ID   5H4_HUMAN      STANDARD;      PRT;   388 AA.
AC   Q13639; Q9UBM6; Q9UQR6; Q9UE22; Q9UE23; Q9UBT4; Q9NY73;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-OCT-2000 (Rel. 40, Last sequence update)
DT   01-OCT-2000 (Rel. 40, Last annotation update)
DE   5-HYDROXYTRYPTAMINE 4 RECEPTOR (5-HT-4) (SEROTONIN RECEPTOR) (5-HT4).
GN   HTR4.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A); 5-HT4(B); 5-HT4(C); 5-HT4(D)).
RC   TISSUE=Gut;
RX   PubMed=9603189;
RA   Blondel O., Gastineau M., Dahmoune Y., Langlois M., Fischmeister R.;
RT   "Cloning, expression, and pharmacology of four human 5-
RT   hydroxytryptamine receptor isoforms produced by alternative splicing
RT   in the carboxyl terminus.";
RL   J. Neurochem. 70:2252-2261(1998).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A) AND 5HT4(B)).
RC   TISSUE=Brain;
RA   Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R.,
RA   Leysen J., Luyten W., Bender E.;
RT   "Cloning and expression of 5-HT4 receptor species and splice
RT   variants.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORM 5-HT4(A)).
RC   TISSUE=Heart;
RX   PubMed=9351641;
RA   Claeysen S., Faye P., Sebben M., Lemaire S., Bockaert J., Dumuis A.;
RT   "Cloning and expression of human 5-HT4S receptors. Effect of receptor
RT   density on their coupling to adenylyl cyclase.";
RL   NeuroReport 8:3189-3195(1997).
RN   [4]
RP   SEQUENCE FROM N.A. (ISOFORM 5-HT4(E)).
RC   TISSUE=Brain;
RA   Claeysen S., Sebben M., Becamel C., Bockaert J., Dumuis A.;
RT   "Novel brain-specific 5-HT4 receptors splice variants show marked
RT   constitutive activity: role of the c-terminal intracellular domain.";
RL   Mol. Pharmacol. 55:0-0(1999).
RN   [5]
RP   SEQUENCE OF 10-388 FROM N.A. (ISOFORM 5-HT4(F)).
RX   PubMed=10646498;
RA   Bender E., Pindon A., van Oers I., Zhang Y.B., Gommeren W.,
RA   Verhasselt P., Jurzak M., Leysen J., Luyten W.;
RT   "Structure of the human serotonin 5-HT4 receptor gene and cloning of a
RT   novel 5-HT4 splice variant.";
RL   J. Neurochem. 74:478-489(2000).
RN   [6]
RP   SEQUENCE OF 112-255 FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=95385798; PubMed=7656980;
RA   Ullmer C., Schmuck K., Kalkman H.O., Lubbert H.;
RT   "Expression of serotonin receptor mRNAs in blood vessels.";
RL   FEBS Lett. 370:215-221(1995).
CC   -!- FUNCTION: THIS IS ONE OF THE SEVERAL DIFFERENT RECEPTORS FOR
CC       5-HYDROXYTRYPTAMINE (SEROTONIN), A BIOGENIC HORMONE THAT FUNCTION
CC       AS A NEUROTRANSMITTER, A HORMONE, AND A MITOGEN. THE ACTIVITY OF
CC       THIS RECEPTOR IS MEDIATED BY G PROTEINS THAT STIMULATES ADENYLATE
CC       CYCLASE.
CC   -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC   -!- ALTERNATIVE PRODUCTS: AT LEAST 6 ISOFORMS; 5-HT4(A)/5-HT4S, 5-
CC       HT4(B) (SHOWN HERE), 5-HT4(C), 5-HT4(D); 5-HT4(E) AND 5-HT4(F);
CC       ARE PRODUCED BY ALTERNATIVE SPLICING.
CC   -!- TISSUE SPECIFICITY: ISOFORM 5-HT4(A)IS EXPRESSED IN ILEUM, BRAIN,
CC       AND ATRIUM, BUT NOT IN THE VENTRICLE.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC   --------------------------------------------------------------------------
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CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
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DR   EMBL; Y12505; CAA73107.1; -.
DR   EMBL; Y12506; CAA73108.1; -.
DR   EMBL; Y12507; CAA73109.1; -.
DR   EMBL; Y10437; CAA71462.1; -.
DR   EMBL; Y08756; CAA70002.1; -.
DR   EMBL; Y09586; CAA70774.1; -.
DR   EMBL; Y13584; CAA73911.1; -.
DR   EMBL; AJ011371; CAA09600.1; -.
DR   EMBL; AJ243213; CAB71316.1; -.
DR   EMBL; Z48150; CAA88167.1; -.
DR   GCRDb; GCR_1064; -.
DR   MIM; 602164; -.
DR   InterPro; IPR000276; -.
DR   InterPro; IPR001520; -.
DR   InterPro; IPR002233; -.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01059; 5HT4RECEPTR.
DR   PRINTS; PR01103; ADRENERGICR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   G-protein coupled receptor; Transmembrane; Glycoprotein;
KW   Multigene family; Lipoprotein; Palmitate; Alternative splicing.
FT   DOMAIN        1     19       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     20     40       1 (POTENTIAL).
FT   DOMAIN       41     58       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     59     79       2 (POTENTIAL).
FT   DOMAIN       80     93       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM     94    116       3 (POTENTIAL).
FT   DOMAIN      117    137       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    138    158       4 (POTENTIAL).
FT   DOMAIN      159    192       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    193    213       5 (POTENTIAL).
FT   DOMAIN      214    260       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    261    281       6 (POTENTIAL).
FT   DOMAIN      282    294       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    295    315       7 (POTENTIAL).
FT   DOMAIN      316    388       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD      7      7       N-LINKED (GLCNAC...) (POTENTIAL).
FT   DISULFID     93    184       BY SIMILARITY.
FT   LIPID       329    329       PALMITATE (BY SIMILARITY).
FT   VARSPLIC    169    169       L -> LERSLNQGLGQDFHA (IN ISOFORM 5-
FT                                HT4(F)).
FT   VARSPLIC    359    388       RDAVECGGQWESQCHPPATSPLVAAQPSDT -> SGCSPVS
FT                                SFLLLFCNRPVPV (IN ISOFORM 5-HT4(E)).
FT   VARSPLIC    359    388       RDAVECGGQWESQCHPPATSPLVAAQPSDT -> SSGTETD
FT                                RRNFGIRKRRLTKPS (IN ISOFORM 5-HT4(D)).
FT   VARSPLIC    360    388       DAVECGGQWESQCHPPATSPLVAAQPSDT -> F (IN
FT                                ISOFORM 5-HT4(C)).
FT   VARSPLIC    360    388       DAVECGGQWESQCHPPATSPLVAAQPSDT -> YTVLHRGH
FT                                HQELEKLPIHNDPESLESCF (IN ISOFORM 5-
FT                                HT4(A)).
SQ   SEQUENCE   388 AA;  43761 MW;  7FCFEC60E7BDF560 CRC64;
     MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV
     SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY
     AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN
     STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP
     QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL
     GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD
     AVECGGQWES QCHPPATSPL VAAQPSDT
//