ID   CLD1_HUMAN     STANDARD;      PRT;   211 AA.
AC   O95832;
DT   15-FEB-2000 (Rel. 39, Created)
DT   15-FEB-2000 (Rel. 39, Last sequence update)
DT   15-FEB-2000 (Rel. 39, Last annotation update)
DE   CLAUDIN-1 (SENESCENCE-ASSOCIATED EPITHELIAL MEMBRANE PROTEIN).
GN   CLDN1 OR CLD1 OR SEMP1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC   Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 99132301. [NCBI, ExPASy, Israel, Japan]
RA   Swisshelm K.L., Machl A., Planitzer S., Robertson R., Kubbies M.,
RA   Hosier S.;
RT   "SEMP1, a senescence-associated cDNA isolated from human mammary
RT   epithelial cells, is a member of an epithelial membrane protein
RT   superfamily.";
RL   Gene 226:285-295(1999).
RN   [2]
RP   SEQUENCE FROM N.A.
RA   Mitic L.M., Anderson J.M.;
RT   "Human claudin-1 isolated from Caco-2 mRNA.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: COMPONENT OF TIGHT JUNCTION (TJ) STRANDS.
CC   -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC   -!- SIMILARITY: BELONGS TO THE CLAUDIN FAMILY.
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DR   EMBL; AF101051; AAD16433.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AF115546; AAD22962.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   GeneCards; CLDN1.
DR   MIM; 603718; -.
DR   PROSITE; PS01346; CLAUDIN; 1.
DR   PRODOM [Domain structure / List of seq. sharing at least 1 domain]
DR   BLOCKS; O95832.
DR   DOMO; O95832.
DR   PROTOMAP; O95832.
DR   PRESAGE; O95832.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Tight junction; Transmembrane.
FT   TRANSMEM      8     28       POTENTIAL.
FT   TRANSMEM     82    102       POTENTIAL.
FT   TRANSMEM    116    136       POTENTIAL.
FT   TRANSMEM    164    184       POTENTIAL.
FT   CONFLICT     62     62       I -> V (IN REF. 2).
FT   CONFLICT    135    135       V -> A (IN REF. 2).
SQ   SEQUENCE   211 AA;  22744 MW;  07269000E6C214F0 CRC64;
     MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG
     QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV
     IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA
     LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V
//