601 tgtagacggt attaatgtta aggattatcc tttgaaaaag ctgcgtgaca agataggtgt 24661 cgttccgcaa aaagctgtgc tgtttaaggg cagtatccgc gaaaatatgc gttggggaaa 24721 taaaaatgca accgatgaag aaatcatgga agccattaat attgcccagg caggagaaat 24781 tgtggctcaa aagaaggaag ggcttgattt tcttattgaa caaggaggaa aaaacctttc 24841 gggagggcag cgtcaacgtt ttaccatagc acgggccatt gttaaaaagc cggaaatctt 24901 aattcttgat gacagtgctt cggctcttga ctttgcgacc gatgcagctc ttcgcaaggc 24961 tcttcgtgag ttaccgtgga atccgacaat ttttattgtt tcgcaacgta cttcatcgat 25021 tcaacatgct gataagatta tagttctcga tgacggagaa attgttggta tcggtaagca 25081 tgacgagctg cttgaaactt gtgaggtata tcgcgaaatt tatgactcac aattcaagaa 25141 ggaggaaaaa tgatatgaaa agcagaaaaa ttcaaatgga cactatccga aaggttctca 25201 gatatataaa aaaatatcgt gttcttttat tcatttccat tcttcttgct gcgtccacag 25261 tagccttaac tctctatgtg cctattctta tcggtaacgc cattgattat atcgtaggac 25321 cgggtaatgt aaattttgaa gtcgtagcga aaattcttgt ccaaattgct tttgccgttg 25381 gtattactgc tatatttgaa tggtttatgt acacaataaa caataatatt acttaccagg 25441 tggtgcggga tattcgtgaa aaagcttttc gaaaaattga gattttacct ctttcatata 25501 tagattctca tccccacggt gaaattgtaa gccgtgtgat tgctgatgtt gaacagtttg 25561 ctgaaggtct tctgatgggc tttacccagc ttttcaccgg tgttgttacg attattgcca 25621 cgttgatttt catgctcacc atcaatataa agattacttt tattgtagtt atcctcacac 25681 cgctttctct ttttgttgca aattttattg caaagcatac ctattccatg tttaagttgc 25741 agtccgaaac ccgcggagag caaacttcgc ttattgaaga gatgataggc aacgtaaaag 25801 tggttcaggc gttttcctat caggaagaag cactgaagaa gttcgacgag attaatgaaa 25861 ggcttgaaaa atactccctt cgtgctgtct tcttttcgtc tttgaccaat cctttaaccc 25921 gttttatcaa cagccttgtt tatgcggcag tcgcccttgc gggcgcaata gcggttatca 25981 gcggtgatgt gggaagtacc atgacggtgg gcggactttc catattttta agttatgcca 26041 gccagtatgc taaacccttc aatgaaattt ccggtgtgat aaccgagatg caaaatgccc 26101 ttgcctgtgc aggacgcgtt tttgagttga ttgaagaaaa acctcaggtt ccggatgctg 26161 atgatgcagt cacgctcaaa aacgccagcg gcaatgttgt ttttgacaat gtggcttttt 26221 cctatgttcc tgaacgtcct ttgattcgaa atttaaacct tgaagtaaaa cccggacagc 26281 gtgtggcgat tgttgggccc accggttccg gcaaaactac tgtgattaat cttttgatgc 26341 gtttttatga tgttgattcc ggcagcataa aagtggaggg tatagatatt cgaaacatca 26401 cccggcaaag cctgagggaa aactatggca tggtattgca ggatacgtgg ctcaaatccg 26461 gtaccattcg cgaaaatatc acaatgggaa aaccggacgc aacggaggag gaaatcattg 26521 ctgcggcaaa agccgctcat gcccacagtt ttatcaaacg gctggaaaac ggctatgata 26581 ccgtcatcag cgaggaagga ggaagtcttt cacagggaca aaagcaattg ctcagtattg 26641 cccgcgttat gctttgtttg ccgccgatgc ttattttgga tgaagcaaca tcttccattg 26701 acacccgtac cgaggtcaaa attcaggaag cctttgcaag acttatgcaa ggccgcacaa 26761 gttttgttgt tgcgcaccgc ttgtccacaa tacgggaagc cgacgttatt ctcgtgatga 26821 aagacggtga tattatcgag cagggtaccc atgaagagtt gctctcgaaa aaaggttttt 26881 atgccaatct gtataacagt caatttgcgc aatgatccaa atttgttatt gcgtgagcca 26941 tgataaaaga atgaaaaatg aaagtaattt catatggata tggtaatatg taatatatct 27001 attatataat ataatgtaat tgcagtagaa aatagattgg aggtttttta taatgattat 27061 aaccacaaca aacgggatag aaggcaaaag agttgttgaa tacaagggca tagtttgcgg 27121 agaggtaatt tccggtgtgg acttcataaa ggattttgca gcgggcctta cgaatttttt 27181 cggcggccgt tcaaaatcat atgaaggcga attgattgag gccagagagg gagcaattcg 27241 tgaaatgaaa gaaagagcga ttcagatggg tgccaatgca ataataggag tggatattga 27301 ctatgaggta cttggacaag gcggaaacat gcttatggta acggcttccg gtactgcggt 27361 ggtaatagag taattatagg ttgagaataa ttaaaagccc tgtcagatat ctgcctgatg 27421 ataaattgcg cagttttcgc agggcttttg ttttgcgcgg gttttttata tagtaatatc 27481 agaattttag tgcatatcag ttttattgca catcagaatt ttttgccacc accgccatgg 27541 gttcttccac tgcttccggt atgggtactg cttacattac ctccccttga accggaactt 27601 tcgctgattc ttgttcttgt tgtggactcc cttatataat catcccttgt ttcagtgagc 27661 acaaaggaac cgggctcttc ataggtgccg gaatttattg taatctttcc tttgctggac 27721 aacgacagaa ttaatgtggc tcctaaagat ataacaagag cggttatata tatggagact 27781 gattttatcc ttcgggatac tttgtcagcg tacgttatat ttgtgtcgga ctgagacctg 27841 tattgcccgt atggaacacc gtcataggca tagtttttga catccctgat aaaggttttg 27901 caagcgctgt agtaatcatt gttggaaaga tgtctgatta cattgtcttc cattatggaa 27961 attctgttgt ctgtgaaaat atcaatggca tcgccacatg tggatatcca gatttccctg 28021 ttttgcatgt taacaagcat caacaggccg gactttcttg tgcctatgcc atacccgttg 28081 taatcgtaaa aatcatccgc aaaatcgcgg gaagacttgc cctgggtgtt atcggtaata 28141 acgatgacga catcaagctt gtaactcttt tttatgctgt caatgtcgga ctgaaggctt 28201 gcaatttcct cagcggtaag ataattcagg tagtctttta catttttaga gctttcggca 28261 aaaaccaaag cctgtgatat atatgaaata aaaaagaaag acaacaaaat cagagctgaa 28321 atacttgact ttttacgcaa ataaggcacc tccaaacaca cctataatcc atacgagcag 28381 gaaaactgca actgcaaaaa ggatttgttt cggaagacaa agcggagtgt ctccgacgac 28441 ttttccggtt tgtccgttta tcatgaatat gtggcttttg tctttgtatt tgtttaccaa 28501 taaataaacc ggcagcattg aataactttg ctcgatttcg gatatattta tgtttttgct 28561 tgttatactg caggaagaat atccgctgac agtgcctctt agtctttccg acagatagtc 28621 ttttactctg tctttaagaa tagttacggc ttcggcggat tcgacatcat atctttcggc 28681 cataaaaccg gacatatatt tcatggaaaa gtctttcaaa tctttgtaat caaaaggttc 28741 tatcatatgc atatatttat cgtccagttt tttggatgca tccacaggaa ttctcttata 28801 gcgggcgtgt ccccttctta gaatgctgta atactttgtt tgagtgtatt tgtagttgcc 28861 ctgtctccag gaatggactc tggtggcttc tccgctgata aagccgtccg ctttgcagtc 28921 aaagagccag aagggagcat atattccggt tattttgtca acttcctctt ttaatttaaa 28981 ttctttggga gcaaatatgc gtttttttat ccacttttga tagatttcct ttgcctgttc 29041 ctttgtcaat ctgaaaggaa ttacatttct gggtctgaat ctcccggaaa atcttgattt 29101 gatgactgcg ggacttttgc agtaaataca aaaggtggct gaggtggtat tgtcagcaat 29161 caattcggct ccacagctgt tgcaaatata tgaatccaat tccggcattt cctcattgag 29221 aagttcctca ttgtcggata tgtcaaattg atccttttcg tattcattga agcagtagtt 29281 acatttccat ttttgtgaag gtggatcaaa atccaatcct gcaccgcagc tgggacattt 29341 gtattctttt actgaggtca tacatatcct cctttaaaac tttaaaacta ataatggaac 29401 gtatgttaaa tcattgcttg ttttcgtaaa aactttttaa aggcctgctt cataaagaaa 29461 aaatacagtt gtcattcaca gttaaattat acaggttaaa gaaacaggtg tcaaacagtg 29521 ggcgaattta aagcaggctg tttgaatatg ttttttcgct ttgacaaaca taatatttct 29581 agtacatgta atttttttat aaaaaattaa ttggcaaata aattggcaaa tttaataaat 29641 aatatcatgt cttgtaagtt attgttatta acaaaaaaga ttttctatgt tataatttaa 29701 attagaagga aaatagttat gacaaagaca tcaagatttt tccattttta taatgtaaat 29761 tgctttctac tgtaatatgt gcctgaaaaa caccatggca tttccgcttt atgactaatt 29821 tttatgtgtg cctgcctgta gttttacaag ctgtcctgtg tttatatttg ctttgcgtaa 29881 tggcagacaa aaattgtcat tttaatttca cttaaaactt gtaatgtata ttcgacaaat 29941 agacgatgat tttctagaaa tatatttact tgcgccaaaa ggggtaggga gaatttatga 30001 aaaacaggtt taaaggggta gggagaattt atgaaaaaca ggtttaatat aagagaggtt 30061 ttcagtaaaa tcaaaacttc tggctttaaa aaaataaaaa gattaaaaca ggcgattgca 30121 tcgaaagtgc gctttttaaa aagtttgaac gaaaaaaaat caagtgaaaa aaatattttt 30181 atgcctttct tcaggcttaa agatgtaagt ataggaatta aactcaatgt aattgtatct 30241 attgttcttg tagtatcttt gtctgtagta attttgtact cttttggcat tgtaaggaat 30301 atccttgtgg agcaggcaaa ggacggaacg ctgcaggttt caaagcaaac caattcgaat 30361 atgcgaatgc tccttgaatc aatggatcag gaggcaacgg ctttaagcag aaatgaacaa 30421 atagcggata ttatttcgag gttgaacagt actgatgatg ctactttaca aagcagatac 30481 tcgagtcagt taagaacgat gctgactaat tatgtggacg aaaaaagtaa ctatttttac 30541 actattctgg cggtttccaa taactaccta tattcgattt ccggacagca aataataagt 30601 catcagataa atataaaaga agttgacagt ataaaatctt ttgttgaaag tacgaaatat 30661 tcaaaatggt atgatcctta cgtgcaagat gttttaattc atcaggacac aaccggtttg 30721 ggcggaaaag taattacttt ggctaaaaaa gtttattcaa ggacaaagct aaaaagtccg 30781 gggcagctgt tcttctatat caactatgaa aatttgggca gaatatttaa tgatttgcat 30841 ttgccttatg acggggttat gtatgttgtc ggaaacgact ataacattgt aatgaatcct 30901 tcaaaaaaag aacacatgtc gctggctata aatgatgtta gccaggaaga aaaagaacgg 30961 aatttttata ttgacgaaga gatattcaag aaaattaaat cagaaccgag cggtgctttt 31021 acaacaaagt tgtatgggaa agatgttttg ataacttttt caacaataga taaagtcaat 31081 gttacggatt tgggatggac ttttgtaacc gttacggaag tagataagat tacggaaagt 31141 gtcaacagag tttcggcaca ggtaataatt atcggtttaa tttgtttggc gctggggata 31201 ctgttatctc aattaataaa taaagacatt acgaagaata taaagaaact ggtaaaaaca 31261 atggagaaag taggcagcgg taatttatca atagagttta aagttgagga gagaaaggat 31321 gagataggca agcttagtaa cagttttgca aagatgataa gcaacttgaa cggattgatt 31381 atgagtgtta aacatgcttc ggatgtcaca attgacgcat cttccaatgt atccgcaaaa 31441 attcaggaaa cgtatgcttc tattcaacaa acaaatgcta ttttggacgt tataaaggaa 31501 aagagttttc aacagggtaa gattgtaaaa gaaggtgagc gacaggttgc cttgacaaaa 31561 gatgaagtca atcaggcaaa agacacgatg aaagatgtag atgcgatact ttccaagtca 31621 aaagaaatca gcgaagataa tcgaatgtca gtaagcttgt tgcatgaaat gtctcaaaat 31681 atcagaacag ctatgaatga aataggtgcg gaatctaaag agcttattgc aacttcaaag 31741 gaaataacaa aatttacaag acagatcaaa gagatttcag aacaaacaaa attgattgct 31801 ctgaattcag ctattgagtc agcccgattg ggagcccagg gaaagacatt ccatttgtta 31861 tctgaagaaa ccagaaactt ggcttcaaaa accaaagatt tgtcgggcag catagaccag 31921 ataattcaaa atcttattga aaagattaac aataccaaca aggttgtatt aaagttggac 31981 aaagtggccg agaataccga aaattcggta aaggacgtaa cagaaagtct ggataaaaat 32041 attgaatttt taaatgagat aacatcaaat gtctctcgga taaaacaggt atttacgcac 32101 atagacgact ttgtcaatca gatagtatct acgatagaat atataagcgc aagtgccgag 32161 gcgaatattc aagacatttc tgatgtaagc aaagcgatga acgagcagat aaagtgtcag 32221 gaatcattat tggagcagac caccaatttg cttaacttgt cacaggagct caagaaaaaa 32281 gctgaagaga tatcctgatt cggtaaaagt attttagatt aatacggttg aaggtcggtt 32341 atacggttaa tttcagggtt aactgcccga gtcggtaagc gggcggttaa ccctgttgtt 32401 ctgtattatc tatgttgact tggttataat tgtatgttaa tatttattct ataagttggt 32461 acatgcagtg tttgcatata atttgtattg agcttgcgac agattataaa tttgatgttt 32521 ttttattaat ttttattgat gtggagggaa aagcatgttt aaagcttgtt tggcaaaaac 32581 aatgggaaga gtgctcacct ttctggcttt tttaacagtg atttcaattg gagccttttg 32641 cagctatgca gccgacactg ctcaaactga ttccagaacg gttgttactt cagactttat 32701 tgatttgaag tttactatta acaaaaagaa ttacatttcc aaaactgttt caaaggatct 32761 tgaggttgct ccttttatat ccaatggaag aaccctggtt cctttcagag caatttttga 32821 agagcttggt tacactgttg attggaatga cgcaaccaaa accgttaccg caaaatacaa 32881 aggaaatgaa ataaaactta ccgtgggtgc taacaaagca gttgtaaacg gctatgaagt 32941 tcccttggat gttgcacctg caatagtaaa ttccaggact gttgttccgc ttcgatttgt 33001 agctgagaat tccggctctt ttgttgactg gaatccggag gataaaacca tttccataaa 33061 aagaatcggg aaatttaata caggtactat tcttttctat gaccaaaaag gtaagaaccc 33121 tatggtatat gtttatgacg ggcagacaat cagttccata tcccttaagg gaaatgaaat 33181 caaaaatgcc attacctata acggtggtct tcttataacc cttttcgatg tggaaaatga 33241 tacaaataat cttgttacat acagaaacgg taaacttgaa gttcttataa gcaattttga 33301 gataaaagga caggtggagt tcaacggaaa ccttctgttg catggttatg acagaagaca 33361 aaagaaagac agtctttaca gatttgacgg caaaaatatt tatctgattg cagataattt 33421 tgcaatggga cattacgtca tctttaatga taaactggta atcaacaaat atgatgattt 33481 gagaagatat tctttgctgg tctttgacaa atcttcatgg aatccgaaag tattgaggga 33541 tggttttatt atcagggaga cgctaataga ggacaatgta cttttcatta gtggagacag 33601 ctctgtggga aataccaagc cgtttatatc ttatgatggc actaaagttc aagttttatc 33661 tgaagatctt gatattgatc ttaagaagac tgtgcaattt aaggataaag acggtataaa 33721 caacatagtg acggtagcta aaaaaggcag tacaggctat tttctggtat tgaggaattc 33781 aataaaagaa ccgacggagt atacaattta tgatctcttt gctccgactt ccatatttca 33841 atctgccggt gtgaaaccgt cggccgtaaa agttgatggt attgtagatt acaacggtaa 33901 gatttttata gctgtaaatc agacaaaaag cataattacg gcaaagtcat tcaggaccac 33961 agatgttccg tcgtatataa aaagggaaaa cttgtttaca tatccaaata ctcggtgttt 34021 ggtattgtca gatgttgaaa cgatacatag cggtgtgacg tttttaaact ttataattga 34081 agatgataat ttgctgatgc atttgcaaaa caaagatacc aaagactatt tgcttcatat 34141 atatgacaag gacaaagtgt ctacggctca tgacgtagtc aaaataaaca acattataac 34201 ggttgggcag aggacattta tagcagttga ggatattgac agaataaccg agaagaagag 34261 acaggctttg ttgatatatg atcagaatgt ttcgtctcct aatttgagaa tcagaaacct 34321 ggtacttgga atggagacca aagcatggga cgaattgaat ggaagtctgg ctataagcgg 34381 taatgaagcg gatataaaga gaaacaaagt ttatctttat tcaaatgagt ttaaggagct 34441 gttgagcaac ttccaggtca attactggga aaaaattggc gatcttatat ttacatcagg 34501 agttgatacc gacaccaaag tggattcctt ccattgcata aactccagaa acagcgagct 34561 tttaagggat tattttgacg ttgacaaagt tgtaaaggca aaaggtgact actatattgt 34621 gtacggaatt gagaaggcac caaagacaaa atataccaat aaaaagattc tgtatattta 34681 taatttcaga accaaggaat ttgtcgactt ggtagtagac ttccagttga ctgatatatt 34741 gtttattaat tagttgtgtt aacttaaagc tgattaaatt ttataaagcg gtcaaaaggg 34801 agtatccttc aaatggatat tcccttttca ttatgcctgg taaactaatt attggcgttt 34861 taaagggatt ttgagttgta atatcgaatt ttattataat atcaaatttt taatgctaaa 34921 cgtccagctg aaaattttct gccacgccgc attaattttt ttagaggtgg tatatttgtt 34981 tgaacccaac ttgatatatg gagtaaaaaa aagggagaaa aagtctcgct ctgactctat 35041 aaatcacatt attataaaga taaaaaacgg agatatcgaa ttaaaggaaa aatttataaa 35101 aaagtataaa ccgtatttat taaaaattat atccagcacc cttggaaggt atgttgatcc 35161 agaggtgagc gaggaataca gcgtaggact tatggctttc aatgaagcta tagatgggtt 35221 taatcctgag ataaatggca attttacgaa ctactgcaat atggtggtca atcatagaat 35281 tattgattat ataagaaaaa acaagaaata cagcaatgtc atacctttct catattttga 35341 agaaagaaac gatttcgaag aaaaatatct cgtctccgac agccattacc tttatgaaaa 35401 catagaagta aaagaggaaa ttctgcaatt tgaacagcag ttgaaacagt ttgggataac 35461 ccttgaagac ttggttatga actcaccgaa acacaaggac tcaagggaac tttgcatcag 35521 catagccaga attttatcag aaaatgacaa gctgtttgag aagatgattc gaaaaaaatg 35581 tattcccctg tctgaattaa tgggattggt taatgtccat cggaaaaccg tggaaaggaa 35641 caggaaattc attattgcag tgagtttgat tttaagaagt ggtcttgatg agataaagca 35701 gtttttcaga gcatctgagg aaaggaggga aaaataatga atcttggagt ggtaataaaa 35761 ataaaaagga agaaggccat aattgttacg gaaaccggcg aatttaaagc tgtaaatgcc 35821 agaaacggta tgtttttggg acaaaagatt ttatttgatc agcaagatgt tattgaaaat 35881 aacagaaatg gcattggtct tgcatattct gcagctatag cgggaatggt tgctgttttt 35941 gtattcatgt ttacatattt cggcttgcat aattttaatg gcacttttgc atatgttgac 36001 gtggatataa atccaagtgt cgaatttgcg gtaaacaggg acggtattgt tgtaaatgcc 36061 gaaccgctta atgatgatgg gagaaaagta ctggaagagt tgatatataa agatgctttg 36121 ctggaagatg tgattttgga tctggttgac aagtcgagaa agtacggatt tatagaagat 36181 aatgatagga agaatatcat attgatttcg gcagcgttaa acagtgatga gcaggaacaa 36241 agaaatgact ttgaaaagaa gctggttgac aatttaatgc cggaacttga gaatttggat 36301 gtaaatattg aaatgaggtt tgtcattgcc tcaaaagagc aaaggaagaa ggcacaggaa 36361 aacaaagtgt ccatgggtaa gtatatgatt tatgaaatgg cgagacggca aggtgaaaaa 36421 ctgactttgg agtcaattat gtcagaaaca ttggaaaatt tacttttggg tcaggacttt 36481 ggtgtaattg aaactgagaa aacacctgtg aatacaccgg ttaaatctac tgctactccg 36541 acgaaggcgc tggctgccga gattactccc acaaagacac cggaacaggt tgtgatgacg 36601 cctgcaaata cgccggctaa gcctacagct gctccaacaa aggcaccggc tgctgtggct 36661 gtgacctcgg caaaaacacc ggaaagagct acgacagtgc ctgtgaatac accggttaaa 36721 cctacggatg ctccgacaaa atcaccggcc actgccacag caactgcaac cagggcacct 36781 gtaaaagcta cagcaacacc tgcgaagaca ctcaaaccat cagacactcc tgtaaagacc 36841 ccggatggtg agcagagtgt caaagtgagg ttctacaaca ataacacttt gtctgaaacc 36901 ggtgtaattt acatgagaat aaatgttatt aacaccggaa atgcaccttt ggacctttcg 36961 gatttaaaac taagatatta ttacactatt gacagtgaga gtgaacagag attcaactgt 37021 gattggtcgt ccattggagc tcacaatgta acgggaagtt tcggaaaggt aaatccatct 37081 cgaaacggag cggatactta tgttgaaata ggatttacaa aagaagctgg aatgcttcaa 37141 ccgggcgaaa gcgttgaact taatgcgcgc ttttcaaaaa ctgacaatac acagtataat 37201 aaagcagatg attattcatt taattcccat tattacgaat atgtagactg ggacagaatt 37261 acagcgtata tttccggcat tttaaaatgg ggaagagaac catgattggt tccagtgaaa 37321 cttatttatg tcaacaaatt taactattaa aatatgttaa caaaattttc taaaggaggt 37381 aatagaattg agaaaggtta aggccttgtt gttgggattg attgtattgg ctgtagcttt 37441 gttacctaca gtgtccttta agtcaccgac tgttgcggcc gatccgaaca atgacgactg 37501 gctgcatgtt gaaggtaaca aaatagtgga catgtacggt aatcaggtct ggctgaccgg 37561 ctgcaactgg tttggattca ataccggtac caatgtgttt gacggagtat ggagctgcaa 37621 tatgagagaa gccctcaagg gtatggcgga cagaggaata aattttttga gaatacctat 37681 ttcaacagaa ttgctgtatc aatggtctca aggaatatat cccaaagcaa atgttaatga 37741 ttttgtaaat ccggagctga aaggaaagaa cagccttgag ctttttgact ttgccgttca 37801 gtgctgcaaa gaattcggaa taaagataat ggtggatata cacagtccgg caacagatgc 37861 catggggcat atgtatcctt tatggtatga cggtcaattt acaacagaga tatggatttc 37921 aactttggag tggttgacgg aaagatataa aaatgatgac acaattcttg cactggacct 37981 taaaaatgag cctcacggca ccccgggcag cgaattaatg gccaaatggg atggttccac 38041 ggatttgaac aactggaagc atgctgctga aacatgcgca aagagaatcc ttgcaataaa 38101 tccgaatatt cttattgtgg tagaaggagt ggaagtttat ccaaagcctg gctatgatta 38161 taccgcagtg gacgaatggg gaaaagagag taaatatttc tataactggt ggggaggaaa 38221 tttaagagga gtcagggatt atcccattga ccttggcaag catcagaagc agcttgtata 38281 ctcacctcac gattacggtc ccctcgtaca taaacaacct tggttctatg aaggctttaa 38341 caaagaaact ttgtataatg attgctggag agataactgg gcatacatac acgaggaaaa 38401 catcgctcct ctgatagtgg gtgaatgggg aggtttcatg gaccgcggag acaacgagaa 38461 atggatgaaa gcgctgagag attatatgat tgagaataaa atatcccaca ctttttggtg 38521 ctataatgca aattccggtg ataccggagg acttgtatac tatgatttta ttacctggga 38581 cgaagaaaaa tatgctcttc tgaagcctgc attatggcag acagaggacg gaaagtttat 38641 aggccttgac catcagatac ctcttggttc aaatggaatt accgtaactg aatattatgg 38701 cggctatatt ccggaaccgt caccgactgc tactgttcca gacgtaccga caccgtcgca 38761 ttctttcgaa atagagaagg gggatgtaaa cggtgacggt aatgttaatt caacagatgt 38821 tgtatggctt aggagatttt tgctaaaatt ggtcgaggat tttcctgtac cttccggaaa 38881 acaggcggcg gatatgaatg atgacgggaa tatcaattct accgatatga tagccttaaa 38941 gaggaaagtg cttaaaatac caatataaag agtatgacaa tataaacgtg catttattgt 39001 ttttcaacca ggtatttcca atacttttgg ggcatgtttt gcttttgcag ttttggattg 39061 actctgtcct ttatgcagat gctgttgaaa taattcttcc ataattcttc aaattggtcg 39121 tctgtctttg cggattggta ttgaagctct gcgggaaggt ctgtaaaaac acatttcgac 39181 gtattgtata cggcggcaaa gtttcttttg gtgtcgtgga ttatccaaaa ttgatcggac 39241 agacgccgta caaaatggtc ggatattaaa acggtaatat tgtagacagg gctgtagggg 39301 gcatagtaaa ggcccccttt caacttttta aacctcagca aacccagcat aagatggctt 39361 tccgtccgta cttttttagc cgcggaatga acctttagca cttcttcgga agtaaggtaa 39421 aggtccacgg attttccctt tttaaagcca atccttaaat atctgagtat gtaagtatca 39481 atattgtcaa gttctgacaa gtaagcgtgg taaacatttc tcaaggcgtc atatgaaatt 39541 ttttcgcata ttgcttcata gactttagag gctttttcgc tgtcagtgac aatatcaata 39601 tttttatcca aaatgctttg ctgcatgttt tttgagcgaa aaatccggtc tggaggttca 39661 acaccgtaat atgactcgta tacacaagtc aaaagtccgt caaaagttcc gtcatagtaa 39721 tagtgtatca ttgcatatca cctatatatt tcctgtataa ttatatttct ccggttatgc 39781 tcattatttg gtcttgaaga gtcggttttt ccggtattag agaaaaaatc gaaatttgct 39841 cccattcctg ccttttttca ttatcttcaa aaccattaat caggttttgc cttattaaat 39901 tctgatccaa gttacagttg aaaaaatact tgccattaca ggtaatgaag aattttgcac 39961 gttttagaac gacaccaagt ttttttaagt cttcgaagga taatgattta acttttcttg 40021 ccataatgat ttttttggca gagcgaactc cgatgcccgg aactctaagc agcatttcgt 40081 agtctgcgcg gtttatttca acaggaaaga gggacatatt gttaattgcc cagtttgttt 40141 ttgggtcaag tttggggtca aagtcgggat tgcgctcatc aaggagctcg tccgctgaaa 40201 aaccgtaaaa tctcaaaagc cagtcagcct gataaagcct gtgttctcta agaagcggag 40261 gagtctttaa atcgggcaga agcggatttt tggatacagg tacatatgcc gaataataaa 40321 ctcttttaag tttgtatttt ttgtacaggt tttcagaaag cctcagaatg ttgatatcgt 40381 ggtcctgggt ggctcccacg ataagttgag tactctgacc tccgggaaca aataaaggtg 40441 catttttaaa tacctttctc tcatcccttt tttcggttat cttggatgct ataaaattca 40501 ttggcttaag tatcgcctgt ttattttttt gaggggccag aagcttaagt ccgttttcgg 40561 aagggagctc gatgttgaca ctcattctgt cagccaattt tccgacagct tcaatgaggc 40621 caaggtcagc acccgggata gccttgacat gtatgtagcc gttgaatctg tattctttcc 40681 ttaaaatcct tagcgattca taaaggagct ccattgtatg gttgggattt tttaccactg 40741 cagagcttag gaacaaacct tcaatatagt ttcgtctgta aaagtttatt gtaagatttg 40801 ccacttcttg gggtgtaaaa gcagctcttg ggatatcatt gcttactctg ttgacacagt 40861 aggcgcaatc atacacgcag taattggtaa gaaggatttt taaaagagaa atacaccttc 40921 cgtcatcaga ccagctatgg catataccga aagatgctgc gtttcccagg cctcctttgg 40981 tattttttct gttgctgccg ctggaggaac acgaaacatc atattttgcg gcggcggata 41041 atatttcaag ctttttttga agctccacta aaatgcacct cccgaaagtt gctaaataaa 41101 ttttaccaca agggaaaaat aaagcaaaca tttgttcggg atattatatg caaattagac 41161 cagatttatt gaaaataggt tgaaaaaagt atgtaaaatt atatataata taattatata 41221 gtccttatta tgtacagctc aaaaagctgg ggttatttgg ttgagtttta cgtgtcgctt 41281 ctatattcaa gcattacagg tccaacattg tttcgtgtga attttgcatt ttacaatttt 41341 taatccgggg gaagaagatg aaagtcaagt gttttggaat aaatctttgt gttttttcac 41401 tacttctgat attttgtcag gttgtttatg ctaaaactga cacgattatt tatgaaacag 41461 agttatacgg tcctccgttt aagttcatag aggacggtga aatatcgggg tttgaaatcg 41521 aactgaacca gtacatattt tcaggcagtg aatacaggtt tgattatagg ttcaacacct 41581 gggaaaaagt ttatgaaaaa ctaaaaaacg gagaaattga tacctgtggt cttcttgttg 41641 taaatgaaga aaggaaaaaa gacatattgt tttccgatac ggttatgaat atttatattt 41701 ccatttattc caaggaaaaa aataagaata ttggaataaa agatcttgag aaatatcgtg 41761 tgggtgtggg aaaagagcaa tacagtgagc atattttgaa agacagtgtg ggcattagca 41821 attacacaac ctttgtggat gtggaagaag cgatagatgc tttaaatgag ggaaaaattg 41881 atgttatttt tgaaaatcag gacgtcgtaa atcattattt gattaaaaaa ggtttaaccg 41941 gcaaaataat tccccacaaa acggagcttt ttcccgtcaa agttgcttac ggtgtgagta 42001 aaagaaatcc cgaacttgtc aaatatatta atgaacgact ggatagtgtg aaaaaaaacg 42061 gtatatatga acagctttat agaaagcatt tcctgcggcc ttcagatttc tacagaagaa 42121 aacagagaat cagaaatttt gccgcaatgc ttgcactgct tgtccttttg gcacttttgc 42181 aagtttatat aaggcacctt aagaaaaaga tatcaaaagc ataccgtgaa cttcgcaaac 42241 agcatgaatg gctgagaata acgctctcaa gcattggaga ggcggtaatt acaacggatg 42301 aaaacggaac cgttactttc agcaattatg aaattcaaaa gatgttgggc ctttctgaag 42361 aagaaatact aggcaagaaa ttggacaagc tgctttcggg attggtggat aaaagggaaa 42421 aggtttataa aattcctatt gaagaagttg taaatcgggg tagcatgata aaacttgaga 42481 ctgatttgag tcttgtaact ccgggtggga gaagacttgt ggagggcact gtcgcaccaa 42541 taagaaatga ttcggatgtg atcattggga cagttgttgc attaaaggac attacggaaa 42601 taaagaagaa agatgaaatc ctgtacaaca tggagtatta tgacccgctg acagggcttc 42661 ccaacagaag tcttttttcc gaccgcctta aaatggctct tgcccagtcg aaacgcaata 42721 atgagatgtg tgcgctgatt atattggatc ttgataattt taaagcaatt aatgatacac 42781 tggggcactc cgtcggagat atgcttttaa agcaggtggc tgaaaaaata aagggttatc 42841 tgagggaagt tgataccgtt gcaagaatag gaggagatga gttcataatt attcagcctc 42901 aaataaaaga tataaacgat gctaccagag cagcggacag aatattgaaa aaatttcagc 42961 aaccgtggat cttggaaggc aaggaatatt atataactgc cagtatgggc atcggcattt 43021 accccaatga cggagaggat ccgcaaacta tttttaaaaa tgcggatacg gcattataca 43081 gagccaaaga gctgggaagg aataattatc agttatatac cgagtcgatg aaccaaaagg 43141 tccttcaaag gctggatatt gaaaatagct taaggagagc aattgagaag gaagaatttg 43201 tactgtttta tcaaccacag atcgatatca aaaccggtaa gattgtcggt tttgaagcgc 43261 ttttgagatg gtatcaccct gattatgggc ttatgcctcc catggaattt atacccgttg 43321 cagaggattc agggcttata gtggttattg gggaatgggt tcttgaaact gcgtgcaggc 43381 agaacaaaaa atggattgag tgtggattgg agccgcattt gatttcggta aacttgtctg 43441 caagacaatt tcaacgttca aacattgttg aagtgattga cagaattcgc agtagcaccg 43501 gtttggcacc ggagcttttg gagctggaaa taacggagag cactgcgatg caagacttga 43561 gttttacaat agatgttttg aatcagttga ggaaaaaggg aataagggtg tcccttgatg 43621 attttggaac cggttattca tcactgaatt atttaagaca gcttcctata gatactctca 43681 aaatagataa aagttttgtt caggacataa gggccaactc aaaagaagag gctattgcta 43741 aaaccgttat cagccttgct cacaagcttg accttactgt tgtggcggaa ggtgttgaga 43801 caaaagaaca acttttattc cttaaaaagg agaagtgtga caaggctcaa ggatatcttt 43861 tcagcaaacc gctgccggca gaggaaattg aaaaaatgtt aagagataaa aaatgttttg 43921 tcatcggcga ggaagttgac aactgatttt acggtattga tattataacc tcccgatagt 43981 ataatactct ttataagagg gaggtaataa ggatgagagc ggttatcact gttattggaa 44041 aggacaaaat aggtatcatt gcgggtatca gcaacattct tgccgattgt aatgtgaaca 44101 ttttggacat ttctcagacc atcatgcagg acgtttttac catggtgatg cttgtagata 44161 tatccaaact atgtgttcag tttgcggagt tggctgaccg gcttgagaaa aagggtgttg 44221 aaatgggact ttcagtaagg attcagcacg aagatatttt taattccatg catcgtatat 44281 aagggggaaa attcaggtgt taatgccttt tgaaataatg gaaacaataa agatgatcca 44341 ggaggagaat cttgacataa gaacaattac gatggggata tccttaaggg attgtgccag 44401 ttccaattca aaagagacaa gggacaaaat ctataataag attaccagac ttgcggcaaa 44461 tcttgtaaag gttggcgagg atatagaaaa ggaatttggt attcccatag taaacaagag 44521 aatttccgtt actccgattt ctcttgtggc cgaaagcagt gacgaagaaa attatataaa 44581 gtttgccgag actttggaca aggccgcaga tgccgtcgga gtcaatttta taggcggctt 44641 ttctgcgctg gttcaaaaag gctatactat tggagacaga agacttatag catcgatacc 44701 ggaagctttg agcagtacga aaaaggtttg ttcatctgtc aatgttgcca gtacaaaagc 44761 gggaattaac atggatgcgg tcagggagat ggggcatgtt ataaaaaaag ctgcggaact 44821 tagcgctgac agtggaggtt tggcatgtgc caagcttgtt gtttttgcca atgttcccga 44881 agacaatccg tttatggcgg gagcttttca cggagtagga gaaccggaat gtgttataaa 44941 tgtgggggta agcggcccgg gagttgtaaa atccgccctt gagaaagtaa gaggagctga 45001 ttttgaaacc gtttcggaga ctattaaaaa aactgcgttt aaaataacca ggatgggtca 45061 gctggttgcc cgtgaagctt caaggcgtct tggggttgcc tttggtatag ttgacttgtc 45121 tcttgcacct actccgacca taggggacag tgttgctcat attttggagg aaatggggct 45181 tgaaaagtgc gggactcatg gaactactgc cgctttggca ttgcttaatg atgccgtcaa 45241 aaaaggcggt acgatggctt cctcttccgt tggcggtctg agtggtgctt ttattcctgt 45301 aagtgaagat gcgggtatga ttgatgctgt caaagcgggt gcacttagca ttgagaagct 45361 tgaagcaatg acgtgtgtgt gttccgtagg tctggatatg attgtagttc ccggagacac 45421 gagcgaggag actatttcag ctattatagc cgatgaagct gccattggag taatcaataa 45481 caagaccact gcagtgagga taattcccgc accgggtaaa aaagtcggag atattgttga 45541 gttcggaggt ctcttgggct cgggtccggt aatgaaagtc agcaatttca gcagcagaga 45601 ttttatcaac agaggaggaa gaataccggc acctcttaac agtctgagaa actaattttt 45661 aatcctgaaa accattttaa aaaatcgttt ttataatgag ccgaagagta cactaaaaag 45721 cgttcgtgga aatgatacaa agcttttttg gaaagttgca taaaagtcag ttgtacaaaa 45781 agcaaaaagt ctgattttgc cccatatcag acttttcttt tgcttttaaa ttttgcatct 45841 cataacacag acgctttttg atccaatatt ctgccagtat tcaatatagt cattgtcctg 45901 tctgaaatta ctgaaagaat agccgttttc ctgtacatat tggaaaatgt catttgtaaa 45961 cagaacgtcc catgcttctt cattaacatt tggaagttct gtcaacgtaa attcattgga 46021 tatatttttg agctcgtcga acaaaagaac tctgtaactg tcgttacctt ccttatataa 46081 ggcataatgg tcttgaactc ttattatatc ctcggtttta atttttcttt cttccaggag 46141 tatagtctgc aactttttgt tctgataaag aaatttatga caacctatat aatttaaaac 46201 aacttttaga ttgttgtttt gctttaaatt ggcaagactg attttgagaa catccggagt 46261 atcattttta aaggttacaa ttattgcttc agagtcagcc agataccaga tttcattctt 46321 gtccatgtaa ataatttgtt cgggcagact gctctcatta tattttgggt aaagaaatgg 46381 atgtgcatta tgaaatttga tggtcttgac agaaatattg tctgcttctt ttatagttac 46441 agttttaggc tgaccttgag aatctttatc aataatgacg acttttccaa aatcagtaca 46501 atagacataa ttgaacttgc tggatacaac aagatctttt ttactgagat ttagtatatc 46561 ttccaggttt ctaagcctgg ctcttttcaa agaatagggt aagccggaag gtttctcgga 46621 attctgggat atactttcgc tgatattatt tttaaggctt tttgtcgtat tcgaattaaa 46681 acccttgact ttttcatttt gaagggagga aacttttgaa gatattatat ccataagacc 46741 tttaatactg tttccgactt ctttgattcc accgtcgtct ttgcgtttgt ccgatgatgg 46801 ccttgatgat gcaaaacggt attcttccgg taataagttg atgtccttct tattacccat 46861 acaaatcact cctttaaaaa gcattgggtt tgtaacacag tgcccgtaga taagatgata 46921 acatgaaaaa caaaaccaat atcaataatc cgtgcaaata taaaactata tctctccaat 46981 acaaaaatgt tgcagaatgc agcgttaaaa ttctctaaca catttttact tattgataat 47041 tataccatat ctttgcttta tagtacatta tttttaagtt aattattatt taaaaaaccg 47101 atattaaaaa gaagtaattt gtgagtaatg ataataatat aatgtaaaat gccatacaga 47161 atgtaatgtt gtaatgatgt aagtacaaat tttgtttcca aaattctata aaattatgtt 47221 ataaattcta taaaattatg ttatagtcaa gccaaggttt tgatttatat cttcctttga 47281 ttttaaatta aaattgcaaa aaagacttga catttgacgt atatagaaat atatttaaaa 47341 tatacgatac tgttttttca aatagtataa tttggggttt aggggtatct tcttacaaat 47401 tggcttgttc gtaccaatgt atctgtttat ctttaaagta gttttcctat tatttattca 47461 atactcaatc catcaaaaaa tactcctcat tcagtactac ttattcggca taggttaatt 47521 ttgtaaataa tttaaatatt ttaattgttt taagttgtta aagtgaagct taaagctttt 47581 caaactaata aataaaaaca ctgcaaagga ggtgtactct tatcagaggg ctgtaaaacc 47641 ctgtatttat tagtttgatg gtaggtttaa taatttgttg cattttttat gatattcgac 47701 agaaagaaaa aagagtattg taaagaatgc aacggaaaag cttcattttc taatgcttta 47761 aattaattaa cgggaggtag atttatgaat ttcagaagaa tgttgtgcgc agccatagtg 47821 ttgacaattg tactgtccat tatgctgccg tcaactgttt ttgctttgga agacaagtct 47881 ccaaagttgc cggattataa aaacgacctt ttgtatgaaa gaacattcga cgaaggtctt 47941 tgctttccgt ggcatacttg cgaagacagt ggaggaaaat gtgatttcgc tgttgttgat 48001 gttccaggag agcctgggaa caaagctttc cgcttgacag taattgacaa aggacaaaac 48061 aagtggagtg tccagatgag acacagaggt attaccctcg agcaaggaca tacatacacg 48121 gtaaggttta cgatttggtc tgacaaatcc tgtagggttt atgctaaaat tggtcagatg 48181 ggtgaaccct atactgaata ttggaacaat aactggaatc cattcaacct tacaccagga 48241 cagaagctta cagttgaaca gaattttaca atgaactatc ctactgatga cacatgcgag 48301 ttcacattcc atttgggtgg agaacttgct gcaggtacac cttactatgt ttaccttgat 48361 gatgtatctc tctacgatcc taggtttgta aagcctgttg aatatgtact tccgcagccg 48421 gatgtacgtg ttaaccaggt aggatacttg ccgtttgcaa agaagtatgc tactgttgta 48481 tcttcttcaa ccagcccgct taagtggcag cttctcaatt cggcaaatca ggttgttttg 48541 gaaggtaata caataccaaa aggacttgac aaagattcac aggattatgt acattggata 48601 gatttctcca actttaagac tgaaggaaaa ggttattact tcaagcttcc gactgtaaac 48661 agcgatacaa attacagcca tcctttcgat atcagtgctg atatttactc caagatgaaa 48721 tttgatgcat tggcattctt ctatcacaag agaagcggta ttcctattga aatgccgtat 48781 gcaggaggag aacagtggac cagacctgca ggacatattg gtgttgctcc gaacaaagga 48841 gacacaaatg ttcctacatg gcctcaggat gatgaatatg caggaagacc tcaaaaatat 48901 tatacaaaag atgtaaccgg tggatggtat gatgccggtg accacggtaa atatgttgta 48961 aacggcggta tagctgtttg gacattgatg aacatgtatg aaagggcaaa aatcagaggc 49021 atagctaatc aaggtgctta taaagacggt ggaatgaaca taccggagag aaataacggt 49081 tatccggaca ttcttgatga agcaagatgg gaaattgagt tctttatgaa gatgcaggtt 49141 actgaaagag aggatgcttc catagccgga atggtacatc acaagattca cgacttcaga 49201 tggactgctt tgggtatgtt gcctcacgaa gacccgcagg agcgttactt aagaccggta 49261 agtacggctg caactttgaa ctttgcagca accttggcac agagcgcgcg tctctggaag 49321 gattatgatc cgacttttgc ggctcaatgt ttggaaaaag ctgaaatagc atggaaggca 49381 gcactgaaga atcctgatat ttatgctgag tatactcccg gtagcggtgg tcccggaggc 49441 ggaccataca atgacgacta tgtcggagac gagttctact gggcagcctg cgaactttat 49501 gtaacaacag gaaaagacga atataagaat tacctgatga attcacctca ctatcttgaa 49561 atgcctgcaa agatgggtga aaacggtgga gcaaacggag aagacagtgg attgtgggga 49621 tgcttcacct ggggaactac tcaaggattg ggaactatta ctcttgcatt agttgaaaac 49681 ggattgccgt ctgcagacat tcaaaaggca agaaacaata tagctaaagc tgcagacaaa 49741 tggcttgaga atattgaaga gcaaggttac agactgccga tcaaacaggc ggaggatgag 49801 agaggcggtt atccatgggg ttcaaactcc ttcattttga accagatgat agttatggga 49861 tacgcatatg actttacagg caacagcaag tatcttgacg gaatgcagga tggtatgagc 49921 tacctgttgg gaagaaacgg actggatcag tcctatgtaa cagggtatgg tgagcgtcca 49981 cttcagaatc ctcatgacag attctggacg ccacagacaa gtaagaaatt ccctgctcca 50041 cctccgggta taattgccgg tggtccgaac tcccgtttcg aagacccgac aataactgca 50101 gcagttaaga aggatacacc gccgcagaag tgctacattg accatacaga ctcatggtca 50161 accaacgaga taactattaa ctggaatgct ccgtttgcat gggttacagc ttatctcgat 50221 gaaattgact taataacacc gccaggagga gtagacccag aagaaccgga ggttatttat 50281 ggtgactgca atggcgacgg aaaagttaat tcaactgacg ctgtggcatt gaagagatat 50341 atcttgagat caggtataag catcaacact gataatgctg atgtaaatgc tgatggcaga 50401 gttaactcta cagacttggc aatattgaag agatatattc ttaaagagat agatgtattg 50461 ccacataaat aaaaaactgc catataatga taatctgtta taaaaanaaa cgtacgttac 50521 gtttacgttt aacg //