ID   TCMO_STRGA     STANDARD;      PRT;   339 AA.
AC   P39896;
DT   01-FEB-1995 (REL. 31, CREATED)
DT   01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE)
DT   01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE)
DE   TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYL TRANSFERASE TCMO
DE   (EC 2.1.1.-).
GN   TCMO.
OS   STREPTOMYCES GLAUCESCENS.
OC   BACTERIA; FIRMICUTES; ACTINOBACTERIA; ACTINOBACTERIDAE;
OC   ACTINOMYCETALES; STREPTOMYCINEAE; STREPTOMYCETACEAE; STREPTOMYCES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=GLA.0;
RX   MEDLINE; 92193265.
RA   SUMMERS R.G., WENDT-PIENKOWSKI E., MOTAMEDI H., HUTCHINSON C.R.;
RT   "Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin
RT   C biosynthetic gene cluster of Streptomyces glaucescens and evidence
RT   that the tcmN gene encodes a multifunctional
RT   cyclase-dehydratase-O-methyl transferase.";
RL   J. BACTERIOL. 174:1810-1820(1992).
CC       TETRACENOMYCIN B3 TO TETRACENOMYCIN E. METHYLATES AS WELL TCM D3
CC       INTO 8-O-METHYL-TCM D3, A SIDE REACTION.
CC   -!- PATHWAY: SECOND STEP IN THE BIOSYNTHESIS OF THE POLYKETIDE
CC       ANTIBIOTIC TETRACENOMYCIN C (TCM C) FROM TCM D3.
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DR   EMBL; M80674; G153500; -.
DR   PIR; S27697; S27697.
DR   PIR; C42276; C42276.
DR   PFAM; PF00891; Methyltransf; 1.
KW   ANTIBIOTIC BIOSYNTHESIS; TRANSFERASE; METHYLTRANSFERASE.
SQ   SEQUENCE   339 AA;  37035 MW;  848B7337 CRC32;
     MTPHTHVRGP GDILQLTMAF YGSRALISAV ELDLFTLLAG KPLPLGELCE RAGIHPRGAR
     DFLDALVALG LLEREGEDTY RNSPAADRHL DRRKPGYVGG YARLADTKLF PVWARLTEAL
     RTGEKQVPSQ GGFFGGYADP EAARGFLGAM DAVNGGVGHS LAGALDWTEY SSFVDLGGAR
     GNLAAHLHRA HPHLRATCFD LPEMEPFFQE HMKSLETTDQ VRFAGGDFFT DPLPRADVFI
     VGHILHYFGL RQREALIARI HQALTPGGAV LVYDRMIDDD RRSAALSLLG SLNMLLTSDE
     GREYTPAECV RWLSDAGFTD VRTTAVSGPD TLAIGRKPR
//