LOCUS NZ_ACVX01000054 13924 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00027, whole genome shotgun sequence. ACCESSION NZ_ACVX01000054 NZ_ACVX00000000 VERSION NZ_ACVX01000054.1 GI:256005999 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000054. FEATURES Location/Qualifiers source 1..13924 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene 65..259 /locus_tag="ClothDRAFT_2800" CDS 65..259 /locus_tag="ClothDRAFT_2800" /inference="similar to AA sequence:KEGG:MXAN_6788" /note="KEGG: mxa:MXAN_6788 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430939.1" /db_xref="GI:256006000" /translation="MVIIWGIEYTSGLVLTNILGTAPWFYTGPFAVDNLVRLDYAPAW FVAGLIFERIHEALDIYKIA" gene 611..940 /locus_tag="ClothDRAFT_2801" CDS 611..940 /locus_tag="ClothDRAFT_2801" /inference="protein motif:TFAM:TIGR01068" /note="TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: sfu:Sfum_1708 thioredoxin" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="ZP_05430940.1" /db_xref="GI:256006001" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR006662" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /translation="MAGEKVVILTKENFEQEVLNSDKVVMVDFWAPWCGPCRAVSPII DELAEEYDGRAKVAKLNVDSEGEVTEKFRIMNIPTIMVFKNGEVVEKLIGARSKTELA SAIDKHL" misc_feature 644..928 /locus_tag="ClothDRAFT_2801" /note="TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947" /db_xref="CDD:48496" misc_feature order(710..712,719..721) /locus_tag="ClothDRAFT_2801" /note="catalytic residues; other site" /db_xref="CDD:48496" gene 1163..1729 /locus_tag="ClothDRAFT_2802" CDS 1163..1729 /locus_tag="ClothDRAFT_2802" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430941.1" /db_xref="GI:256006002" /translation="MAGEKRFGTALFGFKKTDVNSYIEKILREFDEKLKEKDNEITAL KNQCRELRIKYEDIARKAEQINMDRAKIADVLIKAQEKAEMILQEAKEKADEERRKLS ELTEQEKEKLVDMKREIKALKQEITKTLKKYELDLEKVVEFAGDIEGMENMNKDETKN DKSEDDDDEISDAILEEIMEEYAGKSNT" gene 2245..2724 /locus_tag="ClothDRAFT_2803" CDS 2245..2724 /locus_tag="ClothDRAFT_2803" /inference="protein motif:PFAM:PF01037" /note="PFAM: regulatory protein AsnC/Lrp family; SMART: regulatory protein AsnC/Lrp family; KEGG: vha:VIBHAR_07108 transcriptional regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, AsnC family" /protein_id="ZP_05430942.1" /db_xref="GI:256006003" /db_xref="InterPro:IPR000485" /translation="MEEILEILESNSKISPEEIAVMVNKSVEEVREAIKKYEEDNVIL GYMSLINWEKTSKESVTALIEVKVTPQRGEGFDKVAERIYRFPEVKACYLMSGGFDLT VIVEGKTMKEVALFVAEKLSTLESVLSTSTHFVLKKYKDKGTIFEKKQKDDREAVVL" misc_feature 2248..2670 /locus_tag="ClothDRAFT_2803" /note="Transcriptional regulators [Transcription]; Region: Lrp; COG1522" /db_xref="CDD:31711" misc_feature 2254..2559 /locus_tag="ClothDRAFT_2803" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:185792" gene 2721..3893 /locus_tag="ClothDRAFT_2804" CDS 2721..3893 /locus_tag="ClothDRAFT_2804" /inference="protein motif:PFAM:PF00155" /note="PFAM: aminotransferase class I and II; KEGG: pub:SAR11_0279 aspartate transaminase" /codon_start=1 /transl_table=11 /product="aminotransferase class I and II" /protein_id="ZP_05430943.1" /db_xref="GI:256006004" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /translation="MNIAEMVLPTVRQVPPSGIRKFFDLVNEMKDAISLSIGEPDFVT PWNIREAGIYSLEKGHTHYSPNAGFMELREEICKYQERKYNLKYDPKTQVIVTVGGSE GIDIALRALVGPGDEVIIPEPCFVAYKPCTIFTGATPVIVNLSAENEFRLTPELLEKA ITDRTKVLILPYPNNPTGAVMEKKDLEAIVEVLKDKDIIVISDEIYSELTYGVKHVSI ASFPEMKDKTVVINGFSKAYAMTGWRLGYCLGHPDLISQMYKIHQYAIMCSPTTAQYA AIEALRNSDDDVEAMVREYNRRRRIMVEGFRSAGLECFEPLGAFYVFPCIESTGMTSY EFSERLLMEEKVAVVPGTAFGECGEGYVRSCYASSMDNIIEAMKRIKRFVERNRKK" misc_feature 2811..3878 /locus_tag="ClothDRAFT_2804" /note="hypothetical protein; Provisional; Region: PRK08912" /db_xref="CDD:181580" misc_feature 2817..3866 /locus_tag="ClothDRAFT_2804" /note="Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609" /db_xref="CDD:99734" misc_feature order(3015..3023,3093..3095,3243..3245,3336..3338, 3417..3419,3423..3428,3450..3452) /locus_tag="ClothDRAFT_2804" /note="pyridoxal 5'-phosphate binding site; other site" /db_xref="CDD:99734" misc_feature order(3024..3026,3123..3125,3315..3317,3444..3452, 3537..3539,3546..3548) /locus_tag="ClothDRAFT_2804" /note="homodimer interface; other site" /db_xref="CDD:99734" misc_feature 3426..3428 /locus_tag="ClothDRAFT_2804" /note="catalytic residue; other site" /db_xref="CDD:99734" gene complement(4139..4279) /locus_tag="ClothDRAFT_2805" CDS complement(4139..4279) /locus_tag="ClothDRAFT_2805" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430944.1" /db_xref="GI:256006005" /translation="MDKIEYLRQKLHKVIESGDHNAILTVSQELDVLIVRHMINQLHL SK" gene 4624..5319 /locus_tag="ClothDRAFT_2806" CDS 4624..5319 /locus_tag="ClothDRAFT_2806" /inference="protein motif:PFAM:PF01381" /note="PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: rpa:RPA4129 XRE family transcriptional regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, XRE family" /protein_id="ZP_05430945.1" /db_xref="GI:256006006" /db_xref="InterPro:IPR001387" /translation="MAFAAMLKQLREEKRLSQKDIADYLGITRQAVASYELAKREPDY EVLKKLADYFDVSIDYLLGRTNCRDATAAIIGKNIDLIRGNLTYKELSEDISAKLGAL IFPEMLELYARGERMPFVGTIKILAKYAQVRDSFFYTHNTPETYEREKELYRLEMSQQ KMAEEIEETKGLLDFTGDVELKKWILKESSLPYIKLAKEIQDAGLPVEVFKPLINSIK NSNSKEDNKSMEE" misc_feature 4633..4806 /locus_tag="ClothDRAFT_2806" /note="Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093" /db_xref="CDD:28977" misc_feature order(4645..4647,4657..4659,4732..4734) /locus_tag="ClothDRAFT_2806" /note="non-specific DNA binding site; other site" /db_xref="CDD:28977" misc_feature order(4654..4656,4729..4731) /locus_tag="ClothDRAFT_2806" /note="salt bridge; other site" /db_xref="CDD:28977" misc_feature order(4675..4680,4711..4713,4720..4722,4732..4737) /locus_tag="ClothDRAFT_2806" /note="sequence-specific DNA binding site; other site" /db_xref="CDD:28977" gene 5627..6700 /locus_tag="ClothDRAFT_2807" CDS 5627..6700 /locus_tag="ClothDRAFT_2807" /inference="protein motif:TFAM:TIGR00020" /note="TIGRFAM: peptide chain release factor 2; PFAM: Class I peptide chain release factor; PCRF domain protein; KEGG: gme:Gmet_2366 peptide chain release factor 2" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="ZP_05430946.1" /db_xref="GI:256006007" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /translation="MKWGNLFDIASIGNQIEELEQKASEPDFWNDTENSQKILQKIKS LRSKVERYNKLVSQWEDLITLCELGIEEQDESVIPEAVEGFKAFKKEFEALRLETLLT GQYDKNNAILTLHAGAGGTEAQDWVQMLFRMYTRWAEKKGFTVKVLDYLDGEEAGIKS VTFQVIGENAYGFLKSEKGVHRLVRISPFDASGRRHTSFASLDVMPELNDDIEVHINP DDLRIDTYRSSGAGGQHINKTESAVRITHIPTGIVVSCQSERSQFQNKDTAMKMLKAK LMELKERENKEKIEDLKGIQLEIAWGSQIRSYVFCPYTLVKDHRTNYEEINVDAVMDG ELDGFINSYLSSVSKDNNKEKVG" misc_feature 5645..6658 /locus_tag="ClothDRAFT_2807" /note="peptide chain release factor 2; Validated; Region: prfB; PRK00578" /db_xref="CDD:179072" misc_feature 5825..6157 /locus_tag="ClothDRAFT_2807" /note="RF-1 domain; Region: RF-1; cl02875" /db_xref="CDD:186537" misc_feature 6245..6586 /locus_tag="ClothDRAFT_2807" /note="RF-1 domain; Region: RF-1; cl02875" /db_xref="CDD:186537" gene complement(6810..9587) /locus_tag="ClothDRAFT_2808" CDS complement(6810..9587) /locus_tag="ClothDRAFT_2808" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: conserved hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430947.1" /db_xref="GI:256006008" /translation="MKKILLLFIILISIVMLSFSVTFAGTNLNLYYNGKIHALKSTVV NKNDKYYLEADEMAQILGVKLKGDLSNQILTIDDGKTTSTYSARPLDYSIAAVKNYNP NIPQIINQKFYLPFEFIEEKFNLTVKYDEESGSIYFLENENLKTFKNITHGYLLNIPS QISIDLSGSHNAFNDNSVVLVDNNGEFSYTITCDKLDATSIAGMRLILNDFTSPDEEI FNAISDYAKSYFRAMQALYKNEFLFGGTDAALSESNMKIFADYTDILYGQPSDVVLYN TIKSDRLFSIEETHIMITVPIYSKMSIYTINIAGKRGFLTSENIVKINELVNALKIPD LPNNKNSLKILNDKKTVKDANLGIYPALSGGNIEYIEYQNPQQNYKIQYPSSFVPYLQ NSIIESLDYTSFKIDYNNYVSISVETIQDDPDTCIKNKLNFIKSSPSVKTDSVEEGKT SLSGKTFHYIKYETKDVSDSYFIQDYYTIYNSRLYKIELNSKLIKPSEAIANEFLKIV KSIEFTKPEANNFSTETGFKKFLNEYEGYSFSYPESWELKNTSTDINFDRFSIVCPEY SGPLDICINESEFLIDASAGELLRLFGGNNAELLTNYAANYYAPYGTKNTKILNTSAK IENDIIYIYRLINFLGEGQRHKLGYSVDIIRDGKIYSLFLSVSDYLCTDGSLADKELS KAINTIVNSFTLEETEEYLKRKSAGETRNQKVVFLENCFKLILGRSTTLTHAKTLNSN DDILIQLSNCKEAGTYRLKFDYENKNFEIISVILQKDAVKSSEPKLKEMYGSKLIHRI TPDYDNMTVTIRYSDGIDMPVLEKSYFIDVLPSEDGFDIFLARNYTYSELKSKCTSYL ENYLLTNVEVQFPKEYNQPVKYSSKGRYEAHFINVFARYSNKSGYFLLKIDPMADSVS AIGFVPTDETK" sig_peptide complement(9513..9587) /locus_tag="ClothDRAFT_2808" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.988 at residue 25" gene 9898..10767 /locus_tag="ClothDRAFT_2809" CDS 9898..10767 /locus_tag="ClothDRAFT_2809" /inference="protein motif:PFAM:PF03807" /note="PFAM: NADP oxidoreductase coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: sat:SYN_02774 putative cytoplasmic protein" /codon_start=1 /transl_table=11 /product="NADP oxidoreductase coenzyme F420-dependent" /protein_id="ZP_05430948.1" /db_xref="GI:256006009" /db_xref="InterPro:IPR004455" /db_xref="InterPro:IPR011128" /translation="MNIGIIGAGKVGCALAEGLKNNGFNISGVYSRSVGSQKYLCEKL GKIFENDLEDAVKNSDLIFISVSDNNIIEVAEEIVRKVDNDALRSKTFIHMSGALTAK ALKPLENLGAYTGSLHPIQSVADKDSGWKKLYNIYYGFEGCEEALKHALTVVKSFEGK LIKIKEQDKTLYHAAACIISNYTVTLSYVAYKILESIGFDRETADKAFLPLIKNTVHN IERLGSIDALTGPVSRGDNSVVEQHVKSLRALDKELEKMYKVIGRMTVEVAQKKGTLN DDAFQKLMKILEL" misc_feature 9898..10746 /locus_tag="ClothDRAFT_2809" /note="Uncharacterized conserved protein [Function unknown]; Region: COG5495" /db_xref="CDD:35054" misc_feature 9901..10185 /locus_tag="ClothDRAFT_2809" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature 10300..10695 /locus_tag="ClothDRAFT_2809" /note="Domain of unknown function (DUF2520); Region: DUF2520; pfam10728" /db_xref="CDD:151214" gene 10795..11541 /locus_tag="ClothDRAFT_2810" CDS 10795..11541 /locus_tag="ClothDRAFT_2810" /inference="protein motif:PFAM:PF00731" /note="PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: wsu:WS0137 NCAIR mutase (PurE)-related protein" /codon_start=1 /transl_table=11 /product="1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase" /protein_id="ZP_05430949.1" /db_xref="GI:256006010" /db_xref="InterPro:IPR000031" /translation="MEIEYLRKILESVRDGNIGIDEALTKLKNLPFEDLGFAKVDEHR NIRNGYPEVIYCQGKTVEQVKKIVEKLMEKNNNIMATRADIKCFEAIREITDDAVYYE QARIVVVKKRDIPKVDKMIAVVTAGTADIPVAEEAAVTCEIMGNSVERVYDVGVAGIH RLFARLDVIRAANVLIVVAGMEGALASVVSGLVDKPVIAVPTSVGYGANFGGLSALLT MLNSCAAGIGVVNIDNGFGAGFLASMINKL" misc_feature 10804..11538 /locus_tag="ClothDRAFT_2810" /note="AIR carboxylase; Region: AIRC; cl00310" /db_xref="CDD:153673" gene 11556..12779 /locus_tag="ClothDRAFT_2811" CDS 11556..12779 /locus_tag="ClothDRAFT_2811" /inference="protein motif:PFAM:PF01969" /note="PFAM: protein of unknown function DUF111; KEGG: geo:Geob_1111 protein of unknown function DUF111" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF111" /protein_id="ZP_05430950.1" /db_xref="GI:256006011" /db_xref="InterPro:IPR002822" /translation="MRILYFDCFAGASGDMILGALLDLGIDVGIFKRELAGLNLDGFD IAVEKKVINSIAVTDVNVIVKEECNHHTGHHHHCERNLADIEKIIDESSLKDNVKRLS KKIFSEIARAEAKVHNKSIEDVHFHEVGAIDSIVDIVGTAICLDLLKVDKIYSSPMHD GTGFIECQHGKLPVPVPAVLEMLKESNIPYITEDVNTELLTPTGLGIIKCVASKFGPM PPMTIEKVGYGAGKRQTGRFNALRCILGNAKEKEKIDDEICMLETNIDDMNPEILGYV MNRLFENGALDVFYTPVYMKKNRPGVLLTVLTDKEHEEKLVDIILTETTTLGIRKTTA QRYVLEREIKHVNTEFGKIRVKESSFGDYKKYSPEFEDCKKVAQELKIPLSKVYDAVN KAILVFEERNENALQ" misc_feature 11556..12755 /locus_tag="ClothDRAFT_2811" /note="Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398" /db_xref="CDD:186571" misc_feature 11565..12722 /locus_tag="ClothDRAFT_2811" /note="Protein of unknown function DUF111; Region: DUF111; pfam01969" /db_xref="CDD:145249" gene 12766..13707 /locus_tag="ClothDRAFT_2812" CDS 12766..13707 /locus_tag="ClothDRAFT_2812" /inference="protein motif:TFAM:TIGR01212" /note="KEGG: gme:Gmet_3163 hypothetical protein; TIGRFAM: conserved hypothetical protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430951.1" /db_xref="GI:256006012" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /translation="MLYNKFSTYLKQKYGTKVYKLPLNLPVTCPNRDGRISSKGCIFC GEEGAGFENLPNFLGIKEQLKLNSRYIGKNYGSEKFIAYFQNYTNTYLPLEDFKRHIN DALEENIVAVYISTRPDCVRDSYLSFLKEIKLSKGVDIVIELGLQTVNYHTLKLLNRG HLLAEFIDAVLAIKRYGLESCAHYILDIPMDSMDDVIEGARILSALGVNQVKCHSLYI LKDTVLGEMYKRGEIKHVTLEEYIERAISFLEYLDPSIVIQRLIGRAPEERSLFCNWG MSWWKIHDSIERKMTEENRYQGKKFDYLNGRALDGMD" misc_feature 12766..13680 /locus_tag="ClothDRAFT_2812" /note="Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242" /db_xref="CDD:31435" misc_feature 12883..13359 /locus_tag="ClothDRAFT_2812" /note="Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056" /db_xref="CDD:187212" ORIGIN 1 ttttctggaa cctatacacg atattataaa acaatggagg tggcaaatca gaggtcttat 61 ctgggtggta attatttggg gaatagagta cacaagcgga cttgtactga ccaatatcct 121 gggaaccgct ccctggttct acaccggacc gtttgcagtg gacaatcttg tgaggctgga 181 ttatgcacct gcgtggtttg ttgcaggact gatatttgag agaattcatg aggctcttga 241 tatttataag attgcataat tattgcataa ttaaattatt gcatgaataa aaaattgcgt 301 gactgaataa gcagatgaaa tgcgcttaaa aatccggtgc cttgacaatt gggtatcgga 361 tttttgagta tttttttatt gagaaatatg catattatgg atataattta tttatacaga 421 aatctaaaaa ttttatcgat tggtgttttg attttttgat tgctgggtaa gaatagaata 481 agacgtttat aaacattatt gatgatataa actatataat gttggaggta aaaaggcaaa 541 attgatatat atttaaattg tgaaatatgt acaaacaata atgaaaaact tacgattagg 601 aggaaaaata atggcaggag aaaaagttgt aattttgaca aaagaaaatt tcgaacagga 661 agtattaaat tcagacaaag tagttatggt tgatttctgg gctccgtggt gtggcccctg 721 cagagcggta agtcctataa ttgatgagct tgctgaagaa tatgacggca gggcaaaagt 781 ggcaaagctt aatgttgaca gtgaaggtga agttactgaa aagttcagaa tcatgaacat 841 tcccacgata atggtgttta aaaacggaga agtggtggaa aagcttatag gtgcaagatc 901 aaaaacggaa ctggcaagtg ctatcgacaa gcatttgtaa ttgataaaaa tatataattg 961 tttgtaaaca tccgtagttt cgggtgcatg ctttctatca gccatacatt atttaaaatg 1021 tatggttttt gctttttgaa ttaataattt tttctaaata aaagaaggaa ttttagaaaa 1081 aagattgaat atataaagga aggagtattg tgtaattttt attataaaaa tttctattat 1141 ttgtaattag gaggaaccac agatggcagg cgaaaaaaga ttcggaactg cattatttgg 1201 gtttaagaaa actgatgtaa attcatatat tgaaaagatt ttaagggaat ttgatgagaa 1261 actgaaggaa aaggacaatg aaataaccgc tttgaaaaat cagtgcagag aattgagaat 1321 taaatatgaa gatattgcaa ggaaagccga gcaaatcaat atggacaggg caaaaattgc 1381 cgatgttctt ataaaggctc aggaaaaagc tgagatgata ttgcaggaag ctaaagagaa 1441 ggctgatgaa gaaagaagaa aactttctga acttaccgag caggaaaagg aaaaacttgt 1501 ggatatgaag cgcgagataa aagcgttgaa gcaggagatt accaagacat taaagaaata 1561 cgagcttgac cttgagaaag ttgtggagtt tgccggggac atagaaggca tggagaacat 1621 gaacaaagac gagacaaaaa atgacaagtc cgaagacgac gatgatgaga tatctgatgc 1681 tattcttgag gaaatcatgg aagagtatgc cggcaaatcc aacacttaaa ttttaaggcg 1741 atatttgatg aatgtttcat ttgttgtaaa aattattact tgacagtgga aaaaaatata 1801 gtataattta aaataatttc atgaattgtt tactgcgatg acggggaaga gtacatttag 1861 atactttatc agagagtcgg gaaaatggtg gaagcccggc aaagtgtcta tatggaaggc 1921 agcccttgag cttctccttg agaaattgag tttcctaaat atttgtttgg gaaactcaaa 1981 agtagaggaa gacgtatcct cacgttacag aggagcagta tttataacag tatggatgat 2041 tgacagactg ttataagaac tggcagagtg agtacctgta cggtactaat tagggtggta 2101 acgcggaatg ctccttcgtc ccttgctttt aggatgaagg agtttttatt atatgttttt 2161 tatatatttt tatactgttt ttatactata tttatactat acatatttta acataataat 2221 ttttgattaa aggagtggat atatgtggaa gagattttag agatattgga aagcaacagt 2281 aaaatcagtc cggaagaaat agccgtaatg gtcaataaga gtgttgaaga agtaagagaa 2341 gctattaaaa agtatgaaga ggataatgtt attttaggct atatgagcct gataaactgg 2401 gagaaaacaa gtaaagaatc tgtaaccgct ttgatagaag taaaagttac acctcaaagg 2461 ggagaaggat ttgacaaggt tgcagaaagg atatacagat ttccggaagt caaggcttgc 2521 tatcttatgt ccggtggttt tgacctgaca gttattgttg aaggtaaaac catgaaagag 2581 gttgcgttgt ttgttgctga aaaattatcc acgttggaat cggttttaag tacctctacg 2641 cattttgtat tgaaaaagta taaggataag ggaactattt ttgaaaagaa acaaaaagat 2701 gacagggagg cagttgtgct atgaatattg cagaaatggt tttgccgact gtcagacagg 2761 tacctccttc agggatcagg aagttttttg atttggtaaa tgaaatgaag gatgccatat 2821 ccttaagtat tggtgagcct gattttgtaa ctccgtggaa tatccgggag gccggtattt 2881 attcgctgga aaaagggcat acccactatt cgccaaatgc gggatttatg gagctgcgtg 2941 aagagatatg caagtatcag gagagaaaat acaatttaaa atatgatcca aagacccagg 3001 ttattgtaac cgtaggagga agtgagggaa ttgacatagc tttaagggct cttgtcggac 3061 ccggagatga agtgattatt cctgaacctt gttttgttgc ctataaacca tgcacaattt 3121 tcaccggagc tactcctgtg atagtaaatt tgagcgcgga aaacgagttt cggctgacac 3181 cggaactttt ggaaaaggca attaccgaca gaactaaagt gttgattttg ccttatccca 3241 acaatcctac aggcgccgtt atggaaaaaa aggatttaga ggctattgtt gaagtactta 3301 aggacaaaga cataattgtt atttccgatg agatttattc tgagcttact tacggagtta 3361 agcatgtatc catagcgtct tttcctgaga tgaaggataa gacggtggtt ataaacggct 3421 tttccaaagc ctatgccatg acgggctgga gacttggata ttgcttgggg catcctgatt 3481 tgatttcaca gatgtacaag atacatcaat atgccataat gtgttctccg acaactgccc 3541 aatatgcagc catagaagct ttaagaaaca gtgatgatga tgtggaagca atggtcagag 3601 agtacaaccg aagaagaaga attatggttg aaggtttcag gagtgcaggg cttgaatgtt 3661 ttgagccgtt gggtgctttt tatgtttttc cgtgcataga atcaacagga atgacttcgt 3721 atgagttttc cgaaaggctt ttaatggagg aaaaagttgc ggtagttccg gggactgctt 3781 ttggagaatg tggagaagga tatgtacgtt cgtgctatgc cagctccatg gacaatataa 3841 ttgaagcaat gaaaagaatt aaaagatttg tcgaaagaaa tagaaagaag taaaaaatag 3901 aaataaaaag actctggttt tggaaagctt gagaagcttt tggcttctca ggcttttttg 3961 aataaaaaaa tgtactatgt ataaaacata gtacaaaaaa acagaaattc tatatattaa 4021 agttgtgcag gatgacaaat ttaaataaaa ctgaacttaa gcaaaatgcg acttaagcat 4081 tttgtaaatg cttgtaccat gtaaaaacat agaattctta taaaatacac agaataaatt 4141 atttacttaa atgtaattga ttgatcatat gcctcacaat taatacgtca agttcctggc 4201 tgactgtgag aatagcatta tgatcgcctg attcaattac cttgtgaagc ttttgtctca 4261 aatattcaat cttgtccaaa gcatccccct ccaagcaatc ttaattataa tatttattta 4321 taataatgaa tattttatct tcgcaaccgt aaattgattt aaataactgt atttaatgaa 4381 tttttaatga ataataaagt ttgccgtaaa acttgtttat tgtccataat ctatgataaa 4441 atgtttttag taaatcttca caaaaaagtc ctctttttta gtcgtatctt tatttataca 4501 tactttattt tacagcaaca ttttgttgct gtcaataaaa aatcaacaat ttgttaacat 4561 tttgttgctt tgtttttatg gttgtgcgaa aatagtgtca aatagtctcg aggtgatatg 4621 ggaatggctt ttgcagcaat gcttaaacaa ctcagggaag aaaagcgtct ttcacagaag 4681 gatattgctg attatttggg cattactcga caggcagtgg cgtcgtatga gcttgctaaa 4741 agggaaccgg actatgaagt tcttaaaaag ctcgcagatt attttgacgt atccattgac 4801 tatttgcttg gaagaaccaa ttgcagagat gctacggcag caattatagg taagaatatt 4861 gatcttataa ggggaaatct tacatacaag gaattgtcag aggatattag tgccaaattg 4921 ggagcgttga tttttcctga gatgcttgag ttatatgctc gtggtgaaag aatgcccttt 4981 gtcggaacga taaaaatact tgccaaatat gcacaggtaa gggattcttt tttttacacc 5041 cataacactc cagagaccta tgaaagagag aaagaattgt acagactgga aatgagccag 5101 cagaaaatgg cagaggagat tgaagagaca aaaggtttgc ttgattttac cggtgatgtg 5161 gaactaaaga aatggatttt aaaagagagc agtctgcctt atatcaagtt ggcgaaggaa 5221 attcaggatg caggccttcc tgtggaagtt tttaaacctc tcataaattc aattaaaaat 5281 agcaattcaa aagaagataa caagtcaatg gaagaataat tgtgatataa ttgtaattct 5341 tttatttcat ttcggataat ttatatcagg gtgcaaaatt ttataattta atagtttgga 5401 ccaattcacg ccggttgcat tatggtctta aaggctaaat actaccttac agagattatt 5461 ggaatttagt tgccaaatat tttaattaaa ttttatgata gacattattt cttatatgtt 5521 gtaaaataaa ccgtaatgaa atttaaatat tgattggagg agttgatgta agtgctggag 5581 cttgaacagc ttaaacttga aatcgatgat tttaagcaaa atttagatga aatggggaaa 5641 tctctttgac atcgccagta taggcaatca aattgaggaa cttgaacaaa aagcttcaga 5701 acctgatttc tggaatgata ccgagaattc tcagaaaatt ttgcaaaaga ttaaatcttt 5761 aagaagcaaa gtggaaagat acaacaagct ggtttcccag tgggaagatt tgatcacttt 5821 gtgtgagctt ggaattgaag agcaggatga aagtgtgatt cctgaggcgg tggaaggttt 5881 taaggccttt aaaaaggaat ttgaagcttt aagacttgag acacttctta ccggacaata 5941 tgacaaaaac aatgccatcc tgaccttgca tgccggggcg ggaggaactg aggcccaaga 6001 ctgggtgcag atgcttttca gaatgtatac ccggtgggcg gagaagaagg gatttactgt 6061 aaaggtactg gattatcttg acggagagga agcaggtatt aaaagtgtta ctttccaggt 6121 tatcggagag aatgcttacg gttttttaaa atccgaaaag ggagtacacc ggcttgtcag 6181 aatttctccc tttgatgctt cgggaagaag gcatacttcc tttgcttcac tggatgttat 6241 gccggagctg aatgatgata ttgaagtaca cataaacccg gatgaccttc gcattgacac 6301 ttaccgttcc agcggtgccg ggggtcagca tataaataaa accgaatcgg ccgtaagaat 6361 tacccatata cccacgggta tagtggtttc atgtcagagc gaacgctctc agttccagaa 6421 caaagatact gccatgaaaa tgcttaaggc aaagcttatg gagctgaaag agcgcgaaaa 6481 caaggaaaag atagaggact tgaaaggtat acagttggaa atagcatggg gaagccaaat 6541 aaggtcctat gtgttttgcc cgtataccct tgtgaaagac cacagaacca attatgaaga 6601 aataaatgtg gatgccgtta tggacgggga attggatgga tttataaatt cttatctttc 6661 aagtgtgtcg aaagacaaca ataaagaaaa agtaggataa tgtagtatag tagtatataa 6721 taaggtataa taaggaaaaa agcggtttaa ttatgacaaa agtctgcggc tttaaagctg 6781 cagacttttg aatttggctc ttattaagtt tatttggttt catccgtggg aacaaagcct 6841 atggcactta cactgtctgc cataggatca atctttagca aaaagtatcc tgatttatta 6901 ctgtatcttg caaacacgtt gataaaatga gcttcatatc tgcctttgct tgaatatttt 6961 accggttgat tatattcttt tggaaattgt acttccacat tggtcagtag gtagttttcg 7021 agataggaag tacacttgct tttaagctct gaataagtgt agtttcttgc aaggaagatg 7081 tcaaatccgt cttcggacgg cagtacgtcg ataaaatagc ttttttccaa aacaggcata 7141 tcaattccgt cggaataccg gattgttact gtcatgttgt cataatcagg ggtaatacgg 7201 tgaatcaatt tgctgccata catttcttta agttttggtt ctgaagattt tacagcatcc 7261 ttttgaagga tgacacttat aatttcgaaa tttttatttt cataatcaaa ctttaacctg 7321 taagttcccg cttctttaca gttgcttaac tgaataagaa tatcatcgtt tgaattcagt 7381 gtctttgcat gggtgagggt tgttgacctt ccaagaatta acttgaagca gttttccagg 7441 aaaactactt tctgatttcg agtctcaccg gcggattttc ttttcagata ttcctctgtt 7501 tcttccaaag taaaggagtt cactatggta tttatggctt tggaaagttc cttgtctgca 7561 aggcttccgt cggtgcataa ataatcactg acagacaaaa acagggagta aattttgccg 7621 tctcttatta tgtcgacaga ataaccgagt ttgtgccttt gaccttcgcc caggaaattt 7681 atcaatctgt agatatagat tatgtcattt tcaatttttg cactggtgtt taatatcttt 7741 gtgtttttgg tgccgtaagg tgcataataa ttcgcggcat aatttgtaag aagttctgca 7801 ttgtttccgc caaaaagtct taacagttct ccggcagagg catcaatcaa aaattcggat 7861 tcattgatgc aaatgtcaag aggaccggag tattcaggac atactatgga aaacctgtcg 7921 aaattgatgt ccgtggacgt atttttcagc tcccaggact cgggatagga aaaagaatat 7981 ccttcgtact catttaaaaa ttttttaaag ccggtttctg tggagaaatt gtttgcttca 8041 ggctttgtaa actctattga tttcacaatt ttcaaaaatt cattggctat ggcttcggaa 8101 ggttttatta atttgctgtt gagttcaatt ttataaagtc tcgaattgta tattgtataa 8161 taatcctgaa taaagtacga atctgaaacg tcttttgttt catattttat gtagtggaaa 8221 gttttgcccg acagcgaagt ctttccttcc tcgacagaat cggtttttac cgaaggagaa 8281 gattttataa agttcaattt gttttttatg cacgtatccg gatcgtcttg tattgtttcc 8341 actgagattg atacataatt attgtaatca atcttaaagc ttgtatagtc aagactttct 8401 ataatgctgt tttgcaagta tggaacaaac gaggacggat attgaatttt atagttttgc 8461 tgcgggttct ggtattcgat gtattcaatg ttacctccgg aaagagcagg atagattcca 8521 aggttggcat ctttaacggt tttcttgtca ttgagtattt taagagagtt tttattattg 8581 ggtaagtccg gtattttgag agcgttgaca agttcattga ttttaactat gttttcagaa 8641 gttaaaaaac ctctttttcc ggctatatta atcgtatata ttgacatttt agaatatatc 8701 ggaacagtta tcataatatg ggtttcttcg attgaaaaga gcctgtcact ttttattgtg 8761 ttgtacagca ccacatcgga aggctgaccg tataaaatgt cagtgtagtc ggcaaagatt 8821 ttcatgttgg attcgcttaa cgccgcgtcg gtgccgccaa acagaaattc atttttgtaa 8881 agggcctgca tggctctgaa atagcttttt gcataatcgc ttattgcatt gaaaatttct 8941 tcgtcgggcg atgtaaagtc gttgagaatc agacgcatgc cggcgatgga ggttgcatcc 9001 agtttgtcgc aggttattgt gtaactgaat tctccgttgt tgtcaacaag taccaccgaa 9061 ttatcattaa aagcgttatg agaaccggaa aggtcaatgc tgatttggga aggaatgttt 9121 aaaagatatc cgtgggtaat gtttttaaag gttttgagat tttcgttttc aagaaaatat 9181 atggaccctg attcttcgtc atattttacg gtcagattaa acttttcctc tataaactca 9241 aagggtagat agaatttttg atttattatc tgcggtatgt tgggattgta atttttgacg 9301 gcggctatgg aatagtccaa aggtcttgca gagtacgtac ttgttgtttt tccgtcatca 9361 atggtaagga tttggtttga aaggtcgccc ttaagtttga cgcccagtat ttgagccatt 9421 tcatcagctt cgagatagta cttgtcgttt ttgtttacga cagtactttt taaagcatga 9481 attttcccgt tgtagtataa gttcaagtta gtgccggcaa aagtaacaga aaaacttaac 9541 ataactattg atattaaaat tataaacaat aacagaatct ttttcatatg taacactatc 9601 ctcttacctc tttaattttt tgcatatttt atattaacca tggaacaagg ctatacgccc 9661 cctacattat gtataatatc aaaactaaac gtcacgtaca acgattgtta actctttgta 9721 aaataagtga aacaaacact taaaaaaata aatagaataa tataactcat gcactattaa 9781 taaaatttag aaattgtggt attattcaat tgattggttt cccaaaaaga agcctgcaaa 9841 aaaacgaatt tgcatgaata aaagagtgcg tgtgaatgac gggaaggtga tgccggtatg 9901 aatataggga ttatcggagc aggaaaggta ggctgtgcct tggccgaagg acttaaaaac 9961 aacggattta acatatccgg agtttacagc cgaagtgtcg gttctcaaaa atatctttgc 10021 gaaaaacttg gcaaaatctt tgaaaacgac cttgaggatg cggtaaaaaa ctccgacttg 10081 atatttattt cggtgtctga taataatata atagaggttg cggaagaaat tgttcgaaaa 10141 gttgataacg atgctcttcg ttcaaaaact tttattcata tgagcggagc gctcacagca 10201 aaagccttaa agcctcttga aaaccttgga gcgtacaccg gctctcttca tcccattcag 10261 tccgtagcgg acaaagacag cggatggaag aagctgtaca atatatatta tggttttgaa 10321 ggctgtgaag aagcattaaa gcatgcttta accgttgtaa aatcttttga gggcaaactg 10381 ataaaaataa aggaacagga caaaacgctg tatcacgccg cagcatgtat tatatccaac 10441 tatacggtga ccctttccta tgttgcttat aaaatattgg aaagtatagg gtttgacagg 10501 gaaactgctg acaaagcgtt tcttccgctg attaaaaaca ccgttcataa tatcgaaagg 10561 ctcggaagca tagatgcact taccggtccg gtgtcgagag gagataacag tgttgttgag 10621 cagcatgtaa aatctttgag ggcgctggac aaagaacttg aaaagatgta taaagtaatt 10681 ggaagaatga ccgttgaggt cgctcaaaaa aaaggtacac tgaatgatga tgcgtttcaa 10741 aagcttatga aaattttaga gctgtaaaat cctatacata tggagatgta ttctatggaa 10801 attgaatatc ttagaaaaat attggaaagt gtcagggatg gaaacattgg aattgatgag 10861 gctctaacaa agcttaaaaa tcttcctttt gaggatttgg gttttgcaaa agttgatgag 10921 cacagaaata ttcgtaacgg ataccctgag gtgatttatt gtcagggaaa aactgtggag 10981 caggtcaaaa agatagttga aaaactgatg gagaaaaata acaacataat ggccacacgg 11041 gccgacatca agtgctttga agccatcagg gaaattaccg acgatgctgt atactacgaa 11101 caggcaagaa ttgtggttgt aaagaaaagg gatattccga aagttgacaa gatgattgca 11161 gtcgtaacgg caggaacggc ggatatcccg gtagccgagg aggctgcggt tacatgtgaa 11221 ataatgggaa acagtgttga gcgggtttat gatgtcggtg tggcaggcat tcacaggctt 11281 tttgcacggt tggacgtaat ccgcgccgca aatgtactta tagtggtggc gggaatggag 11341 ggagccctgg caagtgtggt cagcggcctt gtggacaaac ccgtgatagc tgttcccacc 11401 agtgtggggt atggtgctaa tttcggagga ctttccgctc ttttgacaat gctgaacagc 11461 tgtgcggccg gaatcggtgt ggtaaatatc gataacggct ttggggcggg atttttggca 11521 agtatgataa ataaacttta gggaaggaaa aggatatgag aatactgtat tttgactgtt 11581 ttgcgggtgc cagcggtgat atgattctgg gtgccctgct ggatttggga attgatgtcg 11641 gaatttttaa aagggagctt gcaggattaa atttggacgg ttttgatatt gctgttgaaa 11701 aaaaagtaat aaactcaata gccgtaaccg atgtgaatgt tattgtaaaa gaggaatgta 11761 atcatcatac cggacaccat catcattgtg agcgcaattt ggcggatatt gagaaaataa 11821 ttgacgaaag cagcctgaaa gacaatgtaa aaaggcttag caaaaagata ttttcagaaa 11881 ttgcccgggc tgaggcaaag gtccacaaca aatccattga agatgtgcac tttcatgaag 11941 tcggtgccat tgattccatt gttgatattg taggtactgc aatttgtctg gaccttttga 12001 aagttgacaa aatatactcg tcaccgatgc atgacggcac gggctttata gagtgtcagc 12061 acggaaaact gccggtcccg gttcctgcgg ttttggaaat gcttaaggaa agcaatatac 12121 cttacataac cgaggatgtg aacacggaat tgttaactcc gacgggcctc ggaattataa 12181 aatgtgtggc ttcaaagttt ggccccatgc ccccgatgac tattgaaaaa gtcggatatg 12241 gggcaggcaa aagacagacg gggcgtttta atgccttaag gtgtattttg ggaaatgcta 12301 aagaaaaaga aaaaattgat gatgaaattt gtatgcttga gacaaatatt gacgatatga 12361 atccggagat tcttggctat gttatgaaca ggctttttga gaacggtgca ctggatgtat 12421 tctatacgcc cgtttacatg aaaaagaaca gaccgggagt tttattgacg gtgcttacgg 12481 acaaggagca tgaagagaag cttgtggata ttattctgac agaaacgacc actttgggaa 12541 tcagaaagac caccgcccaa agatatgttc ttgaaaggga aataaaacat gtgaatactg 12601 agtttgggaa aataagagtg aaagagtcgt cctttggcga ttacaagaaa tattcgccgg 12661 aatttgaaga ctgtaaaaaa gtggcccagg aattgaaaat accgctgtca aaggtatatg 12721 atgccgtaaa caaagctatt ttagtatttg aagaaaggaa tgaaaatgct ttacaataag 12781 ttttcaactt atttaaaaca aaaatatggc acaaaagttt ataagctccc tttgaacctt 12841 ccggtcacat gtccgaaccg tgacggcaga ataagcagca aaggatgcat attttgcggg 12901 gaagagggag ccggttttga aaatctcccc aattttcttg gaataaaaga acagctgaaa 12961 ttaaactcca ggtatattgg aaaaaactat gggtctgaaa agtttatagc atattttcaa 13021 aattacacaa atacttatct tcctttggag gactttaaaa ggcatattaa tgacgcttta 13081 gaggaaaaca ttgtggccgt ttatatttcc acccgccctg attgcgtcag ggattcgtat 13141 ctttcttttc tgaaagagat aaagctgtca aaaggggtgg acatagtaat agagcttgga 13201 cttcagacgg taaactacca taccttgaaa cttcttaaca gggggcatct gcttgcagaa 13261 tttatagatg ccgtgctggc aataaaaaga tacggtcttg agtcttgcgc ccactatata 13321 ctggatatac ccatggattc aatggatgac gtaatcgagg gggcaaggat attgtcagct 13381 ttaggtgtaa accaggtaaa gtgccattct ctttatattt taaaagatac cgttttgggg 13441 gaaatgtata agaggggaga gataaagcat gtaactttgg aagaatatat tgaaagggcg 13501 atatcgtttc ttgagtatct tgacccgtct attgtcatac aaaggctcat aggacgtgcg 13561 cctgaggaaa gaagcttgtt ttgcaattgg ggcatgagtt ggtggaaaat acatgacagc 13621 attgagcgga aaatgacaga agaaaacaga tatcagggca aaaaatttga ttatttgaac 13681 ggaagagctc ttgacggtat ggactgaaag atggatacag gcttggaata gactaaaagc 13741 tagatacagg cttaaaaata taaaatgata agaggagata tatgagggat aaaaaatgat 13801 ataatgatat aaagatataa aagtgagata taggatgata attgtaaacg ggaagatcgt 13861 aatataaaat aaaaacggtc tcatgtcaaa acatcaaaca gagacctttt tattttatta 13921 ttat //