LOCUS NZ_ACVX01000035 37617 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00064, whole genome shotgun sequence. ACCESSION NZ_ACVX01000035 NZ_ACVX00000000 VERSION NZ_ACVX01000035.1 GI:256005618 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 37617) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 37617) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000035. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..37617 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene <1..689 /locus_tag="ClothDRAFT_2438" CDS <1..689 /locus_tag="ClothDRAFT_2438" /inference="similar to AA sequence:KEGG:ABO_2709" /note="KEGG: abo:ABO_2709 aldehyde dehydrogenase (NAD)" /codon_start=3 /transl_table=11 /product="aldehyde dehydrogenase (NAD)" /protein_id="ZP_05430577.1" /db_xref="GI:256005619" /translation="LNAGQTCIAPDYVFVKKELLGDFVSHLKHYIKKYYYSDGSGRCS NYCGIINERHFNRLKNVFEVTVKEGAKVCEGGLFVENECYISPTVLTDVGRDSYIMEE EIFGPILPVLTYEKIDDVIEYINSKPAPLVLYVFSRDRKFYRHVINNVISGDCLINDV IAHFANPRLPFGGHNASGIGKSHGYYGFREFSHLRSIMIQPKRTMLQLLYPPYGEFVK KLIEWSTKYF" misc_feature <1..599 /locus_tag="ClothDRAFT_2438" /note="NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961" /db_xref="CDD:187156" misc_feature order(12..14,21..23) /locus_tag="ClothDRAFT_2438" /note="catalytic residues; other site" /db_xref="CDD:143395" gene 906..1727 /locus_tag="ClothDRAFT_2439" CDS 906..1727 /locus_tag="ClothDRAFT_2439" /inference="protein motif:PFAM:PF00700" /note="PFAM: flagellin domain protein; KEGG: pha:PSHAa0782 flagellin (FliC-like)" /codon_start=1 /transl_table=11 /product="flagellin domain protein" /protein_id="ZP_05430578.1" /db_xref="GI:256005620" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /translation="MRINNNIMAYNAHRQLKVNASAQEKSLEKLSSGYRINRAGDDAA GLSISEKMRAQIRGLQMASKNAQDGISLIQTAEGALTETHAILQRMRELAVQAANDTN VTKDRSAIQLEINELAEEVTRIAEKTQFNTRTLLAGGLKDDGAVTIQIGANKGETLSI EIGTMTAAKLSVSGLVVSTSAWAQSAISKIDAAINTVSTERARLGAKQNRLEHTIKNL DTAAENLQASESRIRDVDMAQEMMNFTKNNILNQAATAMLAQANMVPQGVLQLLG" misc_feature 906..1721 /locus_tag="ClothDRAFT_2439" /note="flagellin; Provisional; Region: PRK12804" /db_xref="CDD:183759" misc_feature 912..1328 /locus_tag="ClothDRAFT_2439" /note="Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669" /db_xref="CDD:144315" misc_feature 1464..1721 /locus_tag="ClothDRAFT_2439" /note="Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700" /db_xref="CDD:144340" gene 1800..2618 /locus_tag="ClothDRAFT_2440" CDS 1800..2618 /locus_tag="ClothDRAFT_2440" /inference="protein motif:PFAM:PF00700" /note="PFAM: flagellin domain protein; KEGG: neu:NE1593 flagellin" /codon_start=1 /transl_table=11 /product="flagellin domain protein" /protein_id="ZP_05430579.1" /db_xref="GI:256005621" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /translation="MRINNNIMAYNAHRQLKVNASAQEKSLEKLSSGYRINRAGDDAA GLSISEKMRAQIRGLQMASKNAQDGISLIQTAEGALTETHAILQRMRELAVQAANDTN VTKDRSAIQLELNELAAEITRIGETTQFNTQKLLDGTFSARVLQIGANKGETLSIEIG DMTATALHVNADNLSVETSEDAQDTIELVDQAINIVSGERAKLGAKQNRLEHTIKNLD TAAENLQASESRIRDVDMAQEMMNFTKNNILNQAAIAMLAQANQVPQGVLQLLG" misc_feature 1800..2612 /locus_tag="ClothDRAFT_2440" /note="flagellin; Provisional; Region: PRK12804" /db_xref="CDD:183759" misc_feature 1806..2222 /locus_tag="ClothDRAFT_2440" /note="Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669" /db_xref="CDD:144315" misc_feature 2355..2612 /locus_tag="ClothDRAFT_2440" /note="Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700" /db_xref="CDD:144340" gene 2724..4628 /locus_tag="ClothDRAFT_2441" CDS 2724..4628 /locus_tag="ClothDRAFT_2441" /inference="protein motif:PFAM:PF01973" /note="PFAM: protein of unknown function DUF115; KEGG: dat:HRM2_36870 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF115" /protein_id="ZP_05430580.1" /db_xref="GI:256005622" /db_xref="InterPro:IPR002826" /translation="MVDVFRLNIDALKENYLPLARFFENLNENTGNESSVILETSKSG MPNFRVKKGEHTFFVHSPYDPRTEAIRWAEKIDLKGFDTIAVLGIGCGYHIEELEKKY PDKNKIVIEPDRNVFLKLLNTRDITHLISSKNILFIISDNTEEIAKVFLLLREEGEID SVEFNELLSYRKVYEDWWLELKKEYIKFARLHQINTNTSVFFAEAWLTNLFEGMWQLT KSVHIKEYKSAFANIPAIVVSAGPALNKNVHLLKELYNKAVIISAGSALNILESRGIT PHIMVGVDGGEAESRIFNNVKSNEIYFAYSLSVHYDGLKNYSGPKIYFKTNVLGYGDW IDEKLGIEGAENLRSGSSVSNLSLDIARYMGCNPIIVIGQNLSFPNLESYADGAVLKQ EQDRHIQQCVENSNKYYVLEKDIDGNDVYTTHSMLSIRFYFEEYIKNHPDRLYLNGSE EGLPIKGMKNMPLKEIVEKYCTKEYDIKGILDKKFKEEFEAENVKAKEIKIRRILEDI HKESTEIRQKAIKRIDLILDILSNIRGSHNDKWEEIDRLTDEIESSDLYKYFVEPLSK YFIQAVKNERERKMESIPDIQERLKYLYEGLLIQYVEVKDKIVLIDDLSQKIIENIDK KEATKCLSMV" misc_feature 2730..4538 /locus_tag="ClothDRAFT_2441" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604" /db_xref="CDD:32596" gene 4610..4993 /locus_tag="ClothDRAFT_2442" CDS 4610..4993 /locus_tag="ClothDRAFT_2442" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: dvl:Dvul_2524 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430581.1" /db_xref="GI:256005623" /translation="MSKYGLKKEIVGTAAEYIVNVSEGIDQIIEFFQSGREDIATRMM IDLIEGIEWLTQAIDGTRDIHGEYAMDVSQINSALHEISEAYENMDYVLLSDLLEYEL LPVINVWRKQLAGIKGVLDNDNAEE" gene 4974..6386 /locus_tag="ClothDRAFT_2443" CDS 4974..6386 /locus_tag="ClothDRAFT_2443" /inference="protein motif:PFAM:PF01973" /note="PFAM: protein of unknown function DUF115; KEGG: dat:HRM2_36870 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF115" /protein_id="ZP_05430582.1" /db_xref="GI:256005624" /db_xref="InterPro:IPR002826" /translation="MTMLKNNLELLKKRYPEIYNEIKDIHVDSNAYQIIQNNEGQKTL KVTLDLYGENKSFFLHSKYHPDVEADRFAREQYKPEFSIQILYGFGLGYHVEKIAGLL KPDSMLYVIENNLMVFRSALENMDLCPILENRNVSLIVSKDVGYISEKVKELIDNNLD KVSFITHPASLKAIPEENEYFKFVMENWNLKKSITDDYDNTLRNNAKENLKLNSPNVG IFFDKFKDVPIIIVSTGPSLDKNIDLLKEAKGRALIISAGSALRPLLMRNIKPDFFAI IDPQDITYNQIKGYENIGIPFIYLVTAASYTVSRYLGPKLVAYYGKYNNSSEHLVDSG GSVATTILDIAIKMGGNPIILVGQDLAYVDGKNHAQYGSHASIYSPELKNMRRVKGQN GEMLYTSLGLLSYKYWIENRIQKEKRIFINATEGGAYIEGMKHIKLRDVISDYLKESF DFENKIKSILKESGIQHVQG" misc_feature 5061..>6314 /locus_tag="ClothDRAFT_2443" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604" /db_xref="CDD:32596" gene 6373..7371 /locus_tag="ClothDRAFT_2444" CDS 6373..7371 /locus_tag="ClothDRAFT_2444" /inference="protein motif:PFAM:PF02719" /note="PFAM: polysaccharide biosynthesis protein CapD; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; TrkA-N domain protein; short-chain dehydrogenase/reductase SDR; dTDP-4-dehydrorhamnose reductase; NAD-dependent epimerase/dehydratase; KEGG: dal:Dalk_1657 polysaccharide biosynthesis protein CapD" /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein CapD" /protein_id="ZP_05430583.1" /db_xref="GI:256005625" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002225" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR013120" /translation="MFKDKKILVIGGTGSIGQALIERILTENPAVIRVYSRDEYKQFL LAEKFRENANIRYLIGDVRDEDRLDRAMNDIDIVFNLAALKHVPACEYNPFEAVRTNV IGSQNVIACAMANKVKKVIYTSSDKAVSPTNTMGATKLLAERLMSSSNYSRGNTGTVF ASVRFGNVMGTRGSVIPLFKQQVLEKGYITVTEPEMTRFMMSLSQAVELTIKACSIAR GGEVFVLKMPVIRLKDLAEVIIEDMCKKNNIDPEKIEIKKIGLRPGEKMYEELMSEDE STKAVELNDMYVIMPPFENSYYINARKAVIGNYSSQKEKTLTKSQIRELLVREKLI" misc_feature 6391..7245 /locus_tag="ClothDRAFT_2444" /note="Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719" /db_xref="CDD:145720" misc_feature 6403..6882 /locus_tag="ClothDRAFT_2444" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" gene 7498..8142 /locus_tag="ClothDRAFT_2445" CDS 7498..8142 /locus_tag="ClothDRAFT_2445" /inference="protein motif:PFAM:PF08241" /note="PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: cak:Caul_4739 methyltransferase type 11" /codon_start=1 /transl_table=11 /product="Methyltransferase type 11" /protein_id="ZP_05430584.1" /db_xref="GI:256005626" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR013217" /translation="MMTNLQEKTWAGQFGKDYTDRCTFSPEELDSLYKREYGISREEM NTRFLSGLGLENKRILEVGCNVGNQLRMLQRMGFNNLYGIELQQYAIEKAKALTKRIN IIHGVADDIPFKDGYFDMVFTSGVLIHISPGNINRVLDEIYRCSREYIWGFEYYADDY TEVNYRGHESLLWKTNFPKLYLDRFPELELVKEEKFKYLYNDNVDVMFLLRKRK" misc_feature 7669..7941 /locus_tag="ClothDRAFT_2445" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440" /db_xref="CDD:100107" misc_feature order(7681..7701,7750..7755,7813..7815,7816..7818, 7867..7869) /locus_tag="ClothDRAFT_2445" /note="S-adenosylmethionine binding site; other site" /db_xref="CDD:100107" gene 8174..8914 /locus_tag="ClothDRAFT_2446" CDS 8174..8914 /locus_tag="ClothDRAFT_2446" /inference="protein motif:PFAM:PF02348" /note="PFAM: acylneuraminate cytidylyltransferase; KEGG: dar:Daro_1245 aminotransferase" /codon_start=1 /transl_table=11 /product="acylneuraminate cytidylyltransferase" /protein_id="ZP_05430585.1" /db_xref="GI:256005627" /db_xref="InterPro:IPR003329" /translation="MKTGAVVQTRMGSTRLPGKVMMNLCGKPVIDHVIDRLKQSKLLD DIIIATTTSEKDKVIVEQAKKNGVKWFCGSEEDVLSRYYYAAKENNLDTVVRITSDCP LIDPVLLDKVVEFYFSGNYTLVTNAGNDLTQRTYPRGLDVEVFSFKVLEDAFNNADKS YQREHVTPYMYETYGQSVYYYKNNTDYSNLRWTLDTIEDFELIAIIYDKLYDKYNGKF GFEEVLEFIKSNPELCKINAHVEQKKVM" misc_feature 8183..8890 /locus_tag="ClothDRAFT_2446" /note="SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518" /db_xref="CDD:133011" misc_feature order(8195..8197,8201..8203,8471..8473) /locus_tag="ClothDRAFT_2446" /note="ligand binding site; other site" /db_xref="CDD:133011" gene 8972..10024 /locus_tag="ClothDRAFT_2447" CDS 8972..10024 /locus_tag="ClothDRAFT_2447" /EC_number="2.5.1.57" /inference="protein motif:PRIAM:2.5.1.57" /note="PFAM: N-acetylneuraminic acid synthase domain; SAF domain protein; KEGG: dat:HRM2_36740 NeuB" /codon_start=1 /transl_table=11 /product="N-acylneuraminate-9-phosphate synthase" /protein_id="ZP_05430586.1" /db_xref="GI:256005628" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013974" /translation="MQSRRIKIGNREIGEGCPCYIIAEMSANHAGDLGRAIEIIHAAK EAGADCIKIQTYTPDTMTINCDKKYFHINDGTWKGENLYGLYQKANTPWEWHARLKEE AQKAGIDFFSTPFDKSAVDFLEDLGVEFYKIASFEVVDIPLIKYIASKKKPIIMSTGM ATLGEIEEAVETIRSQGNDNFCLLKCSSAYPAVPEQMNLKTIAHLKETFNVPVGLSDH SLGSVSAVVAVAMGASIIEKHFCLSREIKSPDSSFSMEPDEFKKMVEDIRAAEKSIGK VSYSISENEAVSRSHRRSIFVVKDIKKGEAFTEENIRIIRPADGLEPKYFEQVLNRRA SQDIERGTPLKWTMIS" misc_feature 9023..10003 /locus_tag="ClothDRAFT_2447" /note="pseudaminic acid synthase; Region: PseI; TIGR03586" /db_xref="CDD:163337" misc_feature 9086..9802 /locus_tag="ClothDRAFT_2447" /note="NeuB family; Region: NeuB; cl00496" /db_xref="CDD:186036" misc_feature 9845..10018 /locus_tag="ClothDRAFT_2447" /note="SAF domain; Region: SAF; cl00555" /db_xref="CDD:186078" gene 10006..10617 /locus_tag="ClothDRAFT_2448" CDS 10006..10617 /locus_tag="ClothDRAFT_2448" /inference="similar to AA sequence:KEGG:Sden_1284" /note="KEGG: sdn:Sden_1284 MaoC-like dehydratase" /codon_start=1 /transl_table=11 /product="MaoC-like dehydratase" /protein_id="ZP_05430587.1" /db_xref="GI:256005629" /db_xref="InterPro:IPR000182" /translation="MDNDKLKDGYVNFINILNLDDMYVKKMREWRNQDFVRQRMFNRE IITEEEHARFIEHLKDNREKNYYVCFLGNKPFGVLYYEFFRKNNNLEFGYYLTEQEFI NSGLGIVMEYSLLNHAFYDLKVNKVFCRTLSSNEKVVSLHMNFGFETEGILRQHVRIN DGYEDITIQAINERAWAQNRPKIEKYLRVIVDVDKIGPITGRS" misc_feature 10045..10503 /locus_tag="ClothDRAFT_2448" /note="N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443" /db_xref="CDD:185998" gene 10623..10838 /locus_tag="ClothDRAFT_2449" CDS 10623..10838 /locus_tag="ClothDRAFT_2449" /inference="protein motif:PFAM:PF00550" /note="PFAM: phosphopantetheine-binding; KEGG: rak:A1C_05940 acyl carrier protein" /codon_start=1 /transl_table=11 /product="phosphopantetheine-binding" /protein_id="ZP_05430588.1" /db_xref="GI:256005630" /db_xref="InterPro:IPR006163" /translation="MEKLIELVAEVLNLDKESISLETSRENTSAWDSLNHIRLVAEVE ERFNIKIPFEKVPYIKKVGDFLEYIRE" misc_feature 10626..10835 /locus_tag="ClothDRAFT_2449" /note="Phosphopantetheine attachment site; Region: PP-binding; cl09936" /db_xref="CDD:186876" gene 10844..12490 /locus_tag="ClothDRAFT_2450" CDS 10844..12490 /locus_tag="ClothDRAFT_2450" /inference="protein motif:TFAM:TIGR01686" /note="TIGRFAM: FkbH like protein; HAD-superfamily phosphatase, subfamily IIIC; KEGG: dvl:Dvul_2594 FkbH like protein" /codon_start=1 /transl_table=11 /product="FkbH like protein" /protein_id="ZP_05430589.1" /db_xref="GI:256005631" /db_xref="InterPro:IPR010033" /db_xref="InterPro:IPR010037" /translation="MKLSLLSNVNLDSLISRLSKQYDVYKTEGYGTWIQEIINPDSGL YSFGPDMVFIVLDGEEMLRGQSESNEIIDVNINYIEEAVKNNPNITFFVSNIDLWTAK IESAKSGSKERRLEFLWEDSLFLLCEKYKNLYVFDIKSIVEDKGREQFYSKKLWYLGG IKYSMKAEKLLEQYINRCVASFKGKRKKCLVLDLDNTLWGGVVGEAGIEGIELSDYKE GARYKDFQRKLKEIKDLGIILAVVSKNNFDDAIKVIREHKHMVLKEEDFVALKINWDL KSQNIRDLSEELNIGLDSMVFIDDNPVERESVKRELPEVVVPDFPQDSSELVDFATEL YNNYFYTLDTTYEDTVKTEIYRQNMKRRDAQKSSASYEDFLRSLETRIEIRRINAENV QRAAQLTQKTNQFNLTTKRYSEQELLALINDQGFEGFVAYVSDKFGDNGMVSVVITRR KSDSEVELDTFLLSCRVMGRFIEDRIIGFIEDLYKKAGYKKFITYYRPTEKNAPVKDL FERLGYTLLDVDPEGNKKYVLDFERLSECSRKEFGELIAL" misc_feature 10913..12391 /locus_tag="ClothDRAFT_2450" /note="Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882" /db_xref="CDD:33671" misc_feature 11405..11779 /locus_tag="ClothDRAFT_2450" /note="Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391" /db_xref="CDD:187016" gene 12487..12897 /locus_tag="ClothDRAFT_2451" CDS 12487..12897 /locus_tag="ClothDRAFT_2451" /inference="protein motif:PFAM:PF00903" /note="PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: dvl:Dvul_2593 lactoylglutathione lyase" /codon_start=1 /transl_table=11 /product="Glyoxalase/bleomycin resistance protein/dioxygenase" /protein_id="ZP_05430590.1" /db_xref="GI:256005632" /db_xref="InterPro:IPR004360" /translation="MKIHHVGYAVKNMETSIEEFLKIGYKKRGETVADEARKVLIQFM ELGDYCIELVAPMDADSPVNSIITKSGNTPYHICYSVDNIDEAIKKLKTEGYILMESP SGAVAIDFCKVAFLYNRDVGIIELVEESTQCGAR" misc_feature 12493..12870 /locus_tag="ClothDRAFT_2451" /note="Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249" /db_xref="CDD:176672" misc_feature order(12493..12495,12502..12504,12508..12510,12529..12531, 12541..12546,12550..12552,12556..12564,12628..12633, 12637..12639,12697..12702,12706..12708,12712..12717, 12721..12723,12766..12768,12772..12774,12832..12834) /locus_tag="ClothDRAFT_2451" /note="dimer interface; other site" /db_xref="CDD:176672" misc_feature order(12499..12501,12607..12609,12640..12642,12673..12675, 12712..12714,12823..12825,12829..12831,12859..12861, 12865..12867) /locus_tag="ClothDRAFT_2451" /note="substrate binding site; other site" /db_xref="CDD:176672" misc_feature order(12499..12501,12640..12642,12712..12714,12859..12861) /locus_tag="ClothDRAFT_2451" /note="metal-binding site" /db_xref="CDD:176672" gene 12924..13616 /locus_tag="ClothDRAFT_2452" CDS 12924..13616 /locus_tag="ClothDRAFT_2452" /inference="similar to AA sequence:KEGG:Cla_1323" /note="KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, putative formyltransferase" /protein_id="ZP_05430591.1" /db_xref="GI:256005633" /db_xref="InterPro:IPR003006" /translation="MNIIIATTKSWNIKNAQKFKKENESKYNTTIITNKDELTFEKVK LINPEYILFPHWSWIIPKEIFENFTCVVFHMTDLPFGRGGSPLQNLIERGIKKTKISA IKVDGGIDTGDIFFKRDLDLYGTAEEIFMRASKIIFNDMIPELLTKRPVPQKQEGEAT VFQRRKPEQSEISPDFDLEKIYDYIRMLDGEGYPRAFIKYGKYRLEFSRASMKNGKII ADVEIIEGDENE" misc_feature <13026..13610 /locus_tag="ClothDRAFT_2452" /note="Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223" /db_xref="CDD:30572" misc_feature <13044..13286 /locus_tag="ClothDRAFT_2452" /note="Formyl transferase; Region: Formyl_trans_N; cl00395" /db_xref="CDD:185966" gene 13609..14292 /locus_tag="ClothDRAFT_2453" CDS 13609..14292 /locus_tag="ClothDRAFT_2453" /inference="protein motif:PFAM:PF02585" /note="PFAM: LmbE family protein; KEGG: pca:Pcar_1118 hypothetical protein" /codon_start=1 /transl_table=11 /product="LmbE family protein" /protein_id="ZP_05430592.1" /db_xref="GI:256005634" /db_xref="InterPro:IPR003737" /translation="MSNILVVAAHPDDELLGVGGTIRRHVNNGDVADCLILGEGMTSR AEKREDWDKNTLSELKSQTLKAAEILGFRNVYFSDFPDNRFDSVDLLDIIKEVDKYIQ RLKPQIIYTHHYGDLNIDHRRTFEAVITASRPVGEYPVKEIYCFETPSSTEWNFKYGG NVFKPNVFIGIDDTIDAKLKAMECYKSEIRDYPHPRSIKALEIIAARWGTVVGKKYAE AFELIRKVV" misc_feature 13618..14271 /locus_tag="ClothDRAFT_2453" /note="GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929" /db_xref="CDD:163934" gene 14302..15366 /locus_tag="ClothDRAFT_2454" CDS 14302..15366 /locus_tag="ClothDRAFT_2454" /inference="protein motif:PFAM:PF04101" /note="PFAM: Glycosyltransferase 28 domain; KEGG: har:HEAR1124 putative polysaccharide biosynthesis protein" /codon_start=1 /transl_table=11 /product="Glycosyltransferase 28 domain protein" /protein_id="ZP_05430593.1" /db_xref="GI:256005635" /db_xref="InterPro:IPR007235" /translation="MLNIGIRVDGSANIGMGHIMRCLSLAKGFRNAGANVYFLSRFEQ GISRIRQDNFEVLEMPYRKSRNSGGFFYGDASELEEDAEEIICRIRAFNLDVLIIDSY NVSREFFLKLKPHVRKLCYIDDLNKFVYPVDVLINGNITAPALNYAKYSDDELMLLGL KYNLIRDEFKNLPERIINRDVREIMITTGGSDPFNLTLRLANAILPEEEFKDVRINIV VGSGFTNADKLRELSERNPNVVLHENVLRMSEVMLKSDVAISAGGSTLYELCACGTPA LAVVIADNQREMVDMLSSEGYIISLGWHEELDDRELLRKVKSLCGDYEKRVLFSRKMQ KLVDGEGVKRVVEEIMKITS" misc_feature 14311..15156 /locus_tag="ClothDRAFT_2454" /note="pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590" /db_xref="CDD:163339" misc_feature <14788..15345 /locus_tag="ClothDRAFT_2454" /note="Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013" /db_xref="CDD:186885" gene 15425..16594 /locus_tag="ClothDRAFT_2455" CDS 15425..16594 /locus_tag="ClothDRAFT_2455" /EC_number="2.6.1.50" /inference="protein motif:PRIAM:2.6.1.50" /note="PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: abc:ACICU_00076 pyridoxal phosphate-dependent enzyme" /codon_start=1 /transl_table=11 /product="Glutamine--scyllo-inositol transaminase" /protein_id="ZP_05430594.1" /db_xref="GI:256005636" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR001597" /translation="MEKSAEQKFIPYGCQWIEEDDINAVVEVLRGDYLTTGPKVKEFE ENLARYTGAKYAVAVSNGTAALHAACFAAGIKEGDEVITTPITFAASANCLLYMGAKP VFADIDPDTYNIDPKEIRARITEKTKAIIPVHFTGQPCDMDEILKIAEEYNLLVIEDG AHALGAEYKGRKIGSLGDMTTFSFHPVKHITTGEGGAIVTNSEELYKKLTLFRTHGIT RETGDLLENHGPWYYEQQYLGYNYRMTDIQAALGISQLKKSDKFLQLRRDYAKLYTEA FKSVDEVVVPYQLDGTDSSWHLYILKLKTERLNCDRKKIFEELKERRIGVNVHYIPVY YHPFYRKLGYKKGLCPNAEDFYERIITLPLFPKMEKEDILYVISNVKDVIQKHII" misc_feature 15437..16585 /locus_tag="ClothDRAFT_2455" /note="Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399" /db_xref="CDD:30748" misc_feature 15485..16567 /locus_tag="ClothDRAFT_2455" /note="3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616" /db_xref="CDD:99740" misc_feature order(15608..15613,15899..15901,15908..15910,15971..15973, 15983..15988,16409..16411) /locus_tag="ClothDRAFT_2455" /note="inhibitor-cofactor binding pocket; inhibition site" /db_xref="CDD:99740" misc_feature order(15608..15613,15683..15685,15899..15901,15908..15910, 15971..15973,15986..15988) /locus_tag="ClothDRAFT_2455" /note="pyridoxal 5'-phosphate binding site; other site" /db_xref="CDD:99740" misc_feature 15986..15988 /locus_tag="ClothDRAFT_2455" /note="catalytic residue; other site" /db_xref="CDD:99740" gene 16610..17554 /locus_tag="ClothDRAFT_2456" CDS 16610..17554 /locus_tag="ClothDRAFT_2456" /inference="protein motif:PFAM:PF01370" /note="PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; KEGG: mxa:MXAN_3507 UDP-glucose 4-epimerase" /codon_start=1 /transl_table=11 /product="NAD-dependent epimerase/dehydratase" /protein_id="ZP_05430595.1" /db_xref="GI:256005637" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR002225" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR013120" /translation="MNILVTGGAGFIGRWVVKRLLEDGHKVWVLDDLSNGQRKNIEEF LSNPNFAGFVEGDIKNIPVLETLFENKFDICYHLAASINVQDSIDDPGTTFQNDVVGT FNVLEQCRKHNTKIVFMSTCMVYDRANDENGITEAHPTKPASPYAGSKIAGENMVLSY WYAYKLPAVVIRPFNTYGPMQKSSGEGGVVAIFIRRNLEGLPLNIYGDGCQTRDLLYV EDCAEFVVRAGYSDRVNGEIINAGLGRDISINDLALLIAKDKEKIVHVPHIHPQSEIA KLLCNYQKAKELLGWTPKVSLEEGIKRTEEWIRSTLAT" misc_feature 16610..17548 /locus_tag="ClothDRAFT_2456" /note="Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451" /db_xref="CDD:30800" misc_feature 16622..>17128 /locus_tag="ClothDRAFT_2456" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" gene 17618..18013 /locus_tag="ClothDRAFT_2457" CDS 17618..18013 /locus_tag="ClothDRAFT_2457" /inference="protein motif:PFAM:PF03646" /note="PFAM: flagellar protein FlaG protein; KEGG: nam:NAMH_0486 polar flagellin" /codon_start=1 /transl_table=11 /product="flagellar protein FlaG protein" /protein_id="ZP_05430596.1" /db_xref="GI:256005638" /db_xref="InterPro:IPR005186" /translation="MKIESMDAANLQVLKTQCKDYQPNTVNSSNNFGKEASNEKKTHV DVSVSGNESEAGLSQRVIIKAIEKANKAINGIHTELEFSIHEKSKEIMVKVIDSETKE VIREIPPEKILDMVAAMLEMAGIIVDERG" misc_feature <17846..18007 /locus_tag="ClothDRAFT_2457" /note="FlaG protein; Region: FlaG; cl00591" /db_xref="CDD:186094" gene 18019..20535 /locus_tag="ClothDRAFT_2458" CDS 18019..20535 /locus_tag="ClothDRAFT_2458" /inference="protein motif:PFAM:PF07195" /note="PFAM: flagellar hook-associated 2 domain protein; flagellar hook-associated protein 2 domain protein; KEGG: sat:SYN_02805 flagellar hook and flagellar capping protein" /codon_start=1 /transl_table=11 /product="flagellar hook-associated 2 domain protein" /protein_id="ZP_05430597.1" /db_xref="GI:256005639" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /translation="MAVNNISNLINSRIRLTGISSGLDTDAIIEQLMSVERAKVDKIK QEKQILEWKRDIYRDIINKLRSITDEYFNVLKPKTNFTSQSAFTSFKISSSNESVVTV TANASAASKVHSITVHSLASAAKIVGTSGLVDGIKGSNAVNTLSLQGKEINVTLDGVT KTIALEDYTSLSDLETKLESALAKAFGTGKIDVVTTGGSIEFKCLLNGSTLSISDTAN NYISSLGFSNGQKNFITGNSDVNSDFSLYTDGSFKITVGNGTAQTINISDATSIDDLV AKIQQAIDSNSELSGKVHVSNDGSKLTFISVSGETVKLTSGDSNNVLDKLGFSDGATI TATSSTVIDLSGNEKGKTFIININGVDKIIEIDKDYNDLDELASYIQNQLGGTVNVTK DASGSRLVFSTGGADRLIFKKGPEDGLEKLGFTANDNRSNRISLTTKLDSLSTIFKND LNIADPDANVVFTINGQTIDVGKTYANATLSDVMNAINSSSAGVKITYDSLNDRFIME SKTMGATSEIELTDTDPANGLLKAMGLIGGTYTAGTDAEFDLDGVTGMKRSTNEFTIE GVTYSLKGVSSEPVKIDVKADIDAVVENIKNFVNSYNEMLAKINSVLTEERYRDYLPL TDDQKKAMSEDDIKLWEQKAKSGLLRSDSILENIVTNLRRALYDKVEGCSLSLYQIGI TTGSYQDKGKLVIDEEKLRAALTDNYDAVVQLFTQGSQYTYSEALNDPNKRAVRYKEA GIAQRIYDILQDNIRITRNANGKKGILLEKAGIAGDLTEYDNLIVNEIKAKETLIDEM LVKIYKKEEYYYSKFAAMEKMLDAMNSQSMWLTQQFSNYY" misc_feature 18067..>18897 /locus_tag="ClothDRAFT_2458" /note="flagellar capping protein; Validated; Region: fliD; PRK07737" /db_xref="CDD:181097" misc_feature 18076..18393 /locus_tag="ClothDRAFT_2458" /note="Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465" /db_xref="CDD:145547" misc_feature <18637..19203 /locus_tag="ClothDRAFT_2458" /note="Bacterial membrane protein YfhO; Region: YfhO; pfam09586" /db_xref="CDD:150299" misc_feature <19378..>19707 /locus_tag="ClothDRAFT_2458" /note="Protein of unknown function (DUF3383); Region: DUF3383; pfam11863" /db_xref="CDD:152299" misc_feature 19645..20493 /locus_tag="ClothDRAFT_2458" /note="Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195" /db_xref="CDD:115824" gene 20600..21004 /locus_tag="ClothDRAFT_2459" CDS 20600..21004 /locus_tag="ClothDRAFT_2459" /inference="protein motif:TFAM:TIGR00208" /note="TIGRFAM: flagellar protein FliS; PFAM: flagellar protein FliS; KEGG: pca:Pcar_1111 flagellar protein FliS" /codon_start=1 /transl_table=11 /product="flagellar protein FliS" /protein_id="ZP_05430598.1" /db_xref="GI:256005640" /db_xref="InterPro:IPR003713" /translation="MALKNAYDQYKENSVYTASPEELTLMLYNGLVKFLMQAQMALND KNIEKANKSIIRAQDIISEFRCTLDMKYDIAHQLDLLYDYMYRRLVDANIKKDGAIVE EVLGFAKELRDTWEQAMKIAKQQNSRTAQVAK" misc_feature 20600..20974 /locus_tag="ClothDRAFT_2459" /note="Flagellar protein FliS; Region: FliS; cl00654" /db_xref="CDD:186129" gene 21015..21503 /locus_tag="ClothDRAFT_2460" CDS 21015..21503 /locus_tag="ClothDRAFT_2460" /inference="protein motif:PFAM:PF05130" /note="PFAM: FlgN family protein; KEGG: cju:C8J_1219 peptidase, M23/M37 family" /codon_start=1 /transl_table=11 /product="FlgN family protein" /protein_id="ZP_05430599.1" /db_xref="GI:256005641" /db_xref="InterPro:IPR007809" /translation="MNGTPEGYIQRLVEISKKKMDCLKSILSLTRAQTEAISEEGMDG LQSLIDQKQSKIDEINGLDEEFNACFTALKQKLGVKSLDEAGTLGIKGVKELQSLVSK IMGLLKEISEVERSNKEKANSLLSFLGAKIREIREGRKVSSAYSPAASLSPPSYFIDQ KK" misc_feature 21045..21434 /locus_tag="ClothDRAFT_2460" /note="FlgN protein; Region: FlgN; cl09176" /db_xref="CDD:186847" gene 21734..21928 /locus_tag="ClothDRAFT_2461" CDS 21734..21928 /locus_tag="ClothDRAFT_2461" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430600.1" /db_xref="GI:256005642" /translation="MQLVLQPKLYSAKAQRGKDIIRLYFNGLYNFHSYGSFLFGYIAE NIKNSILCLYRGVKGMIYDD" gene 21921..22868 /locus_tag="ClothDRAFT_2462" CDS 21921..22868 /locus_tag="ClothDRAFT_2462" /inference="protein motif:PFAM:PF01544" /note="PFAM: Mg2 transporter protein CorA family protein; KEGG: dvl:Dvul_0663 Mg2+ transporter protein, CorA family protein" /codon_start=1 /transl_table=11 /product="Mg2 transporter protein CorA family protein" /protein_id="ZP_05430601.1" /db_xref="GI:256005643" /db_xref="InterPro:IPR002523" /translation="MIEIYKSYDTDLFPVKIDSFEKGCWINIVSPTEQELNFVETSLN VSSNFLRDPLDEEEKPRIDVEDNQTLVIVDVPYVYEEDRDIKYETIPLGIIILEDYFI TICSKETFLIQYFKDKKVKDYFTFKKTRFTLQILYLIAKDFLKYLRHIDKKSYEAETS LHKSLQNKELFKLLELEKSLVFFTTSLKSNEIVMEKLLKGKYIKLYEEDQDLLEDVII ENKQAIEMANIYSSILSGTMDTFASIISNNLNVVMKVLTSITIIMAIPTMIASFFGMN VQMPFGLDTNNPYAFWGILGISAVISVAAGIFLYKKDMF" misc_feature 21921..22865 /locus_tag="ClothDRAFT_2462" /note="Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598" /db_xref="CDD:30943" misc_feature 21990..22853 /locus_tag="ClothDRAFT_2462" /note="CorA-like Mg2+ transporter protein; Region: CorA; cl00459" /db_xref="CDD:186010" gene complement(22865..23806) /locus_tag="ClothDRAFT_2463" CDS complement(22865..23806) /locus_tag="ClothDRAFT_2463" /inference="protein motif:COG:COG1506" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="Dipeptidyl aminopeptidase/acylaminoacyl-peptidase-like protein" /protein_id="ZP_05430602.1" /db_xref="GI:256005644" /translation="MRITVLTYSRQKSHIIRKIILFIVLLALIFSVVVSAVSVIAGWK LIHPKRLNILDFSANIVPSYTDVSFKDINDEFELKGWYFNVTGSSKTVILAHGYGKNR LNFGENTIHLIKSLLDKGYNVLAFDFRNSGESEGNKTTFGVCEKNDLLGAIQYVKNKG SEKIVLMGFSTGASACILAAAESDDVDAVIAESPYSDLNTYFEQNVNNLTNFPAIPFN KTITFATFFLADIKPDEASPVKAVQAVSPRPVLLIHSKDDTKVPVENSRLIYKASNPY TTTFWETSGADHEEIYQANPEEYVKKVTDFLEKLSQT" sig_peptide complement(23696..23806) /locus_tag="ClothDRAFT_2463" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.808 at residue 37" misc_feature complement(22877..23575) /locus_tag="ClothDRAFT_2463" /note="Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596" /db_xref="CDD:30941" misc_feature complement(22880..23476) /locus_tag="ClothDRAFT_2463" /note="Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031" /db_xref="CDD:187168" gene 24175..24792 /locus_tag="ClothDRAFT_2464" CDS 24175..24792 /locus_tag="ClothDRAFT_2464" /inference="protein motif:COG:COG4843" /note="KEGG: pca:Pcar_2434 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430603.1" /db_xref="GI:256005645" /translation="MEGIVNSGLFNWLILPLLIFFSRIIDVTIGTIRIIFVSRGKKYL APVLGFFEVLVWIMAISQIMQNLNNFVCYFAYAAGFATGTFVGIIIEEKLAIGTLVIR VIVDKNECELKERLSKSGFGVTVVDAKGKNGDVKIIYTIIKRKELQEVVRIIEECNSK AFYSIEDARKVNQGIFRTGTSNHDGTRFFNLFRIHRMSGLDKKTR" misc_feature 24193..24714 /locus_tag="ClothDRAFT_2464" /note="hypothetical protein; Provisional; Region: PRK04164" /db_xref="CDD:179759" misc_feature 24205..24711 /locus_tag="ClothDRAFT_2464" /note="Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498" /db_xref="CDD:158885" gene 24840..25748 /locus_tag="ClothDRAFT_2465" CDS 24840..25748 /locus_tag="ClothDRAFT_2465" /inference="protein motif:PFAM:PF00165" /note="PFAM: helix-turn-helix- domain containing protein AraC type; Cupin 2 conserved barrel domain protein; SMART: helix-turn-helix- domain containing protein AraC type; KEGG: dal:Dalk_4095 transcriptional regulator, AraC family" /codon_start=1 /transl_table=11 /product="transcriptional regulator, AraC family" /protein_id="ZP_05430604.1" /db_xref="GI:256005646" /db_xref="InterPro:IPR000005" /db_xref="InterPro:IPR013096" /translation="MDNSNNNILPKAWESFLSSSTFIPVIVKTIERFHDTSWHMEPNK HECFEMVYIKRGKAVFEIAGYPAEIGPNDIIIIKPNQPHKFIVKSESGCEFIVLSFKF VNRFDGQYSDVSLENFLDFVSGKETGPFITLKVSQKNDIIVLLNRILKERENPDIGSE FLNYLLVMELFVLISRALKMEWENSIKNKSPKIKELIQASVNYINNNYERDISLKDIA RYVFLSTSYFTRAFKEEMGISPINYLLKIRVERAKELLKDTDNRISDIALSVGFSNQQ RFNDIFKKYVKLTPLQYRKNVQVKKH" misc_feature 24933..>25139 /locus_tag="ClothDRAFT_2465" /note="Cupin domain; Region: Cupin_2; cl09118" /db_xref="CDD:186830" misc_feature 25449..25574 /locus_tag="ClothDRAFT_2465" /note="Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165" /db_xref="CDD:143933" misc_feature 25470..25721 /locus_tag="ClothDRAFT_2465" /note="helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342" /db_xref="CDD:128636" misc_feature 25614..25724 /locus_tag="ClothDRAFT_2465" /note="Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165" /db_xref="CDD:143933" gene 25877..27136 /locus_tag="ClothDRAFT_2466" CDS 25877..27136 /locus_tag="ClothDRAFT_2466" /inference="protein motif:TFAM:TIGR02083" /note="TIGRFAM: 3-isopropylmalate dehydratase, large subunit; homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; KEGG: sat:SYN_00091 3-isopropylmalate dehydratase large subunit" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase, large subunit" /protein_id="ZP_05430605.1" /db_xref="GI:256005647" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006251" /db_xref="InterPro:IPR011823" /db_xref="InterPro:IPR011826" /translation="MGMTMTQKILADHAGLDKVSPGQLIKAKLDMVLGNDITTPVAVK EFRKIGVNKVFDVNKIAIVPDHFTPNKDIKSAEQVKFIREFAREMGIVNFFEVGQMGV EHALLPEKGLVVPGDVVIGADSHTCTYGALGAFSTGIGSTDMAAGMATGEAWFKVPEA MKFVLKGKPGKWVSGKDIILHIIGMIGVDGALYRSMEFTGDGVAHLSMDDRFAMANMA IEAGAKNGIFEVDEKTIEYVKEHSTRQYKVYKADEDAEYVATYEIDLSQVKPTVAFPH LPSNTRTIDNVGNIKIDQVVIGSCTNGRIEDLRVAAEVLKGRKVHKDVRCIIIPATQK IWKQAMNEGLFDIFIDAGAAVSTPTCGPCLGGHMGILAKGERAVATTNRNFVGRMGHP ESEIYLASPAVAAASAVLGRIGSPDEL" misc_feature 25877..27133 /locus_tag="ClothDRAFT_2466" /note="3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402" /db_xref="CDD:179006" misc_feature 25967..27115 /locus_tag="ClothDRAFT_2466" /note="3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583" /db_xref="CDD:153133" misc_feature order(25979..25981,25988..25990,26243..26248,26966..26968, 27023..27025,27038..27040) /locus_tag="ClothDRAFT_2466" /note="substrate binding site; other site" /db_xref="CDD:153133" misc_feature order(26249..26251,26774..26776,26954..26956,26963..26968, 27020..27022) /locus_tag="ClothDRAFT_2466" /note="ligand binding site; other site" /db_xref="CDD:153133" gene 27126..27695 /locus_tag="ClothDRAFT_2467" CDS 27126..27695 /locus_tag="ClothDRAFT_2467" /inference="protein motif:TFAM:TIGR02087" /note="TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: hhe:HH1135 3-isopropylmalate dehydratase" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase, small subunit" /protein_id="ZP_05430606.1" /db_xref="GI:256005648" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR011824" /db_xref="InterPro:IPR011827" /translation="MNFNLKSYMQRVEYVEVKERGKMKAQGKAIKYGDNVDTDVIIPA RYLNTSDPNELAKHCMEDIDTEFVSKVQKGDIMVAGKNFGCGSSREHAPIAIKASGIS CVIAETFARIFYRNAINIGLPIIECPEAAKDISDGDIVSIDFDTGKIVNVTKNKEYTG VPFPEFMQEIIASDGLIGYIKKQIGNKEA" misc_feature 27216..27557 /locus_tag="ClothDRAFT_2467" /note="Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3...; Region: IPMI_Swivel; cd01577" /db_xref="CDD:73275" misc_feature 27384..27392 /locus_tag="ClothDRAFT_2467" /note="substrate binding site; other site" /db_xref="CDD:73275" gene 27697..28785 /locus_tag="ClothDRAFT_2468" CDS 27697..28785 /locus_tag="ClothDRAFT_2468" /EC_number="1.1.1.85" /inference="protein motif:TFAM:TIGR00169" /note="KEGG: dvl:Dvul_0387 3-isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="ZP_05430607.1" /db_xref="GI:256005649" /db_xref="InterPro:IPR001804" /db_xref="InterPro:IPR004429" /translation="MGKYKIAVLPGDGIGPEVIEQAVKVIEAVGEIYNHSFELKEGLL GGCAIDATGEPFPKETLELCKSSDAVLLGAVGGPKWDNLPGDKRPEAGLLGIRGALGL YANLRPAVIYQALKGASPLRSDIVKDGIDIMVVRELTGGMYFGERGRVQTENMGQAAF DTEKYSEFEVERIARLAFETAMKRNKKLTSVDKANVLESSRLWREVVNRVASDYPEVE LNHMYVDNAAMQLVRNPAQFDVIVTSNMFGDILSDEASMITGSIGMLPSASLGEGSLG LYEPIHGSAPDIAGQDKANPIATILSVAMMMKYSFGLEDAFRAIENAVVNVLGMGYRT ADIASPDTPRENIVGTKEMGRLIISKLK" misc_feature 27703..28782 /locus_tag="ClothDRAFT_2468" /note="Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445" /db_xref="CDD:185999" misc_feature 27727..28782 /locus_tag="ClothDRAFT_2468" /note="isocitrate dehydrogenase; Validated; Region: PRK06451" /db_xref="CDD:180566" gene complement(28904..29539) /locus_tag="ClothDRAFT_2469" CDS complement(28904..29539) /locus_tag="ClothDRAFT_2469" /inference="protein motif:TFAM:TIGR00498" /note="TIGRFAM: LexA repressor; PFAM: LexA DNA-binding domain protein; KEGG: hdu:HD0545 LexA repressor" /codon_start=1 /transl_table=11 /product="transcriptional repressor, LexA family" /protein_id="ZP_05430608.1" /db_xref="GI:256005650" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /translation="MSSDFDFLTAKQKKVYMVIESFIKSKGIPPTVREIGELVGEKTP GAVQGILNRLEQKGVIKREVGMARSIQLVNTNSQYAPHVYLPKIKKVSQRNVNDLLNI YNIINYLPVPSSLFPEGSDCFIIDCPDNSLSESGIKYEDVLVISRNYELKDGDIVMIL YENHVLLRYYTHHDNPDLVILKADSDLLGKEVFNRNEVTIIGKLVGKYTKY" misc_feature complement(28907..29518) /locus_tag="ClothDRAFT_2469" /note="LexA repressor; Validated; Region: PRK00215" /db_xref="CDD:178931" misc_feature complement(29336..29518) /locus_tag="ClothDRAFT_2469" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:185792" misc_feature complement(28925..>29119) /locus_tag="ClothDRAFT_2469" /note="Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529" /db_xref="CDD:119397" misc_feature complement(29036..29038) /locus_tag="ClothDRAFT_2469" /note="Catalytic site; other site" /db_xref="CDD:119397" gene 29888..31063 /locus_tag="ClothDRAFT_2470" CDS 29888..31063 /locus_tag="ClothDRAFT_2470" /inference="protein motif:TFAM:TIGR01975" /note="TIGRFAM: isoaspartyl dipeptidase; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: see:SNSL254_A4867 beta-aspartyl peptidase" /codon_start=1 /transl_table=11 /product="isoaspartyl dipeptidase" /protein_id="ZP_05430609.1" /db_xref="GI:256005651" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR010229" /db_xref="InterPro:IPR013108" /translation="MEKKIFKLLKNGTCYIPEFIGKKDILVVQNKIYKIENHIDESVV PDLEIIDCSGKIVCPGLIDQHIHITGGGGEEGPGSRIPEIMLSECLTAGITTAVGVLG ADSITRNISGLLAKARALEEEGLNTYIYTGSYRIPTATLTGSVMSDIALIDKIIGVGE IAVSDHRSSHPSLDMLKAVASEARMGGLVGKKAGVVHIHVGDGKKGLEPVIELVANSD FPIEMFVPTHLNRNRTLFFQAIEYAKMGGNIDLTAGETNETGYAVPDALKLLADAGVD MDRVTVSSDANGSIPAKEGCGPGVGRADELINDIRSSILSGKLTVEQALKTVTVNVAK VLKLYPKKGVIRPGSDADILVFGKEDLKLDKVFVNGEQFVNNGKVQKWGRYEEKWHG" misc_feature 29903..31045 /locus_tag="ClothDRAFT_2470" /note="isoaspartyl dipeptidase; Provisional; Region: PRK10657" /db_xref="CDD:182623" misc_feature 29903..31045 /locus_tag="ClothDRAFT_2470" /note="Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281" /db_xref="CDD:185881" misc_feature order(30080..30082,30086..30088,30482..30484,30569..30571, 30740..30742) /locus_tag="ClothDRAFT_2470" /note="active site" /db_xref="CDD:30035" gene 31092..31388 /locus_tag="ClothDRAFT_2471" CDS 31092..31388 /locus_tag="ClothDRAFT_2471" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430610.1" /db_xref="GI:256005652" /translation="MIKRANTNLGDVMERINFQKTGTRSNIILLTVGWISALLSLVIY PFIFGVVGVITGILATKNGSKAGLPLIVSSIILMGIGLIFSGVIMNYARRYLGI" gene 31494..32315 /locus_tag="ClothDRAFT_2472" CDS 31494..32315 /locus_tag="ClothDRAFT_2472" /EC_number="3.4.15.6" /inference="protein motif:TFAM:TIGR02069" /note="KEGG: csa:Csal_1113 cyanophycinase; TIGRFAM: cyanophycinase; PFAM: peptidase S51 dipeptidase E" /codon_start=1 /transl_table=11 /product="cyanophycinase" /protein_id="ZP_05430611.1" /db_xref="GI:256005653" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR011811" /translation="MGQKVRGNLIIIGGAEDKVGKKTILKYVADIVREKKGSLVILTT ATQKPQEVGNNYRQVFETLGLMDIDVLNINSRDEADLDENAERIRSSGGIFFTGGDQL RITSILGGTKVYKALHEVYSKGVVIVGTSAGASVMSNTMIVEGKDNEPARKCTMKMAP GLGFLEEAIIDQHFDQRGRIGRLLCGVAENPFMLGIGIDEDTAIRVYPDAHFEVLGSN AVTVIDGSTIKSTNVSELNPDEILAISGVTLHVLPCGYGFDMKKREVIQPTDRKL" misc_feature 31515..32165 /locus_tag="ClothDRAFT_2472" /note="Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145" /db_xref="CDD:153239" misc_feature order(31884..31886,32010..32012,32091..32093) /locus_tag="ClothDRAFT_2472" /note="proposed catalytic triad; other site" /db_xref="CDD:153239" misc_feature 31884..31886 /locus_tag="ClothDRAFT_2472" /note="active site nucleophile" /db_xref="CDD:153239" gene 32343..32549 /locus_tag="ClothDRAFT_2473" CDS 32343..32549 /locus_tag="ClothDRAFT_2473" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: vei:Veis_4990 cyanophycin synthetase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430612.1" /db_xref="GI:256005654" /translation="MRIQSIQCFAGRNIYSHKPVVKVTLDIGELYKLPTKDLGDFNER LLALFPGLKNIIVLWDMRADLKNV" misc_feature 32343..>32504 /locus_tag="ClothDRAFT_2473" /note="cyanophycin synthetase; Provisional; Region: PRK14016" /db_xref="CDD:184454" gene 32516..34990 /locus_tag="ClothDRAFT_2474" CDS 32516..34990 /locus_tag="ClothDRAFT_2474" /inference="protein motif:TFAM:TIGR02068" /note="TIGRFAM: cyanophycin synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; RimK domain protein ATP-grasp; phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; KEGG: ftn:FTN_1112 cyanophycin synthetase" /codon_start=1 /transl_table=11 /product="cyanophycin synthetase" /protein_id="ZP_05430613.1" /db_xref="GI:256005655" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011810" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR013651" /translation="MGYEGGFEERLKEGTYIGHVTEHLIIELQNILGYEVNYGKTRIV EEPSLYFIVFEYKNEKCAIECARAAVNIVLKLVRNEEVDTEAIINNLRAIAVETDMGP STKAIYEEAKKRGIPVTRIGDGSVLRLGYGKYSRIVQASLTDFPSCINVDMAGNKQLA KRLLAENKIPVPDGDTAYSFEGALQIAREIGFPVVIKPVDSNQGKGVTLNIKDEQEME IAYNEARKYSRVVLVEKYVKGKDYRVLVVGDRVAAVAERRPPFVIGDGVHTVEELVAI ENLSSLRGDDHEKPLTKIKLDATALKVLKDQGIGKDHVPSLGERIYLRYNGNLSTGGT ARECTDEIHPYNADIAVKAAQIIGLDIAGVDITTEDISVPISENGGAIIEINAAPGLR MHLFPSEGKTRNVAADILDMLFPEASPHSIPIVSVTGTNGKTTTTRLIGHTLACLGKK VGMTSTGGIFIGDECVLKGDNTGPTSAAMVLSSKEVEVAVLETARGGIVRKGLGYDLA DVGVITNIAEDHLGIDGMNTLEDLAFAKSLVVEAVKPGGYSVLNADDKFVRYFMERAK GEIILFSKNNSNPVVKEHMQKGGKALYVDKDTIFIYNGKTAEVLMSVKEIPITYGGMI ECNIENSLAAASALYGLNLSIEAIRKGLATFNPDMESNPGRFNIVDMGDFKVMLDYGH NPAGYLEVMKFLDKIDAKRLVGVIGMPGDRDDLSIYKAGEICSKCFSKIYIKEDSDLR GREPGEVAGILYDAVISSGTKKENVEIIYSEDRALEKALLDAQPGDFVVMFYENFERA AEVVERVRRELLENTDTAGPVIQNVG" misc_feature 32519..34519 /locus_tag="ClothDRAFT_2474" /note="cyanophycin synthetase; Provisional; Region: PRK14016" /db_xref="CDD:184454" misc_feature 32975..33694 /locus_tag="ClothDRAFT_2474" /note="Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087" /db_xref="CDD:164032" misc_feature 33827..34429 /locus_tag="ClothDRAFT_2474" /note="Mur ligase middle domain; Region: Mur_ligase_M; pfam08245" /db_xref="CDD:149357" misc_feature 34502..34759 /locus_tag="ClothDRAFT_2474" /note="Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875" /db_xref="CDD:145824" gene 35156..35719 /locus_tag="ClothDRAFT_2475" CDS 35156..35719 /locus_tag="ClothDRAFT_2475" /EC_number="3.5.4.16" /inference="protein motif:TFAM:TIGR00063" /note="KEGG: mno:Mnod_7919 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="ZP_05430614.1" /db_xref="GI:256005656" /db_xref="InterPro:IPR001474" /translation="MIDKERIKAAVRELLIGIGEDPDREGLLETPDRVARMCEEIFAG LHQDPKSVVKVFQEENHEEMVMVKDIPIYSICEHHLLPFIGVAHVVYIPRKGKIMGLS KLARIVDIIARKPQLQERLGSEVANVIMESINPLGVAVVVEAEHLCMTMRGIKKAGSK TVTSALRGIIKTDARTRAEVMALINGR" misc_feature 35162..35710 /locus_tag="ClothDRAFT_2475" /note="GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642" /db_xref="CDD:29763" misc_feature order(35162..35164,35171..35176,35183..35185,35195..35197, 35204..35209,35213..35215,35219..35221,35225..35227, 35231..35239,35243..35248,35252..35254,35264..35266, 35273..35275,35288..35290,35315..35317,35321..35323, 35336..35347,35351..35362,35366..35368,35372..35374, 35384..35389,35396..35401,35405..35407,35411..35413, 35432..35437,35444..35446,35456..35464,35471..35473, 35501..35509,35513..35515,35522..35524,35552..35554, 35591..35599,35606..35611,35624..35629,35633..35641, 35645..35653,35666..35671,35678..35680,35684..35692) /locus_tag="ClothDRAFT_2475" /note="homodecamer interface; other site" /db_xref="CDD:29763" misc_feature 35174..35713 /locus_tag="ClothDRAFT_2475" /note="GTP cyclohydrolase I; Provisional; Region: PLN03044" /db_xref="CDD:178607" misc_feature order(35252..35254,35261..35263,35381..35383,35387..35392, 35450..35452,35456..35461,35471..35473,35504..35512, 35591..35593,35597..35599,35609..35611) /locus_tag="ClothDRAFT_2475" /note="active site" /db_xref="CDD:29763" misc_feature order(35381..35383,35387..35392,35591..35593,35597..35599) /locus_tag="ClothDRAFT_2475" /note="putative catalytic site residues; other site" /db_xref="CDD:29763" misc_feature order(35381..35383,35387..35392,35597..35599) /locus_tag="ClothDRAFT_2475" /note="zinc binding site; other site" /db_xref="CDD:29763" misc_feature order(35534..35536,35543..35545,35561..35563,35567..35569, 35654..35662,35666..35680) /locus_tag="ClothDRAFT_2475" /note="GTP-CH-I/GFRP interaction surface; other site" /db_xref="CDD:29763" gene 35797..36534 /locus_tag="ClothDRAFT_2476" CDS 35797..36534 /locus_tag="ClothDRAFT_2476" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430615.1" /db_xref="GI:256005657" /translation="MWFFIIMGVFLIVMGLTIHVFKWYFLISGYNTMPEEKKANVDVK GLGRLIGIYFYVNGAVSIAAGVFYALEPGKILISVIAFFMLSTFYVVIRAQKYDGNLY DENGKLRKGAWKQLVIPGAICVVTLIFVAVVMYFSYQPTRVSFLEEGIQIHGMYGEVY TWESIENVSLKEELPTIQIRTNGSALGSKLKGHFKTKELGSVKLFVNTENPPFIYLET NNGIVIFNMNDRDETQKIFNEILRKVE" gene 36940..37530 /locus_tag="ClothDRAFT_2477" CDS 36940..37530 /locus_tag="ClothDRAFT_2477" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430616.1" /db_xref="GI:256005658" /translation="MIPLFLCFLYMFYGYTVMKNELDNYMFIRTSGFVMMFMTILSMC FGVINARQEKDAKFEEVLNTLPAAWTRQITKVFTWSVWSFVYCLILAVFCTVWVDNGL NELGKYALQVVPYIFVNFYMPMVSTWLIAYSVEKTFNPKIGWPVLLLIWYLISPINDS RSKVALMLNQFVEDPYGDSRLLHYGLDTTLQAPSQY" ORIGIN 1 atttaaatgc agggcagaca tgcatagctc cggattacgt ttttgtaaaa aaagagcttt 61 taggggattt tgtaagccac ttaaaacatt acataaaaaa atattattat tctgacggca 121 gcggaagatg cagcaactac tgcggtatta tcaacgaacg tcactttaac aggctgaaaa 181 atgtgtttga ggtgacggta aaagaggggg caaaagtttg tgagggcggt ctgtttgttg 241 agaatgaatg ctatatatca cctactgttt tgacggatgt gggcagagac tcatatataa 301 tggaggagga aattttcggg ccgattttgc cggtgctgac ttatgaaaaa atcgatgatg 361 tcattgagta tataaactca aagcctgctc ctttggtgtt gtatgttttc agcagggaca 421 ggaaatttta cagacatgtg attaataacg taatttccgg ggattgtctg ataaatgatg 481 tgatagcgca ctttgccaat cccaggctgc cttttggagg gcacaacgcc agtggaatcg 541 gaaagtccca tggttattac ggatttagag aattttccca cctgcgttca atcatgattc 601 aaccaaaacg cacaatgttg cagttgctct accctccgta cggcgagttt gtaaaaaagt 661 tgattgagtg gagtacgaaa tatttttagt acaattcttc ttacagtgca aatcataaat 721 ttttccataa aaaaaagata aattcattaa agtatcgttt gattttaccc gataaatatg 781 atgtacaggg ataatggcaa tttatctatt agcggcgccg aatagataaa aggccatatc 841 cttgcaccaa aatcaaaata cgcgatggaa aggattccaa agcgaaaatc aaggaggaat 901 gaattatgag aattaacaac aacattatgg cgtacaacgc ccacagacaa ttaaaagtaa 961 atgcgtcagc gcaggaaaaa tccttggaga aattgtcatc aggctacaga atcaacaggg 1021 ccggtgacga tgcagcaggt ctgtccatat ccgaaaaaat gagagcgcag atcagaggtc 1081 tgcagatggc gtcaaagaat gcccaggacg gtatttcatt gatccagact gcagaaggag 1141 ctttaactga aactcacgca atccttcaaa gaatgagaga gcttgcagta caggcagcaa 1201 acgatacaaa cgtgacaaag gatagaagcg caattcagct cgaaataaat gagttggctg 1261 aggaagtaac cagaatagcc gaaaagaccc agttcaacac cagaactctg ttggccggtg 1321 gattgaaaga tgatggtgcg gttacaattc aaataggtgc caacaaggga gaaactttgt 1381 ccatagaaat aggaacaatg acagccgcaa aactttctgt atcaggtttg gtagttagca 1441 cttcggcatg ggctcagtca gctatttcaa agattgatgc cgcaattaac acagtatcaa 1501 cagagagagc aagacttgga gcgaaacaga acagattgga gcatacaata aagaaccttg 1561 acacagcagc agaaaacctg caggcgtctg aatcaagaat cagggatgta gacatggcac 1621 aagaaatgat gaacttcacg aagaacaata tcctcaatca ggctgctacg gcaatgttgg 1681 ctcaggctaa catggttccg caaggtgttc ttcagttatt gggctaatat gctattacta 1741 tagtatgaat aaatatggat aattgcaagg atgctgtgaa attcaaggag ggatgagtta 1801 tgagaattaa caacaacatt atggcgtaca acgcccacag acaattaaaa gtaaatgcgt 1861 cagcgcagga aaaatccttg gagaaattgt catcaggcta cagaattaac agagctggtg 1921 acgatgcggc aggtctgtcc atatccgaaa aaatgagagc gcagatcaga ggtctgcaaa 1981 tggcgtcaaa gaatgcccag gacggtattt cattgatcca gactgcagaa ggagccttaa 2041 ctgaaaccca tgccatcctt caaagaatga gagagcttgc agtacaggca gcaaacgata 2101 caaacgtgac aaaggacaga agtgcgatcc agctcgaatt gaatgaattg gctgctgaaa 2161 ttaccagaat aggtgaaact acgcagttca acactcagaa attgttggat ggaaccttta 2221 gtgcaagagt attgcagatt ggtgccaata aaggtgaaac tctttctatt gaaataggag 2281 atatgacagc tactgcgtta cacgtaaatg ctgataattt atctgtagaa acatctgagg 2341 atgcccagga cactattgaa ctggttgacc aagcaattaa catagtatca ggagaaagag 2401 cgaaacttgg agcgaaacag aacagactgg agcacacaat aaagaacctt gacacagcag 2461 cagagaacct gcaggcatct gaatcaagaa tcagagacgt agacatggca caagaaatga 2521 tgaacttcac aaagaacaat atcctcaacc aggctgccat agcaatgctg gctcaggcta 2581 accaagttcc gcagggcgtt cttcagttat tgggctaaat tataatgtca gattgtagtt 2641 tggcatggtt catcttaaca aaaaaaggcc ggcagggatt cttgccggcc ttttttaaaa 2701 catttgacag gcaggaggat tttatggttg acgtattcag acttaatatt gatgctttaa 2761 aggaaaatta tcttcctttg gcgcggtttt tcgaaaattt gaatgaaaat accggaaatg 2821 aaagtagtgt tatccttgag acctcaaaaa gcgggatgcc gaatttcagg gtaaaaaaag 2881 gagaacatac tttttttgtt catagcccgt atgatcccag aactgaagcg ataagatggg 2941 cagagaaaat tgatttaaaa ggttttgata caattgcggt tttgggtatt ggatgtggat 3001 atcatataga agagcttgaa aaaaagtatc ctgataaaaa caaaattgtg attgaaccgg 3061 acagaaatgt gtttttaaaa cttcttaaca caagggacat tacacattta atatccagta 3121 aaaacatatt atttataatc agtgacaata ccgaggaaat cgcaaaggtt ttcttgttgc 3181 tcagagaaga aggagaaata gacagtgtgg agtttaatga attgttaagt tacagaaaag 3241 tttatgagga ttggtggttg gaattaaaaa aggaatatat aaagtttgca agacttcatc 3301 agataaatac caatacgagt gttttttttg cggaagcatg gttaactaat ttatttgaag 3361 gaatgtggca gttgacaaag agtgtgcata tcaaggaata caaatctgct tttgccaata 3421 ttccggcaat tgttgtttct gcaggcccgg cattgaataa aaatgtacac cttttaaaag 3481 aactgtacaa taaggcggtt attatttctg ccggttccgc ccttaacatt ttggaaagca 3541 ggggcattac accccatatt atggttgggg tggacggcgg agaagcggaa agccgaatat 3601 ttaacaatgt taaatccaat gaaatatatt ttgcctattc tctttcggtt cattatgacg 3661 gattgaaaaa ttacagcggt cccaaaatat atttcaagac caatgtgctg ggatatggtg 3721 actggattga cgaaaagttg ggcattgaag gtgcggaaaa ccttcgctca ggttcttccg 3781 tgtcaaatct gtctttggac attgcgaggt atatgggatg caatccgatt attgtcatag 3841 gccagaattt gtcctttcca aacttggaat cttatgctga cggtgctgtg ttaaaacagg 3901 aacaggaccg gcatatccaa cagtgcgtgg aaaattcaaa taagtattat gtgcttgaaa 3961 aagatattga tggtaatgat gtatatacta ctcacagcat gctttccata agattttatt 4021 ttgaagagta tatcaagaac cacccggaca ggttgtattt gaacggctct gaagaaggac 4081 tgcctataaa agggatgaaa aacatgccct tgaaggagat tgtagaaaag tactgcacaa 4141 aggaatatga cattaaagga attttggata aaaaattcaa agaagaattt gaggcagaaa 4201 acgtaaaagc aaaagaaatt aaaattagaa gaattttgga agatattcac aaagaaagca 4261 ctgaaataag acaaaaagct ataaagagaa tagatttaat tctcgatata ttaagtaata 4321 tcagaggcag ccataatgac aagtgggagg aaattgacag gttgacagat gaaattgaaa 4381 gcagtgattt gtacaaatat ttcgttgaac ctttgagcaa atactttatt caggctgtta 4441 agaatgaaag ggaaagaaag atggaaagca ttcctgatat acaagagaga ttgaaatatc 4501 tgtatgaggg attgcttata cagtatgttg aggtaaagga caaaattgtc ctgatagacg 4561 atttgtccca aaaaataata gagaatattg ataaaaagga ggcaacaaaa tgtctaagta 4621 tggtttgaaa aaagaaattg taggcacggc ggctgaatat attgtaaatg tttccgaggg 4681 tatagaccag ataatagaat tttttcagag cggaagggaa gacatagcaa caagaatgat 4741 gattgacctg atagaaggaa ttgaatggct tacccaggct atagacggta ccagggatat 4801 ccacggagaa tatgcaatgg atgtttcaca gataaactcc gcattgcatg aaatatcaga 4861 agcctatgaa aatatggatt atgttttgct cagtgattta ctggaatatg agttgctgcc 4921 tgtaataaac gtatggagga aacaacttgc cggcataaag ggagtattgg ataatgacaa 4981 tgctgaagaa taatctggag ttgcttaaaa aaagatatcc ggaaatatat aatgaaataa 5041 aagacattca tgtggattcc aatgcgtatc agattataca aaacaatgaa ggacaaaaga 5101 ctttaaaggt gactttggac ctgtatggcg agaataaaag cttctttttg cacagtaaat 5161 atcatccgga tgttgaagca gacagatttg cgcgggaaca atacaaaccg gaattttcca 5221 tacaaattct ctacggattt ggattgggtt atcatgttga aaaaattgcc ggacttttaa 5281 aaccggacag catgctgtat gttatagaaa ataatttgat ggttttcagg tcggcattgg 5341 aaaacatgga cttatgccct attttggaaa atcggaatgt ttccctgatt gtttcaaagg 5401 atgttggcta tatatcggaa aaagttaagg aattaattga taacaacctt gacaaggtca 5461 gttttataac acatcccgct tcattgaaag caattcctga ggaaaacgaa tatttcaaat 5521 ttgtaatgga gaactggaat cttaagaaaa gtattaccga tgattatgac aatactttgc 5581 gcaataatgc aaaagaaaac ttaaagttaa acagtccgaa tgtaggcatc ttttttgaca 5641 agttcaaaga tgttccgata atcattgtgt ctacaggccc ttcccttgat aaaaacatag 5701 atttgcttaa agaggccaag ggaagggcat tgattatttc agccggttct gccttaagac 5761 ctctgcttat gaggaatata aagccggatt tctttgccat tattgacccg caggatataa 5821 cctacaacca gataaaggga tatgaaaata tcggtattcc ttttatttat ctggttactg 5881 ccgcttccta taccgtttca cgttacctgg ggccgaaact ggtggcttat tacggaaagt 5941 acaataatag ttcggaacat ttggtggatt cgggaggctc agttgcgacc actatactgg 6001 acatagccat taaaatggga ggaaatccta tcatattagt gggacaggac ctggcgtatg 6061 tcgacggaaa aaatcatgcc caatatggga gccatgccag catttactca cctgagctta 6121 aaaacatgag aagggtaaaa gggcaaaacg gagagatgct gtatacatcc ctgggactgc 6181 taagttataa atactggatt gaaaacagga tacaaaaaga gaaaagaata ttcataaatg 6241 ccaccgaagg cggagcttat atcgaaggaa tgaaacatat caagttaagg gacgtaattt 6301 ccgattatct aaaagaaagt ttcgattttg aaaataaaat aaaatccata ctgaaagaga 6361 gcgggatcca acatgttcaa ggataaaaag atattggtta tcggagggac aggctccatc 6421 ggacaagctc tgattgaacg tattctaact gaaaatcctg ccgtaatcag agtttacagc 6481 agagacgagt acaagcagtt tttgcttgcg gaaaagttca gggaaaacgc caatatcaga 6541 tatcttatag gcgacgtaag agatgaggac agactcgaca gggcaatgaa tgatatcgat 6601 attgtgttta atcttgcggc cttaaaacac gtacctgcat gtgagtacaa cccgtttgag 6661 gctgtcagga ccaatgttat cggaagccag aatgttatag cctgtgccat ggcaaacaag 6721 gtgaaaaaag taatttatac gagcagtgac aaggctgttt ctccaaccaa taccatgggt 6781 gcaacaaagc ttctggcaga aagactcatg tcatcatcca actattcaag aggaaacacg 6841 ggtacggtgt ttgcttctgt cagattcgga aatgtaatgg gcacaagagg ttcagtgatt 6901 ccgcttttca agcagcaggt tttggaaaag ggatatatta cggtgaccga accggagatg 6961 acgaggttta tgatgtccct ctcgcaggcg gtggaactta caattaaggc atgcagcatt 7021 gcaagaggcg gggaagtttt tgtgctgaaa atgcctgtaa tccggttaaa agacctggca 7081 gaagtgatta ttgaggatat gtgtaaaaag aacaatattg atcccgaaaa gatagagatt 7141 aaaaagattg gactgagacc cggagaaaag atgtacgaag aacttatgtc ggaagatgaa 7201 tcgacaaaag ccgtcgaact gaatgatatg tatgtaataa tgccaccttt tgaaaatagt 7261 tactatataa atgccagaaa ggcggttata ggcaattaca gttcacaaaa agaaaaaacc 7321 ctgaccaaat cacaaataag ggaactgctt gtcagggaaa aattaatttg attgtttttt 7381 tataattagt aaggtaatca aattaaaaag attttaaaat tatacaagct taaaagaaac 7441 ttttaaactt aaaaatgaaa aacagaaagt aaaaacaaaa cgacatggag gaaaaacatg 7501 atgaccaact tgcaggaaaa aacatgggca ggccagtttg gcaaagatta taccgacagg 7561 tgcacgtttt cacctgaaga gcttgacagt ttgtataaaa gagaatatgg cataagcagg 7621 gaggagatga acaccaggtt tttatcggga ttggggcttg agaacaagag aattttggaa 7681 gttgggtgca atgttggcaa tcagctgaga atgcttcaaa gaatgggatt taacaatcta 7741 tatggaatag aacttcagca gtatgccatt gaaaaggcaa aagctcttac caaacggata 7801 aatattattc atggagttgc ggacgatata ccttttaaag acggatattt cgacatggtg 7861 tttaccagcg gggtgttaat tcacatttca cccggcaata taaaccgggt gcttgatgaa 7921 atataccgct gcagccggga atatatctgg ggatttgaat actatgccga tgactatacc 7981 gaagtgaatt acagaggaca tgaaagtctt ctttggaaaa caaatttccc aaagctttat 8041 cttgacagat ttcccgaatt ggaactggtg aaggaggaaa aatttaaata tctgtataat 8101 gataatgtgg atgtgatgtt tttactcagg aagagaaaat aaccgcaact tgtcaaaaaa 8161 acaggaggag catatgaaaa caggggctgt tgtacaaaca agaatgggct caacacgact 8221 gcccggcaag gttatgatga atttatgcgg caagccggta atagaccatg tgatagacag 8281 gctgaagcag tcaaagcttt tggatgatat aattattgca accactacat cggagaaaga 8341 caaggtaata gtggaacagg cgaaaaaaaa cggggtaaaa tggttttgcg gcagtgaaga 8401 agatgtgttg tcaaggtatt attatgcggc aaaagaaaac aaccttgata cagttgttcg 8461 tattacttcg gactgtccgc tgattgatcc tgtgcttttg gataaagtgg tggaatttta 8521 tttttcaggc aattatacgt tggtaaccaa tgcaggaaat gatttgaccc agagaacata 8581 tcccagaggg cttgatgttg aggtattttc ctttaaagta ctggaagatg cctttaataa 8641 tgctgataaa agctatcaga gagagcatgt tactccctat atgtatgaaa cttatggtca 8701 aagtgtatac tactataaaa ataacacgga ttattccaat ctcagatgga cactggatac 8761 aatcgaagac tttgagttga ttgcaataat ttatgataaa ttatatgaca aatataacgg 8821 aaaattcgga tttgaagaag tactggaatt tataaaatcc aatccggaac tttgcaaaat 8881 caatgcacat gttgagcaga aaaaagtgat gtgaaatatg gggcagggaa aggattttgt 8941 ttagctaata aatttgtggg ggtaagtata tatgcagagc agaagaatta aaatagggaa 9001 tcgggaaatt ggtgaaggat gtccctgtta tattattgcg gaaatgtctg cgaaccatgc 9061 aggagattta ggcagagcaa tcgaaataat acatgcggcg aaagaagccg gggcggattg 9121 cataaaaata cagacttata caccggatac catgaccata aactgtgata aaaaatattt 9181 tcatataaat gacggaacct ggaaaggtga aaatttatac ggtttgtacc agaaggcaaa 9241 tactccgtgg gaatggcacg cacggctcaa agaagaagcc caaaaagcag gaattgattt 9301 tttttcaact ccgtttgaca aatcggctgt ggattttttg gaggatttgg gagttgaatt 9361 ttataaaata gcttcttttg aggttgtaga tattcccttg ataaaatata ttgcatcaaa 9421 gaaaaaacct attattatgt caacaggtat ggcaactttg ggtgaaattg aagaagcggt 9481 ggaaaccatt aggtcacagg gtaatgacaa cttctgcctt ttaaaatgtt ccagtgctta 9541 tccggccgtt ccggaacaaa tgaatttgaa aaccatagct catttgaaag agacatttaa 9601 tgttcccgtg ggattgtcgg atcattcttt gggttcggtt tctgcagttg tggcggttgc 9661 catgggggca agcattattg aaaagcattt ttgtctgagc agggaaatta aaagtcccga 9721 ttcgtccttt tcaatggaac cggatgaatt caaaaagatg gtcgaagata taagagctgc 9781 ggaaaagtca atagggaagg taagctacag tatttcagaa aatgaagccg taagccgcag 9841 tcacagaaga tcgatttttg ttgtgaaaga tataaaaaag ggtgaagctt ttacagaaga 9901 gaacataagg ataataagac cggcagacgg tttggagcca aaatactttg agcaggtttt 9961 aaaccggagg gcgtcgcagg atattgagag ggggacaccg ctgaagtgga caatgataag 10021 ctgaaagacg gatatgtgaa ttttataaac attcttaatc ttgacgatat gtacgtaaaa 10081 aagatgagag agtggcgcaa tcaggatttt gtaaggcaga gaatgtttaa ccgggaaatt 10141 attacggaag aagaacatgc gagatttatt gagcatttga aggataacag ggaaaaaaat 10201 tattacgttt gttttttagg caacaaaccc tttggagtat tgtattatga gttttttaga 10261 aagaataaca atcttgaatt cggttattac ctgactgagc aggaatttat aaacagcggt 10321 cttgggatag ttatggaata ttcattgtta aaccatgcgt tttatgactt gaaggtaaat 10381 aaagtgtttt gcagaacact gtcgagcaat gaaaaagttg taagcttgca tatgaacttc 10441 ggttttgaga cggaagggat acttaggcag catgttagaa taaatgacgg ctatgaggat 10501 ataacaatac aggctataaa cgaaagagcc tgggctcaga acaggccaaa gattgagaaa 10561 tatcttagag tgatagtgga cgttgataaa ataggtccta taaccgggag gagctgatta 10621 ggatggaaaa gctgatagaa ctggtggcgg aagtattgaa tcttgacaaa gaaagtataa 10681 gtcttgaaac ttcaagagag aacacttcgg catgggattc attgaatcac atcaggttgg 10741 tggccgaggt cgaagaacgg tttaatataa aaattccttt tgaaaaggtg ccgtatataa 10801 aaaaagtggg tgattttcta gaatatatca gggagtgatt actttgaaac tgtccctgct 10861 ttcaaacgta aatctggatt ctcttattag cagattgtca aagcagtatg atgtgtataa 10921 aactgaagga tatgggacat ggatacagga gataataaat cctgattccg gattgtattc 10981 atttgggccg gatatggtct ttattgttct tgacggagaa gaaatgttaa gaggccagag 11041 tgaaagcaac gaaattattg acgtaaatat aaactatatt gaagaagcag tgaagaataa 11101 tcccaatata accttctttg tgagcaatat tgatttgtgg acggcaaaaa ttgaaagtgc 11161 gaaatccggg tcaaaggaaa gaaggcttga attcctgtgg gaagacagcc tttttttgct 11221 gtgcgaaaaa tataaaaatc tttatgtttt tgatataaaa agcattgtgg aggataaagg 11281 aagagaacaa ttttattcta aaaagctgtg gtatttgggc ggaataaaat attccatgaa 11341 ggcggaaaaa ttgctggagc agtatattaa cagatgtgtt gcttctttta agggtaaaag 11401 aaaaaagtgc ctggttttgg acctcgataa caccttgtgg ggcggcgttg taggagaagc 11461 cggtattgag gggattgaac tttcggatta caaggaaggt gccagatata aggattttca 11521 aaggaaactc aaggaaataa aagatttggg gataatactt gccgtggtat ccaaaaacaa 11581 ttttgatgat gccataaagg ttataaggga acacaagcat atggtgttaa aagaggaaga 11641 ctttgtcgcg ctgaaaataa attgggattt gaaatcccaa aatataaggg atttatccga 11701 agagctcaat attggacttg attccatggt gtttattgac gataatccgg tggaaaggga 11761 aagtgtaaaa agggagcttc ctgaggtggt tgtaccggat tttccgcagg acagttcgga 11821 acttgtggat tttgcaactg aactttacaa taattatttc tatacattgg acacgactta 11881 tgaagatacc gtgaaaaccg aaatataccg tcagaatatg aaacgaaggg acgcacaaaa 11941 atccagtgct tcgtatgaag attttctaag gtctttggaa accaggattg agattcgcag 12001 aataaatgcg gaaaatgttc agcgggctgc gcagcttaca caaaaaacca atcagttcaa 12061 cttgactaca aaaaggtata gcgaacagga acttctggct ttaataaatg accaaggatt 12121 tgaaggattt gtggcttatg tcagtgacaa attcggggac aacggaatgg taagtgtggt 12181 aataacaaga cgcaaaagcg acagcgaagt tgaactggac acctttttgc taagctgtag 12241 ggtcatgggc aggtttatcg aagaccggat aataggtttc attgaggatt tatataaaaa 12301 agccggttat aagaaattca ttacatatta caggccaacg gaaaaaaacg ctccggtaaa 12361 ggatttgttt gaaaggctgg gttatacgct tttggatgtt gacccagaag gaaataaaaa 12421 atatgttttg gatttcgaaa ggttaagtga gtgttccaga aaagaattcg gggagctgat 12481 agcattatga aaatacatca tgtgggatat gcggtcaaaa atatggaaac ttccattgaa 12541 gagtttctta aaatcggata caaaaagcgc ggagaaactg tggctgacga agcaagaaag 12601 gttttaattc aatttatgga acttggggat tattgcatag aactggttgc tccaatggat 12661 gcggattccc cggtaaacag cattattaca aagtcaggca atactccgta tcatatatgt 12721 tatagcgtgg ataatattga tgaggcaata aaaaaactga aaacagaggg ttatatcctg 12781 atggaaagtc cttccggtgc ggttgccatt gatttttgca aagttgcttt cctttacaac 12841 agggatgtag ggataattga attggtggaa gaaagtacac aatgcggtgc acggtaaatg 12901 aagtttataa cgaggtgagt attatgaaca taattattgc caccacaaag tcatggaaca 12961 taaaaaatgc gcaaaagttt aaaaaagaaa acgagtcaaa gtacaataca actataatta 13021 cgaataagga tgaacttact tttgaaaaag taaagcttat taaccctgag tatattctgt 13081 ttccccattg gtcatggatt attccgaagg agatatttga aaactttacg tgtgtggttt 13141 tccatatgac ggacctgcct ttcggaaggg gaggaagccc acttcagaat cttattgaaa 13201 ggggaatcaa gaaaacaaag atatctgcca taaaagtgga cggcggaata gataccggag 13261 atatattctt taaaagggat ttggaccttt acggtacggc agaagagatt tttatgcggg 13321 cgtctaaaat aatatttaac gacatgattc cggaacttct cacaaaaaga cccgtaccgc 13381 aaaagcagga gggtgaagcc acggtatttc agagaagaaa accggagcaa agcgaaataa 13441 gcccggattt tgatttggag aaaatatatg attatatcag aatgctggac ggagaaggat 13501 atcccagggc atttattaaa tacggaaagt acaggctgga attttcaaga gcatccatga 13561 aaaacggaaa aattattgcg gacgtggaaa taatagaggg tgacgaaaat gagtaatata 13621 ttggttgtgg cggcacatcc cgatgatgaa ctgcttggag tcggaggtac gattcgcaga 13681 cacgtcaata acggagatgt ggcagattgc ctgattttag gcgaaggtat gacttcccgg 13741 gcggaaaaaa gagaagattg ggacaaaaac accttaagtg agctgaaaag tcagacgctg 13801 aaggccgctg agattcttgg atttagaaat gtttactttt ccgattttcc cgacaaccgg 13861 tttgattccg tggatttgct ggacattata aaggaagtgg acaagtatat tcaaagactc 13921 aaacctcaaa taatatatac ccatcactat ggagatttga atattgacca cagaagaacc 13981 tttgaagcgg taattactgc ttcaaggcct gtgggagaat acccggtaaa agaaatatac 14041 tgttttgaga ctccgtcatc cactgaatgg aattttaaat atggaggcaa tgtatttaaa 14101 cctaatgttt ttataggtat tgacgataca attgatgcca aacttaaggc tatggagtgt 14161 tataaatccg agataagaga ttatccccat ccgaggtcga taaaagcatt ggaaataatt 14221 gcagcaaggt ggggaacggt agtgggcaaa aaatatgcgg aagcctttga attgatcaga 14281 aaagttgtct gagaggttga tatgctgaat ataggaatca gagttgacgg aagtgccaat 14341 atcggcatgg gacatataat gcgctgcctg tcgctggcaa aaggatttag aaatgccggc 14401 gccaatgtat atttcttaag ccggtttgaa cagggaattt caaggataag gcaggacaac 14461 tttgaagttt tggaaatgcc gtaccgaaaa agcaggaatt cgggaggctt tttctatgga 14521 gatgcttcgg agctggagga agacgcggaa gaaataatct gccgaattag agcatttaat 14581 ctggatgtgc tgattattga ctcctataac gtcagccggg agtttttttt gaagctgaag 14641 ccgcatgtaa gaaagctttg ctacattgat gatcttaata aatttgtata tcctgtggat 14701 gtgctgataa acggaaacat tacagcccca gcattaaatt atgccaaata cagcgatgac 14761 gagcttatgc ttttgggctt gaaatataat ctcataaggg atgaatttaa aaatttgccc 14821 gagagaataa taaacaggga tgtgcgggaa ataatgataa caacaggagg ctcagaccct 14881 tttaacctga ctctgaggct tgcaaatgcc atcctgccgg aagaagaatt taaagatgtg 14941 agaatcaata ttgttgtggg cagcggtttt accaatgcgg acaagcttag agagctgtcc 15001 gaaagaaacc cgaatgttgt attgcatgaa aatgttttgc gaatgtcgga agtaatgcta 15061 aaatccgatg ttgcaatatc tgcaggggga agcacattgt atgagctttg cgcctgcggg 15121 acacctgccc tggctgttgt tattgctgat aaccaaaggg aaatggtgga tatgttgtct 15181 tccgaaggtt acataatcag cctgggctgg catgaagagc ttgatgacag ggagcttttg 15241 cgaaaggtta agtctttgtg cggggattat gaaaaaagag tgcttttcag cagaaagatg 15301 caaaagctgg tggacggaga aggggtaaaa cgtgtggttg aggaaataat gaaaataact 15361 tcgtgaaatt atcatttcct taaatccacg ttatacaaac tacattttac agggagaaat 15421 acatatggag aaaagtgcgg agcagaaatt cataccttac gggtgccaat ggattgagga 15481 agatgatatt aatgccgtgg ttgaggtatt aagaggagat tatctgacca cgggccccaa 15541 agtaaaggaa tttgaagaaa atctggcacg gtataccggt gcaaagtatg ctgttgccgt 15601 gtccaacggt actgcggcac ttcatgcggc atgttttgcc gccggaataa aagaggggga 15661 cgaagtaatc acaactccca ttacttttgc cgcttctgcc aactgcttgc tgtatatggg 15721 ggcaaagccc gtttttgccg atattgatcc tgatacatac aacattgatc cgaaagaaat 15781 cagggccagg attaccgaaa aaaccaaggc aataataccg gtgcatttta ccggccagcc 15841 ctgtgatatg gatgaaatat tgaaaattgc agaagaatac aatcttttgg tgatagagga 15901 cggagcccat gccctcggag cggaatataa aggcagaaaa atcggaagtc ttggagatat 15961 gaccaccttt agttttcatc cggtaaagca tattacgacc ggtgaaggcg gcgcaattgt 16021 gacaaacagc gaagaattgt ataaaaaact cactcttttc aggacgcatg gaataacgag 16081 ggaaacggga gatttattgg agaaccatgg cccgtggtat tatgagcagc agtatttggg 16141 ctataattac agaatgaccg atattcaggc tgcattgggc ataagtcagc taaaaaaatc 16201 cgataaattc ctgcaattaa gaagagatta tgcaaagctc tacactgaag cttttaagtc 16261 cgttgatgag gtggttgtgc cgtaccagct tgacggtaca gactcctcat ggcatttgta 16321 tatcttaaag ttgaaaacgg aaaggcttaa ttgtgacaga aagaagatat ttgaggagct 16381 taaggaaaga cggataggag taaatgtcca ctacattcct gtgtattacc atccgtttta 16441 cagaaaactg ggatataaaa aaggtttgtg tcctaatgct gaagattttt atgaaagaat 16501 aataaccctt ccgctgtttc ctaagatgga aaaggaagat attctgtatg taatttccaa 16561 tgttaaggac gtaattcaaa aacatatcat atagaaagga tgattgagct tgaacatatt 16621 ggtaactgga ggagccggat ttatagggcg ctgggtggtt aaaagacttt tggaggacgg 16681 acacaaggta tgggttttgg acgacctttc caacggtcag cgcaaaaata tcgaagaatt 16741 tctgtcaaat cccaactttg ccggatttgt tgaaggtgac attaaaaaca ttcctgttct 16801 tgaaaccctt tttgaaaaca agtttgacat atgctatcac ctggcggcga gtattaacgt 16861 gcaggacagc attgacgacc cgggtacaac atttcaaaat gatgtggtgg gtactttcaa 16921 tgtgctggaa caatgcagaa agcacaacac taaaattgtt ttcatgagca cctgcatggt 16981 gtatgacagg gcaaacgatg aaaacggaat aaccgaggcc catcccacaa aaccggcctc 17041 tccctatgcg ggcagcaaga ttgcaggaga gaatatggtt ttgtcttact ggtacgccta 17101 taagctgccg gcggtggtta tacgcccctt caatacttac ggtcccatgc agaaatccag 17161 cggtgagggc ggcgttgtgg cgattttcat aaggaggaat ttggaaggac ttcctctcaa 17221 tatatatggg gacggatgcc agacaagaga tcttctttat gttgaagact gtgcggaatt 17281 tgttgtacgg gcaggatatt ccgacagagt aaacggagaa ataataaatg ccggactggg 17341 aagggatata agtataaatg atcttgccct tttgatagca aaggacaaag aaaaaatagt 17401 acatgtgccc catattcatc cccaaagcga gatagcgaag cttctgtgca actatcaaaa 17461 ggccaaagag cttttgggat ggacaccgaa agtttctttg gaggaaggca taaaaagaac 17521 cgaagagtgg ataagaagca cgcttgcaac ttaatgctaa attaatttta ataatcctcc 17581 gatatttttt atgagaaaga ttcacggagg gattattatg aaaattgaaa gcatggatgc 17641 tgcaaattta caggttctga aaactcagtg caaagattat cagcctaata ctgtaaattc 17701 tagcaacaat tttggtaaag aagcatcgaa tgagaaaaaa acgcatgtgg atgtatctgt 17761 gtcgggaaac gaaagcgaag caggtttgtc acaaagggta attataaagg caattgagaa 17821 ggcaaacaag gctataaacg gtattcatac agaactggaa ttttccatac acgagaaaag 17881 taaagaaatc atggtaaagg ttattgattc cgagaccaag gaagttataa gggagatacc 17941 gccggagaaa atattggata tggtagcggc aatgctggaa atggcaggaa tcatagtgga 18001 tgagaggggt tgaaatcggt ggcggtcaat aacatatcaa atttgatcaa cagcagaata 18061 agattgacag gtatatcctc gggtcttgat accgatgcta ttatagaaca gctcatgagc 18121 gttgagaggg caaaggttga caagataaaa caggagaagc agatactgga atggaagcgg 18181 gatatataca gggatataat aaacaaattg agaagtatta cagatgagta tttcaacgtt 18241 ttgaagccca aaacaaattt tacttctcaa agtgctttta catcctttaa aataagctca 18301 agcaatgagt cagttgttac ggtaaccgcc aatgcatcgg cggcttccaa ggttcacagc 18361 ataacggtgc actcccttgc gtctgcggca aagattgtag gtacctcagg attggttgac 18421 ggtattaaag ggagtaacgc ggtaaacact ttgtcgcttc agggcaaaga aataaatgtt 18481 accctggacg gagttacaaa gacaatagcg ctggaggatt ataccagcct cagtgacctt 18541 gaaacaaaac ttgagtctgc cctggcaaaa gcctttggaa cgggaaagat agatgttgtc 18601 acaacaggcg gctcgataga gtttaaatgt cttttaaacg gcagtacatt aagtataagc 18661 gatacagcaa acaactatat ttcatcttta ggtttttcca atggacagaa aaatttcatt 18721 acaggaaatt cggatgtaaa ctccgatttt tcattatata ccgacggcag ttttaaaata 18781 acagttggaa acggcacggc gcaaaccata aatatttcag atgcaacgag tatagatgac 18841 cttgtcgcaa aaattcagca agccattgac agtaattcag agctgagcgg taaagtgcat 18901 gtgagcaatg acggaagcaa attaaccttt atttctgttt cgggagaaac agtgaagctg 18961 acttccggag attccaacaa tgtgctggac aagctgggat tttccgacgg agcaactata 19021 actgcaacaa gctcgacagt tattgatttg agcggaaatg aaaagggtaa aacttttatt 19081 attaatataa atggcgttga caaaatcatt gaaatagaca aggactataa tgatttggat 19141 gagctggcat cgtacattca gaaccagctg ggaggcactg taaatgtaac aaaagatgct 19201 tccggcagca gacttgtttt ttcaaccgga ggggcggaca gactgatatt taagaagggt 19261 cccgaggatg gactggaaaa gctgggattt accgcaaatg acaacaggag caacaggata 19321 tctttaacga caaagcttga ttcattaagc acaattttca aaaatgattt gaatattgca 19381 gatcctgatg ccaatgttgt tttcaccata aacggtcaaa ccattgatgt gggcaagact 19441 tatgcaaatg caacattaag tgatgtaatg aatgccatta attccagcag tgcaggggtc 19501 aaaataacct atgactccct caacgacagg tttattatgg aatcgaaaac tatgggagcg 19561 acttcggaaa tagaattaac cgatacagac cctgccaatg gtttgttaaa agccatggga 19621 cttatcggag gaacctatac tgccggtacg gatgccgagt ttgacttgga cggggttacc 19681 ggcatgaagc gaagcaccaa tgaatttacc atagaaggag taacctactc acttaaggga 19741 gtctcttccg aaccggtaaa gattgatgtt aaggcggaca tagatgctgt tgttgaaaat 19801 ataaagaatt ttgtgaacag ctataatgaa atgcttgcca aaatcaactc tgtgcttacg 19861 gaagaaagat acagggatta cctgcccctc acggacgacc agaagaaagc aatgagtgaa 19921 gacgatataa agttatggga gcaaaaagca aagtcaggtt tgctaagaag cgacagcata 19981 ttggagaata ttgtgacaaa cttgaggaga gctttatatg acaaggtgga aggatgttcc 20041 ctgagccttt atcagatagg aattacaacc ggatcatacc aggataaagg aaaacttgtc 20101 atagacgaag aaaagctcag ggcggcactt actgataatt atgacgcagt ggtccagctc 20161 tttacccagg gctcacaata tacatacagc gaggctttaa acgacccgaa caaaagggct 20221 gtaagataca aggaagccgg aatagcccaa aggatttatg acatactcca ggacaacata 20281 aggataacaa gaaatgccaa cggaaagaaa ggtatcttgc ttgaaaaagc gggaattgca 20341 ggagatttga cggaatatga caacttaata gtgaatgaaa ttaaggcaaa agagaccttg 20401 attgacgaaa tgcttgtaaa aatctataaa aaagaagaat attattacag caagttcgcg 20461 gcaatggaaa aaatgctcga tgcaatgaac agccagtcaa tgtggttgac gcagcaattt 20521 tcaaattatt attaaagcgg agccgtttga atgaaagcaa attcagagct ataacttata 20581 aacctttgga gggatcttaa tggcattaaa aaatgcatat gaccagtaca aggagaattc 20641 ggtgtatacc gcctctcctg aagaattgac attaatgttg tacaacggcc ttgtaaagtt 20701 tttgatgcaa gctcaaatgg cattaaatga taaaaacatt gaaaaggcaa acaaaagcat 20761 tatacgggct caggatatta tttcagaatt tcggtgtaca ctggatatga aatatgatat 20821 tgcgcatcaa ctggatcttt tgtatgacta tatgtacaga agacttgtgg atgcaaatat 20881 aaagaaagac ggcgcaatcg ttgaagaagt tctgggcttc gcaaaggaac ttcgggacac 20941 atgggaacag gcaatgaaaa ttgcaaaaca gcaaaattca agaacggctc aagtggctaa 21001 ataggaggat tttaatgaac ggtaccccgg aaggttatat ccaaagactt gtcgaaatat 21061 ctaaaaaaaa gatggattgt ctcaaaagca ttctttcgtt gacgagggct cagaccgagg 21121 cgataagcga agaaggcatg gacgggcttc aaagtcttat tgaccaaaag cagagtaaaa 21181 ttgatgaaat caacggtttg gacgaagaat tcaatgcgtg ttttacggcg ctgaagcaaa 21241 agcttggtgt aaaaagcctg gatgaagcag ggacattggg cataaaagga gtaaaagaac 21301 tgcaaagcct ggtttcaaag ataatggggc ttttaaaaga aataagcgaa gtcgaaagga 21361 gcaacaaaga aaaggcaaac agccttttga gctttcttgg agctaaaatc agggaaataa 21421 gagaaggaag gaaagtaagc tccgcttata gcccggctgc ttcgttaagt ccgccttcat 21481 attttatcga ccaaaagaaa tagttttgga cctcggattt tccggggttt ttattttgct 21541 ttgttgtttg ttccgttatt tgttcagtta aattatgttg acggttgaca ttagcatctt 21601 ttattgaata taataatatt ggcaattgaa tatttttgtt aggtgaggct cctatacaga 21661 aagacgctgc tgcccggaaa cgtcgaaaga cgccaatggg taaacaggca ctaccggatt 21721 aaggttttgc ttaatgcagc tggtgttgca gcctaagctg tatagtgcca aagctcaacg 21781 agggaaagat ataataagat tgtattttaa tgggctttat aacttccact cgtatggaag 21841 ttttttattt gggtatattg cagaaaatat aaaaaattct attttatgcc tttacagggg 21901 agtgaaaggg atgatttacg atgattgaaa tatacaaatc ctatgataca gacttgtttc 21961 ccgttaaaat tgacagcttt gagaaagggt gctggataaa tattgtttct cccacagagc 22021 aggaattgaa tttcgttgaa accagtctta acgtatcctc caatttttta agggaccctc 22081 ttgatgaaga ggaaaaacca agaatagatg ttgaggacaa ccagaccctg gtaattgttg 22141 acgttccgta tgtatatgag gaagacagag atataaagta tgagaccata cctttgggta 22201 ttatcatatt ggaagattat tttattacca tatgcagcaa ggaaactttt ttgattcaat 22261 acttcaagga caaaaaagta aaagattatt ttacttttaa aaagacaaga tttaccctgc 22321 aaattttgta tttgattgca aaagacttct taaagtacct gaggcatatt gacaaaaaat 22381 cgtatgaggc ggagacttcc ctgcacaagt ctcttcaaaa caaggagctt tttaaactgc 22441 ttgaattgga aaaaagcctt gtgtttttca ctacatcttt aaaatcaaat gagatagtta 22501 tggaaaaact tttaaaaggc aaatatataa aactttatga agaagaccag gaccttcttg 22561 aagatgtaat catagagaac aagcaggcta ttgaaatggc caacatttac agctctattc 22621 tgagcggaac aatggatact tttgcctcaa taatatcaaa caacctgaat gttgtgatga 22681 aggttttgac ttctataacc ataataatgg ccatacccac catgatagcc agtttcttcg 22741 gtatgaacgt acaaatgcct tttggccttg ataccaataa tccctatgcc ttttggggga 22801 tacttgggat ttctgcggtt atttccgttg ccgcgggaat attcctttac aaaaaagaca 22861 tgttttaagt ctgtgacagt ttttcaagaa agtccgttac cttttttacg tattcttcgg 22921 gatttgcctg ataaatttcc tcatgatctg caccgcttgt ttcccaaaac gtggtggtgt 22981 aaggattgga tgccttgtat atcaggcggc tgttttcaac cggcactttg gtgtcatcct 23041 tgctgtggat tagaagcaca gggcgcggag aaacagcctg tacggctttt acagggctgg 23101 cttcgtcggg cttgatatct gccagaaaaa atgttgcaaa tgttattgtt ttgttaaacg 23161 gtattgccgg aaagttggtt aaattgttta cgttttgttc aaaataagtg ttaaggtcag 23221 agtatgggct ttctgctatt actgcgtcaa catcgtcgct ttcggcagct gcgagaatac 23281 atgccgatgc tcctgttgag aaacccatga gaactatttt ctccgaacct ttgtttttaa 23341 cgtattgaat tgcaccaagc aaatcattct tttcacaaac tccgaaagta gttttatttc 23401 cctcggattc tccggagttt ctgaaatcaa aggcaagtac gttgtatcct ttgtcaagaa 23461 ggctctttat gagatgtatg gtgttctcgc caaaattcag cctgtttttt ccgtatccat 23521 gggcgaggat tactgtcttg ctgcttccgg ttacattaaa gtaccatcct tttaattcaa 23581 actcatcgtt tatgtctttg aaagaaacat cagtataaga aggtacgata ttggcggaaa 23641 agtccaaaat attcaatctt ttaggatgaa tcagtttcca tcccgcaata accgacacag 23701 ccgaaaccac aacagaaaaa atcaacgcga gcaaaacaat aaacaatatg atttttctta 23761 ttatatgact tttttggcgt gaataggtca aaacagtaat tctcatggac tttcccccaa 23821 aaaattgact tacttttcaa tttaagggct taaaataacc ggaaagatat tttctgactg 23881 aaaggatgaa tcaaatcata cgcatattgg aaccataagc tgtgagcatt gcaaatatgt 23941 gctgcatatg gtatcggttt tctgctgtat taatttgtat atttgtttac ttttattata 24001 caaattaaat atgaaaaaaa caaatttatt tttgaatttg gaatagaaag gaatgatttt 24061 tcaatggaag ttatattccg ggattttctc tggaagtaat agaatgttga ccattgcgac 24121 gcgtataaga tagaattata tgtgacacgg agttgagagg atgattcaat caatatggag 24181 ggcatagtaa attcgggact gtttaattgg cttatccttc cgctgcttat attcttttcc 24241 agaattatcg acgttacaat aggaacaatc agaattatat ttgtctcaag aggaaagaaa 24301 tatttagctc cggttttggg cttcttcgaa gtactggtat ggattatggc aataagtcag 24361 attatgcaga atctcaataa ttttgtatgt tattttgcct atgcggcggg ctttgccacg 24421 ggaacttttg tggggataat tattgaagaa aagcttgcca taggaaccct tgttataaga 24481 gttatcgtgg acaaaaacga atgtgagctt aaagaaagac tttcaaagtc cggatttggt 24541 gttacggttg tggatgccaa gggtaaaaat ggagatgtga agataattta tacaattata 24601 aagcgcaagg aattgcagga agtggtccga ataatagaag agtgcaattc aaaagccttt 24661 tattcaattg aagatgccag aaaggtcaat cagggtattt tcaggacagg tacgtcaaac 24721 catgatggga caaggttttt taatttgttt cggattcaca ggatgtccgg acttgacaaa 24781 aaaaccaggt aggatgctgt tagtgcccgg atggtaaagg ttaatggggg gtgggaaaat 24841 tggataatag taataataat attcttccga aggcatggga aagttttctc agttcatcaa 24901 cttttattcc ggttatagtg aaaaccattg agaggtttca tgataccagc tggcatatgg 24961 aaccgaacaa gcatgaatgt ttcgagatgg tgtatataaa aaggggcaag gctgtttttg 25021 agatagcagg ttatcctgcg gagataggcc ctaatgacat tattataata aagcccaatc 25081 agccccataa atttattgta aagtccgagt ccggatgcga gtttatagtc ctgagcttta 25141 aatttgtaaa ccggtttgac ggccagtatt ccgatgtgtc ccttgaaaac tttttggact 25201 ttgtaagcgg gaaggaaaca ggacctttta taaccctgaa agtcagccaa aagaacgata 25261 ttatagtgct tttaaacagg atactcaaag aaagggagaa tcctgacata ggaagcgagt 25321 ttttaaacta tcttttggtc atggagctgt ttgtgcttat ttcccgtgct ttgaagatgg 25381 aatgggagaa cagcataaaa aacaaaagcc cgaagataaa ggagcttata caggcttctg 25441 taaactatat aaacaacaat tatgagaggg atatttcctt aaaggatata gcccggtatg 25501 tttttctgag cacaagttac tttactcggg catttaagga agaaatggga ataagtccga 25561 taaattatct tttaaaaata agagtggaaa gggcaaagga acttcttaag gataccgaca 25621 acaggataag cgacattgcc ctaagtgtcg gattttccaa ccagcaaaga ttcaatgata 25681 ttttcaaaaa gtatgtaaag cttacacctc ttcagtacag aaagaatgta caagtcaaaa 25741 aacattaaaa atggctctta aattaggata aataacgaga agaaaatgaa attggcataa 25801 tttataatta gtattaaata tgaaagggat aagagggcat gaaagcttta tcatatttta 25861 aaggaggtag tggattatgg gaatgactat gacacagaaa atacttgcag atcacgcagg 25921 tcttgacaag gtttcaccgg gtcagctcat aaaagcaaaa cttgacatgg ttttgggaaa 25981 tgatataaca acacctgtgg ctgtgaagga atttagaaaa attggcgtga acaaggtgtt 26041 cgatgtaaat aaaatagcaa ttgttcctga ccattttaca cccaacaaag acatcaagtc 26101 cgcggagcag gtcaagttta tcagagaatt tgcaagggaa atgggaatag taaacttctt 26161 tgaagtcgga caaatgggtg ttgagcatgc cctgcttccg gaaaagggcc ttgtagttcc 26221 gggagacgtg gtaataggtg ccgactcgca tacatgtact tatggagctt tgggagcttt 26281 ctcaacggga ataggaagta ccgacatggc tgccggaatg gcaaccggag aagcatggtt 26341 taaagtgccc gaggccatga aattcgtatt gaagggaaaa cccggaaaat gggtgagcgg 26401 caaggacata atccttcata taattggaat gataggggtg gacggagctt tgtaccgctc 26461 catggaattc acgggagacg gtgtggccca cctttcaatg gatgacaggt ttgcaatggc 26521 gaacatggcc attgaggcag gagcaaagaa cggaatcttt gaagttgacg aaaagacaat 26581 tgagtatgta aaagaacatt ccacaaggca gtacaaggta tacaaggcgg atgaagacgc 26641 agaatatgtg gccacttacg aaattgacct ttcacaggta aaacccacgg ttgcgttccc 26701 gcatcttccg tccaatacaa gaaccattga caatgtgggc aatatcaaaa tcgaccaggt 26761 tgtaatagga tcatgtacaa acggaagaat tgaggatttg agggtggccg cggaagtcct 26821 caagggaaga aaagtgcaca aggacgtaag atgtataatc atccctgcaa ctcagaagat 26881 atggaaacag gcaatgaatg aaggtctgtt tgacatattt attgatgcgg gagctgcggt 26941 aagtactccc acctgcggac cgtgtcttgg aggtcatatg ggtattctgg caaaaggaga 27001 aagagctgtg gcaaccacca acagaaactt tgtgggaaga atgggacatc ccgaaagcga 27061 gatttacctc gcaagtccgg ctgtagctgc ggcatcggct gttttgggaa gaataggttc 27121 accggatgaa ctttaatctt aaatcatata tgcagagagt agaatatgtt gaggtaaagg 27181 agcgtggtaa aatgaaagca cagggaaaag caataaaata cggtgacaat gtggatacgg 27241 acgtaatcat accggcaagg tatttaaata cttcagatcc caatgagctt gcgaagcact 27301 gtatggaaga cattgacacc gaatttgtgt caaaggttca aaagggagat atcatggttg 27361 caggtaaaaa cttcggatgc ggctcttcca gagagcatgc ccctattgcc atcaaggcgt 27421 cgggaatatc ctgcgttatt gccgaaacct ttgcaagaat tttctacaga aatgcaataa 27481 atattgggct tccgattatt gagtgccctg aagctgccaa agatatatcc gacggtgata 27541 tagtaagcat tgattttgac accggaaaaa ttgtgaatgt gacaaaaaac aaggaatata 27601 cgggagtgcc tttccctgaa tttatgcagg aaataattgc ttccgacgga cttatcggat 27661 atattaaaaa gcagattgga aacaaggagg cataacatgg gaaagtataa aatagcggta 27721 cttccgggtg acggtatagg gccggaagtt attgaacagg cggttaaggt aattgaagct 27781 gtgggtgaga tatacaatca cagttttgaa ttaaaagaag gcctgctcgg tggatgtgcc 27841 attgatgcca ccggcgagcc cttcccaaaa gagacactgg aactctgcaa gtcctctgat 27901 gcagttttgc tgggggccgt aggcggaccg aaatgggata accttccggg ggacaaaaga 27961 cctgaagcgg gtcttcttgg aatacgcgga gcattgggct tgtatgcaaa tttaaggcct 28021 gcggttatct atcaggcact caaaggtgcg tcgccactgc gctccgatat tgtaaaagac 28081 ggcattgaca taatggtggt aagagagctt accggcggta tgtattttgg cgaaagagga 28141 agagtgcaga cggagaatat gggtcaggcc gcttttgaca cagaaaagta cagcgagttt 28201 gaagttgaaa gaattgcacg gctggcgttt gagacggcca tgaagagaaa taaaaaactc 28261 acatctgtgg acaaagccaa tgtactggaa agctcaagac tttggaggga agttgttaac 28321 agggttgctt cagactatcc ggaagttgag cttaatcata tgtatgtgga caatgccgcc 28381 atgcagctgg taaggaatcc tgcgcagttt gacgttatag ttacatcaaa tatgttcggt 28441 gatattctct ccgacgaggc gtctatgatt accggctcaa taggcatgct tccttcggca 28501 agtcttggag aaggctcatt ggggctttat gaaccaatac atggttccgc gccggacata 28561 gcggggcagg acaaagcaaa tcccattgcc acaatacttt cagtagctat gatgatgaaa 28621 tactccttcg gtcttgaaga tgctttcagg gctattgaaa atgccgtcgt aaatgtgctt 28681 ggcatgggat acagaacggc ggacattgct tccccggata ctcctcgtga gaatatagtc 28741 ggaacaaagg aaatgggaag gttaataatt tcaaaattaa aataagattt caaaataaga 28801 ttaatcaagg cgtggaaatt atagaaaatg cataatagtt gtatgatata aatgtaaagg 28861 gtctaaataa tattatttag accctttaca ttatacaagg atttcaatac ttagtatatt 28921 taccaacaag tttaccgatt attgtaactt cattcctgtt aaacacttct tttcccagaa 28981 gatcgctgtc agcctttaaa ataaccagat cgggattatc gtgatgagtg tagtatctta 29041 aaagtacgtg attttcatac aatatcataa cgatatcccc gtcttttaat tcataatttc 29101 tgcttattac aagaacgtct tcgtacttta ttccgctttc ggaaaggctg ttgtccggac 29161 aatcaattat aaagcagtcg ctgccttccg ggaacaggct ggaaggtaca ggaaggtagt 29221 taataatgtt gtagatgtta agcaagtcat tgacgtttct ctgacttact tttttaattt 29281 ttggcaaata tacatgggga gcatattggg agttggtgtt aacaagctgt atggaccttg 29341 ccatacccac ctctcttttg attactcctt tttgctccaa acggttaagt attccctgta 29401 cagcaccggg ggttttttca cctaccaatt ccccaatttc ccttacggta ggaggtatac 29461 ctttggattt gatgaaagac tcaataacca tgtatacctt tttttgtttt gcggttaaga 29521 aatcaaaatc tgaagacacg ttgaccatcc ttttacactt atttttttct tatatttttg 29581 taatttatgt ttttgatgcg ttgtaccacg tggcacccat ttttcttgtt atacccttcc 29641 aaataagaag ggaaacaaga aagtagttcg atttacataa aacattaaaa ttagtttagc 29701 aaatataaat caatatatca actttaatta atagaagtat agtaaataac aagaaaattg 29761 ctcgaatata tgttaacttt tcggcaaaaa agtttgctga catcaataaa tttccaatga 29821 aaaacaggta ttttttcaat aaaattacgt attatacctt taaaaatgct tggcaaaggt 29881 tttggatatg gagaaaaaga tatttaaact tctaaaaaat ggtacatgct atattccgga 29941 gtttattggg aaaaaagata ttttggtggt tcaaaataaa atttacaaaa ttgaaaacca 30001 tatagatgag tccgttgttc cggaccttga aattattgat tgcagcggaa aaatagtatg 30061 tcccggactc attgaccagc atatccatat tacaggaggt ggaggagaag aggggccggg 30121 cagcagaata cccgaaatta tgctgtccga gtgccttacg gccgggataa caacggctgt 30181 gggggtgttg ggagccgaca gtataaccag gaacatatcg gggcttttgg cgaaagcaag 30241 ggcgctggag gaagaagggc ttaacacata tatatatacc ggaagctaca ggattcctac 30301 ggccacgctt acaggaagcg tgatgtccga tatagccctg attgacaaga ttattggggt 30361 cggcgaaata gctgtttcgg accacaggtc ttcccaccct tcccttgaca tgctcaaggc 30421 tgtagccagt gaagccagga tggggggatt ggtcggaaaa aaggccggag tcgttcatat 30481 acatgtggga gacgggaaaa aagggcttga gccggttatt gaacttgtgg caaattctga 30541 ttttcccata gagatgtttg tacccaccca tttaaacaga aacagaactt tgttttttca 30601 ggcaatagaa tatgccaaaa tggggggaaa catagatttg acggccgggg agaccaatga 30661 gacagggtat gcggtgccgg atgccttaaa actccttgca gatgcagggg tggatatgga 30721 cagggtaact gtgtcatcgg atgccaacgg cagcattccg gcaaaagaag gatgcggtcc 30781 gggggttggc agggcggacg agcttattaa tgacataagg agcagtattt taagcggtaa 30841 attgactgtg gagcaggctt taaaaactgt caccgtgaat gtggcaaaag tacttaaact 30901 ttacccgaaa aaaggtgtta ttagaccggg aagtgatgcg gacatacttg tctttggaaa 30961 agaagacctg aagctggaca aggtgtttgt aaacggtgag cagtttgtga ataacggcaa 31021 ggtgcaaaaa tggggacggt atgaagaaaa atggcatgga taatgttaaa agaaagggat 31081 aatgaatatc agtgataaaa cgtgcaaata ctaacttggg tgatgttatg gaaagaataa 31141 attttcaaaa gacagggacc aggagcaata tcattttgct gacggtagga tggatttcgg 31201 ctttgctgtc cctggttata tatccgttta ttttcggagt ggtgggagtg ataacgggta 31261 tactggcaac caaaaacgga agcaaagccg gacttcctct gatagtgtca agtatcattc 31321 ttatgggcat agggctgata ttcagcggag taataatgaa ctatgccaga cgatatcttg 31381 gcatatagtc cgttgtgaaa gagcaagggc atattaaaaa gccttgcttt tttattgagg 31441 atatttgcaa ggtgatttct gccaaatatt catataaaaa tttggaggaa ataatgggtc 31501 agaaagtaag gggaaatttg attataattg gcggtgccga ggacaaggtc gggaaaaaaa 31561 ccatattaaa gtatgttgct gacatcgtca gagaaaagaa aggcagtttg gtgatattga 31621 ccacagcaac ccaaaagcct caggaggtcg gaaacaatta cagacaggtg tttgaaacgc 31681 tgggattaat ggatatagat gtgttgaata taaattcgcg cgatgaggcg gacttggacg 31741 agaatgccga aaggataaga agttccggag gtattttctt taccggaggg gatcagctca 31801 gaataacaag cattctcgga ggcacaaaag tatataaagc cctgcatgag gtctattcaa 31861 aaggtgttgt gattgttggg acaagtgcag gggcatccgt tatgagcaat acgatgatag 31921 tggaaggaaa ggacaatgag ccggcaagga aatgcaccat gaaaatggct ccgggattgg 31981 gatttcttga agaagccata attgaccagc attttgacca aaggggaaga ataggaagac 32041 ttctttgcgg tgtggcggaa aaccccttta tgctgggaat aggaatagac gaggatacag 32101 ccataagagt gtatcctgac gctcattttg aggtgctggg aagcaatgcc gttacagtga 32161 ttgacggcag cactataaaa agcaccaatg tgtctgagct caatcctgat gagatactgg 32221 caatctccgg agtaacgctg cacgttttgc cttgcggcta cggatttgac atgaaaaaaa 32281 gagaagtaat tcaacctact gacagaaaac tctaatcgct tgtttgtttg ggaggaagga 32341 aagtgcgaat acaaagtata caatgttttg caggaagaaa tatttacagt cacaagcctg 32401 tcgttaaggt gacattggat ataggagaat tgtacaaatt accaacaaag gaccttggag 32461 attttaatga aagacttctt gccttgtttc ccggattaaa aaacattatt gttctttggg 32521 atatgagggc ggatttgaag aacgtttgaa agaaggcaca tatataggcc atgtaacgga 32581 gcatttgatt atagagcttc agaatatatt gggatatgaa gttaattatg gcaaaacacg 32641 gattgttgag gaaccgtcac tgtactttat agtgtttgaa tataaaaacg aaaagtgcgc 32701 catagagtgt gcaagagcgg cggtaaacat tgttttaaag cttgtacgca atgaagaggt 32761 tgatacggaa gcaattataa ataatttaag ggctattgca gtggaaacgg atatgggacc 32821 cagtacaaaa gcgatctatg aagaggcaaa aaagagggga atacctgtaa cgagaatagg 32881 cgacggcagt gttctaaggc tgggatacgg caagtattcc cggattgttc aggcttcttt 32941 gacggatttt ccgagctgta tcaatgtcga tatggcagga aacaaacagc ttgcgaaacg 33001 cctcttggcg gaaaacaaaa tccctgttcc cgacggagat acggcctaca gttttgaagg 33061 tgctttgcag atagcacggg agataggttt tccggttgta ataaagccgg tggacagcaa 33121 tcagggaaaa ggagttactc ttaatattaa agatgagcag gaaatggaga ttgcatataa 33181 tgaagcccgg aaatattcaa gagtggtact ggtggagaaa tatgtaaagg gaaaagatta 33241 cagagttttg gtggttggtg acagggttgc ggcggttgcc gaaagaagac cgccttttgt 33301 aattggagat ggcgttcata cggtggagga gcttgtcgca attgaaaatt taagcagctt 33361 aaggggggac gaccatgaaa agccccttac aaaaatcaag ttggatgcca cagcattaaa 33421 ggttttgaaa gatcagggca ttggcaagga ccatgtacct tctttgggtg aaagaatata 33481 tctaagatac aatggaaact taagcacagg aggtaccgcg agggaatgta ctgatgagat 33541 acatccgtat aatgctgaca ttgcggtaaa ggctgcacaa attatagggc ttgatattgc 33601 aggtgtggat attaccactg aggatatatc ggtaccaatc agcgaaaatg gtggtgccat 33661 aattgaaata aatgccgcgc cgggacttag aatgcatttg tttccttcgg aagggaaaac 33721 cagaaatgtg gcggcggata tactggatat gttgtttccg gaagcatccc cccattcgat 33781 tcccattgta tctgttaccg gtactaacgg aaagacgacc accacgcgac tgatcgggca 33841 tactcttgcc tgcctgggga aaaaggtggg aatgacatcc accggaggca ttttcattgg 33901 cgatgaatgt gtcttaaaag gagacaacac cgggccgaca agtgcggcaa tggtattgtc 33961 atcaaaagaa gtggaagttg cggtacttga gactgcaaga ggcggaattg tgagaaaagg 34021 tctggggtat gaccttgccg atgtgggagt tataaccaat attgcggaag accaccttgg 34081 tattgacggg atgaatactc ttgaagattt ggcatttgcc aagtcattgg tggttgaggc 34141 ggtaaaacct ggcggatatt ctgtgttgaa tgcggatgac aagtttgtgc ggtattttat 34201 ggagagggca aaaggagaaa ttattctgtt ctcgaaaaat aacagcaatc ctgttgtgaa 34261 ggagcatatg caaaaaggcg gaaaagcgtt atatgtggac aaagacacaa ttttcatata 34321 caatggaaaa actgccgaag ttcttatgag tgtaaaagag attccaataa cctacggagg 34381 aatgattgaa tgcaatattg aaaattccct tgcagctgct tcggcgctgt atggcttgaa 34441 tctttccatt gaagccatac gaaaaggact ggcaaccttt aatcccgata tggaatccaa 34501 cccgggaagg tttaatatcg tggatatggg cgatttcaag gtgatgcttg attacgggca 34561 caatccggca ggataccttg aggttatgaa atttttggac aaaattgatg caaaaaggct 34621 tgtaggagtt ataggtatgc cgggcgacag ggatgactta agcatataca aggcaggaga 34681 aatatgcagc aaatgttttt ctaaaattta tataaaagag gatagtgatc ttaggggaag 34741 agagccggga gaagtggcgg gaattctcta cgatgccgtt atcagcagcg gaaccaaaaa 34801 agaaaatgtg gagataattt attctgagga cagagccctt gagaaagcac ttcttgacgc 34861 acagcccgga gattttgtgg ttatgtttta tgagaatttt gaaagggcgg cagaggtcgt 34921 ggaacgggtc cgcagagagc ttctggagaa tactgatacg gccggtccgg taattcagaa 34981 tgttggataa aaagttttgt cctttttcta tttatgaagt ataatgttat aaagaaaaat 35041 aacggtgtcg ttacaatgtt gaataagtga taacgaaatc gttggtaata ttcaataagt 35101 tgttagtgtt caataaattt attaaaatat tcaataaata gaaagaggta ttgctatgat 35161 agacaaagag cgtataaagg ctgctgtaag ggaactgctg atcggaattg gagaagaccc 35221 tgaccgtgag ggattgcttg agactcccga ccgggtggca aggatgtgtg aggaaatatt 35281 tgccggactt catcaggacc caaagtccgt tgtaaaggtg tttcaggagg aaaaccacga 35341 ggaaatggtg atggtgaaag atattcccat ttactcaatt tgtgagcatc acctgctgcc 35401 gtttatagga gtggcacatg tggtttatat tccaagaaaa ggcaaaatta tggggcttag 35461 caaacttgcc aggatagttg acattatcgc cagaaaaccg cagcttcagg aaaggcttgg 35521 cagtgaagtc gccaatgtca taatggagtc cataaatccc ttgggagttg cagtggtggt 35581 ggaggctgaa cacttgtgca tgacaatgag gggaataaag aaggcgggtt caaaaaccgt 35641 aacttcagca cttcggggta ttatcaagac cgatgcccgg accagggcgg aggttatggc 35701 tctcataaac ggaagatgag ccaggaggat ggttcctctt ggctcatttt cacaaaaccc 35761 gtctaaaacc actttatgat tgggaggatt taagacatgt ggttttttat aataatgggt 35821 gttttcctca ttgtgatggg gctgacaatt catgtgttta agtggtactt tttaatctcg 35881 ggttataaca ccatgcctga ggagaaaaaa gcgaatgtgg atgtaaaagg ccttggacgg 35941 ctgataggaa tatacttcta tgtcaacggc gctgtatcca ttgcagccgg tgtgttttat 36001 gctttggagc cgggaaaaat cctgatttcg gtcattgcct tttttatgct ttccacattt 36061 tatgtggtga ttagggctca aaagtacgac ggaaatcttt atgacgaaaa tggaaagctt 36121 agaaaaggtg cgtggaagca acttgtgatt cccggggcta tttgtgttgt aacgttaatc 36181 tttgttgccg ttgtgatgta tttttcatat cagccgacaa gagtaagttt tcttgaagaa 36241 ggtatacaaa tccatggtat gtacggggaa gtgtatactt gggaatccat tgaaaatgtc 36301 agtttgaagg aggaactgcc gaccattcaa atacgcacca atggttcggc tctgggttca 36361 aagttaaagg gacattttaa gacaaaagaa ttaggttcgg tcaaattgtt tgttaatact 36421 gaaaatcctc ccttcattta ccttgaaact aataacggca ttgttatttt taatatgaat 36481 gacagagacg aaactcagaa aattttcaat gagattttaa gaaaagtgga ataacaattc 36541 aggatatatt aagaagatat ataacggatg gaaaaaatct tagcatgcgt tttgtcaata 36601 ggtaaattga aaataataaa aaattgcaag atttaatttt gaattgttta cgcattatcc 36661 gtccgattgc agcatttttt tcaacttgct gcttttttta tgcataaaaa caaagtatct 36721 tattaacaag ttaaatgttt gattatgatg ttaatctatg ttatatttta aaaggtaact 36781 aaccggatat ttgatatact cgtattctgt ctaaacagaa aacaagtaaa aaatgtaact 36841 gataagtttt tttaactttt gtttgcgggg tgcgacagga tggtcttcaa aaaaatattt 36901 acgcttgaaa tcaaattgct tgcaaaaagg ttttatttga tgattccttt gtttctatgt 36961 tttctgtata tgttttacgg ctacactgta atgaaaaatg agcttgataa ttatatgttt 37021 ataagaacca gcggttttgt tatgatgttt atgacaattc tgtcaatgtg ttttggtgtt 37081 ataaatgcca gacaggagaa agatgccaaa tttgaggaag tgttaaatac attgccggct 37141 gcctggacac gccagataac aaaggttttt acgtggtcag tgtggtcttt tgtttattgt 37201 ttgatacttg ctgtattctg taccgtttgg gttgataatg gattaaacga attgggcaag 37261 tacgctttgc aagttgtacc ttacatattt gtgaattttt atatgcccat ggtatccacc 37321 tggcttattg cttattccgt ggaaaaaaca tttaatccaa agataggatg gcctgttttg 37381 ctgttaatat ggtatcttat ttccccgata aatgacagca gaagtaaagt tgctcttatg 37441 cttaatcaat ttgttgaaga cccctatgga gattcacgtc ttttacatta cgggcttgat 37501 acgactttgc aagcaccttc tcaatattga gttactgggt aagctgagaa gccgaagtct 37561 ctatccgccg gtaagaatca atcaggtccc atacaccggc acgatcatca acattgg //