ENTRY       EC 1.14.18.1
NAME        Monophenol monooxygenase
            Tyrosinase
            Phenolase
            Monophenol oxidase
            Cresolase
SYSNAME     Monophenol,L-dopa:oxygen oxidoreductase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With another compound as one donor, and incorporation of one atom
            of oxygen
REACTION    L-Tyrosine + L-Dopa + O2 = L-Dopa + Dopaquinone + H2O
SUBSTRATE   L-Tyrosine
            L-Dopa
            Benzenediol
            O2
PRODUCT     L-Dopa
            Dopaquinone
            H2O
COFACTOR    Copper
COMMENT     A group of copper proteins that also catalyse the reaction of
            EC 1.10.3.1, if only benzenediols are available as substrate.
            (EC 1.10.3.1 Catechol oxidase)
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00740  Riboflavin metabolism
            PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
            PATH: MAP00950  Alkaloid biosynthesis I
GENES       DME: CG5779
            MMU: 94856 98880(Tyr)
            HSA: 7299(TYR)
DISEASE     MIM: 203100  Tyrosinase
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.18.1
            ExPASy - ENZYME nomenclature database: 1.14.18.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.18.1
            BRENDA, the Enzyme Database: 1.14.18.1
///
ENTRY       EC 3.4.21.50
NAME        Lysyl endopeptidase
            Achromobacter proteinase I
            Endoproteinase Lys-C
            Ps-1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Lys+, including -Lys-|-Pro-
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A chymotrypsin homologue isolated from Achromobacter lyticus.
            Enzymes with similar specificity are produced by Lysobacter
            enzymogenes (Endoproteinase Lys-C) and Pseudomonas aeruginosa
            (Ps-1).
COMMENT     Also hydrolyses lysine amides and esters.
GENES       MJA: MJ1468
            MTH: MTH995
STRUCTURES  PDB: 1ARC  1ARB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.50
            ExPASy - ENZYME nomenclature database: 3.4.21.50
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.50
            BRENDA, the Enzyme Database: 3.4.21.50
            SCOP (Structural Classification of Proteins): 3.4.21.50
///