1 Immunoglobulin C-2 Type 14 WD40 repeats 25 Tyrosine kinase, catalytic domain 25 Tyrosine kinase, catalytic domain 27 Tyrosine kinase, catalytic domain 27 Tyrosine kinase, catalytic domain 27 Src homology 2 domains 27 Src homology 3 domains 29 GTPase-activator protein for Rho-like GTPases 29 GTPase-activator protein for Rho-like GTPases 49 Trypsin-like serine protease 52 Low molecular weight phosphatase family 52 Low molecular weight phosphatase family 52 Low molecular weight phosphatase family 58 Actin 72 Actin 86 Actin 86 Actin 86 Actin 90 GS motif 94 GS motif 101 ADAM Cysteine-Rich Domain 101 Homologues of snake disintegrins 102 Homologues of snake disintegrins 103 Double-stranded RNA binding motif 103 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 103 Double-stranded RNA binding motif 103 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 103 Double-stranded RNA binding motif 103 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 104 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 104 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 104 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 105 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 107 Adenylyl- / guanylyl cyclase, catalytic domain 117 Domain present in hormone receptors 143 Vault protein Inter-alpha-Trypsin domain 143 von Willebrand factor (vWF) type A domain 156 Serine/Threonine protein kinases, catalytic domain 156 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 157 Serine/Threonine protein kinases, catalytic domain 157 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 165 Zn_pept domain 167 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 167 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 174 serum albumin 176 Immunoglobulin V-Type 176 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 176 Immunoglobulin V-Type 176 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 177 Immunoglobulin 177 Immunoglobulin C-2 Type 177 Immunoglobulin 182 von Willebrand factor (vWF) type C domain 202 Beta/gamma crystallins 202 Ricin-type beta-trefoil 207 Serine/Threonine protein kinases, catalytic domain 207 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 208 Serine/Threonine protein kinases, catalytic domain 208 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 213 serum albumin 214 Immunoglobulin 214 Immunoglobulin V-Type 238 Tyrosine kinase, catalytic domain 240 Lipoxygenase homology 2 (beta barrel) domain 246 Lipoxygenase homology 2 (beta barrel) domain 259 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 268 Transforming growth factor-beta (TGF-beta) family 273 Src homology 3 domains 273 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 274 Src homology 3 domains 284 Fibrinogen-related domains (FReDs) 284 Fibrinogen-related domains (FReDs) 285 Fibrinogen-related domains (FReDs) 286 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 286 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 286 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 286 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 287 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 287 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 288 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 288 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 309 Annexin repeats 324 Armadillo/beta-catenin-like repeats 329 Baculoviral inhibition of apoptosis protein repeat 330 Baculoviral inhibition of apoptosis protein repeat 331 Baculoviral inhibition of apoptosis protein repeat 332 Baculoviral inhibition of apoptosis protein repeat 334 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 350 Domain abundant in complement control proteins 351 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 354 Trypsin-like serine protease 355 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 355 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 356 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 357 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 373 Ring finger 373 B-Box C-terminal domain 373 Ring finger 373 B-Box C-terminal domain 373 Ring finger 373 B-Box C-terminal domain 375 ARF-like small GTPases 377 ARF-like small GTPases 378 ARF-like small GTPases 381 ARF-like small GTPases 382 ARF-like small GTPases 382 Sar1p-like members of the Ras-family of small GTPases 387 Rho (Ras homology) subfamily of Ras-like small GTPases 388 Rho (Ras homology) subfamily of Ras-like small GTPases 389 Rho (Ras homology) subfamily of Ras-like small GTPases 390 Rho (Ras homology) subfamily of Ras-like small GTPases 391 Rho (Ras homology) subfamily of Ras-like small GTPases 392 GTPase-activator protein for Rho-like GTPases 392 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 394 Rab subfamily of small GTPases 394 Contains two conserved F residues 394 GTPase-activator protein for Rho-like GTPases 395 GTPase-activator protein for Rho-like GTPases 395 GTPase-activator protein for Rho-like GTPases 395 GTPase-activator protein for Rho-like GTPases 395 GTPase-activator protein for Rho-like GTPases 395 GTPase-activator protein for Rho-like GTPases 399 Rho (Ras homology) subfamily of Ras-like small GTPases 405 PAS domain 405 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 405 PAS domain 405 PAS domain 405 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 406 PAS domain 421 Armadillo/beta-catenin-like repeats 429 helix loop helix domain 430 helix loop helix domain 460 membrane-attack complex / perforin 467 basic region leucin zipper 469 basic region leucin zipper 473 Bromo adjacent homology domain 473 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 473 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 474 helix loop helix domain 550 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 550 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 550 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 558 Immunoglobulin 558 Tyrosine kinase, catalytic domain 558 Immunoglobulin 558 Tyrosine kinase, catalytic domain 563 Immunoglobulin C-Type 566 Trypsin-like serine protease 567 Immunoglobulin C-Type 571 basic region leucin zipper 573 Ubiquitin homologues 575 Thrombospondin type 1 repeats 576 Thrombospondin type 1 repeats 577 Thrombospondin type 1 repeats 580 breast cancer carboxy-terminal domain 581 BCL (B-Cell lymphoma) 581 BCL (B-Cell lymphoma) 596 BH4 Bcl-2 homology region 4 596 BH4 Bcl-2 homology region 4 598 BH4 Bcl-2 homology region 4 598 BH4 Bcl-2 homology region 4 599 BH4 Bcl-2 homology region 4 613 Protein kinase C conserved region 2 (CalB) 613 Protein kinase C conserved region 2 (CalB) 629 Trypsin-like serine protease 629 Domain abundant in complement control proteins 632 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 634 Immunoglobulin 634 Immunoglobulin C-2 Type 639 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 640 Tyrosine kinase, catalytic domain 649 Calcium-binding EGF-like domain 649 Epidermal growth factor-like domain 649 Calcium-binding EGF-like domain 649 Epidermal growth factor-like domain 649 Calcium-binding EGF-like domain 649 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 649 Calcium-binding EGF-like domain 649 Epidermal growth factor-like domain 649 Calcium-binding EGF-like domain 649 Epidermal growth factor-like domain 650 Transforming growth factor-beta (TGF-beta) family 651 Transforming growth factor-beta (TGF-beta) family 652 Transforming growth factor-beta (TGF-beta) family 652 Transforming growth factor-beta (TGF-beta) family 652 Transforming growth factor-beta (TGF-beta) family 653 Transforming growth factor-beta (TGF-beta) family 654 Transforming growth factor-beta (TGF-beta) family 655 Transforming growth factor-beta (TGF-beta) family 656 Transforming growth factor-beta (TGF-beta) family 660 Src homology 2 domains 660 Tyrosine kinase, catalytic domain 660 Bruton's tyrosine kinase Cys-rich motif 660 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 663 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 667 Spectrin repeats 667 Spectrin repeats 667 Spectrin repeats 668 FORKHEAD 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 672 breast cancer carboxy-terminal domain 676 bromo domain 682 Immunoglobulin 695 Src homology 2 domains 695 Tyrosine kinase, catalytic domain 695 Bruton's tyrosine kinase Cys-rich motif 695 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 696 Immunoglobulin V-Type 696 associated with SPRY domains 699 Serine/Threonine protein kinases, catalytic domain 701 Serine/Threonine protein kinases, catalytic domain 712 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 713 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 714 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 715 Trypsin-like serine protease 715 Calcium-binding EGF-like domain 715 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 716 Trypsin-like serine protease 716 Calcium-binding EGF-like domain 716 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 717 Trypsin-like serine protease 717 Domain abundant in complement control proteins 722 Domain abundant in complement control proteins 725 Domain abundant in complement control proteins 726 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 729 Thrombospondin type 1 repeats 729 factor I membrane attack complex 730 factor I membrane attack complex 730 Domain abundant in complement control proteins 732 Low-density lipoprotein receptor domain class A 752 Formin Homology 2 Domain 780 Tyrosine kinase, catalytic domain 780 Tyrosine kinase, catalytic domain 780 Tyrosine kinase, catalytic domain 781 von Willebrand factor (vWF) type A domain 782 Src homology 3 domains 783 Src homology 3 domains 785 Src homology 3 domains 795 EF-hand, calcium binding motif 796 calcitonin 797 calcitonin 814 Serine/Threonine protein kinases, catalytic domain 815 Serine/Threonine protein kinases, catalytic domain 815 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 816 Serine/Threonine protein kinases, catalytic domain 817 Serine/Threonine protein kinases, catalytic domain 817 Serine/Threonine protein kinases, catalytic domain 817 Serine/Threonine protein kinases, catalytic domain 817 Serine/Threonine protein kinases, catalytic domain 818 Serine/Threonine protein kinases, catalytic domain 818 Serine/Threonine protein kinases, catalytic domain 818 Serine/Threonine protein kinases, catalytic domain 818 Serine/Threonine protein kinases, catalytic domain 818 Serine/Threonine protein kinases, catalytic domain 818 Serine/Threonine protein kinases, catalytic domain 822 Gelsolin homology domain 825 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 825 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 825 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 827 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 834 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 834 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 834 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 834 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 835 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 836 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 836 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 837 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 837 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 837 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 838 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 839 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 839 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 840 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 840 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 840 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 841 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 841 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 841 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 841 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 842 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 842 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 843 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 843 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 843 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 862 TAF homology 862 TAF homology 862 TAF homology 862 TAF homology 863 TAF homology 863 TAF homology 867 Ring finger 867 Ubiquitin associated domain 868 Ring finger 868 Ubiquitin associated domain 869 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 875 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 889 Band 4.1 homologues 899 A Receptor for Ubiquitination Targets 900 domain present in cyclins, TFIIB and Retinoblastoma 901 domain present in cyclins, TFIIB and Retinoblastoma 909 Immunoglobulin C-Type 910 Immunoglobulin C-Type 911 Immunoglobulin C-Type 912 Immunoglobulin C-Type 913 Immunoglobulin C-Type 915 Immunoreceptor tyrosine-based activation motif 916 Immunoglobulin C-2 Type 917 Immunoglobulin C-2 Type 920 Immunoglobulin V-Type 922 Scavenger receptor Cys-rich 923 Scavenger receptor Cys-rich 924 Immunoglobulin 925 Immunoglobulin 925 Immunoglobulin 926 Immunoglobulin 926 Immunoglobulin 926 Immunoglobulin 926 Immunoglobulin 926 Immunoglobulin 926 Immunoglobulin V-Type 930 Immunoglobulin 933 Immunoglobulin 933 Immunoglobulin C-2 Type 940 Immunoglobulin V-Type 941 Immunoglobulin 942 Immunoglobulin V-Type 942 Immunoglobulin V-Type 943 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 945 Immunoglobulin V-Type 946 Immunoglobulin 958 Tumor necrosis factor receptor / nerve growth factor receptor repeats 960 Link (Hyaluronan-binding) 969 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 971 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 973 Immunoglobulin 974 Immunoglobulin 976 Calcium-binding EGF-like domain 976 Calcium-binding EGF-like domain 983 Serine/Threonine protein kinases, catalytic domain 983 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 984 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 985 Serine/Threonine protein kinases, catalytic domain 998 Rho (Ras homology) subfamily of Ras-like small GTPases 998 Rho (Ras homology) subfamily of Ras-like small GTPases 999 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1000 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1001 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1002 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1003 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1004 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1005 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1005 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1006 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1007 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1008 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1009 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1009 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1010 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1012 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1013 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1014 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1015 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1016 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1017 Serine/Threonine protein kinases, catalytic domain 1017 Serine/Threonine protein kinases, catalytic domain 1018 Serine/Threonine protein kinases, catalytic domain 1019 Serine/Threonine protein kinases, catalytic domain 1019 Serine/Threonine protein kinases, catalytic domain 1021 Serine/Threonine protein kinases, catalytic domain 1022 Serine/Threonine protein kinases, catalytic domain 1024 Serine/Threonine protein kinases, catalytic domain 1025 Serine/Threonine protein kinases, catalytic domain 1048 Immunoglobulin 1050 basic region leucin zipper 1051 basic region leucin zipper 1052 basic region leucin zipper 1053 basic region leucin zipper 1054 basic region leucin zipper 1058 Histone H3 1059 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 1062 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 1071 BPI/LBP/CETP N-terminal domain 1072 Actin depolymerisation factor/cofilin -like domains 1073 Actin depolymerisation factor/cofilin -like domains 1082 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 1087 Immunoglobulin 1088 Immunoglobulin 1106 Chromatin organization modifier domain 1108 Chromatin organization modifier domain 1111 Serine/Threonine protein kinases, catalytic domain 1112 FORKHEAD 1116 Glyco_18 domain 1117 Glyco_18 domain 1118 Glyco_18 domain 1118 Chitin-binding domain type 2 1123 Src homology 2 domains 1124 Src homology 2 domains 1130 WD40 repeats 1147 Serine/Threonine protein kinases, catalytic domain 1153 RNA recognition motif 1154 Src homology 2 domains 1154 suppressors of cytokine signalling 1154 Src homology 2 domains 1154 suppressors of cytokine signalling 1179 von Willebrand factor (vWF) type A domain 1185 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 1191 CLUSTERIN alpha chain 1195 Serine/Threonine protein kinases, catalytic domain 1196 Serine/Threonine protein kinases, catalytic domain 1198 Serine/Threonine protein kinases, catalytic domain 1208 Colipase 1213 Clathrin heavy chain repeat homology 1215 Trypsin-like serine protease 1262 Cyclic nucleotide-monophosphate binding domain 1263 Serine/Threonine protein kinases, catalytic domain 1271 Immunoglobulin C-2 Type 1271 Fibronectin type 3 domain 1271 Immunoglobulin C-2 Type 1271 Fibronectin type 3 domain 1272 Immunoglobulin 1272 Immunoglobulin C-2 Type 1272 Immunoglobulin 1272 Immunoglobulin C-2 Type 1278 Fibrillar collagens C-terminal domain 1280 Fibrillar collagens C-terminal domain 1280 Fibrillar collagens C-terminal domain 1281 Fibrillar collagens C-terminal domain 1282 C-terminal tandem repeated domain in type 4 procollagens 1285 C-terminal tandem repeated domain in type 4 procollagens 1287 C-terminal tandem repeated domain in type 4 procollagens 1287 C-terminal tandem repeated domain in type 4 procollagens 1287 C-terminal tandem repeated domain in type 4 procollagens 1289 Fibrillar collagens C-terminal domain 1289 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1290 Fibrillar collagens C-terminal domain 1291 von Willebrand factor (vWF) type A domain 1292 von Willebrand factor (vWF) type A domain 1292 von Willebrand factor (vWF) type A domain 1292 von Willebrand factor (vWF) type A domain 1293 Fibronectin type 3 domain 1293 von Willebrand factor (vWF) type A domain 1293 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 1293 Fibronectin type 3 domain 1293 von Willebrand factor (vWF) type A domain 1293 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 1293 Fibronectin type 3 domain 1293 von Willebrand factor (vWF) type A domain 1293 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 1293 Fibronectin type 3 domain 1293 von Willebrand factor (vWF) type A domain 1293 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 1293 Fibronectin type 3 domain 1293 von Willebrand factor (vWF) type A domain 1293 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 1294 Fibronectin type 3 domain 1294 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 1296 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 1297 Thrombospondin N-terminal -like domains. 1301 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1301 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1301 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1302 Laminin G domain 1302 Fibrillar collagens C-terminal domain 1302 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1302 Laminin G domain 1302 Fibrillar collagens C-terminal domain 1302 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1302 Laminin G domain 1302 Fibrillar collagens C-terminal domain 1302 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 1303 Fibronectin type 3 domain 1303 Fibronectin type 3 domain 1311 Calcium-binding EGF-like domain 1326 Serine/Threonine protein kinases, catalytic domain 1361 Zn_pept domain 1361 Zn_pept domain 1362 Zn_pept domain 1378 Domain abundant in complement control proteins 1378 Domain abundant in complement control proteins 1379 Domain abundant in complement control proteins 1380 Domain abundant in complement control proteins 1386 basic region leucin zipper 1387 bromo domain 1388 basic region leucin zipper 1394 Domain present in hormone receptors 1395 Domain present in hormone receptors 1398 Src homology 3 domains 1398 Src homology 3 domains 1399 Src homology 3 domains 1401 Pentraxin / C-reactive protein / pentaxin family 1404 Immunoglobulin V-Type 1432 Serine/Threonine protein kinases, catalytic domain 1432 Serine/Threonine protein kinases, catalytic domain 1432 Serine/Threonine protein kinases, catalytic domain 1432 Serine/Threonine protein kinases, catalytic domain 1436 Immunoglobulin 1436 Tyrosine kinase, catalytic domain 1439 Fibronectin type 3 domain 1445 Src homology 2 domains 1445 Src homology 3 domains 1445 Tyrosine kinase, catalytic domain 1457 Serine/Threonine protein kinases, catalytic domain 1462 Calcium-binding EGF-like domain 1462 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 1463 Link (Hyaluronan-binding) 1463 Calcium-binding EGF-like domain 1463 Domain abundant in complement control proteins 1463 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 1464 Laminin G domain 1469 Cystatin-like domain 1470 Cystatin-like domain 1471 Cystatin-like domain 1472 Cystatin-like domain 1473 Cystatin-like domain 1474 Cystatin-like domain 1486 Glyco_18 domain 1490 von Willebrand factor (vWF) type C domain 1490 C-terminal cystine knot-like domain (CTCK) 1490 Insulin growth factor-binding protein homologues 1493 Immunoglobulin V-Type 1500 Armadillo/beta-catenin-like repeats 1501 Armadillo/beta-catenin-like repeats 1504 Trypsin-like serine protease 1506 Trypsin-like serine protease 1511 Trypsin-like serine protease 1512 Papain family cysteine protease 1513 Papain family cysteine protease 1514 Papain family cysteine protease 1514 Papain family cysteine protease 1519 Papain family cysteine protease 1520 Papain family cysteine protease 1521 Papain family cysteine protease 1525 Immunoglobulin 1525 Immunoglobulin V-Type 1604 Domain abundant in complement control proteins 1607 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 1607 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 1608 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 1609 Diacylglycerol kinase accessory domain (presumed) 1609 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 1612 Serine/Threonine protein kinases, catalytic domain 1612 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 1613 Serine/Threonine protein kinases, catalytic domain 1617 RNA recognition motif 1617 RNA recognition motif 1618 RNA recognition motif 1620 membrane-attack complex / perforin 1628 basic region leucin zipper 1630 Immunoglobulin 1630 Immunoglobulin C-2 Type 1630 Fibronectin type 3 domain 1641 Domain in the Doublecortin (DCX) gene product 1641 Domain in the Doublecortin (DCX) gene product 1641 Domain in the Doublecortin (DCX) gene product 1641 Domain in the Doublecortin (DCX) gene product 1649 basic region leucin zipper 1653 Domain in SPla and the RYanodine Receptor. 1660 Double-stranded RNA binding motif 1663 DEAD-like helicases superfamily 1663 DEAD-like helicases superfamily 1663 DEAD-like helicases superfamily 1664 DEAD-like helicases superfamily 1675 Trypsin-like serine protease 1729 Formin Homology 2 Domain 1730 Formin Homology 2 Domain 1730 Formin Homology 2 Domain 1736 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 1739 Src homology 3 domains 1739 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 1739 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 1740 Src homology 3 domains 1740 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 1740 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 1741 Src homology 3 domains 1741 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 1741 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 1742 Src homology 3 domains 1742 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 1742 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 1755 Scavenger receptor Cys-rich 1755 Scavenger receptor Cys-rich 1755 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 1755 Scavenger receptor Cys-rich 1755 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 1755 Scavenger receptor Cys-rich 1755 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 1756 Spectrin repeats 1756 Calponin homology domain 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Calponin homology domain 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Calponin homology domain 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1756 Spectrin repeats 1756 Domain with 2 conserved Trp (W) residues 1760 Serine/Threonine protein kinases, catalytic domain 1761 Doublesex DNA-binding motif 1762 WD40 repeats 1773 deoxyribonuclease I 1774 deoxyribonuclease I 1775 deoxyribonuclease I 1776 deoxyribonuclease I 1791 DNA polymerase X family 1793 Src homology 3 domains 1794 Src homology 3 domains 1794 Src homology 3 domains 1795 Src homology 3 domains 1821 Spectrin repeats 1821 Domain with 2 conserved Trp (W) residues 1824 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1824 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1825 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1825 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1826 Immunoglobulin 1826 Immunoglobulin C-2 Type 1826 Fibronectin type 3 domain 1829 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1830 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1832 Plectin repeat 1843 Rhodanese Homology Domain 1846 Rhodanese Homology Domain 1847 Rhodanese Homology Domain 1848 Rhodanese Homology Domain 1848 Rhodanese Homology Domain 1849 Rhodanese Homology Domain 1849 Dual specificity phosphatase, catalytic domain 1850 Rhodanese Homology Domain 1855 Domain present in Dishevelled and axin 1855 Domain found in Dishevelled, Egl-10, and Pleckstrin 1855 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 1859 Serine/Threonine protein kinases, catalytic domain 1859 Serine/Threonine protein kinases, catalytic domain 1859 Serine/Threonine protein kinases, catalytic domain 1859 Serine/Threonine protein kinases, catalytic domain 1859 Serine/Threonine protein kinases, catalytic domain 1879 helix loop helix domain 1894 breast cancer carboxy-terminal domain 1894 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 1896 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 1906 Endothelin 1907 Endothelin 1908 Endothelin 1911 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 1950 Calcium-binding EGF-like domain 1950 Low-density lipoprotein-receptor YWTD domain 1951 Laminin G domain 1951 Calcium-binding EGF-like domain 1951 Domain present in hormone receptors 1951 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1952 Laminin G domain 1952 Domain present in hormone receptors 1952 G-protein-coupled receptor proteolytic site domain 1952 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 1956 Tyrosine kinase, catalytic domain 1969 Fibronectin type 3 domain 1969 Tyrosine kinase, catalytic domain 1969 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 1975 RNA recognition motif 1990 Trypsin-like serine protease 1991 Trypsin-like serine protease 1993 RNA recognition motif 1994 RNA recognition motif 1995 RNA recognition motif 1996 RNA recognition motif 1997 erythroblast transformation specific domain 1998 erythroblast transformation specific domain 1999 SAM / Pointed domain 1999 erythroblast transformation specific domain 2000 erythroblast transformation specific domain 2001 SAM / Pointed domain 2001 erythroblast transformation specific domain 2011 Serine/Threonine protein kinases, catalytic domain 2011 Serine/Threonine protein kinases, catalytic domain 2015 Calcium-binding EGF-like domain 2017 Src homology 3 domains 2017 Src homology 3 domains 2021 DNA/RNA non-specific endonuclease 2022 Zona pellucida (ZP) domain 2034 PAS domain 2034 helix loop helix domain 2039 Villin headpiece domain 2041 Fibronectin type 3 domain 2041 Tyrosine kinase, catalytic domain 2042 Fibronectin type 3 domain 2042 Tyrosine kinase, catalytic domain 2042 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 2042 Fibronectin type 3 domain 2043 Fibronectin type 3 domain 2043 Tyrosine kinase, catalytic domain 2044 Fibronectin type 3 domain 2044 Tyrosine kinase, catalytic domain 2044 Fibronectin type 3 domain 2044 Tyrosine kinase, catalytic domain 2045 Fibronectin type 3 domain 2045 Tyrosine kinase, catalytic domain 2045 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 2046 Fibronectin type 3 domain 2046 Tyrosine kinase, catalytic domain 2046 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 2047 Fibronectin type 3 domain 2047 Tyrosine kinase, catalytic domain 2048 Tyrosine kinase, catalytic domain 2048 Tyrosine kinase, catalytic domain 2049 Tyrosine kinase, catalytic domain 2049 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 2050 Fibronectin type 3 domain 2050 Tyrosine kinase, catalytic domain 2050 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 2051 Tyrosine kinase, catalytic domain 2055 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 2057 Fibronectin type 3 domain 2059 Src homology 3 domains 2059 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 2060 Eps15 homology domain 2064 Tyrosine kinase, catalytic domain 2065 Furin-like repeats 2065 Tyrosine kinase, catalytic domain 2066 Tyrosine kinase, catalytic domain 2068 DEAD-like helicases superfamily 2081 Serine/Threonine protein kinases, catalytic domain 2081 domain in protein kinases, N-glycanases and other nuclear proteins 2101 Ligand binding domain of hormone receptors 2114 SAM / Pointed domain 2120 SAM / Pointed domain 2125 Plectin repeat 2130 RNA recognition motif 2130 RNA recognition motif 2147 Kringle domain 2147 Trypsin-like serine protease 2147 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 2155 Trypsin-like serine protease 2155 Calcium-binding EGF-like domain 2155 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 2155 Trypsin-like serine protease 2155 Calcium-binding EGF-like domain 2155 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 2158 Trypsin-like serine protease 2158 Calcium-binding EGF-like domain 2158 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 2159 Trypsin-like serine protease 2159 Calcium-binding EGF-like domain 2159 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 2160 APPLE domain 2160 Trypsin-like serine protease 2160 APPLE domain 2160 Trypsin-like serine protease 2161 Fibronectin type 2 domain 2161 Trypsin-like serine protease 2165 Domain abundant in complement control proteins 2165 Domain abundant in complement control proteins 2185 Band 4.1 homologues 2185 Tyrosine kinase, catalytic domain 2185 Band 4.1 homologues 2185 Tyrosine kinase, catalytic domain 2185 Band 4.1 homologues 2185 Tyrosine kinase, catalytic domain 2185 Band 4.1 homologues 2185 Tyrosine kinase, catalytic domain 2186 bromo domain 2186 bromo domain 2186 bromo domain 2186 PHD zinc finger 2192 Calcium-binding EGF-like domain 2192 Calcium-binding EGF-like domain 2195 Laminin G domain 2195 Calcium-binding EGF-like domain 2195 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 2196 Laminin G domain 2196 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 2197 Ubiquitin homologues 2199 Calcium-binding EGF-like domain 2202 Calcium-binding EGF-like domain 2202 Calcium-binding EGF-like domain 2205 Immunoglobulin 2205 Immunoglobulin C-2 Type 2209 Immunoglobulin 2209 Immunoglobulin C-2 Type 2212 Immunoglobulin 2212 Immunoglobulin C-2 Type 2213 Immunoglobulin 2213 Immunoglobulin C-2 Type 2214 Immunoglobulin 2215 Immunoglobulin 2217 Immunoglobulin C-Type 2219 Fibrinogen-related domains (FReDs) 2220 Fibrinogen-related domains (FReDs) 2220 Fibrinogen-related domains (FReDs) 2220 Fibrinogen-related domains (FReDs) 2241 Tyrosine kinase, catalytic domain 2242 Tyrosine kinase, catalytic domain 2243 Fibrinogen-related domains (FReDs) 2245 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 2255 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2256 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2257 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2257 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2258 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2258 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2259 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2259 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 2260 Immunoglobulin 2260 Immunoglobulin C-2 Type 2260 Tyrosine kinase, catalytic domain 2260 Immunoglobulin 2260 Immunoglobulin C-2 Type 2260 Tyrosine kinase, catalytic domain 2260 Immunoglobulin 2260 Tyrosine kinase, catalytic domain 2260 Immunoglobulin 2260 Tyrosine kinase, catalytic domain 2260 Immunoglobulin 2260 Immunoglobulin 2260 Immunoglobulin 2260 Immunoglobulin C-2 Type 2260 Tyrosine kinase, catalytic domain 2260 Immunoglobulin C-2 Type 2260 Immunoglobulin 2260 Immunoglobulin C-2 Type 2260 Tyrosine kinase, catalytic domain 2261 Immunoglobulin 2261 Immunoglobulin C-2 Type 2261 Tyrosine kinase, catalytic domain 2261 Immunoglobulin 2261 Immunoglobulin C-2 Type 2261 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Immunoglobulin 2263 Immunoglobulin C-2 Type 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Tyrosine kinase, catalytic domain 2263 Immunoglobulin 2263 Tyrosine kinase, catalytic domain 2264 Immunoglobulin 2264 Immunoglobulin C-2 Type 2264 Tyrosine kinase, catalytic domain 2264 Immunoglobulin 2264 Immunoglobulin C-2 Type 2264 Tyrosine kinase, catalytic domain 2267 Fibrinogen-related domains (FReDs) 2267 Fibrinogen-related domains (FReDs) 2268 Tyrosine kinase, catalytic domain 2273 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 2274 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 2275 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 2277 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 2294 FORKHEAD 2295 FORKHEAD 2299 FORKHEAD 2299 FORKHEAD 2300 FORKHEAD 2304 FORKHEAD 2305 FORKHEAD 2307 FORKHEAD 2308 FORKHEAD 2309 FORKHEAD 2313 SAM / Pointed domain 2314 Gelsolin homology domain 2316 Filamin-type immunoglobulin domains 2317 Filamin-type immunoglobulin domains 2318 Filamin-type immunoglobulin domains 2321 Immunoglobulin 2321 Immunoglobulin C-2 Type 2321 Tyrosine kinase, catalytic domain 2322 Tyrosine kinase, catalytic domain 2324 Immunoglobulin 2324 Immunoglobulin C-2 Type 2324 Tyrosine kinase, catalytic domain 2332 K homology RNA-binding domain 2335 Fibronectin type 1 domain 2335 Fibronectin type 1 domain 2335 Fibronectin type 2 domain 2335 Fibronectin type 1 domain 2335 Fibronectin type 2 domain 2353 basic region leucin zipper 2444 Src homology 2 domains 2444 Src homology 3 domains 2444 Tyrosine kinase, catalytic domain 2487 Frizzled 2488 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 2515 ADAM Cysteine-Rich Domain 2515 Homologues of snake disintegrins 2520 gastrin / cholecystokinin / caerulein family 2530 Src homology 3 domains 2530 Src homology 3 domains 2530 Src homology 3 domains 2530 Src homology 3 domains 2530 Src homology 3 domains 2533 Src homology 3 domains 2534 Tyrosine kinase, catalytic domain 2534 Tyrosine kinase, catalytic domain 2534 Tyrosine kinase, catalytic domain 2535 Frizzled 2538 Acid phosphatase homologues 2548 P or trefoil or TFF domain 2549 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 2550 Domain abundant in complement control proteins 2550 Domain abundant in complement control proteins 2580 DnaJ molecular chaperone homology domain 2580 Serine/Threonine protein kinases, catalytic domain 2589 Ricin-type beta-trefoil 2590 Ricin-type beta-trefoil 2591 Ricin-type beta-trefoil 2596 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 2620 Calponin homology domain 2620 Calponin homology domain 2621 Laminin G domain 2621 Calcium-binding EGF-like domain 2621 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 2623 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 2625 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 2626 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 2627 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 2638 serum albumin 2641 Glucagon like hormones 2657 Transforming growth factor-beta (TGF-beta) family 2658 Transforming growth factor-beta (TGF-beta) family 2660 Transforming growth factor-beta (TGF-beta) family 2661 Transforming growth factor-beta (TGF-beta) family 2662 Transforming growth factor-beta (TGF-beta) family 2669 Ras subfamily of RAS small GTPases 2669 Ras subfamily of RAS small GTPases 2692 Domain present in hormone receptors 2696 Domain present in hormone receptors 2703 Connexin homologues 2740 Domain present in hormone receptors 2765 Ly-6 antigen / uPA receptor -like domain 2785 G protein gamma subunit-like motifs 2786 G protein gamma subunit-like motifs 2787 G protein gamma subunit-like motifs 2788 G protein gamma subunit-like motifs 2791 G protein gamma subunit-like motifs 2792 G protein gamma subunit-like motifs 2793 G protein gamma subunit-like motifs 2810 14-3-3 homologues 2811 Leucine rich repeat C-terminal domain 2812 Leucine rich repeat C-terminal domain 2822 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 2868 Serine/Threonine protein kinases, catalytic domain 2869 Serine/Threonine protein kinases, catalytic domain 2870 Serine/Threonine protein kinases, catalytic domain 2872 Serine/Threonine protein kinases, catalytic domain 2874 domain in neuralized proteins 2885 Src homology 3 domains 2886 Src homology 2 domains 2886 Ras association (RalGDS/AF-6) domain 2886 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 2887 Src homology 2 domains 2887 Ras association (RalGDS/AF-6) domain 2887 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 2888 Src homology 2 domains 2888 Ras association (RalGDS/AF-6) domain 2888 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 2889 Guanine nucleotide exchange factor for Ras-like GTPases 2889 Guanine nucleotide exchange factor for Ras-like small GTPases 2890 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2891 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2892 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2892 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2893 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2894 Bacterial periplasmic substrate-binding proteins 2894 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2895 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2896 Granulin 2897 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2897 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2898 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2898 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2899 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2900 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2901 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2902 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2902 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2902 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2903 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2904 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2905 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2906 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 2909 Contains two conserved F residues 2909 GTPase-activator protein for Rho-like GTPases 2909 Contains two conserved F residues 2909 GTPase-activator protein for Rho-like GTPases 2926 RNA recognition motif 2931 Serine/Threonine protein kinases, catalytic domain 2932 Serine/Threonine protein kinases, catalytic domain 2934 Gelsolin homology domain 2974 Adenylyl- / guanylyl cyclase, catalytic domain 2976 WD40 repeats 2982 Adenylyl- / guanylyl cyclase, catalytic domain 2984 Tyrosine kinase, catalytic domain 2984 Adenylyl- / guanylyl cyclase, catalytic domain 2986 Tyrosine kinase, catalytic domain 2986 Adenylyl- / guanylyl cyclase, catalytic domain 2987 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 2995 putative band 4.1 homologues' binding motif 2995 putative band 4.1 homologues' binding motif 2999 Trypsin-like serine protease 3000 Adenylyl- / guanylyl cyclase, catalytic domain 3001 Trypsin-like serine protease 3002 Trypsin-like serine protease 3003 Trypsin-like serine protease 3004 Trypsin-like serine protease 3012 Histone 2A 3013 Histone 2A 3014 Histone 2A 3015 Histone 2A 3017 Histone H2B 3017 Histone H2B 3018 Histone H2B 3020 Histone H3 3021 Histone H3 3026 Kringle domain 3026 Trypsin-like serine protease 3055 Tyrosine kinase, catalytic domain 3059 Src homology 3 domains 3069 K homology RNA-binding domain 3075 Domain abundant in complement control proteins 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3077 Immunoglobulin C-Type 3078 Domain abundant in complement control proteins 3080 Domain abundant in complement control proteins 3082 Kringle domain 3082 Trypsin-like serine protease 3082 divergent subfamily of APPLE domains 3083 Fibronectin type 2 domain 3083 Trypsin-like serine protease 3084 Immunoglobulin 3084 Immunoglobulin 3084 Immunoglobulin 3084 Immunoglobulin 3084 Immunoglobulin 3084 Immunoglobulin 3084 Immunoglobulin 3084 Immunoglobulin 3091 PAS domain 3091 PAS domain 3092 I/LWEQ domain 3093 Ubiquitin associated domain 3093 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 3105 Immunoglobulin C-Type 3106 Immunoglobulin C-Type 3107 Immunoglobulin C-Type 3108 Immunoglobulin C-Type 3109 Immunoglobulin C-Type 3111 Immunoglobulin C-Type 3112 Immunoglobulin C-Type 3113 Immunoglobulin C-Type 3115 Immunoglobulin C-Type 3117 Immunoglobulin C-Type 3118 Immunoglobulin C-Type 3119 Immunoglobulin C-Type 3120 Immunoglobulin C-Type 3120 Immunoglobulin C-Type 3122 Immunoglobulin C-Type 3123 Immunoglobulin C-Type 3125 Immunoglobulin C-Type 3126 Immunoglobulin C-Type 3127 Immunoglobulin C-Type 3131 basic region leucin zipper 3133 Immunoglobulin C-Type 3134 Immunoglobulin C-Type 3135 Immunoglobulin C-Type 3140 Immunoglobulin C-Type 3175 Homeodomain 3178 RNA recognition motif 3178 RNA recognition motif 3181 RNA recognition motif 3181 RNA recognition motif 3182 RNA recognition motif 3182 RNA recognition motif 3183 RNA recognition motif 3183 RNA recognition motif 3184 RNA recognition motif 3184 RNA recognition motif 3184 RNA recognition motif 3185 RNA recognition motif 3185 RNA recognition motif 3187 RNA recognition motif 3188 RNA recognition motif 3189 RNA recognition motif 3189 RNA recognition motif 3190 K homology RNA-binding domain 3190 K homology RNA-binding domain 3190 K homology RNA-binding domain 3191 RNA recognition motif 3240 Trypsin-like serine protease 3249 Trypsin-like serine protease 3250 Trypsin-like serine protease 3263 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 3265 Ras subfamily of RAS small GTPases 3266 Ras subfamily of RAS small GTPases 3266 Rab subfamily of small GTPases 3266 Ras subfamily of RAS small GTPases 3266 Rho (Ras homology) subfamily of Ras-like small GTPases 3267 Putative GTP-ase activating proteins for the small GTPase, ARF 3268 Putative GTP-ase activating proteins for the small GTPase, ARF 3273 Cystatin-like domain 3275 Src homology 3 domains 3280 Orange domain 3321 Immunoglobulin V-Type 3324 Histidine kinase-like ATPases 3339 Immunoglobulin 3339 Laminin B domain 3339 Laminin G domain 3339 Immunoglobulin C-2 Type 3339 Laminin-type epidermal growth factor-like domai 3339 Low-density lipoprotein receptor domain class A 3339 Domain found in sea urchin sperm protein, enterokinase, agrin 3371 Fibrinogen-related domains (FReDs) 3375 calcitonin 3383 Immunoglobulin 3397 helix loop helix domain 3397 helix loop helix domain 3399 helix loop helix domain 3426 Trypsin-like serine protease 3426 factor I membrane attack complex 3431 bromo domain 3431 bromo domain 3441 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3442 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3443 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3447 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3451 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3456 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3467 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 3479 Insulin / insulin-like growth factor / relaxin family. 3480 Tyrosine kinase, catalytic domain 3482 Fibronectin type 2 domain 3483 Leucine rich repeat C-terminal domain 3484 Insulin growth factor-binding protein homologues 3486 Thyroglobulin type I repeats. 3486 Insulin growth factor-binding protein homologues 3487 Insulin growth factor-binding protein homologues 3490 Immunoglobulin 3490 Kazal type serine protease inhibitors 3491 von Willebrand factor (vWF) type C domain 3491 Insulin growth factor-binding protein homologues 3508 AN1-like Zinc finger 3508 Putative single-stranded nucleic acids-binding domain 3543 Immunoglobulin C-Type 3547 Immunoglobulin 3549 Hint (Hedgehog/Intein) domain C-terminal region 3549 Hint (Hedgehog/Intein) domain N-terminal region 3551 Tyrosine kinase, catalytic domain 3551 Serine/Threonine protein kinases, catalytic domain 3552 Interleukin-1 homologues 3553 Interleukin-1 homologues 3554 Immunoglobulin 3554 Immunoglobulin C-2 Type 3557 Interleukin-1 homologues 3557 Interleukin-1 homologues 3557 Interleukin-1 homologues 3557 Interleukin-1 homologues 3558 Interleukin-2 family 3560 Fibronectin type 3 domain 3565 Interleukins 4 and 13 3565 Interleukins 4 and 13 3570 Immunoglobulin C-2 Type 3570 Fibronectin type 3 domain 3570 Immunoglobulin C-2 Type 3570 Fibronectin type 3 domain 3572 Fibronectin type 3 domain 3574 Interleukin-7 and interleukin-9 family. IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its functio 3586 Interleukin-10 family 3590 Immunoglobulin 3590 Immunoglobulin 3593 Immunoglobulin C-2 Type 3596 Interleukins 4 and 13 3603 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 3603 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 3607 Forkhead associated domain 3607 FORKHEAD 3607 Forkhead associated domain 3608 domain in DSRM or ZnF_C2H2 domain containing proteins 3609 Double-stranded RNA binding motif 3609 domain in DSRM or ZnF_C2H2 domain containing proteins 3609 Double-stranded RNA binding motif 3609 domain in DSRM or ZnF_C2H2 domain containing proteins 3609 Double-stranded RNA binding motif 3609 domain in DSRM or ZnF_C2H2 domain containing proteins 3623 Transforming growth factor-beta (TGF-beta) family 3624 Transforming growth factor-beta (TGF-beta) family 3625 Transforming growth factor-beta (TGF-beta) family 3626 Transforming growth factor-beta (TGF-beta) family 3632 Inositol polyphosphate phosphatase, catalytic domain homologues 3633 Major prion protein 3635 Src homology 2 domains 3635 Inositol polyphosphate phosphatase, catalytic domain homologues 3636 Src homology 2 domains 3636 Inositol polyphosphate phosphatase, catalytic domain homologues 3636 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 3640 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 3643 Tyrosine kinase, catalytic domain 3645 Tyrosine kinase, catalytic domain 3645 Furin-like repeats 3645 Fibronectin type 3 domain 3652 Kelch domain 3655 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3661 interferon regulatory factor 3662 Domain B in dwarfin family proteins 3663 interferon regulatory factor 3663 interferon regulatory factor 3664 interferon regulatory factor 3665 interferon regulatory factor 3665 Domain B in dwarfin family proteins 3665 interferon regulatory factor 3665 Domain B in dwarfin family proteins 3665 interferon regulatory factor 3665 interferon regulatory factor 3667 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 3669 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 3670 Homeodomain 3671 Immunoglobulin 3672 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3673 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3674 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3675 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3675 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3676 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3678 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3679 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3680 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3681 von Willebrand factor (vWF) type A domain 3682 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3683 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3684 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3685 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 3692 translation initiation factor 6 3692 translation initiation factor 6 3697 Vault protein Inter-alpha-Trypsin domain 3698 Vault protein Inter-alpha-Trypsin domain 3698 von Willebrand factor (vWF) type A domain 3699 Vault protein Inter-alpha-Trypsin domain 3699 von Willebrand factor (vWF) type A domain 3700 Vault protein Inter-alpha-Trypsin domain 3700 von Willebrand factor (vWF) type A domain 3702 Tyrosine kinase, catalytic domain 3702 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 3708 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 3709 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 3714 von Willebrand factor (vWF) type C domain 3714 von Willebrand factor (vWF) type C domain 3716 Band 4.1 homologues 3716 Src homology 2 domains 3716 Tyrosine kinase, catalytic domain 3717 Band 4.1 homologues 3717 Src homology 2 domains 3717 Tyrosine kinase, catalytic domain 3718 Band 4.1 homologues 3718 Src homology 2 domains 3718 Tyrosine kinase, catalytic domain 3730 Four-disulfide core domains 3757 Cyclic nucleotide-monophosphate binding domain 3757 Cyclic nucleotide-monophosphate binding domain 3757 Cyclic nucleotide-monophosphate binding domain 3788 Broad-Complex, Tramtrack and Bric a brac 3791 Immunoglobulin 3791 Immunoglobulin C-2 Type 3791 Tyrosine kinase, catalytic domain 3796 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 3805 Immunoglobulin 3811 Immunoglobulin 3813 Immunoglobulin 3815 Immunoglobulin 3815 Tyrosine kinase, catalytic domain 3816 Trypsin-like serine protease 3817 Trypsin-like serine protease 3818 APPLE domain 3818 Trypsin-like serine protease 3820 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3821 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3821 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3822 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3823 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3823 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3824 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3824 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 3832 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 3833 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 3834 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 3834 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 3835 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 3845 Ras subfamily of RAS small GTPases 3845 Ras subfamily of RAS small GTPases 3897 Immunoglobulin 3897 Immunoglobulin C-2 Type 3897 Immunoglobulin 3897 Immunoglobulin C-2 Type 3902 Immunoglobulin 3908 Laminin B domain 3908 Laminin G domain 3908 Laminin-type epidermal growth factor-like domai 3909 Laminin G domain 3909 Laminin-type epidermal growth factor-like domai 3910 Laminin G domain 3910 Laminin-type epidermal growth factor-like domai 3911 Laminin B domain 3911 Laminin G domain 3911 Laminin N-terminal domain (domain VI) 3911 Laminin-type epidermal growth factor-like domai 3912 Laminin-type epidermal growth factor-like domai 3913 Laminin-type epidermal growth factor-like domai 3914 Laminin N-terminal domain (domain VI) 3914 Laminin-type epidermal growth factor-like domai 3915 Laminin-type epidermal growth factor-like domai 3918 Laminin B domain 3918 Laminin-type epidermal growth factor-like domai 3918 Laminin B domain 3918 Laminin-type epidermal growth factor-like domai 3927 Src homology 3 domains 3927 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 3930 Tudor domain 3932 Src homology 3 domains 3932 Tyrosine kinase, catalytic domain 3936 Calponin homology domain 3937 Src homology 2 domains 3937 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 3949 Calcium-binding EGF-like domain 3953 Fibronectin type 3 domain 3959 Scavenger receptor Cys-rich 3960 Galectin 3963 Galectin 3964 Galectin 3965 Galectin 3965 Galectin 3972 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 3976 leukemia inhibitory factor 3977 Fibronectin type 3 domain 3983 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 3983 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 3983 Villin headpiece domain 3984 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 3984 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 3985 Tyrosine kinase, catalytic domain 3985 Tyrosine kinase, catalytic domain 3990 Lipoxygenase homology 2 (beta barrel) domain 4007 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 4008 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 4008 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 4013 von Willebrand factor (vWF) type A domain 4017 Scavenger receptor Cys-rich 4018 Trypsin-like serine protease 4026 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 4034 Calponin homology domain 4035 Low-density lipoprotein-receptor YWTD domain 4035 Low-density lipoprotein receptor domain class A 4036 Low-density lipoprotein-receptor YWTD domain 4036 Low-density lipoprotein receptor domain class A 4037 Low-density lipoprotein receptor domain class A 4037 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 4038 Calcium-binding EGF-like domain 4038 Epidermal growth factor-like domain 4038 Low-density lipoprotein-receptor YWTD domain 4040 Low-density lipoprotein-receptor YWTD domain 4040 Low-density lipoprotein receptor domain class A 4041 Low-density lipoprotein-receptor YWTD domain 4041 Low-density lipoprotein receptor domain class A 4045 Immunoglobulin 4045 Immunoglobulin C-2 Type 4049 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 4052 Calcium-binding EGF-like domain 4053 Calcium-binding EGF-like domain 4054 Calcium-binding EGF-like domain 4057 Transferrin 4058 Tyrosine kinase, catalytic domain 4059 Immunoglobulin 4059 Immunoglobulin C-2 Type 4065 Ricin-type beta-trefoil 4065 Fibronectin type 2 domain 4065 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 4066 helix loop helix domain 4067 Tyrosine kinase, catalytic domain 4068 Src homology 2 domains 4069 Alpha-lactalbumin / lysozyme C 4077 PB1 domain 4077 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 4077 PB1 domain 4077 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 4077 PB1 domain 4077 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 4091 Domain A in dwarfin family proteins 4091 Domain B in dwarfin family proteins 4099 Immunoglobulin 4099 Immunoglobulin 4099 Immunoglobulin C-2 Type 4117 Serine/Threonine protein kinases, catalytic domain 4139 Serine/Threonine protein kinases, catalytic domain 4140 Serine/Threonine protein kinases, catalytic domain 4145 Src homology 2 domains 4145 Src homology 3 domains 4145 Tyrosine kinase, catalytic domain 4145 Src homology 2 domains 4145 Src homology 3 domains 4145 Tyrosine kinase, catalytic domain 4145 Src homology 2 domains 4145 Src homology 3 domains 4145 Tyrosine kinase, catalytic domain 4146 Epidermal growth factor-like domain 4154 zinc finger 4162 Immunoglobulin 4168 Spectrin repeats 4168 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 4168 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 4171 minichromosome maintenance proteins 4172 minichromosome maintenance proteins 4173 minichromosome maintenance proteins 4173 minichromosome maintenance proteins 4173 minichromosome maintenance proteins 4174 minichromosome maintenance proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4179 Domain abundant in complement control proteins 4185 ADAM Cysteine-Rich Domain 4185 Homologues of snake disintegrins 4185 ADAM Cysteine-Rich Domain 4185 Homologues of snake disintegrins 4197 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 4204 Methyl-CpG binding domain 4210 associated with SPRY domains 4210 Domain in SPla and the RYanodine Receptor. 4211 Homeodomain 4212 Homeodomain 4212 Homeodomain 4212 Homeodomain 4212 Homeodomain 4212 Homeodomain 4212 Homeodomain 4212 Homeodomain 4214 Tyrosine kinase, catalytic domain 4214 Serine/Threonine protein kinases, catalytic domain 4215 PB1 domain 4215 Serine/Threonine protein kinases, catalytic domain 4216 Serine/Threonine protein kinases, catalytic domain 4216 Serine/Threonine protein kinases, catalytic domain 4217 Serine/Threonine protein kinases, catalytic domain 4233 Tyrosine kinase, catalytic domain 4233 ig-like, plexins, transcription factors 4238 Immunoglobulin C-2 Type 4239 Fibrinogen-related domains (FReDs) 4241 Transferrin 4256 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 4276 Immunoglobulin C-Type 4277 Immunoglobulin C-Type 4281 Ring finger 4281 B-Box-type zinc finger 4281 B-Box C-terminal domain 4281 Fibronectin type 3 domain 4281 associated with SPRY domains 4281 Domain in SPla and the RYanodine Receptor. 4281 Ring finger 4281 B-Box-type zinc finger 4281 B-Box C-terminal domain 4281 Fibronectin type 3 domain 4281 associated with SPRY domains 4281 Domain in SPla and the RYanodine Receptor. 4281 Ring finger 4281 B-Box-type zinc finger 4281 B-Box C-terminal domain 4281 Fibronectin type 3 domain 4281 associated with SPRY domains 4293 Tyrosine kinase, catalytic domain 4293 Serine/Threonine protein kinases, catalytic domain 4294 Src homology 3 domains 4294 Tyrosine kinase, catalytic domain 4296 Src homology 3 domains 4296 Tyrosine kinase, catalytic domain 4297 bromo domain 4297 PHD zinc finger 4297 "FY-rich" domain, C-terminal region 4297 "FY-rich" domain, N-terminal region 4301 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 4303 FORKHEAD 4312 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4313 Fibronectin type 2 domain 4313 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4314 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4317 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4318 Fibronectin type 2 domain 4318 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4319 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4321 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4322 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4326 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4327 Zinc-dependent metalloprotease 4327 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4327 Zinc-dependent metalloprotease 4327 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 4340 Immunoglobulin V-Type 4345 Immunoglobulin V-Type 4354 Src homology 3 domains 4354 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 4355 Src homology 3 domains 4355 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 4355 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 4356 Src homology 3 domains 4356 domain in receptor targeting proteins Lin-2 and Lin-7 4356 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 4356 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 4359 Immunoglobulin V-Type 4360 Ricin-type beta-trefoil 4360 Fibronectin type 2 domain 4360 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 4430 Myosin. Large ATPases. ATPase 4481 Scavenger receptor Cys-rich 4481 Scavenger receptor Cys-rich 4485 Kringle domain 4485 Trypsin-like serine protease 4485 divergent subfamily of APPLE domains 4486 Tyrosine kinase, catalytic domain 4486 ig-like, plexins, transcription factors 4534 Protein tyrosine phosphatase, catalytic domain motif 4542 Src homology 3 domains 4542 Myosin. Large ATPases. ATPase 4583 von Willebrand factor (vWF) type D domain 4583 C-terminal cystine knot-like domain (CTCK) 4583 C-terminal cystine knot-like domain (CTCK) 4583 von Willebrand factor (vWF) type D domain 4585 von Willebrand factor (vWF) type D domain 4585 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 4585 von Willebrand factor (vWF) type D domain 4585 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 4585 von Willebrand factor (vWF) type D domain 4585 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 4585 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 4585 von Willebrand factor (vWF) type D domain 4585 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 4587 C-terminal cystine knot-like domain (CTCK) 4587 von Willebrand factor (vWF) type D domain 4588 C-terminal cystine knot-like domain (CTCK) 4591 Ring finger 4591 B-Box C-terminal domain 4591 meprin and TRAF homology 4593 Immunoglobulin 4593 Immunoglobulin C-2 Type 4593 Tyrosine kinase, catalytic domain 4599 Dynamin GTPase effector domain 4601 helix loop helix domain 4601 helix loop helix domain 4603 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 4604 Immunoglobulin 4604 Fibronectin type 3 domain 4606 Immunoglobulin 4606 Fibronectin type 3 domain 4607 Immunoglobulin 4607 Fibronectin type 3 domain 4608 Immunoglobulin 4608 Fibronectin type 3 domain 4611 helix loop helix domain 4615 Toll - interleukin 1 - resistance 4628 Myosin. Large ATPases. ATPase 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Serine/Threonine protein kinases, catalytic domain 4638 Immunoglobulin 4638 Immunoglobulin 4640 Myosin. Large ATPases. ATPase 4641 Myosin. Large ATPases. ATPase 4642 Myosin. Large ATPases. ATPase 4643 Src homology 3 domains 4643 Myosin. Large ATPases. ATPase 4646 Myosin. Large ATPases. ATPase 4647 Band 4.1 homologues 4647 Myosin. Large ATPases. ATPase 4647 Domain in Myosin and Kinesin Tails 4648 Band 4.1 homologues 4648 Src homology 3 domains 4648 Domain in Myosin and Kinesin Tails 4649 Myosin. Large ATPases. ATPase 4649 Ras association (RalGDS/AF-6) domain 4649 GTPase-activator protein for Rho-like GTPases 4650 Myosin. Large ATPases. ATPase 4650 GTPase-activator protein for Rho-like GTPases 4650 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 4651 Band 4.1 homologues 4651 Myosin. Large ATPases. ATPase 4651 Domain in Myosin and Kinesin Tails 4651 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 4653 Olfactomedin-like domains 4670 RNA recognition motif 4670 RNA recognition motif 4671 Baculoviral inhibition of apoptosis protein repeat 4680 Immunoglobulin 4684 Immunoglobulin 4684 Immunoglobulin C-2 Type 4685 Immunoglobulin 4685 Immunoglobulin C-2 Type 4685 Fibronectin type 3 domain 4686 Middle domain of eukaryotic initiation factor 4G (eIF4G) 4687 Src homology 3 domains 4687 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 4688 PB1 domain 4688 Src homology 3 domains 4688 Tetratricopeptide repeats 4689 PB1 domain 4689 Src homology 3 domains 4689 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 4689 Src homology 3 domains 4689 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 4690 Src homology 2 domains 4690 Src homology 3 domains 4691 RNA recognition motif 4693 C-terminal cystine knot-like domain (CTCK) 4703 Src homology 3 domains 4703 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 4734 Domain with 2 conserved Trp (W) residues 4734 Protein kinase C conserved region 2 (CalB) 4734 Domain Homologous to E6-AP Carboxyl Terminus with 4739 Src homology 3 domains 4745 Calcium-binding EGF-like domain 4745 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 4750 Tyrosine kinase, catalytic domain 4750 Serine/Threonine protein kinases, catalytic domain 4751 Serine/Threonine protein kinases, catalytic domain 4752 Serine/Threonine protein kinases, catalytic domain 4752 Serine/Threonine protein kinases, catalytic domain 4753 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 4756 Immunoglobulin 4756 Immunoglobulin C-2 Type 4756 Fibronectin type 3 domain 4763 GTPase-activator protein for Ras-like GTPases 4763 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 4772 ig-like, plexins, transcription factors 4772 ig-like, plexins, transcription factors 4772 ig-like, plexins, transcription factors 4772 ig-like, plexins, transcription factors 4772 ig-like, plexins, transcription factors 4773 ig-like, plexins, transcription factors 4773 ig-like, plexins, transcription factors 4774 Domain A in dwarfin family proteins 4775 ig-like, plexins, transcription factors 4775 ig-like, plexins, transcription factors 4775 ig-like, plexins, transcription factors 4775 ig-like, plexins, transcription factors 4776 ig-like, plexins, transcription factors 4779 basic region leucin zipper 4780 basic region leucin zipper 4783 basic region leucin zipper 4790 ig-like, plexins, transcription factors 4790 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 4791 ig-like, plexins, transcription factors 4799 Putative single-stranded nucleic acids-binding domain 4800 CCAAT-Binding transcription Factor 4800 CCAAT-Binding transcription Factor 4804 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 4807 helix loop helix domain 4811 G2 nidogen domain and fibulin 4811 Calcium-binding EGF-like domain 4811 Low-density lipoprotein-receptor YWTD domain 4811 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 4838 Transforming growth factor-beta (TGF-beta) family 4841 RNA recognition motif 4851 Calcium-binding EGF-like domain 4851 Domain found in Notch and Lin-12 4853 Calcium-binding EGF-like domain 4853 Domain found in Notch and Lin-12 4854 Calcium-binding EGF-like domain 4854 Domain found in Notch and Lin-12 4855 Calcium-binding EGF-like domain 4855 Domain found in Notch and Lin-12 4856 von Willebrand factor (vWF) type C domain 4856 C-terminal cystine knot-like domain (CTCK) 4856 Insulin growth factor-binding protein homologues 4857 K homology RNA-binding domain 4857 K homology RNA-binding domain 4857 K homology RNA-binding domain 4858 K homology RNA-binding domain 4861 PAS domain 4861 helix loop helix domain 4862 PAS domain 4862 helix loop helix domain 4862 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 4867 Src homology 3 domains 4868 Immunoglobulin 4868 Immunoglobulin C-2 Type 4881 Adenylyl- / guanylyl cyclase, catalytic domain 4882 Adenylyl- / guanylyl cyclase, catalytic domain 4882 Adenylyl- / guanylyl cyclase, catalytic domain 4884 Pentraxin / C-reactive protein / pentaxin family 4885 Pentraxin / C-reactive protein / pentaxin family 4892 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 4892 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 4893 Ras subfamily of RAS small GTPases 4897 Immunoglobulin 4897 Immunoglobulin C-2 Type 4914 Immunoglobulin 4914 Tyrosine kinase, catalytic domain 4915 Immunoglobulin 4915 Tyrosine kinase, catalytic domain 4916 Immunoglobulin 4916 Immunoglobulin C-2 Type 4916 Tyrosine kinase, catalytic domain 4917 Laminin N-terminal domain (domain VI) 4919 Immunoglobulin 4919 Kringle domain 4919 Tyrosine kinase, catalytic domain 4920 Immunoglobulin 4920 Kringle domain 4920 Tyrosine kinase, catalytic domain 4921 Tyrosine kinase, catalytic domain 4943 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 4952 Inositol polyphosphate phosphatase, catalytic domain homologues 4952 Inositol polyphosphate phosphatase, catalytic domain homologues 4958 Leucine rich repeat N-terminal domain 4973 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 4978 Immunoglobulin 4978 Immunoglobulin C-2 Type 4982 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 4982 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 4982 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 4983 GTPase-activator protein for Rho-like GTPases 4983 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 4990 Homeodomain 4998 Bromo adjacent homology domain 5007 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5008 leukemia inhibitory factor 5016 Glyco_18 domain 5033 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 5046 Furin-like repeats 5046 Furin-like repeats 5048 Lissencephaly type-1-like homology motif 5055 SERine Proteinase INhibitors 5058 Serine/Threonine protein kinases, catalytic domain 5062 Serine/Threonine protein kinases, catalytic domain 5063 Serine/Threonine protein kinases, catalytic domain 5067 Immunoglobulin 5067 Immunoglobulin C-2 Type 5067 Fibronectin type 3 domain 5069 LamG-like jellyroll fold domain 5069 Domain found in Notch and Lin-12 5069 Domain abundant in complement control proteins 5076 Paired Box domain 5076 Paired Box domain 5076 Paired Box domain 5078 Paired Box domain 5081 Homeodomain 5081 Homeodomain 5093 K homology RNA-binding domain 5094 K homology RNA-binding domain 5094 K homology RNA-binding domain 5097 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5097 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5098 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5098 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5099 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5099 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5099 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5100 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5100 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5101 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 5118 Netrin C-terminal Domain 5118 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 5127 Serine/Threonine protein kinases, catalytic domain 5127 Serine/Threonine protein kinases, catalytic domain 5127 Serine/Threonine protein kinases, catalytic domain 5128 Serine/Threonine protein kinases, catalytic domain 5129 Tyrosine kinase, catalytic domain 5129 Serine/Threonine protein kinases, catalytic domain 5133 Immunoglobulin V-Type 5138 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 5145 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 5146 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 5156 Immunoglobulin 5156 Tyrosine kinase, catalytic domain 5157 Immunoglobulin 5158 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 5159 Immunoglobulin 5159 Tyrosine kinase, catalytic domain 5167 Somatomedin B -like domains 5167 DNA/RNA non-specific endonuclease 5168 DNA/RNA non-specific endonuclease 5169 DNA/RNA non-specific endonuclease 5170 Serine/Threonine protein kinases, catalytic domain 5174 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5175 Immunoglobulin 5176 SERine Proteinase INhibitors 5178 leucine rich region 5187 PAS domain 5193 Ring finger 5194 Src homology 3 domains 5196 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 5199 Thrombospondin type 1 repeats 5216 Profilin 5217 Profilin 5218 Serine/Threonine protein kinases, catalytic domain 5228 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 5260 Serine/Threonine protein kinases, catalytic domain 5261 Serine/Threonine protein kinases, catalytic domain 5266 Four-disulfide core domains 5267 SERine Proteinase INhibitors 5271 SERine Proteinase INhibitors 5272 SERine Proteinase INhibitors 5273 SERine Proteinase INhibitors 5274 SERine Proteinase INhibitors 5276 SERine Proteinase INhibitors 5284 Immunoglobulin 5286 Protein kinase C conserved region 2 (CalB) 5286 Phosphoinositide 3-kinase, catalytic domain 5286 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 5286 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 5287 Protein kinase C conserved region 2 (CalB) 5287 Phosphoinositide 3-kinase, catalytic domain 5287 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 5287 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 5288 Protein kinase C conserved region 2 (CalB) 5288 Phosphoinositide 3-kinase, catalytic domain 5288 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 5288 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 5289 Phosphoinositide 3-kinase, catalytic domain 5289 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 5290 PI3-kinase family, Ras-binding domain 5290 PI3-kinase family, p85-binding domain 5290 Phosphoinositide 3-kinase, catalytic domain 5291 PI3-kinase family, p85-binding domain 5291 Phosphoinositide 3-kinase, catalytic domain 5293 PI3-kinase family, p85-binding domain 5293 Phosphoinositide 3-kinase, catalytic domain 5294 PI3-kinase family, Ras-binding domain 5294 Phosphoinositide 3-kinase, catalytic domain 5295 Src homology 2 domains 5295 Src homology 2 domains 5295 Src homology 3 domains 5295 Src homology 2 domains 5295 Src homology 2 domains 5295 Src homology 3 domains 5295 GTPase-activator protein for Rho-like GTPases 5296 Src homology 2 domains 5296 Src homology 3 domains 5297 Phosphoinositide 3-kinase, catalytic domain 5297 Phosphoinositide 3-kinase, catalytic domain 5298 Phosphoinositide 3-kinase, catalytic domain 5310 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 5310 present in yeast cell wall integrity and stress response component proteins 5314 ig-like, plexins, transcription factors 5314 ig-like, plexins, transcription factors 5316 Homeodomain 5317 Armadillo/beta-catenin-like repeats 5321 Cytoplasmic phospholipase A2, catalytic subunit 5327 Fibronectin type 1 domain 5327 Trypsin-like serine protease 5327 Fibronectin type 1 domain 5327 Trypsin-like serine protease 5328 Trypsin-like serine protease 5329 Ly-6 antigen / uPA receptor -like domain 5330 Protein kinase C conserved region 2 (CalB) 5331 Protein kinase C conserved region 2 (CalB) 5332 Phospholipase C, catalytic domain (part) 5332 Protein kinase C conserved region 2 (CalB) 5332 Phospholipase C, catalytic domain (part) 5332 Protein kinase C conserved region 2 (CalB) 5333 Phospholipase C, catalytic domain (part) 5333 Protein kinase C conserved region 2 (CalB) 5333 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5334 Phospholipase C, catalytic domain (part) 5334 Phospholipase C, catalytic domain (part) 5334 Protein kinase C conserved region 2 (CalB) 5335 Src homology 2 domains 5335 Phospholipase C, catalytic domain (part) 5335 Protein kinase C conserved region 2 (CalB) 5335 Src homology 2 domains 5335 Phospholipase C, catalytic domain (part) 5335 Protein kinase C conserved region 2 (CalB) 5336 Src homology 2 domains 5336 Phospholipase C, catalytic domain (part) 5336 Phospholipase C, catalytic domain (part) 5336 Protein kinase C conserved region 2 (CalB) 5337 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5339 Plectin repeat 5340 Kringle domain 5340 Trypsin-like serine protease 5340 divergent subfamily of APPLE domains 5341 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5347 Serine/Threonine protein kinases, catalytic domain 5351 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 5352 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 5352 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 5361 semaphorin domain 5361 ig-like, plexins, transcription factors 5361 domain found in Plexins, Semaphorins and Integrins 5364 semaphorin domain 5364 ig-like, plexins, transcription factors 5364 GTPase-activator protein for Ras-like GTPases 5364 domain found in Plexins, Semaphorins and Integrins 5365 semaphorin domain 5365 GTPase-activator protein for Ras-like GTPases 5365 domain found in Plexins, Semaphorins and Integrins 5371 Ring finger 5371 B-Box-type zinc finger 5371 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 5371 Ring finger 5371 B-Box-type zinc finger 5371 Ring finger 5371 B-Box-type zinc finger 5371 Ring finger 5371 B-Box-type zinc finger 5371 Ring finger 5371 B-Box-type zinc finger 5371 Ring finger 5378 high mobility group 5387 krueppel associated box 5423 DNA polymerase X family 5432 RNA polymerases D 5432 RNA polymerases D 5438 C2C2 Zinc finger 5440 RNA polymerase subunit CX 5449 Found in Pit-Oct-Unc transcription factors 5451 Found in Pit-Oct-Unc transcription factors 5452 Found in Pit-Oct-Unc transcription factors 5453 Found in Pit-Oct-Unc transcription factors 5454 Found in Pit-Oct-Unc transcription factors 5455 Found in Pit-Oct-Unc transcription factors 5456 Found in Pit-Oct-Unc transcription factors 5460 Found in Pit-Oct-Unc transcription factors 5470 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5470 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5475 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5475 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5475 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5475 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 5475 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5475 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5494 Serine/threonine phosphatases, family 2C, catalytic domain 5494 Serine/threonine phosphatases, family 2C, catalytic domain 5494 Serine/threonine phosphatases, family 2C, catalytic domain 5495 Serine/threonine phosphatases, family 2C, catalytic domain 5495 Serine/threonine phosphatases, family 2C, catalytic domain 5496 Serine/threonine phosphatases, family 2C, catalytic domain 5496 Serine/threonine phosphatases, family 2C, catalytic domain 5499 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5500 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5501 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5514 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 5515 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5516 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5530 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5531 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5532 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5533 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5536 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5537 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 5553 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 5562 Serine/Threonine protein kinases, catalytic domain 5563 Serine/Threonine protein kinases, catalytic domain 5566 Serine/Threonine protein kinases, catalytic domain 5567 Serine/Threonine protein kinases, catalytic domain 5567 Serine/Threonine protein kinases, catalytic domain 5568 Serine/Threonine protein kinases, catalytic domain 5571 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 5573 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 5576 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 5577 Cyclic nucleotide-monophosphate binding domain 5577 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 5578 Serine/Threonine protein kinases, catalytic domain 5579 Serine/Threonine protein kinases, catalytic domain 5580 Serine/Threonine protein kinases, catalytic domain 5581 Protein kinase C conserved region 2 (CalB) 5581 Serine/Threonine protein kinases, catalytic domain 5582 Protein kinase C conserved region 2 (CalB) 5582 Serine/Threonine protein kinases, catalytic domain 5583 Protein kinase C conserved region 2 (CalB) 5583 Serine/Threonine protein kinases, catalytic domain 5584 PB1 domain 5584 Serine/Threonine protein kinases, catalytic domain 5585 Extension to Ser/Thr-type protein kinases 5585 Serine/Threonine protein kinases, catalytic domain 5586 Serine/Threonine protein kinases, catalytic domain 5587 Serine/Threonine protein kinases, catalytic domain 5587 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5588 Serine/Threonine protein kinases, catalytic domain 5590 PB1 domain 5590 Serine/Threonine protein kinases, catalytic domain 5592 Cyclic nucleotide-monophosphate binding domain 5592 Serine/Threonine protein kinases, catalytic domain 5593 Serine/Threonine protein kinases, catalytic domain 5594 Serine/Threonine protein kinases, catalytic domain 5594 Serine/Threonine protein kinases, catalytic domain 5595 Tyrosine kinase, catalytic domain 5595 Serine/Threonine protein kinases, catalytic domain 5596 Serine/Threonine protein kinases, catalytic domain 5597 Serine/Threonine protein kinases, catalytic domain 5598 Serine/Threonine protein kinases, catalytic domain 5598 Serine/Threonine protein kinases, catalytic domain 5598 Serine/Threonine protein kinases, catalytic domain 5598 Serine/Threonine protein kinases, catalytic domain 5599 Serine/Threonine protein kinases, catalytic domain 5599 Serine/Threonine protein kinases, catalytic domain 5599 Serine/Threonine protein kinases, catalytic domain 5599 Serine/Threonine protein kinases, catalytic domain 5600 Serine/Threonine protein kinases, catalytic domain 5600 Serine/Threonine protein kinases, catalytic domain 5601 Serine/Threonine protein kinases, catalytic domain 5601 Serine/Threonine protein kinases, catalytic domain 5601 Serine/Threonine protein kinases, catalytic domain 5601 Serine/Threonine protein kinases, catalytic domain 5602 Serine/Threonine protein kinases, catalytic domain 5602 Serine/Threonine protein kinases, catalytic domain 5602 Serine/Threonine protein kinases, catalytic domain 5602 Serine/Threonine protein kinases, catalytic domain 5603 Serine/Threonine protein kinases, catalytic domain 5604 Serine/Threonine protein kinases, catalytic domain 5605 Serine/Threonine protein kinases, catalytic domain 5606 Serine/Threonine protein kinases, catalytic domain 5606 Serine/Threonine protein kinases, catalytic domain 5606 Serine/Threonine protein kinases, catalytic domain 5607 PB1 domain 5607 Serine/Threonine protein kinases, catalytic domain 5607 PB1 domain 5607 Serine/Threonine protein kinases, catalytic domain 5607 PB1 domain 5607 Serine/Threonine protein kinases, catalytic domain 5607 Serine/Threonine protein kinases, catalytic domain 5608 Serine/Threonine protein kinases, catalytic domain 5608 Serine/Threonine protein kinases, catalytic domain 5609 Serine/Threonine protein kinases, catalytic domain 5609 Serine/Threonine protein kinases, catalytic domain 5610 Double-stranded RNA binding motif 5610 Serine/Threonine protein kinases, catalytic domain 5612 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 5613 Serine/Threonine protein kinases, catalytic domain 5616 Serine/Threonine protein kinases, catalytic domain 5618 Fibronectin type 3 domain 5621 Major prion protein 5624 Trypsin-like serine protease 5624 Epidermal growth factor-like domain 5624 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 5627 Laminin G domain 5627 Calcium-binding EGF-like domain 5627 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 5638 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 5639 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 5644 Trypsin-like serine protease 5645 Trypsin-like serine protease 5646 Trypsin-like serine protease 5648 Trypsin-like serine protease 5648 Domain abundant in complement control proteins 5648 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 5648 Trypsin-like serine protease 5648 Domain abundant in complement control proteins 5648 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 5650 Trypsin-like serine protease 5650 Trypsin-like serine protease 5651 Trypsin-like serine protease 5651 Low-density lipoprotein receptor domain class A 5651 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 5652 Trypsin-like serine protease 5653 Trypsin-like serine protease 5654 Insulin growth factor-binding protein homologues 5655 Trypsin-like serine protease 5655 Trypsin-like serine protease 5657 Trypsin-like serine protease 5662 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5669 Immunoglobulin 5669 Immunoglobulin C-2 Type 5670 Immunoglobulin 5671 Immunoglobulin 5671 Immunoglobulin C-2 Type 5672 Immunoglobulin C-2 Type 5673 Immunoglobulin 5673 Immunoglobulin C-2 Type 5675 Immunoglobulin 5675 Immunoglobulin C-2 Type 5676 Immunoglobulin 5676 Immunoglobulin C-2 Type 5678 Immunoglobulin 5678 Immunoglobulin C-2 Type 5680 Immunoglobulin 5681 Serine/Threonine protein kinases, catalytic domain 5709 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 5719 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 5719 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 5725 RNA recognition motif 5725 RNA recognition motif 5725 RNA recognition motif 5725 RNA recognition motif 5745 Domain present in hormone receptors 5746 Domain present in hormone receptors 5747 Band 4.1 homologues 5747 Tyrosine kinase, catalytic domain 5747 Band 4.1 homologues 5747 Tyrosine kinase, catalytic domain 5753 Src homology 2 domains 5753 Src homology 3 domains 5753 Tyrosine kinase, catalytic domain 5754 Immunoglobulin 5754 Immunoglobulin C-2 Type 5754 Tyrosine kinase, catalytic domain 5754 Immunoglobulin 5754 Immunoglobulin C-2 Type 5754 Tyrosine kinase, catalytic domain 5754 Immunoglobulin 5754 Immunoglobulin C-2 Type 5754 Tyrosine kinase, catalytic domain 5754 Immunoglobulin 5754 Immunoglobulin C-2 Type 5754 Tyrosine kinase, catalytic domain 5754 Immunoglobulin 5754 Immunoglobulin C-2 Type 5756 Actin depolymerisation factor/cofilin -like domains 5764 Pleiotrophin / midkine family 5770 Protein tyrosine phosphatase, catalytic domain 5771 Protein tyrosine phosphatase, catalytic domain 5771 Protein tyrosine phosphatase, catalytic domain 5771 Protein tyrosine phosphatase, catalytic domain 5774 Protein tyrosine phosphatase, catalytic domain 5775 Protein tyrosine phosphatase, catalytic domain 5777 Protein tyrosine phosphatase, catalytic domain 5777 Protein tyrosine phosphatase, catalytic domain 5777 Protein tyrosine phosphatase, catalytic domain 5778 Protein tyrosine phosphatase, catalytic domain 5778 Protein tyrosine phosphatase, catalytic domain 5778 Protein tyrosine phosphatase, catalytic domain 5780 Protein tyrosine phosphatase, catalytic domain 5781 Protein tyrosine phosphatase, catalytic domain 5782 Protein tyrosine phosphatase, catalytic domain 5783 Band 4.1 homologues 5783 Protein tyrosine phosphatase, catalytic domain 5783 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5783 Band 4.1 homologues 5783 Protein tyrosine phosphatase, catalytic domain 5783 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5783 Band 4.1 homologues 5783 Protein tyrosine phosphatase, catalytic domain 5783 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5783 Band 4.1 homologues 5783 Protein tyrosine phosphatase, catalytic domain 5783 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5784 Band 4.1 homologues 5784 Protein tyrosine phosphatase, catalytic domain 5786 Protein tyrosine phosphatase, catalytic domain 5786 Protein tyrosine phosphatase, catalytic domain 5786 Protein tyrosine phosphatase, catalytic domain 5787 Fibronectin type 3 domain 5787 Protein tyrosine phosphatase, catalytic domain 5788 Fibronectin type 3 domain 5788 Protein tyrosine phosphatase, catalytic domain 5788 Fibronectin type 3 domain 5788 Protein tyrosine phosphatase, catalytic domain 5788 Fibronectin type 3 domain 5788 Protein tyrosine phosphatase, catalytic domain 5789 Immunoglobulin 5789 Immunoglobulin C-2 Type 5789 Fibronectin type 3 domain 5789 Protein tyrosine phosphatase, catalytic domain 5789 Immunoglobulin 5789 Immunoglobulin C-2 Type 5789 Fibronectin type 3 domain 5789 Protein tyrosine phosphatase, catalytic domain 5789 Immunoglobulin 5789 Immunoglobulin C-2 Type 5789 Fibronectin type 3 domain 5789 Protein tyrosine phosphatase, catalytic domain 5789 Immunoglobulin 5789 Immunoglobulin C-2 Type 5789 Fibronectin type 3 domain 5789 Protein tyrosine phosphatase, catalytic domain 5791 Protein tyrosine phosphatase, catalytic domain 5791 Protein tyrosine phosphatase, catalytic domain 5792 Immunoglobulin 5792 Immunoglobulin C-2 Type 5792 Fibronectin type 3 domain 5792 Protein tyrosine phosphatase, catalytic domain 5792 Immunoglobulin 5792 Immunoglobulin C-2 Type 5792 Fibronectin type 3 domain 5792 Protein tyrosine phosphatase, catalytic domain 5793 Fibronectin type 3 domain 5793 Protein tyrosine phosphatase, catalytic domain 5794 Fibronectin type 3 domain 5794 Protein tyrosine phosphatase, catalytic domain 5795 Fibronectin type 3 domain 5795 Protein tyrosine phosphatase, catalytic domain 5796 Immunoglobulin 5796 Fibronectin type 3 domain 5796 Protein tyrosine phosphatase, catalytic domain 5796 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 5797 Immunoglobulin 5797 Fibronectin type 3 domain 5797 Protein tyrosine phosphatase, catalytic domain 5797 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 5798 Protein tyrosine phosphatase, catalytic domain 5799 Protein tyrosine phosphatase, catalytic domain 5799 Protein tyrosine phosphatase, catalytic domain 5799 Protein tyrosine phosphatase, catalytic domain 5800 Protein tyrosine phosphatase, catalytic domain 5800 Protein tyrosine phosphatase, catalytic domain 5800 Protein tyrosine phosphatase, catalytic domain 5800 Protein tyrosine phosphatase, catalytic domain 5800 Protein tyrosine phosphatase, catalytic domain 5800 Protein tyrosine phosphatase, catalytic domain 5801 Protein tyrosine phosphatase, catalytic domain 5801 Protein tyrosine phosphatase, catalytic domain 5802 Immunoglobulin 5802 Immunoglobulin C-2 Type 5802 Fibronectin type 3 domain 5802 Protein tyrosine phosphatase, catalytic domain 5802 Immunoglobulin 5802 Immunoglobulin C-2 Type 5802 Fibronectin type 3 domain 5802 Protein tyrosine phosphatase, catalytic domain 5802 Immunoglobulin 5802 Immunoglobulin C-2 Type 5802 Fibronectin type 3 domain 5802 Protein tyrosine phosphatase, catalytic domain 5802 Immunoglobulin 5802 Immunoglobulin C-2 Type 5802 Fibronectin type 3 domain 5802 Protein tyrosine phosphatase, catalytic domain 5803 Protein tyrosine phosphatase, catalytic domain 5806 Pentraxin / C-reactive protein / pentaxin family 5813 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 5814 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 5817 Immunoglobulin V-Type 5818 Immunoglobulin V-Type 5818 Immunoglobulin C-2 Type 5819 Immunoglobulin V-Type 5862 Rab subfamily of small GTPases 5863 Guanine nucleotide exchange factor for Ras-like GTPases 5863 Guanine nucleotide exchange factor for Ras-like small GTPases 5864 Rab subfamily of small GTPases 5865 Rab subfamily of small GTPases 5867 Rab subfamily of small GTPases 5870 Rab subfamily of small GTPases 5871 Serine/Threonine protein kinases, catalytic domain 5871 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 5872 Rab subfamily of small GTPases 5879 Rho (Ras homology) subfamily of Ras-like small GTPases 5879 Rho (Ras homology) subfamily of Ras-like small GTPases 5880 Rho (Ras homology) subfamily of Ras-like small GTPases 5881 Rho (Ras homology) subfamily of Ras-like small GTPases 5886 Ubiquitin homologues 5886 Ubiquitin associated domain 5887 Ubiquitin associated domain 5891 Serine/Threonine protein kinases, catalytic domain 5898 Ras subfamily of RAS small GTPases 5899 Ras subfamily of RAS small GTPases 5900 Guanine nucleotide exchange factor for Ras-like GTPases 5900 Guanine nucleotide exchange factor for Ras-like small GTPases 5901 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 5906 Ras subfamily of RAS small GTPases 5908 Ras subfamily of RAS small GTPases 5909 LGN motif, putative GEFs specific for G-alpha GTPases 5911 Ras subfamily of RAS small GTPases 5912 Ras subfamily of RAS small GTPases 5921 GTPase-activator protein for Ras-like GTPases 5921 GTPase-activator protein for Ras-like GTPases 5922 Protein kinase C conserved region 2 (CalB) 5922 GTPase-activator protein for Ras-like GTPases 5923 Guanine nucleotide exchange factor for Ras-like GTPases 5923 Guanine nucleotide exchange factor for Ras-like small GTPases 5923 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 5923 Guanine nucleotide exchange factor for Ras-like GTPases 5923 Guanine nucleotide exchange factor for Ras-like small GTPases 5924 Guanine nucleotide exchange factor for Ras-like GTPases 5924 Guanine nucleotide exchange factor for Ras-like small GTPases 5924 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 5924 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 5926 Tudor domain 5926 Chromatin organization modifier domain 5926 Tudor domain 5926 Chromatin organization modifier domain 5926 Tudor domain 5926 Chromatin organization modifier domain 5935 RNA recognition motif 5936 RNA recognition motif 5937 RNA recognition motif 5937 RNA recognition motif 5937 RNA recognition motif 5937 RNA recognition motif 5937 RNA recognition motif 5939 RNA recognition motif 5940 RNA recognition motif 5966 ig-like, plexins, transcription factors 5967 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 5968 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 5970 ig-like, plexins, transcription factors 5971 ig-like, plexins, transcription factors 5979 Tyrosine kinase, catalytic domain 5979 Tyrosine kinase, catalytic domain 5979 Tyrosine kinase, catalytic domain 5979 Tyrosine kinase, catalytic domain 5987 Ring finger 5987 associated with SPRY domains 5987 Domain in SPla and the RYanodine Receptor. 5987 Ring finger 5987 associated with SPRY domains 5988 associated with SPRY domains 5988 Domain in SPla and the RYanodine Receptor. 5998 Regulator of G protein signalling domain 5998 Regulator of G protein signalling domain 5998 Regulator of G protein signalling domain 5998 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5998 Regulator of G protein signalling domain 5998 Regulator of G protein signalling domain 5998 Protein kinase C conserved region 2 (CalB) 5998 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 5998 Regulator of G protein signalling domain 6000 G protein gamma subunit-like motifs 6001 Regulator of G protein signalling domain 6002 Regulator of G protein signalling domain 6002 LGN motif, putative GEFs specific for G-alpha GTPases 6002 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 6003 Regulator of G protein signalling domain 6003 Regulator of G protein signalling domain 6004 Regulator of G protein signalling domain 6009 Ras subfamily of RAS small GTPases 6011 Serine/Threonine protein kinases, catalytic domain 6014 Ras subfamily of RAS small GTPases 6016 Ras subfamily of RAS small GTPases 6035 Pancreatic ribonuclease 6036 Pancreatic ribonuclease 6037 Pancreatic ribonuclease 6038 Pancreatic ribonuclease 6039 Pancreatic ribonuclease 6041 domain in protein kinases, N-glycanases and other nuclear proteins 6046 bromo domain 6049 Ring finger 6091 Immunoglobulin 6091 Fibronectin type 3 domain 6091 Immunoglobulin 6091 Fibronectin type 3 domain 6092 Immunoglobulin 6092 Immunoglobulin C-2 Type 6092 Fibronectin type 3 domain 6093 Serine/Threonine protein kinases, catalytic domain 6093 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 6098 Fibronectin type 3 domain 6098 Tyrosine kinase, catalytic domain 6101 Domain in the Doublecortin (DCX) gene product 6102 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 6102 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 6136 Ribosomal protein L11/L12 6195 Serine/Threonine protein kinases, catalytic domain 6196 Serine/Threonine protein kinases, catalytic domain 6197 Serine/Threonine protein kinases, catalytic domain 6198 Serine/Threonine protein kinases, catalytic domain 6199 Serine/Threonine protein kinases, catalytic domain 6236 Ras subfamily of RAS small GTPases 6237 Ras subfamily of RAS small GTPases 6242 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6248 Ubiquitin associated domain 6259 Tyrosine kinase, catalytic domain 6259 Wnt-inhibitory factor-1 like domain 6261 Domain in SPla and the RYanodine Receptor. 6261 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 6262 Domain in SPla and the RYanodine Receptor. 6262 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 6263 Domain in SPla and the RYanodine Receptor. 6263 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 6272 VPS10 domain 6282 EF-hand, calcium binding motif 6294 RNA recognition motif 6300 Serine/Threonine protein kinases, catalytic domain 6304 Homeodomain 6310 domain in Ataxins and HMG containing proteins 6317 SERine Proteinase INhibitors 6318 SERine Proteinase INhibitors 6327 Immunoglobulin V-Type 6330 Immunoglobulin V-Type 6346 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6348 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6352 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6356 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6357 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6358 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6358 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6358 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6359 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6359 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6359 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6360 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6361 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6362 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6363 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6364 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6366 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6367 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6368 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6368 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6369 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6370 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6375 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6376 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6386 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 6388 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 6401 Domain abundant in complement control proteins 6401 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 6402 Domain abundant in complement control proteins 6403 Domain abundant in complement control proteins 6405 Immunoglobulin 6405 domain found in Plexins, Semaphorins and Integrins 6416 Serine/Threonine protein kinases, catalytic domain 6421 RNA recognition motif 6422 Frizzled 6422 Netrin C-terminal Domain 6423 Frizzled 6423 Netrin C-terminal Domain 6424 Frizzled 6425 Frizzled 6425 Netrin C-terminal Domain 6426 RNA recognition motif 6427 RNA recognition motif 6428 RNA recognition motif 6429 RNA recognition motif 6430 RNA recognition motif 6431 RNA recognition motif 6432 RNA recognition motif 6433 Suppressor-of-White-APricot splicing regulator 6434 RNA recognition motif 6440 Pulmonary surfactant proteins 6446 Serine/Threonine protein kinases, catalytic domain 6452 Src homology 2 domains 6452 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6453 Eps15 homology domain 6453 Src homology 3 domains 6453 Protein kinase C conserved region 2 (CalB) 6453 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 6455 BAR domain 6455 Src homology 3 domains 6456 BAR domain 6456 Src homology 3 domains 6457 BAR domain 6457 Src homology 3 domains 6461 Src homology 2 domains 6469 Hint (Hedgehog/Intein) domain N-terminal region 6476 P or trefoil or TFF domain 6490 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 6492 PAS domain 6492 helix loop helix domain 6492 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 6493 PAS domain 6493 helix loop helix domain 6493 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 6493 PAS domain 6493 helix loop helix domain 6493 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 6495 Homeodomain 6496 Homeodomain 6502 A Receptor for Ubiquitination Targets 6502 A Receptor for Ubiquitination Targets 6503 Src homology 2 domains 6503 Src homology 3 domains 6519 Alpha-amylase domain 6543 Domains in Na-Ca exchangers and integrin-beta4 6546 Domains in Na-Ca exchangers and integrin-beta4 6585 Laminin G domain 6586 Laminin G domain 6586 Calcium-binding EGF-like domain 6590 Four-disulfide core domains 6594 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 6594 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 6595 bromo domain 6595 domain in transcription and CHROMO domain helicases 6595 domain in helicases and associated with SANT domains 6595 bromo domain 6595 domain in transcription and CHROMO domain helicases 6595 domain in helicases and associated with SANT domains 6597 bromo domain 6597 domain in transcription and CHROMO domain helicases 6597 domain in helicases and associated with SANT domains 6601 Chromatin organization modifier domain 6601 Chromatin organization modifier domain 6606 Tudor domain 6606 Tudor domain 6607 Tudor domain 6607 Tudor domain 6607 Tudor domain 6607 Tudor domain 6608 Frizzled 6614 Immunoglobulin 6614 Immunoglobulin 6614 Immunoglobulin C-2 Type 6616 Helical region found in SNAREs 6616 Helical region found in SNAREs 6621 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 6625 RNA recognition motif 6626 RNA recognition motif 6628 snRNP Sm proteins 6629 RNA recognition motif 6635 snRNP Sm proteins 6636 snRNP Sm proteins 6638 snRNP Sm proteins 6638 snRNP Sm proteins 6638 snRNP Sm proteins 6638 snRNP Sm proteins 6638 snRNP Sm proteins 6640 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 6641 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6645 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 6645 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6645 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 6650 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 6651 glycine rich nucleic binding domain 6651 glycine rich nucleic binding domain 6651 glycine rich nucleic binding domain 6653 VPS10 domain 6653 Low-density lipoprotein-receptor YWTD domain 6653 Low-density lipoprotein receptor domain class A 6653 Low-density lipoprotein receptor domain class A 6654 Histone 2A 6654 Guanine nucleotide exchange factor for Ras-like GTPases 6654 Guanine nucleotide exchange factor for Ras-like small GTPases 6654 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 6654 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6655 Guanine nucleotide exchange factor for Ras-like small GTPases 6657 high mobility group 6667 zinc finger 6670 zinc finger 6674 Tetratricopeptide repeats 6674 Tetratricopeptide repeats 6678 Follistatin-N-terminal domain-like 6692 Low-density lipoprotein receptor domain class A 6692 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 6692 Low-density lipoprotein receptor domain class A 6692 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 6695 Kazal type serine protease inhibitors 6709 Spectrin repeats 6710 Spectrin repeats 6711 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6711 Spectrin repeats 6712 Spectrin repeats 6712 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 6714 Tyrosine kinase, catalytic domain 6725 Src homology 2 domains 6725 Src homology 3 domains 6725 Tyrosine kinase, catalytic domain 6732 Serine/Threonine protein kinases, catalytic domain 6733 Serine/Threonine protein kinases, catalytic domain 6733 Serine/Threonine protein kinases, catalytic domain 6737 associated with SPRY domains 6737 Domain in SPla and the RYanodine Receptor. 6741 Domain in the RNA-binding Lupus La protein 6756 krueppel associated box 6757 krueppel associated box 6757 krueppel associated box 6758 krueppel associated box 6758 krueppel associated box 6759 krueppel associated box 6759 krueppel associated box 6768 Trypsin-like serine protease 6768 Low-density lipoprotein receptor domain class A 6769 Src homology 3 domains 6780 Double-stranded RNA binding motif 6780 Double-stranded RNA binding motif 6780 Double-stranded RNA binding motif 6780 Double-stranded RNA binding motif 6786 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 6787 Serine/Threonine protein kinases, catalytic domain 6788 Serine/Threonine protein kinases, catalytic domain 6789 Serine/Threonine protein kinases, catalytic domain 6790 Serine/Threonine protein kinases, catalytic domain 6792 Serine/Threonine protein kinases, catalytic domain 6793 Serine/Threonine protein kinases, catalytic domain 6794 Serine/Threonine protein kinases, catalytic domain 6795 Serine/Threonine protein kinases, catalytic domain 6811 Helical region found in SNAREs 6815 Dual specificity phosphatase, catalytic domain 6830 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 6832 helicase superfamily c-terminal domain 6839 Chromatin organization modifier domain 6840 Gelsolin homology domain 6840 Gelsolin homology domain 6846 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 6850 Tyrosine kinase, catalytic domain 6860 Protein kinase C conserved region 2 (CalB) 6861 Protein kinase C conserved region 2 (CalB) 6868 Homologues of snake disintegrins 6868 Homologues of snake disintegrins 6872 bromo domain 6872 bromo domain 6874 TAF homology 6875 TAF homology 6887 helix loop helix domain 6892 Immunoglobulin C-Type 6892 Immunoglobulin C-Type 6895 Double-stranded RNA binding motif 6895 Double-stranded RNA binding motif 6895 Double-stranded RNA binding motif 6899 Domain first found in the mice T locus (Brachyury) protein 6899 Domain first found in the mice T locus (Brachyury) protein 6899 Domain first found in the mice T locus (Brachyury) protein 6900 Immunoglobulin 6900 Immunoglobulin C-2 Type 6900 Fibronectin type 3 domain 6901 Phosphate acyltransferases 6901 Phosphate acyltransferases 6903 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 6907 Lissencephaly type-1-like homology motif 6909 Domain first found in the mice T locus (Brachyury) protein 6910 Domain first found in the mice T locus (Brachyury) protein 6910 Domain first found in the mice T locus (Brachyury) protein 6910 Domain first found in the mice T locus (Brachyury) protein 6910 Domain first found in the mice T locus (Brachyury) protein 6911 Domain first found in the mice T locus (Brachyury) protein 6911 Domain first found in the mice T locus (Brachyury) protein 6917 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 6917 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 6919 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 6919 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 6920 C2C2 Zinc finger 6920 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 6920 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 6921 Found in Skp1 protein family 6923 Ubiquitin homologues 6924 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 6925 helix loop helix domain 6926 Domain first found in the mice T locus (Brachyury) protein 6926 Domain first found in the mice T locus (Brachyury) protein 6927 Homeodomain 6928 Homeodomain 6928 Homeodomain 6935 Homeodomain 6939 helix loop helix domain 6940 krueppel associated box 6949 Lissencephaly type-1-like homology motif 6955 Immunoglobulin 6955 Immunoglobulin V-Type 6975 Zona pellucida (ZP) domain 7006 Src homology 2 domains 7006 Tyrosine kinase, catalytic domain 7006 Bruton's tyrosine kinase Cys-rich motif 7006 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 7007 von Willebrand factor (vWF) type D domain 7007 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 7008 basic region leucin zipper 7010 Immunoglobulin 7010 Fibronectin type 3 domain 7010 Tyrosine kinase, catalytic domain 7013 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 7013 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 7014 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 7018 Transferrin 7035 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 7038 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 7044 Transforming growth factor-beta (TGF-beta) family 7045 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 7046 GS motif 7050 Homeodomain 7050 Homeodomain 7050 Homeodomain 7050 Homeodomain 7050 Homeodomain 7050 Homeodomain 7050 Homeodomain 7050 Homeodomain 7056 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 7057 Laminin G domain 7057 Thrombospondin type 1 repeats 7058 Thrombospondin type 1 repeats 7058 Calcium-binding EGF-like domain 7058 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 7059 Calcium-binding EGF-like domain 7059 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 7060 Calcium-binding EGF-like domain 7067 Ligand binding domain of hormone receptors 7070 Immunoglobulin V-Type 7074 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 7074 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 7074 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 7075 Tyrosine kinase, catalytic domain 7075 Laminin-type epidermal growth factor-like domai 7078 Tissue inhibitor of metalloproteinase family. Form complexes with metalloproteinases, such as collagenases, and irreversibly inactivate them 7082 Domain present in ZO-1 and Unc5-like netrin receptors 7082 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 7082 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 7082 Domain present in ZO-1 and Unc5-like netrin receptors 7082 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 7082 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 7092 Calcium-binding EGF-like domain 7093 Calcium-binding EGF-like domain 7094 I/LWEQ domain 7096 Leucine rich repeat C-terminal domain 7097 Leucine rich repeat C-terminal domain 7098 Leucine rich repeat C-terminal domain 7113 Scavenger receptor Cys-rich 7113 Trypsin-like serine protease 7113 Low-density lipoprotein receptor domain class A 7123 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 7128 A20-like zinc fingers 7132 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 7133 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 7143 Fibronectin type 3 domain 7143 Fibrinogen-related domains (FReDs) 7145 Src homology 2 domains 7145 Protein tyrosine phosphatase, catalytic domain motif 7145 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 7150 DNA Topoisomerase I (eukaryota) 7153 TopoisomeraseII 7153 DNA Topoisomerase IV 7155 TopoisomeraseII 7155 DNA Topoisomerase IV 7158 Tudor domain 7158 breast cancer carboxy-terminal domain 7159 Src homology 3 domains 7161 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 7162 Leucine rich repeat C-terminal domain 7162 Leucine rich repeat N-terminal domain 7173 Calcium-binding EGF-like domain 7173 Domain abundant in complement control proteins 7173 Calcium-binding EGF-like domain 7173 Domain abundant in complement control proteins 7173 Calcium-binding EGF-like domain 7173 Domain abundant in complement control proteins 7173 Domain abundant in complement control proteins 7173 Calcium-binding EGF-like domain 7173 Domain abundant in complement control proteins 7176 Trypsin-like serine protease 7176 Trypsin-like serine protease 7177 Trypsin-like serine protease 7180 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 7204 Immunoglobulin 7204 Spectrin repeats 7204 Src homology 3 domains 7204 Serine/Threonine protein kinases, catalytic domain 7204 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 7204 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 7204 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 7205 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 7251 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 7252 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 7262 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 7266 Tetratricopeptide repeats 7272 Serine/Threonine protein kinases, catalytic domain 7273 Immunoglobulin 7276 Transthyretin 7292 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 7294 Src homology 2 domains 7294 Tyrosine kinase, catalytic domain 7297 Band 4.1 homologues 7297 Src homology 2 domains 7297 Tyrosine kinase, catalytic domain 7301 Immunoglobulin 7301 Tyrosine kinase, catalytic domain 7307 RRM_1 domain 7316 Ubiquitin homologues 7328 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 7332 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 7335 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 7337 Domain Homologous to E6-AP Carboxyl Terminus with 7337 Domain Homologous to E6-AP Carboxyl Terminus with 7337 Domain Homologous to E6-AP Carboxyl Terminus with 7343 high mobility group 7369 Calcium-binding EGF-like domain 7373 Fibronectin type 3 domain 7373 von Willebrand factor (vWF) type A domain 7375 Domain in ubiquitin-specific proteases 7399 Fibronectin type 3 domain 7399 LamG-like jellyroll fold domain 7399 Laminin N-terminal domain (domain VI) 7399 Laminin-type epidermal growth factor-like domai 7402 Spectrin repeats 7402 Domain with 2 conserved Trp (W) residues 7409 Src homology 2 domains 7409 Src homology 3 domains 7410 Src homology 2 domains 7410 Src homology 3 domains 7410 Calponin homology domain 7412 Immunoglobulin 7412 Immunoglobulin 7422 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 7423 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 7424 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 7429 Villin headpiece domain 7429 Gelsolin homology domain 7432 Glucagon like hormones 7433 Domain present in hormone receptors 7434 Domain present in hormone receptors 7436 Calcium-binding EGF-like domain 7436 Low-density lipoprotein receptor domain class A 7441 Immunoglobulin V-Type 7448 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 7450 von Willebrand factor (vWF) type C domain 7450 von Willebrand factor (vWF) type D domain 7450 C-terminal cystine knot-like domain (CTCK) 7455 von Willebrand factor (vWF) type C domain 7455 von Willebrand factor (vWF) type D domain 7455 von Willebrand factor (vWF) type D domain 7455 von Willebrand factor (vWF) type D domain 7455 von Willebrand factor (vWF) type D domain 7455 von Willebrand factor (vWF) type D domain 7455 von Willebrand factor (vWF) type D domain 7458 RNA recognition motif 7458 RNA recognition motif 7464 WD40 repeats 7464 WD40 repeats 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 high mobility group 7468 domain with conserved PWWP motif 7468 domain with conserved PWWP motif 7476 found in Wnt-1 7478 found in Wnt-1 7478 found in Wnt-1 7479 found in Wnt-1 7481 found in Wnt-1 7494 basic region leucin zipper 7525 Tyrosine kinase, catalytic domain 7535 Tyrosine kinase, catalytic domain 7535 Src homology 2 domains 7535 Tyrosine kinase, catalytic domain 7535 Serine/Threonine protein kinases, catalytic domain 7539 krueppel associated box 7553 krueppel associated box 7554 krueppel associated box 7554 krueppel associated box 7556 krueppel associated box 7558 krueppel associated box 7565 krueppel associated box 7566 zinc finger 7566 leucine rich region 7566 krueppel associated box 7567 krueppel associated box 7567 krueppel associated box 7571 krueppel associated box 7572 leucine rich region 7579 leucine rich region 7579 krueppel associated box 7581 krueppel associated box 7586 leucine rich region 7586 krueppel associated box 7587 krueppel associated box 7589 leucine rich region 7592 krueppel associated box 7592 krueppel associated box 7594 krueppel associated box 7596 krueppel associated box 7625 krueppel associated box 7627 krueppel associated box 7633 krueppel associated box 7637 krueppel associated box 7639 krueppel associated box 7644 krueppel associated box 7681 Ring finger 7681 zinc finger 7682 zinc finger 7692 krueppel associated box 7694 krueppel associated box 7699 krueppel associated box 7700 krueppel associated box 7706 associated with SPRY domains 7706 Domain in SPla and the RYanodine Receptor. 7711 krueppel associated box 7712 krueppel associated box 7718 leucine rich region 7726 associated with SPRY domains 7726 Domain in SPla and the RYanodine Receptor. 7727 leucine rich region 7728 krueppel associated box 7730 krueppel associated box 7732 Ring finger 7738 krueppel associated box 7739 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 7745 leucine rich region 7746 leucine rich region 7748 krueppel associated box 7753 leucine rich region 7753 krueppel associated box 7755 krueppel associated box 7757 krueppel associated box 7760 leucine rich region 7760 krueppel associated box 7760 leucine rich region 7760 krueppel associated box 7762 leucine rich region 7762 krueppel associated box 7763 A20-like zinc fingers 7766 krueppel associated box 7767 krueppel associated box 7768 krueppel associated box 7769 krueppel associated box 7769 krueppel associated box 7770 krueppel associated box 7771 krueppel associated box 7773 krueppel associated box 7775 leucine rich region 7791 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 7804 Low-density lipoprotein receptor domain class A 7804 Low-density lipoprotein receptor domain class A 7804 Calcium-binding EGF-like domain 7804 Low-density lipoprotein receptor domain class A 7812 Cold shock protein domain 7813 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 7837 Immunoglobulin 7837 Immunoglobulin C-2 Type 7837 von Willebrand factor (vWF) type C domain 7837 Leucine-rich repeats, typical (most populated) subfamily 7850 Immunoglobulin 7850 Immunoglobulin 7855 Frizzled 7867 Serine/Threonine protein kinases, catalytic domain 7869 domain found in Plexins, Semaphorins and Integrins 7879 ARF-like small GTPases 7879 Rab subfamily of small GTPases 7879 Ras subfamily of RAS small GTPases 7879 Rho (Ras homology) subfamily of Ras-like small GTPases 7879 Sar1p-like members of the Ras-family of small GTPases 7879 ATPases associated with a variety of cellular activities 7879 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 7904 RRM_1 domain 7913 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 7918 glycine rich nucleic binding domain 7936 RNA recognition motif 7957 Dual specificity phosphatase, catalytic domain 7976 Frizzled 7980 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 7984 Src homology 3 domains 7984 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 7994 Domain in histone families 1 and 5 8019 bromo domain 8027 Src homology 3 domains 8029 Calcium-binding EGF-like domain 8029 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 8038 ADAM Cysteine-Rich Domain 8038 Homologues of snake disintegrins 8038 ADAM Cysteine-Rich Domain 8038 Homologues of snake disintegrins 8045 Ras association (RalGDS/AF-6) domain 8061 basic region leucin zipper 8074 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 8085 PHD zinc finger 8085 high mobility group 8085 "FY-rich" domain, C-terminal region 8085 "FY-rich" domain, N-terminal region 8092 Homeodomain 8100 Tetratricopeptide repeats 8100 Tetratricopeptide repeats 8106 RNA recognition motif 8125 occurring C-terminal to leucine-rich repeats 8139 Kelch domain 8148 RNA recognition motif 8148 RNA recognition motif 8153 Rho (Ras homology) subfamily of Ras-like small GTPases 8165 K homology RNA-binding domain 8190 Src homology 3 domains 8200 Transforming growth factor-beta (TGF-beta) family 8202 PAS domain 8202 helix loop helix domain 8202 PAS domain 8202 helix loop helix domain 8218 Clathrin heavy chain repeat homology 8218 Clathrin heavy chain repeat homology 8233 RRM_1 domain 8241 glycine rich nucleic binding domain 8241 RNA recognition motif 8241 glycine rich nucleic binding domain 8290 Histone H3 8291 Protein kinase C conserved region 2 (CalB) 8291 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th 8294 Histone H4 8312 Regulator of G protein signalling domain 8312 Regulator of G protein signalling domain 8313 Domain present in Dishevelled and axin 8313 Regulator of G protein signalling domain 8317 Serine/Threonine protein kinases, catalytic domain 8320 Domain first found in the mice T locus (Brachyury) protein 8321 Frizzled 8322 Frizzled 8323 Frizzled 8324 Frizzled 8325 Frizzled 8326 Frizzled 8327 SAM / Pointed domain 8329 Histone 2A 8330 Histone 2A 8331 Histone 2A 8332 Histone 2A 8334 Histone 2A 8335 Histone 2A 8336 Histone 2A 8337 Histone 2A 8337 Histone 2A 8338 Histone 2A 8339 Histone H2B 8340 Histone H2B 8341 Histone H2B 8342 Histone H2B 8343 Histone H2B 8344 Histone H2B 8345 Histone H2B 8346 Histone H2B 8347 Histone H2B 8348 Histone H2B 8349 Histone H2B 8350 Histone H3 8351 Histone H3 8352 Histone H3 8353 Histone H3 8354 Histone H3 8355 Histone H3 8356 Histone H3 8357 Histone H3 8358 Histone H3 8359 Histone H4 8360 Histone H4 8361 Histone H4 8362 Histone H4 8363 Histone H4 8364 Histone H4 8365 Histone H4 8366 Histone H4 8367 Histone H4 8368 Histone H4 8369 Histone H4 8370 Histone H4 8382 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 8394 Phosphatidylinositol phosphate kinases 8396 Phosphatidylinositol phosphate kinases 8396 Phosphatidylinositol phosphate kinases 8404 Follistatin-N-terminal domain-like 8406 Domain abundant in complement control proteins 8408 Serine/Threonine protein kinases, catalytic domain 8412 Src homology 2 domains 8412 Guanine nucleotide exchange factor for Ras-like small GTPases 8425 Calcium-binding EGF-like domain 8427 krueppel associated box 8427 krueppel associated box 8428 Serine/Threonine protein kinases, catalytic domain 8437 Bruton's tyrosine kinase Cys-rich motif 8437 GTPase-activator protein for Ras-like GTPases 8439 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 8440 Src homology 2 domains 8440 Src homology 3 domains 8440 Src homology 3 domains 8444 Serine/Threonine protein kinases, catalytic domain 8445 Serine/Threonine protein kinases, catalytic domain 8445 Serine/Threonine protein kinases, catalytic domain 8455 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 8455 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 8455 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 8455 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 8455 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 8455 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 8456 FORKHEAD 8467 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 8470 Src homology 3 domains 8470 Src homology 3 domains 8471 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8476 P21-Rho-binding domain 8476 Serine/Threonine protein kinases, catalytic domain 8476 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8476 P21-Rho-binding domain 8476 Serine/Threonine protein kinases, catalytic domain 8476 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8482 semaphorin domain 8483 Immunoglobulin C-2 Type 8483 Thrombospondin type 1 repeats 8490 Regulator of G protein signalling domain 8491 Serine/Threonine protein kinases, catalytic domain 8492 Kringle domain 8492 Scavenger receptor Cys-rich 8492 Trypsin-like serine protease 8493 Serine/threonine phosphatases, family 2C, catalytic domain 8495 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 8496 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8497 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 8498 Ran-binding domain 8498 Ran-binding domain 8498 Ran-binding domain 8499 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8500 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8500 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8502 Armadillo/beta-catenin-like repeats 8503 Src homology 2 domains 8506 Laminin G domain 8507 Kelch domain 8510 ShK toxin domain 8510 Immunoglobulin C-2 Type 8511 ShK toxin domain 8511 Immunoglobulin C-2 Type 8515 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 8516 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 8522 Fes/CIP4 homology domain 8522 Fes/CIP4 homology domain 8522 Domain with 2 conserved Trp (W) residues 8525 Diacylglycerol kinase accessory domain (presumed) 8525 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 8527 Diacylglycerol kinase accessory domain (presumed) 8527 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 8527 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8527 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8527 Diacylglycerol kinase accessory domain (presumed) 8527 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 8527 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8527 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8530 Cystatin-like domain 8532 Frizzled 8532 Zn_pept domain 8533 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 8536 Serine/Threonine protein kinases, catalytic domain 8541 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8541 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 8547 Fibrinogen-related domains (FReDs) 8547 Fibrinogen-related domains (FReDs) 8550 Serine/Threonine protein kinases, catalytic domain 8550 Serine/Threonine protein kinases, catalytic domain 8553 Orange domain 8558 Serine/Threonine protein kinases, catalytic domain 8558 Serine/Threonine protein kinases, catalytic domain 8558 Serine/Threonine protein kinases, catalytic domain 8559 Splicing Factor Motif, present in Prp18 and Pr04 8569 Serine/Threonine protein kinases, catalytic domain 8570 K homology RNA-binding domain 8572 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 8573 Src homology 3 domains 8573 Serine/Threonine protein kinases, catalytic domain 8573 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 8575 Double-stranded RNA binding motif 8577 Kazal type serine protease inhibitors 8600 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8600 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8621 Serine/Threonine protein kinases, catalytic domain 8621 Serine/Threonine protein kinases, catalytic domain 8626 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8629 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 8631 Src homology 3 domains 8631 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8633 Immunoglobulin 8633 Thrombospondin type 1 repeats 8633 Domain present in ZO-1 and Unc5-like netrin receptors 8633 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8641 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 8641 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 8642 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 8646 Domain in SOG (short gastrulation protein) and chordin 8646 Domain in SOG (short gastrulation protein) and chordin 8648 PAS domain 8648 helix loop helix domain 8648 PAS domain 8648 helix loop helix domain 8648 PAS domain 8648 helix loop helix domain 8651 Src homology 2 domains 8651 suppressors of cytokine signalling 8654 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 8654 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 8654 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 8654 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 8658 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 8660 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8660 Phosphotyrosine-binding domain (IRS1-like) 8660 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 8661 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 8663 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 8666 RNA recognition motif 8667 JAB/MPN domain 8676 Syntaxin N-terminal domain 8677 Helical region found in SNAREs 8681 Protein kinase C conserved region 2 (CalB) 8683 RNA recognition motif 8685 Scavenger receptor Cys-rich 8690 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 8693 Ricin-type beta-trefoil 8711 Tyrosine kinase, catalytic domain 8717 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8717 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8728 ADAM Cysteine-Rich Domain 8728 Homologues of snake disintegrins 8728 ADAM Cysteine-Rich Domain 8728 Homologues of snake disintegrins 8736 Immunoglobulin 8736 Fibronectin type 3 domain 8737 Tyrosine kinase, catalytic domain 8738 Caspase recruitment domain 8738 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8740 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8740 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8741 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8741 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8742 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8743 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 8745 ADAM Cysteine-Rich Domain 8745 Homologues of snake disintegrins 8747 ADAM Cysteine-Rich Domain 8747 Homologues of snake disintegrins 8748 ADAM Cysteine-Rich Domain 8748 Homologues of snake disintegrins 8749 ADAM Cysteine-Rich Domain 8749 Homologues of snake disintegrins 8751 ADAM Cysteine-Rich Domain 8751 Homologues of snake disintegrins 8754 ADAM Cysteine-Rich Domain 8754 Homologues of snake disintegrins 8756 ADAM Cysteine-Rich Domain 8756 Homologues of snake disintegrins 8766 Rab subfamily of small GTPases 8773 Helical region found in SNAREs 8773 Helical region found in SNAREs 8776 Protein tyrosine phosphatase, catalytic domain motif 8776 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 8776 Protein tyrosine phosphatase, catalytic domain motif 8776 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 8777 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 8778 Immunoglobulin 8780 RIO-like kinase 8780 RIO-like kinase 8786 G protein gamma subunit-like motifs 8786 Regulator of G protein signalling domain 8787 G protein gamma subunit-like motifs 8787 Regulator of G protein signalling domain 8793 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 8794 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 8795 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 8795 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8795 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 8795 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8796 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 8796 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 8797 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 8797 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 8798 Serine/Threonine protein kinases, catalytic domain 8805 bromo domain 8805 B-Box C-terminal domain 8808 Immunoglobulin 8808 Immunoglobulin C-2 Type 8812 domain present in cyclins, TFIIB and Retinoblastoma 8814 Serine/Threonine protein kinases, catalytic domain 8816 WD40 repeats 8825 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 8826 Domain with 2 conserved Trp (W) residues 8826 GTPase-activator protein for Ras-like GTPases 8828 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 8828 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 8828 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 8828 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 8835 Src homology 2 domains 8835 suppressors of cytokine signalling 8837 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 8838 C-terminal cystine knot-like domain (CTCK) 8838 C-terminal cystine knot-like domain (CTCK) 8840 von Willebrand factor (vWF) type C domain 8840 C-terminal cystine knot-like domain (CTCK) 8844 Tyrosine kinase, catalytic domain 8844 Serine/Threonine protein kinases, catalytic domain 8844 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 8850 bromo domain 8853 Src homology 3 domains 8853 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8857 von Willebrand factor (vWF) type D domain 8858 Trypsin-like serine protease 8858 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 8863 PAS domain 8864 PAS domain 8867 Inositol polyphosphate phosphatase, catalytic domain homologues 8874 Src homology 3 domains 8874 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 8874 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8874 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 8874 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8878 PB1 domain 8878 Ubiquitin associated domain 8878 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 8880 K homology RNA-binding domain 8893 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 8895 von Willebrand factor (vWF) type A domain 8895 Protein kinase C conserved region 2 (CalB) 8897 Protein present in Fab1, YOTB, Vac1, and EEA1 8897 Protein tyrosine phosphatase, catalytic domain motif 8897 Protein present in Fab1, YOTB, Vac1, and EEA1 8897 Protein tyrosine phosphatase, catalytic domain motif 8897 Protein present in Fab1, YOTB, Vac1, and EEA1 8897 Protein tyrosine phosphatase, catalytic domain motif 8898 Protein tyrosine phosphatase, catalytic domain motif 8898 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 8899 Serine/Threonine protein kinases, catalytic domain 8899 Serine/Threonine protein kinases, catalytic domain 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8904 von Willebrand factor (vWF) type A domain 8904 Protein kinase C conserved region 2 (CalB) 8909 Somatomedin B -like domains 8916 Domain Homologous to E6-AP Carboxyl Terminus with 8924 Domain Homologous to E6-AP Carboxyl Terminus with 8925 Domain in SPla and the RYanodine Receptor. 8925 Domain Homologous to E6-AP Carboxyl Terminus with 8928 FORKHEAD 8930 Methyl-CpG binding domain 8934 Rab subfamily of small GTPases 8935 Src homology 3 domains 8935 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 8939 K homology RNA-binding domain 8945 A Receptor for Ubiquitination Targets 8945 A Receptor for Ubiquitination Targets 8968 Histone H3 8969 Histone 2A 8970 Histone H2B 8972 P or trefoil or TFF domain 8974 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 8985 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 8986 Serine/Threonine protein kinases, catalytic domain 8993 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 8994 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 8996 Caspase recruitment domain 8997 Spectrin repeats 8997 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 8997 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 8999 Serine/Threonine protein kinases, catalytic domain 9019 Immunoglobulin V-Type 9020 Serine/Threonine protein kinases, catalytic domain 9021 Src homology 2 domains 9021 suppressors of cytokine signalling 9024 Serine/Threonine protein kinases, catalytic domain 9026 I/LWEQ domain 9026 Epsin N-terminal homology (ENTH) domain 9031 bromo domain 9031 domain in different transcription and chromosome remodeling factors 9031 bromo domain 9031 domain in different transcription and chromosome remodeling factors 9037 Thrombospondin type 1 repeats 9046 Phosphotyrosine-binding domain (IRS1-like) 9046 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9047 Src homology 2 domains 9051 Src homology 3 domains 9051 Fes/CIP4 homology domain 9061 ATPases associated with a variety of cellular activities 9064 Serine/Threonine protein kinases, catalytic domain 9064 Serine/Threonine protein kinases, catalytic domain 9068 Fibrinogen-related domains (FReDs) 9070 Domain in SPla and the RYanodine Receptor. 9077 Ras subfamily of RAS small GTPases 9085 Chromatin organization modifier domain 9085 Chromatin organization modifier domain 9088 Serine/Threonine protein kinases, catalytic domain 9088 Serine/Threonine protein kinases, catalytic domain 9096 Domain first found in the mice T locus (Brachyury) protein 9107 Protein tyrosine phosphatase, catalytic domain motif 9108 Protein tyrosine phosphatase, catalytic domain motif 9110 Protein present in Fab1, YOTB, Vac1, and EEA1 9110 Protein tyrosine phosphatase, catalytic domain motif 9112 Bromo adjacent homology domain 9112 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 9112 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 9113 Serine/Threonine protein kinases, catalytic domain 9128 Splicing Factor Motif, present in Prp18 and Pr04 9138 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9139 TAF homology 9139 TAF homology 9146 Protein present in Fab1, YOTB, Vac1, and EEA1 9148 domain in neuralized proteins 9149 Serine/Threonine protein kinases, catalytic domain 9149 Serine/Threonine protein kinases, catalytic domain 9149 Serine/Threonine protein kinases, catalytic domain 9156 Xeroderma pigmentosum G N-region 9156 Xeroderma pigmentosum G N-region 9156 Xeroderma pigmentosum G N-region 9162 Diacylglycerol kinase accessory domain (presumed) 9172 Immunoglobulin 9172 Fibronectin type 3 domain 9173 Immunoglobulin C-2 Type 9173 Immunoglobulin C-2 Type 9173 Immunoglobulin C-2 Type 9180 Fibronectin type 3 domain 9181 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9181 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 9182 Ras association (RalGDS/AF-6) domain 9185 Eps15 homology domain 9191 Death effector domain 9191 Death effector domain 9201 Domain in the Doublecortin (DCX) gene product 9201 Serine/Threonine protein kinases, catalytic domain 9210 Transforming growth factor-beta (TGF-beta) family 9212 Serine/Threonine protein kinases, catalytic domain 9214 Immunoglobulin V-Type 9219 Bromo adjacent homology domain 9219 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 9219 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 9220 Myosin. Large ATPases. ATPase 9220 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9223 Domain with 2 conserved Trp (W) residues 9223 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9223 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 9230 Rab subfamily of small GTPases 9231 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9231 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 9242 helix loop helix domain 9244 Fibronectin type 3 domain 9252 Serine/Threonine protein kinases, catalytic domain 9252 Serine/Threonine protein kinases, catalytic domain 9254 von Willebrand factor (vWF) type A domain 9256 Src homology 3 domains 9256 Fibronectin type 3 domain 9260 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9260 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 9261 Serine/Threonine protein kinases, catalytic domain 9261 Serine/Threonine protein kinases, catalytic domain 9262 Serine/Threonine protein kinases, catalytic domain 9263 Serine/Threonine protein kinases, catalytic domain 9265 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9266 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9266 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9267 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9267 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9270 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 9270 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 9295 RNA recognition motif 9306 Src homology 2 domains 9306 suppressors of cytokine signalling 9308 Immunoglobulin 9310 krueppel associated box 9313 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 9320 Domain Homologous to E6-AP Carboxyl Terminus with 9322 Src homology 3 domains 9332 Scavenger receptor Cys-rich 9342 Helical region found in SNAREs 9344 Serine/Threonine protein kinases, catalytic domain 9350 C-terminal cystine knot-like domain (CTCK) 9351 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9353 Laminin G domain 9362 von Willebrand factor (vWF) type A domain 9363 Rab subfamily of small GTPases 9364 Rab subfamily of small GTPases 9368 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9369 Laminin G domain 9369 Laminin G domain 9370 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 9378 Laminin G domain 9378 putative band 4.1 homologues' binding motif 9378 Laminin G domain 9378 putative band 4.1 homologues' binding motif 9379 Laminin G domain 9379 Laminin G domain 9379 Laminin G domain 9381 Protein kinase C conserved region 2 (CalB) 9392 Clathrin heavy chain repeat homology 9398 Immunoglobulin V-Type 9402 Src homology 2 domains 9402 Src homology 3 domains 9407 Trypsin-like serine protease 9411 GTPase-activator protein for Rho-like GTPases 9411 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 9414 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9414 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 9421 helix loop helix domain 9422 krueppel associated box 9423 Netrin C-terminal Domain 9423 Laminin N-terminal domain (domain VI) 9425 Chromatin organization modifier domain 9425 Chromatin organization modifier domain 9426 Chromatin organization modifier domain 9436 Immunoglobulin 9441 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 9444 K homology RNA-binding domain 9448 Serine/Threonine protein kinases, catalytic domain 9448 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 9448 Serine/Threonine protein kinases, catalytic domain 9448 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 9448 Serine/Threonine protein kinases, catalytic domain 9448 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 9451 Serine/Threonine protein kinases, catalytic domain 9457 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 9459 Calponin homology domain 9459 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9459 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9462 GTPase-activator protein for Ras-like GTPases 9462 Protein kinase C conserved region 2 (CalB) 9462 GTPase-activator protein for Ras-like GTPases 9463 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9475 Serine/Threonine protein kinases, catalytic domain 9475 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 9479 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 9480 Homeodomain 9482 Helical region found in SNAREs 9496 Domain first found in the mice T locus (Brachyury) protein 9499 Immunoglobulin 9507 ADAM Cysteine-Rich Domain 9507 Thrombospondin type 1 repeats 9508 Thrombospondin type 1 repeats 9509 Thrombospondin type 1 repeats 9510 ADAM Cysteine-Rich Domain 9510 Thrombospondin type 1 repeats 9513 K homology RNA-binding domain 9518 Transforming growth factor-beta (TGF-beta) family 9529 BAG domains, present in regulator of Hsp70 proteins 9531 Domain with 2 conserved Trp (W) residues 9533 RNA polymerases D 9534 krueppel associated box 9542 Immunoglobulin 9542 Immunoglobulin 9542 Immunoglobulin 9542 Immunoglobulin 9542 Immunoglobulin 9542 Immunoglobulin 9543 Immunoglobulin 9543 Immunoglobulin C-2 Type 9543 Immunoglobulin 9543 Immunoglobulin C-2 Type 9543 Fibronectin type 3 domain 9545 Rab subfamily of small GTPases 9552 Putative single-stranded nucleic acids-binding domain 9555 Histone 2A 9555 Histone 2A 9555 Histone 2A 9564 Src homology 3 domains 9573 Transforming growth factor-beta (TGF-beta) family 9575 PAS domain 9575 helix loop helix domain 9575 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 9578 P21-Rho-binding domain 9578 Serine/Threonine protein kinases, catalytic domain 9580 high mobility group 9584 RNA recognition motif 9585 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 9586 basic region leucin zipper 9586 basic region leucin zipper 9595 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9603 basic region leucin zipper 9604 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 9609 Rab subfamily of small GTPases 9610 Src homology 2 domains 9611 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 9620 Laminin G domain 9620 Calcium-binding EGF-like domain 9620 Domain present in hormone receptors 9620 G-protein-coupled receptor proteolytic site domain 9620 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 9622 Trypsin-like serine protease 9625 Tyrosine kinase, catalytic domain 9625 Serine/Threonine protein kinases, catalytic domain 9628 G protein gamma subunit-like motifs 9628 Regulator of G protein signalling domain 9635 von Willebrand factor (vWF) type A domain 9636 Ubiquitin homologues 9639 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9641 Serine/Threonine protein kinases, catalytic domain 9644 Src homology 3 domains 9645 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 9647 Serine/threonine phosphatases, family 2C, catalytic domain 9649 Guanine nucleotide exchange factor for Ras-like small GTPases 9655 Src homology 2 domains 9655 suppressors of cytokine signalling 9655 Src homology 2 domains 9655 suppressors of cytokine signalling 9657 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 9665 RNA recognition motif 9666 Ring finger 9667 RNA recognition motif 9668 krueppel associated box 9671 present in yeast cell wall integrity and stress response component proteins 9682 Tudor domain 9690 Domain Homologous to E6-AP Carboxyl Terminus with 9693 Ras association (RalGDS/AF-6) domain 9693 Cyclic nucleotide-monophosphate binding domain 9693 Guanine nucleotide exchange factor for Ras-like GTPases 9693 Guanine nucleotide exchange factor for Ras-like small GTPases 9693 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9699 Protein kinase C conserved region 2 (CalB) 9699 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9706 Serine/Threonine protein kinases, catalytic domain 9708 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 9708 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 9711 domain involved in Ras-like GTPase signaling 9712 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 9714 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 9716 DEAD-like helicases superfamily 9717 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 9719 Thrombospondin type 1 repeats 9722 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 9723 domain found in Plexins, Semaphorins and Integrins 9732 Src homology 3 domains 9733 RNA recognition motif 9739 RNA recognition motif 9739 Cysteine-rich motif following a subset of SET domains 9739 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 9743 GTPase-activator protein for Rho-like GTPases 9744 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9746 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 9748 Serine/Threonine protein kinases, catalytic domain 9752 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 9752 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 9753 leucine rich region 9754 GTPase-activator protein for Rho-like GTPases 9754 in StAR and phosphatidylcholine transfer protein 9757 PHD zinc finger 9757 "FY-rich" domain, C-terminal region 9757 "FY-rich" domain, N-terminal region 9758 Band 4.1 homologues 9758 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9760 high mobility group 9766 Domain abundant in complement control proteins 9771 Guanine nucleotide exchange factor for Ras-like GTPases 9771 Guanine nucleotide exchange factor for Ras-like small GTPases 9779 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 9782 U1-like zinc finger 9782 RNA recognition motif 9783 Protein kinase C conserved region 2 (CalB) 9784 Band 4.1 homologues 9795 Domain associated with PX domains 9806 Kazal type serine protease inhibitors 9815 Putative GTP-ase activating proteins for the small GTPase, ARF 9815 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins 9815 Putative GTP-ase activating proteins for the small GTPase, ARF 9815 Putative GTP-ase activating proteins for the small GTPase, ARF 9815 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins 9815 Putative GTP-ase activating proteins for the small GTPase, ARF 9817 Kelch domain 9824 GTPase-activator protein for Rho-like GTPases 9826 Regulator of G protein signalling domain 9826 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9826 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9828 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9829 DnaJ molecular chaperone homology domain 9830 associated with SPRY domains 9830 Domain in SPla and the RYanodine Receptor. 9830 associated with SPRY domains 9830 Domain in SPla and the RYanodine Receptor. 9830 associated with SPRY domains 9830 Domain in SPla and the RYanodine Receptor. 9833 Serine/Threonine protein kinases, catalytic domain 9839 Homeodomain 9842 domain involved in Ras-like GTPase signaling 9842 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 9842 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 9846 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9846 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9848 Immunoglobulin 9853 Src homology 3 domains 9853 domain involved in Ras-like GTPase signaling 9855 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 9855 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9856 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 9860 Immunoglobulin 9863 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 9863 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 9866 B-Box-type zinc finger 9866 B-Box C-terminal domain 9868 Tetratricopeptide repeats 9869 Tudor domain 9869 Methyl-CpG binding domain 9869 N-terminal to some SET domains 9870 Domain Homologous to E6-AP Carboxyl Terminus with 9873 Src homology 3 domains 9874 Serine/Threonine protein kinases, catalytic domain 9877 zinc finger 9882 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 9882 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 9886 Broad-Complex, Tramtrack and Bric a brac 9886 Rho (Ras homology) subfamily of Ras-like small GTPases 9890 Acid phosphatase homologues 9891 Serine/Threonine protein kinases, catalytic domain 9898 Ubiquitin associated domain 9901 Src homology 3 domains 9901 GTPase-activator protein for Rho-like GTPases 9902 Ricin-type beta-trefoil 9902 Fibronectin type 2 domain 9902 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 9904 RNA recognition motif 9904 RNA recognition motif 9905 domain involved in Ras-like GTPase signaling 9905 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 9908 RNA recognition motif 9912 BAR domain 9912 GTPase-activator protein for Rho-like GTPases 9913 Bromodomain transcription factors and PHD domain containing proteins 9915 PAS domain 9920 Kelch domain 9921 Ring finger 9922 Sec7 domain 9922 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9924 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 9926 Phosphate acyltransferases 9928 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 9936 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 9938 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 9941 DNA/RNA non-specific endonuclease 9943 Serine/Threonine protein kinases, catalytic domain 9948 WD40 repeats 9948 WD40 repeats 9965 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 9966 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 9976 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 9984 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 9987 RNA recognition motif 9987 RNA recognition motif 9991 RNA recognition motif 9993 von Willebrand factor (vWF) type C domain 9993 Low-density lipoprotein receptor domain class A 9993 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 9996 DEAD-like helicases superfamily 9996 helicase superfamily c-terminal domain 9996 Domain of unknown function in Sec63p, Brr2p and other proteins 10000 Serine/Threonine protein kinases, catalytic domain 10000 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10000 Serine/Threonine protein kinases, catalytic domain 10000 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10006 Src homology 3 domains 10017 BCL (B-Cell lymphoma) 10019 Src homology 2 domains 10019 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10025 WD40 repeats 10040 Domain present in VPS-27, Hrs and STAM 10042 high mobility group 10044 Src homology 2 domains 10044 Guanine nucleotide exchange factor for Ras-like small GTPases 10045 Src homology 2 domains 10047 Cystatin-like domain 10048 C-terminal to LisH motif. 10048 Lissencephaly type-1-like homology motif 10048 Domain in SPla and the RYanodine Receptor. 10059 Dynamin GTPase effector domain 10069 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 10071 Domain found in sea urchin sperm protein, enterokinase, agrin 10076 Immunoglobulin 10076 Fibronectin type 3 domain 10076 Protein tyrosine phosphatase, catalytic domain 10076 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 10076 Immunoglobulin 10076 Fibronectin type 3 domain 10076 Protein tyrosine phosphatase, catalytic domain 10076 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 10076 Immunoglobulin 10076 Fibronectin type 3 domain 10076 Protein tyrosine phosphatase, catalytic domain 10076 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 10083 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10084 Domain with 2 conserved Trp (W) residues 10085 Calcium-binding EGF-like domain 10087 in StAR and phosphatidylcholine transfer protein 10087 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10087 in StAR and phosphatidylcholine transfer protein 10087 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10096 Actin 10097 Actin 10107 associated with SPRY domains 10107 Domain in SPla and the RYanodine Receptor. 10107 B-Box C-terminal domain 10107 associated with SPRY domains 10110 Serine/Threonine protein kinases, catalytic domain 10110 Serine/Threonine protein kinases, catalytic domain 10112 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 10114 Serine/Threonine protein kinases, catalytic domain 10120 Actin 10121 Actin 10125 Guanine nucleotide exchange factor for Ras-like GTPases 10125 Guanine nucleotide exchange factor for Ras-like small GTPases 10127 leucine rich region 10127 krueppel associated box 10136 Trypsin-like serine protease 10137 RNA recognition motif 10137 RNA recognition motif 10138 Zinc finger domain 10146 RNA recognition motif 10147 glycine rich nucleic binding domain 10147 Suppressor-of-White-APricot splicing regulator 10148 Fibronectin type 3 domain 10149 G-protein-coupled receptor proteolytic site domain 10151 RNA recognition motif 10152 Src homology 3 domains 10154 semaphorin domain 10154 ig-like, plexins, transcription factors 10155 bromo domain 10155 B-Box C-terminal domain 10156 Bruton's tyrosine kinase Cys-rich motif 10156 Protein kinase C conserved region 2 (CalB) 10156 GTPase-activator protein for Ras-like GTPases 10160 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 10160 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10168 leucine rich region 10174 Src homology 3 domains 10174 Sorbin homologous domain 10179 RNA recognition motif 10180 RNA recognition motif 10180 glycine rich nucleic binding domain 10181 RNA recognition motif 10181 glycine rich nucleic binding domain 10188 Src homology 3 domains 10188 Tyrosine kinase, catalytic domain 10189 RNA recognition motif 10193 Ring finger 10194 Homeodomain 10203 Domain present in hormone receptors 10205 Immunoglobulin V-Type 10205 Immunoglobulin V-Type 10206 Ring finger 10206 Ring finger 10207 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10207 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10207 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10207 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10213 JAB/MPN domain 10214 krueppel associated box 10214 krueppel associated box 10216 Somatomedin B -like domains 10216 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 10218 Fibrinogen-related domains (FReDs) 10219 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 10220 Transforming growth factor-beta (TGF-beta) family 10221 Serine/Threonine protein kinases, catalytic domain 10223 Immunoglobulin V-Type 10223 Immunoglobulin C-2 Type 10228 Helical region found in SNAREs 10235 Guanine nucleotide exchange factor for Ras-like GTPases 10235 Guanine nucleotide exchange factor for Ras-like small GTPases 10235 Guanine nucleotide exchange factor for Ras-like GTPases 10235 Guanine nucleotide exchange factor for Ras-like small GTPases 10236 RNA recognition motif 10254 Src homology 3 domains 10256 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10256 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 10261 Immunoglobulin V-Type 10265 Homeodomain 10272 Kazal type serine protease inhibitors 10273 Tetratricopeptide repeats 10273 Modified RING finger domain 10276 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 10278 Src homology 3 domains 10282 Helical region found in SNAREs 10285 Tudor domain 10288 Immunoglobulin 10290 Immunoglobulin 10291 Ubiquitin homologues 10291 Suppressor-of-White-APricot splicing regulator 10293 Ring finger 10295 Histidine kinase-like ATPases 10296 C-terminal to LisH motif. 10298 P21-Rho-binding domain 10298 Serine/Threonine protein kinases, catalytic domain 10307 Domain with 2 conserved Trp (W) residues 10307 Domain with 2 conserved Trp (W) residues 10307 Domain with 2 conserved Trp (W) residues 10307 Domain with 2 conserved Trp (W) residues 10307 Domain with 2 conserved Trp (W) residues 10307 Domain with 2 conserved Trp (W) residues 10308 krueppel associated box 10319 Laminin N-terminal domain (domain VI) 10319 Laminin-type epidermal growth factor-like domai 10321 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 10322 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 10326 Immunoglobulin 10326 Immunoglobulin C-Type 10333 Leucine rich repeat C-terminal domain 10336 Ring finger 10342 PB1 domain 10343 G-protein-coupled receptor proteolytic site domain 10344 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 10371 domain found in Plexins, Semaphorins and Integrins 10384 Immunoglobulin V-Type 10384 associated with SPRY domains 10384 Domain in SPla and the RYanodine Receptor. 10385 Immunoglobulin V-Type 10385 associated with SPRY domains 10385 associated with SPRY domains 10389 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 10394 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 10395 GTPase-activator protein for Rho-like GTPases 10395 in StAR and phosphatidylcholine transfer protein 10395 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 10395 GTPase-activator protein for Rho-like GTPases 10395 in StAR and phosphatidylcholine transfer protein 10395 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 10406 Four-disulfide core domains 10406 Four-disulfide core domains 10406 Four-disulfide core domains 10411 Guanine nucleotide exchange factor for Ras-like GTPases 10411 Guanine nucleotide exchange factor for Ras-like small GTPases 10413 Domain with 2 conserved Trp (W) residues 10417 Thrombospondin type 1 repeats 10425 In Between Ring fingers 10432 RNA recognition motif 10435 P21-Rho-binding domain 10439 Olfactomedin-like domains 10446 Immunoglobulin 10450 RNA recognition motif 10451 Src homology 2 domains 10451 Src homology 3 domains 10451 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 10451 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10457 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 10458 Src homology 3 domains 10458 Src homology 3 domains 10458 Src homology 3 domains 10461 Immunoglobulin 10461 Fibronectin type 3 domain 10461 Tyrosine kinase, catalytic domain 10468 Kazal type serine protease inhibitors 10468 Kazal type serine protease inhibitors 10475 associated with SPRY domains 10475 Domain in SPla and the RYanodine Receptor. 10480 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 10488 basic region leucin zipper 10490 Helical region found in SNAREs 10492 RNA recognition motif 10494 Serine/Threonine protein kinases, catalytic domain 10495 RNA recognition motif 10495 RNA recognition motif 10497 Protein kinase C conserved region 2 (CalB) 10499 PAS domain 10499 helix loop helix domain 10500 semaphorin domain 10500 domain found in Plexins, Semaphorins and Integrins 10501 semaphorin domain 10501 semaphorin domain 10501 semaphorin domain 10505 semaphorin domain 10505 domain found in Plexins, Semaphorins and Integrins 10507 Immunoglobulin 10507 domain found in Plexins, Semaphorins and Integrins 10509 semaphorin domain 10509 domain found in Plexins, Semaphorins and Integrins 10509 semaphorin domain 10509 domain found in Plexins, Semaphorins and Integrins 10512 Immunoglobulin C-2 Type 10512 domain found in Plexins, Semaphorins and Integrins 10516 Calcium-binding EGF-like domain 10523 glycine rich nucleic binding domain 10523 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 10529 Src homology 3 domains 10529 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 10536 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 10537 Ubiquitin homologues 10538 basic region leucin zipper 10561 domain in TBC and LysM domain containing proteins 10562 Olfactomedin-like domains 10563 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 10580 Src homology 3 domains 10580 Src homology 3 domains 10584 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 10595 Serine/Threonine protein kinases, catalytic domain 10595 domain in protein kinases, N-glycanases and other nuclear proteins 10602 P21-Rho-binding domain 10603 Src homology 2 domains 10603 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10608 helix loop helix domain 10611 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10611 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 10612 Ring finger 10612 B-Box-type zinc finger 10612 B-Box C-terminal domain 10612 Filamin-type immunoglobulin domains 10612 Ring finger 10612 B-Box-type zinc finger 10612 B-Box C-terminal domain 10612 Filamin-type immunoglobulin domains 10616 Ubiquitin homologues 10616 Ubiquitin homologues 10616 Ubiquitin homologues 10616 Ubiquitin homologues 10625 Kelch domain 10626 associated with SPRY domains 10626 Domain in SPla and the RYanodine Receptor. 10631 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 10633 Ras subfamily of RAS small GTPases 10636 Regulator of G protein signalling domain 10637 Transforming growth factor-beta (TGF-beta) family 10642 RNA recognition motif 10642 K homology RNA-binding domain 10643 RNA recognition motif 10643 K homology RNA-binding domain 10644 RNA recognition motif 10644 K homology RNA-binding domain 10645 Serine/Threonine protein kinases, catalytic domain 10645 Serine/Threonine protein kinases, catalytic domain 10645 Serine/Threonine protein kinases, catalytic domain 10645 Serine/Threonine protein kinases, catalytic domain 10645 Serine/Threonine protein kinases, catalytic domain 10645 Serine/Threonine protein kinases, catalytic domain 10645 Serine/Threonine protein kinases, catalytic domain 10648 Uteroglobin 10653 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 10655 Doublesex DNA-binding motif 10655 Doublesex DNA-binding motif 10658 RNA recognition motif 10659 RNA recognition motif 10666 Immunoglobulin 10673 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 10677 Villin headpiece domain 10677 Gelsolin homology domain 10699 Trypsin-like serine protease 10699 Low-density lipoprotein receptor domain class A 10699 Low-density lipoprotein receptor domain class A 10716 Domain first found in the mice T locus (Brachyury) protein 10725 ig-like, plexins, transcription factors 10725 ig-like, plexins, transcription factors 10725 ig-like, plexins, transcription factors 10725 ig-like, plexins, transcription factors 10725 ig-like, plexins, transcription factors 10733 Serine/Threonine protein kinases, catalytic domain 10736 Homeodomain 10738 associated with SPRY domains 10738 Domain in SPla and the RYanodine Receptor. 10739 associated with SPRY domains 10739 Domain in SPla and the RYanodine Receptor. 10746 PB1 domain 10746 Serine/Threonine protein kinases, catalytic domain 10747 Trypsin-like serine protease 10747 Calcium-binding EGF-like domain 10747 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 10747 Calcium-binding EGF-like domain 10747 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 10748 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 10749 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 10750 Src homology 2 domains 10750 Src homology 3 domains 10752 Immunoglobulin 10752 Immunoglobulin C-2 Type 10753 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 10755 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 10762 Ran-binding domain 10762 Ran-binding domain 10762 Ran-binding domain 10769 Serine/Threonine protein kinases, catalytic domain 10771 bromo domain 10772 RNA recognition motif 10772 RNA recognition motif 10780 krueppel associated box 10782 leucine rich region 10782 leucine rich region 10782 leucine rich region 10782 krueppel associated box 10783 Serine/Threonine protein kinases, catalytic domain 10788 GTPase-activator protein for Ras-like GTPases 10788 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 10794 krueppel associated box 10795 krueppel associated box 10809 in StAR and phosphatidylcholine transfer protein 10838 krueppel associated box 10846 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 10848 Src homology 3 domains 10863 ADAM Cysteine-Rich Domain 10863 Homologues of snake disintegrins 10863 ADAM Cysteine-Rich Domain 10863 Homologues of snake disintegrins 10863 ADAM Cysteine-Rich Domain 10863 Homologues of snake disintegrins 10865 ARID (A/T-rich interaction domain) domain 10868 Domain in ubiquitin-specific proteases 10871 Immunoglobulin 10877 Domain abundant in complement control proteins 10878 Domain abundant in complement control proteins 10882 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 10885 WD40 repeats 10891 RNA recognition motif 10892 Immunoglobulin 10892 Immunoglobulin 10894 Link (Hyaluronan-binding) 10902 bromo domain 10915 Domain with 2 conserved Trp (W) residues 10917 Immunoglobulin 10917 associated with SPRY domains 10917 Domain in SPla and the RYanodine Receptor. 10921 RNA recognition motif 10921 RNA recognition motif 10926 Zinc finger in DBF-like proteins 10928 GTPase-activator protein for Rho-like GTPases 10929 RNA recognition motif 10933 Chromatin organization modifier domain 10938 Eps15 homology domain 10942 Trypsin-like serine protease 10942 Trypsin-like serine protease 10942 Trypsin-like serine protease 10943 Chromatin organization modifier domain 10943 Chromatin organization modifier domain 10948 in StAR and phosphatidylcholine transfer protein 10949 RNA recognition motif 10953 Tetratricopeptide repeats 10966 Rab subfamily of small GTPases 10966 suppressors of cytokine signalling 10979 Band 4.1 homologues 10979 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 10980 JAB/MPN domain 10981 Rab subfamily of small GTPases 10987 JAB/MPN domain 10990 Immunoglobulin 10992 Basic domain in HLH proteins of MYOD family 10992 proline-rich domain in spliceosome associated proteins 10992 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 11005 Kazal type serine protease inhibitors 11010 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 11011 Serine/Threonine protein kinases, catalytic domain 11012 Trypsin-like serine protease 11012 Trypsin-like serine protease 11016 basic region leucin zipper 11021 Rab subfamily of small GTPases 11022 Tudor domain 11022 K homology RNA-binding domain 11024 Immunoglobulin 11026 Immunoglobulin 11027 Immunoglobulin 11030 RNA recognition motif 11033 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 11040 Serine/Threonine protein kinases, catalytic domain 11043 Ring finger 11043 B-Box C-terminal domain 11043 Fibronectin type 3 domain 11043 Domain in SPla and the RYanodine Receptor. 11043 Ring finger 11043 B-Box C-terminal domain 11043 Fibronectin type 3 domain 11043 Domain in SPla and the RYanodine Receptor. 11052 RNA recognition motif 11059 Domain with 2 conserved Trp (W) residues 11059 Domain Homologous to E6-AP Carboxyl Terminus with 11060 Domain with 2 conserved Trp (W) residues 11060 Protein kinase C conserved region 2 (CalB) 11060 Domain Homologous to E6-AP Carboxyl Terminus with 11063 high mobility group 11063 high mobility group 11065 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 11065 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 11065 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 11065 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 11065 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 11066 RNA recognition motif 11066 RNA recognition motif 11066 RNA recognition motif 11066 RNA recognition motif 11068 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the t 11069 Guanine nucleotide exchange factor for Ras-like GTPases 11069 Guanine nucleotide exchange factor for Ras-like small GTPases 11072 Dual specificity phosphatase, catalytic domain 11074 Ring finger 11074 Ring finger 11078 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 11078 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 11081 Leucine rich repeat N-terminal domain 11085 ADAM Cysteine-Rich Domain 11085 Homologues of snake disintegrins 11086 ADAM Cysteine-Rich Domain 11086 Homologues of snake disintegrins 11086 ADAM Cysteine-Rich Domain 11086 Homologues of snake disintegrins 11086 ADAM Cysteine-Rich Domain 11086 Homologues of snake disintegrins 11093 Thrombospondin type 1 repeats 11093 Thrombospondin type 1 repeats 11093 Thrombospondin type 1 repeats 11095 ADAM Cysteine-Rich Domain 11095 Thrombospondin type 1 repeats 11097 zinc finger 11098 Trypsin-like serine protease 11099 Band 4.1 homologues 11099 Protein tyrosine phosphatase, catalytic domain 11100 Domain in SPla and the RYanodine Receptor. 11100 Domain in SPla and the RYanodine Receptor. 11100 Domain in SPla and the RYanodine Receptor. 11105 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 11107 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 11108 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 11113 Serine/Threonine protein kinases, catalytic domain 11113 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 11113 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 11113 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 11113 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 11113 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 11113 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 11117 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 11118 Immunoglobulin V-Type 11119 Immunoglobulin V-Type 11119 associated with SPRY domains 11119 Domain in SPla and the RYanodine Receptor. 11120 Immunoglobulin V-Type 11120 associated with SPRY domains 11120 Domain in SPla and the RYanodine Receptor. 11120 Immunoglobulin V-Type 11122 Fibronectin type 3 domain 11122 Protein tyrosine phosphatase, catalytic domain 11122 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 11122 Fibronectin type 3 domain 11122 Protein tyrosine phosphatase, catalytic domain 11122 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 11124 UAS domain 11124 Domain present in ubiquitin-regulatory proteins 11124 UAS domain 11124 Domain present in ubiquitin-regulatory proteins 11131 calpain_III domain 11131 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 calpain_III domain 11132 calpain_III domain 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 calpain_III domain 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 calpain_III domain 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 calpain_III domain 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 calpain_III domain 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11132 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 11139 Immunoglobulin 11139 Fibronectin type 3 domain 11139 Serine/Threonine protein kinases, catalytic domain 11139 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 11141 Immunoglobulin 11148 Immunoglobulin V-Type 11155 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 11155 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 11158 Rab subfamily of small GTPases 11159 Rab subfamily of small GTPases 11159 Rab subfamily of small GTPases 11167 Kazal type serine protease inhibitors 11169 high mobility group 11172 Insulin / insulin-like growth factor / relaxin family. 11173 ADAM Cysteine-Rich Domain 11173 Thrombospondin type 1 repeats 11174 Thrombospondin type 1 repeats 11176 bromo domain 11176 Methyl-CpG binding domain 11177 bromo domain 11177 bromo domain 11183 Serine/Threonine protein kinases, catalytic domain 11183 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 11184 Serine/Threonine protein kinases, catalytic domain 11184 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 11187 Armadillo/beta-catenin-like repeats 11189 RNA recognition motif 11193 U1-like zinc finger 11193 Domain with 2 conserved Trp (W) residues 11196 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 11197 Wnt-inhibitory factor-1 like domain 11200 Serine/Threonine protein kinases, catalytic domain 11200 Serine/Threonine protein kinases, catalytic domain 11202 Trypsin-like serine protease 11202 Trypsin-like serine protease 11202 Trypsin-like serine protease 11211 Frizzled 11214 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 11214 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 11214 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 11216 Regulator of G protein signalling domain 11219 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11219 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11219 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11219 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11221 Rhodanese Homology Domain 11226 Ricin-type beta-trefoil 11227 Ricin-type beta-trefoil 11227 Ricin-type beta-trefoil 11228 Ras association (RalGDS/AF-6) domain 11231 Domain of unknown function in Sec63p, Brr2p and other proteins 11236 Ring finger 11244 Homeodomain 11252 Src homology 3 domains 11262 bromo domain 11266 Dual specificity phosphatase, catalytic domain 11275 Kelch domain 11275 Broad-Complex, Tramtrack and Bric a brac 11276 Eps15 homology domain 11276 Eps15 homology domain 11276 Eps15 homology domain 11277 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11277 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11277 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11277 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 11281 Found in Pit-Oct-Unc transcription factors 11302 Tyrosine kinase, catalytic domain 11308 Src homology 3 domains 11314 Immunoglobulin 11314 Immunoglobulin V-Type 11326 Immunoglobulin V-Type 11326 Immunoglobulin C-2 Type 11329 Extension to Ser/Thr-type protein kinases 11329 Serine/Threonine protein kinases, catalytic domain 11330 Trypsin-like serine protease 11338 RNA recognition motif 11344 Actin depolymerisation factor/cofilin -like domains 11350 Tyrosine kinase, catalytic domain 11350 erine/Threonine protein kinases, catalytic domain 11350 Serine/Threonine protein kinases, catalytic domain 11352 Src homology 3 domains 11352 Src homology 2 domains 11352 Tyrosine kinase, catalytic domain 11352 erine/Threonine protein kinases, catalytic domain 11352 Serine/Threonine protein kinases, catalytic domain 11354 Uteroglobin 11426 Spectrin repeats 11426 Spectrin repeats 11426 Calponin homology domain 11431 Low molecular weight phosphatase family 11434 Trypsin-like serine protease 11450 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 11477 GS motif 11479 Tyrosine kinase, catalytic domain 11479 erine/Threonine protein kinases, catalytic domain 11479 Serine/Threonine protein kinases, catalytic domain 11482 GS motif 11487 Homologues of snake disintegrins 11488 ADAM Cysteine-Rich Domain 11488 Homologues of snake disintegrins 11489 ADAM Cysteine-Rich Domain 11489 Homologues of snake disintegrins 11490 ADAM Cysteine-Rich Domain 11490 Homologues of snake disintegrins 11491 Homologues of snake disintegrins 11492 ADAM Cysteine-Rich Domain 11492 Homologues of snake disintegrins 11495 ADAM Cysteine-Rich Domain 11495 Homologues of snake disintegrins 11496 ADAM Cysteine-Rich Domain 11496 Homologues of snake disintegrins 11497 ADAM Cysteine-Rich Domain 11497 Homologues of snake disintegrins 11498 ADAM Cysteine-Rich Domain 11498 Homologues of snake disintegrins 11499 ADAM Cysteine-Rich Domain 11499 Homologues of snake disintegrins 11500 ADAM Cysteine-Rich Domain 11500 Homologues of snake disintegrins 11501 ADAM Cysteine-Rich Domain 11501 Homologues of snake disintegrins 11502 ADAM Cysteine-Rich Domain 11502 Homologues of snake disintegrins 11504 ADAM Cysteine-Rich Domain 11504 Thrombospondin type 1 repeats 11517 Domain present in hormone receptors 11537 Trypsin-like serine protease 11538 Homeodomain 11567 Gelsolin homology domain 11568 Zn_pept domain 11571 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 11572 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 11576 serum albumin 11576 serum albumin 11595 Immunoglobulin V-Type 11595 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 11596 Immunoglobulin 11596 Immunoglobulin C-2 Type 11596 Immunoglobulin 11596 Immunoglobulin C-2 Type 11596 Immunoglobulin 11596 Immunoglobulin C-2 Type 11600 Fibrinogen-related domains (FReDs) 11601 Fibrinogen-related domains (FReDs) 11602 Fibrinogen-related domains (FReDs) 11603 Calcium-binding EGF-like domain 11603 Epidermal growth factor-like domain 11603 Kazal type serine protease inhibitors 11603 Laminin-type epidermal growth factor-like domai 11603 Domain found in sea urchin sperm protein, enterokinase, agrin 11614 Ligand binding domain of hormone receptors 11624 PAS domain 11630 Beta/gamma crystallins 11630 Ricin-type beta-trefoil 11640 K homology RNA-binding domain 11651 Serine/Threonine protein kinases, catalytic domain 11652 Serine/Threonine protein kinases, catalytic domain 11652 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 11657 serum albumin 11658 Immunoglobulin 11658 Immunoglobulin 11658 Immunoglobulin C-2 Type 11682 Tyrosine kinase, catalytic domain 11684 Lipoxygenase homology 2 (beta barrel) domain 11685 Lipoxygenase homology 2 (beta barrel) domain 11687 Lipoxygenase homology 2 (beta barrel) domain 11688 Lipoxygenase homology 2 (beta barrel) domain 11699 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 11705 Transforming growth factor-beta (TGF-beta) family 11705 Transforming growth factor-beta (TGF-beta) family 11733 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11735 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 11749 Annexin repeats 11784 Domain present in PSD-95, Dlg, and ZO-1/2 11784 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 11784 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 11785 Domain with 2 conserved Trp (W) residues 11787 Domain with 2 conserved Trp (W) residues 11787 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 11789 Armadillo/beta-catenin-like repeats 11790 Immunoglobulin 11796 Baculoviral inhibition of apoptosis protein repeat 11797 Baculoviral inhibition of apoptosis protein repeat 11798 Baculoviral inhibition of apoptosis protein repeat 11799 Baculoviral inhibition of apoptosis protein repeat 11801 Scavenger receptor Cys-rich 11804 amyloid A4 11808 DNA Topoisomerase I (eukaryota) 11818 Domain abundant in complement control proteins 11840 ARF-like small GTPases 11841 ARF-like small GTPases 11842 ARF-like small GTPases 11843 ARF-like small GTPases 11844 ARF-like small GTPases 11845 ARF-like small GTPases 11848 Rho (Ras homology) subfamily of Ras-like small GTPases 11852 Rho (Ras homology) subfamily of Ras-like small GTPases 11853 Rho (Ras homology) subfamily of Ras-like small GTPases 11854 Rho (Ras homology) subfamily of Ras-like small GTPases 11855 Contains two conserved F residues 11855 GTPase-activator protein for Rho-like GTPases 11856 GTPase-activator protein for Rho-like GTPases 11858 Rho (Ras homology) subfamily of Ras-like small GTPases 11863 PAS domain 11863 helix loop helix domain 11864 PAS domain 11865 PAS domain 11877 Armadillo/beta-catenin-like repeats 11889 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 11899 membrane-attack complex / perforin 11909 basic region leucin zipper 11909 basic region leucin zipper 11910 basic region leucin zipper 11911 basic region leucin zipper 11920 Phosphoinositide 3-kinase, catalytic domain 11921 helix loop helix domain 11922 helix loop helix domain 11990 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 11990 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 11991 RNA recognition motif 11991 RNA recognition motif 11994 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12005 Domain present in Dishevelled and axin 12006 Domain present in Dishevelled and axin 12006 Regulator of G protein signalling domain 12010 Immunoglobulin C-Type 12013 basic region leucin zipper 12014 basic region leucin zipper 12017 Ubiquitin homologues 12017 BAG domains, present in regulator of Hsp70 proteins 12021 Ring finger 12021 breast cancer carboxy-terminal domain 12032 Immunoglobulin V-Type 12032 Domain abundant in complement control proteins 12032 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 12034 prohibitin homologues 12034 prohibitin homologues 12043 BH4 Bcl-2 homology region 4 12043 BH4 Bcl-2 homology region 4 12048 BH4 Bcl-2 homology region 4 12049 BCL (B-Cell lymphoma) 12050 BH4 Bcl-2 homology region 4 12068 Helical region found in SNAREs 12095 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 12096 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 12097 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 12142 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 12143 Tyrosine kinase, catalytic domain 12153 Calcium-binding EGF-like domain 12153 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 12153 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 12154 Transforming growth factor-beta (TGF-beta) family 12155 Transforming growth factor-beta (TGF-beta) family 12156 Transforming growth factor-beta (TGF-beta) family 12159 Transforming growth factor-beta (TGF-beta) family 12160 Transforming growth factor-beta (TGF-beta) family 12161 Transforming growth factor-beta (TGF-beta) family 12162 Transforming growth factor-beta (TGF-beta) family 12163 Transforming growth factor-beta (TGF-beta) family 12164 Transforming growth factor-beta (TGF-beta) family 12164 Transforming growth factor-beta (TGF-beta) family 12165 Transforming growth factor-beta (TGF-beta) family 12165 Transforming growth factor-beta (TGF-beta) family 12169 Src homology 2 domains 12169 Tyrosine kinase, catalytic domain 12169 Bruton's tyrosine kinase Cys-rich motif 12169 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 12175 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 12180 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 12192 zinc finger 12215 Immunoglobulin 12226 tob/btg1 family 12229 Src homology 2 domains 12229 Tyrosine kinase, catalytic domain 12229 Bruton's tyrosine kinase Cys-rich motif 12229 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 12231 Immunoglobulin V-Type 12231 associated with SPRY domains 12231 Domain in SPla and the RYanodine Receptor. 12234 A Receptor for Ubiquitination Targets 12235 Serine/Threonine protein kinases, catalytic domain 12235 Tyrosine kinase, catalytic domain 12235 erine/Threonine protein kinases, catalytic domain 12235 Serine/Threonine protein kinases, catalytic domain 12235 Tyrosine kinase, catalytic domain 12235 erine/Threonine protein kinases, catalytic domain 12235 Serine/Threonine protein kinases, catalytic domain 12236 erine/Threonine protein kinases, catalytic domain 12236 Serine/Threonine protein kinases, catalytic domain 12258 SERine Proteinase INhibitors 12259 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 12260 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 12262 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 12263 Trypsin-like serine protease 12263 Domain abundant in complement control proteins 12263 Trypsin-like serine protease 12263 von Willebrand factor (vWF) type A domain 12263 Domain abundant in complement control proteins 12263 Trypsin-like serine protease 12263 von Willebrand factor (vWF) type A domain 12263 Domain abundant in complement control proteins 12265 Leucine rich repeat, ribonuclease inhibitor type 12269 Domain abundant in complement control proteins 12274 Thrombospondin type 1 repeats 12274 Low-density lipoprotein receptor domain class A 12293 von Willebrand factor (vWF) type A domain 12294 von Willebrand factor (vWF) type A domain 12295 Src homology 3 domains 12295 Src homology 3 domains 12295 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 12296 Src homology 3 domains 12296 Src homology 3 domains 12296 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 12298 Src homology 3 domains 12305 Tyrosine kinase, catalytic domain 12305 Tyrosine kinase, catalytic domain 12305 erine/Threonine protein kinases, catalytic domain 12305 Serine/Threonine protein kinases, catalytic domain 12305 Coagulation factor 5/8 C-terminal domain, discoidin domain 12306 Annexin repeats 12310 calcitonin 12310 calcitonin 12311 Domain present in hormone receptors 12311 Domain present in hormone receptors 12322 Serine/Threonine protein kinases, catalytic domain 12323 Serine/Threonine protein kinases, catalytic domain 12325 Serine/Threonine protein kinases, catalytic domain 12325 Tyrosine kinase, catalytic domain 12325 erine/Threonine protein kinases, catalytic domain 12325 Serine/Threonine protein kinases, catalytic domain 12326 Serine/Threonine protein kinases, catalytic domain 12326 Tyrosine kinase, catalytic domain 12326 erine/Threonine protein kinases, catalytic domain 12326 Serine/Threonine protein kinases, catalytic domain 12332 Gelsolin homology domain 12334 calpain_III domain 12334 Calpain-like thiol protease family 12334 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 12337 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 12337 calpain_III domain 12337 Calpain-like thiol protease family 12337 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 12338 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 12339 calpain_III domain 12339 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 12361 Src homology 3 domains 12361 Serine/Threonine protein kinases, catalytic domain 12361 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 12361 Serine/Threonine protein kinases, catalytic domain 12362 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12363 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12364 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12365 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12366 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12367 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12368 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12369 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12370 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12371 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 12388 Armadillo/beta-catenin-like repeats 12388 Armadillo/beta-catenin-like repeats 12395 TAF homology 12398 TAF homology 12402 Ring finger 12402 Ubiquitin associated domain 12405 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 12406 SERine Proteinase INhibitors 12411 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 12411 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 12449 A Receptor for Ubiquitination Targets 12454 domain present in cyclins, TFIIB and Retinoblastoma 12477 Immunoglobulin V-Type 12478 Immunoglobulin 12479 Immunoglobulin C-Type 12480 Immunoglobulin C-Type 12483 Immunoglobulin 12483 Immunoglobulin C-2 Type 12483 Immunoglobulin 12483 Immunoglobulin C-2 Type 12487 Immunoglobulin V-Type 12488 Src homology 3 domains 12489 Immunoglobulin 12500 Immunoreceptor tyrosine-based activation motif 12501 Immunoglobulin C-2 Type 12502 Immunoglobulin C-2 Type 12504 Immunoglobulin 12505 Link (Hyaluronan-binding) 12505 Link (Hyaluronan-binding) 12506 Immunoglobulin 12509 Ly-6 antigen / uPA receptor -like domain 12509 Ly-6 antigen / uPA receptor -like domain 12511 Scavenger receptor Cys-rich 12515 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 12516 Immunoglobulin 12517 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 12518 Immunoglobulin 12519 Immunoglobulin 12519 Immunoglobulin 12522 Immunoglobulin 12524 Immunoglobulin V-Type 12525 Immunoglobulin 12525 Immunoglobulin V-Type 12526 Immunoglobulin V-Type 12534 Serine/Threonine protein kinases, catalytic domain 12536 Serine/Threonine protein kinases, catalytic domain 12537 Serine/Threonine protein kinases, catalytic domain 12540 Rho (Ras homology) subfamily of Ras-like small GTPases 12545 Serine/Threonine protein kinases, catalytic domain 12549 GTPase-activator protein for Rho-like GTPases 12550 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12551 Cadherin repeats 12551 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12552 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12554 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12555 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12556 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12557 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12558 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12561 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12562 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12563 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12564 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12566 Serine/Threonine protein kinases, catalytic domain 12567 Serine/Threonine protein kinases, catalytic domain 12568 Serine/Threonine protein kinases, catalytic domain 12571 Serine/Threonine protein kinases, catalytic domain 12572 Tyrosine kinase, catalytic domain 12572 erine/Threonine protein kinases, catalytic domain 12572 Serine/Threonine protein kinases, catalytic domain 12587 Src homology 3 domains 12593 Chromatin organization modifier domain 12606 basic region leucin zipper 12608 basic region leucin zipper 12609 basic region leucin zipper 12611 basic region leucin zipper 12614 Laminin G domain 12614 Calcium-binding EGF-like domain 12614 Domain present in hormone receptors 12614 G-protein-coupled receptor proteolytic site domain 12614 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12615 Histone H3 12616 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 12628 Domain abundant in complement control proteins 12630 Scavenger receptor Cys-rich 12630 Trypsin-like serine protease 12630 factor I membrane attack complex 12631 Actin depolymerisation factor/cofilin -like domains 12631 Actin depolymerisation factor/cofilin -like domains 12632 Actin depolymerisation factor/cofilin -like domains 12640 Glycoprotein hormone alpha chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 12643 Leucine rich repeat N-terminal domain 12649 Serine/Threonine protein kinases, catalytic domain 12654 Glyco_18 domain 12654 Glyco_18 domain 12655 Glyco_18 domain 12659 Glyco_18 domain 12661 Immunoglobulin 12661 Immunoglobulin C-2 Type 12661 Fibronectin type 3 domain 12667 Domain in SOG (short gastrulation protein) and chordin 12675 Serine/Threonine protein kinases, catalytic domain 12695 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 12695 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 12696 RNA recognition motif 12700 Src homology 2 domains 12700 suppressors of cytokine signalling 12702 Src homology 2 domains 12702 suppressors of cytokine signalling 12703 Src homology 2 domains 12703 suppressors of cytokine signalling 12704 Serine/Threonine protein kinases, catalytic domain 12704 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 12704 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 12704 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 12704 Tyrosine kinase, catalytic domain 12704 Extension to Ser/Thr-type protein kinases 12704 erine/Threonine protein kinases, catalytic domain 12704 Serine/Threonine protein kinases, catalytic domain 12704 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 12704 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 12704 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 12722 von Willebrand factor (vWF) type A domain 12748 Serine/Threonine protein kinases, catalytic domain 12750 Serine/Threonine protein kinases, catalytic domain 12753 PAS domain 12753 helix loop helix domain 12753 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 12753 PAS domain 12753 helix loop helix domain 12753 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 12759 CLUSTERIN Beta chain 12759 CLUSTERIN alpha chain 12762 Trypsin-like serine protease 12788 Cyclic nucleotide-monophosphate binding domain 12790 Cyclic nucleotide-monophosphate binding domain 12795 Serine/Threonine protein kinases, catalytic domain 12804 Immunoglobulin C-2 Type 12804 Fibronectin type 3 domain 12805 Immunoglobulin 12805 Immunoglobulin C-2 Type 12814 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 12815 Fibrillar collagens C-terminal domain 12815 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 12815 Fibrillar collagens C-terminal domain 12816 Fibronectin type 3 domain 12818 Fibronectin type 3 domain 12818 Thrombospondin N-terminal -like domains 12818 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 12824 Fibrillar collagens C-terminal domain 12825 Fibrillar collagens C-terminal domain 12826 C-terminal tandem repeated domain in type 4 procollagens 12828 C-terminal tandem repeated domain in type 4 procollagens 12829 C-terminal tandem repeated domain in type 4 procollagens 12830 C-terminal tandem repeated domain in type 4 procollagens 12830 C-terminal tandem repeated domain in type 4 procollagens 12831 Fibrillar collagens C-terminal domain 12831 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 12832 Fibrillar collagens C-terminal domain 12832 Fibrillar collagens C-terminal domain 12832 von Willebrand factor (vWF) type C domain 12833 von Willebrand factor (vWF) type A domain 12834 von Willebrand factor (vWF) type A domain 12834 von Willebrand factor (vWF) type A domain 12835 von Willebrand factor (vWF) type A domain 12835 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 12835 Fibronectin type 3 domain 12835 BPTI/Kunitz family of serine protease inhibitors 12835 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 12836 Fibronectin type 3 domain 12836 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 12842 Fibrillar collagens C-terminal domain 12842 von Willebrand factor (vWF) type C domain 12843 Fibrillar collagens C-terminal domain 12845 Calcium-binding EGF-like domain 12847 WD40 repeats 12874 Zn_pept domain 12877 RNA recognition motif 12891 von Willebrand factor (vWF) type A domain 12902 Domain abundant in complement control proteins 12905 Caspase recruitment domain 12905 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 12909 DNA-directed RNA-polymerase II subunit 12913 basic region leucin zipper 12915 basic region leucin zipper 12921 Domain present in hormone receptors 12922 Domain present in hormone receptors 12927 Src homology 3 domains 12928 Src homology 3 domains 12929 Src homology 3 domains 12931 Fibronectin type 3 domain 12936 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12937 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12939 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12939 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12941 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12941 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12942 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12943 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 12945 Scavenger receptor Cys-rich 12945 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 12945 Zona pellucida (ZP) domain 12945 Scavenger receptor Cys-rich 12945 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 12945 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 12946 Domain abundant in complement control proteins 12950 Immunoglobulin V-Type 12978 Immunoglobulin 12978 Tyrosine kinase, catalytic domain 12988 Src homology 2 domains 12988 Src homology 3 domains 12988 Tyrosine kinase, catalytic domain 12995 Serine/Threonine protein kinases, catalytic domain 12995 Tyrosine kinase, catalytic domain 12995 erine/Threonine protein kinases, catalytic domain 12995 Serine/Threonine protein kinases, catalytic domain 13003 Immunoglobulin V-Type 13003 Link (Hyaluronan-binding) 13003 Calcium-binding EGF-like domain 13003 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 13004 Link (Hyaluronan-binding) 13004 Calcium-binding EGF-like domain 13004 Domain abundant in complement control proteins 13004 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 13010 Cystatin-like domain 13011 Cystatin-like domain 13012 Cystatin-like domain 13012 Cystatin-like domain 13013 Cystatin-like domain 13035 Trypsin-like serine protease 13038 Papain family cysteine protease 13039 Papain family cysteine protease 13040 Papain family cysteine protease 13043 Src homology 3 domains 13052 Immunoglobulin 13052 Immunoglobulin V-Type 13131 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 13136 Domain abundant in complement control proteins 13137 Domain abundant in complement control proteins 13143 Serine/Threonine protein kinases, catalytic domain 13143 RIO-like kinase 13143 Tyrosine kinase, catalytic domain 13143 erine/Threonine protein kinases, catalytic domain 13143 Serine/Threonine protein kinases, catalytic domain 13144 Serine/Threonine protein kinases, catalytic domain 13164 RNA recognition motif 13169 Src homology 3 domains 13169 Actin depolymerisation factor/cofilin -like domains 13170 basic region leucin zipper 13172 Homeodomain 13175 Domain in the Doublecortin (DCX) gene product 13175 Serine/Threonine protein kinases, catalytic domain 13176 Immunoglobulin 13176 Immunoglobulin C-2 Type 13176 Fibronectin type 3 domain 13193 Domain in the Doublecortin (DCX) gene product 13196 ankyrin repeats 13196 Src homology 3 domains 13196 Putative GTP-ase activating proteins for the small GTPase, ARF 13196 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 13206 DEAD-like helicases superfamily 13206 helicase superfamily c-terminal domain 13209 DEAD-like helicases superfamily 13209 helicase superfamily c-terminal domain 13211 Double-stranded RNA binding motif 13356 von Willebrand factor (vWF) type C domain 13356 Low-density lipoprotein receptor domain class A 13356 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 13367 Formin Homology 2 Domain 13383 Src homology 3 domains 13383 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 13383 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 13384 Src homology 3 domains 13384 domain in receptor targeting proteins Lin-2 and Lin-7 13384 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 13384 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 13385 Src homology 3 domains 13385 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 13385 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 13388 Calcium-binding EGF-like domain 13400 Serine/Threonine protein kinases, catalytic domain 13401 WD40 repeats 13405 Spectrin repeats 13405 Domain with 2 conserved Trp (W) residues 13418 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 13419 deoxyribonuclease I 13421 deoxyribonuclease I 13424 ATPases associated with a variety of cellular activities 13429 Dynamin, GTPase 13429 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 13446 Protein kinase C conserved region 2 (CalB) 13448 Phosphotyrosine-binding domain (IRS1-like) 13449 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 13497 Spectrin repeats 13497 Domain with 2 conserved Trp (W) residues 13497 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 13507 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 13508 Immunoglobulin 13508 Immunoglobulin C-2 Type 13511 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 13512 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 13512 Cadherin repeats 13512 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 13518 Plectin repeat 13518 Spectrin repeats 13518 Spectrin repeats 13518 Spectrin repeats 13522 ADAM Cysteine-Rich Domain 13522 Homologues of snake disintegrins 13524 ADAM Cysteine-Rich Domain 13524 Homologues of snake disintegrins 13525 ADAM Cysteine-Rich Domain 13525 Homologues of snake disintegrins 13526 ADAM Cysteine-Rich Domain 13526 Homologues of snake disintegrins 13548 Serine/Threonine protein kinases, catalytic domain 13548 Tyrosine kinase, catalytic domain 13548 erine/Threonine protein kinases, catalytic domain 13548 Serine/Threonine protein kinases, catalytic domain 13548 Tyrosine kinase, catalytic domain 13548 erine/Threonine protein kinases, catalytic domain 13548 Serine/Threonine protein kinases, catalytic domain 13549 Serine/Threonine protein kinases, catalytic domain 13586 Pancreatic ribonuclease 13586 Pancreatic ribonuclease 13587 Pancreatic ribonuclease 13590 Transforming growth factor-beta (TGF-beta) family 13591 helix loop helix domain 13602 Follistatin-N-terminal domain-like 13605 breast cancer carboxy-terminal domain 13605 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 13607 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 13612 Calcium-binding EGF-like domain 13612 Coagulation factor 5/8 C-terminal domain, discoidin domain 13614 Endothelin 13616 Endothelin 13644 Src homology 3 domains 13645 Calcium-binding EGF-like domain 13645 Low-density lipoprotein-receptor YWTD domain 13647 Trypsin-like serine protease 13648 Trypsin-like serine protease 13660 Eps15 homology domain 13661 SAM / Pointed domain 13661 erythroblast transformation specific domain 13666 Serine/Threonine protein kinases, catalytic domain 13706 Trypsin-like serine protease 13709 erythroblast transformation specific domain 13710 SAM / Pointed domain 13710 erythroblast transformation specific domain 13711 SAM / Pointed domain 13711 erythroblast transformation specific domain 13712 erythroblast transformation specific domain 13723 Immunoglobulin 13726 in nuclear membrane-associated proteins 13728 Serine/Threonine protein kinases, catalytic domain 13733 Calcium-binding EGF-like domain 13733 G-protein-coupled receptor proteolytic site domain 13796 Homeodomain 13803 Kelch domain 13804 DNA/RNA non-specific endonuclease 13805 Zona pellucida (ZP) domain 13813 Domain first found in the mice T locus (Brachyury) protein 13819 PAS domain 13829 Villin headpiece domain 13835 Fibronectin type 3 domain 13835 Tyrosine kinase, catalytic domain 13835 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13836 Fibronectin type 3 domain 13836 Tyrosine kinase, catalytic domain 13836 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13837 Fibronectin type 3 domain 13837 Tyrosine kinase, catalytic domain 13837 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13837 Fibronectin type 3 domain 13837 Tyrosine kinase, catalytic domain 13837 Ephrin receptor ligand binding domain 13837 erine/Threonine protein kinases, catalytic domain 13837 Serine/Threonine protein kinases, catalytic domain 13837 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 13838 Fibronectin type 3 domain 13838 Tyrosine kinase, catalytic domain 13839 Fibronectin type 3 domain 13839 Tyrosine kinase, catalytic domain 13839 Sterile alpha motif 13839 Fibronectin type 3 domain 13839 Tyrosine kinase, catalytic domain 13839 Ephrin receptor ligand binding domain 13839 erine/Threonine protein kinases, catalytic domain 13840 Fibronectin type 3 domain 13840 Tyrosine kinase, catalytic domain 13840 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13841 Fibronectin type 3 domain 13841 Tyrosine kinase, catalytic domain 13841 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13841 Sterile alpha motif 13841 Fibronectin type 3 domain 13841 Tyrosine kinase, catalytic domain 13841 Ephrin receptor ligand binding domain 13841 erine/Threonine protein kinases, catalytic domain 13841 Serine/Threonine protein kinases, catalytic domain 13841 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 13842 Fibronectin type 3 domain 13842 Tyrosine kinase, catalytic domain 13842 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13845 Sterile alpha motif 13845 Fibronectin type 3 domain 13845 Tyrosine kinase, catalytic domain 13845 Ephrin receptor ligand binding domain 13845 erine/Threonine protein kinases, catalytic domain 13845 Serine/Threonine protein kinases, catalytic domain 13845 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 13846 Fibronectin type 3 domain 13846 Tyrosine kinase, catalytic domain 13846 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13846 Sterile alpha motif 13846 Fibronectin type 3 domain 13846 Tyrosine kinase, catalytic domain 13846 Ephrin receptor ligand binding domain 13846 erine/Threonine protein kinases, catalytic domain 13846 Serine/Threonine protein kinases, catalytic domain 13846 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 13848 Tyrosine kinase, catalytic domain 13848 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 13852 Syntaxin N-terminal domain 13852 Syntaxin N-terminal domain 13852 Helical region found in SNAREs 13855 Epsin N-terminal homology (ENTH) domain 13855 Domain present in VPS-27, Hrs and STAM 13855 Epsin N-terminal homology (ENTH) domain 13857 Fibronectin type 3 domain 13858 Eps15 homology domain 13859 Eps15 homology domain 13860 Src homology 3 domains 13860 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 13866 Furin-like repeats 13866 Tyrosine kinase, catalytic domain 13866 erine/Threonine protein kinases, catalytic domain 13867 Furin-like repeats 13867 Tyrosine kinase, catalytic domain 13867 erine/Threonine protein kinases, catalytic domain 13867 Serine/Threonine protein kinases, catalytic domain 13869 Furin-like repeats 13871 DEAD-like helicases superfamily 13876 SAM / Pointed domain 13876 erythroblast transformation specific domain 13915 K homology RNA-binding domain 13924 Fibronectin type 3 domain 13924 Protein tyrosine phosphatase, catalytic domain 13990 DEAD-like helicases superfamily 13990 helicase superfamily c-terminal domain 13998 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 13998 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 14000 Ribonuclease III family 14007 RNA recognition motif 14012 Immunoglobulin V-Type 14020 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 14027 Plectin repeat 14030 RNA recognition motif 14038 Four-disulfide core domains 14058 Trypsin-like serine protease 14058 Calcium-binding EGF-like domain 14058 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 14060 Domain abundant in complement control proteins 14061 Kringle domain 14061 Trypsin-like serine protease 14061 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 14068 Trypsin-like serine protease 14068 Calcium-binding EGF-like domain 14068 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 14071 Trypsin-like serine protease 14071 Calcium-binding EGF-like domain 14071 Domain containing Gla (gamma-carboxyglutamate) residues 14071 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 14082 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 14083 Band 4.1 homologues 14083 Tyrosine kinase, catalytic domain 14084 UAS domain 14084 Domain present in ubiquitin-regulatory proteins 14102 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 14105 RNA recognition motif 14106 FORKHEAD 14107 Cadherin repeats 14107 Laminin G domain 14107 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 14109 Ubiquitin homologues 14114 Calcium-binding EGF-like domain 14115 Calcium-binding EGF-like domain 14118 Calcium-binding EGF-like domain 14125 Immunoglobulin 14128 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 14129 Immunoglobulin C-2 Type 14130 Immunoglobulin 14131 Immunoglobulin 14132 Immunoglobulin C-Type 14133 Fibrinogen-related domains (FReDs) 14134 Fibrinogen-related domains (FReDs) 14154 ankyrin repeats 14156 5'-3' exonuclease 14156 Xeroderma pigmentosum G I-region 14156 Xeroderma pigmentosum G N-region 14156 Helix-hairpin-helix class 2 (Pol1 family) motifs 14156 5'-3' exonuclease 14156 Xeroderma pigmentosum G I-region 14156 Xeroderma pigmentosum G N-region 14156 Helix-hairpin-helix class 2 (Pol1 family) motifs 14158 Tyrosine kinase, catalytic domain 14159 Tyrosine kinase, catalytic domain 14159 erine/Threonine protein kinases, catalytic domain 14159 Serine/Threonine protein kinases, catalytic domain 14163 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 14165 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 14166 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 14167 Acidic and basic fibroblast growth factor family 14167 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 14168 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 14169 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 14170 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 14177 Acidic and basic fibroblast growth factor family 14177 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 14182 Immunoglobulin 14182 Immunoglobulin C-2 Type 14182 Tyrosine kinase, catalytic domain 14183 Immunoglobulin 14183 Immunoglobulin C-2 Type 14183 Tyrosine kinase, catalytic domain 14184 Immunoglobulin 14184 Immunoglobulin C-2 Type 14184 Tyrosine kinase, catalytic domain 14186 Immunoglobulin 14186 Immunoglobulin C-2 Type 14186 Tyrosine kinase, catalytic domain 14186 Immunoglobulin 14186 Immunoglobulin C-2 Type 14186 Tyrosine kinase, catalytic domain 14186 erine/Threonine protein kinases, catalytic domain 14186 Serine/Threonine protein kinases, catalytic domain 14191 Tyrosine kinase, catalytic domain 14199 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 14200 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 14201 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 14202 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 14205 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 14208 Serine/threonine phosphatases, family 2C, catalytic domain 14218 Src homology 3 domains 14218 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 14219 von Willebrand factor (vWF) type C domain 14219 C-terminal cystine knot-like domain (CTCK) 14219 Insulin growth factor-binding protein homologues 14233 FORKHEAD 14235 FORKHEAD 14236 FORKHEAD 14238 FORKHEAD 14239 FORKHEAD 14239 FORKHEAD 14241 FORKHEAD 14247 SAM / Pointed domain 14248 Gelsolin homology domain 14254 Immunoglobulin 14254 Immunoglobulin C-2 Type 14254 Tyrosine kinase, catalytic domain 14255 Tyrosine kinase, catalytic domain 14255 Tyrosine kinase, catalytic domain 14255 erine/Threonine protein kinases, catalytic domain 14257 Immunoglobulin 14257 Immunoglobulin C-2 Type 14257 Tyrosine kinase, catalytic domain 14260 Formin Homology 2 Domain 14265 K homology RNA-binding domain 14268 Fibronectin type 1 domain 14268 Fibronectin type 2 domain 14268 Fibronectin type 3 domain 14270 Src homology 3 domains 14270 Fes/CIP4 homology domain 14270 GTPase-activator protein for Rho-like GTPases 14281 basic region leucin zipper 14283 basic region leucin zipper 14302 Src homology 2 domains 14302 Src homology 3 domains 14302 Tyrosine kinase, catalytic domain 14308 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 14311 Domains present in proteins implicated in post-mortem DNA fragmentation 14312 bromo domain 14313 Kazal type serine protease inhibitors 14314 Kazal type serine protease inhibitors 14339 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 14360 Tyrosine kinase, catalytic domain 14362 Frizzled 14365 Frizzled 14366 Frizzled 14367 Frizzled 14367 Frizzled 14368 Frizzled 14369 Frizzled 14370 Frizzled 14371 Frizzled 14375 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 14377 Acid phosphatase homologues 14378 Acid phosphatase homologues 14387 P or trefoil or TFF domain 14388 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 14389 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 14390 SAM / Pointed domain 14419 Galanin 14423 Ricin-type beta-trefoil 14425 Ricin-type beta-trefoil 14426 Ricin-type beta-trefoil 14453 Calponin homology domain 14456 Laminin G domain 14456 Calcium-binding EGF-like domain 14456 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 14457 Fes/CIP4 homology domain 14457 Fes/CIP4 homology domain 14457 Domain with 2 conserved Trp (W) residues 14460 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 14462 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 14463 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 14464 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 14465 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 14473 serum albumin 14479 Domain in ubiquitin-specific proteases 14526 Glucagon like hormones 14527 Domain present in hormone receptors 14536 Ligand binding domain of hormone receptors 14536 c4 zinc finger in nuclear hormone receptors 14547 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 14559 Transforming growth factor-beta (TGF-beta) family 14560 Transforming growth factor-beta (TGF-beta) family 14562 Transforming growth factor-beta (TGF-beta) family 14563 Transforming growth factor-beta (TGF-beta) family 14566 Transforming growth factor-beta (TGF-beta) family 14579 Ras subfamily of RAS small GTPases 14602 Domain present in hormone receptors 14652 Domain present in hormone receptors 14667 Repeats found in several Drosophila proteins 14679 ARF-like small GTPases 14679 G protein alpha subunit 14679 Sar1p-like members of the Ras-family of small GTPases 14680 ARF-like small GTPases 14680 G protein alpha subunit 14680 Sar1p-like members of the Ras-family of small GTPases 14693 WD40 repeats 14693 WD40 repeats 14699 G protein gamma subunit-like motifs 14699 G protein gamma subunit-like motifs 14700 G protein gamma subunit-like motifs 14701 G protein gamma subunit-like motifs 14702 G protein gamma subunit-like motifs 14704 G protein gamma subunit-like motifs 14706 G protein gamma subunit-like motifs 14708 G protein gamma subunit-like motifs 14709 G protein gamma subunit-like motifs 14710 G protein gamma subunit-like motifs 14723 Leucine rich repeat C-terminal domain 14725 Low-density lipoprotein-receptor YWTD domain 14725 Low-density lipoprotein receptor domain class A 14756 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 14766 G-protein-coupled receptor proteolytic site domain 14772 Serine/Threonine protein kinases, catalytic domain 14773 Serine/Threonine protein kinases, catalytic domain 14783 Src homology 2 domains 14783 Ras association (RalGDS/AF-6) domain 14783 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 14784 Src homology 2 domains 14784 Src homology 3 domains 14784 Src homology 3 domains 14784 Src homology 2 domains 14786 Src homology 2 domains 14786 Ras association (RalGDS/AF-6) domain 14786 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 14786 Src homology 2 domains 14786 Ras association (RalGDS/AF-6) domain 14786 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 14787 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 14789 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 14794 Domain in SPla and the RYanodine Receptor. 14799 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14800 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14802 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14803 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14804 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14805 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14806 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14807 Bacterial periplasmic substrate-binding proteins 14807 Eukaryotic homologues of bacterial periplasmic substrate binding proteins 14807 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14809 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14809 Bacterial periplasmic substrate-binding proteins 14809 Eukaryotic homologues of bacterial periplasmic substrate binding proteins 14809 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14810 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14811 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14812 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14813 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14814 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 14824 Granulin 14897 Domain Homologous to E6-AP Carboxyl Terminus with 14912 Homeodomain 14917 Tyrosine kinase, catalytic domain 14917 Adenylyl- / guanylyl cyclase, catalytic domain 14917 erine/Threonine protein kinases, catalytic domain 14917 Serine/Threonine protein kinases, catalytic domain 14919 Adenylyl- / guanylyl cyclase, catalytic domain 14923 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 14924 Guanylate kinase homologues 14924 Domain with 2 conserved Trp (W) residues 14924 Domain present in PSD-95, Dlg, and ZO-1/2 14924 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 14924 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 14938 Trypsin-like serine protease 14939 Trypsin-like serine protease 14940 Trypsin-like serine protease 14941 Trypsin-like serine protease 14942 Trypsin-like serine protease 14943 Trypsin-like serine protease 14944 Trypsin-like serine protease 14945 Trypsin-like serine protease 14958 Domain in histone families 1 and 5 14960 Immunoglobulin C-Type 14961 Immunoglobulin C-Type 14962 Trypsin-like serine protease 14962 Domain abundant in complement control proteins 14962 Trypsin-like serine protease 14962 von Willebrand factor (vWF) type A domain 14962 Domain abundant in complement control proteins 14962 Trypsin-like serine protease 14962 von Willebrand factor (vWF) type A domain 14962 Domain abundant in complement control proteins 14963 Immunoglobulin C-Type 14964 Immunoglobulin C-Type 14964 Immunoglobulin C-Type 14964 Immunoglobulin C-Type 14968 Immunoglobulin C-Type 14968 Immunoglobulin C-Type 14968 Immunoglobulin C-Type 14969 Immunoglobulin C-Type 14969 Immunoglobulin C-Type 14969 Immunoglobulin C-Type 14972 Immunoglobulin C-Type 14972 Immunoglobulin C-Type 14985 Immunoglobulin C-Type 14985 Immunoglobulin C-Type 14991 Immunoglobulin C-Type 14997 Immunoglobulin C-Type 14997 Immunoglobulin C-Type 14997 Immunoglobulin C-Type 14998 Immunoglobulin C-Type 14999 Immunoglobulin C-Type 15000 Immunoglobulin C-Type 15001 Immunoglobulin C-Type 15001 Immunoglobulin C-Type 15001 Immunoglobulin C-Type 15002 Immunoglobulin C-Type 15006 Immunoglobulin C-Type 15006 Immunoglobulin C-Type 15007 Immunoglobulin C-Type 15007 Immunoglobulin C-Type 15013 Immunoglobulin C-Type 15016 Immunoglobulin C-Type 15018 Immunoglobulin C-Type 15039 Immunoglobulin C-Type 15040 Immunoglobulin C-Type 15042 Immunoglobulin C-Type 15043 Immunoglobulin C-Type 15051 Immunoglobulin C-Type 15064 Immunoglobulin C-Type 15077 Histone H3 15078 Histone H3 15081 Histone H3 15110 helix loop helix domain 15162 Tyrosine kinase, catalytic domain 15163 Src homology 3 domains 15170 Protein tyrosine phosphatase, catalytic domain 15170 Src homology 2 domains 15170 Dual specificity phosphatase, catalytic domain 15170 Protein tyrosine phosphatase, catalytic domain 15170 Protein tyrosine phosphatase, catalytic domain motif 15170 Src homology 2 domains 15170 Dual specificity phosphatase, catalytic domain 15170 Protein tyrosine phosphatase, catalytic domain 15170 Protein tyrosine phosphatase, catalytic domain motif 15204 Domain Homologous to E6-AP Carboxyl Terminus with 15205 Orange domain 15206 Orange domain 15207 helix loop helix domain 15208 Orange domain 15213 Orange domain 15214 Orange domain 15216 Immunoglobulin C-Type 15218 FORKHEAD 15220 FORKHEAD 15223 FORKHEAD 15227 FORKHEAD 15234 Kringle domain 15234 Trypsin-like serine protease 15234 divergent subfamily of APPLE domains 15235 Kringle domain 15235 Trypsin-like serine protease 15239 Protein present in Fab1, YOTB, Vac1, and EEA1 15251 PAS domain 15257 Serine/Threonine protein kinases, catalytic domain 15257 Tyrosine kinase, catalytic domain 15257 erine/Threonine protein kinases, catalytic domain 15257 Serine/Threonine protein kinases, catalytic domain 15258 Serine/Threonine protein kinases, catalytic domain 15259 Serine/Threonine protein kinases, catalytic domain 15260 WD40 repeats 15267 Histone 2A 15269 Histone H3 15270 Histone 2A 15289 high mobility group 15372 Homeodomain 15373 Homeodomain 15373 Homeodomain 15379 Homeodomain 15381 RNA recognition motif 15382 RNA recognition motif 15384 RNA recognition motif 15387 K homology RNA-binding domain 15388 RNA recognition motif 15416 Homeodomain 15421 Homeodomain 15422 Homeodomain 15425 Homeodomain 15429 Homeodomain 15437 Homeodomain 15439 Trypsin-like serine protease 15441 Domain in histone families 1 and 5 15441 Domain in histone families 1 and 5 15451 Scavenger receptor Cys-rich 15451 Trypsin-like serine protease 15458 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 15461 Ras subfamily of RAS small GTPases 15463 Putative GTP-ase activating proteins for the small GTPase, ARF 15463 Putative GTP-ase activating proteins for the small GTPase, ARF 15467 Serine/Threonine protein kinases, catalytic domain 15467 Tyrosine kinase, catalytic domain 15467 Serine/Threonine protein kinases, catalytic domain 15468 Src homology 3 domains 15499 heat shock factor 15519 Histidine kinase-like ATPases 15530 Immunoglobulin 15530 Laminin B domain 15530 Laminin G domain 15530 Immunoglobulin C-2 Type 15530 Laminin-type epidermal growth factor-like domai 15530 Low-density lipoprotein receptor domain class A 15547 RNA recognition motif 15547 Ribosomal RNA adenine dimethylases 15547 RNA recognition motif 15568 RNA recognition motif 15569 RNA recognition motif 15571 RNA recognition motif 15572 RNA recognition motif 15874 calcitonin 15894 Immunoglobulin 15898 Immunoglobulin 15901 helix loop helix domain 15903 helix loop helix domain 15904 helix loop helix domain 15962 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15965 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15967 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15968 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15969 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15970 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15974 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15977 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 15980 Fibronectin type 3 domain 15985 Immunoglobulin 16000 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 16001 Furin-like repeats 16001 Fibronectin type 3 domain 16001 Tyrosine kinase, catalytic domain 16001 erine/Threonine protein kinases, catalytic domain 16001 Serine/Threonine protein kinases, catalytic domain 16002 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 16004 Fibronectin type 2 domain 16005 Leucine rich repeat C-terminal domain 16005 Leucine rich repeat N-terminal domain 16005 Leucine rich repeat C-terminal domain 16005 Leucine rich repeat N-terminal domain 16006 Insulin growth factor-binding protein homologues 16007 von Willebrand factor (vWF) type C domain 16007 Insulin growth factor-binding protein homologues 16008 Insulin growth factor-binding protein homologues 16009 Insulin growth factor-binding protein homologues 16010 Insulin growth factor-binding protein homologues 16011 Insulin growth factor-binding protein homologues 16012 Insulin growth factor-binding protein homologues 16061 Immunoglobulin 16061 Immunoglobulin V-Type 16065 Immunoglobulin 16065 Immunoglobulin V-Type 16098 Immunoglobulin 16098 Immunoglobulin V-Type 16114 Immunoglobulin 16114 Immunoglobulin C-Type 16114 Immunoglobulin V-Type 16117 Immunoglobulin 16117 Immunoglobulin V-Type 16149 Thyroglobulin type I repeats 16149 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 16150 Serine/Threonine protein kinases, catalytic domain 16150 Tyrosine kinase, catalytic domain 16150 erine/Threonine protein kinases, catalytic domain 16150 Serine/Threonine protein kinases, catalytic domain 16153 Interleukin-10 family 16157 Immunoglobulin 16158 Immunoglobulin 16160 Immunoglobulin C-2 Type 16163 Interleukins 4 and 13 16169 Domain abundant in complement control proteins 16170 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 16175 Interleukin-1 homologues 16176 Interleukin-1 homologues 16177 Immunoglobulin 16177 Immunoglobulin C-2 Type 16178 Immunoglobulin 16180 Immunoglobulin 16180 Immunoglobulin 16181 Interleukin-1 homologues 16182 Immunoglobulin 16183 Interleukin-2 family 16183 Interleukin-2 family 16183 Interleukin-2 family 16185 Fibronectin type 3 domain 16186 Fibronectin type 3 domain 16193 Interleukin-6 homologues 16194 Immunoglobulin C-2 Type 16194 Fibronectin type 3 domain 16194 Immunoglobulin 16194 Immunoglobulin C-2 Type 16194 Fibronectin type 3 domain 16195 Fibronectin type 3 domain 16196 Interleukin-7 and interleukin-9 family. IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its functio 16201 Double-stranded RNA binding motif 16201 domain in DSRM or ZnF_C2H2 domain containing proteins 16206 Immunoglobulin 16206 Leucine rich repeat C-terminal domain 16210 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 16323 Transforming growth factor-beta (TGF-beta) family 16325 Transforming growth factor-beta (TGF-beta) family 16326 Transforming growth factor-beta (TGF-beta) family 16330 Inositol polyphosphate phosphatase, catalytic domain homologues 16330 GTPase-activator protein for Rho-like GTPases 16331 Src homology 2 domains 16331 Inositol polyphosphate phosphatase, catalytic domain homologues 16332 Src homology 2 domains 16332 Inositol polyphosphate phosphatase, catalytic domain homologues 16337 Tyrosine kinase, catalytic domain 16341 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 16348 ankyrin repeats 16351 Kelch domain 16364 Domain B in dwarfin family proteins 16367 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 16369 Phosphotyrosine-binding domain (IRS1-like) 16369 Phosphotyrosine-binding domain (IRS1-like) 16370 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 16371 Homeodomain 16372 Homeodomain 16373 Homeodomain 16392 Homeodomain 16396 Domain with 2 conserved Trp (W) residues 16396 Protein kinase C conserved region 2 (CalB) 16396 Domain Homologous to E6-AP Carboxyl Terminus with 16398 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16399 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16399 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16400 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16401 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16402 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16403 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16403 Integrin alpha (beta-propellor repeats) 16403 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 16404 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16407 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16407 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16408 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16408 Integrin alpha (beta-propellor repeats) 16408 von Willebrand factor (vWF) type A domain 16408 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 16409 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16410 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16410 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16411 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 16412 von Willebrand factor (vWF) type A domain 16412 Integrin beta subunits (N-terminal portion of extracellular region) 16413 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 16418 translation initiation factor 6 16418 translation initiation factor 6 16424 Vault protein Inter-alpha-Trypsin domain 16424 von Willebrand factor (vWF) type A domain 16425 Vault protein Inter-alpha-Trypsin domain 16425 von Willebrand factor (vWF) type A domain 16426 Vault protein Inter-alpha-Trypsin domain 16426 von Willebrand factor (vWF) type A domain 16427 Vault protein Inter-alpha-Trypsin domain 16427 von Willebrand factor (vWF) type A domain 16428 Tyrosine kinase, catalytic domain 16428 Bruton's tyrosine kinase Cys-rich motif 16428 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 16429 Fibrinogen-related domains (FReDs) 16433 Zona pellucida (ZP) domain 16433 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 16438 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 16443 Eps15 homology domain 16443 Src homology 3 domains 16443 Protein kinase C conserved region 2 (CalB) 16443 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 16449 von Willebrand factor (vWF) type C domain 16450 von Willebrand factor (vWF) type C domain 16451 Band 4.1 homologues 16451 Src homology 2 domains 16451 Tyrosine kinase, catalytic domain 16452 Band 4.1 homologues 16452 Src homology 2 domains 16452 Tyrosine kinase, catalytic domain 16453 Band 4.1 homologues 16453 Src homology 2 domains 16453 Tyrosine kinase, catalytic domain 16453 Band 4.1 homologues 16453 Src homology 2 domains 16456 Immunoglobulin 16469 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 16470 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 16475 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 16480 Armadillo/beta-catenin-like repeats 16511 Cyclic nucleotide-monophosphate binding domain 16512 Cyclic nucleotide-monophosphate binding domain 16542 Immunoglobulin 16542 Immunoglobulin C-2 Type 16542 Tyrosine kinase, catalytic domain 16545 Leucine rich repeat N-terminal domain 16549 K homology RNA-binding domain 16552 Kinesin motor, catalytic domain. ATPase 16552 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16553 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16561 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16561 Kinesin motor, catalytic domain. ATPase 16561 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16561 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 16562 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16563 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16565 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16568 Kinesin motor, catalytic domain. ATPase 16568 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16571 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16578 Kinesin motor, catalytic domain. ATPase 16578 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16580 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16581 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16582 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 16588 U1-like zinc finger 16589 RNA recognition motif 16590 Immunoglobulin 16590 Tyrosine kinase, catalytic domain 16590 Immunoglobulin 16590 Immunoglobulin C-2 Type 16590 Tyrosine kinase, catalytic domain 16590 erine/Threonine protein kinases, catalytic domain 16590 Serine/Threonine protein kinases, catalytic domain 16612 Trypsin-like serine protease 16613 Trypsin-like serine protease 16615 Trypsin-like serine protease 16616 Trypsin-like serine protease 16617 Trypsin-like serine protease 16618 Trypsin-like serine protease 16619 Trypsin-like serine protease 16621 APPLE domain 16621 Trypsin-like serine protease 16622 Trypsin-like serine protease 16623 Trypsin-like serine protease 16624 Trypsin-like serine protease 16627 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16628 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16630 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16631 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16633 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16634 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16635 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16636 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16637 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16638 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16639 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16640 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16641 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16642 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16643 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 16644 Cystatin-like domain 16653 Ras subfamily of RAS small GTPases 16706 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 16728 Immunoglobulin 16728 Immunoglobulin C-2 Type 16768 Immunoglobulin 16769 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 16772 Laminin G domain 16772 Laminin-type epidermal growth factor-like domai 16773 Laminin B domain 16773 Laminin G domain 16773 Laminin-type epidermal growth factor-like domai 16773 BAR domain 16773 Laminin B domain 16773 Laminin N-terminal domain (domain VI) 16773 Laminin-type epidermal growth factor-like domai 16773 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 16774 Laminin B domain 16774 Laminin N-terminal domain (domain VI) 16774 Laminin-type epidermal growth factor-like domai 16775 Laminin G domain 16775 Thrombospondin N-terminal -like domains 16775 Laminin-type epidermal growth factor-like domai 16776 Laminin G domain 16776 Laminin B domain 16776 Laminin N-terminal domain (domain VI) 16776 Laminin-type epidermal growth factor-like domai 16780 Laminin N-terminal domain (domain VI) 16780 Laminin N-terminal domain (domain VI) 16780 Laminin-type epidermal growth factor-like domai 16782 Laminin B domain 16782 Laminin-type epidermal growth factor-like domai 16796 Src homology 3 domains 16796 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 16798 Tyrosine kinase, catalytic domain 16798 Extension to Ser/Thr-type protein kinases 16798 erine/Threonine protein kinases, catalytic domain 16798 Serine/Threonine protein kinases, catalytic domain 16800 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 16800 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 16801 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 16818 Src homology 2 domains 16818 Src homology 3 domains 16818 Tyrosine kinase, catalytic domain 16818 erine/Threonine protein kinases, catalytic domain 16818 Serine/Threonine protein kinases, catalytic domain 16822 Src homology 2 domains 16835 Calcium-binding EGF-like domain 16847 Fibronectin type 3 domain 16847 Fibronectin type 3 domain 16854 Galectin 16855 Galectin 16857 Galectin 16858 Galectin 16859 Galectin 16866 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 16875 Homeodomain 16875 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 16875 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 16878 leukemia inhibitory factor 16886 Tyrosine kinase, catalytic domain 16886 Tyrosine kinase, catalytic domain 16886 Domain present in PSD-95, Dlg, and ZO-1/2 16886 erine/Threonine protein kinases, catalytic domain 16886 Serine/Threonine protein kinases, catalytic domain 16886 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 16886 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 16886 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 16904 Trypsin-like serine protease 16923 Src homology 2 domains 16923 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 16924 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 16950 Scavenger receptor Cys-rich 16956 Lipoxygenase homology 2 (beta barrel) domain 16963 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 16971 Low-density lipoprotein-receptor YWTD domain 16971 Low-density lipoprotein receptor domain class A 16973 Low-density lipoprotein-receptor YWTD domain 16973 Low-density lipoprotein receptor domain class A 16974 Low-density lipoprotein-receptor YWTD domain 16974 Low-density lipoprotein receptor domain class A 16975 Low-density lipoprotein receptor domain class A 16979 Immunoglobulin 16980 Immunoglobulin 16980 Immunoglobulin C-2 Type 16980 Fibronectin type 3 domain 16981 Immunoglobulin 16981 Immunoglobulin C-2 Type 16981 Fibronectin type 3 domain 16981 Leucine rich repeat C-terminal domain 16981 Leucine rich repeat N-terminal domain 16997 Calcium-binding EGF-like domain 16998 Calcium-binding EGF-like domain 17002 Transferrin 17005 Tyrosine kinase, catalytic domain 17059 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17060 Src homology 2 domains 17064 Calcium-binding EGF-like domain 17064 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17067 Ly-6 antigen / uPA receptor -like domain 17071 Ly-6 antigen / uPA receptor -like domain 17076 Ricin-type beta-trefoil 17076 Fibronectin type 2 domain 17076 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17076 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17079 Leucine rich repeat C-terminal domain 17082 Immunoglobulin C-2 Type 17095 helix loop helix domain 17105 Alpha-lactalbumin / lysozyme C 17110 Alpha-lactalbumin / lysozyme C 17121 helix loop helix domain 17122 helix loop helix domain 17130 Domain A in dwarfin family proteins 17130 Domain B in dwarfin family proteins 17136 Immunoglobulin 17136 Immunoglobulin C-2 Type 17152 Serine/Threonine protein kinases, catalytic domain 17164 Tyrosine kinase, catalytic domain 17164 erine/Threonine protein kinases, catalytic domain 17164 Serine/Threonine protein kinases, catalytic domain 17165 Serine/Threonine protein kinases, catalytic domain 17167 Scavenger receptor Cys-rich 17169 Serine/Threonine protein kinases, catalytic domain 17169 Serine/Threonine protein kinases, catalytic domain 17172 helix loop helix domain 17173 helix loop helix domain 17174 Trypsin-like serine protease 17174 Domain abundant in complement control proteins 17174 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 17174 Trypsin-like serine protease 17174 Calcium-binding EGF-like domain 17174 Domain abundant in complement control proteins 17174 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 17174 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 17175 Calcium-binding EGF-like domain 17175 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 17179 Src homology 2 domains 17179 Src homology 3 domains 17179 Tyrosine kinase, catalytic domain 17180 Epidermal growth factor-like domain 17181 von Willebrand factor (vWF) type A domain 17184 U1-like zinc finger 17184 RNA recognition motif 17191 Methyl-CpG binding domain 17207 Spectrin repeats 17207 Src homology 3 domains 17207 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 17207 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 17207 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 17215 minichromosome maintenance proteins 17216 minichromosome maintenance proteins 17217 minichromosome maintenance proteins 17218 minichromosome maintenance proteins 17221 Domain abundant in complement control proteins 17224 Trypsin-like serine protease 17225 Trypsin-like serine protease 17227 Trypsin-like serine protease 17228 Trypsin-like serine protease 17229 Trypsin-like serine protease 17230 Trypsin-like serine protease 17231 Trypsin-like serine protease 17232 Trypsin-like serine protease 17232 Trypsin-like serine protease 17233 Trypsin-like serine protease 17251 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 17254 Alpha-amylase domain 17257 Methyl-CpG binding domain 17268 Homeodomain 17279 Serine/Threonine protein kinases, catalytic domain 17281 Protein present in Fab1, YOTB, Vac1, and EEA1 17281 Protein present in Fab1, YOTB, Vac1, and EEA1 17285 Homeodomain 17286 Homeodomain 17289 Immunoglobulin 17289 Tyrosine kinase, catalytic domain 17292 helix loop helix domain 17295 Tyrosine kinase, catalytic domain 17313 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 17318 Ring finger 17318 B-Box-type zinc finger 17318 B-Box C-terminal domain 17318 Fibronectin type 3 domain 17318 associated with SPRY domains 17318 Domain in SPla and the RYanodine Receptor. 17329 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 17329 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 17346 Serine/Threonine protein kinases, catalytic domain 17347 Serine/Threonine protein kinases, catalytic domain 17381 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17384 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17385 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17386 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17386 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17390 Fibronectin type 2 domain 17390 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17392 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17394 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 17395 Fibronectin type 2 domain 17395 Zinc-dependent metalloprotease 17441 Immunoglobulin V-Type 17441 Immunoglobulin 17441 Immunoglobulin V-Type 17444 Src homology 2 domains 17444 Src homology 3 domains 17444 Src homology 3 domains 17470 Immunoglobulin V-Type 17474 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17475 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 17524 Src homology 3 domains 17524 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 17528 Immunoglobulin V-Type 17532 Ras subfamily of RAS small GTPases 17533 Ricin-type beta-trefoil 17533 Fibronectin type 2 domain 17533 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17534 Ricin-type beta-trefoil 17534 Fibronectin type 2 domain 17534 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 17536 Homeodomain 17537 Homeodomain 17681 helix loop helix domain 17687 ATPase domain of DNA mismatch repair MUTS family 17687 DNA-binding domain of DNA mismatch repair MUTS family 17687 ATPase domain of DNA mismatch repair MUTS family 17687 DNA-binding domain of DNA mismatch repair MUTS family 17691 Serine/Threonine protein kinases, catalytic domain 17700 Transforming growth factor-beta (TGF-beta) family 17749 RNA polymerase subunit CX 17749 RNA polymerase subunit CX 17765 PHD zinc finger 17772 Protein tyrosine phosphatase, catalytic domain motif 17776 Serine/Threonine protein kinases, catalytic domain 17776 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 17831 von Willebrand factor (vWF) type D domain 17831 C-terminal cystine knot-like domain (CTCK) 17831 C-terminal cystine knot-like domain (CTCK) 17832 Ring finger 17832 B-Box-type zinc finger 17832 Domain found in sea urchin sperm protein, enterokinase, agrin 17833 C-terminal cystine knot-like domain (CTCK) 17858 Dynamin GTPase effector domain 17864 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 17868 Immunoglobulin 17868 Fibronectin type 3 domain 17870 helix loop helix domain 17876 RNA recognition motif 17877 helix loop helix domain 17880 Myosin. Large ATPases 17880 Myosin. Large ATPases. ATPase 17904 EF-hand, calcium binding motif 17909 Band 4.1 homologues 17909 Myosin. Large ATPases. ATPase 17909 Domain in Myosin and Kinesin Tails 17909 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 17909 Band 4.1 homologues 17909 Myosin. Large ATPases 17909 Myosin. Large ATPases. ATPase 17909 Domain in Myosin and Kinesin Tails 17909 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 17910 Band 4.1 homologues 17910 Src homology 3 domains 17910 Myosin. Large ATPases. ATPase 17910 Domain in Myosin and Kinesin Tails 17912 Myosin. Large ATPases. ATPase 17913 Myosin. Large ATPases. ATPase 17916 Src homology 3 domains 17916 Myosin. Large ATPases. ATPase 17920 Myosin. Large ATPases. ATPase 17921 Band 4.1 homologues 17921 Myosin. Large ATPases. ATPase 17921 Domain in Myosin and Kinesin Tails 17922 Band 4.1 homologues 17922 Src homology 3 domains 17922 Myosin. Large ATPases. ATPase 17922 Domain in Myosin and Kinesin Tails 17922 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 17925 Myosin. Large ATPases. ATPase 17925 GTPase-activator protein for Rho-like GTPases 17925 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 17926 Olfactomedin-like domains 17929 Immunoglobulin 17929 Fibronectin type 3 domain 17930 Immunoglobulin 17930 Fibronectin type 3 domain 17931 ankyrin repeats 17940 Baculoviral inhibition of apoptosis protein repeat 17948 Baculoviral inhibition of apoptosis protein repeat 17951 Baculoviral inhibition of apoptosis protein repeat 17952 Baculoviral inhibition of apoptosis protein repeat 17952 Baculoviral inhibition of apoptosis protein repeat 17966 PB1 domain 17966 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 17967 Immunoglobulin 17967 Immunoglobulin C-2 Type 17968 Immunoglobulin 17968 Immunoglobulin C-2 Type 17968 Fibronectin type 3 domain 17969 Src homology 3 domains 17969 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 17970 PB1 domain 17970 Src homology 3 domains 17970 Tetratricopeptide repeats 17972 PB1 domain 17972 Src homology 3 domains 17972 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 17973 Src homology 3 domains 17974 Src homology 2 domains 17974 Src homology 3 domains 17975 RNA recognition motif 17977 PAS domain 17977 helix loop helix domain 17978 PAS domain 17978 helix loop helix domain 17978 PAS domain 17978 helix loop helix domain 17979 PAS domain 17979 helix loop helix domain 17986 C-terminal cystine knot-like domain (CTCK) 17996 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 17999 Protein kinase C conserved region 2 (CalB) 18001 DnaJ molecular chaperone homology domain 18003 Src homology 3 domains 18004 Serine/Threonine protein kinases, catalytic domain 18005 Serine/Threonine protein kinases, catalytic domain 18007 Immunoglobulin 18007 Fibronectin type 3 domain 18011 domain in neuralized proteins 18012 helix loop helix domain 18018 ig-like, plexins, transcription factors 18019 ig-like, plexins, transcription factors 18020 Ubiquitin homologues 18020 Ubiquitin homologues 18021 ig-like, plexins, transcription factors 18022 basic region leucin zipper 18022 basic region leucin zipper 18023 basic region leucin zipper 18024 basic region leucin zipper 18025 basic region leucin zipper 18027 Domain A in dwarfin family proteins 18030 basic region leucin zipper 18033 ig-like, plexins, transcription factors 18033 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 18034 ig-like, plexins, transcription factors 18034 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 18044 CCAAT-Binding transcription Factor 18048 Trypsin-like serine protease 18050 Trypsin-like serine protease 18053 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 18071 helix loop helix domain 18073 G2 nidogen domain and fibulin 18073 Calcium-binding EGF-like domain 18073 Low-density lipoprotein-receptor YWTD domain 18073 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 18073 Thyroglobulin type I repeats 18073 G2 nidogen domain and fibulin 18073 Calcium-binding EGF-like domain 18073 Epidermal growth factor-like domain 18073 Low-density lipoprotein-receptor YWTD domain 18073 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 18073 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 18074 G2 nidogen domain and fibulin 18074 Calcium-binding EGF-like domain 18074 Low-density lipoprotein-receptor YWTD domain 18074 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 18089 Homeodomain 18092 Homeodomain 18099 Serine/Threonine protein kinases, catalytic domain 18102 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 18109 helix loop helix domain 18119 Transforming growth factor-beta (TGF-beta) family 18128 Calcium-binding EGF-like domain 18128 Domain found in Notch and Lin-12 18130 Calcium-binding EGF-like domain 18131 Calcium-binding EGF-like domain 18131 Domain found in Notch and Lin-12 18132 Domain found in Notch and Lin-12 18133 von Willebrand factor (vWF) type C domain 18133 C-terminal cystine knot-like domain (CTCK) 18133 Insulin growth factor-binding protein homologues 18139 U1-like zinc finger 18139 RNA recognition motif 18140 Ring finger 18142 PAS domain 18142 helix loop helix domain 18143 PAS domain 18143 helix loop helix domain 18143 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 18160 Adenylyl- / guanylyl cyclase, catalytic domain 18163 Armadillo/beta-catenin-like repeats 18164 Pentraxin / C-reactive protein / pentaxin family 18171 Ligand binding domain of hormone receptors 18171 c4 zinc finger in nuclear hormone receptors 18175 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 18175 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 18176 Ras subfamily of RAS small GTPases 18187 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 18187 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 18187 Coagulation factor 5/8 C-terminal domain, discoidin domain 18187 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 18187 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 18187 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 18189 Laminin G domain 18189 putative band 4.1 homologues' binding motif 18189 putative band 4.1 homologues' binding motif 18189 Laminin G domain 18189 Calcium-binding EGF-like domain 18191 Laminin G domain 18193 PHD zinc finger 18193 domain with conserved PWWP motif 18198 Immunoglobulin 18198 Immunoglobulin C-2 Type 18198 Tyrosine kinase, catalytic domain 18201 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 18208 Netrin C-terminal Domain 18208 Laminin N-terminal domain (domain VI) 18209 Laminin N-terminal domain (domain VI) 18209 Laminin-type epidermal growth factor-like domai 18211 Immunoglobulin 18211 Tyrosine kinase, catalytic domain 18211 Serine/Threonine protein kinases, catalytic domain 18212 Immunoglobulin 18212 Leucine rich repeat C-terminal domain 18213 Immunoglobulin 18213 Immunoglobulin C-2 Type 18213 Tyrosine kinase, catalytic domain 18213 Leucine rich repeat C-terminal domain 18213 Immunoglobulin 18213 Immunoglobulin C-2 Type 18213 Leucine rich repeat C-terminal domain 18214 Tyrosine kinase, catalytic domain 18218 Rhodanese Homology Domain 18256 Phospholipase A2 18315 krueppel associated box 18377 Leucine rich repeat N-terminal domain 18383 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 18392 Bromo adjacent homology domain 18412 PB1 domain 18412 Ubiquitin associated domain 18412 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 18413 leukemia inhibitory factor 18414 Fibronectin type 3 domain 18419 von Willebrand factor (vWF) type D domain 18419 C-terminal cystine knot-like domain (CTCK) 18419 von Willebrand factor (vWF) type C domain 18419 von Willebrand factor (vWF) type D domain 18451 Prolyl 4-hydroxylase alpha subunit homologues 18451 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 18452 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 18459 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 18472 Lissencephaly type-1-like homology motif 18479 Serine/Threonine protein kinases, catalytic domain 18481 Serine/Threonine protein kinases, catalytic domain 18488 Immunoglobulin 18488 Immunoglobulin 18488 Immunoglobulin C-2 Type 18488 Fibronectin type 3 domain 18491 Zinc-dependent metalloprotease 18491 LamG-like jellyroll fold domain 18491 Domain found in Notch and Lin-12 18491 Domain abundant in complement control proteins 18506 Homeodomain 18506 Paired Box domain 18509 Homeodomain 18509 Paired Box domain 18519 bromo domain 18521 K homology RNA-binding domain 18526 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 18530 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 18542 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 18545 LGN motif, putative GEFs specific for G-alpha GTPases 18552 Furin-like repeats 18553 Furin-like repeats 18555 Serine/Threonine protein kinases, catalytic domain 18557 Serine/Threonine protein kinases, catalytic domain 18559 in StAR and phosphatidylcholine transfer protein 18566 Immunoglobulin 18576 Metal dependent phosphohydrolases with conserved 'HD' motif 18576 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 18587 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 18595 Immunoglobulin 18595 Immunoglobulin C-2 Type 18595 Tyrosine kinase, catalytic domain 18595 Immunoglobulin 18595 Immunoglobulin C-2 Type 18595 Tyrosine kinase, catalytic domain 18595 erine/Threonine protein kinases, catalytic domain 18595 Serine/Threonine protein kinases, catalytic domain 18596 Immunoglobulin 18596 Tyrosine kinase, catalytic domain 18605 DNA/RNA non-specific endonuclease 18606 DNA/RNA non-specific endonuclease 18607 Serine/Threonine protein kinases, catalytic domain 18613 Immunoglobulin 18613 Immunoglobulin C-2 Type 18626 PAS domain 18627 PAS domain 18628 PAS domain 18630 WD40 repeats 18636 Thrombospondin type 1 repeats 18643 Profilin 18645 Profilin 18647 Serine/Threonine protein kinases, catalytic domain 18654 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 18676 DNA Topoisomerase IV 18682 Serine/Threonine protein kinases, catalytic domain 18693 BAR domain 18693 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 18703 Immunoglobulin 18703 Immunoglobulin V-Type 18704 Protein kinase C conserved region 2 (CalB) 18704 Phosphoinositide 3-kinase, catalytic domain 18704 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 18705 Protein kinase C conserved region 2 (CalB) 18705 Phosphoinositide 3-kinase, catalytic domain 18705 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 18706 PI3-kinase family, Ras-binding domain 18706 PI3-kinase family, p85-binding domain 18706 Phosphoinositide 3-kinase, catalytic domain 18707 PI3-kinase family, p85-binding domain 18707 Phosphoinositide 3-kinase, catalytic domain 18708 Src homology 2 domains 18708 Src homology 2 domains 18708 Src homology 3 domains 18708 GTPase-activator protein for Rho-like GTPases 18709 Src homology 2 domains 18709 Src homology 2 domains 18709 GTPase-activator protein for Rho-like GTPases 18710 Src homology 2 domains 18710 Src homology 2 domains 18711 Phosphatidylinositol phosphate kinases 18711 Protein present in Fab1, YOTB, Vac1, and EEA1 18711 Domain found in Dishevelled, Egl-10, and Pleckstrin 18715 Serine/Threonine protein kinases, catalytic domain 18715 Serine/Threonine protein kinases, catalytic domain 18715 Serine/Threonine protein kinases, catalytic domain 18717 Phosphatidylinositol phosphate kinases 18720 Phosphatidylinositol phosphate kinases 18736 Found in Pit-Oct-Unc transcription factors 18747 Serine/Threonine protein kinases, catalytic domain 18749 Serine/Threonine protein kinases, catalytic domain 18750 Serine/Threonine protein kinases, catalytic domain 18751 Serine/Threonine protein kinases, catalytic domain 18752 Protein kinase C conserved region 2 (CalB) 18752 Serine/Threonine protein kinases, catalytic domain 18753 Serine/Threonine protein kinases, catalytic domain 18754 Protein kinase C conserved region 2 (CalB) 18754 Serine/Threonine protein kinases, catalytic domain 18755 Protein kinase C conserved region 2 (CalB) 18755 Serine/Threonine protein kinases, catalytic domain 18759 PB1 domain 18759 Serine/Threonine protein kinases, catalytic domain 18760 Serine/Threonine protein kinases, catalytic domain 18760 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 18761 Serine/Threonine protein kinases, catalytic domain 18761 Serine/Threonine protein kinases, catalytic domain 18762 PB1 domain 18762 Serine/Threonine protein kinases, catalytic domain 18763 G-protein-coupled receptor proteolytic site domain 18763 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 18763 present in yeast cell wall integrity and stress response component proteins 18771 Homeodomain 18772 Armadillo/beta-catenin-like repeats 18779 Ricin-type beta-trefoil 18779 Fibronectin type 2 domain 18779 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 18781 Phospholipase A2 18783 Cytoplasmic phospholipase A2, catalytic subunit 18784 Phospholipase A2 18788 SERine Proteinase INhibitors 18791 Fibronectin type 1 domain 18791 Trypsin-like serine protease 18792 Trypsin-like serine protease 18793 Ly-6 antigen / uPA receptor -like domain 18797 Protein kinase C conserved region 2 (CalB) 18798 Phospholipase C, catalytic domain (part) 18798 Protein kinase C conserved region 2 (CalB) 18798 Phospholipase C, catalytic domain (part) 18798 Protein kinase C conserved region 2 (CalB) 18799 Phospholipase C, catalytic domain (part) 18799 Protein kinase C conserved region 2 (CalB) 18799 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 18802 Phospholipase C, catalytic domain (part) 18802 Phospholipase C, catalytic domain (part) 18802 Protein kinase C conserved region 2 (CalB) 18803 Src homology 2 domains 18803 Src homology 3 domains 18803 Phospholipase C, catalytic domain (part) 18803 Protein kinase C conserved region 2 (CalB) 18803 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 18805 Phospholipase D. Active site motifs 18805 PhoX homologous domain, present in p47phox and p40phox 18805 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 18805 Phospholipase D. Active site motifs. Phosphatidylcholine-hydrolyzing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of cert 18805 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 18810 Plectin repeat 18815 Kringle domain 18815 Trypsin-like serine protease 18815 divergent subfamily of APPLE domains 18816 SERine Proteinase INhibitors 18817 Serine/Threonine protein kinases, catalytic domain 18822 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 18829 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 18830 BPI/LBP/CETP N-terminal domain 18844 semaphorin domain 18844 ig-like, plexins, transcription factors 18844 domain found in Plexins, Semaphorins and Integrins 18845 semaphorin domain 18845 ig-like, plexins, transcription factors 18845 GTPase-activator protein for Ras-like GTPases 18845 domain found in Plexins, Semaphorins and Integrins 18846 semaphorin domain 18846 ig-like, plexins, transcription factors 18846 GTPase-activator protein for Ras-like GTPases 18846 domain found in Plexins, Semaphorins and Integrins 18947 Lipoxygenase homology 2 (beta barrel) domain 18970 DNA polymerase X family 18986 Found in Pit-Oct-Unc transcription factors 18987 Found in Pit-Oct-Unc transcription factors 18988 Found in Pit-Oct-Unc transcription factors 18991 Found in Pit-Oct-Unc transcription factors 18992 Found in Pit-Oct-Unc transcription factors 18993 Found in Pit-Oct-Unc transcription factors 18994 Found in Pit-Oct-Unc transcription factors 18996 Homeodomain 18996 Found in Pit-Oct-Unc transcription factors 19009 Found in Pit-Oct-Unc transcription factors 19015 Ligand binding domain of hormone receptors 19015 c4 zinc finger in nuclear hormone receptors 19017 RNA recognition motif 19018 leucine rich region 19023 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19024 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 19039 Scavenger receptor Cys-rich 19042 Serine/threonine phosphatases, family 2C, catalytic domain 19043 Serine/threonine phosphatases, family 2C, catalytic domain 19045 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19046 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19047 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19047 Protein phosphatase 2A homologues, catalytic domain 19047 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19050 Putative single-stranded nucleic acids-binding domain 19052 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19053 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19055 Protein phosphatase 2A homologues, catalytic domain 19055 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19056 Protein phosphatase 2A homologues, catalytic domain 19056 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19057 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19059 Eps15 homology domain 19060 Tetratricopeptide repeats 19060 Protein phosphatase 2A homologues, catalytic domain 19060 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 19062 Inositol polyphosphate phosphatase, catalytic domain homologues 19062 Inositol polyphosphate phosphatase, catalytic domain homologues 19074 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 19082 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 19084 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 19084 Cyclic nucleotide-monophosphate binding domain 19084 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 19085 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 19087 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 19088 Cyclic nucleotide-monophosphate binding domain 19088 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 19091 Cyclic nucleotide-monophosphate binding domain 19091 Serine/Threonine protein kinases, catalytic domain 19092 Serine/Threonine protein kinases, catalytic domain 19094 Serine/Threonine protein kinases, catalytic domain 19099 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 19106 Double-stranded RNA binding motif 19106 Serine/Threonine protein kinases, catalytic domain 19108 Serine/Threonine protein kinases, catalytic domain 19116 Fibronectin type 3 domain 19122 Major prion protein 19123 Trypsin-like serine protease 19123 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 19128 Calcium-binding EGF-like domain 19128 Domain containing Gla (gamma-carboxyglutamate) residues 19128 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 19134 Serine/Threonine protein kinases, catalytic domain 19142 Kringle domain 19142 Scavenger receptor Cys-rich 19142 Trypsin-like serine protease 19143 Trypsin-like serine protease 19143 Low-density lipoprotein receptor domain class A 19143 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 19144 Trypsin-like serine protease 19146 Trypsin-like serine protease 19146 Low-density lipoprotein receptor domain class A 19146 Low-density lipoprotein receptor domain class A 19152 Trypsin-like serine protease 19153 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 19156 Saposins-like type B 19156 Saposin/surfactant protein-B A-type DOMAIN 19157 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 19158 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 19159 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 19181 ATPases associated with a variety of cellular activities 19200 Src homology 3 domains 19200 Fes/CIP4 homology domain 19200 Src homology 3 domains 19200 Fes/CIP4 homology domain 19205 RNA recognition motif 19221 Immunoglobulin 19221 Immunoglobulin V-Type 19226 Parathyroid hormone 19228 Domain present in hormone receptors 19229 Band 4.1 homologues 19229 Tyrosine kinase, catalytic domain 19229 Tyrosine kinase, catalytic domain 19229 erine/Threonine protein kinases, catalytic domain 19229 Serine/Threonine protein kinases, catalytic domain 19230 Actin depolymerisation factor/cofilin -like domains 19243 Dual specificity phosphatase, catalytic domain 19243 Protein tyrosine phosphatase, catalytic domain 19243 Protein tyrosine phosphatase, catalytic domain motif 19246 Protein tyrosine phosphatase, catalytic domain 19247 Protein tyrosine phosphatase, catalytic domain 19248 Protein tyrosine phosphatase, catalytic domain 19249 Band 4.1 homologues 19249 Protein tyrosine phosphatase, catalytic domain 19249 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 19250 Band 4.1 homologues 19250 Protein tyrosine phosphatase, catalytic domain 19252 Rhodanese Homology Domain 19253 Protein tyrosine phosphatase, catalytic domain 19255 Protein tyrosine phosphatase, catalytic domain 19256 Protein tyrosine phosphatase, catalytic domain 19258 Protein tyrosine phosphatase, catalytic domain 19259 Protein tyrosine phosphatase, catalytic domain 19260 Protein tyrosine phosphatase, catalytic domain 19261 Immunoglobulin 19261 Immunoglobulin C-Type 19261 Immunoglobulin 19261 Immunoglobulin V-Type 19261 Immunoglobulin C-Type 19262 Protein tyrosine phosphatase, catalytic domain 19263 Protein tyrosine phosphatase, catalytic domain 19264 Protein tyrosine phosphatase, catalytic domain 19266 Immunoglobulin 19266 Immunoglobulin C-2 Type 19266 Fibronectin type 3 domain 19266 Dual specificity phosphatase, catalytic domain 19266 Protein tyrosine phosphatase, catalytic domain 19266 Protein tyrosine phosphatase, catalytic domain motif 19267 Protein tyrosine phosphatase, catalytic domain 19268 Immunoglobulin 19268 Immunoglobulin C-2 Type 19268 Fibronectin type 3 domain 19268 Protein tyrosine phosphatase, catalytic domain 19270 Fibronectin type 3 domain 19270 Protein tyrosine phosphatase, catalytic domain 19271 Fibronectin type 3 domain 19271 Protein tyrosine phosphatase, catalytic domain 19272 Immunoglobulin 19272 Fibronectin type 3 domain 19272 Protein tyrosine phosphatase, catalytic domain 19272 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 19273 Immunoglobulin 19273 Fibronectin type 3 domain 19273 Protein tyrosine phosphatase, catalytic domain 19273 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 19274 Immunoglobulin 19274 Fibronectin type 3 domain 19274 Protein tyrosine phosphatase, catalytic domain 19274 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 19275 Protein tyrosine phosphatase, catalytic domain 19277 Protein tyrosine phosphatase, catalytic domain 19279 Protein tyrosine phosphatase, catalytic domain 19280 Immunoglobulin 19280 Immunoglobulin C-2 Type 19280 Fibronectin type 3 domain 19280 Protein tyrosine phosphatase, catalytic domain 19281 Fibronectin type 3 domain 19281 Protein tyrosine phosphatase, catalytic domain 19281 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 19283 Dual specificity phosphatase, catalytic domain 19283 Protein tyrosine phosphatase, catalytic domain 19283 Protein tyrosine phosphatase, catalytic domain motif 19288 Pentraxin / C-reactive protein / pentaxin family 19289 Immunoglobulin 19289 Immunoglobulin C-2 Type 19290 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 19291 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 19294 Immunoglobulin V-Type 19317 K homology RNA-binding domain 19326 Rab subfamily of small GTPases 19328 Rab subfamily of small GTPases 19328 Ras subfamily of RAS small GTPases 19328 Rho (Ras homology) subfamily of Ras-like small GTPases 19330 Rab subfamily of small GTPases 19330 Rab subfamily of small GTPases 19331 ARF-like small GTPases 19331 Rab subfamily of small GTPases 19331 Ras subfamily of RAS small GTPases 19331 Rho (Ras homology) subfamily of Ras-like small GTPases 19331 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 19332 ARF-like small GTPases 19332 Rab subfamily of small GTPases 19332 Ras subfamily of RAS small GTPases 19332 Rho (Ras homology) subfamily of Ras-like small GTPases 19332 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 19337 Rab subfamily of small GTPases 19338 Rab subfamily of small GTPases 19339 Rab subfamily of small GTPases 19340 Rab subfamily of small GTPases 19341 Rab subfamily of small GTPases 19342 Rab subfamily of small GTPases 19345 ARF-like small GTPases 19345 Rab subfamily of small GTPases 19345 Ras subfamily of RAS small GTPases 19345 Rho (Ras homology) subfamily of Ras-like small GTPases 19345 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 19346 Rab subfamily of small GTPases 19347 domain involved in Ras-like GTPase signaling 19348 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 19349 Rab subfamily of small GTPases 19353 Rab subfamily of small GTPases 19353 Ras subfamily of RAS small GTPases 19353 Rho (Ras homology) subfamily of Ras-like small GTPases 19353 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 19354 Rho (Ras homology) subfamily of Ras-like small GTPases 19358 Ubiquitin associated domain 19359 Ubiquitin associated domain 19376 Rab subfamily of small GTPases 19383 RNA recognition motif 19384 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 19385 Ran-binding domain 19385 Ran-binding domain 19395 Guanine nucleotide exchange factor for Ras-like GTPases 19395 Guanine nucleotide exchange factor for Ras-like small GTPases 19414 Bruton's tyrosine kinase Cys-rich motif 19414 Protein kinase C conserved region 2 (CalB) 19414 GTPase-activator protein for Ras-like GTPases 19414 Bruton's tyrosine kinase Cys-rich motif 19414 Protein kinase C conserved region 2 (CalB) 19414 GTPase-activator protein for Ras-like GTPases 19414 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 19415 Bruton's tyrosine kinase Cys-rich motif 19415 GTPase-activator protein for Ras-like GTPases 19416 Ras subfamily of RAS small GTPases 19417 Guanine nucleotide exchange factor for Ras-like GTPases 19417 Guanine nucleotide exchange factor for Ras-like small GTPases 19417 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 19418 Guanine nucleotide exchange factor for Ras-like GTPases 19418 Guanine nucleotide exchange factor for Ras-like small GTPases 19419 Guanine nucleotide exchange factor for Ras-like GTPases 19419 Guanine nucleotide exchange factor for Ras-like small GTPases 19428 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 19647 Ring finger 19649 Immunoglobulin 19649 Immunoglobulin C-2 Type 19649 Fibronectin type 3 domain 19650 domain present in cyclins, TFIIB and Retinoblastoma 19652 RNA recognition motif 19653 RNA recognition motif 19654 RNA recognition motif 19655 RNA recognition motif 19656 RNA recognition motif 19657 RNA recognition motif 19663 RNA recognition motif 19663 RNA recognition motif 19692 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 19693 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 19695 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 19696 ig-like, plexins, transcription factors 19697 ig-like, plexins, transcription factors 19698 ig-like, plexins, transcription factors 19700 Ras subfamily of RAS small GTPases 19707 Eps15 homology domain 19712 zinc finger 19713 Tyrosine kinase, catalytic domain 19714 DNA polymerase type-B family 19715 krueppel associated box 19718 ATPases associated with a variety of cellular activities 19720 Ring finger 19720 associated with SPRY domains 19730 Guanine nucleotide exchange factor for Ras-like GTPases 19730 Guanine nucleotide exchange factor for Ras-like small GTPases 19731 Guanine nucleotide exchange factor for Ras-like GTPases 19731 Guanine nucleotide exchange factor for Ras-like small GTPases 19732 Guanine nucleotide exchange factor for Ras-like GTPases 19732 Guanine nucleotide exchange factor for Ras-like small GTPases 19734 Regulator of G protein signalling domain 19737 Regulator of G protein signalling domain 19739 G protein gamma subunit-like motifs 19739 Regulator of G protein signalling domain 19739 Domain found in Dishevelled, Egl-10, and Pleckstrin 19744 Ras subfamily of RAS small GTPases 19752 Pancreatic ribonuclease 19762 Ras subfamily of RAS small GTPases 19763 Ring finger 19763 Ring finger 19765 GTPase-activator protein for Rho-like GTPases 19765 GTPase-activator protein for Rho-like GTPases 19766 Tyrosine kinase, catalytic domain 19769 Ras subfamily of RAS small GTPases 19773 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 19824 associated with SPRY domains 19824 Domain in SPla and the RYanodine Receptor. 19826 RNA recognition motif 19876 Immunoglobulin 19876 Fibronectin type 3 domain 19876 Fibronectin type 3 domain 19877 Extension to Ser/Thr-type protein kinases 19877 Serine/Threonine protein kinases, catalytic domain 19877 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 19878 Serine/Threonine protein kinases, catalytic domain 19878 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 19882 Tyrosine kinase, catalytic domain 19882 ig-like, plexins, transcription factors 19886 Fibronectin type 3 domain 19886 Tyrosine kinase, catalytic domain 19886 erine/Threonine protein kinases, catalytic domain 19886 Serine/Threonine protein kinases, catalytic domain 19888 Domain in the Doublecortin (DCX) gene product 19888 Domain in the Doublecortin (DCX) gene product 19889 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 19889 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 20016 RNA polymerases D 20021 RNA polymerases D 20111 Serine/Threonine protein kinases, catalytic domain 20112 Serine/Threonine protein kinases, catalytic domain 20130 Ras subfamily of RAS small GTPases 20166 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 20166 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 20182 c4 zinc finger in nuclear hormone receptors 20185 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 20187 Tyrosine kinase, catalytic domain 20187 Wnt-inhibitory factor-1 like domain 20187 erine/Threonine protein kinases, catalytic domain 20187 Serine/Threonine protein kinases, catalytic domain 20191 Domain in SPla and the RYanodine Receptor. 20191 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 20195 EF-hand, calcium binding motif 20209 Serum amyloid A proteins 20211 Serum amyloid A proteins 20222 U1-like zinc finger 20224 Sar1p-like members of the Ras-family of small GTPases 20230 Homeodomain 20238 domain in Ataxins and HMG containing proteins 20256 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 20259 Gelsolin homology domain 20274 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 20290 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20292 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20293 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20295 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20297 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20298 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20299 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20300 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20301 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20304 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20304 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC) 20304 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20304 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC) 20304 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20307 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20308 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20312 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 20317 SERine Proteinase INhibitors 20319 Frizzled 20319 Netrin C-terminal Domain 20320 Immunoglobulin 20321 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the t 20321 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at presen 20338 Sel1-like repeats 20338 Fibronectin type 2 domain 20338 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 20339 Domain abundant in complement control proteins 20343 Domain abundant in complement control proteins 20343 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 20344 Domain abundant in complement control proteins 20346 domain found in Plexins, Semaphorins and Integrins 20346 semaphorin domain 20346 domain found in Plexins, Semaphorins and Integrins 20347 domain found in Plexins, Semaphorins and Integrins 20347 semaphorin domain 20347 domain found in Plexins, Semaphorins and Integrins 20348 Immunoglobulin 20348 domain found in Plexins, Semaphorins and Integrins 20349 domain found in Plexins, Semaphorins and Integrins 20350 Immunoglobulin 20350 domain found in Plexins, Semaphorins and Integrins 20351 domain found in Plexins, Semaphorins and Integrins 20352 semaphorin domain 20352 domain found in Plexins, Semaphorins and Integrins 20353 Immunoglobulin 20353 semaphorin domain 20353 domain found in Plexins, Semaphorins and Integrins 20354 Immunoglobulin 20354 domain found in Plexins, Semaphorins and Integrins 20355 semaphorin domain 20355 domain found in Plexins, Semaphorins and Integrins 20355 semaphorin domain 20355 domain found in Plexins, Semaphorins and Integrins 20355 semaphorin domain 20355 domain found in Plexins, Semaphorins and Integrins 20356 Thrombospondin type 1 repeats 20356 semaphorin domain 20356 Thrombospondin type 1 repeats 20356 domain found in Plexins, Semaphorins and Integrins 20357 Thrombospondin type 1 repeats 20358 semaphorin domain 20358 domain found in Plexins, Semaphorins and Integrins 20359 semaphorin domain 20360 semaphorin domain 20361 semaphorin domain 20370 Domain abundant in complement control proteins 20370 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 20371 FORKHEAD 20377 Frizzled 20377 Netrin C-terminal Domain 20378 Frizzled 20379 Frizzled 20382 RNA recognition motif 20383 RNA recognition motif 20384 RNA recognition motif 20388 Saposin/surfactant protein-B A-type DOMAIN 20389 Pulmonary surfactant proteins 20393 Serine/Threonine protein kinases, catalytic domain 20399 Src homology 2 domains 20399 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 20400 Src homology 2 domains 20401 BAR domain 20403 Eps15 homology domain 20403 Src homology 3 domains 20404 BAR domain 20404 Src homology 3 domains 20405 BAR domain 20405 Src homology 3 domains 20408 BAR domain 20408 Src homology 3 domains 20409 Src homology 3 domains 20410 Src homology 3 domains 20410 Sorbin homologous domain 20411 Src homology 3 domains 20418 Src homology 2 domains 20420 Src homology 2 domains 20431 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 20459 Src homology 2 domains 20459 Src homology 3 domains 20459 Tyrosine kinase, catalytic domain 20462 RNA recognition motif 20464 PAS domain 20464 helix loop helix domain 20464 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 20465 PAS domain 20465 helix loop helix domain 20465 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 20465 PAS domain 20465 helix loop helix domain 20465 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 20471 Homeodomain 20472 Homeodomain 20473 Homeodomain 20474 Homeodomain 20476 Homeodomain 20491 Src homology 2 domains 20491 Src homology 3 domains 20532 Alpha-amylase domain 20532 Alpha-amylase domain 20541 Domains in Na-Ca exchangers and integrin-beta4 20563 Laminin G domain 20563 Laminin G domain 20563 Calcium-binding EGF-like domain 20563 Leucine rich repeat N-terminal domain 20563 Leucine rich repeat C-terminal domain 20563 Leucine-rich repeats, typical (most populated) subfamily 20564 Laminin G domain 20564 Leucine rich repeat C-terminal domain 20564 C-terminal cystine knot-like domain (CTCK) 20564 Leucine-rich repeats, typical (most populated) subfamily 20568 Four-disulfide core domains 20586 bromo domain 20586 DEAD-like helicases superfamily 20586 helicase superfamily c-terminal domain 20586 domain in transcription and CHROMO domain helicases 20586 domain in helicases and associated with SANT domains 20589 AN1-like Zinc finger 20589 Putative single-stranded nucleic acids-binding domain 20592 PHD zinc finger 20595 Tudor domain 20596 Frizzled 20602 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 20612 Immunoglobulin 20612 Immunoglobulin C-2 Type 20614 Helical region found in SNAREs 20614 Helical region found in SNAREs 20619 Helical region found in SNAREs 20620 Serine/Threonine protein kinases, catalytic domain 20623 Serine/Threonine protein kinases, catalytic domain 20623 Tyrosine kinase, catalytic domain 20623 erine/Threonine protein kinases, catalytic domain 20623 Serine/Threonine protein kinases, catalytic domain 20638 snRNP Sm proteins 20638 snRNP Sm proteins 20639 RNA recognition motif 20643 snRNP Sm proteins 20643 snRNP Sm proteins 20646 snRNP Sm proteins 20648 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 20649 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 20650 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 20650 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 20660 Fibronectin type 3 domain 20661 VPS10 domain 20662 Histone 2A 20662 Guanine nucleotide exchange factor for Ras-like GTPases 20662 Guanine nucleotide exchange factor for Ras-like small GTPases 20662 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 20662 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 20663 Guanine nucleotide exchange factor for Ras-like small GTPases 20665 high mobility group 20668 high mobility group 20669 high mobility group 20672 high mobility group 20677 high mobility group 20681 high mobility group 20686 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 20687 zinc finger 20689 zinc finger 20689 zinc finger 20692 Follistatin-N-terminal domain-like 20706 SERine Proteinase INhibitors 20707 SERine Proteinase INhibitors 20708 SERine Proteinase INhibitors 20709 SERine Proteinase INhibitors 20710 SERine Proteinase INhibitors 20713 SERine Proteinase INhibitors 20715 SERine Proteinase INhibitors 20719 SERine Proteinase INhibitors 20723 SERine Proteinase INhibitors 20725 SERine Proteinase INhibitors 20726 SERine Proteinase INhibitors 20728 erythroblast transformation specific domain 20731 Kazal type serine protease inhibitors 20732 Low-density lipoprotein receptor domain class A 20732 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 20733 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 20733 BPTI/Kunitz family of serine protease inhibitors 20733 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 20739 Spectrin repeats 20740 Spectrin repeats 20740 EF-hand, calcium binding motif 20740 Spectrin repeats 20740 EF-hand, calcium binding motif 20741 Spectrin repeats 20742 Spectrin repeats 20742 Spectrin repeats 20742 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 20743 Spectrin repeats 20743 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 20744 Double-stranded RNA binding motif 20744 domain in DSRM or ZnF_C2H2 domain containing proteins 20745 Kazal type serine protease inhibitors 20779 Tyrosine kinase, catalytic domain 20788 helix loop helix domain 20811 Src homology 2 domains 20811 Tyrosine kinase, catalytic domain 20815 Serine/Threonine protein kinases, catalytic domain 20817 Serine/Threonine protein kinases, catalytic domain 20821 associated with SPRY domains 20823 Domain in the RNA-binding Lupus La protein 20833 high mobility group 20840 Src homology 3 domains 20844 Src homology 3 domains 20845 in StAR and phosphatidylcholine transfer protein 20849 Src homology 2 domains 20853 Double-stranded RNA binding motif 20862 Cystatin-like domain 20866 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 20868 Serine/Threonine protein kinases, catalytic domain 20869 Serine/Threonine protein kinases, catalytic domain 20871 Serine/Threonine protein kinases, catalytic domain 20873 Serine/Threonine protein kinases, catalytic domain 20873 Serine/Threonine protein kinases, catalytic domain 20874 Serine/Threonine protein kinases, catalytic domain 20877 Tyrosine kinase, catalytic domain 20877 erine/Threonine protein kinases, catalytic domain 20877 Serine/Threonine protein kinases, catalytic domain 20878 Tyrosine kinase, catalytic domain 20878 erine/Threonine protein kinases, catalytic domain 20878 Serine/Threonine protein kinases, catalytic domain 20890 found in Wnt-1 20893 Orange domain 20913 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 20926 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 20926 Src homology 2 domains 20926 Ribosomal protein S1-like RNA-binding domain 20926 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 20926 Src homology 2 domains 20926 Ribosomal protein S1-like RNA-binding domain 20926 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 20927 ATPases associated with a variety of cellular activities 20937 Chromatin organization modifier domain 20957 DNA Topoisomerase I (eukaryota) 20963 Src homology 2 domains 20963 Tyrosine kinase, catalytic domain 20980 Protein kinase C conserved region 2 (CalB) 20983 Protein kinase C conserved region 2 (CalB) 21332 Immunoglobulin 21346 Calponin homology domain 21350 helix loop helix domain 21356 Immunoglobulin C-Type 21356 Immunoglobulin C-Type 21356 Immunoglobulin C-Type 21357 Double-stranded RNA binding motif 21367 Fibronectin type 3 domain 21372 Lissencephaly type-1-like homology motif 21372 WD40 repeats 21372 Lissencephaly type-1-like homology motif 21375 Domain first found in the mice T locus (Brachyury) protein 21376 "FY-rich" domain, C-terminal region 21376 "FY-rich" domain, N-terminal region 21380 Domain first found in the mice T locus (Brachyury) protein 21383 Domain first found in the mice T locus (Brachyury) protein 21384 Domain first found in the mice T locus (Brachyury) protein 21385 Domain first found in the mice T locus (Brachyury) protein 21386 Domain first found in the mice T locus (Brachyury) protein 21386 Domain first found in the mice T locus (Brachyury) protein 21387 Domain first found in the mice T locus (Brachyury) protein 21388 Domain first found in the mice T locus (Brachyury) protein 21389 Domain first found in the mice T locus (Brachyury) protein 21399 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 21399 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 21400 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 21400 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 21401 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 21401 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 21401 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 21405 Homeodomain 21407 helix loop helix domain 21408 krueppel associated box 21410 Homeodomain 21412 helix loop helix domain 21413 helix loop helix domain 21417 Homeodomain 21423 helix loop helix domain 21429 high mobility group 21429 high mobility group 21453 Lissencephaly type-1-like homology motif 21673 DNA polymerase X family 21679 TEA domain 21681 RNA recognition motif 21682 Src homology 2 domains 21682 Tyrosine kinase, catalytic domain 21683 von Willebrand factor (vWF) type D domain 21683 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 21684 Zona pellucida (ZP) domain 21685 basic region leucin zipper 21685 basic region leucin zipper 21687 Immunoglobulin 21687 Fibronectin type 3 domain 21687 Tyrosine kinase, catalytic domain 21687 Laminin-type epidermal growth factor-like domai 21744 Double-stranded RNA binding motif 21744 Double-stranded RNA binding motif 21744 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 21749 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 21750 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 21753 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 21754 Tyrosine kinase, catalytic domain 21755 Trypsin-like serine protease 21756 Trypsin-like serine protease 21761 Chromatin organization modifier domain 21785 P or trefoil or TFF domain 21787 PB1 domain 21788 BPTI/Kunitz family of serine protease inhibitors 21788 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 21789 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 21810 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 21812 GS motif 21815 Homeodomain 21815 Homeodomain 21819 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 21821 Tetratricopeptide repeats 21824 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 21825 Thrombospondin type 1 repeats 21825 Thrombospondin type 1 repeats 21825 Calcium-binding EGF-like domain 21826 Thrombospondin type 1 repeats 21826 Calcium-binding EGF-like domain 21826 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 21827 Calcium-binding EGF-like domain 21827 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 21828 Calcium-binding EGF-like domain 21833 Ligand binding domain of hormone receptors 21833 c4 zinc finger in nuclear hormone receptors 21838 Immunoglobulin V-Type 21844 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 21844 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 21844 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 21846 Immunoglobulin 21846 Tyrosine kinase, catalytic domain 21846 Laminin-type epidermal growth factor-like domai 21848 bromo domain 21848 PHD zinc finger 21848 B-Box C-terminal domain 21849 bromo domain 21849 B-Box C-terminal domain 21859 Tissue inhibitor of metalloproteinase family. Form complexes with metalloproteinases, such as collagenases, and irreversibly inactivate them 21872 Domain present in ZO-1 and Unc5-like netrin receptors 21872 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 21872 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 21873 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 21873 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 21892 Calcium-binding EGF-like domain 21894 I/LWEQ domain 21897 Leucine rich repeat C-terminal domain 21899 Leucine rich repeat C-terminal domain 21922 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 21923 Fibronectin type 3 domain 21923 Fibrinogen-related domains (FReDs) 21926 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 21937 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 21939 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 21939 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 21939 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 21941 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 21943 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 21944 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 21945 Death effector domain 21946 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 21951 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 21960 Fibronectin type 3 domain 21960 Fibrinogen-related domains (FReDs) 21960 Fibronectin type 3 domain 21960 Fibrinogen-related domains (FReDs) 21961 Src homology 2 domains 21961 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 21968 Domain present in VPS-27, Hrs and STAM 21969 DNA Topoisomerase I (eukaryota) 21973 TopoisomeraseII 21973 DNA Topoisomerase IV 21974 TopoisomeraseII 21974 DNA Topoisomerase IV 21981 ankyrin repeats 21981 Src homology 3 domains 21981 Ras association (RalGDS/AF-6) domain 21983 Leucine rich repeat C-terminal domain 22018 Calcium-binding EGF-like domain 22024 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 22026 Ligand binding domain of hormone receptors 22030 meprin and TRAF homology 22035 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 22040 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 22041 Transferrin 22061 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 22062 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 22062 Sterile alpha motif 22062 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 22072 Trypsin-like serine protease 22072 Trypsin-like serine protease 22072 Trypsin-like serine protease 22073 Trypsin-like serine protease 22073 Trypsin-like serine protease 22074 Trypsin-like serine protease 22074 Trypsin-like serine protease 22074 Trypsin-like serine protease 22088 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 22094 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 22113 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 22114 Serine/Threonine protein kinases, catalytic domain 22114 Tyrosine kinase, catalytic domain 22114 Serine/Threonine protein kinases, catalytic domain 22114 Tyrosine kinase, catalytic domain 22114 Serine/Threonine protein kinases, catalytic domain 22115 Serine/Threonine protein kinases, catalytic domain 22123 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 22129 Ring finger 22137 Serine/Threonine protein kinases, catalytic domain 22138 Immunoglobulin 22138 Immunoglobulin 22138 Immunoglobulin C-2 Type 22165 Src homology 2 domains 22165 Tyrosine kinase, catalytic domain 22174 Immunoglobulin 22174 Tyrosine kinase, catalytic domain 22183 RRM_1 domain 22184 RRM_1 domain 22185 RNA recognition motif 22186 Ubiquitin homologues 22186 Ubiquitin homologues 22195 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 22195 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 22214 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 22215 Domain Homologous to E6-AP Carboxyl Terminus with 22215 Domain Homologous to E6-AP Carboxyl Terminus with 22241 Serine/Threonine protein kinases, catalytic domain 22242 Calcium-binding EGF-like domain 22249 Protein kinase C conserved region 2 (CalB) 22253 Immunoglobulin 22253 Thrombospondin type 1 repeats 22253 Domain present in ZO-1 and Unc5-like netrin receptors 22253 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 22258 Domain in ubiquitin-specific proteases 22283 Fibronectin type 3 domain 22283 LamG-like jellyroll fold domain 22283 Laminin N-terminal domain (domain VI) 22283 Laminin-type epidermal growth factor-like domai 22287 Uteroglobin 22287 Uteroglobin 22288 Spectrin repeats 22288 Calponin homology domain 22288 Domain with 2 conserved Trp (W) residues 22288 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 22289 A domain family that is part of the cupin metalloenzyme superfamily 22289 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 22295 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 22324 Src homology 2 domains 22324 Src homology 3 domains 22325 Src homology 2 domains 22325 Src homology 3 domains 22329 Immunoglobulin 22329 Immunoglobulin C-2 Type 22339 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 22339 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 22340 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 22341 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 22341 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 22342 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22343 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22349 Villin headpiece domain 22349 Gelsolin homology domain 22351 Gelsolin homology domain 22353 Glucagon like hormones 22354 Domain present in hormone receptors 22355 Domain present in hormone receptors 22359 Calcium-binding EGF-like domain 22359 Low-density lipoprotein receptor domain class A 22362 Immunoglobulin V-Type 22363 Immunoglobulin V-Type 22364 Immunoglobulin V-Type 22364 Immunoglobulin 22364 Immunoglobulin V-Type 22364 Immunoglobulin 22364 Immunoglobulin V-Type 22370 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 22371 von Willebrand factor (vWF) type C domain 22371 von Willebrand factor (vWF) type D domain 22371 C-terminal cystine knot-like domain (CTCK) 22371 von Willebrand factor (vWF) type D domain 22371 C-terminal cystine knot-like domain (CTCK) 22371 von Willebrand factor (vWF) type C domain 22371 von Willebrand factor (vWF) type D domain 22373 Four-disulfide core domains 22379 Formin Homology 2 Domain 22380 U1-like zinc finger 22380 Domain with 2 conserved Trp (W) residues 22384 RNA recognition motif 22385 bromo domain 22385 domain in different transcription and chromosome remodeling factors 22401 U1-like zinc finger 22402 Insulin growth factor-binding protein homologues 22403 von Willebrand factor (vWF) type C domain 22408 found in Wnt-1 22411 found in Wnt-1 22421 found in Wnt-1 22423 found in Wnt-1 22427 3'-5' exonuclease 22427 DEAD-like helicases superfamily 22427 Helicase and RNase D C-terminal 22427 helicase superfamily c-terminal domain 22433 basic region leucin zipper 22592 Xeroderma pigmentosum G N-region 22596 von Willebrand factor (vWF) type A domain 22596 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen 22601 Domain with 2 conserved Trp (W) residues 22612 Tyrosine kinase, catalytic domain 22612 Src homology 3 domains 22612 Src homology 2 domains 22612 Tyrosine kinase, catalytic domain 22612 erine/Threonine protein kinases, catalytic domain 22612 Serine/Threonine protein kinases, catalytic domain 22637 Tyrosine kinase, catalytic domain 22640 krueppel associated box 22652 Ring finger 22652 zinc finger 22668 zinc finger 22668 zinc finger 22668 K homology RNA-binding domain 22671 Ring finger 22673 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 22673 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 22673 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 22682 A20-like zinc fingers 22687 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins 22688 krueppel associated box 22689 krueppel associated box 22693 krueppel associated box 22695 zinc finger 22697 leucine rich region 22698 krueppel associated box 22709 krueppel associated box 22715 krueppel associated box 22715 krueppel associated box 22715 krueppel associated box 22717 krueppel associated box 22718 krueppel associated box 22719 krueppel associated box 22750 krueppel associated box 22751 krueppel associated box 22754 krueppel associated box 22756 krueppel associated box 22758 leucine rich region 22763 U1-like zinc finger 22763 domain in DSRM or ZnF_C2H2 domain containing proteins 22770 Homeodomain 22776 krueppel associated box 22786 P or trefoil or TFF domain 22789 Domain abundant in complement control proteins 22792 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 22793 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 22795 G2 nidogen domain and fibulin 22795 Calcium-binding EGF-like domain 22795 Low-density lipoprotein-receptor YWTD domain 22795 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 22795 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 22798 Laminin N-terminal domain (domain VI) 22798 Laminin-type epidermal growth factor-like domai 22800 Ras subfamily of RAS small GTPases 22801 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 22802 von Willebrand factor (vWF) type A domain 22808 Ras subfamily of RAS small GTPases 22809 basic region leucin zipper 22821 Protein kinase C conserved region 2 (CalB) 22821 GTPase-activator protein for Ras-like GTPases 22823 Tudor domain 22827 RRM_1 domain 22827 RRM_1 domain 22828 RNA recognition motif 22828 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 22835 krueppel associated box 22843 Serine/threonine phosphatases, family 2C, catalytic domain 22844 Band 4.1 homologues 22844 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22848 Serine/Threonine protein kinases, catalytic domain 22849 RNA recognition motif 22850 Homeodomain 22853 Tyrosine kinase, catalytic domain 22854 Laminin N-terminal domain (domain VI) 22854 Laminin-type epidermal growth factor-like domai 22858 Serine/Threonine protein kinases, catalytic domain 22858 Serine/Threonine protein kinases, catalytic domain 22858 Serine/Threonine protein kinases, catalytic domain 22859 Olfactomedin-like domains 22859 Domain present in hormone receptors 22862 Fibronectin type 3 domain 22865 Leucine rich repeat C-terminal domain 22866 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22866 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 22866 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 22869 krueppel associated box 22874 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 22877 helix loop helix domain 22882 Homeodomain 22883 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 22885 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 22887 FORKHEAD 22888 Modified RING finger domain 22894 Large family of predicted nucleotide-binding domains 22897 Domain with 2 conserved Trp (W) residues 22899 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 22904 DEAD-like helicases superfamily 22905 Epsin N-terminal homology (ENTH) domain 22905 Epsin N-terminal homology (ENTH) domain 22911 C-terminal to LisH motif. 22913 RNA recognition motif 22913 RNA recognition motif 22915 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 22916 RNA recognition motif 22918 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 22925 Ricin-type beta-trefoil 22925 Fibronectin type 2 domain 22925 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 22926 basic region leucin zipper 22931 Rab subfamily of small GTPases 22941 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22941 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 22941 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22944 U1-like zinc finger 22954 Ring finger 22954 B-Box-type zinc finger 22955 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 22976 breast cancer carboxy-terminal domain 22983 Tyrosine kinase, catalytic domain 22983 Extension to Ser/Thr-type protein kinases 22983 Serine/Threonine protein kinases, catalytic domain 22983 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 22985 RNA recognition motif 22986 VPS10 domain 22989 Myosin. Large ATPases. ATPase 22993 high mobility group 22997 Immunoglobulin 22997 Immunoglobulin C-2 Type 22997 Fibronectin type 3 domain 22998 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 22999 Protein kinase C conserved region 2 (CalB) 22999 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23001 Protein present in Fab1, YOTB, Vac1, and EEA1 23001 Protein present in Fab1, YOTB, Vac1, and EEA1 23002 Formin Homology 2 Domain 23005 WD40 repeats 23007 Phospholipase C, catalytic domain (part) 23007 Protein kinase C conserved region 2 (CalB) 23008 Kelch domain 23012 Serine/Threonine protein kinases, catalytic domain 23013 RNA recognition motif 23022 Immunoglobulin 23024 Ring finger 23024 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23025 Protein kinase C conserved region 2 (CalB) 23029 RNA recognition motif 23030 Tudor domain 23030 PHD zinc finger 23030 Small domain found in the jumonji family of transcription factors 23030 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 23031 Tyrosine kinase, catalytic domain 23031 Serine/Threonine protein kinases, catalytic domain 23031 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23032 Domain in ubiquitin-specific proteases 23035 Serine/threonine phosphatases, family 2C, catalytic domain 23037 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23037 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23043 Tyrosine kinase, catalytic domain 23043 Serine/Threonine protein kinases, catalytic domain 23043 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 23048 Src homology 3 domains 23051 Homeodomain 23052 DNA/RNA non-specific endonuclease 23058 Phosphatidylinositol phosphate kinases 23061 EF-hand, calcium binding motif 23067 Cysteine-rich motif following a subset of SET domains 23067 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 23072 Protein kinase C conserved region 2 (CalB) 23072 Domain Homologous to E6-AP Carboxyl Terminus with 23075 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23075 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 23077 Ring finger 23077 Filamin-type immunoglobulin domains 23078 von Willebrand factor (vWF) type A domain 23081 Tudor domain 23082 RNA recognition motif 23087 Ring finger 23087 B-Box C-terminal domain 23087 associated with SPRY domains 23087 Ring finger 23092 BAR domain 23092 Src homology 3 domains 23092 GTPase-activator protein for Rho-like GTPases 23092 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23094 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23095 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 23095 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23096 Sec7 domain 23096 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 23097 Serine/Threonine protein kinases, catalytic domain 23097 Tyrosine kinase, catalytic domain 23097 Serine/Threonine protein kinases, catalytic domain 23098 Toll - interleukin 1 - resistance 23098 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 23101 Spectrin repeats 23101 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 23101 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 23101 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23102 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 23105 Immunoglobulin 23105 Immunoglobulin C-2 Type 23105 factor I membrane attack complex 23105 Kazal type serine protease inhibitors 23112 RNA recognition motif 23113 In Between Ring fingers 23114 Immunoglobulin 23114 Immunoglobulin C-2 Type 23114 Fibronectin type 3 domain 23118 Zinc finger domain 23119 Broad-Complex, Tramtrack and Bric a brac 23126 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 23126 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 23129 semaphorin domain 23129 ig-like, plexins, transcription factors 23129 domain found in Plexins, Semaphorins and Integrins 23133 PHD zinc finger 23133 PHD zinc finger 23133 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 23135 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 23139 Serine/Threonine protein kinases, catalytic domain 23139 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23143 Calponin homology domain 23145 krueppel associated box 23145 zinc finger in transposases and transcription factors 23149 Fes/CIP4 homology domain 23150 Band 4.1 homologues 23151 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 23152 high mobility group 23158 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 23158 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 23160 WD40 repeats 23161 Domain associated with PX domains 23161 Regulator of G protein signalling domain 23161 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 23164 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23166 Link (Hyaluronan-binding) 23166 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 23174 zinc finger 23178 Serine/Threonine protein kinases, catalytic domain 23179 Guanine nucleotide exchange factor for Ras-like GTPases 23179 Guanine nucleotide exchange factor for Ras-like small GTPases 23185 Domain in the RNA-binding Lupus La protein 23187 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 23190 Domain present in ubiquitin-regulatory proteins 23194 Leucine-rich repeat - CC (cysteine-containing) subfamily 23197 UAS domain 23207 domain involved in Ras-like GTPase signaling 23207 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 23208 Protein kinase C conserved region 2 (CalB) 23211 zinc finger 23216 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 23217 U1-like zinc finger 23217 domain in DSRM or ZnF_C2H2 domain containing proteins 23218 WD40 repeats 23220 Ring finger 23220 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 23221 Broad-Complex, Tramtrack and Bric a brac 23221 Rho (Ras homology) subfamily of Ras-like small GTPases 23224 Spectrin repeats 23224 Spectrin repeats 23224 Spectrin repeats 23224 Spectrin repeats 23224 Spectrin repeats 23228 Phospholipase C, catalytic domain (part) 23228 Phospholipase C, catalytic domain (part) 23228 Protein kinase C conserved region 2 (CalB) 23229 Src homology 3 domains 23229 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 23232 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 23235 Tyrosine kinase, catalytic domain 23235 Serine/Threonine protein kinases, catalytic domain 23236 Protein kinase C conserved region 2 (CalB) 23236 Protein kinase C conserved region 2 (CalB) 23239 Serine/threonine phosphatases, family 2C, catalytic domain 23239 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 23243 ankyrin repeats 23245 membrane-attack complex / perforin 23248 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 23249 Thrombospondin type 1 repeats 23258 domain involved in Ras-like GTPase signaling 23259 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 23263 Spectrin repeats 23263 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 23263 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 23266 Olfactomedin-like domains 23266 Domain present in hormone receptors 23268 BAR domain 23268 Src homology 3 domains 23268 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 23273 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 23284 Olfactomedin-like domains 23284 Domain present in hormone receptors 23286 Domain with 2 conserved Trp (W) residues 23287 Zn_pept domain 23291 A Receptor for Ubiquitination Targets 23291 A Receptor for Ubiquitination Targets 23291 A Receptor for Ubiquitination Targets 23293 Large family of predicted nucleotide-binding domains 23294 ankyrin repeats 23294 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 23294 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 23302 present in yeast cell wall integrity and stress response component proteins 23303 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 23304 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 23308 Immunoglobulin V-Type 23314 Homeodomain 23316 Homeodomain 23317 DnaJ molecular chaperone homology domain 23321 B-Box-type zinc finger 23321 B-Box C-terminal domain 23321 Filamin-type immunoglobulin domains 23322 Protein kinase C conserved region 2 (CalB) 23327 Protein kinase C conserved region 2 (CalB) 23328 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 23329 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 23339 Clathrin heavy chain repeat homology 23339 Clathrin heavy chain repeat homology 23339 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 23341 DnaJ molecular chaperone homology domain 23344 Protein kinase C conserved region 2 (CalB) 23345 Spectrin repeats 23345 Spectrin repeats 23348 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23350 RNA recognition motif 23350 Suppressor-of-White-APricot splicing regulator 23350 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 23352 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 23360 Domain with 2 conserved Trp (W) residues 23362 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23363 Immunoglobulin 23363 Immunoglobulin C-2 Type 23363 Fibronectin type 3 domain 23365 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 23365 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23367 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 23368 Src homology 3 domains 23370 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 23371 Src homology 2 domains 23371 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 23371 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 23371 Src homology 2 domains 23371 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 23371 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 23380 Src homology 3 domains 23380 GTPase-activator protein for Rho-like GTPases 23381 Large family of predicted nucleotide-binding domains 23384 Calponin homology domain 23394 Homeodomain 23394 Homeodomain 23396 Phosphatidylinositol phosphate kinases 23396 Phosphatidylinositol phosphate kinases 23405 Ribonuclease III family 23405 Ribonuclease III family 23406 Actin depolymerisation factor/cofilin -like domains 23413 EF-hand, calcium binding motif 23416 Cyclic nucleotide-monophosphate binding domain 23416 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 23418 Laminin G domain 23418 Calcium-binding EGF-like domain 23426 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23429 Zinc finger domain 23430 Trypsin-like serine protease 23433 Rho (Ras homology) subfamily of Ras-like small GTPases 23435 RNA recognition motif 23436 Trypsin-like serine protease 23452 Fibrinogen-related domains (FReDs) 23458 ATPases associated with a variety of cellular activities 23462 Orange domain 23466 Chromatin organization modifier domain 23467 Pentraxin / C-reactive protein / pentaxin family 23467 Pentraxin / C-reactive protein / pentaxin family 23469 PHD zinc finger 23469 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 23473 calpain_III domain 23473 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 23476 bromo domain 23476 bromo domain 23493 Orange domain 23499 Spectrin repeats 23499 Spectrin repeats 23500 Formin Homology 2 Domain 23500 Formin Homology 2 Domain 23503 Protein present in Fab1, YOTB, Vac1, and EEA1 23504 Src homology 3 domains 23504 Fibronectin type 3 domain 23510 Broad-Complex, Tramtrack and Bric a brac 23513 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23513 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23518 Putative single-stranded nucleic acids-binding domain 23522 Domain in histone families 1 and 5 23526 Fes/CIP4 homology domain 23526 GTPase-activator protein for Rho-like GTPases 23526 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 23527 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23536 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 23543 RNA recognition motif 23544 Domain abundant in complement control proteins 23544 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 23547 Immunoglobulin 23550 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23551 Ras subfamily of RAS small GTPases 23552 Serine/Threonine protein kinases, catalytic domain 23552 Serine/Threonine protein kinases, catalytic domain 23567 U1-like zinc finger 23581 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 23584 Immunoglobulin 23584 Immunoglobulin V-Type 23601 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 23604 Serine/Threonine protein kinases, catalytic domain 23607 Src homology 3 domains 23608 zinc finger 23612 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23613 bromo domain 23616 BAR domain 23617 Serine/Threonine protein kinases, catalytic domain 23619 krueppel associated box 23623 Src homology 3 domains 23637 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 23637 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 23639 occurring C-terminal to leucine-rich repeats 23650 B-Box-type zinc finger 23650 B-Box-type zinc finger 23654 GTPase-activator protein for Ras-like GTPases 23660 leucine rich region 23660 leucine rich region 23671 Kazal type serine protease inhibitors 23678 Serine/Threonine protein kinases, catalytic domain 23678 Serine/Threonine protein kinases, catalytic domain 23682 Rab subfamily of small GTPases 23683 Serine/Threonine protein kinases, catalytic domain 23683 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23705 Immunoglobulin 23732 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at present 23759 Modified RING finger domain 23759 Modified RING finger domain 23759 Modified RING finger domain 23762 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23769 Fibronectin type 3 domain 23770 Tetratricopeptide repeats 23774 bromo domain 23774 domain with conserved PWWP motif 23779 GTPase-activator protein for Rho-like GTPases 23779 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 23779 GTPase-activator protein for Rho-like GTPases 23779 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 23779 GTPase-activator protein for Rho-like GTPases 23792 ADAM Cysteine-Rich Domain 23792 Homologues of snake disintegrins 23792 ADAM Cysteine-Rich Domain 23792 Homologues of snake disintegrins 23793 ADAM Cysteine-Rich Domain 23793 Homologues of snake disintegrins 23794 Thrombospondin type 1 repeats 23797 Serine/Threonine protein kinases, catalytic domain 23797 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23806 In Between Ring fingers 23807 In Between Ring fingers 23808 Domain in SPla and the RYanodine Receptor. 23829 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 23830 calpain_III domain 23830 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 23836 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 23844 von Willebrand factor (vWF) type A domain 23845 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 23853 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23854 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 23856 PHD zinc finger 23859 Src homology 3 domains 23859 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 23859 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 23871 SAM / Pointed domain 23871 erythroblast transformation specific domain 23872 SAM / Pointed domain 23876 Calcium-binding EGF-like domain 23879 K homology RNA-binding domain 23880 Src homology 3 domains 23881 RNA recognition motif 23886 Transforming growth factor-beta (TGF-beta) family 23912 Rho (Ras homology) subfamily of Ras-like small GTPases 23920 Tyrosine kinase, catalytic domain 23921 Src homology 2 domains 23921 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 23938 PB1 domain 23938 Serine/Threonine protein kinases, catalytic domain 23939 Serine/Threonine protein kinases, catalytic domain 23942 Bromo adjacent homology domain 23942 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 23942 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 23943 Protein kinase C conserved region 2 (CalB) 23947 Ring finger 23947 B-Box C-terminal domain 23947 Fibronectin type 3 domain 23947 Domain in SPla and the RYanodine Receptor. 23948 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 23954 Serine/Threonine protein kinases, catalytic domain 23955 Serine/Threonine protein kinases, catalytic domain 23968 Leucine rich repeat, ribonuclease inhibitor type 23969 Src homology 3 domains 23969 Fes/CIP4 homology domain 23970 Src homology 3 domains 23983 K homology RNA-binding domain 23984 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 23992 Double-stranded RNA binding motif 23993 Trypsin-like serine protease 23997 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 23999 Actin depolymerisation factor/cofilin -like domains 24000 Band 4.1 homologues 24000 Protein tyrosine phosphatase, catalytic domain 24001 Raf-like Ras-binding domain 24001 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 24001 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 24001 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 24012 G protein gamma subunit-like motifs 24013 Serine/Threonine protein kinases, catalytic domain 24014 Serine/Threonine protein kinases, catalytic domain 24014 domain in protein kinases, N-glycanases and other nuclear proteins 24014 Tyrosine kinase, catalytic domain 24014 erine/Threonine protein kinases, catalytic domain 24014 Serine/Threonine protein kinases, catalytic domain 24014 domain in protein kinases, N-glycanases and other nuclear proteins 24018 Dual specificity phosphatase, catalytic domain 24047 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 24055 Src homology 2 domains 24055 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 24057 Src homology 3 domains 24058 Immunoglobulin 24070 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. Function unknown, but likely to be associated with the glycosylation machinery 24071 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 24086 Serine/Threonine protein kinases, catalytic domain 24086 Tyrosine kinase, catalytic domain 24086 erine/Threonine protein kinases, catalytic domain 24086 Serine/Threonine protein kinases, catalytic domain 24087 Calcium-binding EGF-like domain 24088 Leucine rich repeat C-terminal domain 24099 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 24102 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 24108 Ubiquitin homologues 24117 Wnt-inhibitory factor-1 like domain 24131 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 24135 krueppel associated box 24136 Homeodomain 24137 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 24144 glycine rich nucleic binding domain 24149 U1-like zinc finger 24161 Low molecular weight phosphatase family 24163 Trypsin-like serine protease 24167 Domain present in hormone receptors 24177 serum albumin 24185 Serine/Threonine protein kinases, catalytic domain 24186 serum albumin 24205 Armadillo/beta-catenin-like repeats 24209 helix loop helix domain 24223 Immunoglobulin C-Type 24224 BH4 Bcl-2 homology region 4 24231 Trypsin-like serine protease 24231 Domain abundant in complement control proteins 24231 Trypsin-like serine protease 24233 Netrin C-terminal Domain 24233 Anaphylatoxin homologous domain 24235 Domain abundant in complement control proteins 24236 Domain abundant in complement control proteins 24237 Thrombospondin type 1 repeats 24237 factor I membrane attack complex 24237 Low-density lipoprotein receptor domain class A 24241 calcitonin 24245 Serine/Threonine protein kinases, catalytic domain 24246 Serine/Threonine protein kinases, catalytic domain 24250 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 24252 basic region leucin zipper 24253 basic region leucin zipper 24256 Immunoglobulin 24256 Immunoglobulin C-2 Type 24277 Beta/gamma crystallins 24279 Beta/gamma crystallins 24291 Trypsin-like serine protease 24309 basic region leucin zipper 24323 Endothelin 24329 Tyrosine kinase, catalytic domain 24331 Trypsin-like serine protease 24332 Trypsin-like serine protease 24336 Fibronectin type 3 domain 24337 Tyrosine kinase, catalytic domain 24356 SAM / Pointed domain 24366 Fibrinogen-related domains (FReDs) 24373 Kazal type serine protease inhibitors 24384 serum albumin 24406 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24407 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24407 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24408 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24409 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24410 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24411 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24412 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 24446 Kringle domain 24446 Trypsin-like serine protease 24446 divergent subfamily of APPLE domains 24456 Homeodomain 24457 Homeodomain 24459 Homeodomain 24464 Trypsin-like serine protease 24476 calcitonin 24482 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 24482 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 24483 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 24484 Insulin growth factor-binding protein homologues 24493 Interleukin-1 homologues 24494 Interleukin-1 homologues 24498 Interleukin-6 homologues 24499 Immunoglobulin C-2 Type 24514 Band 4.1 homologues 24514 Src homology 2 domains 24514 Tyrosine kinase, catalytic domain 24520 Broad-Complex, Tramtrack and Bric a brac 24522 krueppel associated box 24523 Trypsin-like serine protease 24525 Ras subfamily of RAS small GTPases 24536 Fibronectin type 3 domain 24553 Tyrosine kinase, catalytic domain 24558 Immunoglobulin V-Type 24560 Immunoglobulin V-Type 24564 Immunoglobulin V-Type 24566 Kringle domain 24566 Trypsin-like serine protease 24575 Dynamin, GTPase 24581 helix loop helix domain 24586 Immunoglobulin 24586 Immunoglobulin C-2 Type 24592 GTPase-activator protein for Ras-like GTPases 24592 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 24594 Trypsin-like serine protease 24596 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 24603 Adenylyl- / guanylyl cyclase, catalytic domain 24605 Ras subfamily of RAS small GTPases 24620 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 24620 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 24629 Immunoglobulin 24629 Tyrosine kinase, catalytic domain 24653 Cytoplasmic phospholipase A2, catalytic subunit 24654 Phospholipase C, catalytic domain (part) 24654 Protein kinase C conserved region 2 (CalB) 24655 Phospholipase C, catalytic domain (part) 24655 Protein kinase C conserved region 2 (CalB) 24655 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 24663 RNA polymerase I subunit A N-terminus 24666 Serine/threonine phosphatases, family 2C, catalytic domain 24667 Serine/threonine phosphatases, family 2C, catalytic domain 24668 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 24669 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 24672 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 24673 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 24674 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 24675 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 24679 Cyclic nucleotide-monophosphate binding domain 24681 Protein kinase C conserved region 2 (CalB) 24681 Serine/Threonine protein kinases, catalytic domain 24686 Major prion protein 24686 Major prion protein 24691 Trypsin-like serine protease 24695 Parathyroid hormone 24697 Protein tyrosine phosphatase, catalytic domain 24699 Fibronectin type 3 domain 24699 Protein tyrosine phosphatase, catalytic domain 24699 Fibronectin type 3 domain 24699 Protein tyrosine phosphatase, catalytic domain 24699 Protein tyrosine phosphatase, catalytic domain motif 24711 tail specific protease 24714 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 24737 Immunoglobulin C-Type 24747 Immunoglobulin C-Type 24748 Immunoglobulin C-Type 24791 Follistatin-N-terminal domain-like 24805 Protein kinase C conserved region 2 (CalB) 24817 Homeodomain 24820 Immunoglobulin C-Type 24825 Transferrin 24826 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 24828 Histone 2A 24829 Histone H2B 24832 Immunoglobulin V-Type 24835 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 24841 Trypsin-like serine protease 24856 Transthyretin 24881 found in Wnt-1 24882 found in Wnt-1 24888 BH4 Bcl-2 homology region 4 24903 Cystatin-like domain 24916 Ring finger 24924 Pleiotrophin / midkine family 24926 Immunoglobulin 24926 Immunoglobulin C-2 Type 24930 Immunoglobulin 24931 Immunoglobulin V-Type 24932 Immunoglobulin 24933 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 24933 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 24934 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 24943 Myelin proteolipid protein (PLP or lipophilin) 24946 Trypsin-like serine protease 24948 K homology RNA-binding domain 24953 Domain present in hormone receptors 24953 Domain present in hormone receptors 24954 Tyrosine kinase, catalytic domain 25006 Ligand binding domain of hormone receptors 25006 c4 zinc finger in nuclear hormone receptors 25012 Helical region found in SNAREs 25019 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 25021 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 25022 Tyrosine kinase, catalytic domain 25022 Serine/Threonine protein kinases, catalytic domain 25023 Protein kinase C conserved region 2 (CalB) 25023 Serine/Threonine protein kinases, catalytic domain 25024 Domain present in hormone receptors 25029 Domain present in hormone receptors 25030 Cystatin-like domain 25031 Phospholipase C, catalytic domain (part) 25031 Protein kinase C conserved region 2 (CalB) 25046 Immunoglobulin 25046 Immunoglobulin V-Type 25048 APPLE domain 25048 Trypsin-like serine protease 25049 domain in Ataxins and HMG containing proteins 25050 Serine/Threonine protein kinases, catalytic domain 25051 Domain present in hormone receptors 25052 Trypsin-like serine protease 25054 Immunoglobulin 25054 Tyrosine kinase, catalytic domain 25054 Leucine rich repeat C-terminal domain 25066 Immunoglobulin 25069 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 25084 Fibronectin type 3 domain 25087 Cystatin-like domain 25096 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25109 Immunoglobulin C-Type 25110 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 25118 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 25128 Calcium-binding EGF-like domain 25130 Syntaxin N-terminal domain 25130 Syntaxin N-terminal domain 25130 Helical region found in SNAREs 25132 Myosin. Large ATPases. ATPase 25133 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 25135 RNA recognition motif 25150 Tyrosine kinase, catalytic domain 25151 Fibronectin type 2 domain 25155 Src homology 2 domains 25155 Tyrosine kinase, catalytic domain 25156 Src homology 2 domains 25156 Src homology 3 domains 25166 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 25167 Protein tyrosine phosphatase, catalytic domain 25172 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 25177 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 25192 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 25192 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 25196 Transforming growth factor-beta (TGF-beta) family 25201 Adenylyl- / guanylyl cyclase, catalytic domain 25206 Adenylyl- / guanylyl cyclase, catalytic domain 25211 Alpha-lactalbumin / lysozyme C 25217 Immunoglobulin C-Type 25231 Homeodomain 25232 Immunoglobulin 25232 Tyrosine kinase, catalytic domain 25233 Serine/Threonine protein kinases, catalytic domain 25233 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25235 Fibronectin type 3 domain 25237 GS motif 25238 Serine/Threonine protein kinases, catalytic domain 25238 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25242 PAS domain 25243 PAS domain 25246 Immunoglobulin 25252 Src homology 3 domains 25252 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 25252 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 25255 Serine/Threonine protein kinases, catalytic domain 25266 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 25268 Trypsin-like serine protease 25268 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 25272 Serine/Threonine protein kinases, catalytic domain 25273 Frizzled 25274 Rhodanese Homology Domain 25275 ATPases associated with a variety of cellular activities 25281 Zinc finger domain 25285 Insulin growth factor-binding protein homologues 25290 Lipoxygenase homology 2 (beta barrel) domain 25294 Immunoglobulin C-Type 25295 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 25296 Transforming growth factor-beta (TGF-beta) family 25301 basic region leucin zipper 25304 Calcium-binding EGF-like domain 25306 Zn_pept domain 25307 Cystatin-like domain 25311 Immunoglobulin 25311 Immunoglobulin C-2 Type 25311 Fibronectin type 3 domain 25313 Calcium-binding EGF-like domain 25313 Low-density lipoprotein-receptor YWTD domain 25320 gastrin / cholecystokinin / caerulein family 25321 Domain present in hormone receptors 25326 Band 4.1 homologues 25326 Src homology 2 domains 25326 Tyrosine kinase, catalytic domain 25329 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 25333 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 25341 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 25341 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 25344 prohibitin homologues 25346 Fibronectin type 3 domain 25346 Tyrosine kinase, catalytic domain 25349 Immunoglobulin V-Type 25353 Osteopontin 25356 Immunoglobulin 25356 Immunoglobulin C-2 Type 25358 Tissue inhibitor of metalloproteinase family. Form complexes with metalloproteinases, such as collagenases, and irreversibly inactivate them 25361 Immunoglobulin 25361 Immunoglobulin C-2 Type 25366 Tyrosine kinase, catalytic domain 25366 Serine/Threonine protein kinases, catalytic domain 25367 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 25372 Serine/Threonine protein kinases, catalytic domain 25372 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25377 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 25378 Transforming growth factor-beta (TGF-beta) family 25381 Immunoglobulin 25382 amyloid A4 25382 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 25389 basic region leucin zipper 25393 Immunoglobulin V-Type 25397 Anaphylatoxin homologous domain 25399 von Willebrand factor (vWF) type A domain 25400 Serine/Threonine protein kinases, catalytic domain 25402 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 25407 Ly-6 antigen / uPA receptor -like domain 25409 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 25410 basic region leucin zipper 25412 Fibrillar collagens C-terminal domain 25414 Src homology 3 domains 25419 Pentraxin / C-reactive protein / pentaxin family 25434 Follistatin-N-terminal domain-like 25443 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 25445 basic region leucin zipper 25447 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 25464 Immunoglobulin 25466 Immunoglobulin 25467 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25473 Laminin-type epidermal growth factor-like domai 25474 Galectin 25475 Galectin 25476 Galectin 25481 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 25482 Ras subfamily of RAS small GTPases 25484 Src homology 3 domains 25484 Myosin. Large ATPases. ATPase 25484 Src homology 3 domains 25484 Myosin. Large ATPases. ATPase 25485 Myosin. Large ATPases. ATPase 25486 Myosin. Large ATPases. ATPase 25486 GTPase-activator protein for Rho-like GTPases 25486 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 25489 Domain with 2 conserved Trp (W) residues 25489 Protein kinase C conserved region 2 (CalB) 25489 Domain Homologous to E6-AP Carboxyl Terminus with 25493 ankyrin repeats 25503 Eps15 homology domain 25513 Src homology 2 domains 25513 Src homology 3 domains 25515 Serine/Threonine protein kinases, catalytic domain 25517 Found in Pit-Oct-Unc transcription factors 25520 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 25522 PB1 domain 25522 Serine/Threonine protein kinases, catalytic domain 25523 Serine/Threonine protein kinases, catalytic domain 25528 Immunoglobulin 25528 Immunoglobulin C-Type 25529 Immunoglobulin 25529 Immunoglobulin C-2 Type 25529 Fibronectin type 3 domain 25529 Protein tyrosine phosphatase, catalytic domain 25531 Rab subfamily of small GTPases 25532 Rab subfamily of small GTPases 25537 Serine/Threonine protein kinases, catalytic domain 25537 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 25544 Domain abundant in complement control proteins 25544 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 25556 Immunoglobulin C-2 Type 25557 in StAR and phosphatidylcholine transfer protein 25562 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 25567 Fibronectin type 3 domain 25567 Fibrinogen-related domains (FReDs) 25574 high mobility group 25575 Uteroglobin 25583 Beta/gamma crystallins 25585 helix loop helix domain 25588 P or trefoil or TFF domain 25589 Immunoglobulin 25589 Immunoglobulin C-2 Type 25589 Tyrosine kinase, catalytic domain 25592 Kazal type serine protease inhibitors 25592 Kazal type serine protease inhibitors 25592 Laminin-type epidermal growth factor-like domai 25592 Domain found in sea urchin sperm protein, enterokinase, agrin 25594 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 25597 Bruton's tyrosine kinase Cys-rich motif 25597 GTPase-activator protein for Ras-like GTPases 25597 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 25600 Spectrin repeats 25600 Domain with 2 conserved Trp (W) residues 25613 Protein tyrosine phosphatase, catalytic domain 25614 Band 4.1 homologues 25614 Tyrosine kinase, catalytic domain 25616 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 25619 Trypsin-like serine protease 25622 Protein tyrosine phosphatase, catalytic domain 25625 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 25627 Trypsin-like serine protease 25633 deoxyribonuclease I 25634 Acid phosphatase homologues 25640 Homeodomain 25641 Insulin growth factor-binding protein homologues 25644 Transforming growth factor-beta (TGF-beta) family 25644 Transforming growth factor-beta (TGF-beta) family 25647 Interleukin-7 and interleukin-9 family. IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its functio 25651 Domain abundant in complement control proteins 25653 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 25654 Fibrillar collagens C-terminal domain 25660 Immunoglobulin V-Type 25661 Fibronectin type 1 domain 25661 Fibronectin type 2 domain 25662 Insulin growth factor-binding protein homologues 25663 Immunoglobulin C-2 Type 25666 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 25667 Transforming growth factor-beta (TGF-beta) family 25676 GTPase-activator protein for Ras-like GTPases 25677 Serine/Threonine protein kinases, catalytic domain 25678 Tyrosine kinase, catalytic domain 25680 Colipase 25681 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 25685 Insulin growth factor-binding protein homologues 25691 Immunoglobulin 25691 Immunoglobulin C-2 Type 25691 Fibronectin type 3 domain 25692 Fibronectin type 1 domain 25692 Trypsin-like serine protease 25695 basic region leucin zipper 25696 Calcium-binding EGF-like domain 25696 Low-density lipoprotein receptor domain class A 25697 Papain family cysteine protease 25705 Homeodomain 25705 zinc finger 25711 Tyrosine kinase, catalytic domain 25711 Adenylyl- / guanylyl cyclase, catalytic domain 25713 Integrin beta subunits (N-terminal portion of extracellular region) 25716 Protein kinase C conserved region 2 (CalB) 25718 Tyrosine kinase, catalytic domain 25724 Domains in Na-Ca exchangers and integrin-beta4 25725 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 25734 Tyrosine kinase, catalytic domain 25738 Src homology 2 domains 25738 Phospholipase C, catalytic domain (part) 25738 Protein kinase C conserved region 2 (CalB) 25738 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25744 Band 4.1 homologues 25746 Fibronectin type 3 domain 25751 Dynamin GTPase effector domain 25752 Scavenger receptor Cys-rich 25752 Scavenger receptor Cys-rich 25759 Src homology 2 domains 25759 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 25766 Contains two conserved F residues 25771 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 25778 Tyrosine kinase, catalytic domain 25778 Serine/Threonine protein kinases, catalytic domain 25780 Guanine nucleotide exchange factor for Ras-like GTPases 25780 Guanine nucleotide exchange factor for Ras-like small GTPases 25780 Guanine nucleotide exchange factor for Ras-like GTPases 25780 Guanine nucleotide exchange factor for Ras-like small GTPases 25791 Src homology 3 domains 25791 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 25799 krueppel associated box 25803 SAM / Pointed domain 25803 erythroblast transformation specific domain 25804 snRNP Sm proteins 25807 Ubiquitin associated domain 25818 Trypsin-like serine protease 25823 Trypsin-like serine protease 25827 A Receptor for Ubiquitination Targets 25831 Domain Homologous to E6-AP Carboxyl Terminus with 25831 Domain Homologous to E6-AP Carboxyl Terminus with 25833 Found in Pit-Oct-Unc transcription factors 25837 Rab subfamily of small GTPases 25851 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 25851 Dysferlin domain, C-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th 25851 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th 25851 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 25851 Dysferlin domain, C-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 25851 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 25861 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 25865 Serine/Threonine protein kinases, catalytic domain 25878 Immunoglobulin 25878 Immunoglobulin C-2 Type 25888 krueppel associated box 25890 Fibronectin type 3 domain 25891 Trypsin-like serine protease 25891 Domain abundant in complement control proteins 25891 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 25893 associated with SPRY domains 25894 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 25897 In Between Ring fingers 25903 Olfactomedin-like domains 25930 Protein tyrosine phosphatase, catalytic domain 25937 Domain with 2 conserved Trp (W) residues 25939 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 25945 Immunoglobulin 25946 U1-like zinc finger 25948 Kelch domain 25948 Broad-Complex, Tramtrack and Bric a brac 25950 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 25959 ankyrin repeats 25960 Domain present in hormone receptors 25966 Protein kinase C conserved region 2 (CalB) 25970 Src homology 2 domains 25970 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 25975 Calcium-binding EGF-like domain 25989 Tyrosine kinase, catalytic domain 25989 Serine/Threonine protein kinases, catalytic domain 25992 Fibronectin type 3 domain 25992 Calcium-binding EGF-like domain 26000 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 26005 Protein kinase C conserved region 2 (CalB) 26013 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 26013 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 26018 Immunoglobulin 26018 Leucine rich repeat C-terminal domain 26019 Middle domain of eukaryotic initiation factor 4G (eIF4G) 26019 Middle domain of eukaryotic initiation factor 4G (eIF4G) 26020 Low-density lipoprotein receptor domain class A 26020 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 26025 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 26025 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 26027 in StAR and phosphatidylcholine transfer protein 26027 in StAR and phosphatidylcholine transfer protein 26031 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26031 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26031 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26031 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26031 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26031 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26032 Link (Hyaluronan-binding) 26033 Laminin-type epidermal growth factor-like domai 26033 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 26037 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 26038 Chromatin organization modifier domain 26043 UAS domain 26043 Domain present in ubiquitin-regulatory proteins 26046 Ring finger 26047 Laminin G domain 26047 putative band 4.1 homologues' binding motif 26048 leucine rich region 26048 krueppel associated box 26050 Leucine rich repeat C-terminal domain 26056 Protein kinase C conserved region 2 (CalB) 26057 K homology RNA-binding domain 26060 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 26083 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 26084 Src homology 3 domains 26084 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 26085 Trypsin-like serine protease 26103 Immunoglobulin 26103 Leucine rich repeat C-terminal domain 26108 PHD zinc finger 26119 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 26130 Domain present in VPS9 26130 GTPase-activator protein for Ras-like GTPases 26136 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 26136 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 26147 Tudor domain 26152 krueppel associated box 26153 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 26166 Regulator of G protein signalling domain 26167 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 26191 Protein tyrosine phosphatase, catalytic domain 26191 Protein tyrosine phosphatase, catalytic domain 26223 A Receptor for Ubiquitination Targets 26228 Src homology 2 domains 26230 Raf-like Ras-binding domain 26230 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 26230 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 26234 Leucine-rich repeat - CC (cysteine-containing) subfamily 26234 Leucine-rich repeat - CC (cysteine-containing) subfamily 26235 Leucine-rich repeat - CC (cysteine-containing) subfamily 26249 Kelch domain 26249 Broad-Complex, Tramtrack and Bric a brac 26253 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 26256 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 26256 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 26256 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 26256 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 26256 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 26267 A Receptor for Ubiquitination Targets 26269 Sec7 domain 26270 A Receptor for Ubiquitination Targets 26280 Immunoglobulin 26280 Immunoglobulin C-2 Type 26290 Ricin-type beta-trefoil 26291 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 26295 Tetratricopeptide repeats 26298 SAM / Pointed domain 26298 erythroblast transformation specific domain 26298 SAM / Pointed domain 26298 erythroblast transformation specific domain 26360 Fibrinogen-related domains (FReDs) 26362 Immunoglobulin 26362 Tyrosine kinase, catalytic domain 26364 Calcium-binding EGF-like domain 26365 Immunoglobulin C-2 Type 26365 Immunoglobulin 26365 Immunoglobulin C-2 Type 26367 Immunoglobulin 26368 Immunoglobulin 26369 EF-hand, calcium binding motif 26372 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as 26374 Ring finger 26377 Src homology 2 domains 26377 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26379 Ligand binding domain of hormone receptors 26382 Protein present in Fab1, YOTB, Vac1, and EEA1 26382 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 26385 Serine/Threonine protein kinases, catalytic domain 26395 Serine/Threonine protein kinases, catalytic domain 26396 Serine/Threonine protein kinases, catalytic domain 26397 Serine/Threonine protein kinases, catalytic domain 26398 Serine/Threonine protein kinases, catalytic domain 26399 Tyrosine kinase, catalytic domain 26399 erine/Threonine protein kinases, catalytic domain 26399 Serine/Threonine protein kinases, catalytic domain 26400 Serine/Threonine protein kinases, catalytic domain 26403 Src homology 3 domains 26403 Tyrosine kinase, catalytic domain 26403 Src homology 3 domains 26403 Tyrosine kinase, catalytic domain 26403 erine/Threonine protein kinases, catalytic domain 26403 Serine/Threonine protein kinases, catalytic domain 26405 PB1 domain 26405 Serine/Threonine protein kinases, catalytic domain 26406 PB1 domain 26406 Serine/Threonine protein kinases, catalytic domain 26406 PB1 domain 26406 Tyrosine kinase, catalytic domain 26406 erine/Threonine protein kinases, catalytic domain 26406 Serine/Threonine protein kinases, catalytic domain 26407 Serine/Threonine protein kinases, catalytic domain 26408 Serine/Threonine protein kinases, catalytic domain 26410 Serine/Threonine protein kinases, catalytic domain 26411 Tyrosine kinase, catalytic domain 26411 erine/Threonine protein kinases, catalytic domain 26411 Serine/Threonine protein kinases, catalytic domain 26412 Serine/Threonine protein kinases, catalytic domain 26412 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 26412 Tyrosine kinase, catalytic domain 26412 Serine/Threonine protein kinases, catalytic domain 26412 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 26413 Serine/Threonine protein kinases, catalytic domain 26414 Serine/Threonine protein kinases, catalytic domain 26415 Serine/Threonine protein kinases, catalytic domain 26416 Serine/Threonine protein kinases, catalytic domain 26417 Serine/Threonine protein kinases, catalytic domain 26419 Serine/Threonine protein kinases, catalytic domain 26420 Serine/Threonine protein kinases, catalytic domain 26427 basic region leucin zipper 26431 Putative GTP-ase activating proteins for the small GTPase, ARF 26432 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 26433 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 26436 Immunoglobulin 26437 Immunoglobulin 26437 Immunoglobulin C-2 Type 26438 Immunoglobulin C-2 Type 26439 Immunoglobulin C-2 Type 26448 Serine/Threonine protein kinases, catalytic domain 26456 Immunoglobulin 26456 semaphorin domain 26456 domain found in Plexins, Semaphorins and Integrins 26469 Protein tyrosine phosphatase, catalytic domain 26470 Domain abundant in complement control proteins 26470 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 26499 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26508 Orange domain 26509 Protein kinase C conserved region 2 (CalB) 26509 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th 26509 Protein kinase C conserved region 2 (CalB) 26509 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th 26512 von Willebrand factor (vWF) type A domain 26524 Serine/Threonine protein kinases, catalytic domain 26525 Interleukin-1 homologues 26525 Interleukin-1 homologues 26528 RNA recognition motif 26528 RNA recognition motif 26557 WASP homology region 1 26558 WASP homology region 1 26559 Serine/Threonine protein kinases, catalytic domain 26561 ShK toxin domain 26563 Immunoglobulin 26563 Kringle domain 26563 Tyrosine kinase, catalytic domain 26564 Immunoglobulin 26564 Kringle domain 26564 Tyrosine kinase, catalytic domain 26572 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 26576 Serine/Threonine protein kinases, catalytic domain 26577 Netrin C-terminal Domain 26577 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 26578 Src homology 3 domains 26608 WD40 repeats 26750 Serine/Threonine protein kinases, catalytic domain 26751 Src homology 3 domains 26754 JAB/MPN domain 26762 Immunoglobulin V-Type 26875 Protein kinase C conserved region 2 (CalB) 26875 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 26888 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 26889 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 26893 JAB/MPN domain 26893 JAB/MPN domain 26894 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 26895 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 26898 Papain family cysteine protease 26903 Protein kinase C conserved region 2 (CalB) 26903 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th 26904 Src homology 2 domains 26909 Xeroderma pigmentosum G N-region 26914 Histone 2A 26914 Appr-1"-p processing enzyme 26918 Serine/Threonine protein kinases, catalytic domain 26919 U1-like zinc finger 26921 Serine/Threonine protein kinases, catalytic domain 26921 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 26927 FORKHEAD 26934 GTPase-activator protein for Rho-like GTPases 26936 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26941 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 26942 Tetratricopeptide repeats 26942 Tetratricopeptide repeats 26944 Somatomedin B -like domains 26944 von Willebrand factor (vWF) type C domain 26945 Trypsin-like serine protease 26954 Ras subfamily of RAS small GTPases 26955 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 26959 high mobility group 26959 domain in Ataxins and HMG containing proteins 26968 Immunoglobulin 26971 Phospholipase A2 26989 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 26992 bromo domain 26998 Cystatin-like domain 27000 DnaJ molecular chaperone homology domain 27000 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 27006 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 27007 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 27020 Immunoglobulin 27020 Immunoglobulin 27021 FORKHEAD 27028 Immunoglobulin V-Type 27028 associated with SPRY domains 27028 Domain in SPla and the RYanodine Receptor. 27036 Immunoglobulin 27036 Immunoglobulin V-Type 27036 Immunoglobulin 27041 RNA recognition motif 27044 Staphylococcal nuclease homologues 27047 Leucine rich repeat N-terminal domain 27056 interferon regulatory factor 27057 B-Box C-terminal domain 27059 Src homology 3 domains 27062 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 27067 Double-stranded RNA binding motif 27071 Src homology 2 domains 27071 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 27072 Clathrin heavy chain repeat homology 27072 Clathrin heavy chain repeat homology 27076 Ly-6 antigen / uPA receptor -like domain 27080 high mobility group 27080 domain in Ataxins and HMG containing proteins 27086 FORKHEAD 27098 CLUSTERIN alpha chain 27102 Serine/Threonine protein kinases, catalytic domain 27103 Serine/Threonine protein kinases, catalytic domain 27103 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 27103 Tyrosine kinase, catalytic domain 27103 erine/Threonine protein kinases, catalytic domain 27103 Serine/Threonine protein kinases, catalytic domain 27103 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 27104 Tyrosine kinase, catalytic domain 27104 Serine/Threonine protein kinases, catalytic domain 27104 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 27111 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27111 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27124 Inositol polyphosphate phosphatase, catalytic domain homologues 27128 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 27132 von Willebrand factor (vWF) type A domain 27132 von Willebrand factor (vWF) type A domain 27133 Cyclic nucleotide-monophosphate binding domain 27134 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27134 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 27137 Serine/Threonine protein kinases, catalytic domain 27143 Protein tyrosine phosphatase, catalytic domain motif 27148 Serine/Threonine protein kinases, catalytic domain 27150 Cyclic nucleotide-monophosphate binding domain 27151 Kazal type serine protease inhibitors 27152 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27152 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27153 krueppel associated box 27154 bromo domain 27154 PHD zinc finger 27154 domain with conserved PWWP motif 27159 Glyco_18 domain 27159 Chitin-binding domain type 2 27178 Interleukin-1 homologues 27178 Interleukin-1 homologues 27178 Interleukin-1 homologues 27178 Interleukin-1 homologues 27178 Interleukin-1 homologues 27180 Immunoglobulin 27181 Immunoglobulin 27181 Immunoglobulin V-Type 27206 Serine/Threonine protein kinases, catalytic domain 27214 Zinc finger in DBF-like proteins 27219 Serine/Threonine protein kinases, catalytic domain 27223 Tudor domain 27223 Tudor domain 27223 breast cancer carboxy-terminal domain 27224 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 27237 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 27238 glycine rich nucleic binding domain 27242 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 27246 Ring finger 27252 Kelch domain 27253 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 27255 Immunoglobulin 27255 Immunoglobulin C-2 Type 27256 Immunoglobulin 27256 Immunoglobulin C-2 Type 27260 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 27263 RIO-like kinase 27263 Tyrosine kinase, catalytic domain 27263 erine/Threonine protein kinases, catalytic domain 27263 Serine/Threonine protein kinases, catalytic domain 27274 krueppel associated box 27276 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 27278 Src homology 2 domains 27280 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 27283 Somatomedin B -like domains 27283 von Willebrand factor (vWF) type C domain 27286 Domain abundant in complement control proteins 27288 RNA recognition motif 27289 Rho (Ras homology) subfamily of Ras-like small GTPases 27290 Kazal type serine protease inhibitors 27295 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27297 DNA-directed RNA-polymerase II subunit 27299 Homologues of snake disintegrins 27300 krueppel associated box 27302 Transforming growth factor-beta (TGF-beta) family 27303 RNA recognition motif 27304 Rhodanese Homology Domain 27314 Rab subfamily of small GTPases 27316 RNA recognition motif 27324 high mobility group 27327 RNA recognition motif 27327 RNA recognition motif 27328 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 27328 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 27328 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 27328 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 27329 Fibrinogen-related domains (FReDs) 27330 Serine/Threonine protein kinases, catalytic domain 27330 Serine/Threonine protein kinases, catalytic domain 27332 U1-like zinc finger 27332 RNA recognition motif 27336 RNA recognition motif 27339 Modified RING finger domain 27341 RNA recognition motif 27342 A20-like zinc fingers 27343 DNA polymerase X family 27347 Serine/Threonine protein kinases, catalytic domain 27352 Src homology 3 domains 27352 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 27355 Protein tyrosine phosphatase, catalytic domain motif 27371 Src homology 2 domains 27375 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27375 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 27386 PAS domain 27386 helix loop helix domain 27387 Src homology 2 domains 27387 Guanine nucleotide exchange factor for Ras-like small GTPases 27389 Dual specificity phosphatase, catalytic domain 27401 A Receptor for Ubiquitination Targets 27406 ATPases associated with a variety of cellular activities 27423 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 27424 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 27428 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27433 ATPases associated with a variety of cellular activities 27434 DNA polymerase X family 27445 Protein kinase C conserved region 2 (CalB) 27445 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 27632 RNA recognition motif 27756 snRNP Sm proteins 27756 snRNP Sm proteins 27967 glycine rich nucleic binding domain 27967 Suppressor-of-White-APricot splicing regulator 27967 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 27967 Suppressor-of-White-APricot splicing regulator 27979 RNA recognition motif 27979 RNA recognition motif 28000 Modified RING finger domain 28018 Ubiquitin homologues 28035 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 28105 B-Box C-terminal domain 28105 Fibronectin type 3 domain 28105 Domain in SPla and the RYanodine Receptor. 28169 Phosphate acyltransferases 28231 Kazal type serine protease inhibitors 28234 Kazal type serine protease inhibitors 28316 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 28513 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 28514 Calcium-binding EGF-like domain 28951 Serine/Threonine protein kinases, catalytic domain 28954 Ras subfamily of RAS small GTPases 28964 Putative GTP-ase activating proteins for the small GTPase, ARF 28964 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins 28983 Trypsin-like serine protease 28988 Src homology 3 domains 28988 Actin depolymerisation factor/cofilin -like domains 28990 Xeroderma pigmentosum G N-region 28996 Serine/Threonine protein kinases, catalytic domain 29028 bromo domain 29068 Broad-Complex, Tramtrack and Bric a brac 29072 Domain with 2 conserved Trp (W) residues 29094 Galectin 29102 Ribonuclease III family 29109 Formin Homology 2 Domain 29110 Serine/Threonine protein kinases, catalytic domain 29117 bromo domain 29121 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 29122 Trypsin-like serine protease 29126 Immunoglobulin 29127 GTPase-activator protein for Rho-like GTPases 29128 Ring finger 29134 Domain present in Dishevelled and axin 29134 Regulator of G protein signalling domain 29135 Scavenger receptor Cys-rich 29135 Trypsin-like serine protease 29139 Leucine rich repeat N-terminal domain 29141 Galanin 29143 Granulin 29146 von Willebrand factor (vWF) type C domain 29147 delta serrate ligand 29147 von Willebrand factor (vWF) type C domain 29150 U1-like zinc finger 29150 RNA recognition motif 29152 Transforming growth factor-beta (TGF-beta) family 29157 domain present in cyclins, TFIIB and Retinoblastoma 29158 Calcium-binding EGF-like domain 29162 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 29163 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 29165 Trypsin-like serine protease 29168 Ubiquitin homologues 29169 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 29175 Papain family cysteine protease 29182 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 29199 Immunoglobulin C-Type 29200 Transforming growth factor-beta (TGF-beta) family 29202 Ephrin receptor ligand binding domain 29203 FORKHEAD 29210 Fibronectin type 3 domain 29210 Tyrosine kinase, catalytic domain 29210 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 29211 Spectrin repeats 29211 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 29216 Low-density lipoprotein-receptor YWTD domain 29216 Low-density lipoprotein receptor domain class A 29231 WD40 repeats 29240 DNA polymerase X family 29243 Trypsin-like serine protease 29243 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 29245 Trypsin-like serine protease 29251 Kringle domain 29251 Trypsin-like serine protease 29251 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 29252 Trypsin-like serine protease 29259 Domain abundant in complement control proteins 29265 Trypsin-like serine protease 29266 Trypsin-like serine protease 29268 Trypsin-like serine protease 29269 Trypsin-like serine protease 29271 Actin depolymerisation factor/cofilin -like domains 29278 Src homology 3 domains 29278 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 29300 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 29313 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 29321 RNA recognition motif 29322 Phospholipase C, catalytic domain (part) 29322 Protein kinase C conserved region 2 (CalB) 29331 Immunoglobulin V-Type 29333 Domain abundant in complement control proteins 29337 Src homology 2 domains 29337 Phospholipase C, catalytic domain (part) 29337 Phospholipase C, catalytic domain (part) 29337 Protein kinase C conserved region 2 (CalB) 29339 Pentraxin / C-reactive protein / pentaxin family 29340 Tyrosine kinase, catalytic domain 29340 Serine/Threonine protein kinases, catalytic domain 29340 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 29352 K homology RNA-binding domain 29353 Serine/Threonine protein kinases, catalytic domain 29354 Phospholipase A2 29355 Extension to Ser/Thr-type protein kinases 29355 Serine/Threonine protein kinases, catalytic domain 29356 Pancreatic ribonuclease 29362 basic region leucin zipper 29365 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 29366 SERine Proteinase INhibitors 29371 K homology RNA-binding domain 29373 Transforming growth factor-beta (TGF-beta) family 29381 Tyrosine kinase, catalytic domain 29381 Serine/Threonine protein kinases, catalytic domain 29384 Histone 2A 29386 Methyl-CpG binding domain 29387 Phospholipase A2 29390 TopoisomeraseII 29390 DNA Topoisomerase IV 29397 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 29409 Immunoglobulin 29409 Immunoglobulin C-2 Type 29414 Serine/Threonine protein kinases, catalytic domain 29414 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 29426 S4 RNA-binding domain 29428 RNA recognition motif 29431 Serine/Threonine protein kinases, catalytic domain 29432 Serine/Threonine protein kinases, catalytic domain 29433 Serine/Threonine protein kinases, catalytic domain 29434 Guanine nucleotide exchange factor for Ras-like GTPases 29434 Guanine nucleotide exchange factor for Ras-like small GTPases 29436 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 29448 Rab subfamily of small GTPases 29452 PAS domain 29452 helix loop helix domain 29455 Transforming growth factor-beta (TGF-beta) family 29481 G protein gamma subunit-like motifs 29481 Regulator of G protein signalling domain 29481 Domain found in Dishevelled, Egl-10, and Pleckstrin 29484 Alpha-amylase domain 29491 Eps15 homology domain 29491 Src homology 3 domains 29492 Calcium-binding EGF-like domain 29492 Domain found in Notch and Lin-12 29495 Src homology 3 domains 29495 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 29495 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 29496 Furin-like repeats 29496 Tyrosine kinase, catalytic domain 29497 RNA recognition motif 29508 CCAAT-Binding transcription Factor 29510 in StAR and phosphatidylcholine transfer protein 29513 Serine/Threonine protein kinases, catalytic domain 29517 Serine/Threonine protein kinases, catalytic domain 29518 Galectin 29532 AN1-like Zinc finger 29532 Putative single-stranded nucleic acids-binding domain 29538 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 29541 endonuclease III 29541 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3) 29555 Domain present in hormone receptors 29558 Immunoglobulin C-Type 29559 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 29560 PAS domain 29561 Immunoglobulin 29561 Immunoglobulin C-2 Type 29567 Orange domain 29568 PB1 domain 29568 Serine/Threonine protein kinases, catalytic domain 29569 Netrin C-terminal Domain 29569 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 29575 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 29575 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 29576 von Willebrand factor (vWF) type C domain 29577 Orange domain 29578 RNA recognition motif 29579 Protein kinase C conserved region 2 (CalB) 29589 Found in Pit-Oct-Unc transcription factors 29591 GS motif 29602 Immunoglobulin 29602 Immunoglobulin V-Type 29603 Histidine kinase-like ATPases 29613 Immunoglobulin 29613 Immunoglobulin C-2 Type 29613 Tyrosine kinase, catalytic domain 29613 Leucine rich repeat C-terminal domain 29615 Immunoglobulin 29615 Immunoglobulin C-2 Type 29615 Fibronectin type 3 domain 29615 Fibronectin type 3 domain 29615 Protein tyrosine phosphatase, catalytic domain 29616 Protein tyrosine phosphatase, catalytic domain 29616 Protein tyrosine phosphatase, catalytic domain motif 29617 Fibronectin type 3 domain 29617 Protein tyrosine phosphatase, catalytic domain 29622 Guanine nucleotide exchange factor for Ras-like GTPases 29622 Guanine nucleotide exchange factor for Ras-like small GTPases 29627 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 29628 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 29629 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 29631 Helical region found in SNAREs 29641 ADAM Cysteine-Rich Domain 29641 Homologues of snake disintegrins 29644 Protein tyrosine phosphatase, catalytic domain 29645 Fibronectin type 3 domain 29645 Fibronectin type 3 domain 29645 Protein tyrosine phosphatase, catalytic domain 29647 Src homology 3 domains 29647 Serine/Threonine protein kinases, catalytic domain 29647 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 29657 PAS domain 29660 Serine/Threonine protein kinases, catalytic domain 29679 Cystatin-like domain 29683 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 29684 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 29685 minichromosome maintenance proteins 29687 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 29692 Phospholipase A2 29699 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 29699 Cyclic nucleotide-monophosphate binding domain 29702 Serine/Threonine protein kinases, catalytic domain 29704 Src homology 3 domains 29704 Fes/CIP4 homology domain 29714 Protein tyrosine phosphatase, catalytic domain 29715 Domains in Na-Ca exchangers and integrin-beta4 29741 Src homology 2 domains 29741 GTPase-activator protein for Rho-like GTPases 29744 semaphorin domain 29745 semaphorin domain 29745 domain found in Plexins, Semaphorins and Integrins 29750 Ricin-type beta-trefoil 29751 domain found in Plexins, Semaphorins and Integrins 29752 Ubiquitin homologues 29760 Src homology 2 domains 29763 Src homology 3 domains 29763 Fes/CIP4 homology domain 29780 Calponin homology domain 29802 Immunoglobulin V-Type 29806 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 29808 Domain first found in the mice T locus (Brachyury) protein 29809 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 29809 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 29809 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 29810 Domain with 2 conserved Trp (W) residues 29813 U1-like zinc finger 29815 Src homology 2 domains 29815 Guanine nucleotide exchange factor for Ras-like small GTPases 29816 I/LWEQ domain 29816 Epsin N-terminal homology (ENTH) domain 29817 Immunoglobulin 29817 Insulin growth factor-binding protein homologues 29857 Serine/Threonine protein kinases, catalytic domain 29861 PHD zinc finger 29869 Serine/Threonine protein kinases, catalytic domain 29871 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 29875 GTPase-activator protein for Ras-like GTPases 29890 RNA recognition motif 29890 RNA recognition motif 29896 RNA recognition motif 29899 LGN motif, putative GEFs specific for G-alpha GTPases 29924 Epsin N-terminal homology (ENTH) domain 29930 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 29941 Serine/Threonine protein kinases, catalytic domain 29942 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 29957 Eps15 homology domain 29959 Serine/Threonine protein kinases, catalytic domain 29964 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 29965 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins 29967 Low-density lipoprotein receptor domain class A 29974 RNA recognition motif 29974 RNA recognition motif 29974 RNA recognition motif 29978 Ubiquitin associated domain 29979 Ubiquitin associated domain 29979 Ubiquitin associated domain 29984 Rho (Ras homology) subfamily of Ras-like small GTPases 29990 Immunoglobulin 29990 Immunoglobulin 29992 Immunoglobulin 29992 Immunoglobulin 29992 Immunoglobulin 29993 Src homology 3 domains 29993 Fes/CIP4 homology domain 29994 bromo domain 29994 domain in different transcription and chromosome remodeling factors 29995 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 30008 Calcium-binding EGF-like domain 30009 Domain first found in the mice T locus (Brachyury) protein 30011 Src homology 3 domains 30051 SAM / Pointed domain 30051 erythroblast transformation specific domain 30054 B-Box C-terminal domain 30060 Transferrin 30800 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 30806 ADAM Cysteine-Rich Domain 30806 Thrombospondin type 1 repeats 30811 Serine/Threonine protein kinases, catalytic domain 30817 Calcium-binding EGF-like domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30817 Calcium-binding EGF-like domain 30817 G-protein-coupled receptor proteolytic site domain 30818 Eps15 homology domain 30818 EF-hand, calcium binding motif 30819 Eps15 homology domain 30819 EF-hand, calcium binding motif 30819 Eps15 homology domain 30819 EF-hand, calcium binding motif 30819 Eps15 homology domain 30819 EF-hand, calcium binding motif 30819 EF-hand, calcium binding motif 30819 EF-hand, calcium binding motif 30819 Eps15 homology domain 30819 EF-hand, calcium binding motif 30820 Eps15 homology domain 30820 EF-hand, calcium binding motif 30826 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 30832 krueppel associated box 30832 krueppel associated box 30835 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 30837 Src homology 2 domains 30837 suppressors of cytokine signalling 30839 WD40 repeats 30839 A Receptor for Ubiquitination Targets 30841 A Receptor for Ubiquitination Targets 30844 Eps15 homology domain 30845 Eps15 homology domain 30846 Eps15 homology domain 30849 Serine/Threonine protein kinases, catalytic domain 30851 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 30924 Fibrinogen-related domains (FReDs) 30924 Fibrinogen-related domains (FReDs) 30937 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 30938 Protein present in Fab1, YOTB, Vac1, and EEA1 30938 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 30938 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 30943 Trypsin-like serine protease 30944 krueppel associated box 30945 In Between Ring fingers 30945 In Between Ring fingers 30947 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 30948 Src homology 3 domains 30952 Cyclic nucleotide-monophosphate binding domain 30955 PI3-kinase family, Ras-binding domain 30955 Phosphoinositide 3-kinase, catalytic domain 43847 Trypsin-like serine protease 43849 Trypsin-like serine protease 43849 Trypsin-like serine protease 43849 Trypsin-like serine protease 49855 U1-like zinc finger 50487 Phospholipase A2 50488 Serine/Threonine protein kinases, catalytic domain 50488 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 50488 Serine/Threonine protein kinases, catalytic domain 50488 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 50488 Serine/Threonine protein kinases, catalytic domain 50488 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 50489 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 50498 Fibronectin type 3 domain 50500 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 50509 Fibrillar collagens C-terminal domain 50509 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 50523 Serine/Threonine protein kinases, catalytic domain 50528 Scavenger receptor Cys-rich 50528 Trypsin-like serine protease 50528 Scavenger receptor Cys-rich 50528 Trypsin-like serine protease 50528 Low-density lipoprotein receptor domain class A 50545 PHD zinc finger 50546 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 50567 Alpha-amylase domain 50570 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 50592 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 50604 Interleukin-10 family 50613 Ubiquitin associated domain 50614 Ricin-type beta-trefoil 50618 Eps15 homology domain 50618 Src homology 3 domains 50618 Protein kinase C conserved region 2 (CalB) 50618 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 50618 Eps15 homology domain 50618 Src homology 3 domains 50618 Protein kinase C conserved region 2 (CalB) 50618 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 50618 Eps15 homology domain 50618 Src homology 3 domains 50619 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 50624 Zona pellucida (ZP) domain 50624 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 50646 Band 4.1 homologues 50646 Tyrosine kinase, catalytic domain 50649 Src homology 3 domains 50649 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 50649 Src homology 3 domains 50649 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 50650 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 50658 Serine/Threonine protein kinases, catalytic domain 50677 Protein tyrosine phosphatase, catalytic domain 50683 Pulmonary surfactant proteins 50686 Serine/Threonine protein kinases, catalytic domain 50687 Immunoglobulin 50687 Immunoglobulin C-2 Type 50688 Src homology 3 domains 50689 Serine/Threonine protein kinases, catalytic domain 50692 Ly-6 antigen / uPA receptor -like domain 50692 Ly-6 antigen / uPA receptor -like domain 50693 Vault protein Inter-alpha-Trypsin domain 50693 von Willebrand factor (vWF) type A domain 50701 Trypsin-like serine protease 50702 Domain abundant in complement control proteins 50706 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 50723 Immunoglobulin V-Type 50753 Sec7 domain 50760 A Receptor for Ubiquitination Targets 50766 von Willebrand factor (vWF) type C domain 50766 Insulin growth factor-binding protein homologues 50768 GTPase-activator protein for Rho-like GTPases 50768 in StAR and phosphatidylcholine transfer protein 50768 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 50772 Serine/Threonine protein kinases, catalytic domain 50778 Regulator of G protein signalling domain 50779 G protein gamma subunit-like motifs 50779 G protein gamma subunit-like motifs 50779 Regulator of G protein signalling domain 50779 Domain found in Dishevelled, Egl-10, and Pleckstrin 50780 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 50782 G protein gamma subunit-like motifs 50782 Regulator of G protein signalling domain 50782 Domain found in Dishevelled, Egl-10, and Pleckstrin 50783 snRNP Sm proteins 50789 A Receptor for Ubiquitination Targets 50791 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 50791 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 50791 Domain with 2 conserved Trp (W) residues 50791 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 50791 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 50796 Doublesex DNA-binding motif 50797 WD40 repeats 50804 RNA recognition motif 50805 Homeodomain 50809 Domain in histone families 1 and 5 50813 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 50817 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 50846 Hint (Hedgehog/Intein) domain N-terminal region 50848 Immunoglobulin 50848 Immunoglobulin 50848 Immunoglobulin 50848 Immunoglobulin 50848 Immunoglobulin 50849 Ring finger 50850 ATPases associated with a variety of cellular activities 50853 Villin headpiece domain 50853 Gelsolin homology domain 50855 PB1 domain 50855 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 50856 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 50859 Kazal type serine protease inhibitors 50863 Immunoglobulin 50863 Immunoglobulin C-2 Type 50864 Immunoglobulin 50864 Immunoglobulin C-2 Type 50866 Rab subfamily of small GTPases 50868 Kelch domain 50883 Serine/Threonine protein kinases, catalytic domain 50908 Trypsin-like serine protease 50908 Calcium-binding EGF-like domain 50908 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 50909 Trypsin-like serine protease 50909 Calcium-binding EGF-like domain 50909 Domain abundant in complement control proteins 50909 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 50912 3'-5' exonuclease 50912 Helicase and RNase D C-terminal 50915 Src homology 2 domains 50915 Ras association (RalGDS/AF-6) domain 50915 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 50916 Homeodomain 50926 RNA recognition motif 50928 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 50930 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 50932 Serine/Threonine protein kinases, catalytic domain 50932 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 50932 Serine/Threonine protein kinases, catalytic domain 50932 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 50932 Tyrosine kinase, catalytic domain 50932 erine/Threonine protein kinases, catalytic domain 50932 Serine/Threonine protein kinases, catalytic domain 50932 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 50937 Immunoglobulin 50937 Immunoglobulin C-2 Type 50938 Immunoglobulin 50938 Immunoglobulin C-2 Type 50939 Domain found in sea urchin sperm protein, enterokinase, agrin 50940 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 50943 FORKHEAD 50944 Src homology 3 domains 50944 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 50945 Domain first found in the mice T locus (Brachyury) protein 50997 Src homology 3 domains 50997 domain in receptor targeting proteins Lin-2 and Lin-7 50997 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 50997 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 51008 K homology RNA-binding domain 51032 Trypsin-like serine protease 51035 Domain present in ubiquitin-regulatory proteins 51050 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 51070 Modified RING finger domain 51078 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 51083 Galanin 51086 Tyrosine kinase, catalytic domain 51100 BAR domain 51100 Src homology 3 domains 51105 Tudor domain 51105 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 51111 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 51111 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 51127 associated with SPRY domains 51128 Sar1p-like members of the Ras-family of small GTPases 51129 Fibrinogen-related domains (FReDs) 51129 Fibrinogen-related domains (FReDs) 51130 ankyrin repeats 51130 suppressors of cytokine signalling 51130 ankyrin repeats 51130 suppressors of cytokine signalling 51168 Band 4.1 homologues 51168 Src homology 3 domains 51168 Myosin. Large ATPases. ATPase 51168 Domain in Myosin and Kinesin Tails 51177 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 51191 Domain Homologous to E6-AP Carboxyl Terminus with 51195 Guanine nucleotide exchange factor for Ras-like small GTPases 51196 Ras association (RalGDS/AF-6) domain 51196 Phospholipase C, catalytic domain (part) 51196 Phospholipase C, catalytic domain (part) 51196 Guanine nucleotide exchange factor for Ras-like small GTPases 51200 Zn_pept domain 51207 Dual specificity phosphatase, catalytic domain 51224 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 51224 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 51225 Src homology 3 domains 51230 Tudor domain 51230 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 51248 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 51265 Serine/Threonine protein kinases, catalytic domain 51266 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 51267 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 51277 Rab subfamily of small GTPases 51279 Trypsin-like serine protease 51279 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 51282 leucine rich region 51282 leucine rich region 51283 Ring finger 51283 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 51285 Ras subfamily of RAS small GTPases 51291 Fes/CIP4 homology domain 51291 GTPase-activator protein for Rho-like GTPases 51291 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 51293 Low-density lipoprotein receptor domain class A 51294 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 51306 GTPase-activator protein for Rho-like GTPases 51311 Leucine rich repeat C-terminal domain 51311 Leucine rich repeat C-terminal domain 51314 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 51322 Domain with 2 conserved Trp (W) residues 51322 Domain with 2 conserved Trp (W) residues 51322 Domain with 2 conserved Trp (W) residues 51326 ARF-like small GTPases 51332 Spectrin repeats 51332 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 51347 Serine/Threonine protein kinases, catalytic domain 51348 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 51366 Domain Homologous to E6-AP Carboxyl Terminus with 51366 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 51366 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 51378 Fibrinogen-related domains (FReDs) 51379 Fibronectin type 3 domain 51389 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 51412 Actin 51429 Src homology 3 domains 51460 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 51460 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 51460 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 51473 Domain in the Doublecortin (DCX) gene product 51479 Protein present in Fab1, YOTB, Vac1, and EEA1 51513 SAM / Pointed domain 51513 erythroblast transformation specific domain 51517 Src homology 3 domains 51552 Rab subfamily of small GTPases 51585 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 51588 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 51592 bromo domain 51592 B-Box C-terminal domain 51592 bromo domain 51592 B-Box C-terminal domain 51639 RNA recognition motif 51655 Ras subfamily of RAS small GTPases 51657 Rhodanese Homology Domain 51665 suppressors of cytokine signalling 51667 Ubiquitin associated domain 51676 suppressors of cytokine signalling 51677 Serine/Threonine protein kinases, catalytic domain 51678 Src homology 3 domains 51678 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 51690 snRNP Sm proteins 51701 Serine/Threonine protein kinases, catalytic domain 51711 krueppel associated box 51735 Ras association (RalGDS/AF-6) domain 51735 Guanine nucleotide exchange factor for Ras-like GTPases 51735 Guanine nucleotide exchange factor for Ras-like small GTPases 51735 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 51741 Domain with 2 conserved Trp (W) residues 51741 Domain with 2 conserved Trp (W) residues 51741 Domain with 2 conserved Trp (W) residues 51741 Domain with 2 conserved Trp (W) residues 51741 Domain with 2 conserved Trp (W) residues 51741 Domain with 2 conserved Trp (W) residues 51742 Tudor domain 51742 Tudor domain 51755 Serine/Threonine protein kinases, catalytic domain 51760 Protein kinase C conserved region 2 (CalB) 51763 Inositol polyphosphate phosphatase, catalytic domain homologues 51763 Inositol polyphosphate phosphatase, catalytic domain homologues 51764 G protein gamma subunit-like motifs 51765 Serine/Threonine protein kinases, catalytic domain 51776 Tyrosine kinase, catalytic domain 51776 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 51788 Histone 2A 51789 Src homology 3 domains 51789 Tyrosine kinase, catalytic domain 51791 Regulator of G protein signalling domain 51795 Domain abundant in complement control proteins 51804 Homeodomain 51809 Ricin-type beta-trefoil 51886 K homology RNA-binding domain 51960 Broad-Complex, Tramtrack and Bric a brac 52020 Zona pellucida (ZP) domain 52040 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 52040 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 52118 Immunoglobulin 52118 Immunoglobulin 52118 Immunoglobulin V-Type 52123 Phosphate acyltransferases 52163 Serine/Threonine protein kinases, catalytic domain 52202 RNA recognition motif 52428 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 52635 Protein kinase C conserved region 2 (CalB) 52637 CDGSH-type zinc finger. Function unknown 52662 Low-density lipoprotein receptor domain class A 52666 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 52685 Immunoglobulin 52712 leucine rich region 52712 krueppel associated box 52850 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 52906 Src homology 3 domains 52906 WD40 repeats 52906 Src homology 3 domains 53310 Src homology 3 domains 53310 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 53310 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 53311 Immunoglobulin 53311 Fibronectin type 3 domain 53312 Ubiquitin associated domain 53314 basic region leucin zipper 53318 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 53321 Laminin G domain 53323 Ubiquitin associated domain 53323 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 53324 Pentraxin / C-reactive protein / pentaxin family 53332 Protein tyrosine phosphatase, catalytic domain motif 53332 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 53340 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 53345 Immunoglobulin 53347 Src homology 3 domains 53349 Protein present in Fab1, YOTB, Vac1, and EEA1 53349 Protein present in Fab1, YOTB, Vac1, and EEA1 53349 Protein present in Fab1, YOTB, Vac1, and EEA1 53353 Low-density lipoprotein-receptor YWTD domain 53353 Low-density lipoprotein receptor domain class A 53353 Low-density lipoprotein receptor domain class A 53356 RNA recognition motif 53358 Src homology 2 domains 53378 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 53379 RNA recognition motif 53379 RNA recognition motif 53404 helix loop helix domain 53416 Serine/Threonine protein kinases, catalytic domain 53417 PAS domain 53417 helix loop helix domain 53417 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 53419 Trypsin-like serine protease 53419 Low-density lipoprotein receptor domain class A 53420 Protein kinase C conserved region 2 (CalB) 53601 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 53604 Immunoglobulin 53606 Ubiquitin homologues 53606 Ubiquitin homologues 53607 RNA recognition motif 53608 Serine/Threonine protein kinases, catalytic domain 53610 RNA recognition motif 53612 Helical region found in SNAREs 53616 ADAM Cysteine-Rich Domain 53616 Homologues of snake disintegrins 53616 ADAM Cysteine-Rich Domain 53616 Homologues of snake disintegrins 53616 ADAM Cysteine-Rich Domain 53616 Homologues of snake disintegrins 53616 ADAM Cysteine-Rich Domain 53616 Homologues of snake disintegrins 53616 ADAM Cysteine-Rich Domain 53616 Homologues of snake disintegrins 53618 Src homology 3 domains 53623 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 53817 DEAD-like helicases superfamily 53817 helicase superfamily c-terminal domain 53817 DEAD-like helicases superfamily 53817 helicase superfamily c-terminal domain 53834 Immunoglobulin 53834 Immunoglobulin C-2 Type 53840 Domain in SPla and the RYanodine Receptor. 53840 Domain in SPla and the RYanodine Receptor. 53841 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 53841 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 53841 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 53856 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 53858 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 53859 Serine/Threonine protein kinases, catalytic domain 53861 Zinc finger domain 53867 Fibrillar collagens C-terminal domain 53867 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 53868 Rab subfamily of small GTPases 53869 Rab subfamily of small GTPases 53870 Immunoglobulin 53870 Immunoglobulin C-2 Type 53876 Pancreatic ribonuclease 53877 Pancreatic ribonuclease 53883 Laminin G domain 53883 Domain present in hormone receptors 53883 G-protein-coupled receptor proteolytic site domain 53883 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 53886 Serine/Threonine protein kinases, catalytic domain 53890 RNA recognition motif 53892 Serine/threonine phosphatases, family 2C, catalytic domain 53904 Myosin. Large ATPases. ATPase 53904 Serine/Threonine protein kinases, catalytic domain 53916 Rab subfamily of small GTPases 53942 Immunoglobulin 53942 Immunoglobulin C-2 Type 53942 Immunoglobulin 53942 Immunoglobulin C-2 Type 53942 Fibronectin type 3 domain 53951 glycine rich nucleic binding domain 53972 Src homology 3 domains 53972 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 54003 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 54004 Formin Homology 2 Domain 54014 bromo domain 54014 bromo domain 54033 RNA recognition motif 54039 K homology RNA-binding domain 54084 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 54120 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54122 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 54123 interferon regulatory factor 54125 DNA polymerase X family 54126 Src homology 3 domains 54126 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 54126 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 54130 Actin 54131 interferon regulatory factor 54139 interferon regulatory factor 54139 interferon regulatory factor 54156 Calcium-binding EGF-like domain 54156 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 54159 Pancreatic ribonuclease 54169 Domain in histone families 1 and 5 54188 zinc finger 54196 RNA recognition motif 54210 Immunoglobulin V-Type 54212 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54212 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 54215 Immunoglobulin 54216 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 54221 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54226 amyloid A4 54226 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 54237 Serine/Threonine protein kinases, catalytic domain 54241 Clathrin heavy chain repeat homology 54243 Domain abundant in complement control proteins 54245 Src homology 3 domains 54248 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 54249 Trypsin-like serine protease 54251 Immunoglobulin 54251 Tyrosine kinase, catalytic domain 54252 Ring finger 54252 B-Box-type zinc finger 54252 B-Box C-terminal domain 54252 Fibronectin type 3 domain 54252 associated with SPRY domains 54252 Domain in SPla and the RYanodine Receptor. 54254 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 54257 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 54259 Src homology 2 domains 54259 Inositol polyphosphate phosphatase, catalytic domain homologues 54264 basic region leucin zipper 54269 Trypsin-like serine protease 54270 Trypsin-like serine protease 54271 Trypsin-like serine protease 54272 Trypsin-like serine protease 54279 Immunoglobulin 54279 Immunoglobulin C-2 Type 54279 Fibronectin type 3 domain 54286 Tyrosine kinase, catalytic domain 54286 Extension to Ser/Thr-type protein kinases 54286 Serine/Threonine protein kinases, catalytic domain 54287 Double-stranded RNA binding motif 54287 Serine/Threonine protein kinases, catalytic domain 54290 Regulator of G protein signalling domain 54292 Regulator of G protein signalling domain 54292 LGN motif, putative GEFs specific for G-alpha GTPases 54292 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54293 Regulator of G protein signalling domain 54293 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54294 Regulator of G protein signalling domain 54295 G protein gamma subunit-like motifs 54295 Regulator of G protein signalling domain 54295 Domain found in Dishevelled, Egl-10, and Pleckstrin 54296 G protein gamma subunit-like motifs 54297 Regulator of G protein signalling domain 54308 Serine/Threonine protein kinases, catalytic domain 54309 Protein kinase C conserved region 2 (CalB) 54314 Calcium-binding EGF-like domain 54314 Domain abundant in complement control proteins 54319 Band 4.1 homologues 54324 Src homology 3 domains 54324 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 54324 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 54348 Serine/Threonine protein kinases, catalytic domain 54352 Homeodomain 54353 Src homology 3 domains 54353 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 54354 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 54355 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 54369 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 54384 Protein tyrosine phosphatase, catalytic domain motif 54393 Domain abundant in complement control proteins 54394 Fibronectin type 3 domain 54404 Vault protein Inter-alpha-Trypsin domain 54404 von Willebrand factor (vWF) type A domain 54410 DNA/RNA non-specific endonuclease 54418 Formin Homology 2 Domain 54426 Fibronectin type 2 domain 54426 Trypsin-like serine protease 54436 Src homology 3 domains 54437 semaphorin domain 54437 Thrombospondin type 1 repeats 54437 domain found in Plexins, Semaphorins and Integrins 54439 RNA recognition motif 54440 Src homology 3 domains 54440 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 54443 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 54446 ig-like, plexins, transcription factors 54446 ig-like, plexins, transcription factors 54448 Interleukin-1 homologues 54450 Interleukin-1 homologues 54453 Domain present in VPS9 54454 bromo domain 54455 A Receptor for Ubiquitination Targets 54461 WD40 repeats 54461 A Receptor for Ubiquitination Targets 54461 WD40 repeats 54461 A Receptor for Ubiquitination Targets 54461 WD40 repeats 54461 A Receptor for Ubiquitination Targets 54467 ankyrin repeats 54467 In Between Ring fingers 54469 A20-like zinc fingers 54472 Protein kinase C conserved region 2 (CalB) 54472 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 54473 Protein kinase C conserved region 2 (CalB) 54473 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 54477 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 54502 RNA recognition motif 54509 Rho (Ras homology) subfamily of Ras-like small GTPases 54510 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 54518 Ras association (RalGDS/AF-6) domain 54518 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 54519 Ras association (RalGDS/AF-6) domain 54519 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 54525 Protein kinase C conserved region 2 (CalB) 54531 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 54538 Immunoglobulin 54538 Immunoglobulin C-2 Type 54549 Immunoglobulin 54581 leucine rich region 54581 leucine rich region 54581 leucine rich region 54581 leucine rich region 54581 leucine rich region 54581 leucine rich region 54583 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 54584 WD40 repeats 54598 Domain present in hormone receptors 54601 FORKHEAD 54607 Src homology 2 domains 54607 suppressors of cytokine signalling 54609 Ubiquitin associated domain 54612 Frizzled 54612 Netrin C-terminal Domain 54614 Contains two conserved F residues 54621 Immunoglobulin 54625 Appr-1"-p processing enzyme 54625 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 54626 Orange domain 54626 helix loop helix domain 54630 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 54631 Immunoglobulin 54631 Immunoglobulin C-2 Type 54634 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54635 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 54635 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 54650 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 54650 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 54662 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 54673 BAR domain 54673 Src homology 3 domains 54673 BAR domain 54673 Src homology 3 domains 54674 Immunoglobulin 54678 krueppel associated box 54681 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 54681 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 54698 Immunoglobulin 54702 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 54712 semaphorin domain 54712 ig-like, plexins, transcription factors 54712 domain found in Plexins, Semaphorins and Integrins 54715 RRM_1 domain 54715 RNA recognition motif 54715 RNA recognition motif 54715 RNA recognition motif 54715 RNA recognition motif 54718 Immunoglobulin V-Type 54718 associated with SPRY domains 54721 Band 4.1 homologues 54721 Tyrosine kinase, catalytic domain 54723 glycine rich nucleic binding domain 54725 Immunoglobulin 54729 Homeodomain 54734 ARF-like small GTPases 54734 Rab subfamily of small GTPases 54734 Ras subfamily of RAS small GTPases 54734 Sar1p-like members of the Ras-family of small GTPases 54734 Rho (Ras homology) subfamily of Ras-like small GTPases 54734 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 54737 ankyrin repeats 54737 Chromatin organization modifier domain 54749 Ependymins 54751 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 54751 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 54760 Furin-like repeats 54763 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 54764 Zinc finger domain 54769 Ras subfamily of RAS small GTPases 54798 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 54799 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 54802 U1-like zinc finger 54806 Src homology 3 domains 54810 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 54823 Large family of predicted nucleotide-binding domains 54825 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 54834 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 54836 associated with SPRY domains 54836 Domain in SPla and the RYanodine Receptor. 54845 RNA recognition motif 54848 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 54861 Serine/Threonine protein kinases, catalytic domain 54862 Protein kinase C conserved region 2 (CalB) 54862 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 54869 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 54869 Src homology 3 domains 54869 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 54874 Src homology 3 domains 54877 zinc finger 54882 K homology RNA-binding domain 54899 Serine/Threonine protein kinases, catalytic domain 54904 domain with conserved PWWP motif 54910 Immunoglobulin 54910 semaphorin domain 54910 domain found in Plexins, Semaphorins and Integrins 54925 krueppel associated box 54947 Phosphate acyltransferases 54984 glycine rich nucleic binding domain 54986 Serine/Threonine protein kinases, catalytic domain 54993 leucine rich region 54994 C-terminal to LisH motif. 54994 Lissencephaly type-1-like homology motif 55008 Domain Homologous to E6-AP Carboxyl Terminus with 55014 Helical region found in SNAREs 55022 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 55023 bromo domain 55030 A Receptor for Ubiquitination Targets 55040 Epsin N-terminal homology (ENTH) domain 55041 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55068 RNA recognition motif 55072 In Between Ring fingers 55074 domain in TBC and LysM domain containing proteins 55080 Immunoglobulin 55080 Immunoglobulin C-Type 55095 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 55103 Guanine nucleotide exchange factor for Ras-like small GTPases 55103 Guanine nucleotide exchange factor for Ras-like small GTPases 55114 BAR domain 55114 GTPase-activator protein for Rho-like GTPases 55128 Ring finger 55128 associated with SPRY domains 55128 Domain in SPla and the RYanodine Receptor. 55130 Armadillo/beta-catenin-like repeats 55131 RNA recognition motif 55132 Domain in the RNA-binding Lupus La protein 55132 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 55132 Domain in the RNA-binding Lupus La protein 55132 Domain in the RNA-binding Lupus La protein 55132 Domain in the RNA-binding Lupus La protein 55132 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 55133 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 55139 U1-like zinc finger 55145 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 55147 RNA recognition motif 55156 Armadillo/beta-catenin-like repeats 55160 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 55171 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 55192 RNA recognition motif 55193 high mobility group 55193 bromo domain 55193 high mobility group 55197 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 55198 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 55200 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 55206 DEAD-like helicases superfamily 55213 Broad-Complex, Tramtrack and Bric a brac 55214 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 55220 Kelch domain 55223 Ring finger 55223 B-Box C-terminal domain 55223 associated with SPRY domains 55223 Domain in SPla and the RYanodine Receptor. 55234 C-terminal to LisH motif. 55234 Lissencephaly type-1-like homology motif 55243 Immunoglobulin 55269 RNA recognition motif 55285 RNA recognition motif 55288 Rab subfamily of small GTPases 55288 Rho (Ras homology) subfamily of Ras-like small GTPases 55293 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 55296 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 55311 leucine rich region 55320 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 55323 Domain in the RNA-binding Lupus La protein 55326 Phosphate acyltransferases 55327 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 55333 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 55342 Double-stranded RNA binding motif 55342 domain in DSRM or ZnF_C2H2 domain containing proteins 55351 Serine/Threonine protein kinases, catalytic domain 55359 Tyrosine kinase, catalytic domain 55364 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 55423 Immunoglobulin C-Type 55423 Immunoglobulin V-Type 55423 Immunoglobulin V-Type 55437 Serine/Threonine protein kinases, catalytic domain 55502 Orange domain 55506 Histone 2A 55506 Appr-1"-p processing enzyme 55509 basic region leucin zipper 55521 B-Box C-terminal domain 55521 Fibronectin type 3 domain 55521 Domain in SPla and the RYanodine Receptor. 55544 RNA recognition motif 55554 Trypsin-like serine protease 55554 Trypsin-like serine protease 55554 Trypsin-like serine protease 55554 Trypsin-like serine protease 55558 semaphorin domain 55558 ig-like, plexins, transcription factors 55558 GTPase-activator protein for Ras-like GTPases 55558 domain found in Plexins, Semaphorins and Integrins 55566 c4 zinc finger in nuclear hormone receptors 55568 Ricin-type beta-trefoil 55576 Link (Hyaluronan-binding) 55576 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 55582 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 55582 DNA Topoisomerase I (eukaryota) 55589 Serine/Threonine protein kinases, catalytic domain 55596 Basic domain in HLH proteins of MYOD family 55600 Fibrinogen-related domains (FReDs) 55605 WD40 repeats 55605 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 55612 Band 4.1 homologues 55612 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55613 Protein tyrosine phosphatase, catalytic domain motif 55616 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55620 Src homology 2 domains 55621 zinc finger 55632 Domain Homologous to E6-AP Carboxyl Terminus with 55634 krueppel associated box 55635 Domain found in Dishevelled, Egl-10, and Pleckstrin 55636 DEAD-like helicases superfamily 55636 Chromatin organization modifier domain 55636 helicase superfamily c-terminal domain 55659 krueppel associated box 55660 Contains two conserved F residues 55663 leucine rich region 55663 krueppel associated box 55666 Zinc finger domain 55673 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 55681 Tyrosine kinase, catalytic domain 55681 Serine/Threonine protein kinases, catalytic domain 55691 Band 4.1 homologues 55696 zinc finger 55696 RNA recognition motif 55698 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 55701 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55713 krueppel associated box 55715 Phosphotyrosine-binding domain (IRS1-like) 55715 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55727 Broad-Complex, Tramtrack and Bric a brac 55758 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 55766 Histone 2A 55766 Histone 2A 55768 domain present in PNGases and other hypothetical proteins 55768 domain in protein kinases, N-glycanases and other nuclear proteins 55773 Rhodanese Homology Domain 55773 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 55784 Protein kinase C conserved region 2 (CalB) 55789 GTPase-activator protein for Rho-like GTPases 55789 Domain found in Dishevelled, Egl-10, and Pleckstrin 55796 zinc finger 55799 von Willebrand factor (vWF) type A domain 55800 Immunoglobulin V-Type 55803 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55809 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 55809 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 55809 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 55810 FORKHEAD 55811 Adenylyl- / guanylyl cyclase, catalytic domain 55816 Phosphotyrosine-binding domain (IRS1-like) 55816 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55816 Phosphotyrosine-binding domain (IRS1-like) 55823 Ring finger 55827 WD40 repeats 55843 GTPase-activator protein for Rho-like GTPases 55843 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 55847 CDGSH-type zinc finger. Function unknown 55860 Actin 55870 bromo domain 55884 WD40 repeats 55884 suppressors of cytokine signalling 55888 leucine rich region 55900 krueppel associated box 55900 krueppel associated box 55901 Thrombospondin type 1 repeats 55909 BAR domain 55914 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 55925 Protein kinase C conserved region 2 (CalB) 55927 Orange domain 55930 Myosin. Large ATPases. ATPase 55935 Domain with 2 conserved Trp (W) residues 55943 Helical region found in SNAREs 55958 Kelch domain 55968 Domain of unknown function present in FAF1 (Fas-associated factor 1) 55968 Domain of unknown function present in FAF1 (Fas-associated factor 1) 55968 Domain of unknown function present in FAF1 (Fas-associated factor 1) 55970 G protein gamma subunit-like motifs 55971 Src homology 3 domains 55982 breast cancer carboxy-terminal domain 55983 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 55984 Serine/Threonine protein kinases, catalytic domain 55985 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 55987 Zn_pept domain 55992 Ring finger 55992 B-Box-type zinc finger 55992 B-Box C-terminal domain 55992 Filamin-type immunoglobulin domains 55992 B-Box-type zinc finger 55992 B-Box C-terminal domain 55992 Filamin-type immunoglobulin domains 56009 RNA recognition motif 56018 in StAR and phosphatidylcholine transfer protein 56031 RNA recognition motif 56034 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 56034 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 56036 domain present in cyclins, TFIIB and Retinoblastoma 56036 domain present in cyclins, TFIIB and Retinoblastoma 56044 Ras subfamily of RAS small GTPases 56048 Galectin 56053 leucine rich region 56053 krueppel associated box 56061 Ubiquitin homologues 56062 Kelch domain 56062 Kelch domain 56064 Immunoglobulin 56064 Immunoglobulin C-2 Type 56070 Domain with 2 conserved Trp (W) residues 56072 Galectin 56079 membrane-attack complex / perforin 56084 Protein present in Fab1, YOTB, Vac1, and EEA1 56085 Ubiquitin associated domain 56085 Ubiquitin associated domain 56092 Papain family cysteine protease 56093 membrane-attack complex / perforin 56094 Papain family cysteine protease 56097 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56097 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56098 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56098 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56099 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56099 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56100 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56100 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56101 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56101 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56102 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56102 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56103 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56103 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56104 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56104 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56105 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56105 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56105 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56106 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56106 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56107 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56107 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56108 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56108 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56109 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56109 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56110 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56110 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56111 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56111 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56112 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56112 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56113 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56113 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56114 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56114 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56121 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56122 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56123 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56124 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56125 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56126 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56127 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56128 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56129 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56130 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56131 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56132 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56133 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56134 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56134 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56135 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56135 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56136 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56136 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56137 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56137 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56137 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56138 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56138 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56139 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56139 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56139 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56140 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56140 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56141 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56141 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56142 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56142 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56142 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56143 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56143 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56143 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56143 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56144 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56144 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56145 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56145 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56146 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56146 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56146 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56147 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56147 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56147 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 56149 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56177 Olfactomedin-like domains 56193 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 56194 Contains two conserved F residues 56195 RNA recognition motif 56198 Orange domain 56212 Rho (Ras homology) subfamily of Ras-like small GTPases 56213 Insulin growth factor-binding protein homologues 56215 RNA recognition motif 56215 RNA recognition motif 56217 Src homology 3 domains 56217 domain in receptor targeting proteins Lin-2 and Lin-7 56217 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56217 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 56218 Broad-Complex, Tramtrack and Bric a brac 56221 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 56229 Thrombospondin type 1 repeats 56241 Somatomedin B -like domains 56241 von Willebrand factor (vWF) type D domain 56241 Domain abundant in complement control proteins 56241 Adhesion-associated domain present in MUC4 and other proteins 56242 krueppel associated box 56244 Immunoglobulin 56244 Immunoglobulin V-Type 56253 Immunoglobulin 56254 Ring finger 56258 RNA recognition motif 56264 Zn_pept domain 56265 Zn_pept domain 56267 RNA recognition motif 56274 Serine/Threonine protein kinases, catalytic domain 56275 RNA recognition motif 56275 RNA recognition motif 56288 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56291 Dual specificity phosphatase, catalytic domain 56294 Protein tyrosine phosphatase, catalytic domain 56296 Doublesex DNA-binding motif 56299 Tetratricopeptide repeats 56299 Tetratricopeptide repeats 56300 Interleukin-1 homologues 56304 Immunoglobulin V-Type 56324 Src homology 3 domains 56347 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 56349 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 56353 Zinc finger domain 56354 Tetratricopeptide repeats 56363 Kazal type serine protease inhibitors 56368 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the t 56373 Zn_pept domain 56376 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56376 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 56376 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56376 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56381 RNA recognition motif 56393 RNA recognition motif 56401 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 56401 Prolyl 4-hydroxylase alpha subunit homologues 56401 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 56403 RNA recognition motif 56405 Dual specificity phosphatase, catalytic domain 56405 Protein tyrosine phosphatase, catalytic domain 56405 Dual specificity phosphatase, catalytic domain 56405 Protein tyrosine phosphatase, catalytic domain motif 56410 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 56417 Double-stranded RNA binding motif 56417 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 56419 Formin Homology 2 Domain 56420 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 56424 Modified RING finger domain 56437 Ras subfamily of RAS small GTPases 56444 Actin 56456 Actin 56458 FORKHEAD 56460 Armadillo/beta-catenin-like repeats 56463 Staphylococcal nuclease homologues 56464 Papain family cysteine protease 56468 Src homology 2 domains 56468 suppressors of cytokine signalling 56480 Serine/Threonine protein kinases, catalytic domain 56484 FORKHEAD 56489 Serine/Threonine protein kinases, catalytic domain 56501 erythroblast transformation specific domain 56504 Serine/Threonine protein kinases, catalytic domain 56508 Guanine nucleotide exchange factor for Ras-like GTPases 56508 Guanine nucleotide exchange factor for Ras-like small GTPases 56513 PB1 domain 56513 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56516 RNA recognition motif 56520 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 56524 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 56527 Serine/Threonine protein kinases, catalytic domain 56527 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56538 Trypsin-like serine protease 56542 Serine/Threonine protein kinases, catalytic domain 56613 Serine/Threonine protein kinases, catalytic domain 56620 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 56622 ADAM Cysteine-Rich Domain 56622 Homologues of snake disintegrins 56623 Inositol polyphosphate phosphatase, catalytic domain homologues 56626 DNA polymerase X family 56628 Immunoglobulin C-Type 56636 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 56637 Serine/Threonine protein kinases, catalytic domain 56640 Trypsin-like serine protease 56644 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 56649 Scavenger receptor Cys-rich 56649 Trypsin-like serine protease 56649 Low-density lipoprotein receptor domain class A 56658 associated with SPRY domains 56658 Domain in SPla and the RYanodine Receptor. 56658 associated with SPRY domains 56658 Domain in SPla and the RYanodine Receptor. 56681 Sar1p-like members of the Ras-family of small GTPases 56697 Regulator of G protein signalling domain 56705 C-terminal to LisH motif. 56705 Lissencephaly type-1-like homology motif 56705 Domain in SPla and the RYanodine Receptor. 56707 krueppel associated box 56710 membrane-attack complex / perforin 56715 A20-like zinc fingers 56717 Phosphoinositide 3-kinase, catalytic domain 56717 Phosphoinositide 3-kinase, catalytic domain 56722 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins 56736 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 56741 Immunoglobulin 56741 Immunoglobulin C-2 Type 56741 Fibronectin type 3 domain 56741 Immunoglobulin 56741 Immunoglobulin C-2 Type 56741 Fibronectin type 3 domain 56741 Immunoglobulin 56741 Immunoglobulin C-2 Type 56741 Fibronectin type 3 domain 56747 Domain abundant in complement control proteins 56747 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 56758 zinc finger 56759 Pancreatic ribonuclease 56760 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 56761 Calcium-binding EGF-like domain 56761 Domain found in Notch and Lin-12 56763 RNA recognition motif 56767 Immunoglobulin 56767 Fibronectin type 3 domain 56767 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 56768 Protein kinase C conserved region 2 (CalB) 56768 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 56777 ADAM Cysteine-Rich Domain 56777 Homologues of snake disintegrins 56778 Ly-6 antigen / uPA receptor -like domain 56788 Calcium-binding EGF-like domain 56788 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 56792 Src homology 2 domains 56792 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 56806 ADAM Cysteine-Rich Domain 56806 Homologues of snake disintegrins 56808 von Willebrand factor (vWF) type A domain 56813 Domain present in hormone receptors 56817 Eps15 homology domain 56817 EF-hand, calcium binding motif 56822 Immunoglobulin V-Type 56826 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 56829 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 56829 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 56832 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 56835 Papain family cysteine protease 56853 RNA recognition motif 56868 Immunoglobulin 56868 Immunoglobulin C-2 Type 56869 krueppel associated box 56878 RNA recognition motif 56884 Immunoglobulin 56884 Kazal type serine protease inhibitors 56893 Ubiquitin associated domain 56894 Phosphate acyltransferases 56895 Phosphate acyltransferases 56899 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 56899 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 56904 BAR domain 56906 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 56910 in StAR and phosphatidylcholine transfer protein 56910 in StAR and phosphatidylcholine transfer protein 56914 Src homology 3 domains 56917 Homeodomain 56920 semaphorin domain 56920 domain found in Plexins, Semaphorins and Integrins 56924 Serine/Threonine protein kinases, catalytic domain 56938 PAS domain 56940 Dual specificity phosphatase, catalytic domain 56944 Olfactomedin-like domains 56950 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 56956 Homeodomain 56956 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 56957 A20-like zinc fingers 56959 DEAD-like helicases superfamily 56959 helicase superfamily c-terminal domain 56961 Src homology 2 domains 56979 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 56981 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 56983 Putative lipopolysaccharide-modifying enzyme 56983 Putative lipopolysaccharide-modifying enzyme 56992 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 56999 Thrombospondin type 1 repeats 56999 Thrombospondin type 1 repeats 56999 Thrombospondin type 1 repeats 57006 P21-Rho-binding domain 57018 domain present in cyclins, TFIIB and Retinoblastoma 57021 ADAM Cysteine-Rich Domain 57021 Homologues of snake disintegrins 57023 ADAM Cysteine-Rich Domain 57023 Homologues of snake disintegrins 57025 ADAM Cysteine-Rich Domain 57025 Homologues of snake disintegrins 57027 Homologues of snake disintegrins 57029 ADAM Cysteine-Rich Domain 57029 Homologues of snake disintegrins 57054 RNA recognition motif 57055 RNA recognition motif 57057 Domain first found in the mice T locus (Brachyury) protein 57057 Domain first found in the mice T locus (Brachyury) protein 57060 K homology RNA-binding domain 57060 K homology RNA-binding domain 57060 K homology RNA-binding domain 57060 K homology RNA-binding domain 57091 Src homology 3 domains 57093 Domain in SPla and the RYanodine Receptor. 57094 Zn_pept domain 57096 Protein kinase C conserved region 2 (CalB) 57097 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 57108 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 57109 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 57111 Rab subfamily of small GTPases 57115 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 57116 krueppel associated box 57116 krueppel associated box 57118 Serine/Threonine protein kinases, catalytic domain 57118 Serine/Threonine protein kinases, catalytic domain 57119 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 57119 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 57120 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57124 Calcium-binding EGF-like domain 57124 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 57125 domain found in Plexins, Semaphorins and Integrins 57135 RNA recognition motif 57139 Ras association (RalGDS/AF-6) domain 57139 Guanine nucleotide exchange factor for Ras-like GTPases 57139 Guanine nucleotide exchange factor for Ras-like small GTPases 57144 P21-Rho-binding domain 57144 Serine/Threonine protein kinases, catalytic domain 57144 P21-Rho-binding domain 57144 Serine/Threonine protein kinases, catalytic domain 57151 Alpha-lactalbumin / lysozyme C 57154 Domain with 2 conserved Trp (W) residues 57154 Protein kinase C conserved region 2 (CalB) 57154 Domain Homologous to E6-AP Carboxyl Terminus with 57159 Ring finger 57167 zinc finger 57172 Serine/Threonine protein kinases, catalytic domain 57180 Actin 57182 ankyrin repeats 57188 Immunoglobulin 57188 Immunoglobulin C-2 Type 57188 Thrombospondin type 1 repeats 57209 krueppel associated box 57209 krueppel associated box 57213 Domain in SPla and the RYanodine Receptor. 57215 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 57221 Sec7 domain 57231 Domain associated with PX domains 57231 Regulator of G protein signalling domain 57231 Domain associated with PX domains 57231 Regulator of G protein signalling domain 57232 krueppel associated box 57233 Homeodomain 57246 Domain first found in the mice T locus (Brachyury) protein 57256 Trypsin-like serine protease 57257 Src homology 2 domains 57257 Src homology 3 domains 57257 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 57257 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 57257 Src homology 2 domains 57257 Src homology 3 domains 57261 bromo domain 57265 Frizzled 57276 Immunoglobulin 57276 Immunoglobulin V-Type 57278 Immunoglobulin 57278 Immunoglobulin C-2 Type 57315 WD40 repeats 57315 WD40 repeats 57329 Src homology 3 domains 57335 krueppel associated box 57336 leucine rich region 57336 krueppel associated box 57343 krueppel associated box 57381 Rho (Ras homology) subfamily of Ras-like small GTPases 57396 Serine/Threonine protein kinases, catalytic domain 57410 Serine/Threonine protein kinases, catalytic domain 57418 WD40 repeats 57440 Eps15 homology domain 57444 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 57449 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 57449 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 57449 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 57449 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 57452 Ricin-type beta-trefoil 57453 Immunoglobulin 57453 Immunoglobulin C-2 Type 57455 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 57460 Serine/threonine phosphatases, family 2C, catalytic domain 57463 Immunoglobulin 57463 Immunoglobulin C-2 Type 57465 domain in TBC and LysM domain containing proteins 57465 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 57466 RNA recognition motif 57466 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 57475 Band 4.1 homologues 57475 Domain in Myosin and Kinesin Tails 57475 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 57477 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57480 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 57480 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 57484 Ring finger 57488 Protein kinase C conserved region 2 (CalB) 57491 PAS domain 57493 Calcium-binding EGF-like domain 57497 Immunoglobulin 57497 Immunoglobulin C-2 Type 57497 Fibronectin type 3 domain 57504 Bromo adjacent homology domain 57504 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 57514 GTPase-activator protein for Rho-like GTPases 57516 ATPases associated with a variety of cellular activities 57519 in StAR and phosphatidylcholine transfer protein 57520 Domain with 2 conserved Trp (W) residues 57520 Protein kinase C conserved region 2 (CalB) 57520 Domain Homologous to E6-AP Carboxyl Terminus with 57522 Src homology 3 domains 57522 Fes/CIP4 homology domain 57522 GTPase-activator protein for Rho-like GTPases 57524 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 57526 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 57528 Broad-Complex, Tramtrack and Bric a brac 57531 Domain Homologous to E6-AP Carboxyl Terminus with 57531 ankyrin repeats 57531 Domain Homologous to E6-AP Carboxyl Terminus with 57533 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 57534 ankyrin repeats 57534 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 57537 VPS10 domain 57538 Immunoglobulin 57541 krueppel associated box 57542 Kelch domain 57546 Serine/threonine phosphatases, family 2C, catalytic domain 57549 Immunoglobulin 57549 Immunoglobulin C-2 Type 57551 Tyrosine kinase, catalytic domain 57551 Serine/Threonine protein kinases, catalytic domain 57553 Calponin homology domain 57553 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 57554 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57556 semaphorin domain 57556 domain found in Plexins, Semaphorins and Integrins 57560 WD40 repeats 57563 Kelch domain 57565 Kelch domain 57565 Broad-Complex, Tramtrack and Bric a brac 57568 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57569 GTPase-activator protein for Rho-like GTPases 57573 krueppel associated box 57573 krueppel associated box 57575 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 57575 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 57576 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 57580 Domain found in Dishevelled, Egl-10, and Pleckstrin 57580 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 57580 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57584 GTPase-activator protein for Rho-like GTPases 57584 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57584 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 57591 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 57591 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 57593 ig-like, plexins, transcription factors 57594 Homeodomain 57595 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57610 C-terminal to LisH motif. 57610 Domain in SPla and the RYanodine Receptor. 57611 Leucine rich repeat C-terminal domain 57615 krueppel associated box 57616 Homeodomain 57619 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57620 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 57622 Immunoglobulin 57622 Immunoglobulin C-2 Type 57622 Fibronectin type 3 domain 57622 Leucine rich repeat C-terminal domain 57626 Kelch domain 57626 Broad-Complex, Tramtrack and Bric a brac 57629 Domain in the Doublecortin (DCX) gene product 57630 Ring finger 57630 Src homology 3 domains 57630 Ring finger 57630 Src homology 3 domains 57631 Calponin homology domain 57633 Immunoglobulin 57634 domain in helicases and associated with SANT domains 57636 GTPase-activator protein for Rho-like GTPases 57636 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 57642 Fibronectin type 3 domain 57642 von Willebrand factor (vWF) type A domain 57642 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 57644 Myosin. Large ATPases. ATPase 57645 krueppel associated box 57645 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 57649 PHD zinc finger 57657 Cyclic nucleotide-monophosphate binding domain 57659 Broad-Complex, Tramtrack and Bric a brac 57661 Ring finger 57661 PHD zinc finger 57664 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 57671 ig-like, plexins, transcription factors 57671 domain found in Plexins, Semaphorins and Integrins 57674 Ring finger 57677 krueppel associated box 57679 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 57680 DEAD-like helicases superfamily 57680 Chromatin organization modifier domain 57680 helicase superfamily c-terminal domain 57680 domain in transcription and CHROMO domain helicases 57689 Immunoglobulin 57689 Immunoglobulin C-2 Type 57689 Leucine rich repeat C-terminal domain 57690 RNA recognition motif 57690 RNA recognition motif 57690 Ubiquitin associated domain 57693 krueppel associated box 57696 DEAD-like helicases superfamily 57697 DEAD-like helicases superfamily 57699 von Willebrand factor (vWF) type A domain 57703 Middle domain of eukaryotic initiation factor 4G (eIF4G) 57703 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 57705 WD40 repeats 57707 domain in TBC and LysM domain containing proteins 57708 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 57713 SAM / Pointed domain 57713 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 57713 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 57715 Immunoglobulin 57715 semaphorin domain 57715 domain found in Plexins, Semaphorins and Integrins 57716 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57716 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 57717 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 57722 Immunoglobulin 57722 Immunoglobulin C-2 Type 57729 Immunoglobulin 57729 Immunoglobulin C-2 Type 57729 Tyrosine kinase, catalytic domain 57729 Serine/Threonine protein kinases, catalytic domain 57731 Spectrin repeats 57731 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 57732 Protein present in Fab1, YOTB, Vac1, and EEA1 57740 Serine/Threonine protein kinases, catalytic domain 57745 krueppel associated box 57751 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 57756 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 57757 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 57758 Calcium-binding EGF-like domain 57758 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 57761 Serine/Threonine protein kinases, catalytic domain 57764 Netrin C-terminal Domain 57764 Laminin N-terminal domain (domain VI) 57765 Domain first found in the mice T locus (Brachyury) protein 57778 Formin Homology 2 Domain 57782 krueppel associated box 57782 krueppel associated box 57784 BAR domain 57786 krueppel associated box 57787 Serine/Threonine protein kinases, catalytic domain 57794 glycine rich nucleic binding domain 57795 membrane-attack complex / perforin 57799 Rab subfamily of small GTPases 57801 Orange domain 57810 Immunoglobulin 57810 Immunoglobulin C-2 Type 57815 ATPases associated with a variety of cellular activities 57818 Acid phosphatase homologues 57826 Ras subfamily of RAS small GTPases 57829 P or trefoil or TFF domain 57863 Immunoglobulin 57875 Fibrinogen-related domains (FReDs) 57876 Domain found in sea urchin sperm protein, enterokinase, agrin 57908 U1-like zinc finger 57914 Fibronectin type 3 domain 57915 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 57915 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 58155 RNA recognition motif 58178 VPS10 domain 58179 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 58180 zinc finger 58180 Broad-Complex, Tramtrack and Bric a brac 58181 Interleukin-10 family 58188 Immunoglobulin 58194 Src homology 3 domains 58203 Z-DNA-binding domain in adenosine deaminases. Helix-turn-helix-containing domain. Also known as Zab 58205 Immunoglobulin 58205 Immunoglobulin 58205 Immunoglobulin C-2 Type 58214 Cystatin-like domain 58217 Immunoglobulin V-Type 58220 PB1 domain 58220 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 58223 Zinc-dependent metalloprotease 58223 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 58231 Serine/Threonine protein kinases, catalytic domain 58234 Src homology 3 domains 58234 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 58235 Immunoglobulin V-Type 58235 Immunoglobulin C-2 Type 58244 Helical region found in SNAREs 58473 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 58480 Rho (Ras homology) subfamily of Ras-like small GTPases 58488 in StAR and phosphatidylcholine transfer protein 58490 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 58492 krueppel associated box 58494 Immunoglobulin 58494 Immunoglobulin C-2 Type 58500 krueppel associated box 58508 high mobility group 58508 "FY-rich" domain, C-terminal region 58508 "FY-rich" domain, N-terminal region 58508 high mobility group 58508 "FY-rich" domain, C-terminal region 58508 "FY-rich" domain, N-terminal region 58513 Eps15 homology domain 58517 RNA recognition motif 58517 domain in splicing factors 58518 Papain family cysteine protease 58522 Ring finger 58524 Doublesex DNA-binding motif 58530 Immunoglobulin 58538 Src homology 3 domains 58538 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 58538 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 58808 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 58809 Pancreatic ribonuclease 58826 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 58838 Src homology 2 domains 58840 Serine/Threonine protein kinases, catalytic domain 58844 Src homology 2 domains 58844 Ras association (RalGDS/AF-6) domain 58844 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 58850 Ligand binding domain of hormone receptors 58859 Calcium-binding EGF-like domain 58860 Homologues of snake disintegrins 58862 RNA recognition motif 58864 Serine/Threonine protein kinases, catalytic domain 58868 Frizzled 58868 Frizzled 58916 Immunoglobulin 58917 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 58918 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 58921 FORKHEAD 58935 Laminin G domain 58935 Calcium-binding EGF-like domain 58935 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 58936 Tyrosine kinase, catalytic domain 58936 Serine/Threonine protein kinases, catalytic domain 58940 Histone 2A 58946 Immunoglobulin 58946 Fibronectin type 3 domain 58947 Trypsin-like serine protease 58948 Src homology 3 domains 58948 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 58948 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 58959 Domain present in hormone receptors 58960 Serine/Threonine protein kinases, catalytic domain 58964 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 58967 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 58967 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 58968 Immunoglobulin V-Type 58968 Calcium-binding EGF-like domain 58968 Domain abundant in complement control proteins 58968 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 58975 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 58979 G protein gamma subunit-like motifs 58982 Link (Hyaluronan-binding) 58982 Calcium-binding EGF-like domain 58982 Domain abundant in complement control proteins 58982 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 58988 Serine/Threonine protein kinases, catalytic domain 58992 Fibronectin type 1 domain 58992 Fibronectin type 2 domain 58992 Trypsin-like serine protease 58998 Immunoglobulin 58998 Immunoglobulin 58998 Immunoglobulin 59003 C-terminal to LisH motif. 59003 Lissencephaly type-1-like homology motif 59004 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 59007 domain present in PNGases and other hypothetical proteins 59007 domain in protein kinases, N-glycanases and other nuclear proteins 59009 Ring finger 59009 Src homology 3 domains 59012 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at presen 59013 RNA recognition motif 59016 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 59020 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 59021 Rab subfamily of small GTPases 59029 JAB/MPN domain 59040 Rab subfamily of small GTPases 59041 Serine/Threonine protein kinases, catalytic domain 59045 in StAR and phosphatidylcholine transfer protein 59057 leucine rich region 59074 Helical region found in SNAREs 59075 Serine/Threonine protein kinases, catalytic domain 59076 Serine/Threonine protein kinases, catalytic domain 59077 Serine/Threonine protein kinases, catalytic domain 59079 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 59083 Cystatin-like domain 59090 Ubiquitin homologues 59092 K homology RNA-binding domain 59093 K homology RNA-binding domain 59105 Immunoglobulin 59106 Calcium-binding EGF-like domain 59107 Calcium-binding EGF-like domain 59109 Immunoglobulin 59109 Tyrosine kinase, catalytic domain 59112 helix loop helix domain 59114 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 59125 Serine/Threonine protein kinases, catalytic domain 59126 Serine/Threonine protein kinases, catalytic domain 59265 Serine/threonine phosphatases, family 2C, catalytic domain 59267 Protein kinase C conserved region 2 (CalB) 59277 Netrin C-terminal Domain 59277 Laminin N-terminal domain (domain VI) 59290 Immunoglobulin V-Type 59290 Immunoglobulin C-2 Type 59302 Transforming growth factor-beta (TGF-beta) family 59304 Transforming growth factor-beta (TGF-beta) family 59305 Immunoglobulin 59312 Src homology 3 domains 59313 Immunoglobulin 59318 Immunoglobulin 59318 Immunoglobulin C-2 Type 59322 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 59322 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 59322 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 59323 Tyrosine kinase, catalytic domain 59326 Guanine nucleotide exchange factor for Ras-like GTPases 59326 Guanine nucleotide exchange factor for Ras-like small GTPases 59329 Serine/Threonine protein kinases, catalytic domain 59335 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 59336 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 59338 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 59339 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 59348 krueppel associated box 59349 Kelch domain 59350 Low-density lipoprotein receptor domain class A 60312 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 60323 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 60325 SERine Proteinase INhibitors 60328 Serine/Threonine protein kinases, catalytic domain 60341 Serine/Threonine protein kinases, catalytic domain 60352 Serine/Threonine protein kinases, catalytic domain 60367 Immunoglobulin 60367 Immunoglobulin C-2 Type 60371 Baculoviral inhibition of apoptosis protein repeat 60377 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 60378 Ly-6 antigen / uPA receptor -like domain 60379 Fibrillar collagens C-terminal domain 60379 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 60391 Laminin G domain 60391 putative band 4.1 homologues' binding motif 60396 Serine/Threonine protein kinases, catalytic domain 60434 BH4 Bcl-2 homology region 4 60436 Homeodomain 60437 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 60442 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 60443 Epsin N-terminal homology (ENTH) domain 60447 PAS domain 60447 helix loop helix domain 60447 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 60450 Src homology 3 domains 60450 Tyrosine kinase, catalytic domain 60462 basic region leucin zipper 60465 Src homology 3 domains 60468 basic region leucin zipper 60484 Immunoglobulin V-Type 60484 Link (Hyaluronan-binding) 60485 Domain with 2 conserved Trp (W) residues 60506 Leucine rich repeat C-terminal domain 60509 Zn_pept domain 60533 Immunoglobulin 60562 Helical region found in SNAREs 60566 Protein kinase C conserved region 2 (CalB) 60567 Protein kinase C conserved region 2 (CalB) 60582 Interleukin-1 homologues 60584 leukemia inhibitory factor 60587 Rhodanese Homology Domain 60589 Tyrosine kinase, catalytic domain 60589 Serine/Threonine protein kinases, catalytic domain 60589 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 60594 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 60596 Adenylyl- / guanylyl cyclase, catalytic domain 60611 FORKHEAD 60629 Immunoglobulin 60629 Thrombospondin type 1 repeats 60629 Domain present in ZO-1 and Unc5-like netrin receptors 60629 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 60630 Immunoglobulin 60630 Thrombospondin type 1 repeats 60630 Domain present in ZO-1 and Unc5-like netrin receptors 60630 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 60664 Src homology 2 domains 60668 Src homology 3 domains 60676 LamG-like jellyroll fold domain 60676 Domain found in Notch and Lin-12 60676 LamG-like jellyroll fold domain 60676 Domain found in Notch and Lin-12 60677 RNA recognition motif 60680 RNA recognition motif 63036 Trypsin-like serine protease 63827 Immunoglobulin V-Type 63827 Domain abundant in complement control proteins 63827 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 63834 calpain_III domain 63834 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 63835 Immunoglobulin V-Type 63839 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 63840 PAS domain 63845 Kazal type serine protease inhibitors 63849 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 63851 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 63856 Bromodomain transcription factors and PHD domain containing proteins 63879 Baculoviral inhibition of apoptosis protein repeat 63885 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 63893 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 63898 Src homology 2 domains 63906 glycine rich nucleic binding domain 63912 Calpain-like thiol protease family. 63917 Ricin-type beta-trefoil 63923 Fibronectin type 3 domain 63923 Fibrinogen-related domains (FReDs) 63924 Domains present in proteins implicated in post-mortem DNA fragmentation 63946 Doublesex DNA-binding motif 63948 Doublesex DNA-binding motif 63951 Doublesex DNA-binding motif 63953 Rhodanese Homology Domain 63971 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 63973 helix loop helix domain 63976 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 63978 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 63994 BAR domain 63994 GTPase-activator protein for Rho-like GTPases 63995 Rhodanese Homology Domain 64005 Myosin. Large ATPases. ATPase 64009 Spectrin repeats 64011 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 64014 Dual specificity phosphatase, catalytic domain 64023 Trypsin-like serine protease 64023 Domain abundant in complement control proteins 64023 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 64026 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 64027 associated with SPRY domains 64027 Domain in SPla and the RYanodine Receptor. 64030 Immunoglobulin 64030 Immunoglobulin C-2 Type 64030 Tyrosine kinase, catalytic domain 64032 von Willebrand factor (vWF) type C domain 64032 C-terminal cystine knot-like domain (CTCK) 64032 Insulin growth factor-binding protein homologues 64036 Domain abundant in complement control proteins 64036 Domain abundant in complement control proteins 64039 A Receptor for Ubiquitination Targets 64041 Baculoviral inhibition of apoptosis protein repeat 64044 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 64053 Src homology 3 domains 64053 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64053 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 64057 Immunoglobulin 64057 Immunoglobulin V-Type 64057 Link (Hyaluronan-binding) 64062 zinc finger 64062 RNA recognition motif 64063 Trypsin-like serine protease 64066 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 64067 PAS domain 64067 helix loop helix domain 64072 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64072 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64074 Kazal type serine protease inhibitors 64075 Kazal type serine protease inhibitors 64084 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64085 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64092 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 64093 Kazal type serine protease inhibitors 64094 Kazal type serine protease inhibitors 64100 Fibronectin type 2 domain 64101 Immunoglobulin 64124 Calcium-binding EGF-like domain 64124 G-protein-coupled receptor proteolytic site domain 64130 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64139 Papain family cysteine protease 64143 Ras subfamily of RAS small GTPases 64159 Spectrin repeats 64161 Phosphoinositide 3-kinase, catalytic domain 64175 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 64184 Pancreatic ribonuclease 64186 helix loop helix domain 64196 RNA recognition motif 64199 G protein gamma subunit-like motifs 64200 RNA recognition motif 64200 RNA recognition motif 64204 Plectin repeat 64209 Ubiquitin homologues 64214 Regulator of G protein signalling domain 64218 domain found in Plexins, Semaphorins and Integrins 64224 Ubiquitin homologues 64236 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64236 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64236 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 64293 Serine/Threonine protein kinases, catalytic domain 64293 Tyrosine kinase, catalytic domain 64293 erine/Threonine protein kinases, catalytic domain 64293 Serine/Threonine protein kinases, catalytic domain 64295 Ubiquitin homologues 64301 Tudor domain 64303 Profilin 64310 ARF-like small GTPases 64314 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 64316 Domain abundant in complement control proteins 64320 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 64324 domain with conserved PWWP motif 64324 domain with conserved PWWP motif 64326 Ring finger 64333 GTPase-activator protein for Rho-like GTPases 64333 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 64337 G protein gamma subunit-like motifs 64340 DEAD-like helicases superfamily 64340 helicase superfamily c-terminal domain 64344 PAS domain 64344 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 64344 PAS domain 64344 helix loop helix domain 64344 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 64344 PAS domain 64344 helix loop helix domain 64344 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 64344 PAS domain 64344 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 64345 PAS domain 64345 helix loop helix domain 64345 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 64350 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 64353 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64353 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 64356 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 64373 Rho (Ras homology) subfamily of Ras-like small GTPases 64379 Homeodomain 64386 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 64386 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 64391 Serine/Threonine protein kinases, catalytic domain 64393 U1-like zinc finger 64393 U1-like zinc finger 64394 U1-like zinc finger 64398 Src homology 3 domains 64398 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64398 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 64400 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 64403 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64403 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64405 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64407 Regulator of G protein signalling domain 64409 Ricin-type beta-trefoil 64411 GTPase-activator protein for Rho-like GTPases 64411 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 64411 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 64431 Actin 64434 Middle domain of eukaryotic initiation factor 4G (eIF4G) 64434 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 64435 Immunoglobulin V-Type 64436 Inositol polyphosphate phosphatase, catalytic domain homologues 64444 Homeodomain 64455 Rab subfamily of small GTPases 64455 Ras subfamily of RAS small GTPases 64455 Rho (Ras homology) subfamily of Ras-like small GTPases 64455 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 64459 Trypsin-like serine protease 64459 Domain abundant in complement control proteins 64459 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 64465 Rho (Ras homology) subfamily of Ras-like small GTPases 64471 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 64474 K homology RNA-binding domain 64474 K homology RNA-binding domain 64475 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 64478 Domain abundant in complement control proteins 64478 Domain abundant in complement control proteins 64478 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 64499 Trypsin-like serine protease 64506 RNA recognition motif 64510 RNA recognition motif 64510 glycine rich nucleic binding domain 64512 Frizzled 64520 Bromo adjacent homology domain 64520 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 64520 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 64525 Found in Skp1 protein family 64531 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64536 Insulin growth factor-binding protein homologues 64538 Serine/threonine phosphatases, family 2C, catalytic domain 64543 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 64546 Immunoglobulin C-2 Type 64549 Transforming growth factor-beta (TGF-beta) family 64550 DNA Topoisomerase I (eukaryota) 64552 membrane-attack complex / perforin 64553 Spectrin repeats 64556 RNA recognition motif 64557 breast cancer carboxy-terminal domain 64558 Frizzled 64560 Lysin motif 64563 Immunoglobulin 64565 Trypsin-like serine protease 64567 Leucine rich repeat N-terminal domain 64568 Galanin 64571 Homeodomain 64572 Homeodomain 64576 Fibronectin type 3 domain 64576 Protein tyrosine phosphatase, catalytic domain 64581 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 64600 Phospholipase A2 64622 Homeodomain 64627 Histone H4 64628 helix loop helix domain 64630 Helical region found in SNAREs 64635 Staphylococcal nuclease homologues 64641 helix loop helix domain 64646 Histone 2A 64647 Histone H2B 64652 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 64654 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 64666 Serine/Threonine protein kinases, catalytic domain 64680 Domain present in hormone receptors 64699 Trypsin-like serine protease 64699 Low-density lipoprotein receptor domain class A 64699 Trypsin-like serine protease 64699 Trypsin-like serine protease 64699 Trypsin-like serine protease 64699 Low-density lipoprotein receptor domain class A 64702 Ring finger 64702 associated with SPRY domains 64702 Domain in SPla and the RYanodine Receptor. 64706 Calcium-binding EGF-like domain 64706 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 64707 Chromatin organization modifier domain 64708 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 64754 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 64759 Src homology 2 domains 64759 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 64761 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 64778 Fibronectin type 3 domain 64782 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 64783 RNA recognition motif 64786 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 64787 Src homology 3 domains 64787 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 64790 Domain with 2 conserved Trp (W) residues 64798 Domain found in Dishevelled, Egl-10, and Pleckstrin 64798 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 64817 Calcium-binding EGF-like domain 64817 Domain abundant in complement control proteins 64817 Pentraxin / C-reactive protein / pentaxin family 64826 FORKHEAD 64827 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 64829 Protein kinase C conserved region 2 (CalB) 64830 Protein kinase C conserved region 2 (CalB) 64838 Fibronectin type 3 domain 64843 Homeodomain 64852 U1-like zinc finger 64852 RNA recognition motif 64857 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 64857 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 64865 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64881 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 64926 GTPase-activator protein for Ras-like GTPases 64926 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 64929 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 65003 Ribosomal protein L11/L12 65003 Ribosomal protein L11/L12 65003 Ribosomal protein L11/L12 65020 leucine rich region 65020 krueppel associated box 65022 Somatomedin B -like domains 65022 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 65025 Protein kinase C conserved region 2 (CalB) 65027 Chromatin organization modifier domain 65034 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 65037 Immunoglobulin 65037 Tyrosine kinase, catalytic domain 65038 Src homology 2 domains 65038 Inositol polyphosphate phosphatase, catalytic domain homologues 65038 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 65045 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 65047 Laminin G domain 65048 Laminin G domain 65048 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 65052 Phosphoinositide 3-kinase, catalytic domain 65052 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 65053 Ras association (RalGDS/AF-6) domain 65059 Ras association (RalGDS/AF-6) domain 65059 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 65061 Serine/Threonine protein kinases, catalytic domain 65096 Olfactomedin-like domains 65096 Domain present in hormone receptors 65098 A20-like zinc fingers 65107 Low-density lipoprotein receptor domain class A 65107 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 65116 Domain containing Gla (gamma-carboxyglutamate) residues 65116 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 65125 Serine/Threonine protein kinases, catalytic domain 65144 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 65158 Rab subfamily of small GTPases 65161 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins 65164 Insulin growth factor-binding protein homologues 65179 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 65189 Serine/Threonine protein kinases, catalytic domain 65217 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 65218 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 65243 krueppel associated box 65248 Serine/Threonine protein kinases, catalytic domain 65251 krueppel associated box 65256 suppressors of cytokine signalling 65256 suppressors of cytokine signalling 65257 suppressors of cytokine signalling 65261 Myosin. Large ATPases. ATPase 65266 Serine/Threonine protein kinases, catalytic domain 65267 Serine/Threonine protein kinases, catalytic domain 65268 Serine/Threonine protein kinases, catalytic domain 65945 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 65945 Cadherin repeats 65956 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 65962 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 65962 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 65964 Tyrosine kinase, catalytic domain 65964 Tyrosine kinase, catalytic domain 65969 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 65969 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 65975 Serine/Threonine protein kinases, catalytic domain 65977 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 65979 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 65980 bromo domain 65981 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 65982 leucine rich region 65983 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 65997 Ras subfamily of RAS small GTPases 66005 Glyco_18 domain 66013 Src homology 3 domains 66013 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 66018 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 66018 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 66027 Spectrin repeats 66027 Domain with 2 conserved Trp (W) residues 66037 RNA recognition motif 66042 C-terminal cystine knot-like domain (CTCK) 66053 Modified RING finger domain 66053 Modified RING finger domain 66055 RNA recognition motif 66066 G protein gamma subunit-like motifs 66085 JAB/MPN domain 66094 snRNP Sm proteins 66094 snRNP Sm proteins 66179 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 66205 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 66289 Pentraxin / C-reactive protein / pentaxin family 66313 Domain with 2 conserved Trp (W) residues 66313 Protein kinase C conserved region 2 (CalB) 66313 Domain Homologous to E6-AP Carboxyl Terminus with 66329 Domain abundant in complement control proteins 66361 AN1-like Zinc finger 66369 Double-stranded RNA binding motif 66373 snRNP Sm proteins 66394 Modified RING finger domain 66397 Sar1p-like members of the Ras-family of small GTPases 66419 Ribosomal protein L11/L12 66473 Trypsin-like serine protease 66492 U1-like zinc finger 66505 bromo domain 66513 Serine/threonine phosphatases, family 2C, catalytic domain 66521 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 66525 catalytic domain of ctd-like phosphatases 66526 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 66530 Domain present in ubiquitin-regulatory proteins 66530 domain in protein kinases, N-glycanases and other nuclear proteins 66557 BPI/LBP/CETP C-terminal domain 66557 BPI/LBP/CETP N-terminal domain 66589 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 66592 prohibitin homologues 66597 Ring finger 66599 RNA recognition motif 66601 Immunoglobulin 66610 Src homology 3 domains 66616 Src homology 3 domains 66622 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 66622 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 66626 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins 66627 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 66645 RNA recognition motif 66652 Fibrillar collagens C-terminal domain 66667 A domain family that is part of the cupin metalloenzyme superfamily 66673 VPS10 domain 66674 Domain in SPla and the RYanodine Receptor. 66685 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 66686 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 66687 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 66689 Kelch domain 66696 Band 4.1 homologues 66698 RNA recognition motif 66701 Domain in SPla and the RYanodine Receptor. 66704 RNA recognition motif 66705 deoxyribonuclease I 66713 Actin 66720 Kelch domain 66725 Serine/Threonine protein kinases, catalytic domain 66784 Immunoglobulin V-Type 66784 Immunoglobulin C-2 Type 66790 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 66797 putative band 4.1 homologues' binding motif 66799 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 66808 krueppel associated box 66810 zinc finger 66810 RNA recognition motif 66816 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 66826 Phosphate acyltransferases 66854 Ring finger 66854 associated with SPRY domains 66864 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 66871 von Willebrand factor (vWF) type A domain 66878 RIO-like kinase 66894 Protein kinase C conserved region 2 (CalB) 66898 Src homology 3 domains 66901 Trypsin-like serine protease 66901 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 66922 Ras subfamily of RAS small GTPases 66923 high mobility group 66923 Bromo adjacent homology domain 66930 Fibronectin type 3 domain 66932 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 66938 Src homology 3 domains 66949 Ring finger 66983 U1-like zinc finger 66985 Ras association (RalGDS/AF-6) domain 66989 Broad-Complex, Tramtrack and Bric a brac 67006 CDGSH-type zinc finger. Function unknown 67010 RNA recognition motif 67016 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 67016 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 67016 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 67019 Actin 67039 domain in splicing factors 67057 Zinc finger domain 67071 Serine/Threonine protein kinases, catalytic domain 67071 Tyrosine kinase, catalytic domain 67071 Extension to Ser/Thr-type protein kinases 67071 erine/Threonine protein kinases, catalytic domain 67071 Serine/Threonine protein kinases, catalytic domain 67112 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 67118 Ring finger 67118 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 67121 Serine/Threonine protein kinases, catalytic domain 67123 Ubiquitin associated domain 67145 Tetratricopeptide repeats 67155 bromo domain 67197 RNA recognition motif 67220 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 67225 RNA recognition motif 67231 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 67231 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 67231 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 67235 leucine rich region 67249 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 67269 Zn_pept domain 67295 Rab subfamily of small GTPases 67296 Src homology 2 domains 67296 suppressors of cytokine signalling 67300 Clathrin heavy chain repeat homology 67315 Immunoglobulin C-2 Type 67328 Alpha-lactalbumin / lysozyme C 67334 Histone 2A 67338 Protein present in Fab1, YOTB, Vac1, and EEA1 67345 Domain Homologous to E6-AP Carboxyl Terminus with 67370 krueppel associated box 67370 krueppel associated box 67373 Trypsin-like serine protease 67373 Trypsin-like serine protease 67373 Trypsin-like serine protease 67374 Immunoglobulin 67374 Immunoglobulin C-2 Type 67382 bromo domain 67399 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 67410 Guanine nucleotide exchange factor for Ras-like GTPases 67418 RNA recognition motif 67425 Src homology 3 domains 67425 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 67444 Sigma factor PP2C-like phosphatases 67444 Serine/threonine phosphatases, family 2C, catalytic domain 67445 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 67448 domain found in Plexins, Semaphorins and Integrins 67451 Armadillo/beta-catenin-like repeats 67455 Kelch domain 67457 Band 4.1 homologues 67459 ATPases associated with a variety of cellular activities 67465 Ubiquitin homologues 67474 Helical region found in SNAREs 67492 AN1-like Zinc finger 67492 Ubiquitin homologues 67498 Broad-Complex, Tramtrack and Bric a brac 67500 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 67500 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 67525 Ring finger 67525 B-Box C-terminal domain 67525 associated with SPRY domains 67525 Domain in SPla and the RYanodine Receptor. 67525 Ring finger 67525 B-Box-type zinc finger 67525 B-Box C-terminal domain 67525 associated with SPRY domains 67525 Domain in SPla and the RYanodine Receptor. 67527 zinc finger 67533 Sterile alpha motif 67533 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 67537 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 67552 Histone 2A 67552 Appr-1"-p processing enzyme 67557 Domain in the RNA-binding Lupus La protein 67561 WD40 repeats 67562 Immunoglobulin 67562 Immunoglobulin C-2 Type 67573 Scavenger receptor Cys-rich 67579 RNA recognition motif 67581 Rhodanese Homology Domain 67581 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 67586 Domain of unknown function present in FAF1 (Fas-associated factor 1) 67588 Ring finger 67597 Extension to Ser/Thr-type protein kinases 67603 Rhodanese Homology Domain 67607 krueppel associated box 67653 Rho (Ras homology) subfamily of Ras-like small GTPases 67657 Rab subfamily of small GTPases 67664 Ring finger 67664 Modified RING finger domain 67666 Immunoglobulin 67666 Link (Hyaluronan-binding) 67666 Immunoglobulin 67666 Immunoglobulin V-Type 67666 Link (Hyaluronan-binding) 67673 Ubiquitin homologues 67690 Trypsin-like serine protease 67701 Four-disulfide core domains 67702 Ring finger 67703 Immunoglobulin 67703 Immunoglobulin 67703 Immunoglobulin C-2 Type 67709 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 67711 Ring finger 67727 Helical region found in SNAREs 67742 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 67772 helicase superfamily c-terminal domain 67772 domain in transcription and CHROMO domain helicases 67776 Vault protein Inter-alpha-Trypsin domain 67776 von Willebrand factor (vWF) type A domain 67781 domain in DSRM or ZnF_C2H2 domain containing proteins 67784 ig-like, plexins, transcription factors 67790 Rab subfamily of small GTPases 67790 ARF-like small GTPases 67790 Rab subfamily of small GTPases 67790 Ras subfamily of RAS small GTPases 67790 Rho (Ras homology) subfamily of Ras-like small GTPases 67790 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 67812 Domain present in ubiquitin-regulatory proteins 67826 Helical region found in SNAREs 67839 LGN motif, putative GEFs specific for G-alpha GTPases 67839 LGN motif, putative GEFs specific for G-alpha GTPases 67844 Rab subfamily of small GTPases 67848 DEAD-like helicases superfamily 67848 helicase superfamily c-terminal domain 67857 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 67865 Regulator of G protein signalling domain 67866 Four-disulfide core domains 67868 Trypsin-like serine protease 67889 RNA recognition motif 67903 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 67905 Serine/threonine phosphatases, family 2C, catalytic domain 67916 Acid phosphatase homologues 67923 Found in Skp1 protein family 67949 RNA recognition motif 67958 RNA recognition motif 67958 Suppressor-of-White-APricot splicing regulator 67958 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 67959 RRM_1 domain 67985 krueppel associated box 67996 RNA recognition motif 68018 in StAR and phosphatidylcholine transfer protein 68018 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 68031 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 68035 RNA recognition motif 68038 Glyco_18 domain 68048 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 68053 Domain of unknown function present in FAF1 (Fas-associated factor 1) 68092 RNA recognition motif 68094 Chromatin organization modifier domain 68099 BAR domain 68135 JAB/MPN domain 68231 Histone 2A 68262 Phosphate acyltransferases 68272 RNA recognition motif 68272 RNA recognition motif 68278 DEAD-like helicases superfamily 68278 helicase superfamily c-terminal domain 68280 RNA recognition motif 68280 Domain in the RNA-binding Lupus La protein 68304 Filamin-type immunoglobulin domains 68304 Putative lipopolysaccharide-modifying enzyme 68328 Rab subfamily of small GTPases 68348 SERine Proteinase INhibitors 68350 Ring finger 68365 Rab subfamily of small GTPases 68385 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 68401 Acid phosphatase homologues 68401 Acid phosphatase homologues 68423 ankyrin repeats 68441 ARF-like small GTPases 68441 Rab subfamily of small GTPases 68441 Ras subfamily of RAS small GTPases 68441 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 68449 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 68453 Ly-6 antigen / uPA receptor -like domain 68477 C-terminal to LisH motif. 68477 Lissencephaly type-1-like homology motif 68481 Immunoglobulin 68481 Immunoglobulin V-Type 68494 ankyrin repeats 68497 Domain Homologous to E6-AP Carboxyl Terminus with 68497 Filamin-type immunoglobulin domains 68497 Domain Homologous to E6-AP Carboxyl Terminus with 68501 Modified RING finger domain 68507 Sterile alpha motif 68507 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 68509 Laminin G domain 68509 Pentraxin / C-reactive protein / pentaxin family 68511 Domain in the Doublecortin (DCX) gene product 68520 Protein present in Fab1, YOTB, Vac1, and EEA1 68526 Domain found in Dishevelled, Egl-10, and Pleckstrin 68553 von Willebrand factor (vWF) type A domain 68553 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 68604 WD40 repeats 68606 Serine/threonine phosphatases, family 2C, catalytic domain 68606 Sigma factor PP2C-like phosphatases 68606 Serine/threonine phosphatases, family 2C, catalytic domain 68612 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 68652 Zinc finger domain 68652 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 68668 Trypsin-like serine protease 68701 ankyrin repeats 68708 Rab subfamily of small GTPases 68718 Ring finger 68718 Modified RING finger domain 68729 Ring finger 68729 B-Box-type zinc finger 68729 B-Box C-terminal domain 68729 meprin and TRAF homology 68743 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 68753 Immunoglobulin 68753 Immunoglobulin C-2 Type 68753 Fibronectin type 3 domain 68760 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 68760 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 68764 Cadherin repeats 68764 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 68792 Domain abundant in complement control proteins 68794 Filamin-type immunoglobulin domains 68797 Immunoglobulin 68802 Immunoglobulin 68802 Immunoglobulin C-2 Type 68810 Immunoglobulin 68810 Immunoglobulin C-2 Type 68815 Broad-Complex, Tramtrack and Bric a brac 68837 FORKHEAD 68837 Forkhead associated domain 68839 ankyrin repeats 68860 von Willebrand factor (vWF) type A domain 68867 Ring finger 68895 Rab subfamily of small GTPases 68895 Ras subfamily of RAS small GTPases 68895 Rho (Ras homology) subfamily of Ras-like small GTPases 68911 PHD zinc finger 68922 WD40 repeats 68939 Rab subfamily of small GTPases 68939 Ras subfamily of RAS small GTPases 68939 Rho (Ras homology) subfamily of Ras-like small GTPases 68943 Tyrosine kinase, catalytic domain 68943 erine/Threonine protein kinases, catalytic domain 68943 Serine/Threonine protein kinases, catalytic domain 68952 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 68961 Tyrosine kinase, catalytic domain 68961 erine/Threonine protein kinases, catalytic domain 68961 Serine/Threonine protein kinases, catalytic domain 68980 WD40 repeats 69009 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 69014 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 69020 krueppel associated box 69024 PhoX homologous domain, present in p47phox and p40phox 69024 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 69052 Src homology 2 domains 69052 suppressors of cytokine signalling 69077 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 69090 K homology RNA-binding domain 69097 B-Box-type zinc finger 69097 B-Box-type zinc finger 69109 domain present in cyclins, TFIIB and Retinoblastoma 69131 Serine/Threonine protein kinases, catalytic domain 69142 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 69144 RNA recognition motif 69149 Kelch domain 69149 Broad-Complex, Tramtrack and Bric a brac 69159 Ras subfamily of RAS small GTPases 69165 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 69183 Complement component C1q domain 69183 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 69188 PHD zinc finger 69188 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 69207 RNA recognition motif 69228 krueppel associated box 69228 zinc finger 69228 krueppel associated box 69239 Domain present in PSD-95, Dlg, and ZO-1/2 69239 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 69239 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 69256 leucine rich region 69256 leucine rich region 69256 leucine rich region 69257 erythroblast transformation specific domain 69259 Broad-Complex, Tramtrack and Bric a brac 69282 uanine nucleotide exchange factor for Ras-like GTPases 69282 Guanine nucleotide exchange factor for Ras-like GTPases 69286 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains 69286 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 69288 Rab subfamily of small GTPases 69288 Ras subfamily of RAS small GTPases 69288 Broad-Complex, Tramtrack and Bric a brac 69288 Rho (Ras homology) subfamily of Ras-like small GTPases 69294 Cystatin-like domain 69360 domain in helicases and associated with SANT domains 69362 Cystatin-like domain 69372 Rhodanese Homology Domain 69382 Histone H2B 69386 Histone H4 69389 Histone H2B 69408 RNA recognition motif 69444 Alpha-lactalbumin / lysozyme C 69481 Actin 69511 Trypsin-like serine protease 69519 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 69524 Immunoglobulin 69537 deoxyribonuclease I 69538 von Willebrand factor (vWF) type A domain 69538 von Willebrand factor (vWF) type A domain 69540 Trypsin-like serine protease 69562 Tyrosine kinase, catalytic domain 69562 erine/Threonine protein kinases, catalytic domain 69562 Serine/Threonine protein kinases, catalytic domain 69581 Rho (Ras homology) subfamily of Ras-like small GTPases 69587 Ring finger 69597 ATPases associated with a variety of cellular activities 69601 GTPase-activator protein for Ras-like GTPases 69632 Domain present in PSD-95, Dlg, and ZO-1/2 69632 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 69632 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 69635 Serine/Threonine protein kinases, catalytic domain 69675 Immunoglobulin 69675 Immunoglobulin C-2 Type 69675 von Willebrand factor (vWF) type C domain 69677 Interleukin-1 homologues 69681 Serine/Threonine protein kinases, catalytic domain 69716 ATPases associated with a variety of cellular activities 69726 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 69807 Ring finger 69807 B-Box-type zinc finger 69810 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 69814 Trypsin-like serine protease 69834 Rab subfamily of small GTPases 69837 Ring finger 69847 Serine/Threonine protein kinases, catalytic domain 69847 Tyrosine kinase, catalytic domain 69847 erine/Threonine protein kinases, catalytic domain 69847 Serine/Threonine protein kinases, catalytic domain 69860 eukaryotic translation initiation factor 1A 69865 RNA recognition motif 69876 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 69876 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 69891 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 69920 C2C2 Zinc finger 69920 RNA polymerase subunit 9 69922 Serine/Threonine protein kinases, catalytic domain 69923 Diacylglycerol kinase catalytic domain (presumed) 69930 krueppel associated box 69944 krueppel associated box 69993 Src homology 2 domains 69993 GTPase-activator protein for Rho-like GTPases 69993 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 69994 Ubiquitin associated domain 70044 U1-like zinc finger 70044 RNA recognition motif 70052 WD40 repeats 70052 Splicing Factor Motif, present in Prp18 and Pr04 70065 ankyrin repeats 70065 Ubiquitin homologues 70080 Immunoglobulin C-2 Type 70082 Lysin motif 70097 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 70097 Sterile alpha motif 70097 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 70192 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 70218 Kinesin motor, catalytic domain. ATPase 70218 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 70221 RNA recognition motif 70235 WD40 repeats 70248 RNA recognition motif 70296 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 70364 Fibronectin type 3 domain 70369 BAG domains, present in regulator of Hsp70 proteins 70370 Calcium-binding EGF-like domain 70370 Domain abundant in complement control proteins 70370 Calcium-binding EGF-like domain 70370 Domain abundant in complement control proteins 70381 Dysferlin domain, C-terminal region 70381 Dysferlin domain, N-terminal region 70381 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 70381 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 70381 Dysferlin domain, C-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 70381 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 70415 Serine/Threonine protein kinases, catalytic domain 70439 RNA recognition motif 70439 Zinc finger domain 70439 RNA recognition motif 70445 Calcium-binding EGF-like domain 70445 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 70450 Protein kinase C conserved region 2 (CalB) 70470 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 70472 bromo domain 70472 bromo domain 70472 ATPases associated with a variety of cellular activities 70479 PhoX homologous domain, present in p47phox and p40phox 70479 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 70497 BAR domain 70497 GTPase-activator protein for Rho-like GTPases 70520 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains 70520 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 70530 Immunoglobulin 70530 Immunoglobulin C-2 Type 70530 Fibronectin type 3 domain 70549 I/LWEQ domain 70549 I/LWEQ domain 70550 krueppel associated box 70550 Gelsolin homology domain 70551 Tetratricopeptide repeats 70559 Src homology 3 domains 70568 von Willebrand factor (vWF) type A domain 70568 Protein kinase C conserved region 2 (CalB) 70571 Contains two conserved F residues 70571 Domain with 2 conserved Trp (W) residues 70573 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 70574 Zn_pept domain 70584 P21-Rho-binding domain 70584 Serine/Threonine protein kinases, catalytic domain 70584 P21-Rho-binding domain 70584 Tyrosine kinase, catalytic domain 70584 erine/Threonine protein kinases, catalytic domain 70584 Serine/Threonine protein kinases, catalytic domain 70604 DnaJ molecular chaperone homology domain 70611 A Receptor for Ubiquitination Targets 70616 glycine rich nucleic binding domain 70620 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 70620 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 70625 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 70625 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 70650 Basic domain in HLH proteins of MYOD family 70661 Serine/Threonine protein kinases, catalytic domain 70673 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 70673 zinc finger 70673 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 70686 Rhodanese Homology Domain 70686 Rhodanese Homology Domain 70693 Immunoglobulin 70693 G-protein-coupled receptor proteolytic site domain 70719 Fes/CIP4 homology domain 70719 GTPase-activator protein for Rho-like GTPases 70719 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 70719 Fes/CIP4 homology domain 70719 GTPase-activator protein for Rho-like GTPases 70719 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 70726 Fibrinogen-related domains (FReDs) 70727 uanine nucleotide exchange factor for Ras-like GTPases 70727 Guanine nucleotide exchange factor for Ras-like GTPases 70727 Guanine nucleotide exchange factor for Ras-like small GTPases 70729 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 70762 Domain in the Doublecortin (DCX) gene product 70762 Serine/Threonine protein kinases, catalytic domain 70772 Broad-Complex, Tramtrack and Bric a brac 70779 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 70784 Rab subfamily of small GTPases 70784 Ras subfamily of RAS small GTPases 70784 Rho (Ras homology) subfamily of Ras-like small GTPases 70788 Kelch domain 70788 Broad-Complex, Tramtrack and Bric a brac 70797 ankyrin repeats 70802 domain with conserved PWWP motif 70809 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 70823 high mobility group 70823 high mobility group 70835 Trypsin-like serine protease 70853 Tudor domain 70873 Cyclic nucleotide-monophosphate binding domain 70882 Armadillo/beta-catenin-like repeats 70902 Phosphate acyltransferases 70902 EF-hand, calcium binding motif 70927 associated with SET domains 70927 Cysteine-rich motif following a subset of SET domains 70927 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 70928 associated with SPRY domains 70930 RNA recognition motif 70945 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 70965 Sec7 domain 70980 Ubiquitin homologues 70980 Ubiquitin associated domain 70981 ankyrin repeats 70993 Trypsin-like serine protease 71003 Trypsin-like serine protease 71037 Trypsin-like serine protease 71063 krueppel associated box 71066 heat shock factor 71074 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 71078 ADAM Cysteine-Rich Domain 71078 Homologues of snake disintegrins 71085 GTPase-activator protein for Rho-like GTPases 71091 Tyrosine kinase, catalytic domain 71091 erine/Threonine protein kinases, catalytic domain 71091 Serine/Threonine protein kinases, catalytic domain 71096 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 71096 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 71099 Serine/Threonine protein kinases, catalytic domain 71131 krueppel associated box 71131 krueppel associated box 71132 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 71132 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 71145 Scavenger receptor Cys-rich 71162 Guanine nucleotide exchange factor for Ras-like GTPases 71176 A Receptor for Ubiquitination Targets 71183 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 71206 Lissencephaly type-1-like homology motif 71228 Guanylate kinase homologues 71228 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 71241 Doublesex DNA-binding motif 71302 Src homology 3 domains 71302 GTPase-activator protein for Rho-like GTPases 71302 Src homology 3 domains 71302 GTPase-activator protein for Rho-like GTPases 71302 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 71306 Immunoglobulin 71306 Immunoglobulin 71306 Immunoglobulin C-2 Type 71310 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 71310 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 71310 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 71310 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 71323 Ras association (RalGDS/AF-6) domain 71330 Broad-Complex, Tramtrack and Bric a brac 71340 RIO-like kinase 71355 Fibrillar collagens C-terminal domain 71371 ARID (A/T-rich interaction domain) domain 71375 FORKHEAD 71382 ATPases associated with a variety of cellular activities 71393 Broad-Complex, Tramtrack and Bric a brac 71395 Scavenger receptor Cys-rich 71395 Scavenger receptor Cys-rich 71395 Scavenger receptor Cys-rich 71395 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 71395 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 71435 GTPase-activator protein for Rho-like GTPases 71435 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 71436 Leucine rich repeat N-terminal domain 71436 Leucine rich repeat C-terminal domain 71461 Immunoglobulin 71461 Immunoglobulin C-2 Type 71461 Tyrosine kinase, catalytic domain 71514 RNA recognition motif 71520 Src homology 2 domains 71520 Src homology 3 domains 71540 PhoX homologous domain, present in p47phox and p40phox 71540 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 71544 GTPase-activator protein for Rho-like GTPases 71544 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 71566 Immunoglobulin 71567 minichromosome maintenance proteins 71591 krueppel associated box 71592 krueppel associated box 71592 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 71592 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 71597 Homeodomain 71602 Src homology 3 domains 71602 Myosin. Large ATPases 71602 Myosin. Large ATPases. ATPase 71609 DEATH domain, found in proteins involved in cell death (apoptosis) 71609 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 71619 ARF-like small GTPases 71619 G protein alpha subunit 71619 Rab subfamily of small GTPases 71619 Ras subfamily of RAS small GTPases 71619 Sar1p-like members of the Ras-family of small GTPases 71619 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 71682 WD40 repeats 71685 Ricin-type beta-trefoil 71690 Insulin growth factor-binding protein homologues 71693 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 71704 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 71709 GTPase-activator protein for Rho-like GTPases 71709 GTPase-activator protein for Rho-like GTPases 71720 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 71722 high mobility group 71729 Regulator of G protein signalling domain 71729 LGN motif, putative GEFs specific for G-alpha GTPases 71729 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 71729 Regulator of G protein signalling domain 71729 LGN motif, putative GEFs specific for G-alpha GTPases 71729 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 71729 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 71732 Ring finger 71732 Clathrin heavy chain repeat homology 71733 Somatomedin B -like domains 71733 von Willebrand factor (vWF) type D domain 71733 Adhesion-associated domain present in MUC4 and other proteins 71738 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 71738 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 71740 Immunoglobulin 71740 Immunoglobulin C-2 Type 71742 Tyrosine kinase, catalytic domain 71742 erine/Threonine protein kinases, catalytic domain 71742 Serine/Threonine protein kinases, catalytic domain 71746 Guanine nucleotide exchange factor for Ras-like GTPases 71746 Guanine nucleotide exchange factor for Ras-like small GTPases 71752 WD40 repeats 71753 Trypsin-like serine protease 71753 Low-density lipoprotein receptor domain class A 71756 Leucine rich repeat C-terminal domain 71766 RNA recognition motif 71766 RNA recognition motif 71775 Transferrin 71778 Kelch domain 71778 Broad-Complex, Tramtrack and Bric a brac 71785 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 71785 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 71787 RNA recognition motif 71791 Zn_pept domain 71791 Zn_pept domain 71801 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 71801 Protein present in Fab1, YOTB, Vac1, and EEA1 71801 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 71810 Ran-binding domain 71816 Ring finger 71820 WD40 repeats 71820 WD40 repeats 71822 ankyrin repeats 71822 Src homology 3 domains 71824 GTPase-activator protein for Rho-like GTPases 71833 WD40 repeats 71877 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 71884 Glyco_18 domain 71887 Serine/threonine phosphatases, family 2C, catalytic domain 71887 Serine/threonine phosphatases, family 2C, catalytic domain 71889 Epsin N-terminal homology (ENTH) domain 71889 Epsin N-terminal homology (ENTH) domain 71893 Src homology 3 domains 71897 Ly-6 antigen / uPA receptor -like domain 71910 Acid phosphatase homologues 71922 Immunoglobulin 71922 Immunoglobulin C-2 Type 71943 Domain present in VPS-27, Hrs and STAM 71946 DNA/RNA non-specific endonuclease 71946 DNA/RNA non-specific endonuclease 71950 Homeodomain 71956 Domain in SPla and the RYanodine Receptor. 71972 BAR domain 71972 Src homology 3 domains 71972 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 71973 RNA recognition motif 71990 helicase superfamily c-terminal domain 72007 Fibronectin type 3 domain 72014 Broad-Complex, Tramtrack and Bric a brac 72023 Cytochrome b-561 / ferric reductase transmembrane domain 72023 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 72042 Actin depolymerisation factor/cofilin -like domains 72050 Filamin-type immunoglobulin domains 72050 Putative lipopolysaccharide-modifying enzyme 72053 Ubiquitin homologues 72058 Immunoglobulin 72065 Ras subfamily of RAS small GTPases 72074 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 72088 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 72114 BED zinc finger 72129 Src homology 3 domains 72135 PHD zinc finger 72137 WD40 repeats 72137 Sterile alpha motif 72137 Modified RING finger domain 72137 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 72139 krueppel associated box 72149 Serine/Threonine protein kinases, catalytic domain 72151 ATPases associated with a variety of cellular activities 72152 RNA recognition motif 72152 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 72154 krueppel associated box 72154 krueppel associated box 72162 DEAD-like helicases superfamily 72162 helicase superfamily c-terminal domain 72169 B-Box-type zinc finger 72169 B-Box-type zinc finger 72179 A Receptor for Ubiquitination Targets 72179 Leucine-rich repeat - CC (cysteine-containing) subfamily 72179 A Receptor for Ubiquitination Targets 72179 Leucine-rich repeat - CC (cysteine-containing) subfamily 72180 krueppel associated box 72184 Kelch domain 72184 Broad-Complex, Tramtrack and Bric a brac 72194 A Receptor for Ubiquitination Targets 72195 Bromodomain transcription factors and PHD domain containing proteins 72238 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 72238 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 72238 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 72242 Immunoglobulin C-2 Type 72281 Src homology 2 domains 72287 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 72290 snRNP Sm proteins 72296 Src homology 3 domains 72296 domain involved in Ras-like GTPase signaling 72318 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 72318 Sec7 domain 72318 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 72323 suppressors of cytokine signalling 72324 domain found in Plexins, Semaphorins and Integrins 72324 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 72325 Domain present in VPS9 72329 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 72330 Broad-Complex, Tramtrack and Bric a brac 72333 Immunoglobulin 72333 Immunoglobulin C-2 Type 72378 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 72378 Src homology 3 domains 72378 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 72378 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 72381 Ubiquitin homologues 72400 glycine rich nucleic binding domain 72431 Immunoglobulin 72431 Immunoglobulin C-2 Type 72432 Kazal type serine protease inhibitors 72433 Rab subfamily of small GTPases 72434 Ly-6 antigen / uPA receptor -like domain 72459 RNA recognition motif 72469 Phospholipase C, catalytic domain (part) 72469 Phospholipase C, catalytic domain (part) 72469 Protein kinase C conserved region 2 (CalB) 72475 Lissencephaly type-1-like homology motif 72486 Ring finger 72508 Serine/Threonine protein kinases, catalytic domain 72508 Tyrosine kinase, catalytic domain 72508 Extension to Ser/Thr-type protein kinases 72508 erine/Threonine protein kinases, catalytic domain 72508 Serine/Threonine protein kinases, catalytic domain 72515 WD40 repeats 72536 GTPase-activator protein for Rho-like GTPases 72569 Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc 72607 Ubiquitin associated domain 72615 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 72621 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 72634 K homology RNA-binding domain 72662 Large family of predicted nucleotide-binding domains 72667 leucine rich region 72685 DnaJ molecular chaperone homology domain 72709 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 72723 krueppel associated box 72726 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 72726 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 72739 leucine rich region 72739 krueppel associated box 72739 zinc finger 72739 leucine rich region 72739 krueppel associated box 72754 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 72778 DnaJ molecular chaperone homology domain 72780 Thrombospondin type 1 repeats 72789 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 72823 Domain present in PSD-95, Dlg, and ZO-1/2 72823 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 72828 Src homology 3 domains 72828 Src homology 3 domains 72828 Ubiquitin associated domain 72832 Calcium-binding EGF-like domain 72843 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 72844 Broad-Complex, Tramtrack and Bric a brac 72871 Profilin 72895 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 72895 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 72902 Kazal type serine protease inhibitors 72902 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 72927 Immunoglobulin 72927 Immunoglobulin C-2 Type 72949 domain present in cyclins, TFIIB and Retinoblastoma 72958 krueppel associated box 72960 DNA Topoisomerase I (eukaryota) 72981 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 72981 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 72993 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 73016 Kringle domain 73016 present in yeast cell wall integrity and stress response component proteins 73016 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 73062 ankyrin repeats 73086 Serine/Threonine protein kinases, catalytic domain 73086 Tyrosine kinase, catalytic domain 73086 Extension to Ser/Thr-type protein kinases 73086 erine/Threonine protein kinases, catalytic domain 73086 Serine/Threonine protein kinases, catalytic domain 73106 Trypsin-like serine protease 73149 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 73158 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 73159 Cadherin repeats 73167 GTPase-activator protein for Rho-like GTPases 73167 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 73173 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 73178 P21-Rho-binding domain 73178 WASP homology region 1 73178 Wiskott Aldrich syndrome homology region 2 73230 von Willebrand factor (vWF) type D domain 73246 Ras association (RalGDS/AF-6) domain 73250 Immunoglobulin 73250 Immunoglobulin C-2 Type 73336 Trypsin-like serine protease 73340 Pentraxin / C-reactive protein / pentaxin family 73341 Src homology 3 domains 73341 Calponin homology domain 73341 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 73341 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 73368 Fibronectin type 3 domain 73368 Thrombospondin N-terminal -like domains 73368 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 73379 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 73382 Trypsin-like serine protease 73389 high mobility group 73389 domain in Ataxins and HMG containing proteins 73389 domain in Ataxins and HMG containing proteins 73412 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 73412 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 73430 krueppel associated box 73447 WD40 repeats 73469 Ring finger 73481 Trypsin-like serine protease 73547 Protein tyrosine phosphatase, catalytic domain 73547 Dual specificity phosphatase, catalytic domain 73547 Protein tyrosine phosphatase, catalytic domain motif 73626 Trypsin-like serine protease 73626 Trypsin-like serine protease 73626 Trypsin-like serine protease 73647 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 73649 Cytochrome b-561 / ferric reductase transmembrane domain 73649 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 73674 WD40 repeats 73683 WD40 repeats 73690 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 73707 Tyrosine kinase, catalytic domain 73707 Adenylyl- / guanylyl cyclase, catalytic domain 73713 RNA recognition motif 73720 Cystatin-like domain 73732 Domain found in sea urchin sperm protein, enterokinase, agrin 73736 Large family of predicted nucleotide-binding domains 73754 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 73826 RNA recognition motif 73826 RNA recognition motif 73910 GTPase-activator protein for Rho-like GTPases 73910 GTPase-activator protein for Rho-like GTPases 73940 Immunoglobulin V-Type 73940 Link (Hyaluronan-binding) 73998 Domain Homologous to E6-AP Carboxyl Terminus with 74002 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 74007 ankyrin repeats 74007 Broad-Complex, Tramtrack and Bric a brac 74012 Ras subfamily of RAS small GTPases 74015 Fes/CIP4 homology domain 74018 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 74020 Protein kinase C conserved region 2 (CalB) 74030 Domain present in VPS9 74042 PHD zinc finger 74042 A domain family that is part of the cupin metalloenzyme superfamily 74042 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 74044 DEAD-like helicases superfamily 74044 helicase superfamily c-terminal domain 74053 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 74053 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 74055 Ras association (RalGDS/AF-6) domain 74055 Phospholipase C, catalytic domain (part) 74055 Phospholipase C, catalytic domain (part) 74055 Guanine nucleotide exchange factor for Ras-like small GTPases 74103 Src homology 3 domains 74103 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 74103 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 74105 Domain present in VPS-27, Hrs and STAM 74111 RNA recognition motif 74111 RNA recognition motif 74116 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 74117 Actin 74118 Chromatin organization modifier domain 74120 leucine rich region 74120 krueppel associated box 74123 FORKHEAD 74131 Src homology 3 domains 74131 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 74137 Serine/Threonine protein kinases, catalytic domain 74142 ATPases associated with a variety of cellular activities 74144 Immunoglobulin 74149 krueppel associated box 74156 in StAR and phosphatidylcholine transfer protein 74164 Putative single-stranded nucleic acids-binding domain 74178 Serine/Threonine protein kinases, catalytic domain 74180 von Willebrand factor (vWF) type D domain 74180 C-terminal cystine knot-like domain (CTCK) 74180 von Willebrand factor (vWF) type C domain 74180 C-terminal cystine knot-like domain (CTCK) 74180 von Willebrand factor (vWF) type D domain 74187 WD40 repeats 74194 Rho (Ras homology) subfamily of Ras-like small GTPases 74198 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 74199 von Willebrand factor (vWF) type A domain 74202 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 74206 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 74213 RNA recognition motif 74213 zinc finger 74213 RNA recognition motif 74213 RNA recognition motif 74215 Trypsin-like serine protease 74253 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 74255 C-terminal to LisH motif. 74255 Lissencephaly type-1-like homology motif 74270 Domain in ubiquitin-specific proteases 74270 Domain in ubiquitin-specific proteases 74270 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 74286 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 74286 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 74302 Protein tyrosine phosphatase, catalytic domain motif 74306 Trypsin-like serine protease 74315 Ring finger 74318 Homeodomain 74326 RNA recognition motif 74334 C-terminal to LisH motif. 74334 Domain in SPla and the RYanodine Receptor. 74347 domain in TBC and LysM domain containing proteins 74347 domain in TBC and LysM domain containing proteins 74352 krueppel associated box 74352 krueppel associated box 74354 Guanylate kinase homologues 74354 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 74365 Ring finger 74365 Modified RING finger domain 74383 Ubiquitin associated domain 74383 Ubiquitin associated domain 74400 krueppel associated box 74405 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 74411 Acid phosphatase homologues 74438 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 74443 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 74448 ARF-like small GTPases 74448 Rab subfamily of small GTPases 74448 Sar1p-like members of the Ras-family of small GTPases 74480 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 74481 basic region leucin zipper 74483 ankyrin repeats 74483 K homology RNA-binding domain 74488 Leucine rich repeat C-terminal domain 74488 Leucine-rich repeats, typical (most populated) subfamily 74493 ankyrin repeats 74493 Sterile alpha motif 74493 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 74498 Domain present in PSD-95, Dlg, and ZO-1/2 74513 Low-density lipoprotein receptor domain class A 74513 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 74533 Broad-Complex, Tramtrack and Bric a brac 74561 Homeodomain 74562 Protein kinase C conserved region 2 (CalB) 74563 uanine nucleotide exchange factor for Ras-like GTPases 74563 Guanine nucleotide exchange factor for Ras-like GTPases 74563 Guanine nucleotide exchange factor for Ras-like small GTPases 74569 Tetratricopeptide repeats 74570 leucine rich region 74581 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 74581 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 74646 suppressors of cytokine signalling 74646 Domain in SPla and the RYanodine Receptor. 74649 Zn_pept domain 74670 krueppel associated box 74694 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 74694 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 74729 N-terminal to some SET domains 74729 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 74732 Syntaxin N-terminal domain 74732 Helical region found in SNAREs 74734 Rab subfamily of small GTPases 74734 Ras subfamily of RAS small GTPases 74734 Rho (Ras homology) subfamily of Ras-like small GTPases 74734 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 74734 Rab subfamily of small GTPases 74734 Ras subfamily of RAS small GTPases 74734 Rho (Ras homology) subfamily of Ras-like small GTPases 74734 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 74735 B-Box-type zinc finger 74737 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 74761 Immunoglobulin V-Type 74762 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 74769 Phosphoinositide 3-kinase, catalytic domain 74769 PI3-kinase family, Ras-binding domain 74769 Phosphoinositide 3-kinase, catalytic domain 74769 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 74769 Phosphoinositide 3-kinase, region postulated to contain C2 domain 74901 Kelch domain 74901 Broad-Complex, Tramtrack and Bric a brac 74943 Domain abundant in complement control proteins 74943 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 74943 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 75002 Trypsin-like serine protease 75019 Pancreatic ribonuclease 75029 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 75030 WD40 repeats 75050 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 75079 Broad-Complex, Tramtrack and Bric a brac 75097 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 75099 Lysin motif 75137 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 75137 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 75141 Rab subfamily of small GTPases 75141 Ras subfamily of RAS small GTPases 75141 Rho (Ras homology) subfamily of Ras-like small GTPases 75141 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 75196 ankyrin repeats 75219 Dual specificity phosphatase, catalytic domain 75219 Protein tyrosine phosphatase, catalytic domain 75219 Dual specificity phosphatase, catalytic domain 75267 In Between Ring fingers 75271 Histone 2A 75291 Broad-Complex, Tramtrack and Bric a brac 75292 Serine/Threonine protein kinases, catalytic domain 75292 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 75292 Tyrosine kinase, catalytic domain 75292 Serine/Threonine protein kinases, catalytic domain 75292 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 75292 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 75305 ankyrin repeats 75320 ZnF_C4 abd HLH domain containing kinases domain 75339 Chromatin organization modifier domain 75388 RNA recognition motif 75388 RNA recognition motif 75404 GTPase-activator protein for Rho-like GTPases 75410 "FY-rich" domain, C-terminal region 75410 Cysteine-rich motif following a subset of SET domains 75410 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 75415 Src homology 3 domains 75415 Domain with 2 conserved Trp (W) residues 75415 GTPase-activator protein for Rho-like GTPases 75415 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 75424 krueppel associated box 75426 Immunoglobulin 75426 Insulin growth factor-binding protein homologues 75471 ARF-like small GTPases 75471 Rab subfamily of small GTPases 75471 Ras subfamily of RAS small GTPases 75471 Rho (Ras homology) subfamily of Ras-like small GTPases 75471 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 75516 Tetratricopeptide repeats 75526 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 75533 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 75560 domain in helicases and associated with SANT domains 75580 Broad-Complex, Tramtrack and Bric a brac 75590 Protein tyrosine phosphatase, catalytic domain 75590 Dual specificity phosphatase, catalytic domain 75590 Protein tyrosine phosphatase, catalytic domain motif 75605 ARID (A/T-rich interaction domain) domain 75605 PHD zinc finger 75605 ARID (A/T-rich interaction domain) domain 75605 Small domain found in the jumonji family of transcription factors 75605 A domain family that is part of the cupin metalloenzyme superfamily 75605 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 75613 von Willebrand factor (vWF) type A domain 75668 Ras subfamily of RAS small GTPases 75668 Rab subfamily of small GTPases 75668 Ras subfamily of RAS small GTPases 75668 Rho (Ras homology) subfamily of Ras-like small GTPases 75668 Rab subfamily of small GTPases 75668 Ras subfamily of RAS small GTPases 75668 Rho (Ras homology) subfamily of Ras-like small GTPases 75669 Serine/Threonine protein kinases, catalytic domain 75669 WD40 repeats 75669 Tyrosine kinase, catalytic domain 75669 Serine/Threonine protein kinases, catalytic domain 75710 RNA recognition motif 75710 RNA recognition motif 75718 von Willebrand factor (vWF) type A domain 75739 Src homology 3 domains 75739 Domain present in PSD-95, Dlg, and ZO-1/2 75739 domain in receptor targeting proteins Lin-2 and Lin-7 75739 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 75746 Histidine kinase-like ATPases 75767 Protein kinase C conserved region 2 (CalB) 75769 Acid phosphatase homologues 75785 Kelch domain 75792 WD40 repeats 75796 Chromatin organization modifier domain 75841 Ring finger 75841 Ring finger 75863 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 75985 Rab subfamily of small GTPases 75987 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 76073 Ring finger 76080 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 76089 Ras association (RalGDS/AF-6) domain 76089 Guanine nucleotide exchange factor for Ras-like small GTPases 76089 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 76108 Ras subfamily of RAS small GTPases 76117 GTPase-activator protein for Rho-like GTPases 76117 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 76123 LGN motif, putative GEFs specific for G-alpha GTPases 76135 Domain present in PSD-95, Dlg, and ZO-1/2 76135 Domain found in Dishevelled, Egl-10, and Pleckstrin 76135 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 76167 RNA recognition motif 76183 RNA recognition motif 76183 RNA recognition motif 76223 Zn_pept domain 76223 Zn_pept domain 76251 DEAD-like helicases superfamily 76251 helicase superfamily c-terminal domain 76281 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 76293 Fibrinogen-related domains (FReDs) 76303 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 76338 Rab subfamily of small GTPases 76338 ARF-like small GTPases 76338 Rab subfamily of small GTPases 76338 Ras subfamily of RAS small GTPases 76338 Rho (Ras homology) subfamily of Ras-like small GTPases 76338 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 76365 Domain first found in the mice T locus (Brachyury) protein 76373 krueppel associated box 76378 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 76425 C-terminal to LisH motif. 76425 Lissencephaly type-1-like homology motif 76453 Trypsin-like serine protease 76469 Fibronectin type 3 domain 76469 Domain in SPla and the RYanodine Receptor. 76477 Netrin C-terminal Domain 76477 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 76479 Tudor domain 76560 Trypsin-like serine protease 76561 PhoX homologous domain, present in p47phox and p40phox 76561 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 76572 RRM_1 domain 76572 RNA recognition motif 76577 UAS domain 76577 UAS domain 76589 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 76608 Domain Homologous to E6-AP Carboxyl Terminus with 76608 Domain Homologous to E6-AP Carboxyl Terminus with 76626 RNA recognition motif 76645 G-protein-coupled receptor proteolytic site domain 76645 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 76646 WD40 repeats 76658 Guanine nucleotide exchange factor for Ras-like GTPases 76703 Zn_pept domain 76742 Band 4.1 homologues 76742 Ras association (RalGDS/AF-6) domain 76742 Domain present in PSD-95, Dlg, and ZO-1/2 76742 PhoX homologous domain, present in p47phox and p40phox 76742 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 76742 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 76748 bromo domain 76763 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 76768 Alkaline phosphatase homologues 76788 Kelch domain 76793 Forkhead associated domain 76795 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 76795 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 76797 Immunoglobulin C-Type 76804 Tudor domain 76813 Armadillo/beta-catenin-like repeats 76829 Phosphotyrosine-binding domain (IRS1-like) 76829 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 76834 krueppel associated box 76834 krueppel associated box 76843 WD40 repeats 76846 S4 RNA-binding domain 76857 Broad-Complex, Tramtrack and Bric a brac 76866 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases 76877 ARF-like small GTPases 76877 Rab subfamily of small GTPases 76877 Ras subfamily of RAS small GTPases 76877 Rho (Ras homology) subfamily of Ras-like small GTPases 76877 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 76897 RNA recognition motif 76901 PHD zinc finger 76936 RNA recognition motif 76938 RRM_1 domain 76938 glycine rich nucleic binding domain 76948 Ring finger 76965 Leucine rich repeat C-terminal domain 76974 Transthyretin 76980 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 76999 Trypsin-like serine protease 77032 Rhodanese Homology Domain 77087 ankyrin repeats 77113 Kelch domain 77113 Kelch domain 77116 Protein tyrosine phosphatase, catalytic domain motif 77286 glycine rich nucleic binding domain 77286 Putative single-stranded nucleic acids-binding domain 77286 glycine rich nucleic binding domain 77286 Putative single-stranded nucleic acids-binding domain 77305 WD40 repeats 77318 ankyrin repeats 77397 Alpha-lactalbumin / lysozyme C 77407 ARF-like small GTPases 77407 Rab subfamily of small GTPases 77407 Ras subfamily of RAS small GTPases 77407 Sar1p-like members of the Ras-family of small GTPases 77407 Rho (Ras homology) subfamily of Ras-like small GTPases 77407 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 77411 RNA recognition motif 77411 RNA recognition motif 77480 ankyrin repeats 77485 Tudor domain 77485 Tyrosine kinase, catalytic domain 77485 erine/Threonine protein kinases, catalytic domain 77485 Serine/Threonine protein kinases, catalytic domain 77527 Guanine nucleotide exchange factor for Ras-like GTPases 77527 Cyclic nucleotide-monophosphate binding domain 77527 Guanine nucleotide exchange factor for Ras-like GTPases 77531 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 77569 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 77569 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 77579 Myosin. Large ATPases 77579 Myosin. Large ATPases. ATPase 77596 G-protein-coupled receptor proteolytic site domain 77605 Histone 2A 77613 Trypsin-like serine protease 77652 krueppel associated box 77669 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 77705 Cystatin-like domain 77727 Immunoglobulin 77739 Thrombospondin type 1 repeats 77754 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 77782 DNA polymerase A domain 77782 DEAD-like helicases superfamily 77794 Thrombospondin type 1 repeats 77799 Src homology 2 domains 77935 Protein present in Fab1, YOTB, Vac1, and EEA1 77976 Serine/Threonine protein kinases, catalytic domain 77980 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 77987 Domain of unknown function in Sec63p, Brr2p and other proteins 77998 Galectin 78081 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains 78081 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 78088 ankyrin repeats 78239 BPTI/Kunitz family of serine protease inhibitors 78239 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 78240 Cystatin-like domain 78241 basic region leucin zipper 78242 Kazal type serine protease inhibitors 78244 U1-like zinc finger 78249 G-protein-coupled receptor proteolytic site domain 78251 krueppel associated box 78253 Serine/Threonine protein kinases, catalytic domain 78253 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 78255 Guanine nucleotide exchange factor for Ras-like small GTPases 78267 Kelch domain 78284 basic region leucin zipper 78286 Calponin homology domain 78303 Histone H2B 78304 snRNP Sm proteins 78394 DEAD-like helicases superfamily 78394 helicase superfamily c-terminal domain 78405 Nerve growth factor (NGF or beta-NGF) 78416 Pancreatic ribonuclease 78455 DEAD-like helicases superfamily 78507 Domain in SPla and the RYanodine Receptor. 78509 Short conserved domain in transcriptional regulators 78514 Src homology 3 domains 78514 GTPase-activator protein for Rho-like GTPases 78514 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 78514 Src homology 3 domains 78514 GTPase-activator protein for Rho-like GTPases 78514 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 78558 Insulin growth factor-binding protein homologues 78560 Domain present in hormone receptors 78609 Cystatin-like domain 78618 Putative GTP-ase activating proteins for the small GTPase, ARF 78618 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 78619 leucine rich region 78619 leucine rich region 78651 snRNP Sm proteins 78656 bromo domain 78670 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 78688 Caspase recruitment domain 78709 Kazal type serine protease inhibitors 78748 Ras association (RalGDS/AF-6) domain 78748 Ras association (RalGDS/AF-6) domain 78751 zinc finger 78771 Protein kinase C conserved region 2 (CalB) 78781 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 78783 domain with conserved PWWP motif 78784 RNA recognition motif 78789 Immunoglobulin 78798 WD40 repeats 78803 In Between Ring fingers 78808 WD40 repeats 78816 Fes/CIP4 homology domain 78816 GTPase-activator protein for Rho-like GTPases 78816 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 78891 Serine/Threonine protein kinases, catalytic domain 78892 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 78908 Immunoglobulin 78908 Immunoglobulin V-Type 78910 suppressors of cytokine signalling 78911 Fibronectin type 3 domain 78913 Ring finger 78919 Fibronectin type 3 domain 78919 Fibronectin type 3 domain 78938 A Receptor for Ubiquitination Targets 78943 Serine/Threonine protein kinases, catalytic domain 78943 domain in protein kinases, N-glycanases and other nuclear proteins 78957 Src homology 3 domains 78957 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 78958 Immunoglobulin 78958 Immunoglobulin C-2 Type 78960 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 78962 PAS domain 78962 PAS domain 78966 Regulator of G protein signalling domain 78966 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 78966 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 78967 Immunoglobulin 78969 Tyrosine kinase, catalytic domain 78969 Serine/Threonine protein kinases, catalytic domain 78971 Baculoviral inhibition of apoptosis protein repeat 78972 krueppel associated box 78974 Homeodomain 78975 Serine/Threonine protein kinases, catalytic domain 78999 Immunoglobulin 79011 Serine/Threonine protein kinases, catalytic domain 79012 Serine/Threonine protein kinases, catalytic domain 79025 Fibronectin type 3 domain 79033 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 79038 Protein present in Fab1, YOTB, Vac1, and EEA1 79056 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 79057 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 79070 Filamin-type immunoglobulin domains 79070 Putative lipopolysaccharide-modifying enzyme 79088 krueppel associated box 79092 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 79092 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 79092 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 79113 Tyrosine kinase, catalytic domain 79114 Immunoglobulin 79114 Immunoglobulin C-2 Type 79114 Tyrosine kinase, catalytic domain 79117 ARF-like small GTPases 79119 ARF-like small GTPases 79120 ARF-like small GTPases 79121 ARF-like small GTPases 79126 Scavenger receptor Cys-rich 79126 Trypsin-like serine protease 79126 factor I membrane attack complex 79126 Low-density lipoprotein receptor domain class A 79148 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 79148 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 79149 leucine rich region 79166 Immunoglobulin 79171 RNA recognition motif 79184 JAB/MPN domain 79187 Fibronectin type 3 domain 79187 Domain in SPla and the RYanodine Receptor. 79191 Homeodomain 79192 Homeodomain 79196 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 79196 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 79201 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 79208 Ephrin receptor ligand binding domain 79209 Src homology 2 domains 79209 Src homology 3 domains 79209 Tyrosine kinase, catalytic domain 79210 Kazal type serine protease inhibitors 79214 Ricin-type beta-trefoil 79216 Transforming growth factor-beta (TGF-beta) family 79218 G protein gamma subunit-like motifs 79219 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 79220 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 79222 Adenylyl- / guanylyl cyclase, catalytic domain 79225 Orange domain 79230 krueppel associated box 79249 Src homology 3 domains 79252 ADAM Cysteine-Rich Domain 79252 Thrombospondin type 1 repeats 79253 Villin headpiece domain 79253 Gelsolin homology domain 79256 RNA recognition motif 79257 Regulator of G protein signalling domain 79263 Ring finger 79263 associated with SPRY domains 79263 Domain in SPla and the RYanodine Receptor. 79264 Band 4.1 homologues 79362 Orange domain 79365 Orange domain 79368 Immunoglobulin 79368 Immunoglobulin 79368 Immunoglobulin 79410 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 79412 Kringle domain 79412 present in yeast cell wall integrity and stress response component proteins 79412 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 79412 Kringle domain 79412 present in yeast cell wall integrity and stress response component proteins 79412 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 79412 Kringle domain 79412 present in yeast cell wall integrity and stress response component proteins 79412 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 79412 Kringle domain 79412 present in yeast cell wall integrity and stress response component proteins 79412 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 79413 BED zinc finger 79414 Immunoglobulin 79429 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 79429 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 79431 Orange domain 79434 Rab subfamily of small GTPases 79438 Leucine rich repeat C-terminal domain 79438 Leucine rich repeat N-terminal domain 79443 Protein present in Fab1, YOTB, Vac1, and EEA1 79444 Baculoviral inhibition of apoptosis protein repeat 79444 Baculoviral inhibition of apoptosis protein repeat 79558 GS motif 79559 Immunoglobulin 79574 Src homology 3 domains 79574 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 79574 Src homology 3 domains 79574 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 79574 Src homology 3 domains 79574 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 79618 Homeodomain 79623 Ricin-type beta-trefoil 79654 Domain Homologous to E6-AP Carboxyl Terminus with 79658 Src homology 3 domains 79658 GTPase-activator protein for Rho-like GTPases 79666 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 79674 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 79676 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 79695 Ricin-type beta-trefoil 79698 U1-like zinc finger 79701 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 79718 Lissencephaly type-1-like homology motif 79719 Rab subfamily of small GTPases 79723 Chromatin organization modifier domain 79726 WD40 repeats 79726 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 79735 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 79744 krueppel associated box 79752 AN1-like Zinc finger 79772 Protein kinase C conserved region 2 (CalB) 79774 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 79776 Homeodomain 79785 Ras subfamily of RAS small GTPases 79786 Kelch domain 79812 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 79827 Immunoglobulin 79830 zinc finger in transposases and transcription factors 79837 Phosphatidylinositol phosphate kinases 79841 Zn_pept domain 79849 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 79850 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 79858 Serine/Threonine protein kinases, catalytic domain 79869 RNA recognition motif 79875 Thrombospondin type 1 repeats 79890 Domain present in VPS9 79891 krueppel associated box 79898 krueppel associated box 79908 Immunoglobulin 79913 Actin 79917 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 79926 Immunoglobulin 79932 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 79932 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 79937 Laminin G domain 79952 Src homology 2 domains 79955 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 79981 Band 4.1 homologues 79990 Band 4.1 homologues 79990 Domain in Myosin and Kinesin Tails 80004 RNA recognition motif 80031 semaphorin domain 80031 domain found in Plexins, Semaphorins and Integrins 80031 semaphorin domain 80031 semaphorin domain 80031 domain found in Plexins, Semaphorins and Integrins 80031 semaphorin domain 80031 domain found in Plexins, Semaphorins and Integrins 80031 semaphorin domain 80031 domain found in Plexins, Semaphorins and Integrins 80031 semaphorin domain 80031 domain found in Plexins, Semaphorins and Integrins 80070 Thrombospondin type 1 repeats 80095 krueppel associated box 80115 Src homology 3 domains 80122 Serine/Threonine protein kinases, catalytic domain 80128 B-Box C-terminal domain 80128 Fibronectin type 3 domain 80144 Domains in Na-Ca exchangers and integrin-beta4 80174 breast cancer carboxy-terminal domain 80174 Zinc finger in DBF-like proteins 80174 breast cancer carboxy-terminal domain 80176 suppressors of cytokine signalling 80176 Domain in SPla and the RYanodine Receptor. 80179 Myosin. Large ATPases. ATPase 80204 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 80243 Domain found in Dishevelled, Egl-10, and Pleckstrin 80243 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 80243 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 80258 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 80263 B-Box C-terminal domain 80263 Filamin-type immunoglobulin domains 80264 krueppel associated box 80274 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 80283 Broad-Complex, Tramtrack and Bric a brac 80289 Lysin motif 80297 Spectrin repeats 80297 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 80301 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 80307 Protein kinase C conserved region 2 (CalB) 80307 Protein kinase C conserved region 2 (CalB) 80310 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 80310 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 80311 Kelch domain 80311 Broad-Complex, Tramtrack and Bric a brac 80315 RNA recognition motif 80315 RNA recognition motif 80317 leucine rich region 80317 krueppel associated box 80331 DnaJ molecular chaperone homology domain 80332 ADAM Cysteine-Rich Domain 80332 Homologues of snake disintegrins 80332 ADAM Cysteine-Rich Domain 80332 Homologues of snake disintegrins 80333 Eps15 homology domain 80333 EF-hand, calcium binding motif 80333 Eps15 homology domain 80333 EF-hand, calcium binding motif 80333 Eps15 homology domain 80333 EF-hand, calcium binding motif 80333 Eps15 homology domain 80333 EF-hand, calcium binding motif 80334 Eps15 homology domain 80334 EF-hand, calcium binding motif 80338 zinc finger in transposases and transcription factors 80341 BPI/LBP/CETP C-terminal domain 80341 BPI/LBP/CETP N-terminal domain 80343 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 80345 leucine rich region 80351 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 80352 associated with SPRY domains 80352 Domain in SPla and the RYanodine Receptor. 80352 associated with SPRY domains 80380 Immunoglobulin 80381 Immunoglobulin 80381 Immunoglobulin V-Type 80517 Ubiquitin homologues 80700 Domain present in ubiquitin-regulatory proteins 80700 domain in protein kinases, N-glycanases and other nuclear proteins 80707 Domain with 2 conserved Trp (W) residues 80708 Src homology 3 domains 80708 Fes/CIP4 homology domain 80708 Src homology 3 domains 80708 Fes/CIP4 homology domain 80712 Homeodomain 80714 Homeodomain 80719 Immunoglobulin V-Type 80728 Domain in Myosin and Kinesin Tails 80728 GTPase-activator protein for Rho-like GTPases 80744 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 80749 Immunoglobulin 80760 Vault protein Inter-alpha-Trypsin domain 80760 von Willebrand factor (vWF) type A domain 80764 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 80778 krueppel associated box 80782 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 80794 Ring finger 80796 Eps15 homology domain 80796 EF-hand, calcium binding motif 80797 von Willebrand factor (vWF) type A domain 80818 krueppel associated box 80824 Rhodanese Homology Domain 80824 Protein tyrosine phosphatase, catalytic domain 80824 Dual specificity phosphatase, catalytic domain 80824 Protein tyrosine phosphatase, catalytic domain motif 80837 Rho (Ras homology) subfamily of Ras-like small GTPases 80848 Calcium-binding EGF-like domain 80848 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 80852 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 80853 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 80861 DEAD-like helicases superfamily 80883 Laminin N-terminal domain (domain VI) 80883 Laminin-type epidermal growth factor-like domai 80890 Ring finger 80890 B-Box-type zinc finger 80890 B-Box C-terminal domain 80890 Filamin-type immunoglobulin domains 80890 Ring finger 80890 B-Box-type zinc finger 80890 B-Box C-terminal domain 80890 Filamin-type immunoglobulin domains 80891 Immunoglobulin 80891 Scavenger receptor Cys-rich 80891 Immunoglobulin 80891 Immunoglobulin C-2 Type 80891 Scavenger receptor Cys-rich 80893 Trypsin-like serine protease 80895 Serine/threonine phosphatases, family 2C, catalytic domain 80902 leucine rich region 80902 krueppel associated box 80904 Ring finger 80915 Dual specificity phosphatase, catalytic domain 80975 Trypsin-like serine protease 80987 Src homology 3 domains 81002 B-Box C-terminal domain 81003 Ring finger 81003 B-Box C-terminal domain 81003 Ring finger 81003 ARF-like small GTPases 81003 B-Box C-terminal domain 81003 G protein alpha subunit 81003 Rab subfamily of small GTPases 81003 Sar1p-like members of the Ras-family of small GTPases 81003 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 81004 Lissencephaly type-1-like homology motif 81005 Pentraxin / C-reactive protein / pentaxin family 81030 Z-DNA-binding domain in adenosine deaminases. Helix-turn-helix-containing domain. Also known as Zab 81033 Cyclic nucleotide-monophosphate binding domain 81035 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 81494 Domain abundant in complement control proteins 81504 Src homology 3 domains 81510 Src homology 3 domains 81514 Immunoglobulin 81515 Tyrosine kinase, catalytic domain 81523 Olfactomedin-like domains 81526 von Willebrand factor (vWF) type C domain 81526 C-terminal cystine knot-like domain (CTCK) 81526 Insulin growth factor-binding protein homologues 81527 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 81527 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 81531 Profilin 81536 Acid phosphatase homologues 81543 Leucine rich repeat N-terminal domain 81550 Tudor domain 81550 Ubiquitin associated domain 81559 Ring finger 81559 associated with SPRY domains 81569 Actin 81569 Actin 81600 Glyco_18 domain 81600 Chitin-binding domain type 2 81600 Glyco_18 domain 81600 Chitin-binding domain type 2 81601 Chromatin organization modifier domain 81603 Ring finger 81607 Immunoglobulin C-2 Type 81609 Band 4.1 homologues 81609 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 81613 Immunoglobulin 81613 Immunoglobulin C-2 Type 81621 Immunoglobulin 81621 Insulin growth factor-binding protein homologues 81624 Formin Homology 2 Domain 81629 Serine/Threonine protein kinases, catalytic domain 81630 zinc finger 81630 Broad-Complex, Tramtrack and Bric a brac 81635 Double-stranded RNA binding motif 81635 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 81639 Lipoxygenase homology 2 (beta barrel) domain 81647 basic region leucin zipper 81648 corticotropin-releasing factor 81649 Serine/Threonine protein kinases, catalytic domain 81651 Laminin G domain 81652 Glyco_18 domain 81659 DnaJ molecular chaperone homology domain 81659 Serine/Threonine protein kinases, catalytic domain 81667 WD40 repeats 81669 domain present in cyclins, TFIIB and Retinoblastoma 81678 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 81680 Fibronectin type 3 domain 81686 Fibronectin type 2 domain 81686 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 81687 Fibronectin type 2 domain 81687 Zinc-dependent metalloprotease 81687 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 81691 RNA recognition motif 81691 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 81703 basic region leucin zipper 81722 Immunoglobulin 81725 Immunoglobulin 81725 Immunoglobulin C-2 Type 81725 Tyrosine kinase, catalytic domain 81732 Actin 81733 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 81734 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 81735 Immunoglobulin 81735 Immunoglobulin C-2 Type 81735 Fibronectin type 3 domain 81741 Serine/Threonine protein kinases, catalytic domain 81743 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 81745 Serine/Threonine protein kinases, catalytic domain 81747 Phosphoinositide 3-kinase, catalytic domain 81749 Protein kinase C conserved region 2 (CalB) 81749 Serine/Threonine protein kinases, catalytic domain 81753 Domain present in hormone receptors 81756 Rab subfamily of small GTPases 81756 ARF-like small GTPases 81756 Rab subfamily of small GTPases 81756 Ras subfamily of RAS small GTPases 81756 Rho (Ras homology) subfamily of Ras-like small GTPases 81756 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 81757 Ras subfamily of RAS small GTPases 81760 Serine/Threonine protein kinases, catalytic domain 81762 Serine/Threonine protein kinases, catalytic domain 81762 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 81762 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 81771 Serine/Threonine protein kinases, catalytic domain 81779 Domain present in hormone receptors 81780 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 81781 snRNP Sm proteins 81783 Domain in the RNA-binding Lupus La protein 81785 high mobility group 81788 Serine/Threonine protein kinases, catalytic domain 81789 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 81792 Thrombospondin type 1 repeats 81794 Thrombospondin type 1 repeats 81806 SERine Proteinase INhibitors 81807 Ubiquitin homologues 81812 Ligand binding domain of hormone receptors 81821 Diacylglycerol kinase accessory domain (presumed) 81821 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 81825 RNA recognition motif 81830 Rab subfamily of small GTPases 81831 Low-density lipoprotein receptor domain class A 81831 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 81832 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 81832 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 81840 VPS10 domain 81844 Ring finger 81844 B-Box-type zinc finger 81844 Ring finger 81844 B-Box-type zinc finger 81845 glycine rich nucleic binding domain 81846 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 81847 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 81875 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 81877 Fibronectin type 3 domain 81877 Fibrinogen-related domains (FReDs) 81892 RNA recognition motif 81896 WD40 repeats 81918 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 81921 BAR domain 81921 Src homology 3 domains 81922 BAR domain 81922 Src homology 3 domains 81923 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 81928 domain present in cyclins, TFIIB and Retinoblastoma 83259 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83259 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83259 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83382 Immunoglobulin V-Type 83382 Immunoglobulin C-2 Type 83416 Immunoglobulin 83416 Immunoglobulin C-2 Type 83417 Immunoglobulin 83435 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 83436 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 83452 Rab subfamily of small GTPases 83465 Laminin G domain 83465 Calcium-binding EGF-like domain 83465 Domain present in hormone receptors 83465 Laminin-type epidermal growth factor-like domai 83465 G-protein-coupled receptor proteolytic site domain 83465 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83466 Laminin G domain 83466 Calcium-binding EGF-like domain 83466 Domain present in hormone receptors 83466 G-protein-coupled receptor proteolytic site domain 83466 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83467 Laminin G domain 83469 Low-density lipoprotein-receptor YWTD domain 83476 von Willebrand factor (vWF) type C domain 83476 Insulin growth factor-binding protein homologues 83478 GTPase-activator protein for Rho-like GTPases 83481 Plectin repeat 83486 RNA recognition motif 83486 glycine rich nucleic binding domain 83498 RNA recognition motif 83501 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83502 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83506 Serine/Threonine protein kinases, catalytic domain 83515 RNA recognition motif 83516 RNA recognition motif 83517 Fibrinogen-related domains (FReDs) 83521 Ras subfamily of RAS small GTPases 83526 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 83526 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 83527 Src homology 3 domains 83527 Actin depolymerisation factor/cofilin -like domains 83552 Frizzled 83552 Low-density lipoprotein receptor domain class A 83552 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 83554 Kazal type serine protease inhibitors 83560 Tyrosine kinase, catalytic domain 83570 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 83572 Lissencephaly type-1-like homology motif 83573 Tyrosine kinase, catalytic domain 83574 Ligand binding domain of hormone receptors 83574 c4 zinc finger in nuclear hormone receptors 83575 Zn_pept domain 83576 VPS10 domain 83577 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 83577 von Willebrand factor (vWF) type A domain 83577 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 83580 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 83584 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 83591 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 83593 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 83593 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 83593 Ras association (RalGDS/AF-6) domain 83593 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 83605 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 83616 Ring finger 83616 B-Box-type zinc finger 83616 B-Box C-terminal domain 83616 Filamin-type immunoglobulin domains 83617 Serine/Threonine protein kinases, catalytic domain 83619 basic region leucin zipper 83620 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 83620 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 83620 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 83627 Ricin-type beta-trefoil 83630 Paired Box domain 83631 Death effector domain 83660 I/LWEQ domain 83672 Protein kinase C conserved region 2 (CalB) 83675 K homology RNA-binding domain 83675 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 83681 Src homology 2 domains 83681 suppressors of cytokine signalling 83684 Leucine rich repeat C-terminal domain 83685 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 83690 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 83691 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 83694 Serine/Threonine protein kinases, catalytic domain 83700 Immunoglobulin 83706 Band 4.1 homologues 83706 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 83708 Immunoglobulin 83708 Fibronectin type 3 domain 83709 Putative GTP-ase activating proteins for the small GTPase, ARF 83709 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins 83711 Transforming growth factor-beta (TGF-beta) family 83716 LCCL domain 83716 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 83717 Leucine rich repeat N-terminal domain 83720 Laminin G domain 83720 Calcium-binding EGF-like domain 83720 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 83722 Serine/Threonine protein kinases, catalytic domain 83723 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 83724 PAS domain 83724 helix loop helix domain 83729 Transforming growth factor-beta (TGF-beta) family 83732 RIO-like kinase 83732 RIO-like kinase 83737 Protein kinase C conserved region 2 (CalB) 83744 krueppel associated box 83746 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 83759 RNA recognition motif 83762 Protein kinase C conserved region 2 (CalB) 83766 Actin 83785 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 83786 Band 4.1 homologues 83805 Tyrosine kinase, catalytic domain 83809 Domain of unknown function present in FAF1 (Fas-associated factor 1) 83813 Tyrosine kinase, catalytic domain 83823 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 83825 Serine/Threonine protein kinases, catalytic domain 83840 Serine/Threonine protein kinases, catalytic domain 83841 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 83850 Protein kinase C conserved region 2 (CalB) 83851 Protein kinase C conserved region 2 (CalB) 83851 Protein kinase C conserved region 2 (CalB) 83852 Methyl-CpG binding domain 83852 N-terminal to some SET domains 83854 Fibrinogen-related domains (FReDs) 83856 B-Box C-terminal domain 83871 Rab subfamily of small GTPases 83872 Immunoglobulin 83872 Immunoglobulin C-2 Type 83872 G2 nidogen domain and fibulin 83872 Thrombospondin type 1 repeats 83872 Calcium-binding EGF-like domain 83872 Calcium-binding EGF-like domain 83872 von Willebrand factor (vWF) type A domain 83874 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 83880 JAB/MPN domain 83886 Trypsin-like serine protease 83889 WD40 repeats 83891 Regulator of G protein signalling domain 83922 Rhodanese Homology Domain 83931 Tyrosine kinase, catalytic domain 83931 Serine/Threonine protein kinases, catalytic domain 83942 Serine/Threonine protein kinases, catalytic domain 83945 DnaJ molecular chaperone homology domain 83953 Immunoglobulin V-Type 83956 GTPase-activator protein for Rho-like GTPases 83957 Band 4.1 homologues 83964 Immunoglobulin 83983 Serine/Threonine protein kinases, catalytic domain 83984 Serine/Threonine protein kinases, catalytic domain 83990 DEAD-like helicases superfamily 83995 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 83995 Hemopexin-like repeats 83995 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 83996 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 83998 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 83999 Kringle domain 83999 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 83999 Kringle domain 83999 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 84000 Scavenger receptor Cys-rich 84000 Trypsin-like serine protease 84004 Immunoglobulin 84004 Immunoglobulin C-2 Type 84006 Tyrosine kinase, catalytic domain 84006 Extension to Ser/Thr-type protein kinases 84006 Serine/Threonine protein kinases, catalytic domain 84008 Laminin G domain 84009 Immunoglobulin 84009 Spectrin repeats 84009 Src homology 3 domains 84009 Immunoglobulin C-2 Type 84009 Fibronectin type 3 domain 84009 Serine/Threonine protein kinases, catalytic domain 84009 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 84009 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 84009 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84010 Calcium-binding EGF-like domain 84014 GTPase-activator protein for Rho-like GTPases 84016 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84018 Inositol polyphosphate phosphatase, catalytic domain homologues 84021 Phosphotyrosine-binding domain (IRS1-like) 84027 Serine/Threonine protein kinases, catalytic domain 84032 Fibrillar collagens C-terminal domain 84034 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 84035 Kringle domain 84035 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 84050 DNA/RNA non-specific endonuclease 84059 Domains in Na-Ca exchangers and integrin-beta4 84059 Pentraxin / C-reactive protein / pentaxin family 84059 G-protein-coupled receptor proteolytic site domain 84063 Immunoglobulin 84063 Immunoglobulin C-2 Type 84069 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84084 Rab subfamily of small GTPases 84124 leucine rich region 84133 Ring finger 84159 ARID (A/T-rich interaction domain) domain 84168 von Willebrand factor (vWF) type A domain 84168 von Willebrand factor (vWF) type A domain 84168 von Willebrand factor (vWF) type A domain 84171 Scavenger receptor Cys-rich 84196 Domain in ubiquitin-specific proteases 84206 Ring finger 84206 K homology RNA-binding domain 84215 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 84218 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 84249 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84254 Serine/Threonine protein kinases, catalytic domain 84254 Serine/Threonine protein kinases, catalytic domain 84254 Serine/Threonine protein kinases, catalytic domain 84271 RNA recognition motif 84271 RNA recognition motif 84285 eukaryotic translation initiation factor 1A 84307 leucine rich region 84308 Immunoglobulin V-Type 84316 snRNP Sm proteins 84324 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 84327 BED zinc finger 84333 Ring finger 84351 Serine/Threonine protein kinases, catalytic domain 84352 Fibrillar collagens C-terminal domain 84357 Src homology 3 domains 84357 Src homology 3 domains 84360 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 84365 RNA recognition motif 84382 helix loop helix domain 84386 Four-disulfide core domains 84387 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 84391 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 84394 Domain in the Doublecortin (DCX) gene product 84398 Calcium-binding EGF-like domain 84398 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 84399 Hint (Hedgehog/Intein) domain C-terminal region 84399 Hint (Hedgehog/Intein) domain N-terminal region 84401 RRM_1 domain 84401 RNA recognition motif 84407 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 84411 Serine/Threonine protein kinases, catalytic domain 84427 Src homology 2 domains 84427 Ras association (RalGDS/AF-6) domain 84427 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84433 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84433 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 84436 krueppel associated box 84439 Scavenger receptor Cys-rich 84446 Serine/Threonine protein kinases, catalytic domain 84449 krueppel associated box 84451 Src homology 3 domains 84456 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 84456 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 84460 U1-like zinc finger 84472 Double-stranded RNA binding motif 84472 domain in DSRM or ZnF_C2H2 domain containing proteins 84476 Double-stranded RNA binding motif 84476 domain in DSRM or ZnF_C2H2 domain containing proteins 84477 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84481 Tudor domain 84488 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 84489 Immunoglobulin 84489 Immunoglobulin C-2 Type 84489 Tyrosine kinase, catalytic domain 84492 Src homology 2 domains 84492 Src homology 3 domains 84492 Tyrosine kinase, catalytic domain 84492 Bruton's tyrosine kinase Cys-rich motif 84492 Serine/Threonine protein kinases, catalytic domain 84492 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 84503 krueppel associated box 84505 Tudor domain 84505 Methyl-CpG binding domain 84505 N-terminal to some SET domains 84509 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 84513 Acid phosphatase homologues 84525 Homeodomain 84525 Homeodomain 84525 Homeodomain 84547 leucine rich region 84552 PB1 domain 84552 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84556 Protein kinase C conserved region 2 (CalB) 84556 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84569 Alpha-lactalbumin / lysozyme C 84574 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 84585 Ring finger 84585 Domain in SPla and the RYanodine Receptor. 84587 Phospholipase C, catalytic domain (part) 84587 Phospholipase C, catalytic domain (part) 84587 Protein kinase C conserved region 2 (CalB) 84591 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84592 Eps15 homology domain 84592 EF-hand, calcium binding motif 84607 Src homology 2 domains 84607 suppressors of cytokine signalling 84609 semaphorin domain 84612 PB1 domain 84612 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84619 zinc finger 84619 glycine rich nucleic binding domain 84619 zinc finger 84619 zinc finger 84619 glycine rich nucleic binding domain 84623 Immunoglobulin 84628 Laminin N-terminal domain (domain VI) 84630 Tyrosine kinase, catalytic domain 84630 Serine/Threonine protein kinases, catalytic domain 84632 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84639 Interleukin-1 homologues 84639 Interleukin-1 homologues 84651 Kazal type serine protease inhibitors 84658 Calcium-binding EGF-like domain 84659 Pancreatic ribonuclease 84665 Immunoglobulin 84665 Immunoglobulin C-2 Type 84671 krueppel associated box 84674 Caspase recruitment domain 84675 Ring finger 84675 B-Box C-terminal domain 84676 Ring finger 84676 B-Box C-terminal domain 84685 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84685 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 84686 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84687 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84695 Scavenger receptor Cys-rich 84699 basic region leucin zipper 84700 Myosin. Large ATPases. ATPase 84708 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 84725 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 84727 Domain in SPla and the RYanodine Receptor. 84765 krueppel associated box 84787 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 84803 Phosphate acyltransferases 84812 Phospholipase C, catalytic domain (part) 84812 Phospholipase C, catalytic domain (part) 84812 Protein kinase C conserved region 2 (CalB) 84814 Acid phosphatase homologues 84824 Immunoglobulin 84824 Immunoglobulin C-2 Type 84838 leucine rich region 84859 Calponin homology domain 84867 Protein tyrosine phosphatase, catalytic domain 84868 Immunoglobulin 84868 Immunoglobulin V-Type 84871 Zn_pept domain 84872 zinc finger 84874 krueppel associated box 84891 leucine rich region 84894 Immunoglobulin 84897 "FY-rich" domain, C-terminal region 84897 "FY-rich" domain, N-terminal region 84898 domain found in Plexins, Semaphorins and Integrins 84904 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 84911 krueppel associated box 84918 Low-density lipoprotein receptor domain class A 84918 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 84924 krueppel associated box 84926 Domain in SPla and the RYanodine Receptor. 84929 Fibrinogen-related domains (FReDs) 84930 Serine/Threonine protein kinases, catalytic domain 84932 Rab subfamily of small GTPases 84941 Src homology 2 domains 84944 high mobility group 84948 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 84951 Src homology 2 domains 84951 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 84959 Src homology 3 domains 84961 A Receptor for Ubiquitination Targets 84962 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 84966 Immunoglobulin 84969 high mobility group 84986 GTPase-activator protein for Rho-like GTPases 84991 RRM_1 domain 84991 glycine rich nucleic binding domain 85004 Ras subfamily of RAS small GTPases 85021 Eps15 homology domain 85235 Histone 2A 85236 Histone H2B 85238 Inositol polyphosphate phosphatase, catalytic domain homologues 85240 Protein kinase C conserved region 2 (CalB) 85243 Phosphoinositide 3-kinase, catalytic domain 85244 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 85246 Fes/CIP4 homology domain 85250 Fibrillar collagens C-terminal domain 85253 Kringle domain 85253 Trypsin-like serine protease 85253 divergent subfamily of APPLE domains 85265 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 85266 Kringle domain 85266 Scavenger receptor Cys-rich 85266 Trypsin-like serine protease 85271 P or trefoil or TFF domain 85272 Transforming growth factor-beta (TGF-beta) family 85275 Src homology 3 domains 85275 domain in receptor targeting proteins Lin-2 and Lin-7 85275 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 85275 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 85300 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 85301 Fibrillar collagens C-terminal domain 85301 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 85313 RNA recognition motif 85327 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 85329 Galectin 85358 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 85360 GTPase-activator protein for Rho-like GTPases 85363 Domain in SPla and the RYanodine Receptor. 85366 Serine/Threonine protein kinases, catalytic domain 85376 Src homology 3 domains 85376 Fibronectin type 3 domain 85377 Calponin homology domain 85397 Regulator of G protein signalling domain 85415 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 85424 erythroblast transformation specific domain 85428 Rho (Ras homology) subfamily of Ras-like small GTPases 85437 RNA recognition motif 85443 Tyrosine kinase, catalytic domain 85443 Serine/Threonine protein kinases, catalytic domain 85445 Laminin G domain 85445 Fibrillar collagens C-terminal domain 85445 Laminin G domain 85445 Fibrillar collagens C-terminal domain 85446 Homeodomain 85458 Domain present in Dishevelled and axin 85461 ankyrin repeats 85462 Formin Homology 2 Domain 85464 Dual specificity phosphatase, catalytic domain 85471 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 85477 Gelsolin homology domain 85481 Serine/Threonine protein kinases, catalytic domain 85483 Leucine rich repeat, ribonuclease inhibitor type 85490 Fibrillar collagens C-terminal domain 85490 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 85496 DNA/RNA non-specific endonuclease 89122 Ring finger 89122 associated with SPRY domains 89122 Domain in SPla and the RYanodine Receptor. 89122 Ring finger 89122 associated with SPRY domains 89122 Domain in SPla and the RYanodine Receptor. 89787 Low-density lipoprotein receptor domain class A 89787 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 89789 Tudor domain 89790 Immunoglobulin 89795 ATPases associated with a variety of cellular activities 89796 ATPases associated with a variety of cellular activities 89797 ATPases associated with a variety of cellular activities 89803 Frizzled 89804 Fibronectin type 3 domain 89804 Tyrosine kinase, catalytic domain 89804 Serine/Threonine protein kinases, catalytic domain 89805 Fibrinogen-related domains (FReDs) 89807 Fibrinogen-related domains (FReDs) 89808 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 89812 Phosphatidylinositol phosphate kinases 89814 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 89817 Src homology 2 domains 89817 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 89824 Glyco_18 domain 89829 Src homology 2 domains 89829 suppressors of cytokine signalling 89843 Immunoglobulin 89843 Immunoglobulin V-Type 89846 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 89846 Protein present in Fab1, YOTB, Vac1, and EEA1 89846 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 89846 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 89848 Src homology 3 domains 89849 WD40 repeats 89857 Kelch domain 89858 Immunoglobulin 89858 Immunoglobulin 89869 Phospholipase C, catalytic domain (part) 89869 Phospholipase C, catalytic domain (part) 89869 Protein kinase C conserved region 2 (CalB) 89870 associated with SPRY domains 89870 Domain in SPla and the RYanodine Receptor. 89910 Domain Homologous to E6-AP Carboxyl Terminus with 89932 Thrombospondin type 1 repeats 89941 Rho (Ras homology) subfamily of Ras-like small GTPases 89970 Domain in SPla and the RYanodine Receptor. 90007 Ubiquitin homologues 90102 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 90134 Cyclic nucleotide-monophosphate binding domain 90167 Band 4.1 homologues 90199 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 90199 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 90199 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 90233 krueppel associated box 90249 Immunoglobulin 90249 Immunoglobulin C-2 Type 90249 Thrombospondin type 1 repeats 90249 Domain present in ZO-1 and Unc5-like netrin receptors 90249 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 90273 Immunoglobulin 90274 G protein gamma subunit-like motifs 90293 Kelch domain 90293 Broad-Complex, Tramtrack and Bric a brac 90316 Homeodomain 90317 krueppel associated box 90321 krueppel associated box 90326 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 90338 krueppel associated box 90342 Protein kinase C conserved region 2 (CalB) 90346 krueppel associated box 90378 SAM / Pointed domain 90378 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 90462 krueppel associated box 90525 Src homology 2 domains 90576 krueppel associated box 90592 krueppel associated box 90627 GTPase-activator protein for Rho-like GTPases 90627 in StAR and phosphatidylcholine transfer protein 90649 krueppel associated box 90655 Homeodomain 90665 Lissencephaly type-1-like homology motif 90665 Lissencephaly type-1-like homology motif 90665 Lissencephaly type-1-like homology motif 90787 Immunoglobulin 90787 Immunoglobulin V-Type 90816 krueppel associated box 90827 krueppel associated box 90853 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 90925 Immunoglobulin V-Type 90933 associated with SPRY domains 90933 Domain in SPla and the RYanodine Receptor. 90952 Immunoglobulin 90987 krueppel associated box 90990 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 90993 basic region leucin zipper 91010 Formin Homology 2 Domain 91107 B-Box-type zinc finger 91107 Ring finger 91107 B-Box-type zinc finger 91107 Domain in SPla and the RYanodine Receptor. 91115 krueppel associated box 91120 krueppel associated box 91133 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 91151 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 91156 Immunoglobulin 91156 Immunoglobulin C-2 Type 91156 Fibronectin type 3 domain 91156 Immunoglobulin 91156 Immunoglobulin C-2 Type 91156 Fibronectin type 3 domain 91351 helicase superfamily c-terminal domain 91353 Immunoglobulin C-Type 91355 Low-density lipoprotein-receptor YWTD domain 91355 Low-density lipoprotein-receptor YWTD domain 91404 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 91461 Tyrosine kinase, catalytic domain 91461 Serine/Threonine protein kinases, catalytic domain 91464 Homeodomain 91544 Domain of unknown function present in FAF1 (Fas-associated factor 1) 91584 semaphorin domain 91584 semaphorin domain 91603 U1-like zinc finger 91608 Ras subfamily of RAS small GTPases 91614 Domain found in Dishevelled, Egl-10, and Pleckstrin 91624 Immunoglobulin 91653 Immunoglobulin 91653 Immunoglobulin C-2 Type 91683 Protein kinase C conserved region 2 (CalB) 91754 Serine/Threonine protein kinases, catalytic domain 91807 Serine/Threonine protein kinases, catalytic domain 91807 Tyrosine kinase, catalytic domain 91807 Serine/Threonine protein kinases, catalytic domain 91975 krueppel associated box 92017 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 92211 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 92267 domain involved in Ras-like GTPase signaling 92285 krueppel associated box 92291 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 92312 K homology RNA-binding domain 92335 Serine/Threonine protein kinases, catalytic domain 92369 suppressors of cytokine signalling 92369 Domain in SPla and the RYanodine Receptor. 92400 RNA recognition motif 92565 Fibronectin type 3 domain 92579 Acid phosphatase homologues 92595 krueppel associated box 92609 catalytic domain of ctd-like phosphatases 92737 Calcium-binding EGF-like domain 92747 BPI/LBP/CETP C-terminal domain 92747 BPI/LBP/CETP N-terminal domain 92806 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 92815 Histone 2A 92906 RNA recognition motif 92949 Thrombospondin type 1 repeats 92949 Thrombospondin type 1 repeats 92949 Thrombospondin type 1 repeats 93134 Eps15 homology domain 93145 Olfactomedin-like domains 93166 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 93185 Immunoglobulin 93273 in nuclear membrane-associated proteins 93589 von Willebrand factor (vWF) type A domain 93624 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 93624 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 93627 Rhodanese Homology Domain 93627 Serine/Threonine protein kinases, catalytic domain 93627 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 93659 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 93662 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93663 GTPase-activator protein for Rho-like GTPases 93664 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 93667 Olfactomedin-like domains 93671 Scavenger receptor Cys-rich 93675 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93679 Ring finger 93679 B-Box C-terminal domain 93681 leucine rich region 93686 RNA recognition motif 93686 RNA recognition motif 93688 Kelch domain 93694 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93695 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 93699 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93700 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93701 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93702 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93703 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93704 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93705 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93706 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93707 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93708 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93709 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93710 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93711 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93712 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93712 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93713 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93714 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93714 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93715 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93716 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93717 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93719 Pancreatic ribonuclease 93722 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93723 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93724 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93725 Pancreatic ribonuclease 93726 Pancreatic ribonuclease 93728 RNA recognition motif 93737 PB1 domain 93737 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 93742 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 93761 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 93762 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 93762 DEAD-like helicases superfamily 93762 helicase superfamily c-terminal domain 93762 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 93842 Immunoglobulin 93842 Immunoglobulin C-2 Type 93843 Serine/Threonine protein kinases, catalytic domain 93871 bromo domain 93872 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93873 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93874 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93875 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93876 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93877 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93878 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93879 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93880 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93881 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93882 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93883 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93884 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93885 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93886 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93887 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93888 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93889 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93890 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93891 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93892 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93893 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 93897 Frizzled 93967 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93968 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93969 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93970 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93971 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 93979 Zn_pept domain 93986 FORKHEAD 93986 FORKHEAD 93986 FORKHEAD 93986 FORKHEAD 94027 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 94030 Leucine rich repeat C-terminal domain 94059 zinc finger 94071 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 94088 Ring finger 94088 B-Box-type zinc finger 94088 associated with SPRY domains 94088 Domain in SPla and the RYanodine Receptor. 94090 B-Box-type zinc finger 94090 B-Box C-terminal domain 94090 Fibronectin type 3 domain 94090 Domain in SPla and the RYanodine Receptor. 94091 associated with SPRY domains 94092 associated with SPRY domains 94092 Domain in SPla and the RYanodine Receptor. 94093 B-Box C-terminal domain 94109 Domain abundant in complement control proteins 94109 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 94115 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 94116 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 94120 Protein kinase C conserved region 2 (CalB) 94122 Protein kinase C conserved region 2 (CalB) 94134 Domain with 2 conserved Trp (W) residues 94134 GTPase-activator protein for Rho-like GTPases 94134 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 94137 Domain in the Doublecortin (DCX) gene product 94168 Cystatin-like domain 94176 Src homology 3 domains 94190 GTPase-activator protein for Rho-like GTPases 94190 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 94191 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 94197 Rab subfamily of small GTPases 94201 Serine/Threonine protein kinases, catalytic domain 94202 Protein tyrosine phosphatase, catalytic domain 94203 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 94214 Kazal type serine protease inhibitors 94216 C-terminal tandem repeated domain in type 4 procollagens 94217 Low-density lipoprotein-receptor YWTD domain 94217 Low-density lipoprotein receptor domain class A 94221 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 94223 Domain with 2 conserved Trp (W) residues 94223 Domain with 2 conserved Trp (W) residues 94225 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 94227 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 94228 Ependymins 94232 Ubiquitin associated domain 94235 G protein gamma subunit-like motifs 94239 Histone 2A 94239 Histone 2A 94253 Domain with 2 conserved Trp (W) residues 94253 Protein kinase C conserved region 2 (CalB) 94253 Domain Homologous to E6-AP Carboxyl Terminus with 94332 Immunoglobulin 94339 ShK toxin domain 94339 Immunoglobulin C-2 Type 94352 Scavenger receptor Cys-rich 94352 Scavenger receptor Cys-rich 95681 Rhodanese Homology Domain 96597 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 96935 Domain abundant in complement control proteins 97064 Domain with 2 conserved Trp (W) residues 97114 Histone H3 97114 Histone 2A 97114 Histone H3 97122 Histone H4 97165 high mobility group 97795 Laminin N-terminal domain (domain VI) 97848 SERine Proteinase INhibitors 97908 Histone H3 97998 Domain found in Dishevelled, Egl-10, and Pleckstrin 98027 glycine rich nucleic binding domain 98221 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 98267 Serine/Threonine protein kinases, catalytic domain 98386 Tudor domain 98432 Serine/threonine phosphatases, family 2C, catalytic domain 98432 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 98558 high mobility group 98733 Immunoglobulin 98733 Immunoglobulin C-2 Type 98733 Immunoglobulin 98733 Immunoglobulin C-2 Type 98733 Fibronectin type 3 domain 98752 Immunoglobulin 98752 Immunoglobulin C-2 Type 98758 RNA recognition motif 98758 RNA recognition motif 98845 Src homology 3 domains 98845 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 98848 Anaphylatoxin homologous domain 98878 Eps15 homology domain 98910 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 98910 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 98932 EF-hand, calcium binding motif 98970 Fibrinogen-related domains (FReDs) 99010 Phosphate acyltransferases 99138 in StAR and phosphatidylcholine transfer protein 99152 Cullin 99152 Cullin 99326 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 99326 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 99334 leucine rich region 99382 Histone 2A 99382 ankyrin repeats 99382 Broad-Complex, Tramtrack and Bric a brac 99439 EF-hand, calcium binding motif 99470 Domain with 2 conserved Trp (W) residues 99470 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 99470 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 99512 C-terminal to LisH motif. 99512 WD40 repeats 99512 C-terminal to LisH motif. 99633 G-protein-coupled receptor proteolytic site domain 99662 Src homology 3 domains 99662 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 99663 von Willebrand factor (vWF) type A domain 99683 Gelsolin homology domain 99696 ankyrin repeats 99887 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 99887 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 100017 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 100169 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 100169 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 100213 domain involved in Ras-like GTPase signaling 100317 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 100732 Calponin homology domain 100763 Domain Homologous to E6-AP Carboxyl Terminus with 100763 Domain Homologous to E6-AP Carboxyl Terminus with 100855 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 100951 helix loop helix domain 100952 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 100972 ARF-like small GTPases 100972 Rab subfamily of small GTPases 100972 Ras subfamily of RAS small GTPases 100972 Rho (Ras homology) subfamily of Ras-like small GTPases 100972 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 101095 krueppel associated box 101187 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 101187 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 101202 Immunoglobulin C-2 Type 101202 Immunoglobulin 101202 Immunoglobulin C-2 Type 101240 WD40 repeats 101320 Tyrosine kinase, catalytic domain 101320 erine/Threonine protein kinases, catalytic domain 101320 Serine/Threonine protein kinases, catalytic domain 101434 Immunoglobulin 101434 Immunoglobulin C-2 Type 101476 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 101497 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 101497 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 101533 Trypsin-like serine protease 101540 Serine/Threonine protein kinases, catalytic domain 101700 Ring finger 101700 B-Box-type zinc finger 101809 WASP homology region 1 101964 SAM / Pointed domain 101964 Sterile alpha motif 101964 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 102060 Ubiquitin associated domain 102075 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 102075 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 102141 Regulator of G protein signalling domain 102141 PhoX homologous domain, present in p47phox and p40phox 102141 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 102247 Phosphate acyltransferases 102278 von Willebrand factor (vWF) type A domain 102278 von Willebrand factor (vWF) type A domain 102414 Serine/Threonine protein kinases, catalytic domain 102502 Calponin homology domain 102595 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 102607 PhoX homologous domain, present in p47phox and p40phox 102607 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 102626 Tyrosine kinase, catalytic domain 102626 erine/Threonine protein kinases, catalytic domain 102626 Serine/Threonine protein kinases, catalytic domain 102657 Immunoglobulin V-Type 102657 Immunoglobulin C-2 Type 102693 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 102774 Tetratricopeptide repeats 103135 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 103135 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 103284 zinc finger 103296 Tyrosine kinase, catalytic domain 103296 erine/Threonine protein kinases, catalytic domain 103296 Serine/Threonine protein kinases, catalytic domain 103406 domain in DSRM or ZnF_C2H2 domain containing proteins 103537 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 103583 A Receptor for Ubiquitination Targets 103655 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 103724 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 103737 Ring finger 103784 WD40 repeats 103841 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 104002 Papain family cysteine protease 104010 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 104082 WD40 repeats 104099 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 104099 Integrin alpha (beta-propellor repeats) 104099 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 104175 Serine/Threonine protein kinases, catalytic domain 104183 Glyco_18 domain 104183 Glyco_18 domain 104215 Rho (Ras homology) subfamily of Ras-like small GTPases 104252 P21-Rho-binding domain 104348 krueppel associated box 104360 Homeodomain 104383 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 104418 Diacylglycerol kinase accessory domain (presumed) 104418 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 104418 ankyrin repeats 104418 Diacylglycerol kinase accessory domain (presumed) 104418 Diacylglycerol kinase catalytic domain (presumed) 104418 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 104652 Myosin. Large ATPases 104652 Myosin. Large ATPases. ATPase 104721 Domain in SPla and the RYanodine Receptor. 104759 Phospholipase D. Active site motifs 104759 Phospholipase D. Active site motifs. Phosphatidylcholine-hydrolyzing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of cert 104859 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 104859 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 104886 Rab subfamily of small GTPases 105033 Spectrin repeats 105072 Plectin repeat 105246 bromo domain 105278 Serine/Threonine protein kinases, catalytic domain 105298 Ependymins 105352 Dual specificity phosphatase, catalytic domain 105372 WD40 repeats 105450 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 105540 ankyrin repeats 105594 Homeodomain 105670 Broad-Complex, Tramtrack and Bric a brac 105734 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 105734 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 105782 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 105787 Tyrosine kinase, catalytic domain 105787 erine/Threonine protein kinases, catalytic domain 105787 Serine/Threonine protein kinases, catalytic domain 105827 Immunoglobulin 105827 Immunoglobulin 105827 Immunoglobulin C-2 Type 105835 Src homology 3 domains 105835 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 105892 Ly-6 antigen / uPA receptor -like domain 106021 Ring finger 106052 A Receptor for Ubiquitination Targets 106326 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 106504 Extension to Ser/Thr-type protein kinases 106504 Serine/Threonine protein kinases, catalytic domain 106522 Tyrosine kinase, catalytic domain 106522 erine/Threonine protein kinases, catalytic domain 106583 RNA recognition motif 106583 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 106583 RNA recognition motif 106597 Ribosomal protein S1-like RNA-binding domain 106597 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 106618 WD40 repeats 106628 Src homology 3 domains 106759 Toll - interleukin 1 - resistance 106766 Src homology 2 domains 106794 zinc finger 106794 DEAD-like helicases superfamily 106794 helicase superfamily c-terminal domain 106877 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 106877 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 106952 GTPase-activator protein for Rho-like GTPases 106952 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 106952 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 107022 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 107182 DEAD-like helicases superfamily 107182 helicase superfamily c-terminal domain 107250 Immunoglobulin 107250 Insulin growth factor-binding protein homologues 107250 Immunoglobulin 107250 Immunoglobulin C-2 Type 107250 Kazal type serine protease inhibitors 107250 Insulin growth factor-binding protein homologues 107338 Sec7 domain 107351 ankyrin repeats 107368 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 107393 Laminin-type epidermal growth factor-like domai 107393 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 107448 Immunoglobulin 107448 Thrombospondin type 1 repeats 107448 Domain present in ZO-1 and Unc5-like netrin receptors 107448 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 107449 Immunoglobulin 107449 Thrombospondin type 1 repeats 107449 Domain present in ZO-1 and Unc5-like netrin receptors 107449 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 107503 basic region leucin zipper 107527 Immunoglobulin 107527 Immunoglobulin C-2 Type 107568 Protein kinase C conserved region 2 (CalB) 107568 Domain with 2 conserved Trp (W) residues 107568 Protein kinase C conserved region 2 (CalB) 107568 Domain Homologous to E6-AP Carboxyl Terminus with 107589 Immunoglobulin 107589 Immunoglobulin 107589 Immunoglobulin C-2 Type 107589 Fibronectin type 3 domain 107589 Tyrosine kinase, catalytic domain 107589 Serine/Threonine protein kinases, catalytic domain 107650 Phosphoinositide 3-kinase, catalytic domain 107650 Phosphoinositide 3-kinase, catalytic domain 107684 WD40 repeats 107686 snRNP Sm proteins 107746 Guanine nucleotide exchange factor for Ras-like GTPases 107746 Guanine nucleotide exchange factor for Ras-like small GTPases 107751 Homeodomain 107815 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 107823 PHD zinc finger 107823 associated with SET domains 107823 domain with conserved PWWP motif 107823 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 107831 Thrombospondin type 1 repeats 107932 PHD zinc finger 107932 DEAD-like helicases superfamily 107932 Chromatin organization modifier domain 107934 Laminin G domain 107934 Calcium-binding EGF-like domain 107934 Domain present in hormone receptors 107934 G-protein-coupled receptor proteolytic site domain 107934 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 107951 Serine/Threonine protein kinases, catalytic domain 107986 WD40 repeats 108013 RNA recognition motif 108013 RNA recognition motif 108013 RNA recognition motif 108014 RNA recognition motif 108030 Domain present in PSD-95, Dlg, and ZO-1/2 108030 domain in receptor targeting proteins Lin-2 and Lin-7 108030 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 108058 Serine/Threonine protein kinases, catalytic domain 108062 RNA recognition motif 108075 Calcium-binding EGF-like domain 108075 Calcium-binding EGF-like domain 108077 helicase superfamily c-terminal domain 108078 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 108079 Tyrosine kinase, catalytic domain 108079 Serine/Threonine protein kinases, catalytic domain 108083 Phosphatidylinositol phosphate kinases 108083 Phosphatidylinositol phosphate kinases 108100 Src homology 3 domains 108101 Band 4.1 homologues 108101 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 108121 RRM_1 domain 108148 Ricin-type beta-trefoil 108150 Ricin-type beta-trefoil 108151 domain found in Plexins, Semaphorins and Integrins 108151 semaphorin domain 108151 domain found in Plexins, Semaphorins and Integrins 108154 Thrombospondin type 1 repeats 108655 FORKHEAD 108723 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 108723 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 108723 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 108760 Ricin-type beta-trefoil 108837 Broad-Complex, Tramtrack and Bric a brac 108888 ATPases associated with a variety of cellular activities 108946 Zinc-binding domain, present in Dystrophin, CREB-binding protein 108946 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 108960 Tyrosine kinase, catalytic domain 108960 erine/Threonine protein kinases, catalytic domain 108960 Serine/Threonine protein kinases, catalytic domain 108995 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 109095 RNA recognition motif 109137 G protein alpha subunit 109137 ARF-like small GTPases 109137 Rab subfamily of small GTPases 109137 Ras subfamily of RAS small GTPases 109137 Rho (Ras homology) subfamily of Ras-like small GTPases 109137 Sar1p-like members of the Ras-family of small GTPases 109137 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 109151 domain in transcription and CHROMO domain helicases 109161 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 109267 Scavenger receptor Cys-rich 109272 Immunoglobulin 109272 Immunoglobulin 109272 Immunoglobulin C-2 Type 109275 Actin 109284 Putative single-stranded nucleic acids-binding domain 109323 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 109323 Complement component C1q domain 109323 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 109331 Ring finger 109333 Serine/Threonine protein kinases, catalytic domain 109333 Tyrosine kinase, catalytic domain 109333 Extension to Ser/Thr-type protein kinases 109333 erine/Threonine protein kinases, catalytic domain 109333 Serine/Threonine protein kinases, catalytic domain 109346 ankyrin repeats 109588 Myosin. Large ATPases. ATPase 109596 Short calmodulin-binding motif containing conserved Ile and Gln residues 109596 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 109660 Trypsin-like serine protease 109676 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 109676 ankyrin repeats 109697 Zn_pept domain 109711 Spectrin repeats 109711 EF-hand, calcium binding motif 109791 Colipase 109821 APPLE domain 109821 Trypsin-like serine protease 109880 B-Box C-terminal domain 109889 leucine rich region 109901 Trypsin-like serine protease 109901 Trypsin-like serine protease 109904 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 109904 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 109905 Ras subfamily of RAS small GTPases 109929 Broad-Complex, Tramtrack and Bric a brac 110033 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 110052 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 110052 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 110058 Protein kinase C conserved region 2 (CalB) 110075 Transforming growth factor-beta (TGF-beta) family 110135 Fibrinogen-related domains (FReDs) 110197 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 110253 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 110253 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 110279 Protein kinase C conserved region 2 (CalB) 110279 GTPase-activator protein for Rho-like GTPases 110279 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 110332 Serine/threonine phosphatases, family 2C, catalytic domain 110351 LGN motif, putative GEFs specific for G-alpha GTPases 110355 Tyrosine kinase, catalytic domain 110355 Extension to Ser/Thr-type protein kinases 110355 Regulator of G protein signalling domain 110355 erine/Threonine protein kinases, catalytic domain 110355 Serine/Threonine protein kinases, catalytic domain 110355 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 110382 Thrombospondin type 1 repeats 110382 Thrombospondin type 1 repeats 110382 membrane-attack complex / perforin 110454 Ly-6 antigen / uPA receptor -like domain 110524 Ras association (RalGDS/AF-6) domain 110524 Diacylglycerol kinase catalytic domain (presumed) 110524 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 110532 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 110596 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 110611 K homology RNA-binding domain 110611 K homology RNA-binding domain 110637 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 110637 Bacterial periplasmic substrate-binding proteins 110637 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 110651 Serine/Threonine protein kinases, catalytic domain 110751 ADAM Cysteine-Rich Domain 110751 Homologues of snake disintegrins 110789 LamG-like jellyroll fold domain 110789 Domains in Na-Ca exchangers and integrin-beta4 110805 FORKHEAD 110809 RNA recognition motif 110816 WD40 repeats 110855 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 110891 Domains in Na-Ca exchangers and integrin-beta4 110893 Domains in Na-Ca exchangers and integrin-beta4 112398 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112398 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112398 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112399 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112400 Immunoglobulin 112401 Baculoviral inhibition of apoptosis protein repeat 112405 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112406 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112407 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 112574 Src homology 3 domains 112611 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 113026 Phospholipase C, catalytic domain (part) 113026 Phospholipase C, catalytic domain (part) 113251 RNA recognition motif 113791 Kringle domain 113835 krueppel associated box 113878 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 113886 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 113894 PB1 domain 113894 Ubiquitin associated domain 113894 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 113894 PB1 domain 113894 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t 113894 PB1 domain 113894 Ubiquitin associated domain 113894 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 113901 Glyco_18 domain 113901 Chitin-binding domain type 2 113907 Serine/Threonine protein kinases, catalytic domain 113911 Tyrosine kinase, catalytic domain 113911 Adenylyl- / guanylyl cyclase, catalytic domain 113936 Zn_pept domain 113937 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 113940 Actin depolymerisation factor/cofilin -like domains 113955 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 113960 P21-Rho-binding domain 113960 Serine/Threonine protein kinases, catalytic domain 113970 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 113970 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 114026 krueppel associated box 114031 Kazal type serine protease inhibitors 114032 Cyclic nucleotide-monophosphate binding domain 114088 B-Box-type zinc finger 114088 B-Box C-terminal domain 114088 B-Box-type zinc finger 114088 B-Box C-terminal domain 114089 Inositol polyphosphate phosphatase, catalytic domain homologues 114091 Fibrinogen-related domains (FReDs) 114093 Trypsin-like serine protease 114093 Low-density lipoprotein receptor domain class A 114093 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 114102 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 114107 Kringle domain 114107 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 114108 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 114110 Immunoglobulin 114110 Immunoglobulin C-2 Type 114110 Tyrosine kinase, catalytic domain 114111 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 114116 P21-Rho-binding domain 114116 Serine/Threonine protein kinases, catalytic domain 114116 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114119 G protein gamma subunit-like motifs 114124 K homology RNA-binding domain 114132 Immunoglobulin 114132 Immunoglobulin V-Type 114142 FORKHEAD 114200 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 114203 Src homology 2 domains 114203 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114205 DNA-directed RNA-polymerase II subunit 114212 Serine/Threonine protein kinases, catalytic domain 114228 Trypsin-like serine protease 114228 Trypsin-like serine protease 114244 Cyclic nucleotide-monophosphate binding domain 114249 Calcium-binding EGF-like domain 114249 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 114255 Phosphotyrosine-binding domain (IRS1-like) 114255 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114327 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 114332 Link (Hyaluronan-binding) 114332 Link (Hyaluronan-binding) 114335 Glycoprotein hormone beta chain homologues. 114336 Glycoprotein hormone beta chain homologues. 114482 Tyrosine kinase, catalytic domain 114482 Serine/Threonine protein kinases, catalytic domain 114492 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). 114494 domain present in cyclins, TFIIB and Retinoblastoma 114495 Serine/Threonine protein kinases, catalytic domain 114498 Doublesex DNA-binding motif 114500 Homeodomain 114502 Homeodomain 114502 Paired Box domain 114503 Homeodomain 114504 Homeodomain 114511 Immunoglobulin 114513 Guanine nucleotide exchange factor for Ras-like GTPases 114513 Guanine nucleotide exchange factor for Ras-like small GTPases 114513 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114517 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 114519 basic region leucin zipper 114523 Netrin C-terminal Domain 114523 Laminin N-terminal domain (domain VI) 114524 Laminin N-terminal domain (domain VI) 114524 Laminin-type epidermal growth factor-like domai 114552 BCL (B-Cell lymphoma) 114553 Src homology 3 domains 114553 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 114555 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 114557 Wnt-inhibitory factor-1 like domain 114559 Src homology 3 domains 114559 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 114559 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114560 Ras subfamily of RAS small GTPases 114589 Immunoglobulin 114589 Immunoglobulin C-2 Type 114590 Ubiquitin associated domain 114592 Serine/Threonine protein kinases, catalytic domain 114593 Natriuretic peptide 114596 Four-disulfide core domains 114601 Calponin homology domain 114609 Toll - interleukin 1 - resistance 114609 Toll - interleukin 1 - resistance 114625 Immunoglobulin V-Type 114625 associated with SPRY domains 114625 Domain in SPla and the RYanodine Receptor. 114633 Ras association (RalGDS/AF-6) domain 114633 Phospholipase C, catalytic domain (part) 114633 Phospholipase C, catalytic domain (part) 114633 Guanine nucleotide exchange factor for Ras-like small GTPases 114634 Homeodomain 114642 bromo domain 114661 Trypsin-like serine protease 114662 Trypsin-like serine protease 114668 Found in Skp1 protein family 114675 WD40 repeats 114705 Regulator of G protein signalling domain 114713 Bruton's tyrosine kinase Cys-rich motif 114713 GTPase-activator protein for Ras-like GTPases 114715 WASP homology region 1 114716 WASP homology region 1 114767 Dual specificity phosphatase, catalytic domain 114767 Protein tyrosine phosphatase, catalytic domain 114767 Protein tyrosine phosphatase, catalytic domain motif 114770 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 114771 Ami_2 domain 114771 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 114780 G-protein-coupled receptor proteolytic site domain 114780 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 114780 G-protein-coupled receptor proteolytic site domain 114780 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 114780 Lipoxygenase homology 2 (beta barrel) domain 114780 G-protein-coupled receptor proteolytic site domain 114783 Tyrosine kinase, catalytic domain 114783 Serine/Threonine protein kinases, catalytic domain 114784 Domain abundant in complement control proteins 114784 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 114784 Domain abundant in complement control proteins 114785 Methyl-CpG binding domain 114788 Domain abundant in complement control proteins 114788 Domain abundant in complement control proteins 114788 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 114788 Domain abundant in complement control proteins 114793 Formin Homology 2 Domain 114798 Leucine rich repeat C-terminal domain 114803 JAB/MPN domain 114805 Ricin-type beta-trefoil 114815 VPS10 domain 114821 leucine rich region 114822 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 114825 domain with conserved PWWP motif 114826 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 114839 domain present in cyclins, TFIIB and Retinoblastoma 114856 Rhodanese Homology Domain 114859 Tyrosine kinase, catalytic domain 114859 Serine/Threonine protein kinases, catalytic domain 114859 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 114871 Immunoglobulin 114875 Phospholipase C, catalytic domain (part) 114875 Phospholipase C, catalytic domain (part) 114875 Protein kinase C conserved region 2 (CalB) 114879 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114880 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114880 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114881 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114881 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114882 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114883 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114883 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114883 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114884 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114885 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 114897 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114898 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114900 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114901 Src homology 3 domains 114902 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114904 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114904 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114905 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 114971 Dual specificity phosphatase, catalytic domain 114971 Protein tyrosine phosphatase, catalytic domain motif 115281 Immunoglobulin 115281 Immunoglobulin V-Type 115290 A Receptor for Ubiquitination Targets 115290 A Receptor for Ubiquitination Targets 115350 Immunoglobulin 115352 Immunoglobulin 115442 Protein tyrosine phosphatase, catalytic domain 115509 krueppel associated box 115548 Fes/CIP4 homology domain 115557 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 115648 krueppel associated box 115653 Immunoglobulin C-2 Type 115669 Tetratricopeptide repeats 115677 Src homology 3 domains 115701 Immunoglobulin 115703 Src homology 3 domains 115703 GTPase-activator protein for Rho-like GTPases 115704 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 115727 Guanine nucleotide exchange factor for Ras-like GTPases 115727 Guanine nucleotide exchange factor for Ras-like GTPases 115727 Guanine nucleotide exchange factor for Ras-like small GTPases 115727 Guanine nucleotide exchange factor for Ras-like GTPases 115727 Guanine nucleotide exchange factor for Ras-like small GTPases 115727 Guanine nucleotide exchange factor for Ras-like GTPases 115727 Guanine nucleotide exchange factor for Ras-like small GTPases 115768 krueppel associated box 115992 Ring finger 116068 Lysin motif 116113 FORKHEAD 116135 Leucine rich repeat N-terminal domain 116238 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 116442 Rab subfamily of small GTPases 116443 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 116444 Bacterial periplasmic substrate-binding proteins 116444 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 116447 DNA Topoisomerase I (eukaryota) 116448 helix loop helix domain 116456 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 116457 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 116459 SERine Proteinase INhibitors 116466 found in Wnt-1 116470 Syntaxin N-terminal domain 116470 Helical region found in SNAREs 116477 Serine/Threonine protein kinases, catalytic domain 116479 Immunoglobulin 116487 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 116500 Helical region found in SNAREs 116501 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 116504 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116506 Domain present in hormone receptors 116508 Laminin G domain 116543 helix loop helix domain 116544 Found in Pit-Oct-Unc transcription factors 116546 Ras subfamily of RAS small GTPases 116548 Furin-like repeats 116552 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 116553 Interleukins 4 and 13 116556 Tyrosine kinase, catalytic domain 116556 Adenylyl- / guanylyl cyclase, catalytic domain 116562 Interleukin-2 family 116564 Adenylyl- / guanylyl cyclase, catalytic domain 116590 Serine/Threonine protein kinases, catalytic domain 116591 Immunoglobulin 116595 Laminin G domain 116596 Serine/Threonine protein kinases, catalytic domain 116597 Immunoglobulin 116597 Immunoglobulin C-2 Type 116600 Src homology 3 domains 116639 Homeodomain 116641 Galectin 116655 RNA recognition motif 116658 Immunoglobulin 116658 Immunoglobulin C-2 Type 116660 Protein tyrosine phosphatase, catalytic domain 116663 Rhodanese Homology Domain 116667 Serine/Threonine protein kinases, catalytic domain 116674 basic region leucin zipper 116687 deoxyribonuclease I 116689 Protein tyrosine phosphatase, catalytic domain 116690 Immunoglobulin 116691 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116692 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116693 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116694 calpain_III domain 116694 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 116701 Immunoglobulin 116701 Immunoglobulin C-2 Type 116711 Immunoglobulin 116717 Src homology 3 domains 116718 Ring finger 116720 Protein kinase C conserved region 2 (CalB) 116720 Phosphoinositide 3-kinase, catalytic domain 116720 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 116720 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 116731 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 116742 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 116743 BAR domain 116743 Src homology 3 domains 116745 Cyclic nucleotide-monophosphate binding domain 116780 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 116782 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 116808 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 116810 FORKHEAD 116838 Protein kinase C conserved region 2 (CalB) 116838 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 116839 Protein kinase C conserved region 2 (CalB) 116839 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 116839 Protein kinase C conserved region 2 (CalB) 116848 bromo domain 116848 Methyl-CpG binding domain 116870 Bromo adjacent homology domain 116870 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 116870 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 116870 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 116871 Bromo adjacent homology domain 116871 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 116871 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 116873 Sterile alpha motif 116873 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 116903 calcitonin 116904 Immunoglobulin 116972 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 116983 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116984 GTPase-activator protein for Rho-like GTPases 116984 Putative GTP-ase activating proteins for the small GTPase, ARF 116984 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116984 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 116984 GTPase-activator protein for Rho-like GTPases 116984 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116985 GTPase-activator protein for Rho-like GTPases 116985 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116985 GTPase-activator protein for Rho-like GTPases 116985 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116986 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116987 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116988 Ras subfamily of RAS small GTPases 116988 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 116996 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 116998 LamG-like jellyroll fold domain 116998 Pentraxin / C-reactive protein / pentaxin family 116999 Ring finger 116999 Domain in SPla and the RYanodine Receptor. 117016 Ubiquitin associated domain 117016 Serine/Threonine protein kinases, catalytic domain 117018 Cyclic nucleotide-monophosphate binding domain 117020 Spectrin repeats 117020 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 117022 Immunoglobulin 117026 Domain with 2 conserved Trp (W) residues 117028 Src homology 3 domains 117033 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 117048 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 117049 Rab subfamily of small GTPases 117056 Histone H3 117057 Myosin. Large ATPases. ATPase 117060 Domain Homologous to E6-AP Carboxyl Terminus with 117060 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 117061 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 117063 Protein tyrosine phosphatase, catalytic domain 117065 Homeodomain 117066 Papain family cysteine protease 117087 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 117088 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 117092 SERine Proteinase INhibitors 117094 Kringle domain 117095 Orange domain 117130 Galectin 117146 Domain Homologous to E6-AP Carboxyl Terminus with 117149 Toll - interleukin 1 - resistance 117150 Phosphatidylinositol phosphate kinases 117157 Src homology 2 domains 117166 Immunoglobulin 117166 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 117179 Zona pellucida (ZP) domain 117179 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 117180 Cold shock protein domain 117184 Trypsin-like serine protease 117198 Kelch domain 117229 Tyrosine kinase, catalytic domain 117229 erine/Threonine protein kinases, catalytic domain 117229 Serine/Threonine protein kinases, catalytic domain 117229 Tyrosine kinase, catalytic domain 117229 erine/Threonine protein kinases, catalytic domain 117229 Serine/Threonine protein kinases, catalytic domain 117248 Ricin-type beta-trefoil 117255 Protein tyrosine phosphatase, catalytic domain 117258 Immunoglobulin 117258 Immunoglobulin C-2 Type 117259 RNA recognition motif 117273 Rho (Ras homology) subfamily of Ras-like small GTPases 117277 Epsin N-terminal homology (ENTH) domain 117282 K homology RNA-binding domain 117284 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 117289 GTPase-activator protein for Rho-like GTPases 117289 GTPase-activator protein for Rho-like GTPases 117289 GTPase-activator protein for Rho-like GTPases 117516 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 117518 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 117519 Kelch domain 117520 domain in TBC and LysM domain containing proteins 117538 Wiskott Aldrich syndrome homology region 2 117541 C-terminal to LisH motif. 117541 Lissencephaly type-1-like homology motif 117542 Src homology 3 domains 117545 Serine/Threonine protein kinases, catalytic domain 117547 Immunoglobulin 117548 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 117548 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 117548 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 117548 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 117550 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 117552 Protein tyrosine phosphatase, catalytic domain 117554 Lipoxygenase homology 2 (beta barrel) domain 117558 Serine/Threonine protein kinases, catalytic domain 117579 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 117583 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 117583 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 117600 Src homology 3 domains 117600 GTPase-activator protein for Rho-like GTPases 117601 Src homology 3 domains 117601 GTPase-activator protein for Rho-like GTPases 117606 Immunoglobulin 117606 Immunoglobulin C-2 Type 117608 krueppel associated box 117854 associated with SPRY domains 118427 Olfactomedin-like domains 118454 Connexin homologues 118704 Putative GTP-ase activating proteins for the small GTPase, ARF 118704 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 118706 Putative GTP-ase activating proteins for the small GTPase, ARF 118706 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 118709 Scavenger receptor Cys-rich 118813 Protein present in Fab1, YOTB, Vac1, and EEA1 118856 Zinc-dependent metalloprotease 118856 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 118945 Papain family cysteine protease 118987 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 118992 Homeodomain 119016 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 119180 Alpha-lactalbumin / lysozyme C 119358 snRNP Sm proteins 119587 Zn_pept domain 119587 Coagulation factor 5/8 C-terminal domain, discoidin domain 119593 Ras association (RalGDS/AF-6) domain 120082 Small domain found in the jumonji family of transcription factors 120082 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 120084 Small domain found in the jumonji family of transcription factors 120084 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 120105 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 120114 Laminin G domain 120123 Ring finger 120123 Domain in SPla and the RYanodine Receptor. 120126 high mobility group 120127 Domain in SPla and the RYanodine Receptor. 120128 Domain in SPla and the RYanodine Receptor. 120144 high mobility group 120145 Domain in SPla and the RYanodine Receptor. 120146 Domain in SPla and the RYanodine Receptor. 120237 Homeodomain 120332 Caspase recruitment domain 120332 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 120364 RNA recognition motif 120425 Immunoglobulin V-Type 120526 DnaJ molecular chaperone homology domain 120718 14-3-3 homologues 120824 Ring finger 120829 Domain in SPla and the RYanodine Receptor. 120863 Domain found in Dishevelled, Egl-10, and Pleckstrin 120892 Rab subfamily of small GTPases 120892 Ras subfamily of RAS small GTPases 120892 Tyrosine kinase, catalytic domain 120892 Serine/Threonine protein kinases, catalytic domain 120892 Rho (Ras homology) subfamily of Ras-like small GTPases 120892 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 120940 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 121021 Laminin G domain 121216 P or trefoil or TFF domain 121227 Immunoglobulin 121268 Ras subfamily of RAS small GTPases 121274 krueppel associated box 121481 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 121504 Histone H4 121512 Protein present in Fab1, YOTB, Vac1, and EEA1 121512 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 121549 helix loop helix domain 121599 erythroblast transformation specific domain 121916 EF-hand, calcium binding motif 121940 ARF-like small GTPases 121940 Rab subfamily of small GTPases 121940 Rho (Ras homology) subfamily of Ras-like small GTPases 121940 Sar1p-like members of the Ras-family of small GTPases 121940 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 122013 DEAD-like helicases superfamily 122013 helicase superfamily c-terminal domain 122042 Low-density lipoprotein receptor domain class A 122134 Tyrosine kinase, catalytic domain 122134 Serine/Threonine protein kinases, catalytic domain 122201 in StAR and phosphatidylcholine transfer protein 122402 Tudor domain 122402 DEAD-like helicases superfamily 122402 helicase superfamily c-terminal domain 122500 SERine Proteinase INhibitors 122524 Kelch domain 122665 Pancreatic ribonuclease 122786 Band 4.1 homologues 122809 Src homology 2 domains 122809 suppressors of cytokine signalling 122876 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 122953 basic region leucin zipper 123103 Kelch domain 123103 Broad-Complex, Tramtrack and Bric a brac 123257 domain in high mobilty group proteins HMG14 and HMG 17 123374 Histone H3 123722 Fibronectin type 3 domain 123722 Domain in SPla and the RYanodine Receptor. 123788 Trypsin-like serine protease 124056 Src homology 3 domains 124056 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 124149 ankyrin repeats 124221 Trypsin-like serine protease 124221 Trypsin-like serine protease 124245 zinc finger 124359 Chromatin organization modifier domain 124401 ankyrin repeats 124401 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 124411 krueppel associated box 124461 Src homology 3 domains 124497 Homeodomain 124535 heat shock factor 124555 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 124590 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 124599 Immunoglobulin 124664 krueppel associated box 124827 EF-hand, calcium binding motif 124857 Immunoglobulin 124857 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 124923 Serine/Threonine protein kinases, catalytic domain 124925 Domain abundant in complement control proteins 124925 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 124925 Domain abundant in complement control proteins 124925 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 125058 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 125058 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 125306 krueppel associated box 125491 Rho (Ras homology) subfamily of Ras-like small GTPases 125877 Immunoglobulin 125877 Immunoglobulin C-2 Type 125884 krueppel associated box 125919 krueppel associated box 125931 Immunoglobulin 125931 Immunoglobulin C-2 Type 125950 RNA recognition motif 126005 Ubiquitin homologues 126006 LGN motif, putative GEFs specific for G-alpha GTPases 126014 Immunoglobulin 126014 Immunoglobulin 126014 Immunoglobulin 126015 Homeodomain 126060 RNA recognition motif 126147 Netrin C-terminal Domain 126259 Immunoglobulin 126326 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 126374 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 126432 Domain present in VPS9 126494 krueppel associated box 126504 krueppel associated box 126520 Serine/Threonine protein kinases, catalytic domain 126567 Protein kinase C conserved region 2 (CalB) 126669 Src homology 2 domains 126755 Leucine rich repeat C-terminal domain 126860 Rab subfamily of small GTPases 126860 Ras subfamily of RAS small GTPases 126860 Putative GTP-ase activating proteins for the small GTPase, ARF 126860 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 126905 Domain abundant in complement control proteins 126961 Histone H3 127096 RNA recognition motif 127150 Pentraxin / C-reactive protein / pentaxin family 127294 Immunoglobulin 127428 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 127540 high mobility group 127544 In Between Ring fingers 127733 Domain present in ubiquitin-regulatory proteins 127779 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 127784 DnaJ molecular chaperone homology domain 127833 Protein kinase C conserved region 2 (CalB) 127850 Chromo Shadow Domain 127884 Calponin homology domain 127933 RNA recognition motif 128239 GTPase-activator protein for Ras-like GTPases 128239 GTPase-activator protein for Ras-like GTPases 128248 Immunoglobulin 128272 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 128312 Histone H2B 128340 Glyco_18 domain 128341 Glyco_18 domain 128345 Glyco_18 domain 128345 Chitin-binding domain type 2 128434 Immunoglobulin 128637 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 128646 Immunoglobulin 128646 Immunoglobulin 128646 Immunoglobulin V-Type 128753 krueppel associated box 128817 Cystatin-like domain 128821 Cystatin-like domain 128853 Dual specificity phosphatase, catalytic domain 128853 Dual specificity phosphatase, catalytic domain 128859 BPI/LBP/CETP C-terminal domain 128859 BPI/LBP/CETP N-terminal domain 129049 domain involved in Ras-like GTPase signaling 129081 associated with SPRY domains 129081 Domain in SPla and the RYanodine Receptor. 129316 Actin depolymerisation factor/cofilin -like domains 129402 Cold shock protein domain 129486 helicase superfamily c-terminal domain 129499 high mobility group 129522 GTPase-activator protein for Rho-like GTPases 129602 Phosphoinositide 3-kinase, catalytic domain 129684 Laminin G domain 129684 Laminin G domain 129685 Bromodomain transcription factors and PHD domain containing proteins 129804 Calcium-binding EGF-like domain 129804 Domain abundant in complement control proteins 129831 RNA recognition motif 129868 Ring finger 129868 B-Box C-terminal domain 129870 high mobility group 129880 Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc 130120 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 130271 Band 4.1 homologues 130271 Domain in Myosin and Kinesin Tails 130271 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 130399 GS motif 130500 CDGSH-type zinc finger. Function unknown 130502 Tetratricopeptide repeats 130576 Ly-6 antigen / uPA receptor -like domain 130633 Ring finger 130633 B-Box C-terminal domain 130633 Domain in SPla and the RYanodine Receptor. 130749 Zn_pept domain 131034 von Willebrand factor (vWF) type A domain 131096 Cyclic nucleotide-monophosphate binding domain 131149 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 131185 Ubiquitin homologues 131185 Ubiquitin associated domain 131368 Zona pellucida (ZP) domain 131405 B-Box-type zinc finger 131405 B-Box C-terminal domain 131405 Filamin-type immunoglobulin domains 131523 Actin depolymerisation factor/cofilin -like domains 131566 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 131583 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 131873 von Willebrand factor (vWF) type A domain 131880 krueppel associated box 131890 Regulator of G protein signalling domain 131890 Serine/Threonine protein kinases, catalytic domain 132160 Serine/threonine phosphatases, family 2C, catalytic domain 132187 Tyrosine kinase, catalytic domain 132187 Serine/Threonine protein kinases, catalytic domain 132369 Domain in the RNA-binding Lupus La protein 132430 RNA recognition motif 132604 Ricin-type beta-trefoil 132612 Double-stranded RNA binding motif 132689 Ring finger 132689 associated with SPRY domains 132689 Domain in SPla and the RYanodine Receptor. 132722 Trypsin-like serine protease 132724 Trypsin-like serine protease 132724 Trypsin-like serine protease 132724 Domain found in sea urchin sperm protein, enterokinase, agrin 132864 RNA recognition motif 132864 RNA recognition motif 132864 RNA recognition motif 132946 ARF-like small GTPases 132946 Sar1p-like members of the Ras-family of small GTPases 133022 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 133214 krueppel associated box 133277 BAR domain 133277 Src homology 3 domains 133277 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 133332 ARF-like small GTPases 133384 Transforming growth factor-beta (TGF-beta) family 133396 Fibronectin type 3 domain 133418 Immunoglobulin 133522 RNA recognition motif 133539 domain present in cyclins, TFIIB and Retinoblastoma 133584 Laminin G domain 133584 Fibronectin type 3 domain 133584 Laminin G domain 133584 Laminin G domain 133584 Laminin G domain 133628 Suppressor-of-White-APricot splicing regulator 133730 RNA recognition motif 133789 Rab subfamily of small GTPases 133789 Ras subfamily of RAS small GTPases 134111 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 134187 Found in Pit-Oct-Unc transcription factors 134218 U1-like zinc finger 134265 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 134356 BAR domain 134469 domain involved in Ras-like GTPase signaling 134502 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 134502 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 134510 Ubiquitin homologues 134510 catalytic domain of ctd-like phosphatases 134526 in StAR and phosphatidylcholine transfer protein 134611 RNA recognition motif 134725 prohibitin homologues 134829 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 134897 Src homology 2 domains 134897 Protein tyrosine phosphatase, catalytic domain 134897 Protein tyrosine phosphatase, catalytic domain motif 135112 domain in TBC and LysM domain containing proteins 135112 Lysin motif 135112 domain in TBC and LysM domain containing proteins 135257 prohibitin homologues 135270 JAB/MPN domain 135295 RNA recognition motif 135892 B-Box C-terminal domain 135892 associated with SPRY domains 135892 Domain in SPla and the RYanodine Receptor. 135892 Ring finger 135892 B-Box C-terminal domain 135892 Modified RING finger domain 135892 associated with SPRY domains 135892 Domain in SPla and the RYanodine Receptor. 135905 krueppel associated box 135935 Homeodomain 136051 krueppel associated box 136242 Trypsin-like serine protease 136332 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 136853 Scavenger receptor Cys-rich 137202 Phospholipase A2 137207 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 137814 Homeodomain 137839 Tyrosine kinase, catalytic domain 137839 Serine/Threonine protein kinases, catalytic domain 137886 Domain present in ubiquitin-regulatory proteins 137886 Domain of unknown function present in FAF1 (Fas-associated factor 1) 137964 Phosphate acyltransferases 137964 Phosphate acyltransferases 137970 Immunoglobulin C-2 Type 137970 Thrombospondin type 1 repeats 137970 Domain present in ZO-1 and Unc5-like netrin receptors 137970 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 138046 RNA recognition motif 138198 prohibitin homologues 138319 Papain family cysteine protease 138429 Phosphatidylinositol phosphate kinases 138474 bromo domain 138562 14-3-3 homologues 138652 Trypsin-like serine protease 138715 ARID (A/T-rich interaction domain) domain 138874 Domain in the RNA-binding Lupus La protein 138925 Furin-like repeats 138926 Furin-like repeats 138929 Furin-like repeats 138961 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 139084 RNA recognition motif 139125 Rab subfamily of small GTPases 139125 Ras subfamily of RAS small GTPases 139125 Rho (Ras homology) subfamily of Ras-like small GTPases 139125 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 139135 PAS domain 139170 WD40 repeats 139189 Diacylglycerol kinase accessory domain (presumed) 139189 Diacylglycerol kinase catalytic domain (presumed) 139189 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 139189 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 139193 high mobility group 139216 SERine Proteinase INhibitors 139226 prohibitin homologues 139263 Zinc finger domain 139272 RNA recognition motif 139282 14-3-3 homologues 139284 Src homology 2 domains 139284 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 139306 high mobility group 139309 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen 139334 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 139378 Pentraxin / C-reactive protein / pentaxin family 139378 G-protein-coupled receptor proteolytic site domain 139390 Cyclic nucleotide-monophosphate binding domain 139425 WD40 repeats 139433 RNA recognition motif 139628 FORKHEAD 139707 FORKHEAD 139716 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 139728 Tyrosine kinase, catalytic domain 139728 Serine/Threonine protein kinases, catalytic domain 139735 krueppel associated box 139914 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 139932 DEAD-like helicases superfamily 139952 Serine/Threonine protein kinases, catalytic domain 139952 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 140036 RNA recognition motif 140038 Trypsin-like serine protease 140065 RNA recognition motif 140100 RNA recognition motif 140101 RNA recognition motif 140123 RNA recognition motif 140127 Rab subfamily of small GTPases 140129 Chromatin organization modifier domain 140149 Chromatin organization modifier domain 140164 Domain associated with PX domains 140447 Domains in Na-Ca exchangers and integrin-beta4 140453 Domain found in sea urchin sperm protein, enterokinase, agrin 140456 suppressors of cytokine signalling 140459 suppressors of cytokine signalling 140469 Myosin. Large ATPases. ATPase 140469 Serine/Threonine protein kinases, catalytic domain 140474 von Willebrand factor (vWF) type D domain 140474 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 140486 RNA recognition motif 140486 K homology RNA-binding domain 140488 RNA recognition motif 140488 K homology RNA-binding domain 140497 Immunoglobulin 140497 Immunoglobulin 140498 Low-density lipoprotein receptor domain class A 140500 Putative GTP-ase activating proteins for the small GTPase, ARF 140500 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 140545 Ring finger 140559 Immunoglobulin 140570 GTPase-activator protein for Ras-like GTPases 140571 semaphorin domain 140571 GTPase-activator protein for Ras-like GTPases 140571 domain found in Plexins, Semaphorins and Integrins 140583 Serine/Threonine protein kinases, catalytic domain 140584 found in Wnt-1 140585 Tyrosine kinase, catalytic domain 140585 Serine/Threonine protein kinases, catalytic domain 140586 high mobility group 140592 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 140607 Phosphatidylinositol phosphate kinases 140609 Serine/Threonine protein kinases, catalytic domain 140610 membrane-attack complex / perforin 140612 krueppel associated box 140628 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 140629 Modified RING finger domain 140657 UAS domain 140657 Domain present in ubiquitin-regulatory proteins 140665 Rab subfamily of small GTPases 140671 Serine/Threonine protein kinases, catalytic domain 140689 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 140691 associated with SPRY domains 140691 Domain in SPla and the RYanodine Receptor. 140693 Phospholipase C, catalytic domain (part) 140693 Phospholipase C, catalytic domain (part) 140693 Protein kinase C conserved region 2 (CalB) 140706 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 140722 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 140731 Ubiquitin homologues 140740 Domain of unknown function in Sec63p, Brr2p and other proteins 140743 Ras subfamily of RAS small GTPases 140765 Scavenger receptor Cys-rich 140765 Trypsin-like serine protease 140766 Thrombospondin type 1 repeats 140766 Thrombospondin type 1 repeats 140780 Serine/Threonine protein kinases, catalytic domain 140792 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 140825 domain in neuralized proteins 140859 Serine/Threonine protein kinases, catalytic domain 140880 Cystatin-like domain 140885 Immunoglobulin 140885 Immunoglobulin C-Type 140886 RNA recognition motif 140887 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 140888 PAS domain 140888 Serine/Threonine protein kinases, catalytic domain 140890 RNA recognition motif 140898 Src homology 3 domains 140901 Serine/Threonine protein kinases, catalytic domain 140908 Serine/Threonine protein kinases, catalytic domain 140914 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 140924 Fibronectin type 3 domain 140928 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 140931 RNA recognition motif 140939 Ring finger 140939 B-Box C-terminal domain 140940 ARF-like small GTPases 142682 zinc finger 142683 Fibrinogen-related domains (FReDs) 142684 Rab subfamily of small GTPases 142685 suppressors of cytokine signalling 142686 suppressors of cytokine signalling 142687 suppressors of cytokine signalling 142688 suppressors of cytokine signalling 142688 suppressors of cytokine signalling 142850 Ribosomal protein L11/L12 142901 Phosphatidylinositol phosphate kinases 142980 Leucine rich repeat C-terminal domain 143098 Src homology 3 domains 143098 domain in receptor targeting proteins Lin-2 and Lin-7 143098 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 143098 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 143158 ankyrin repeats 143158 Putative GTP-ase activating proteins for the small GTPase, ARF 143158 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 143162 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 143339 Homeodomain 143458 Low-density lipoprotein receptor domain class A 143543 RNA recognition motif 143630 Ubiquitin homologues 143828 DnaJ molecular chaperone homology domain 143903 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 144165 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 144253 DEAD-like helicases superfamily 144321 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 144402 von Willebrand factor (vWF) type A domain 144406 WD40 repeats 144983 RNA recognition motif 145288 Ribosomal protein L11/L12 145371 ARF-like small GTPases 145371 Rab subfamily of small GTPases 145371 Ras subfamily of RAS small GTPases 145371 Rho (Ras homology) subfamily of Ras-like small GTPases 145371 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 145501 Thrombospondin type 1 repeats 145501 Thrombospondin type 1 repeats 145501 Adhesion-associated domain present in MUC4 and other proteins 145581 Immunoglobulin 145790 Protein kinase C conserved region 2 (CalB) 145864 Immunoglobulin 145864 Link (Hyaluronan-binding) 145990 RNA recognition motif 146177 von Willebrand factor (vWF) type A domain 146198 krueppel associated box 146540 krueppel associated box 146542 krueppel associated box 146547 Trypsin-like serine protease 146656 Plectin repeat 146691 Domain present in VPS-27, Hrs and STAM 146760 Leucine rich repeat C-terminal domain 146894 Immunoglobulin 146923 domain involved in Ras-like GTPase signaling 147040 Broad-Complex, Tramtrack and Bric a brac 147072 basic region leucin zipper 147123 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 147166 associated with SPRY domains 147166 Domain in SPla and the RYanodine Receptor. 147372 Calcium-binding EGF-like domain 147381 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 147381 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 147398 RNA recognition motif 147400 RNA recognition motif 147409 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 147650 Immunoglobulin 147657 krueppel associated box 147658 krueppel associated box 147658 krueppel associated box 147686 krueppel associated box 147699 Serine/threonine phosphatases, family 2C, catalytic domain 147699 Serine/threonine phosphatases, family 2C, catalytic domain 147740 Netrin C-terminal Domain 147741 krueppel associated box 147742 krueppel associated box 147746 Serine/Threonine protein kinases, catalytic domain 147929 krueppel associated box 147948 krueppel associated box 147949 krueppel associated box 148003 Galectin 148022 Toll - interleukin 1 - resistance 148064 snRNP Sm proteins 148066 Ring finger 148103 krueppel associated box 148113 Immunoglobulin 148156 krueppel associated box 148198 krueppel associated box 148203 krueppel associated box 148206 krueppel associated box 148224 K homology RNA-binding domain 148252 Ras subfamily of RAS small GTPases 148268 krueppel associated box 148281 Protein kinase C conserved region 2 (CalB) 148327 basic region leucin zipper 148398 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 148534 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 148646 B-Box C-terminal domain 148713 Protein tyrosine phosphatase, catalytic domain 148713 Protein tyrosine phosphatase, catalytic domain motif 148864 Homeodomain 148864 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 149041 zinc finger 149329 Ubiquitin homologues 149371 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 149420 Serine/Threonine protein kinases, catalytic domain 149428 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 149620 Glyco_18 domain 149620 Chitin-binding domain type 2 149767 high mobility group 149954 BPI/LBP/CETP C-terminal domain 149954 BPI/LBP/CETP N-terminal domain 150084 Immunoglobulin 150094 Serine/Threonine protein kinases, catalytic domain 150221 Src homology 3 domains 150221 Fibronectin type 3 domain 150287 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 150290 Dual specificity phosphatase, catalytic domain 150350 Epsin N-terminal homology (ENTH) domain 150356 Leucine rich repeat C-terminal domain 150498 14-3-3 homologues 150572 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 150739 Modified RING finger domain 150868 Ribosomal protein L11/L12 150940 WD40 repeats 150969 RNA recognition motif 151126 U1-like zinc finger 151127 U1-like zinc finger 151290 Immunoglobulin 151290 Immunoglobulin C-2 Type 151320 high mobility group 151449 Transforming growth factor-beta (TGF-beta) family 151556 Domain found in Dishevelled, Egl-10, and Pleckstrin 151561 Histone H3 151579 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 151636 Ring finger 151649 Serine/threonine phosphatases, family 2C, catalytic domain 151723 Homeodomain 151742 Serine/threonine phosphatases, family 2C, catalytic domain 151790 WD40 repeats 151835 von Willebrand factor (vWF) type A domain 151888 Immunoglobulin 152007 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 152015 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 152059 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 152101 Homeodomain 152110 Serine/Threonine protein kinases, catalytic domain 152273 Protein present in Fab1, YOTB, Vac1, and EEA1 152273 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 152273 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 152330 Immunoglobulin 152330 Immunoglobulin C-2 Type 152330 Immunoglobulin 152404 Immunoglobulin 152503 Src homology 3 domains 152687 krueppel associated box 152815 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 152829 WD40 repeats 152926 Serine/threonine phosphatases, family 2C, catalytic domain 153020 Guanine nucleotide exchange factor for Ras-like GTPases 153020 Guanine nucleotide exchange factor for Ras-like small GTPases 153027 RRM_1 domain 153027 RNA recognition motif 153090 Protein kinase C conserved region 2 (CalB) 153090 GTPase-activator protein for Ras-like GTPases 153217 Kazal type serine protease inhibitors 153218 Kazal type serine protease inhibitors 153527 U1-like zinc finger 153579 Immunoglobulin 153703 Histone H2B 153769 Ring finger 153769 Src homology 3 domains 153817 RNA recognition motif 154043 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 154043 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 154075 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 154214 In Between Ring fingers 154337 Ubiquitin homologues 154849 14-3-3 homologues 154865 Ubiquitin homologues 154982 Serine/Threonine protein kinases, catalytic domain 155012 Domain abundant in complement control proteins 155051 Beta/gamma crystallins 155054 krueppel associated box 155183 Src homology 3 domains 155183 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 155696 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 155812 B-Box-type zinc finger 155812 B-Box C-terminal domain 155918 Src homology 2 domains 155918 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 156117 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 156435 Scavenger receptor Cys-rich 156435 Trypsin-like serine protease 157285 Tyrosine kinase, catalytic domain 157285 Serine/Threonine protein kinases, catalytic domain 157295 Defensin/corticostatin family 157589 Broad-Complex, Tramtrack and Bric a brac 157667 EF-hand, calcium binding motif 157793 Actin depolymerisation factor/cofilin -like domains 158038 Immunoglobulin 158038 Leucine rich repeat C-terminal domain 158056 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 158125 WD40 repeats 158237 Broad-Complex, Tramtrack and Bric a brac 158284 Tyrosine kinase, catalytic domain 158284 Serine/Threonine protein kinases, catalytic domain 158326 Domains in Na-Ca exchangers and integrin-beta4 158352 snRNP Sm proteins 158381 A20-like zinc fingers 158399 leucine rich region 158399 krueppel associated box 158624 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 158668 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 158747 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 158763 GTPase-activator protein for Rho-like GTPases 158777 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 158943 Ran-binding domain 158983 Histone H2B 158997 Ubiquitin homologues 159162 RNA recognition motif 159163 RNA recognition motif 159184 ankyrin repeats 159815 helicase superfamily c-terminal domain 160364 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 160365 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 160418 Tetratricopeptide repeats 160518 domain involved in Ras-like GTPase signaling 160622 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 160622 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 160851 Diacylglycerol kinase accessory domain (presumed) 160851 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 160851 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 160851 Diacylglycerol kinase accessory domain (presumed) 160851 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 160851 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 160851 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 161356 Immunoglobulin 161356 Immunoglobulin C-2 Type 161357 Immunoglobulin 161357 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 161357 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 161514 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 161742 WASP homology region 1 161829 3'-5' exonuclease 161931 Double-stranded RNA binding motif 161931 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 162699 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 162835 Leucine rich repeat C-terminal domain 162952 Immunoglobulin 162952 Immunoglobulin C-2 Type 162962 krueppel associated box 162963 krueppel associated box 162968 leucine rich region 162972 krueppel associated box 162993 krueppel associated box 163081 krueppel associated box 163087 krueppel associated box 163227 krueppel associated box 163233 krueppel associated box 163255 krueppel associated box 163404 Acid phosphatase homologues 163933 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 164036 Regulator of G protein signalling domain 164045 DEAD-like helicases superfamily 164153 Ubiquitin homologues 164312 Fibronectin type 3 domain 164558 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 164633 EF-hand, calcium binding motif 164656 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 164656 Trypsin-like serine protease 164656 Low-density lipoprotein receptor domain class A 164656 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 164781 WD40 repeats 164832 Ring finger 164964 Histone H3 165082 G-protein-coupled receptor proteolytic site domain 165257 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 165257 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 165324 Domain of unknown function present in FAF1 (Fas-associated factor 1) 165324 Domain present in ubiquitin-regulatory proteins 165324 Domain of unknown function present in FAF1 (Fas-associated factor 1) 165530 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 165918 Ring finger 166336 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 166348 Kelch domain 166348 Broad-Complex, Tramtrack and Bric a brac 166522 Src homology 2 domains 166614 Domain in the Doublecortin (DCX) gene product 166614 Serine/Threonine protein kinases, catalytic domain 166647 Immunoglobulin 166647 G-protein-coupled receptor proteolytic site domain 166655 Ring finger 166655 associated with SPRY domains 166655 Domain in SPla and the RYanodine Receptor. 166657 Ring finger 166657 associated with SPRY domains 166657 Domain in SPla and the RYanodine Receptor. 166752 Domains in Na-Ca exchangers and integrin-beta4 166815 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 166824 Ras association (RalGDS/AF-6) domain 166863 RNA recognition motif 166867 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 166968 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 166974 ankyrin repeats 167359 Serine/Threonine protein kinases, catalytic domain 168374 krueppel associated box 168400 K homology RNA-binding domain 168417 krueppel associated box 168667 von Willebrand factor (vWF) type C domain 168667 von Willebrand factor (vWF) type D domain 169044 von Willebrand factor (vWF) type A domain 169044 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 169166 Band 4.1 homologues 169270 krueppel associated box 169436 Tyrosine kinase, catalytic domain 169436 Serine/Threonine protein kinases, catalytic domain 169611 Olfactomedin-like domains 169831 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 169841 krueppel associated box 170082 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 170459 in StAR and phosphatidylcholine transfer protein 170463 Lissencephaly type-1-like homology motif 170482 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 170483 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 170501 Ricin-type beta-trefoil 170538 Serine/Threonine protein kinases, catalytic domain 170568 Scavenger receptor Cys-rich 170568 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 170570 in StAR and phosphatidylcholine transfer protein 170571 Laminin G domain 170571 Fibrinogen-related domains (FReDs) 170577 Ubiquitin associated domain 170577 Serine/Threonine protein kinases, catalytic domain 170579 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 170580 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 170582 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 170583 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 170625 Src homology 3 domains 170630 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 170632 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 170637 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 170641 Olfactomedin-like domains 170641 Domain present in hormone receptors 170643 Immunoglobulin 170643 Immunoglobulin C-2 Type 170668 Guanine nucleotide exchange factor for Ras-like GTPases 170668 Guanine nucleotide exchange factor for Ras-like small GTPases 170672 prohibitin homologues 170677 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 170689 ADAM Cysteine-Rich Domain 170689 Thrombospondin type 1 repeats 170690 Thrombospondin type 1 repeats 170691 Thrombospondin type 1 repeats 170692 Thrombospondin type 1 repeats 170719 domain in TBC and LysM domain containing proteins 170720 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 170721 Immunoglobulin 170721 Thrombospondin type 1 repeats 170721 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 170721 Immunoglobulin 170721 Immunoglobulin C-2 Type 170721 Thrombospondin type 1 repeats 170721 BPTI/Kunitz family of serine protease inhibitors 170721 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 170733 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 170738 Cyclic nucleotide-monophosphate binding domain 170738 Cyclic nucleotide-monophosphate binding domain 170738 Cyclic nucleotide-monophosphate binding domain 170739 Cyclic nucleotide-monophosphate binding domain 170740 leucine rich region 170740 krueppel associated box 170749 Protein present in Fab1, YOTB, Vac1, and EEA1 170749 Protein tyrosine phosphatase, catalytic domain motif 170755 Serine/Threonine protein kinases, catalytic domain 170755 Serine/Threonine protein kinases, catalytic domain 170757 Calcium-binding EGF-like domain 170758 Rho (Ras homology) subfamily of Ras-like small GTPases 170761 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 170763 krueppel associated box 170786 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 170788 Laminin G domain 170791 RNA recognition motif 170796 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 170820 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 170822 Domain in ubiquitin-specific proteases 170826 RNA recognition motif 170835 Inositol polyphosphate phosphatase, catalytic domain homologues 170837 Serine/Threonine protein kinases, catalytic domain 170851 Serine/Threonine protein kinases, catalytic domain 170895 EF-hand, calcium binding motif 170903 PAS domain 170904 Serine/Threonine protein kinases, catalytic domain 170911 PI3-kinase family, Ras-binding domain 170911 Phosphoinositide 3-kinase, catalytic domain 170911 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 170911 Phosphoinositide 3-kinase, region postulated to contain C2 domain 170912 RNA recognition motif 170915 TAZ zinc finger, present in p300 and CBP 170919 Phosphate acyltransferases 170920 Tyrosine kinase, catalytic domain 170920 Serine/Threonine protein kinases, catalytic domain 170920 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 170923 Ras subfamily of RAS small GTPases 170935 Formin Homology 2 Domain 170935 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 170936 krueppel associated box 170936 zinc finger 170936 leucine rich region 170936 krueppel associated box 170946 RNA recognition motif 170955 leucine rich region 170955 krueppel associated box 170959 krueppel associated box 170959 krueppel associated box 170961 ankyrin repeats 171016 Cystatin-like domain 171019 Thrombospondin type 1 repeats 171024 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 171045 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 171052 Zinc-dependent metalloprotease 171052 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 171055 Immunoglobulin 171059 Four-disulfide core domains 171064 Immunoglobulin V-Type 171068 Homeodomain 171068 Found in Pit-Oct-Unc transcription factors 171070 Band 4.1 homologues 171070 Protein tyrosine phosphatase, catalytic domain 171075 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 171088 Inositol polyphosphate phosphatase, catalytic domain homologues 171091 Z-DNA-binding domain in adenosine deaminases. Helix-turn-helix-containing domain. Also known as Zab 171092 RNA recognition motif 171093 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 171093 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 171096 Cystatin-like domain 171097 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 171099 Ras subfamily of RAS small GTPases 171100 Fibrinogen-related domains (FReDs) 171106 Immunoglobulin 171106 Immunoglobulin C-2 Type 171109 Rhodanese Homology Domain 171111 Rab subfamily of small GTPases 171112 Four-disulfide core domains 171115 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 171119 Immunoglobulin 171119 Immunoglobulin C-2 Type 171121 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 171122 Rab subfamily of small GTPases 171125 Protein tyrosine phosphatase, catalytic domain 171136 Ring finger 171136 Ubiquitin associated domain 171137 K homology RNA-binding domain 171140 Serine/Threonine protein kinases, catalytic domain 171159 Homeodomain 171160 Homeodomain 171171 Laminin N-terminal domain (domain VI) 171171 Laminin-type epidermal growth factor-like domai 171177 Rho (Ras homology) subfamily of Ras-like small GTPases 171207 Src homology 3 domains 171207 GTPase-activator protein for Rho-like GTPases 171212 Ricin-type beta-trefoil 171283 Immunoglobulin V-Type 171284 Immunoglobulin 171285 Immunoglobulin V-Type 171287 Fibronectin type 3 domain 171287 Tyrosine kinase, catalytic domain 171287 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 171290 Trypsin-like serine protease 171291 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 171296 Myosin. Large ATPases. ATPase 171296 Ras association (RalGDS/AF-6) domain 171296 GTPase-activator protein for Rho-like GTPases 171299 FORKHEAD 171305 Serine/Threonine protein kinases, catalytic domain 171333 Fibronectin type 3 domain 171337 Ras subfamily of RAS small GTPases 171355 Homeodomain 171355 Found in Pit-Oct-Unc transcription factors 171357 Fibronectin type 3 domain 171357 Protein tyrosine phosphatase, catalytic domain 171357 Dual specificity phosphatase, catalytic domain 171357 Protein tyrosine phosphatase, catalytic domain 171357 Protein tyrosine phosphatase, catalytic domain motif 171358 Serine/Threonine protein kinases, catalytic domain 171360 Homeodomain 171362 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 171362 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 171365 snRNP Sm proteins 171366 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 171371 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 171381 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 171387 associated with SPRY domains 171387 Domain in SPla and the RYanodine Receptor. 171388 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 171392 krueppel associated box 171393 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 171394 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 171399 Spectrin repeats 171434 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 171436 Profilin 171437 c4 zinc finger in nuclear hormone receptors 171447 Olfactomedin-like domains 171447 Domain present in hormone receptors 171495 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 171497 Tyrosine kinase, catalytic domain 171497 Extension to Ser/Thr-type protein kinases 171497 Serine/Threonine protein kinases, catalytic domain 171499 Fibronectin type 3 domain 171500 Double-stranded RNA binding motif 171501 Ring finger 171503 Serine/Threonine protein kinases, catalytic domain 171519 calcitonin 171528 Trypsin-like serine protease 171547 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 171551 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 171552 Splicing Factor Motif, present in Prp18 and Pr04 171554 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 171566 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 171566 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 171567 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 171567 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 171567 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 171567 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 171571 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 171581 Rho (Ras homology) subfamily of Ras-like small GTPases 191571 Laminin G domain 191571 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 191578 DEAD-like helicases superfamily 191578 helicase superfamily c-terminal domain 191595 Protein kinase C conserved region 2 (CalB) 192107 Trypsin-like serine protease 192109 Found in Pit-Oct-Unc transcription factors 192110 Found in Pit-Oct-Unc transcription factors 192117 Protein kinase C conserved region 2 (CalB) 192117 GTPase-activator protein for Ras-like GTPases 192117 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 192117 Protein kinase C conserved region 2 (CalB) 192117 GTPase-activator protein for Ras-like GTPases 192117 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 192119 Ribonuclease III family 192119 Ribonuclease III family 192119 DEAD-like helicases superfamily 192119 helicase superfamily c-terminal domain 192120 associated with SPRY domains 192120 Domain in SPla and the RYanodine Receptor. 192126 Protein kinase C conserved region 2 (CalB) 192126 GTPase-activator protein for Ras-like GTPases 192154 I/LWEQ domain 192157 Src homology 2 domains 192157 suppressors of cytokine signalling 192161 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 192163 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 192164 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 192176 Filamin-type immunoglobulin domains 192176 Filamin-type immunoglobulin domains 192178 RNA recognition motif 192187 Link (Hyaluronan-binding) 192187 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 192188 Link (Hyaluronan-binding) 192188 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 192188 Link (Hyaluronan-binding) 192188 Laminin-type epidermal growth factor-like domai 192188 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 192189 Protein kinase C conserved region 2 (CalB) 192194 Immunoglobulin V-Type 192195 bromo domain 192198 Immunoglobulin 192204 Eps15 homology domain 192207 Domain of unknown function present in FAF1 (Fas-associated factor 1) 192210 U1-like zinc finger 192248 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 192249 Eps15 homology domain 192253 Myosin. Large ATPases. ATPase 192254 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 192262 Trypsin-like serine protease 192262 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 192264 Pancreatic ribonuclease 192270 Acid phosphatase homologues 192271 ADAM Cysteine-Rich Domain 192271 Homologues of snake disintegrins 192274 FORKHEAD 192292 Serine/Threonine protein kinases, catalytic domain 192348 Src homology 3 domains 192350 Serine/Threonine protein kinases, catalytic domain 192658 associated with SPRY domains 192658 Domain in SPla and the RYanodine Receptor. 192786 Guanine nucleotide exchange factor for Ras-like small GTPases 192797 Ubiquitin homologues 192852 Leucine-rich repeats, typical (most populated) subfamily 192882 Src homology 3 domains 192882 Guanylate kinase homologues 192882 Domain present in PSD-95, Dlg, and ZO-1/2 192882 domain in receptor targeting proteins Lin-2 and Lin-7 192882 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 192882 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 192897 Fibronectin type 3 domain 192897 Domains in Na-Ca exchangers and integrin-beta4 192897 Integrin beta subunits (N-terminal portion of extracellular region) 193028 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 193028 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 193113 DEAD-like helicases superfamily 193113 helicase superfamily c-terminal domain 193128 RNA recognition motif 193237 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 193237 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 193296 Tyrosine kinase, catalytic domain 193296 erine/Threonine protein kinases, catalytic domain 193296 Serine/Threonine protein kinases, catalytic domain 193330 eukaryotic translation initiation factor 1A 193357 Immunoglobulin C-Type 193360 Immunoglobulin 193360 Immunoglobulin V-Type 193361 Immunoglobulin 193361 Immunoglobulin V-Type 193362 Immunoglobulin V-Type 193383 SERine Proteinase INhibitors 193403 SERine Proteinase INhibitors 193408 Histone 2A 193418 Histone H3 193431 SERine Proteinase INhibitors 193433 SERine Proteinase INhibitors 193445 Histone 2A 193449 Histone H2B 193450 Histone H2B 193454 Histone 2A 193455 Histone H2B 193510 Histone H4 193525 SERine Proteinase INhibitors 193543 Immunoglobulin 193543 Immunoglobulin V-Type 193545 Immunoglobulin 193545 Immunoglobulin V-Type 193546 Immunoglobulin 193546 Immunoglobulin V-Type 193548 Immunoglobulin 193548 Immunoglobulin V-Type 193556 Immunoglobulin 193556 Immunoglobulin V-Type 193564 Immunoglobulin 193564 Immunoglobulin V-Type 193565 Immunoglobulin 193565 Immunoglobulin V-Type 193570 Immunoglobulin 193570 Immunoglobulin V-Type 193573 Immunoglobulin 193573 Immunoglobulin V-Type 193574 Immunoglobulin 193574 Immunoglobulin V-Type 193576 Immunoglobulin 193576 Immunoglobulin V-Type 193576 Immunoglobulin C-2 Type 193582 Immunoglobulin 193582 Immunoglobulin V-Type 193587 Immunoglobulin 193587 Immunoglobulin V-Type 193588 Immunoglobulin 193588 Immunoglobulin V-Type 193589 Immunoglobulin 193589 Immunoglobulin V-Type 193590 Immunoglobulin 193590 Immunoglobulin V-Type 193590 Immunoglobulin C-2 Type 193678 RNA recognition motif 193690 zinc finger 193695 Tyrosine kinase, catalytic domain 193695 erine/Threonine protein kinases, catalytic domain 193695 Serine/Threonine protein kinases, catalytic domain 193736 Broad-Complex, Tramtrack and Bric a brac 193762 Immunoglobulin C-Type 193764 Immunoglobulin C-Type 193765 Immunoglobulin C-Type 193766 Immunoglobulin C-Type 193768 Ring finger 193796 Tudor domain 193810 Tyrosine kinase, catalytic domain 193810 Serine/Threonine protein kinases, catalytic domain 194003 Phospholipase C, catalytic domain (part) 194003 Protein kinase C conserved region 2 (CalB) 194056 BPTI/Kunitz family of serine protease inhibitors 194056 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 194175 Tyrosine kinase, catalytic domain 194175 erine/Threonine protein kinases, catalytic domain 194175 Serine/Threonine protein kinases, catalytic domain 194189 helicase superfamily c-terminal domain 194245 helicase superfamily c-terminal domain 194269 helicase superfamily c-terminal domain 194357 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at presen 194358 Immunoglobulin 194360 Trypsin-like serine protease 194401 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 194508 Rab subfamily of small GTPases 194508 Ras subfamily of RAS small GTPases 194508 Rho (Ras homology) subfamily of Ras-like small GTPases 194578 Immunoglobulin 194578 Immunoglobulin V-Type 194579 Immunoglobulin 194579 Immunoglobulin V-Type 194580 Immunoglobulin 194580 Immunoglobulin V-Type 194581 Immunoglobulin 194581 Immunoglobulin V-Type 194587 Leucine rich repeat, ribonuclease inhibitor type 194588 Homeodomain 194590 Eps15 homology domain 194597 Trypsin-like serine protease 194604 SERine Proteinase INhibitors 194655 zinc finger 194735 tob/btg1 family 194736 tob/btg1 family 194737 Homeodomain 194738 Homeodomain 194740 basic region leucin zipper 194765 RNA recognition motif 194788 leucine rich region 194856 Homeodomain 194861 zinc finger 194861 glycine rich nucleic binding domain 194873 Histone H3 194895 Dual specificity phosphatase, catalytic domain 194895 Protein tyrosine phosphatase, catalytic domain 194895 Protein tyrosine phosphatase, catalytic domain motif 194908 Phospholipase D. Active site motifs 194952 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 195018 Zinc-binding domain, present in Dystrophin, CREB-binding protein 195018 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 195071 Histone H3 195084 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 195084 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 195085 Immunoglobulin 195150 eukaryotic translation initiation factor 1A 195151 eukaryotic translation initiation factor 1A 195154 RNA recognition motif 195155 zinc finger 195172 Immunoglobulin 195172 Immunoglobulin V-Type 195176 Immunoglobulin 195176 Immunoglobulin V-Type 195177 Immunoglobulin 195177 Immunoglobulin V-Type 195179 Immunoglobulin 195179 Immunoglobulin V-Type 195180 Immunoglobulin 195180 Immunoglobulin V-Type 195183 Immunoglobulin 195183 Immunoglobulin V-Type 195184 Immunoglobulin 195184 Immunoglobulin V-Type 195208 Domain in the Doublecortin (DCX) gene product 195208 Domain in the Doublecortin (DCX) gene product 195211 Histone 2A 195212 Histone H2B 195213 Histone 2A 195221 zinc finger 195228 Histone 2A 195229 Histone 2A 195230 Histone H2B 195237 Histone 2A 195252 high mobility group 195262 Histone 2A 195266 Histone 2A 195267 Histone H4 195281 Immunoglobulin 195281 Immunoglobulin V-Type 195284 Immunoglobulin 195284 Immunoglobulin V-Type 195285 Immunoglobulin 195285 Immunoglobulin V-Type 195286 Immunoglobulin 195286 Immunoglobulin V-Type 195289 Immunoglobulin 195289 Immunoglobulin V-Type 195290 Immunoglobulin 195290 Immunoglobulin V-Type 195291 Immunoglobulin 195291 Immunoglobulin V-Type 195292 Immunoglobulin 195292 Immunoglobulin V-Type 195295 Immunoglobulin 195295 Immunoglobulin V-Type 195296 Immunoglobulin 195296 Immunoglobulin V-Type 195297 Immunoglobulin 195297 Immunoglobulin V-Type 195298 Immunoglobulin 195298 Immunoglobulin V-Type 195300 Immunoglobulin 195300 Immunoglobulin V-Type 195333 Homeodomain 195333 Homeodomain 195349 Immunoglobulin 195349 Immunoglobulin V-Type 195349 Domain in SPla and the RYanodine Receptor. 195349 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 195349 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 195359 Ring finger 195489 CDGSH-type zinc finger. Function unknown 195531 krueppel associated box 195533 krueppel associated box 195534 krueppel associated box 195559 krueppel associated box 195564 Immunoglobulin V-Type 195564 Immunoglobulin 195564 Immunoglobulin V-Type 195601 Immunoglobulin 195601 Immunoglobulin V-Type 195607 Immunoglobulin V-Type 195608 Immunoglobulin 195608 Immunoglobulin V-Type 195624 ankyrin repeats 195691 high mobility group 195701 ankyrin repeats 195707 Immunoglobulin 195707 Immunoglobulin V-Type 195708 Immunoglobulin 195708 Immunoglobulin V-Type 195709 Immunoglobulin 195709 Immunoglobulin V-Type 195710 Immunoglobulin 195710 Immunoglobulin V-Type 195712 DNA-directed RNA-polymerase II subunit 195726 Sterile alpha motif 195726 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 195805 Homeodomain 195977 von Willebrand factor (vWF) type A domain 195979 Putative GTP-ase activating proteins for the small GTPase, ARF 195979 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 196051 Acid phosphatase homologues 196264 Immunoglobulin V-Type 196346 high mobility group 196348 Ring finger 196400 Protein kinase C conserved region 2 (CalB) 196403 Ring finger 196403 Ring finger 196746 Guanine nucleotide exchange factor for Ras-like small GTPases 196996 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 197097 Zn_pept domain 197259 Tyrosine kinase, catalytic domain 197320 krueppel associated box 197320 krueppel associated box 197350 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 197358 Leucine rich repeat, ribonuclease inhibitor type 199704 krueppel associated box 199718 krueppel associated box 199731 Immunoglobulin 199731 Immunoglobulin C-2 Type 199731 putative band 4.1 homologues' binding motif 199744 krueppel associated box 199745 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 199746 RRM_1 domain 199766 Immunoglobulin 199777 krueppel associated box 199783 Trypsin-like serine protease 199970 Profilin 200014 Protein kinase C conserved region 2 (CalB) 200014 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 200125 Laminin G domain 200213 U1-like zinc finger 200225 Protein kinase C conserved region 2 (CalB) 200226 RNA recognition motif 200312 Ring finger 200466 Src homology 3 domains 200504 Pulmonary surfactant proteins 200575 Beta/gamma crystallins 200576 Domain found in Dishevelled, Egl-10, and Pleckstrin 200583 RNA recognition motif 200704 zinc finger 200734 WASP homology region 1 200734 WASP homology region 1 200765 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 200933 A Receptor for Ubiquitination Targets 200933 Domain in SPla and the RYanodine Receptor. 200972 Rab subfamily of small GTPases 200972 Ras subfamily of RAS small GTPases 200972 Rho (Ras homology) subfamily of Ras-like small GTPases 200972 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 201164 Phospholipase D. Active site motifs. Phosphatidylcholine-hydrolyzing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of cert 201176 Domain with 2 conserved Trp (W) residues 201176 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 201191 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 201294 Protein kinase C conserved region 2 (CalB) 201299 RNA recognition motif 201382 Laminin N-terminal domain (domain VI) 201382 Laminin-type epidermal growth factor-like domai 201456 A Receptor for Ubiquitination Targets 201475 Rab subfamily of small GTPases 201475 Ras subfamily of RAS small GTPases 201475 Rho (Ras homology) subfamily of Ras-like small GTPases 201510 krueppel associated box 201514 krueppel associated box 201516 leucine rich region 201633 Immunoglobulin V-Type 201784 ADAM Cysteine-Rich Domain 201784 Homologues of snake disintegrins 201798 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 201929 B-Box-type zinc finger 201929 Domain in SPla and the RYanodine Receptor. 201965 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 202151 Ran-binding domain 202333 B-Box C-terminal domain 202333 Fibronectin type 3 domain 202366 Armadillo/beta-catenin-like repeats 202374 Serine/Threonine protein kinases, catalytic domain 202757 krueppel associated box 202758 krueppel associated box 203074 Trypsin-like serine protease 203100 Insulin growth factor-binding protein homologues 203102 ADAM Cysteine-Rich Domain 203102 Homologues of snake disintegrins 203112 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 203249 Broad-Complex, Tramtrack and Bric a brac 203286 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 203328 Domain abundant in complement control proteins 203447 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 203510 high mobility group 203522 von Willebrand factor (vWF) type A domain 203523 leucine rich region 203611 Chromatin organization modifier domain 203806 Fibronectin type 3 domain 203806 Ephrin receptor ligand binding domain 204219 Homeodomain 204219 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 204777 Immunoglobulin C-Type 204851 Serine/Threonine protein kinases, catalytic domain 205860 associated with SPRY domains 205860 Domain in SPla and the RYanodine Receptor. 206426 Phosphatidylinositol phosphate kinases 206938 Immunoglobulin C-2 Type 207119 Domain present in VPS9 207119 Src homology 2 domains 207165 bromo domain 207165 bromo domain 207165 PHD zinc finger 207181 RNA recognition motif 207181 RNA recognition motif 207187 krueppel associated box 207194 DEAD-like helicases superfamily 207194 Double-stranded RNA binding motif 207194 helicase superfamily c-terminal domain 207212 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 207214 Domain in the RNA-binding Lupus La protein 207278 Src homology 3 domains 207278 Fes/CIP4 homology domain 207308 Protein phosphatase 2A homologues, catalytic domain 207308 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 207350 Vault protein Inter-alpha-Trypsin domain 207350 von Willebrand factor (vWF) type A domain 207365 SERine Proteinase INhibitors 207385 zinc finger 207424 high mobility group 207474 Broad-Complex, Tramtrack and Bric a brac 207495 Src homology 3 domains 207557 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 207565 Serine/Threonine protein kinases, catalytic domain 207592 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 207596 Thrombospondin type 1 repeats 207620 helix loop helix domain 207624 high mobility group 207683 Immunoglobulin 207685 Immunoglobulin C-Type 207728 Metal dependent phosphohydrolases with conserved 'HD' motif 207728 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 207728 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 207731 krueppel associated box 207745 krueppel associated box 207777 Src homology 3 domains 207781 Protein kinase C conserved region 2 (CalB) 207787 Immunoglobulin 207787 Immunoglobulin V-Type 207795 Alkaline phosphatase homologues 207806 helix loop helix domain 207839 Ricin-type beta-trefoil 207912 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 207920 RNA recognition motif 207920 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 207950 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 207952 Kelch domain 207952 Broad-Complex, Tramtrack and Bric a brac 208043 Cysteine-rich motif following a subset of SET domains 208043 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 208076 Homeodomain 208109 Frizzled 208110 DEAD-like helicases superfamily 208110 helicase superfamily c-terminal domain 208118 DEAD-like helicases superfamily 208118 helicase superfamily c-terminal domain 208144 DEAD-like helicases superfamily 208144 helicase superfamily c-terminal domain 208144 ATPases associated with a variety of cellular activities 208154 Immunoglobulin 208154 Immunoglobulin 208166 Immunoglobulin 208166 ankyrin repeats 208166 Immunoglobulin V-Type 208169 Cyclic nucleotide-monophosphate binding domain 208171 Trypsin-like serine protease 208171 Low-density lipoprotein receptor domain class A 208171 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 208177 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 208194 DNA/RNA non-specific endonuclease 208256 Alkaline phosphatase homologues 208269 Ubiquitin homologues 208347 domain in TBC and LysM domain containing proteins 208372 suppressors of cytokine signalling 208409 Histone H3 208414 Domain in the RNA-binding Lupus La protein 208419 Tyrosine kinase, catalytic domain 208419 erine/Threonine protein kinases, catalytic domain 208419 Serine/Threonine protein kinases, catalytic domain 208427 Protein kinase C conserved region 2 (CalB) 208431 Domain present in PSD-95, Dlg, and ZO-1/2 208433 RNA recognition motif 208439 Kelch domain 208449 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 208583 Serine/Threonine protein kinases, catalytic domain 208584 Homeodomain 208642 Immunoglobulin 208642 Immunoglobulin V-Type 208647 basic region leucin zipper 208648 basic region leucin zipper 208650 Ubiquitin associated domain 208652 high mobility group 208666 Ras subfamily of RAS small GTPases 208674 Homeodomain 208677 basic region leucin zipper 208748 Domain containing Gla (gamma-carboxyglutamate) residues 208748 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 208757 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 208757 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 208824 zinc finger 208846 Formin Homology 2 Domain 208869 Src homology 3 domains 208894 ARF-like small GTPases 208894 Rab subfamily of small GTPases 208894 Sar1p-like members of the Ras-family of small GTPases 208922 RNA recognition motif 208936 Thrombospondin type 1 repeats 209039 Src homology 2 domains 209039 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 209039 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 209047 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 209091 domain present in cyclins, TFIIB and Retinoblastoma 209120 high mobility group 209131 PhoX homologous domain, present in p47phox and p40phox 209131 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 209200 Ring finger 209202 glycine rich nucleic binding domain 209224 RNA recognition motif 209230 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 209239 Kelch domain 209268 Immunoglobulin 209268 Immunoglobulin 209268 Immunoglobulin C-2 Type 209275 RNA recognition motif 209294 Cystatin-like domain 209296 RNA recognition motif 209324 Cystatin-like domain 209326 Cystatin-like domain 209334 5'-3' exonuclease 209334 Xeroderma pigmentosum G I-region 209334 Xeroderma pigmentosum G N-region 209351 WAP domain 209351 BPTI/Kunitz family of serine protease inhibitors 209351 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 209361 PHD zinc finger 209361 Bromodomain transcription factors and PHD domain containing proteins 209371 Kinesin motor, catalytic domain. ATPase 209371 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 209378 Vault protein Inter-alpha-Trypsin domain 209378 von Willebrand factor (vWF) type A domain 209384 Ring finger 209384 B-Box-type zinc finger 209384 Modified RING finger domain 209384 Domain in SPla and the RYanodine Receptor. 209387 Domain in SPla and the RYanodine Receptor. 209392 Immunoglobulin 209392 Immunoglobulin V-Type 209416 glycine rich nucleic binding domain 209416 glycine rich nucleic binding domain 209448 Homeodomain 209462 Domain Homologous to E6-AP Carboxyl Terminus with 209478 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 209488 Src homology 2 domains 209536 Kinesin motor, catalytic domain. ATPase 209536 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 209542 Dual specificity phosphatase, catalytic domain 209558 DNA/RNA non-specific endonuclease 209607 Tyrosine kinase, catalytic domain 209607 erine/Threonine protein kinases, catalytic domain 209607 Serine/Threonine protein kinases, catalytic domain 209630 Band 4.1 homologues 209637 Immunoglobulin 209637 Immunoglobulin V-Type 209673 Immunoglobulin 209673 Immunoglobulin V-Type 209737 Kinesin motor, catalytic domain. ATPase 209737 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 209768 RNA recognition motif 209791 minichromosome maintenance proteins 209815 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 209917 high mobility group 209926 Uteroglobin 209988 Immunoglobulin 209988 Immunoglobulin V-Type 210064 ankyrin repeats 210094 Immunoglobulin 210094 Immunoglobulin C-2 Type 210104 krueppel associated box 210105 krueppel associated box 210108 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 210126 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 210126 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 210126 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 210131 Immunoglobulin 210132 Immunoglobulin 210156 Immunoglobulin 210156 Immunoglobulin C-2 Type 210162 leucine rich region 210162 krueppel associated box 210197 Immunoglobulin 210197 Immunoglobulin V-Type 210208 Immunoglobulin 210208 Immunoglobulin V-Type 210274 Sterile alpha motif 210274 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 210297 Calponin homology domain 210358 Homeodomain 210363 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 210381 Tyrosine kinase, catalytic domain 210381 erine/Threonine protein kinases, catalytic domain 210381 Serine/Threonine protein kinases, catalytic domain 210417 Thrombospondin type 1 repeats 210424 Thrombospondin type 1 repeats 210429 Histone H3 210457 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 210457 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 210465 Homeodomain 210507 ankyrin repeats 210510 Tudor domain 210530 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 210535 Immunoglobulin 210619 Tyrosine kinase, catalytic domain 210619 erine/Threonine protein kinases, catalytic domain 210619 Serine/Threonine protein kinases, catalytic domain 210622 Trypsin-like serine protease 210622 Domain abundant in complement control proteins 210622 Trypsin-like serine protease 210622 Domain abundant in complement control proteins 210622 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 210622 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 210670 krueppel associated box 210710 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 210710 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 210714 Rab subfamily of small GTPases 210714 Ras subfamily of RAS small GTPases 210714 Rho (Ras homology) subfamily of Ras-like small GTPases 210714 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 210719 Homeodomain 210719 Homeodomain 210766 JAB/MPN domain 210789 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 210801 Immunoglobulin C-2 Type 210801 Thrombospondin type 1 repeats 210801 Domain present in ZO-1 and Unc5-like netrin receptors 210801 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 210853 krueppel associated box 210869 Domain with 2 conserved Trp (W) residues 210933 Thrombospondin type 1 repeats 210933 Domain present in hormone receptors 210933 Domain present in hormone receptors 210933 G-protein-coupled receptor proteolytic site domain 210964 Tetratricopeptide repeats 210988 Immunoglobulin 210988 Immunoglobulin V-Type 210994 Immunoglobulin 210994 Immunoglobulin V-Type 211007 associated with SPRY domains 211007 Domain in SPla and the RYanodine Receptor. 211027 Immunoglobulin 211027 Immunoglobulin V-Type 211187 Leucine rich repeat N-terminal domain 211208 K homology RNA-binding domain 211232 von Willebrand factor (vWF) type A domain 211232 von Willebrand factor (vWF) type A domain 211241 Short calmodulin-binding motif containing conserved Ile and Gln residues 211255 Kelch domain 211255 Broad-Complex, Tramtrack and Bric a brac 211300 Trypsin-like serine protease 211323 Immunoglobulin 211329 domain in TBC and LysM domain containing proteins 211331 Immunoglobulin 211331 Immunoglobulin V-Type 211332 Kinesin motor, catalytic domain. ATPase 211332 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 211334 Immunoglobulin 211334 Immunoglobulin V-Type 211336 Immunoglobulin V-Type 211348 Immunoglobulin 211348 Immunoglobulin V-Type 211391 Ribosomal protein L11/L12 211429 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 211430 Dysferlin domain, N-terminal region 211430 Protein kinase C conserved region 2 (CalB) 211441 Immunoglobulin 211441 Immunoglobulin V-Type 211468 Cyclic nucleotide-monophosphate binding domain 211468 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 211496 Serine/Threonine protein kinases, catalytic domain 211496 Tyrosine kinase, catalytic domain 211496 Serine/Threonine protein kinases, catalytic domain 211496 erine/Threonine protein kinases, catalytic domain 211502 Immunoglobulin 211502 Immunoglobulin V-Type 211538 ADAM Cysteine-Rich Domain 211538 Homologues of snake disintegrins 211539 SERine Proteinase INhibitors 211563 SERine Proteinase INhibitors 211565 SERine Proteinase INhibitors 211572 krueppel associated box 211652 Domain with 2 conserved Trp (W) residues 211669 Tyrosine kinase, catalytic domain 211669 erine/Threonine protein kinases, catalytic domain 211669 Serine/Threonine protein kinases, catalytic domain 211673 Sec7 domain 211702 Ring finger 211705 prohibitin homologues 211712 Cadherin repeats 211712 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 211739 Immunoglobulin 211757 Transforming growth factor-beta (TGF-beta) family 211759 catalytic domain of ctd-like phosphatases 211770 Serine/Threonine protein kinases, catalytic domain 211844 Immunoglobulin 211857 Found in Pit-Oct-Unc transcription factors 211870 RNA recognition motif 211895 high mobility group 211896 Domain found in Dishevelled, Egl-10, and Pleckstrin 211903 Actin depolymerisation factor/cofilin -like domains 211914 ankyrin repeats 211914 Src homology 3 domains 211924 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 211924 Cadherin repeats 211924 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 211945 Band 4.1 homologues 211945 Domain in Myosin and Kinesin Tails 211945 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 211945 Band 4.1 homologues 211945 Domain in Myosin and Kinesin Tails 211945 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 211949 suppressors of cytokine signalling 211949 Domain in SPla and the RYanodine Receptor. 211970 RNA recognition motif 211983 Tyrosine kinase, catalytic domain 212085 Ring finger 212108 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 212111 Inositol polyphosphate phosphatase, catalytic domain homologues 212122 RNA recognition motif 212139 Protein kinase C conserved region 2 (CalB) 212139 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 212190 Domain present in ubiquitin-regulatory proteins 212190 Domain present in ubiquitin-regulatory proteins 212198 WD40 repeats 212207 RNA recognition motif 212225 Serine/Threonine protein kinases, catalytic domain 212237 Ubiquitin associated domain 212276 krueppel associated box 212278 high mobility group 212281 krueppel associated box 212285 GTPase-activator protein for Rho-like GTPases 212285 Putative GTP-ase activating proteins for the small GTPase, ARF 212285 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 212285 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 212390 Kelch domain 212419 glycine rich nucleic binding domain 212432 Domains in Na-Ca exchangers and integrin-beta4 212507 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 212515 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 212528 zinc finger 212539 Rab subfamily of small GTPases 212539 Ras subfamily of RAS small GTPases 212539 Rho (Ras homology) subfamily of Ras-like small GTPases 212539 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 212569 krueppel associated box 212608 Broad-Complex, Tramtrack and Bric a brac 212634 Src homology 3 domains 212677 Paired Box domain 212684 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 212684 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 212710 Rab subfamily of small GTPases 212710 Ras subfamily of RAS small GTPases 212710 Rho (Ras homology) subfamily of Ras-like small GTPases 212712 Homeodomain 212718 Immunoglobulin 212718 Immunoglobulin V-Type 212722 Ubiquitin homologues 212725 meprin and TRAF homology 212725 Broad-Complex, Tramtrack and Bric a brac 212727 meprin and TRAF homology 212727 Broad-Complex, Tramtrack and Bric a brac 212747 WD40 repeats 212763 Histone H3 212815 Ring finger 212815 zinc finger 212819 zinc finger 212819 glycine rich nucleic binding domain 212932 SERine Proteinase INhibitors 212961 SERine Proteinase INhibitors 212996 Ricin-type beta-trefoil 212997 DEAD-like helicases superfamily 212997 helicase superfamily c-terminal domain 213014 krueppel associated box 213019 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 213019 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 213027 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 213030 Calponin homology domain 213032 krueppel associated box 213033 Actin 213037 RNA recognition motif 213038 krueppel associated box 213079 high mobility group 213084 Serine/Threonine protein kinases, catalytic domain 213109 PHD zinc finger 213109 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 213119 Integrin alpha (beta-propellor repeats) 213119 von Willebrand factor (vWF) type A domain 213121 ankyrin repeats 213156 Immunoglobulin 213156 Immunoglobulin V-Type 213171 Trypsin-like serine protease 213177 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 213212 P or trefoil or TFF domain 213233 Immunoglobulin 213233 Immunoglobulin C-Type 213236 RNA recognition motif 213262 Immunoglobulin 213262 Kazal type serine protease inhibitors 213311 A Receptor for Ubiquitination Targets 213311 A Receptor for Ubiquitination Targets 213320 HAT (Half-A-TPR) repeats 213325 erine/Threonine protein kinases, catalytic domain 213325 Serine/Threonine protein kinases, catalytic domain 213326 Tyrosine kinase, catalytic domain 213326 Serine/Threonine protein kinases, catalytic domain 213389 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 213409 in nuclear membrane-associated proteins 213411 Dual specificity phosphatase, catalytic domain 213411 Protein tyrosine phosphatase, catalytic domain 213411 Protein tyrosine phosphatase, catalytic domain motif 213417 Kelch domain 213420 RNA recognition motif 213426 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 213428 Fibronectin type 3 domain 213435 Serine/Threonine protein kinases, catalytic domain 213435 Tyrosine kinase, catalytic domain 213435 erine/Threonine protein kinases, catalytic domain 213435 Serine/Threonine protein kinases, catalytic domain 213436 zinc finger 213440 high mobility group 213454 Ring finger 213474 RNA recognition motif 213480 Immunoglobulin 213480 Immunoglobulin V-Type 213481 Immunoglobulin 213481 Immunoglobulin V-Type 213498 Regulator of G protein signalling domain 213498 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 213499 A Receptor for Ubiquitination Targets 213522 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 213522 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 213527 Domain present in hormone receptors 213533 Ubiquitin homologues 213556 Band 4.1 homologues 213556 Domain in Myosin and Kinesin Tails 213556 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 213556 Domain in Myosin and Kinesin Tails 213556 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 213570 Immunoglobulin 213570 Immunoglobulin V-Type 213573 Eps15 homology domain 213584 glycine rich nucleic binding domain 213611 Protein tyrosine phosphatase, catalytic domain 213611 Protein tyrosine phosphatase, catalytic domain motif 213649 Src homology 3 domains 213649 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 213684 Immunoglobulin V-Type 213702 erine/Threonine protein kinases, catalytic domain 213702 Serine/Threonine protein kinases, catalytic domain 213758 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 213784 ATPases associated with a variety of cellular activities 213856 Histone H3 213898 Ubiquitin homologues 213923 Epsin N-terminal homology (ENTH) domain 213943 von Willebrand factor (vWF) type A domain 213943 BPTI/Kunitz family of serine protease inhibitors 213943 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 213945 von Willebrand factor (vWF) type A domain 213946 WD40 repeats 213946 suppressors of cytokine signalling 213988 RNA recognition motif 213990 Ras subfamily of RAS small GTPases 213990 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 214029 Immunoglobulin 214029 Immunoglobulin V-Type 214031 Immunoglobulin 214031 Immunoglobulin V-Type 214048 Domain in the RNA-binding Lupus La protein 214066 Zinc finger domain 214066 RNA recognition motif 214105 high mobility group 214137 GTPase-activator protein for Rho-like GTPases 214137 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 214137 GTPase-activator protein for Rho-like GTPases 214137 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 214141 Ribosomal protein L11/L12 214149 A domain family that is part of the cupin metalloenzyme superfamily 214149 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 214151 RNA recognition motif 214158 Ring finger 214158 B-Box-type zinc finger 214158 B-Box C-terminal domain 214158 Modified RING finger domain 214158 associated with SPRY domains 214158 Domain in SPla and the RYanodine Receptor. 214162 bromo domain 214162 PHD zinc finger 214162 "FY-rich" domain, N-terminal region 214162 "FY-rich" domain, C-terminal region 214162 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 214198 Immunoglobulin 214198 Immunoglobulin V-Type 214198 Domain present in PSD-95, Dlg, and ZO-1/2 214198 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 214230 P21-Rho-binding domain 214230 Tyrosine kinase, catalytic domain 214230 Serine/Threonine protein kinases, catalytic domain 214238 Immunoglobulin 214238 Immunoglobulin V-Type 214238 Immunoglobulin C-2 Type 214283 Immunoglobulin 214283 Immunoglobulin V-Type 214286 krueppel associated box 214299 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 214301 Beta/gamma crystallins 214308 K homology RNA-binding domain 214321 ADAM Cysteine-Rich Domain 214321 Homologues of snake disintegrins 214403 Domain abundant in complement control proteins 214425 Immunoglobulin C-2 Type 214425 Thrombospondin type 1 repeats 214447 WD40 repeats 214450 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 214450 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 214459 Src homology 3 domains 214488 Ring finger 214488 K homology RNA-binding domain 214523 Scavenger receptor Cys-rich 214523 Trypsin-like serine protease 214531 Scavenger receptor Cys-rich 214531 Trypsin-like serine protease 214534 Ubiquitin homologues 214545 Spectrin repeats 214545 Calponin homology domain 214547 Src homology 2 domains 214575 Tudor domain 214593 EF-hand, calcium binding motif 214616 ATPases associated with a variety of cellular activities 214639 Papain family cysteine protease 214639 Papain family cysteine protease 214652 Ring finger 214669 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 214670 Immunoglobulin 214670 Immunoglobulin V-Type 214673 HAT (Half-A-TPR) repeats 214676 Papain family cysteine protease 214682 Myosin. Large ATPases. ATPase 214682 Serine/Threonine protein kinases, catalytic domain 214682 Myosin. Large ATPases 214742 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 214766 Zinc-dependent metalloprotease 214766 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me 214779 krueppel associated box 214783 Fibronectin type 3 domain 214783 associated with SPRY domains 214783 Domain in SPla and the RYanodine Receptor. 214795 RNA recognition motif 214804 GTPase-activator protein for Rho-like GTPases 214820 Immunoglobulin 214820 Immunoglobulin V-Type 214849 Immunoglobulin 214849 Immunoglobulin V-Type 214854 Ring finger 214854 domain in neuralized proteins 214854 Ring finger 214854 domain in neuralized proteins 214855 ARID (A/T-rich interaction domain) domain 214862 Immunoglobulin 214862 Immunoglobulin V-Type 214880 krueppel associated box 214891 Immunoglobulin 214891 Immunoglobulin V-Type 214899 PHD zinc finger 214899 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 214952 Rho (Ras homology) subfamily of Ras-like small GTPases 214968 semaphorin domain 214968 domain found in Plexins, Semaphorins and Integrins 214968 semaphorin domain 214968 domain found in Plexins, Semaphorins and Integrins 214976 Immunoglobulin 214976 Immunoglobulin V-Type 215001 BPTI/Kunitz family of serine protease inhibitors 215001 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 215055 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 215061 B-Box C-terminal domain 215061 associated with SPRY domains 215061 Domain in SPla and the RYanodine Receptor. 215061 Ring finger 215061 B-Box-type zinc finger 215061 B-Box C-terminal domain 215061 Modified RING finger domain 215061 associated with SPRY domains 215061 Domain in SPla and the RYanodine Receptor. 215093 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 215114 I/LWEQ domain 215157 Domain abundant in complement control proteins 215192 krueppel associated box 215204 G protein gamma subunit-like motifs 215208 krueppel associated box 215253 DEAD-like helicases superfamily 215257 Interleukin-1 homologues 215274 Interleukin-1 homologues 215303 Serine/Threonine protein kinases, catalytic domain 215378 membrane-attack complex / perforin 215393 Immunoglobulin 215393 Immunoglobulin V-Type 215408 Immunoglobulin 215408 Immunoglobulin C-2 Type 215408 Thrombospondin type 1 repeats 215409 Immunoglobulin 215409 Immunoglobulin C-2 Type 215409 Thrombospondin type 1 repeats 215419 Coagulation factor 5/8 C-terminal domain, discoidin domain 215422 Laminin G domain 215422 Coagulation factor 5/8 C-terminal domain, discoidin domain 215423 Laminin G domain 215428 Domain abundant in complement control proteins 215428 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 215428 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 215446 Serine/Threonine protein kinases, catalytic domain 215449 Rab subfamily of small GTPases 215449 Ras subfamily of RAS small GTPases 215449 Rho (Ras homology) subfamily of Ras-like small GTPases 215449 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 215452 krueppel associated box 215453 Ring finger 215544 Histidine kinase-like ATPases 215632 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 215632 Sec7 domain 215632 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 215653 Ras association (RalGDS/AF-6) domain 215654 Cadherin repeats 215654 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 215690 ATPases associated with a variety of cellular activities 215734 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 215748 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 215748 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 215798 Pentraxin / C-reactive protein / pentaxin family 215798 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 215798 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 215802 high mobility group 215865 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 215890 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 215919 Ring finger 215941 snRNP Sm proteins 215948 ATPases associated with a variety of cellular activities 215988 glycine rich nucleic binding domain 215996 zinc finger 216020 DEAD-like helicases superfamily 216020 helicase superfamily c-terminal domain 216024 RNA recognition motif 216082 erythroblast transformation specific domain 216148 Src homology 2 domains 216148 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 216150 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 216152 Acid phosphatase homologues 216154 WD40 repeats 216156 WD40 repeats 216166 Tyrosine kinase, catalytic domain 216166 Serine/Threonine protein kinases, catalytic domain 216166 erine/Threonine protein kinases, catalytic domain 216177 krueppel associated box 216178 Tyrosine kinase, catalytic domain 216178 erine/Threonine protein kinases, catalytic domain 216178 Serine/Threonine protein kinases, catalytic domain 216190 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 216210 DEAD-like helicases superfamily 216223 Immunoglobulin 216223 Fibronectin type 3 domain 216229 WD40 repeats 216233 Src homology 2 domains 216233 suppressors of cytokine signalling 216238 Protein present in Fab1, YOTB, Vac1, and EEA1 216294 RNA recognition motif 216299 von Willebrand factor (vWF) type D domain 216344 ARF-like small GTPases 216344 Rab subfamily of small GTPases 216344 Ras subfamily of RAS small GTPases 216344 Sar1p-like members of the Ras-family of small GTPases 216344 Rho (Ras homology) subfamily of Ras-like small GTPases 216344 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 216439 Rab subfamily of small GTPases 216439 Ras subfamily of RAS small GTPases 216439 Rho (Ras homology) subfamily of Ras-like small GTPases 216439 Putative GTP-ase activating proteins for the small GTPase, ARF 216439 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 216445 GTPase-activator protein for Rho-like GTPases 216445 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 216456 ankyrin repeats 216505 Kringle domain 216505 Kringle domain 216524 Ubiquitin homologues 216530 Adenylyl- / guanylyl cyclase, catalytic domain 216544 Ribosomal protein L11/L12 216551 Galectin 216551 Galectin 216616 Calcium-binding EGF-like domain 216622 ankyrin repeats 216636 Ubiquitin homologues 216678 high mobility group 216705 Epsin N-terminal homology (ENTH) domain 216725 Thrombospondin type 1 repeats 216725 Thrombospondin type 1 repeats 216760 Immunoglobulin C-2 Type 216781 Ring finger 216781 B-Box-type zinc finger 216781 associated with SPRY domains 216781 Domain in SPla and the RYanodine Receptor. 216790 RIO-like kinase 216790 Tyrosine kinase, catalytic domain 216790 erine/Threonine protein kinases, catalytic domain 216790 Serine/Threonine protein kinases, catalytic domain 216797 Trypsin-like serine protease 216798 In Between Ring fingers 216800 high mobility group 216810 Domain present in VPS-27, Hrs and STAM 216817 RNA recognition motif 216818 Ubiquitin homologues 216831 BAR domain 216831 GTPase-activator protein for Rho-like GTPases 216850 A domain family that is part of the cupin metalloenzyme superfamily 216850 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 216859 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 216860 domain in neuralized proteins 216860 Domain in SPla and the RYanodine Receptor. 216873 Putative single-stranded nucleic acids-binding domain 216877 DEAD-like helicases superfamily 216877 helicase superfamily c-terminal domain 216881 present in yeast cell wall integrity and stress response component proteins 216881 present in yeast cell wall integrity and stress response component proteins 216953 GTPase-activator protein for Rho-like GTPases 216959 helix loop helix domain 216961 WD40 repeats 216963 Putative GTP-ase activating proteins for the small GTPase, ARF 216963 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins 216976 Tyrosine kinase, catalytic domain 216976 erine/Threonine protein kinases, catalytic domain 216976 Serine/Threonine protein kinases, catalytic domain 216990 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 216991 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 217031 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 217066 Ubiquitin homologues 217069 Ring finger 217069 associated with SPRY domains 217069 Domain in SPla and the RYanodine Receptor. 217082 basic region leucin zipper 217082 basic region leucin zipper 217123 Fibrillar collagens C-terminal domain 217123 von Willebrand factor (vWF) type C domain 217124 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 217125 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 217125 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 217136 basic region leucin zipper 217149 CDGSH-type zinc finger. Function unknown 217151 G protein alpha subunit 217151 ARF-like small GTPases 217151 Rab subfamily of small GTPases 217151 Ras subfamily of RAS small GTPases 217151 Rho (Ras homology) subfamily of Ras-like small GTPases 217151 Sar1p-like members of the Ras-family of small GTPases 217151 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 217164 RNA recognition motif 217167 Connexin homologues 217169 Src homology 2 domains 217169 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 217198 Band 4.1 homologues 217198 Domain in Myosin and Kinesin Tails 217201 domain involved in Ras-like GTPase signaling 217228 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 217245 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 217252 Immunoglobulin 217303 Immunoglobulin 217304 Immunoglobulin 217322 Src homology 3 domains 217328 Band 4.1 homologues 217328 Domain in Myosin and Kinesin Tails 217333 associated with SPRY domains 217342 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 217351 RNA recognition motif 217351 Ubiquitin associated domain 217371 Rab subfamily of small GTPases 217371 suppressors of cytokine signalling 217378 Rab subfamily of small GTPases 217379 Domain of unknown function present in FAF1 (Fas-associated factor 1) 217384 Tudor domain 217397 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 217410 Serine/Threonine protein kinases, catalytic domain 217463 Domain associated with PX domains 217463 Regulator of G protein signalling domain 217463 PhoX homologous domain, present in p47phox and p40phox 217463 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 217480 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 217480 Diacylglycerol kinase accessory domain (presumed) 217480 Diacylglycerol kinase catalytic domain (presumed) 217480 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 217503 SERine Proteinase INhibitors 217536 Ribosomal RNA adenine dimethylases 217558 Domain Homologous to E6-AP Carboxyl Terminus with 217566 RNA recognition motif 217578 bromo domain 217653 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 217674 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 217674 Glycoprotein hormone beta chain homologues 217674 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 217682 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 217684 Domain abundant in complement control proteins 217684 Domain abundant in complement control proteins 217690 Src homology 3 domains 217690 Tyrosine kinase, catalytic domain 217690 Serine/Threonine protein kinases, catalytic domain 217692 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 217695 Protein present in Fab1, YOTB, Vac1, and EEA1 217718 Serine/Threonine protein kinases, catalytic domain 217738 Thrombospondin type 1 repeats 217767 high mobility group 217835 Ras association (RalGDS/AF-6) domain 217835 Domain present in VPS9 217835 Ras association (RalGDS/AF-6) domain 217849 SERine Proteinase INhibitors 217852 SERine Proteinase INhibitors 217854 SERine Proteinase INhibitors 217864 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 217866 P21-Rho-binding domain 217866 Tyrosine kinase, catalytic domain 217866 Extension to Ser/Thr-type protein kinases 217866 erine/Threonine protein kinases, catalytic domain 217866 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 217866 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 217869 domain present in translation initiation factor eIF2B and eIF5 217869 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 217886 Domain present in PSD-95, Dlg, and ZO-1/2 217886 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 217908 Immunoglobulin 217908 Immunoglobulin V-Type 217914 Immunoglobulin V-Type 217915 Immunoglobulin V-Type 217916 Immunoglobulin 217916 Immunoglobulin V-Type 217917 Immunoglobulin V-Type 217918 Immunoglobulin 217918 Immunoglobulin V-Type 217921 high mobility group 217922 high mobility group 217926 high mobility group 217927 Immunoglobulin 217927 Immunoglobulin V-Type 217928 Immunoglobulin 217928 Immunoglobulin V-Type 217930 Immunoglobulin 217930 Immunoglobulin V-Type 217931 Immunoglobulin 217931 Immunoglobulin V-Type 217932 Immunoglobulin 217932 Immunoglobulin V-Type 217944 Guanine nucleotide exchange factor for Ras-like GTPases 217944 Guanine nucleotide exchange factor for Ras-like small GTPases 217944 Guanine nucleotide exchange factor for Ras-like small GTPases 217958 EF-hand, calcium binding motif 217980 Domain in the RNA-binding Lupus La protein 218024 glycine rich nucleic binding domain 218025 ARF-like small GTPases 218025 Sar1p-like members of the Ras-family of small GTPases 218030 Found in Pit-Oct-Unc transcription factors 218035 Clathrin heavy chain repeat homology 218038 BAR domain 218038 Src homology 3 domains 218039 Immunoglobulin 218039 Immunoglobulin V-Type 218075 erine/Threonine protein kinases, catalytic domain 218075 Serine/Threonine protein kinases, catalytic domain 218102 Histone H4 218146 SERine Proteinase INhibitors 218171 Domain of unknown function present in FAF1 (Fas-associated factor 1) 218194 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 218203 Band 4.1 homologues 218210 Zinc finger domain 218215 In Between Ring fingers 218241 Tyrosine kinase, catalytic domain 218241 erine/Threonine protein kinases, catalytic domain 218241 Serine/Threonine protein kinases, catalytic domain 218244 Tyrosine kinase, catalytic domain 218244 erine/Threonine protein kinases, catalytic domain 218244 Serine/Threonine protein kinases, catalytic domain 218272 Tyrosine kinase, catalytic domain 218272 erine/Threonine protein kinases, catalytic domain 218272 Serine/Threonine protein kinases, catalytic domain 218297 Broad-Complex, Tramtrack and Bric a brac 218304 Trypsin-like serine protease 218310 krueppel associated box 218313 krueppel associated box 218314 krueppel associated box 218314 krueppel associated box 218324 krueppel associated box 218340 krueppel associated box 218360 Low molecular weight phosphatase family 218397 GTPase-activator protein for Ras-like GTPases 218411 glycine rich nucleic binding domain 218432 K homology RNA-binding domain 218440 ankyrin repeats 218456 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 218461 PAS domain 218476 ankyrin repeats 218501 Calponin homology domain 218503 Fes/CIP4 homology domain 218524 high mobility group 218538 erythroblast transformation specific domain 218543 RNA recognition motif 218580 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 218581 GTPase-activator protein for Rho-like GTPases 218581 Domain found in Dishevelled, Egl-10, and Pleckstrin 218581 GTPase-activator protein for Rho-like GTPases 218581 Domain found in Dishevelled, Egl-10, and Pleckstrin 218613 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 218614 Tyrosine kinase, catalytic domain 218614 erine/Threonine protein kinases, catalytic domain 218614 Serine/Threonine protein kinases, catalytic domain 218617 PB1 domain 218617 Src homology 3 domains 218630 domain present in cyclins, TFIIB and Retinoblastoma 218631 Trypsin-like serine protease 218699 Serine/Threonine protein kinases, catalytic domain 218744 Cadherin repeats 218744 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 218750 high mobility group 218757 RIO-like kinase 218757 Tyrosine kinase, catalytic domain 218757 erine/Threonine protein kinases, catalytic domain 218757 Serine/Threonine protein kinases, catalytic domain 218759 Tyrosine kinase, catalytic domain 218759 erine/Threonine protein kinases, catalytic domain 218759 Serine/Threonine protein kinases, catalytic domain 218763 Leucine rich repeat N-terminal domain 218767 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 218772 Ligand binding domain of hormone receptors 218772 c4 zinc finger in nuclear hormone receptors 218814 Histone H3 218877 semaphorin domain 218877 domain found in Plexins, Semaphorins and Integrins 218921 Guanine nucleotide exchange factor for Ras-like GTPases 218921 uanine nucleotide exchange factor for Ras-like GTPases 218921 Guanine nucleotide exchange factor for Ras-like GTPases 218945 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 218952 Band 4.1 homologues 218963 Ubiquitin homologues 219033 Pancreatic ribonuclease 219036 Pancreatic ribonuclease 219037 krueppel associated box 219044 Chromatin organization modifier domain 219054 Immunoglobulin 219054 Immunoglobulin V-Type 219057 Immunoglobulin 219057 Immunoglobulin V-Type 219058 Immunoglobulin 219058 Immunoglobulin V-Type 219060 Immunoglobulin 219060 Immunoglobulin 219060 Immunoglobulin V-Type 219060 Immunoglobulin C-2 Type 219061 Immunoglobulin 219061 Immunoglobulin V-Type 219065 Immunoglobulin C-Type 219065 Immunoglobulin V-Type 219081 Putative single-stranded nucleic acids-binding domain 219105 zinc finger in transposases and transcription factors 219107 domain present in cyclins, TFIIB and Retinoblastoma 219133 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 219135 Protein tyrosine phosphatase, catalytic domain motif 219140 Src homology 3 domains 219140 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 219140 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 219144 ARF-like small GTPases 219144 Rab subfamily of small GTPases 219144 Sar1p-like members of the Ras-family of small GTPases 219145 RNA recognition motif 219150 Homeodomain 219150 Homeodomain 219183 Diacylglycerol kinase accessory domain (presumed) 219183 Diacylglycerol kinase catalytic domain (presumed) 219183 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 219186 high mobility group 219189 von Willebrand factor (vWF) type A domain 219189 von Willebrand factor (vWF) type A domain 219249 Tudor domain 219257 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 219257 Cadherin repeats 219257 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 219293 ATPases associated with a variety of cellular activities 219346 Homeodomain 219409 Homeodomain 219414 RNA recognition motif 219442 Domain in SPla and the RYanodine Receptor. 219527 Leucine rich repeat C-terminal domain 219527 Leucine rich repeat N-terminal domain 219537 Calponin homology domain 219681 Armadillo/beta-catenin-like repeats 219699 Immunoglobulin 219699 Thrombospondin type 1 repeats 219699 Domain present in ZO-1 and Unc5-like netrin receptors 219699 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 219749 krueppel associated box 219756 Serine/Threonine protein kinases, catalytic domain 219790 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 219902 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 219961 helicase superfamily c-terminal domain 219972 membrane-attack complex / perforin 219976 membrane-attack complex / perforin 219996 Zona pellucida (ZP) domain 220027 Adenylyl- / guanylyl cyclase, catalytic domain 220077 Phosphotyrosine-binding domain (IRS1-like) 220078 RRM_1 domain 220115 Protein tyrosine phosphatase, catalytic domain 220115 Protein tyrosine phosphatase, catalytic domain motif 220164 Phosphotyrosine-binding domain (IRS1-like) 220202 helix loop helix domain 220296 Immunoglobulin C-2 Type 220359 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 220466 Putative GTP-ase activating proteins for the small GTPase, ARF 220466 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 220486 Ring finger 220486 Domain in SPla and the RYanodine Receptor. 220635 PHD zinc finger 220672 ATPases associated with a variety of cellular activities 220686 Phosphoinositide 3-kinase, catalytic domain 220830 Src homology 3 domains 220830 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 220840 RNA recognition motif 220848 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 220988 RNA recognition motif 220992 krueppel associated box 221002 Guanine nucleotide exchange factor for Ras-like GTPases 221002 Guanine nucleotide exchange factor for Ras-like small GTPases 221009 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 221078 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 221079 G protein alpha subunit 221079 ARF-like small GTPases 221079 Rab subfamily of small GTPases 221079 Ras subfamily of RAS small GTPases 221079 Sar1p-like members of the Ras-family of small GTPases 221091 Fibronectin type 3 domain 221092 Domain in SPla and the RYanodine Receptor. 221092 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 221178 Src homology 3 domains 221178 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 221184 von Willebrand factor (vWF) type A domain 221184 Protein kinase C conserved region 2 (CalB) 221191 Trypsin-like serine protease 221259 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins 221267 Calponin homology domain 221278 Ring finger 221278 associated with SPRY domains 221278 Domain in SPla and the RYanodine Receptor. 221322 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 221395 Immunoglobulin 221395 G-protein-coupled receptor proteolytic site domain 221395 Domain found in sea urchin sperm protein, enterokinase, agrin 221400 Tudor domain 221456 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 221472 Protein present in Fab1, YOTB, Vac1, and EEA1 221472 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 221472 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 221476 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 221496 in nuclear membrane-associated proteins 221496 in nuclear membrane-associated proteins 221547 ARF-like small GTPases 221547 Rab subfamily of small GTPases 221547 Ras subfamily of RAS small GTPases 221547 Rho (Ras homology) subfamily of Ras-like small GTPases 221547 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 221549 Immunoglobulin C-Type 221566 DEAD-like helicases superfamily 221572 ARF-like small GTPases 221572 Sar1p-like members of the Ras-family of small GTPases 221608 associated with SPRY domains 221608 Domain in SPla and the RYanodine Receptor. 221613 Histone 2A 221622 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 221654 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 221692 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 221710 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 221831 Ras subfamily of RAS small GTPases 221889 RNA recognition motif 221890 ATPases associated with a variety of cellular activities 221933 Immunoglobulin 221933 Immunoglobulin C-2 Type 221935 Immunoglobulin 221935 Immunoglobulin C-2 Type 221935 Fibronectin type 3 domain 221937 FORKHEAD 221937 Forkhead associated domain 221948 EF-hand, calcium binding motif 222008 Immunoglobulin 222008 Immunoglobulin 222019 Ubiquitin homologues 222032 krueppel associated box 222229 WD40 repeats 222256 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 222258 WD40 repeats 222346 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 222484 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 222611 G-protein-coupled receptor proteolytic site domain 222643 Domain present in ZO-1 and Unc5-like netrin receptors 222663 Calcium-binding EGF-like domain 222696 leucine rich region 222699 tob/btg1 family 223117 domain found in Plexins, Semaphorins and Integrins 223152 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 223186 U1-like zinc finger 223227 high mobility group 223254 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 223254 Band 4.1 homologues 223254 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 223254 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 223255 Serine/Threonine protein kinases, catalytic domain 223282 factor I membrane attack complex 223319 WD40 repeats 223347 Profilin 223364 Domain present in PSD-95, Dlg, and ZO-1/2 223364 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 223398 DNA-directed RNA-polymerase II subunit 223404 RNA recognition motif 223409 WD40 repeats 223435 Immunoglobulin 223435 Immunoglobulin C-2 Type 223435 Tyrosine kinase, catalytic domain 223435 erine/Threonine protein kinases, catalytic domain 223435 Serine/Threonine protein kinases, catalytic domain 223499 WD40 repeats 223524 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 223526 Ribosomal protein S1-like RNA-binding domain 223594 RNA recognition motif 223599 Immunoglobulin C-2 Type 223631 Ly-6 antigen / uPA receptor -like domain 223635 glycine rich nucleic binding domain 223635 Ly-6 antigen / uPA receptor -like domain 223650 Plectin repeat 223666 Domain in Myosin and Kinesin Tails 223666 GTPase-activator protein for Rho-like GTPases 223669 krueppel associated box 223701 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 223752 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 223754 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 223760 Histone H3 223770 bromo domain 223770 PHD zinc finger 223770 domain with conserved PWWP motif 223782 Kelch domain 223814 Ring finger 223814 Modified RING finger domain 223814 Domain present in PSD-95, Dlg, and ZO-1/2 223814 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 223819 RNA recognition motif 223838 Thrombospondin type 1 repeats 223843 Homeodomain 223864 Guanine nucleotide exchange factor for Ras-like GTPases 223864 Guanine nucleotide exchange factor for Ras-like small GTPases 223881 Rho (Ras homology) subfamily of Ras-like small GTPases 223918 Domain in SPla and the RYanodine Receptor. 223922 basic region leucin zipper 223931 Immunoglobulin 223931 Immunoglobulin V-Type 223934 leucine rich region 223995 Cadherin repeats 223995 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 223998 RNA recognition motif 223998 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein 223998 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 224014 Protein present in Fab1, YOTB, Vac1, and EEA1 224014 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 224014 Protein present in Fab1, YOTB, Vac1, and EEA1 224020 Phosphoinositide 3-kinase, catalytic domain 224020 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 224093 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 224093 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 224105 P21-Rho-binding domain 224105 Tyrosine kinase, catalytic domain 224105 erine/Threonine protein kinases, catalytic domain 224105 Serine/Threonine protein kinases, catalytic domain 224115 von Willebrand factor (vWF) type D domain 224115 Adhesion-associated domain present in MUC4 and other proteins 224115 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 224118 domain involved in Ras-like GTPase signaling 224143 Putative lipopolysaccharide-modifying enzyme 224170 Ring finger 224185 ATPases associated with a variety of cellular activities 224206 minichromosome maintenance proteins 224218 erine/Threonine protein kinases, catalytic domain 224218 Serine/Threonine protein kinases, catalytic domain 224224 Domain found in sea urchin sperm protein, enterokinase, agrin 224273 Beta/gamma crystallins 224273 Ricin-type beta-trefoil 224273 Beta/gamma crystallins 224273 Ricin-type beta-trefoil 224344 RNA recognition motif 224432 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 224432 RNA recognition motif 224432 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 224549 krueppel associated box 224564 high mobility group 224585 krueppel associated box 224603 krueppel associated box 224605 krueppel associated box 224617 domain in TBC and LysM domain containing proteins 224624 Rab subfamily of small GTPases 224650 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 224650 Sterile alpha motif 224650 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 224650 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 224691 krueppel associated box 224692 krueppel associated box 224694 krueppel associated box 224710 Immunoglobulin 224710 Immunoglobulin V-Type 224710 Immunoglobulin C-2 Type 224742 ATPases associated with a variety of cellular activities 224748 Immunoglobulin C-Type 224752 Homeodomain 224753 Immunoglobulin C-Type 224753 Immunoglobulin C-Type 224753 Immunoglobulin C-Type 224754 Immunoglobulin C-Type 224754 Immunoglobulin C-Type 224756 Immunoglobulin C-Type 224756 Immunoglobulin C-Type 224756 Immunoglobulin C-Type 224759 Immunoglobulin C-Type 224761 Immunoglobulin C-Type 224761 Immunoglobulin C-Type 224761 Immunoglobulin C-Type 224762 Ring finger 224762 associated with SPRY domains 224762 Domain in SPla and the RYanodine Receptor. 224769 Immunoglobulin C-Type 224782 Tyrosine kinase, catalytic domain 224782 erine/Threonine protein kinases, catalytic domain 224782 Serine/Threonine protein kinases, catalytic domain 224792 G-protein-coupled receptor proteolytic site domain 224829 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 224860 Phospholipase C, catalytic domain (part) 224860 Protein kinase C conserved region 2 (CalB) 224860 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 224871 Histone H3 224872 DEAD-like helicases superfamily 224872 helicase superfamily c-terminal domain 224875 Tyrosine kinase, catalytic domain 224875 erine/Threonine protein kinases, catalytic domain 224875 Serine/Threonine protein kinases, catalytic domain 224876 Tyrosine kinase, catalytic domain 224876 erine/Threonine protein kinases, catalytic domain 224876 Serine/Threonine protein kinases, catalytic domain 224902 RNA recognition motif 224903 RNA recognition motif 224914 Ring finger 224920 erine/Threonine protein kinases, catalytic domain 224920 Serine/Threonine protein kinases, catalytic domain 225010 Phosphate acyltransferases 225014 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 225022 glycine rich nucleic binding domain 225027 RNA recognition motif 225028 Tyrosine kinase, catalytic domain 225028 erine/Threonine protein kinases, catalytic domain 225028 Serine/Threonine protein kinases, catalytic domain 225028 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 225055 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 225112 uanine nucleotide exchange factor for Ras-like GTPases 225112 Guanine nucleotide exchange factor for Ras-like GTPases 225114 Cadherin repeats 225114 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 225115 Gelsolin homology domain 225127 zinc finger 225131 Domain with 2 conserved Trp (W) residues 225134 S4 RNA-binding domain 225139 Src homology 2 domains 225151 glycine rich nucleic binding domain 225154 DEAD-like helicases superfamily 225154 helicase superfamily c-terminal domain 225187 ankyrin repeats 225256 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 225266 Kelch domain 225283 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 225288 Formin Homology 2 Domain 225307 RNA recognition motif 225326 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 225326 Phosphoinositide 3-kinase, catalytic domain 225326 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 225326 Phosphoinositide 3-kinase, region postulated to contain C2 domain 225343 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 225353 high mobility group 225358 GTPase-activator protein for Rho-like GTPases 225367 Ubiquitin homologues 225372 Domain with 2 conserved Trp (W) residues 225432 RNA recognition motif 225445 Kazal type serine protease inhibitors 225446 Kazal type serine protease inhibitors 225471 Toll - interleukin 1 - resistance 225503 RNA polymerases D 225527 high mobility group 225600 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 225608 Src homology 3 domains 225631 Homeodomain 225636 zinc finger 225636 RRM_1 domain 225636 RNA recognition motif 225638 Immunoglobulin 225689 Serine/Threonine protein kinases, catalytic domain 225724 Serine/Threonine protein kinases, catalytic domain 225743 Ring finger 225820 Spectrin repeats 225825 Immunoglobulin 225825 Immunoglobulin 225827 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 225870 Domain present in VPS9 225870 Src homology 2 domains 225872 PAS domain 225875 Immunoglobulin 225876 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 225888 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 225896 Domain present in ubiquitin-regulatory proteins 225903 Uteroglobin 225912 Cytochrome b-561 / ferric reductase transmembrane domain 225912 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 225919 DEAD-like helicases superfamily 225958 erine/Threonine protein kinases, catalytic domain 225958 Serine/Threonine protein kinases, catalytic domain 226036 RNA recognition motif 226047 ARF-like small GTPases 226047 Rab subfamily of small GTPases 226047 Ras subfamily of RAS small GTPases 226047 Rho (Ras homology) subfamily of Ras-like small GTPases 226047 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 226049 Doublesex DNA-binding motif 226049 Doublesex DNA-binding motif 226101 Protein kinase C conserved region 2 (CalB) 226101 Protein kinase C conserved region 2 (CalB) 226101 Protein kinase C conserved region 2 (CalB) 226106 c4 zinc finger in nuclear hormone receptors 226119 Laminin G domain 226119 Leucine rich repeat C-terminal domain 226123 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases 226169 RNA recognition motif 226182 WD40 repeats 226243 Kringle domain 226243 Trypsin-like serine protease 226250 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 226251 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 226251 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 226255 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 226343 Broad-Complex, Tramtrack and Bric a brac 226344 WD40 repeats 226359 Complement component C1q domain 226359 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 226409 HNH nucleases 226409 Zinc finger domain 226409 DEAD-like helicases superfamily 226409 helicase superfamily c-terminal domain 226412 Putative single-stranded nucleic acids-binding domain 226419 Serine/Threonine protein kinases, catalytic domain 226422 Rab subfamily of small GTPases 226438 Immunoglobulin 226438 Fibronectin type 3 domain 226438 Immunoglobulin 226438 Immunoglobulin C-2 Type 226438 Fibronectin type 3 domain 226439 helix loop helix domain 226479 Histone H3 226519 Laminin-type epidermal growth factor-like domai 226519 Laminin B domain 226519 Laminin N-terminal domain (domain VI) 226519 Laminin-type epidermal growth factor-like domai 226519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 226541 Kelch domain 226554 Dynamin GTPase effector domain 226641 basic region leucin zipper 226654 Rhodanese Homology Domain 226673 Dual specificity phosphatase, catalytic domain 226673 Protein tyrosine phosphatase, catalytic domain 226673 Protein tyrosine phosphatase, catalytic domain motif 226685 Pentraxin / C-reactive protein / pentaxin family 226723 RNA recognition motif 226732 Forkhead associated domain 226751 P21-Rho-binding domain 226751 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 226751 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 226751 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 226778 Ubiquitin associated domain 226778 Serine/Threonine protein kinases, catalytic domain 226783 Homeodomain 226830 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 226856 Phosphate acyltransferases 226856 Phosphate acyltransferases 226877 high mobility group 226885 high mobility group 226885 domain in Ataxins and HMG containing proteins 226928 Protein kinase C conserved region 2 (CalB) 226948 DEAD-like helicases superfamily 226948 helicase superfamily c-terminal domain 226952 Tyrosine kinase, catalytic domain 226952 erine/Threonine protein kinases, catalytic domain 226952 Serine/Threonine protein kinases, catalytic domain 226954 RNA recognition motif 226955 RNA recognition motif 226956 RNA recognition motif 226970 Src homology 3 domains 226970 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 226970 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 226971 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 226977 Actin 227035 ARF-like small GTPases 227035 Sar1p-like members of the Ras-family of small GTPases 227036 ARF-like small GTPases 227036 Rab subfamily of small GTPases 227036 Ras subfamily of RAS small GTPases 227036 DnaJ molecular chaperone homology domain 227036 Rho (Ras homology) subfamily of Ras-like small GTPases 227036 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 227044 Chromo Shadow Domain 227044 Chromatin organization modifier domain 227061 DnaJ molecular chaperone homology domain 227078 RNA recognition motif 227092 high mobility group 227099 high mobility group 227106 Protein kinase C conserved region 2 (CalB) 227120 Phospholipase C, catalytic domain (part) 227120 Protein kinase C conserved region 2 (CalB) 227134 Homeodomain 227154 Serine/Threonine protein kinases, catalytic domain 227154 Serine/Threonine protein kinases, catalytic domain 227157 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 227157 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 227234 Kinesin motor, catalytic domain. ATPase 227234 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 227292 catalytic domain of ctd-like phosphatases 227325 Calcium-binding EGF-like domain 227333 Diacylglycerol kinase accessory domain (presumed) 227333 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 227333 Sterile alpha motif 227333 Diacylglycerol kinase accessory domain (presumed) 227333 Diacylglycerol kinase catalytic domain (presumed) 227333 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 227333 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 227335 Armadillo/beta-catenin-like repeats 227377 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 227377 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 227384 Sigma factor PP2C-like phosphatases 227384 Serine/threonine phosphatases, family 2C, catalytic domain 227388 RNA recognition motif 227411 Coagulation factor 5/8 C-terminal domain, discoidin domain 227412 Laminin G domain 227412 Coagulation factor 5/8 C-terminal domain, discoidin domain 227449 zinc finger 227458 SERine Proteinase INhibitors 227460 SERine Proteinase INhibitors 227462 SERine Proteinase INhibitors 227513 krueppel associated box 227541 Serine/Threonine protein kinases, catalytic domain 227541 erine/Threonine protein kinases, catalytic domain 227541 Serine/Threonine protein kinases, catalytic domain 227564 RNA recognition motif 227570 ankyrin repeats 227572 ankyrin repeats 227580 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 227588 eukaryotic translation initiation factor 1A 227624 Rab subfamily of small GTPases 227644 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 227656 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 227677 Homeodomain 227700 BAR domain 227712 Immunoglobulin 227712 G2 nidogen domain and fibulin 227712 Calcium-binding EGF-like domain 227712 Immunoglobulin 227712 Immunoglobulin C-2 Type 227712 G2 nidogen domain and fibulin 227712 Calcium-binding EGF-like domain 227712 Epidermal growth factor-like domain 227721 Acid phosphatase homologues 227733 Phosphatidylinositol phosphate kinases 227744 DnaJ molecular chaperone homology domain 227753 Gelsolin homology domain 227802 Pentraxin / C-reactive protein / pentaxin family 227802 G-protein-coupled receptor proteolytic site domain 227929 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 227937 Armadillo/beta-catenin-like repeats 227940 bromo domain 227940 PHD zinc finger 227945 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 227945 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 227989 14-3-3 homologues 227995 Actin 228003 Kelch domain 228012 Serine/Threonine protein kinases, catalytic domain 228065 Domain present in phytochromes and cGMP-specific phosphodiesterases 228065 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 228071 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 228071 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 228199 Dynamin, GTPase 228235 ARF-like small GTPases 228235 Sar1p-like members of the Ras-family of small GTPases 228237 erine/Threonine protein kinases, catalytic domain 228237 Serine/Threonine protein kinases, catalytic domain 228357 Calcium-binding EGF-like domain 228357 Low-density lipoprotein-receptor YWTD domain 228357 Low-density lipoprotein receptor domain class A 228359 GTPase-activator protein for Rho-like GTPases 228359 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 228384 Tyrosine kinase, catalytic domain 228413 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 228413 Domain containing Gla (gamma-carboxyglutamate) residues 228413 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 228419 Ribosomal protein S1-like RNA-binding domain 228482 GTPase-activator protein for Rho-like GTPases 228482 GTPase-activator protein for Rho-like GTPases 228507 Rab subfamily of small GTPases 228507 Ras subfamily of RAS small GTPases 228515 Rab subfamily of small GTPases 228515 Ras subfamily of RAS small GTPases 228515 Rho (Ras homology) subfamily of Ras-like small GTPases 228515 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 228543 Rho (Ras homology) subfamily of Ras-like small GTPases 228549 Histone H3 228569 Src homology 2 domains 228592 Immunoglobulin C-Type 228592 Immunoglobulin C-Type 228604 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 228633 AN1-like Zinc finger 228684 Sel1-like repeats 228684 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 228692 Appr-1"-p processing enzyme 228731 Homeodomain 228756 Cystatin-like domain 228756 Cystatin-like domain 228765 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 228775 Serine/Threonine protein kinases, catalytic domain 228775 Serine/Threonine protein kinases, catalytic domain 228785 Tyrosine kinase, catalytic domain 228785 erine/Threonine protein kinases, catalytic domain 228785 Serine/Threonine protein kinases, catalytic domain 228796 BPI/LBP/CETP C-terminal domain 228801 BPI/LBP/CETP C-terminal domain 228802 BPI/LBP/CETP N-terminal domain 228804 krueppel associated box 228839 Homeodomain 228840 domain in TBC and LysM domain containing proteins 228861 BPTI/Kunitz family of serine protease inhibitors 228861 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 228876 krueppel associated box 228876 krueppel associated box 228880 bromo domain 228942 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 228942 Complement component C1q domain 228942 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 228960 Helical region found in SNAREs 228961 Domain of unknown function in Sec63p, Brr2p and other proteins 228980 TAF homology 229004 SAND domain 229005 Tyrosine kinase, catalytic domain 229005 erine/Threonine protein kinases, catalytic domain 229005 Serine/Threonine protein kinases, catalytic domain 229007 zinc finger 229007 glycine rich nucleic binding domain 229017 krueppel associated box 229027 RNA recognition motif 229040 catalytic domain of ctd-like phosphatases 229055 zinc finger 229064 Ubiquitin homologues 229087 high mobility group 229095 c4 zinc finger in nuclear hormone receptors 229118 Ring finger 229119 B-Box C-terminal domain 229152 Cullin 229207 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 229269 GTPase-activator protein for Rho-like GTPases 229270 GTPase-activator protein for Rho-like GTPases 229274 RNA recognition motif 229278 Domains in Na-Ca exchangers and integrin-beta4 229280 RNA recognition motif 229332 Chromatin organization modifier domain 229348 RNA recognition motif 229358 domain in high mobilty group proteins HMG14 and HMG 17 229389 Complement component C1q domain 229389 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 229418 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 229445 Papain family cysteine protease 229445 Papain family cysteine protease 229458 Cadherin repeats 229458 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 229459 Cadherin repeats 229459 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 229474 Formin Homology 2 Domain 229476 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 229499 Immunoglobulin 229500 erythroblast transformation specific domain 229504 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 229504 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 229521 Protein kinase C conserved region 2 (CalB) 229545 Protein phosphatase 2A homologues, catalytic domain 229545 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 229547 PhoX homologous domain, present in p47phox and p40phox 229547 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 229569 Homeodomain 229570 14-3-3 homologues 229571 Broad-Complex, Tramtrack and Bric a brac 229584 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 229607 Histone 2A 229608 Histone H2B 229626 RNA recognition motif 229631 14-3-3 homologues 229644 B-Box-type zinc finger 229644 B-Box C-terminal domain 229644 Filamin-type immunoglobulin domains 229644 B-Box-type zinc finger 229644 B-Box C-terminal domain 229644 Filamin-type immunoglobulin domains 229663 Cold shock protein domain 229687 Glyco_18 domain 229688 Glyco_18 domain 229688 Glyco_18 domain 229700 RNA recognition motif 229751 Aamy_C domain 229751 Alpha-amylase domain 229752 Aamy_C domain 229752 Alpha-amylase domain 229756 krueppel associated box 229759 Olfactomedin-like domains 229759 Olfactomedin-like domains 229772 erythroblast transformation specific domain 229776 Dual specificity phosphatase, catalytic domain 229776 Protein tyrosine phosphatase, catalytic domain 229776 Protein tyrosine phosphatase, catalytic domain motif 229791 Acid phosphatase homologues 229801 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep 229879 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 229927 von Willebrand factor (vWF) type A domain 229933 von Willebrand factor (vWF) type A domain 229933 von Willebrand factor (vWF) type A domain 229958 Dual specificity phosphatase, catalytic domain 229958 Protein tyrosine phosphatase, catalytic domain 229958 Protein tyrosine phosphatase, catalytic domain motif 229992 domain in splicing factors 229994 domain in transcription and CHROMO domain helicases 230002 Armadillo/beta-catenin-like repeats 230006 Ubiquitin homologues 230010 RNA recognition motif 230010 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein 230010 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 230043 G protein gamma subunit-like motifs 230054 high mobility group 230098 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 230098 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 230103 Adenylyl- / guanylyl cyclase, catalytic domain 230103 Tyrosine kinase, catalytic domain 230103 Adenylyl- / guanylyl cyclase, catalytic domain 230103 erine/Threonine protein kinases, catalytic domain 230103 Serine/Threonine protein kinases, catalytic domain 230126 Src homology 2 domains 230145 Ricin-type beta-trefoil 230162 krueppel associated box 230220 Histone H3 230235 Possible catecholamine-binding domain present in a variety of eukaryotic proteins 230235 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at present 230251 leucine rich region 230251 krueppel associated box 230257 RNA recognition motif 230260 domain with conserved PWWP motif 230280 Tumour necrosis factor family 230280 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 230316 Laminin-type epidermal growth factor-like domai 230344 Domains in Na-Ca exchangers and integrin-beta4 230346 krueppel associated box 230367 Ribosomal RNA adenine dimethylases 230396 Interferon alpha, beta and delta 230396 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 230397 Interferon alpha, beta and delta 230397 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 230398 Interferon alpha, beta and delta 230398 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 230401 Interferon alpha, beta and delta 230401 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 230405 Interferon alpha, beta and delta 230405 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 230448 JAB/MPN domain 230474 RNA recognition motif 230483 Homeodomain 230558 Thrombospondin type 1 repeats 230562 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 230622 Immunoglobulin 230622 Immunoglobulin V-Type 230674 Tudor domain 230674 PHD zinc finger 230674 Small domain found in the jumonji family of transcription factors 230674 A domain family that is part of the cupin metalloenzyme superfamily 230674 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 230692 domain present in cyclins, TFIIB and Retinoblastoma 230700 FORKHEAD 230735 Ephrin receptor ligand binding domain 230760 Domain abundant in complement control proteins 230760 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 230760 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 230771 RNA recognition motif 230774 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 230775 Thrombospondin type 1 repeats 230775 Thrombospondin type 1 repeats 230775 Domain present in hormone receptors 230775 G-protein-coupled receptor proteolytic site domain 230796 WD40 repeats 230796 Tetratricopeptide repeats 230799 14-3-3 homologues 230806 Beta/gamma crystallins 230809 Serine/Threonine protein kinases, catalytic domain 230837 ankyrin repeats 230837 Putative GTP-ase activating proteins for the small GTPase, ARF 230868 Immunoglobulin 230868 Immunoglobulin C-2 Type 230887 Forkhead associated domain 230899 Natriuretic peptide 230908 RNA recognition motif 230936 PHD zinc finger 230972 Src homology 3 domains 230972 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 230979 Tumor necrosis factor receptor / nerve growth factor receptor repeats 231002 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 231003 Kelch domain 231003 Broad-Complex, Tramtrack and Bric a brac 231032 Cadherin repeats 231032 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 231033 RNA recognition motif 231042 zinc finger 231044 Homeodomain 231050 Ricin-type beta-trefoil 231051 PHD zinc finger 231051 "FY-rich" domain, C-terminal region 231051 "FY-rich" domain, N-terminal region 231051 Cysteine-rich motif following a subset of SET domains 231051 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 231078 Domain in DAP-5, eIF4G, MA-3 and other proteins 231078 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 231093 Zn_pept domain 231098 DnaJ molecular chaperone homology domain 231109 Domain present in PSD-95, Dlg, and ZO-1/2 231109 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 231109 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 231109 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 231118 Homeodomain 231125 Protein present in Fab1, YOTB, Vac1, and EEA1 231148 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 231151 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 231151 Zinc-binding domain, present in Dystrophin, CREB-binding protein 231151 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 231207 RNA recognition motif 231207 RNA recognition motif 231227 ARF-like small GTPases 231227 Rab subfamily of small GTPases 231227 Ras subfamily of RAS small GTPases 231227 Rho (Ras homology) subfamily of Ras-like small GTPases 231227 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 231234 Domain present in ubiquitin-regulatory proteins 231234 Domain of unknown function present in FAF1 (Fas-associated factor 1) 231242 translation initiation factor 6 231248 krueppel associated box 231251 Small MutS-related domain 231381 Trypsin-like serine protease 231381 Domain found in sea urchin sperm protein, enterokinase, agrin 231382 Trypsin-like serine protease 231392 GTPase-activator protein for Rho-like GTPases 231413 RNA recognition motif 231413 RNA recognition motif 231470 Domains in Na-Ca exchangers and integrin-beta4 231470 Domains in Na-Ca exchangers and integrin-beta4 231510 Phosphate acyltransferases 231532 GTPase-activator protein for Rho-like GTPases 231532 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 231532 GTPase-activator protein for Rho-like GTPases 231565 Zona pellucida (ZP) domain 231573 snRNP Sm proteins 231580 Tyrosine kinase, catalytic domain 231580 DnaJ molecular chaperone homology domain 231580 erine/Threonine protein kinases, catalytic domain 231580 Serine/Threonine protein kinases, catalytic domain 231605 Ricin-type beta-trefoil 231613 Spectrin repeats 231613 Syntaxin N-terminal domain 231613 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 231613 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 231666 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 231717 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 231717 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 231760 Src homology 3 domains 231760 Fibronectin type 3 domain 231769 Suppressor-of-White-APricot splicing regulator 231769 Suppressor-of-White-APricot splicing regulator 231798 Calponin homology domain 231801 Putative GTP-ase activating proteins for the small GTPase, ARF 231801 Putative GTP-ase activating proteins for the small GTPase, ARF 231811 Chromatin organization modifier domain 231821 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 231830 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 231830 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 231836 Kinesin motor, catalytic domain. ATPase 231836 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 231837 Histone H3 231866 krueppel associated box 231866 krueppel associated box 231869 domain present in cyclins, TFIIB and Retinoblastoma 231885 uanine nucleotide exchange factor for Ras-like GTPases 231885 Guanine nucleotide exchange factor for Ras-like GTPases 231894 uanine nucleotide exchange factor for Ras-like GTPases 231894 Guanine nucleotide exchange factor for Ras-like GTPases 231895 uanine nucleotide exchange factor for Ras-like GTPases 231895 Guanine nucleotide exchange factor for Ras-like GTPases 231896 uanine nucleotide exchange factor for Ras-like GTPases 231896 Guanine nucleotide exchange factor for Ras-like GTPases 231991 basic region leucin zipper 231999 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 232045 Immunoglobulin 232045 Immunoglobulin V-Type 232048 Immunoglobulin 232048 Immunoglobulin V-Type 232050 Immunoglobulin 232050 Immunoglobulin V-Type 232051 Immunoglobulin 232051 Immunoglobulin V-Type 232052 Immunoglobulin 232052 Immunoglobulin V-Type 232053 Immunoglobulin 232053 Immunoglobulin V-Type 232055 Immunoglobulin 232055 Immunoglobulin V-Type 232057 Immunoglobulin 232057 Immunoglobulin V-Type 232059 Immunoglobulin 232059 Immunoglobulin V-Type 232060 Immunoglobulin 232060 Immunoglobulin V-Type 232060 Immunoglobulin C-2 Type 232061 Immunoglobulin 232062 Immunoglobulin V-Type 232063 Immunoglobulin 232063 Immunoglobulin V-Type 232065 Immunoglobulin 232065 Immunoglobulin V-Type 232066 Immunoglobulin 232066 Immunoglobulin V-Type 232067 Immunoglobulin 232067 Immunoglobulin V-Type 232068 Immunoglobulin 232068 Immunoglobulin V-Type 232072 Immunoglobulin 232072 Immunoglobulin V-Type 232074 Immunoglobulin 232074 Immunoglobulin V-Type 232077 FORKHEAD 232119 DEAD-like helicases superfamily 232119 helicase superfamily c-terminal domain 232143 high mobility group 232187 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 232201 GTPase-activator protein for Rho-like GTPases 232201 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 232227 Sec7 domain 232227 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 232237 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 232273 Eps15 homology domain 232273 EF-hand, calcium binding motif 232288 Band 4.1 homologues 232327 Putative GTP-ase activating proteins for the small GTPase, ARF 232336 Lipoxygenase homology 2 (beta barrel) domain 232338 Src homology 3 domains 232338 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 232338 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 232338 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 232361 BCL (B-Cell lymphoma) 232364 RNA recognition motif 232368 Ubiquitin associated domain 232370 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 232371 Trypsin-like serine protease 232371 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 232371 Trypsin-like serine protease 232371 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 232371 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 232401 Domain present in VPS-27, Hrs and STAM 232408 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232408 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232409 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232413 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232413 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232414 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232415 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 232421 krueppel associated box 232433 DEAD-like helicases superfamily 232433 helicase superfamily c-terminal domain 232440 Histone 2A 232440 Histone 2A 232441 Ras subfamily of RAS small GTPases 232441 Rab subfamily of small GTPases 232441 Ras subfamily of RAS small GTPases 232441 Rho (Ras homology) subfamily of Ras-like small GTPases 232441 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 232465 Cullin 232533 Serine/Threonine protein kinases, catalytic domain 232539 Kelch domain 232560 Complement component C1q domain 232560 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 232569 Broad-Complex, Tramtrack and Bric a brac 232585 Calcium-binding EGF-like domain 232585 von Willebrand factor (vWF) type D domain 232598 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 232598 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 232619 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 232665 Calponin homology domain 232680 Zn_pept domain 232706 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 232714 P or trefoil or TFF domain 232716 Immunoglobulin 232717 Trypsin-like serine protease 232717 Trypsin-like serine protease 232717 Trypsin-like serine protease 232718 Trypsin-like serine protease 232723 Immunoglobulin 232723 Immunoglobulin V-Type 232724 Immunoglobulin V-Type 232725 Immunoglobulin V-Type 232727 Immunoglobulin 232727 Immunoglobulin V-Type 232728 Immunoglobulin 232728 Immunoglobulin V-Type 232758 Immunoglobulin 232758 Immunoglobulin V-Type 232759 Immunoglobulin 232759 Immunoglobulin V-Type 232774 Coagulation factor 5/8 C-terminal domain, discoidin domain 232775 Laminin G domain 232780 Double-stranded RNA binding motif 232787 krueppel associated box 232793 Immunoglobulin 232811 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 232818 erine/Threonine protein kinases, catalytic domain 232822 Epsin N-terminal homology (ENTH) domain 232836 Galanin 232852 krueppel associated box 232853 krueppel associated box 232855 krueppel associated box 232860 Serine/Threonine protein kinases, catalytic domain 232867 leucine rich region 232868 leucine rich region 232875 leucine rich region 232878 leucine rich region 232879 zinc finger 232879 Broad-Complex, Tramtrack and Bric a brac 232883 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 232887 WD40 repeats 232899 Homeodomain 232900 Homeodomain 232901 Homeodomain 232917 Immunoglobulin 232917 Immunoglobulin C-2 Type 232918 Immunoglobulin 232918 Immunoglobulin C-2 Type 232919 Immunoglobulin 232919 Immunoglobulin C-2 Type 232930 Protein tyrosine phosphatase, catalytic domain motif 232930 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 232931 Immunoglobulin 232931 Immunoglobulin C-2 Type 232932 Immunoglobulin 232932 Immunoglobulin C-2 Type 232941 Serine/threonine phosphatases, family 2C, catalytic domain 232941 Serine/threonine phosphatases, family 2C, catalytic domain 232944 Serine/Threonine protein kinases, catalytic domain 232958 Tyrosine kinase, catalytic domain 232958 erine/Threonine protein kinases, catalytic domain 232958 Serine/Threonine protein kinases, catalytic domain 232963 RIO-like kinase 232963 Tyrosine kinase, catalytic domain 232963 erine/Threonine protein kinases, catalytic domain 232963 Serine/Threonine protein kinases, catalytic domain 232968 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 232974 erythroblast transformation specific domain 232978 Tyrosine kinase, catalytic domain 232978 erine/Threonine protein kinases, catalytic domain 232978 Serine/Threonine protein kinases, catalytic domain 232989 Domain in SPla and the RYanodine Receptor. 232989 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 233024 PB1 domain 233024 Tyrosine kinase, catalytic domain 233024 erine/Threonine protein kinases, catalytic domain 233024 Serine/Threonine protein kinases, catalytic domain 233024 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 233033 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 233033 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 233046 Guanine nucleotide exchange factor for Ras-like small GTPases 233055 zinc finger 233056 krueppel associated box 233057 krueppel associated box 233057 krueppel associated box 233061 krueppel associated box 233067 Immunoglobulin 233067 Immunoglobulin 233067 Immunoglobulin C-2 Type 233067 Fibronectin type 3 domain 233069 Tyrosine kinase, catalytic domain 233071 Src homology 3 domains 233071 GTPase-activator protein for Rho-like GTPases 233071 Src homology 3 domains 233071 GTPase-activator protein for Rho-like GTPases 233073 RRM_1 domain 233087 Uteroglobin 233098 Ubiquitin homologues 233111 Low-density lipoprotein receptor domain class A 233111 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 233111 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 233147 krueppel associated box 233166 bromo domain 233168 krueppel associated box 233174 high mobility group 233176 domain present in cyclins, TFIIB and Retinoblastoma 233181 glycine rich nucleic binding domain 233183 Serine/threonine phosphatases, family 2C, catalytic domain 233184 krueppel associated box 233186 Immunoglobulin 233190 Trypsin-like serine protease 233199 Immunoglobulin 233199 Fibronectin type 3 domain 233199 Immunoglobulin 233199 Fibronectin type 3 domain 233204 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 233281 Zinc-binding domain, present in Dystrophin, CREB-binding protein 233297 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 233330 Homeodomain 233330 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 233426 K homology RNA-binding domain 233493 Ubiquitin homologues 233508 14-3-3 homologues 233529 Broad-Complex, Tramtrack and Bric a brac 233532 PHD zinc finger 233564 domain present in cyclins, TFIIB and Retinoblastoma 233637 Actin depolymerisation factor/cofilin -like domains 233649 Cyclic nucleotide-monophosphate binding domain 233651 Cadherin repeats 233651 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 233669 Chromo Shadow Domain 233669 Chromatin organization modifier domain 233733 Ricin-type beta-trefoil 233733 Ricin-type beta-trefoil 233808 ATPases associated with a variety of cellular activities 233813 von Willebrand factor (vWF) type A domain 233813 von Willebrand factor (vWF) type A domain 233832 zinc finger 233832 Ring finger 233835 RNA recognition motif 233878 Domain abundant in complement control proteins 233878 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 233885 Double-stranded RNA binding motif 233892 Ubiquitin homologues 233893 krueppel associated box 233904 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 233910 Ring finger 233910 B-Box-type zinc finger 233910 Domain in SPla and the RYanodine Receptor. 234094 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 234107 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 234107 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 234129 domain in high mobilty group proteins HMG14 and HMG 17 234132 snRNP Sm proteins 234135 domain with conserved PWWP motif 234185 domain present in cyclins, TFIIB and Retinoblastoma 234199 Fibrinogen-related domains (FReDs) 234210 ADAM Cysteine-Rich Domain 234214 Src homology 3 domains 234214 Src homology 3 domains 234254 Ubiquitin homologues 234313 RNA recognition motif 234329 associated with SPRY domains 234329 Domain in SPla and the RYanodine Receptor. 234353 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 234353 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 234358 krueppel associated box 234362 krueppel associated box 234374 DEAD-like helicases superfamily 234374 helicase superfamily c-terminal domain 234400 14-3-3 homologues 234427 Domain abundant in complement control proteins 234456 c4 zinc finger in nuclear hormone receptors 234460 Ligand binding domain of hormone receptors 234546 Ubiquitin homologues 234577 von Willebrand factor (vWF) type A domain 234596 Histone 2A 234596 Appr-1"-p processing enzyme 234622 RNA polymerase subunit CX 234635 Immunoglobulin 234635 Immunoglobulin V-Type 234684 A Receptor for Ubiquitination Targets 234684 A Receptor for Ubiquitination Targets 234686 Formin Homology 2 Domain 234686 Formin Homology 2 Domain 234699 WD40 repeats 234725 krueppel associated box 234751 Fibrillar collagens C-terminal domain 234779 Src homology 2 domains 234779 Phospholipase C, catalytic domain (part) 234779 Phospholipase C, catalytic domain (part) 234779 Protein kinase C conserved region 2 (CalB) 234793 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 234796 Kelch domain 234854 Tyrosine kinase, catalytic domain 234854 erine/Threonine protein kinases, catalytic domain 234854 Serine/Threonine protein kinases, catalytic domain 234878 Src homology 3 domains 234886 zinc finger 234889 Adenylyl- / guanylyl cyclase, catalytic domain 234911 Hemopexin-like repeats 234911 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 234922 Src homology 3 domains 234939 snRNP Sm proteins 234973 Cadherin repeats 234973 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 235019 glycine rich nucleic binding domain 235028 krueppel associated box 235047 krueppel associated box 235048 krueppel associated box 235048 krueppel associated box 235050 krueppel associated box 235086 Immunoglobulin 235086 Immunoglobulin C-2 Type 235087 erine/Threonine protein kinases, catalytic domain 235087 Serine/Threonine protein kinases, catalytic domain 235104 Immunoglobulin 235104 Immunoglobulin C-2 Type 235106 Immunoglobulin 235106 Immunoglobulin C-2 Type 235106 Immunoglobulin 235106 Immunoglobulin C-2 Type 235130 ADAM Cysteine-Rich Domain 235130 Thrombospondin type 1 repeats 235281 Immunoglobulin V-Type 235281 Immunoglobulin V-Type 235300 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 235312 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 235315 Ring finger 235315 Ring finger 235320 zinc finger 235341 Calponin homology domain 235344 Serine/Threonine protein kinases, catalytic domain 235344 Tyrosine kinase, catalytic domain 235344 erine/Threonine protein kinases, catalytic domain 235344 Serine/Threonine protein kinases, catalytic domain 235379 Olfactomedin-like domains 235384 ARF-like small GTPases 235384 Rab subfamily of small GTPases 235384 Ras subfamily of RAS small GTPases 235384 Sar1p-like members of the Ras-family of small GTPases 235384 Rho (Ras homology) subfamily of Ras-like small GTPases 235384 ATPases associated with a variety of cellular activities 235384 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 235392 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 235394 DnaJ molecular chaperone homology domain 235402 Immunoglobulin 235406 Src homology 3 domains 235406 Src homology 3 domains 235406 PhoX homologous domain, present in p47phox and p40phox 235406 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 235427 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 235440 WD40 repeats 235440 Domain Homologous to E6-AP Carboxyl Terminus with 235444 ankyrin repeats 235472 Immunoglobulin 235472 Fibronectin type 3 domain 235472 Immunoglobulin 235472 Immunoglobulin C-2 Type 235472 Fibronectin type 3 domain 235480 Protein kinase C conserved region 2 (CalB) 235486 Ligand binding domain of hormone receptors 235513 Ubiquitin homologues 235517 high mobility group 235554 Armadillo/beta-catenin-like repeats 235559 breast cancer carboxy-terminal domain 235567 DnaJ molecular chaperone homology domain 235580 von Willebrand factor (vWF) type A domain 235604 Serine/Threonine protein kinases, catalytic domain 235611 semaphorin domain 235611 ig-like, plexins, transcription factors 235611 GTPase-activator protein for Ras-like GTPases 235611 domain found in Plexins, Semaphorins and Integrins 235612 A Receptor for Ubiquitination Targets 235612 A Receptor for Ubiquitination Targets 235623 WD40 repeats 235624 Protein tyrosine phosphatase, catalytic domain 235624 Protein tyrosine phosphatase, catalytic domain motif 235626 Domain with 2 conserved Trp (W) residues 235628 Trypsin-like serine protease 235631 Trypsin-like serine protease 235718 Tyrosine kinase, catalytic domain 235718 erine/Threonine protein kinases, catalytic domain 235718 Serine/Threonine protein kinases, catalytic domain 235758 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 235762 Immunoglobulin 235762 Immunoglobulin V-Type 235800 Interferon alpha, beta and delta 235800 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 235805 Immunoglobulin 235805 Immunoglobulin V-Type 235841 Homeodomain 235858 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 235861 Immunoglobulin 235861 Immunoglobulin V-Type 235881 Tyrosine kinase, catalytic domain 235881 erine/Threonine protein kinases, catalytic domain 235881 Serine/Threonine protein kinases, catalytic domain 235895 Immunoglobulin V-Type 235900 RRM_1 domain 235900 RNA recognition motif 235907 krueppel associated box 235908 Immunoglobulin 235908 Immunoglobulin V-Type 235923 Protein phosphatase 2A homologues, catalytic domain 235925 SERine Proteinase INhibitors 235934 Immunoglobulin 235934 Immunoglobulin V-Type 235952 Immunoglobulin 235952 Immunoglobulin V-Type 235953 14-3-3 homologues 235964 RNA recognition motif 235966 RNA recognition motif 235982 RNA recognition motif 235985 high mobility group 236011 helicase superfamily c-terminal domain 236032 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 236047 Immunoglobulin 236047 Immunoglobulin V-Type 236068 krueppel associated box 236079 Immunoglobulin 236079 Immunoglobulin V-Type 236111 krueppel associated box 236117 Immunoglobulin 236117 Immunoglobulin V-Type 236133 Immunoglobulin 236133 Immunoglobulin V-Type 236150 RIO-like kinase 236150 Tyrosine kinase, catalytic domain 236150 erine/Threonine protein kinases, catalytic domain 236150 Serine/Threonine protein kinases, catalytic domain 236170 Immunoglobulin 236170 Immunoglobulin V-Type 236207 Immunoglobulin 236207 Immunoglobulin V-Type 236214 SERine Proteinase INhibitors 236226 RIO-like kinase 236226 Tyrosine kinase, catalytic domain 236226 erine/Threonine protein kinases, catalytic domain 236226 Serine/Threonine protein kinases, catalytic domain 236238 Broad-Complex, Tramtrack and Bric a brac 236245 Immunoglobulin 236245 Immunoglobulin V-Type 236248 Immunoglobulin 236248 Immunoglobulin V-Type 236271 K homology RNA-binding domain 236294 RNA recognition motif 236307 high mobility group 236317 Pancreatic ribonuclease 236325 krueppel associated box 236334 krueppel associated box 236342 Tyrosine kinase, catalytic domain 236342 erine/Threonine protein kinases, catalytic domain 236342 Serine/Threonine protein kinases, catalytic domain 236347 leucine rich region 236359 eukaryotic translation initiation factor 1A 236370 Uteroglobin 236394 Immunoglobulin 236394 Immunoglobulin V-Type 236407 Immunoglobulin 236407 Immunoglobulin V-Type 236415 Immunoglobulin 236415 Immunoglobulin V-Type 236416 Immunoglobulin 236416 Immunoglobulin V-Type 236420 ADAM Cysteine-Rich Domain 236420 Homologues of snake disintegrins 236421 Immunoglobulin 236421 Immunoglobulin V-Type 236456 Immunoglobulin 236456 Immunoglobulin V-Type 236469 Domain in SPla and the RYanodine Receptor. 236476 Cadherin repeats 236476 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 236552 Immunoglobulin 236552 Immunoglobulin V-Type 236574 RIO-like kinase 236574 Tyrosine kinase, catalytic domain 236574 erine/Threonine protein kinases, catalytic domain 236574 Serine/Threonine protein kinases, catalytic domain 236622 Ubiquitin homologues 236632 RNA recognition motif 236643 Protein kinase C conserved region 2 (CalB) 236644 Protein phosphatase 2A homologues, catalytic domain 236644 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 236649 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 236651 EF-hand, calcium binding motif 236661 Histone 2A 236663 Histone 2A 236702 Found in Skp1 protein family 236721 RNA recognition motif 236729 Histone H3 236732 glycine rich nucleic binding domain 236747 Zinc finger domain 236747 Protein phosphatase 2A homologues, catalytic domain 236747 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 236749 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 236749 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 236762 Homeodomain 236787 leucine rich region 236790 von Willebrand factor (vWF) type A domain 236798 Pentraxin / C-reactive protein / pentaxin family 236798 G-protein-coupled receptor proteolytic site domain 236820 Armadillo/beta-catenin-like repeats 236845 Ran-binding domain 236864 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 236871 high mobility group 236880 Actin 236882 glycine rich nucleic binding domain 236913 RNA recognition motif 236914 Broad-Complex, Tramtrack and Bric a brac 236915 Src homology 3 domains 236915 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 236915 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 236920 GTPase-activator protein for Rho-like GTPases 236920 in StAR and phosphatidylcholine transfer protein 236929 high mobility group 236954 Helical region found in SNAREs 236969 Ring finger 236969 helicase superfamily c-terminal domain 236973 Ring finger 236973 PHD zinc finger 236973 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533 236973 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. Domain in SET domain containing proteins and in Deinococcus radiodurans DRA1533 237004 high mobility group 237005 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 237009 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 237010 Kelch domain 237020 Histone H3 237025 DnaJ molecular chaperone homology domain 237029 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 237030 RNA recognition motif 237032 RNA recognition motif 237036 Calponin homology domain 237073 RNA recognition motif 237081 WD40 repeats 237124 Tyrosine kinase, catalytic domain 237124 erine/Threonine protein kinases, catalytic domain 237124 Serine/Threonine protein kinases, catalytic domain 237130 FORKHEAD 237175 G-protein-coupled receptor proteolytic site domain 237178 Eps15 homology domain 237178 Protein phosphatase 2A homologues, catalytic domain 237178 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 237188 Tyrosine kinase, catalytic domain 237188 erine/Threonine protein kinases, catalytic domain 237188 Serine/Threonine protein kinases, catalytic domain 237234 Band 4.1 homologues 237241 Histone H3 237253 Low-density lipoprotein receptor domain class A 237253 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 237284 G-protein-coupled receptor proteolytic site domain 237296 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 237300 Serine/Threonine protein kinases, catalytic domain 237300 Tyrosine kinase, catalytic domain 237300 erine/Threonine protein kinases, catalytic domain 237300 Serine/Threonine protein kinases, catalytic domain 237323 krueppel associated box 237339 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 237339 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 237342 Armadillo/beta-catenin-like repeats 237353 Src homology 3 domains 237360 Thrombospondin type 1 repeats 237369 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 237391 Dual specificity phosphatase, catalytic domain 237391 Protein tyrosine phosphatase, catalytic domain 237391 Protein tyrosine phosphatase, catalytic domain motif 237397 Protein kinase C conserved region 2 (CalB) 237400 K homology RNA-binding domain 237403 Immunoglobulin 237403 Immunoglobulin C-2 Type 237403 Leucine rich repeat N-terminal domain 237408 krueppel associated box 237409 krueppel associated box 237410 krueppel associated box 237412 krueppel associated box 237415 zinc finger 237436 Calponin homology domain 237438 ankyrin repeats 237459 Serine/Threonine protein kinases, catalytic domain 237459 Serine/Threonine protein kinases, catalytic domain 237499 RNA recognition motif 237500 Tetratricopeptide repeats 237504 Ras association (RalGDS/AF-6) domain 237523 Fibronectin type 3 domain 237523 von Willebrand factor (vWF) type D domain 237523 C-terminal cystine knot-like domain (CTCK) 237523 Protein tyrosine phosphatase, catalytic domain 237523 Protein tyrosine phosphatase, catalytic domain motif 237542 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 237549 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains 237549 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 237564 Kinesin motor, catalytic domain. ATPase 237564 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 237581 RNA recognition motif 237611 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 237611 Src homology 3 domains 237611 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 237612 Broad-Complex, Tramtrack and Bric a brac 237625 Phospholipase A2 237630 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 237694 Serine/Threonine protein kinases, catalytic domain 237711 WD40 repeats 237754 Immunoglobulin 237754 associated with SPRY domains 237754 Domain in SPla and the RYanodine Receptor. 237758 krueppel associated box 237761 ankyrin repeats 237769 krueppel associated box 237771 Ring finger 237771 B-Box-type zinc finger 237771 associated with SPRY domains 237771 Domain in SPla and the RYanodine Receptor. 237775 krueppel associated box 237780 Ubiquitin homologues 237837 krueppel associated box 237868 Toll - interleukin 1 - resistance 237880 prohibitin homologues 237891 Calponin homology domain 237911 DEAD-like helicases superfamily 237911 DEAD-like helicases superfamily 237911 helicase superfamily c-terminal domain 237960 ankyrin repeats 237979 Immunoglobulin 237979 Immunoglobulin C-2 Type 237989 Ring finger 237989 Domain in SPla and the RYanodine Receptor. 238021 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h 238029 krueppel associated box 238057 Transforming growth factor-beta (TGF-beta) family 238074 DnaJ molecular chaperone homology domain 238094 RNA recognition motif 238130 Src homology 3 domains 238143 high mobility group 238162 Spectrin repeats 238199 Forkhead associated domain 238205 Immunoglobulin 238220 Immunoglobulin 238220 Immunoglobulin C-2 Type 238266 Protein kinase C conserved region 2 (CalB) 238294 Galectin 238323 Serine/Threonine protein kinases, catalytic domain 238333 Sterile alpha motif 238333 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 238335 eukaryotic translation initiation factor 1A 238338 RNA recognition motif 238351 zinc finger 238379 Kinesin motor, catalytic domain. ATPase 238379 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 238386 Broad-Complex, Tramtrack and Bric a brac 238393 SERine Proteinase INhibitors 238395 SERine Proteinase INhibitors 238406 ADAM Cysteine-Rich Domain 238406 Homologues of snake disintegrins 238409 Immunoglobulin 238409 Immunoglobulin V-Type 238410 Immunoglobulin 238410 Immunoglobulin V-Type 238412 Immunoglobulin 238412 Immunoglobulin V-Type 238413 Immunoglobulin 238413 Immunoglobulin V-Type 238414 Immunoglobulin 238414 Immunoglobulin V-Type 238418 Immunoglobulin 238418 Immunoglobulin V-Type 238420 Immunoglobulin 238420 Immunoglobulin V-Type 238424 Immunoglobulin 238424 Immunoglobulin V-Type 238425 Immunoglobulin 238425 Immunoglobulin V-Type 238427 Immunoglobulin 238427 Immunoglobulin V-Type 238428 Immunoglobulin 238428 Immunoglobulin V-Type 238433 Immunoglobulin 238433 Immunoglobulin V-Type 238435 Immunoglobulin V-Type 238437 Immunoglobulin 238437 Immunoglobulin V-Type 238439 Immunoglobulin V-Type 238440 Immunoglobulin 238440 Immunoglobulin V-Type 238443 Immunoglobulin 238443 Ubiquitin homologues 238443 Immunoglobulin V-Type 238444 Immunoglobulin 238444 Immunoglobulin V-Type 238445 Immunoglobulin 238445 Immunoglobulin V-Type 238447 Immunoglobulin 238447 Immunoglobulin V-Type 238448 Immunoglobulin 238448 Immunoglobulin V-Type 238547 Histone 2A 238550 Histone H4 238555 Immunoglobulin V-Type 238555 associated with SPRY domains 238555 Immunoglobulin 238555 Immunoglobulin V-Type 238555 associated with SPRY domains 238555 Domain in SPla and the RYanodine Receptor. 238564 RIO-like kinase 238564 Tyrosine kinase, catalytic domain 238564 erine/Threonine protein kinases, catalytic domain 238564 Serine/Threonine protein kinases, catalytic domain 238568 SERine Proteinase INhibitors 238599 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 238623 RNA recognition motif 238637 Src homology 3 domains 238643 Rab subfamily of small GTPases 238643 Ras subfamily of RAS small GTPases 238643 Rho (Ras homology) subfamily of Ras-like small GTPases 238643 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 238680 Laminin G domain 238680 Fibrinogen-related domains (FReDs) 238680 Coagulation factor 5/8 C-terminal domain, discoidin domain 238688 krueppel associated box 238690 krueppel associated box 238692 krueppel associated box 238692 krueppel associated box 238710 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 238722 krueppel associated box 238761 high mobility group 238836 Histone H3 238856 high mobility group 238871 Metal dependent phosphohydrolases with conserved 'HD' motif 238871 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 238896 WD40 repeats 238939 Cadherin repeats 238939 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 238955 Homeodomain 238955 Found in Pit-Oct-Unc transcription factors 238963 ATPases associated with a variety of cellular activities 238974 Protein tyrosine phosphatase, catalytic domain 238974 Dual specificity phosphatase, catalytic domain 238974 Protein tyrosine phosphatase, catalytic domain motif 239013 Histone H3 239027 GTPase-activator protein for Rho-like GTPases 239027 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 239029 von Willebrand factor (vWF) type A domain 239036 uanine nucleotide exchange factor for Ras-like GTPases 239036 Guanine nucleotide exchange factor for Ras-like GTPases 239037 Immunoglobulin 239038 Immunoglobulin 239054 Dual specificity phosphatase, catalytic domain 239054 Protein tyrosine phosphatase, catalytic domain 239054 Protein tyrosine phosphatase, catalytic domain motif 239081 Toll - interleukin 1 - resistance 239090 Immunoglobulin 239090 Immunoglobulin V-Type 239091 Immunoglobulin 239091 Immunoglobulin V-Type 239099 Homeodomain 239106 Trypsin-like serine protease 239122 Methyl-CpG binding domain 239122 N-terminal to some SET domains 239122 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 239126 Complement component C1q domain 239126 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 239134 Adenylyl- / guanylyl cyclase, catalytic domain 239158 Cold shock protein domain 239163 Src homology 3 domains 239188 RNA recognition motif 239189 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 239192 Olfactomedin-like domains 239217 Broad-Complex, Tramtrack and Bric a brac 239250 Leucine rich repeat C-terminal domain 239273 ATPases associated with a variety of cellular activities 239318 Phospholipase C, catalytic domain (part) 239319 Caspase recruitment domain 239337 Thrombospondin type 1 repeats 239337 ADAM Cysteine-Rich Domain 239337 Thrombospondin type 1 repeats 239351 Spectrin repeats 239351 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 239370 Regulator of G protein signalling domain 239392 Histone H3 239393 Low-density lipoprotein receptor domain class A 239420 Domain abundant in complement control proteins 239420 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 239422 Domain abundant in complement control proteins 239422 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 239422 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 239424 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 239424 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 239447 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 239510 Tudor domain 239510 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 239536 Ly-6 antigen / uPA receptor -like domain 239537 Ly-6 antigen / uPA receptor -like domain 239540 basic region leucin zipper 239546 krueppel associated box 239593 Sterile alpha motif 239593 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 239598 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein 239598 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 239609 von Willebrand factor (vWF) type D domain 239611 von Willebrand factor (vWF) type C domain 239611 C-terminal cystine knot-like domain (CTCK) 239615 Domain present in PSD-95, Dlg, and ZO-1/2 239615 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 239618 Domain present in PSD-95, Dlg, and ZO-1/2 239618 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 239652 krueppel associated box 239652 krueppel associated box 239659 Complement component C1q domain 239659 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 239679 Homeodomain 239690 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 239708 domain in splicing factors 239719 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 239724 ankyrin repeats 239728 zinc finger 239731 Src homology 3 domains 239731 Fibronectin type 3 domain 239743 Broad-Complex, Tramtrack and Bric a brac 239755 Ribosomal protein L11/L12 239761 Histone H3 239826 EF-hand, calcium binding motif 239835 Serine/Threonine protein kinases, catalytic domain 239835 Fibronectin type 3 domain 239835 Tyrosine kinase, catalytic domain 239835 erine/Threonine protein kinases, catalytic domain 239835 Serine/Threonine protein kinases, catalytic domain 239852 Zona pellucida (ZP) domain 239852 Zona pellucida (ZP) domain 239853 G-protein-coupled receptor proteolytic site domain 239853 G-protein-coupled receptor proteolytic site domain 239857 Immunoglobulin 239857 Immunoglobulin C-2 Type 239857 Immunoglobulin 239857 Immunoglobulin C-2 Type 239857 putative band 4.1 homologues' binding motif 239863 G protein alpha subunit 239878 Immunoglobulin 239878 Immunoglobulin C-2 Type 239995 Immunoglobulin 239995 Domain present in PSD-95, Dlg, and ZO-1/2 239995 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 239996 Immunoglobulin V-Type 240007 Domain Homologous to E6-AP Carboxyl Terminus with 240027 krueppel associated box 240030 RNA recognition motif 240034 krueppel associated box 240038 krueppel associated box 240039 krueppel associated box 240040 krueppel associated box 240041 krueppel associated box 240047 Hemopexin-like repeats 240047 Zinc-dependent metalloprotease 240047 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 240055 domain in neuralized proteins 240057 Protein kinase C conserved region 2 (CalB) 240057 GTPase-activator protein for Ras-like GTPases 240057 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 240058 von Willebrand factor (vWF) type A domain 240063 krueppel associated box 240064 krueppel associated box 240067 krueppel associated box 240068 krueppel associated box 240069 Histidine kinase-like ATPases 240072 Ubiquitin associated domain 240074 Immunoglobulin 240074 Immunoglobulin V-Type 240074 Domain in SPla and the RYanodine Receptor. 240074 Immunoglobulin 240074 Immunoglobulin V-Type 240074 Domain in SPla and the RYanodine Receptor. 240087 breast cancer carboxy-terminal domain 240089 Histone H3 240091 RIO-like kinase 240091 Immunoglobulin C-Type 240091 Ubiquitin associated domain 240091 Tyrosine kinase, catalytic domain 240091 erine/Threonine protein kinases, catalytic domain 240091 Serine/Threonine protein kinases, catalytic domain 240092 Immunoglobulin C-Type 240093 Ring finger 240094 associated with SPRY domains 240094 Domain in SPla and the RYanodine Receptor. 240095 Immunoglobulin C-Type 240121 B-Box C-terminal domain 240121 Fibronectin type 3 domain 240121 Domain in SPla and the RYanodine Receptor. 240124 zinc finger 240155 Ribosomal protein L11/L12 240168 uanine nucleotide exchange factor for Ras-like GTPases 240168 Guanine nucleotide exchange factor for Ras-like GTPases 240168 Guanine nucleotide exchange factor for Ras-like small GTPases 240168 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 240171 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 240182 Cullin 240182 RNA recognition motif 240183 Ring finger 240232 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 240236 Cystatin-like domain 240255 helicase superfamily c-terminal domain 240284 WD40 repeats 240322 Thrombospondin type 1 repeats 240354 Immunoglobulin 240354 Immunoglobulin C-2 Type 240396 Ring finger 240396 K homology RNA-binding domain 240411 Lipoxygenase homology 2 (beta barrel) domain 240413 Immunoglobulin 240413 Immunoglobulin V-Type 240442 Homeodomain 240490 high mobility group 240493 Phosphotyrosine-binding domain (IRS1-like) 240495 zinc finger 240498 krueppel associated box 240516 RNA recognition motif 240525 Low-density lipoprotein-receptor YWTD domain 240539 Sterile alpha motif 240539 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 240590 Doublesex DNA-binding motif 240590 Doublesex DNA-binding motif 240595 Broad-Complex, Tramtrack and Bric a brac 240641 Kinesin motor, catalytic domain. ATPase 240641 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 240656 high mobility group 240657 ATPases associated with a variety of cellular activities 240667 WD40 repeats 240669 Domain in histone families 1 and 5 240672 Rhodanese Homology Domain 240672 Protein tyrosine phosphatase, catalytic domain 240672 Dual specificity phosphatase, catalytic domain 240672 Protein tyrosine phosphatase, catalytic domain motif 240675 von Willebrand factor (vWF) type A domain 240710 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 240726 Kazal type serine protease inhibitors 240752 PI3-kinase family, Ras-binding domain 240752 Protein kinase C conserved region 2 (CalB) 240752 Phosphoinositide 3-kinase, catalytic domain 240752 PhoX homologous domain, present in p47phox and p40phox 240752 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 240752 Phosphoinositide 3-kinase, region postulated to contain C2 domain 240753 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 240753 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 240753 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 240756 Kelch domain 240756 Kelch domain 240756 Broad-Complex, Tramtrack and Bric a brac 240773 Domain abundant in complement control proteins 240783 Regulator of G protein signalling domain 240816 Regulator of G protein signalling domain 240843 membrane-attack complex / perforin 240871 Cyclic nucleotide-monophosphate binding domain 240892 Dual specificity phosphatase, catalytic domain 240913 ADAM Cysteine-Rich Domain 240913 Thrombospondin type 1 repeats 240916 Immunoglobulin 240916 Immunoglobulin V-Type 240916 Immunoglobulin 240916 Immunoglobulin V-Type 240958 Tyrosine kinase, catalytic domain 240958 erine/Threonine protein kinases, catalytic domain 240958 Serine/Threonine protein kinases, catalytic domain 241003 Fibronectin type 3 domain 241004 Fibronectin type 3 domain 241005 Fibronectin type 3 domain 241035 ig-like, plexins, transcription factors 241051 Serine/Threonine protein kinases, catalytic domain 241053 Ribosomal protein L11/L12 241054 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 241056 RNA recognition motif 241059 RNA recognition motif 241063 ankyrin repeats 241071 Zinc finger in DBF-like proteins 241073 Zinc-binding domain, present in Dystrophin, CREB-binding protein 241073 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 241075 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 241075 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 241079 Tyrosine kinase, catalytic domain 241079 erine/Threonine protein kinases, catalytic domain 241079 Serine/Threonine protein kinases, catalytic domain 241080 Tyrosine kinase, catalytic domain 241080 erine/Threonine protein kinases, catalytic domain 241080 Serine/Threonine protein kinases, catalytic domain 241109 Protein tyrosine phosphatase, catalytic domain motif 241111 domain involved in Ras-like GTPase signaling 241152 krueppel associated box 241153 Actin depolymerisation factor/cofilin -like domains 241154 ARF-like small GTPases 241154 Rab subfamily of small GTPases 241154 Ras subfamily of RAS small GTPases 241154 Sar1p-like members of the Ras-family of small GTPases 241154 Rho (Ras homology) subfamily of Ras-like small GTPases 241175 Laminin G domain 241180 Laminin G domain 241196 SERine Proteinase INhibitors 241197 SERine Proteinase INhibitors 241201 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 241213 Laminin G domain 241213 Coagulation factor 5/8 C-terminal domain, discoidin domain 241215 Laminin G domain 241219 Middle domain of eukaryotic initiation factor 4G (eIF4G) 241226 Integrin alpha (beta-propellor repeats) 241226 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 241228 Calcium-binding EGF-like domain 241228 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 241228 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 241270 Ring finger 241275 Src homology 3 domains 241308 Guanine nucleotide exchange factor for Ras-like small GTPases 241311 Broad-Complex, Tramtrack and Bric a brac 241324 Laminin G domain 241325 Thymosin beta actin-binding motif 241391 Ricin-type beta-trefoil 241432 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 241432 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 241470 EF-hand, calcium binding motif 241489 Domain present in phytochromes and cGMP-specific phosphodiesterases 241489 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 241489 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 241490 RNA recognition motif 241490 RNA recognition motif 241494 U1-like zinc finger 241494 U1-like zinc finger 241521 Middle domain of eukaryotic initiation factor 4G (eIF4G) 241521 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 241528 Leucine rich repeat C-terminal domain 241528 Leucine rich repeat N-terminal domain 241534 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 241540 Homeodomain 241568 Immunoglobulin 241568 Immunoglobulin 241568 Immunoglobulin V-Type 241568 Immunoglobulin C-2 Type 241568 Leucine rich repeat C-terminal domain 241576 Low-density lipoprotein receptor domain class A 241593 Domain with 2 conserved Trp (W) residues 241624 3'-5' exonuclease 241625 Histone H3 241626 Transglutaminase/protease-like homologues 241635 Transcription initiation factor IIE 241636 Transglutaminase/protease-like homologues 241639 Band 4.1 homologues 241639 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 241656 P21-Rho-binding domain 241656 Serine/Threonine protein kinases, catalytic domain 241681 Kinesin motor, catalytic domain. ATPase 241681 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 241709 Ubiquitin homologues 241723 krueppel associated box 241725 TopoisomeraseII 241735 TAF homology 241764 Sterile alpha motif 241764 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 241770 Protein kinase C conserved region 2 (CalB) 241794 Broad-Complex, Tramtrack and Bric a brac 241857 Ubiquitin homologues 241863 Ubiquitin homologues 241864 Tyrosine kinase, catalytic domain 241864 erine/Threonine protein kinases, catalytic domain 241864 Serine/Threonine protein kinases, catalytic domain 241865 Ring finger 241882 krueppel associated box 241897 Immunoglobulin 241897 Immunoglobulin V-Type 241897 Immunoglobulin C-2 Type 241900 Fibronectin type 3 domain 241923 SAND domain 241942 GTPase-activator protein for Rho-like GTPases 241944 krueppel associated box 241965 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 241965 Cadherin repeats 241965 Calcium-binding EGF-like domain 241965 Epidermal growth factor-like domain 241965 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 241989 RNA recognition motif 241992 14-3-3 homologues 241994 Ubiquitin associated domain 241994 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 242037 Ubiquitin homologues 242039 domain present in translation initiation factor eIF2B and eIF5 242039 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 242050 Immunoglobulin 242050 Immunoglobulin C-2 Type 242050 Leucine rich repeat N-terminal domain 242050 Leucine rich repeat C-terminal domain 242051 RNA recognition motif 242051 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 242065 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 242083 Serine/threonine phosphatases, family 2C, catalytic domain 242083 Sigma factor PP2C-like phosphatases 242083 Serine/threonine phosphatases, family 2C, catalytic domain 242088 Cadherin repeats 242088 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 242096 EF-hand, calcium binding motif 242097 Ami_2 domain 242097 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme 242097 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 242099 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme 242099 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 242100 Ami_2 domain 242100 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme 242100 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 242107 meprin and TRAF homology 242107 Broad-Complex, Tramtrack and Bric a brac 242122 Immunoglobulin 242122 Immunoglobulin 242122 Immunoglobulin V-Type 242122 Immunoglobulin C-2 Type 242151 Broad-Complex, Tramtrack and Bric a brac 242153 14-3-3 homologues 242202 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 242205 14-3-3 homologues 242235 Immunoglobulin 242235 Immunoglobulin C-2 Type 242280 Tyrosine kinase, catalytic domain 242280 erine/Threonine protein kinases, catalytic domain 242280 Serine/Threonine protein kinases, catalytic domain 242316 Transforming growth factor-beta (TGF-beta) family 242319 DEAD-like helicases superfamily 242384 Immunoglobulin 242384 Leucine rich repeat C-terminal domain 242384 Immunoglobulin 242384 Immunoglobulin C-2 Type 242384 Leucine rich repeat C-terminal domain 242384 Leucine rich repeat N-terminal domain 242410 Kelch domain 242410 Broad-Complex, Tramtrack and Bric a brac 242417 Band 4.1 homologues 242443 Bacterial periplasmic substrate-binding proteins 242443 Eukaryotic homologues of bacterial periplasmic substrate binding proteins 242443 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 242447 RNA recognition motif 242459 Fibronectin type 3 domain 242459 Domain in SPla and the RYanodine Receptor. 242497 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 242499 Broad-Complex, Tramtrack and Bric a brac 242505 ARF-like small GTPases 242505 Rab subfamily of small GTPases 242505 Ras subfamily of RAS small GTPases 242505 Sar1p-like members of the Ras-family of small GTPases 242505 Rho (Ras homology) subfamily of Ras-like small GTPases 242505 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 242517 Interferon alpha, beta and delta 242517 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 242519 Interferon alpha, beta and delta 242519 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 242521 Kelch domain 242523 Doublesex DNA-binding motif 242523 Doublesex DNA-binding motif 242570 RRM_1 domain 242570 RNA recognition motif 242603 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 242608 Leucine rich repeat N-terminal domain 242620 Doublesex DNA-binding motif 242627 Immunoglobulin V-Type 242662 Protein kinase C conserved region 2 (CalB) 242663 krueppel associated box 242681 ARF-like small GTPases 242681 Rab subfamily of small GTPases 242681 Ras subfamily of RAS small GTPases 242681 Sar1p-like members of the Ras-family of small GTPases 242681 Rho (Ras homology) subfamily of Ras-like small GTPases 242681 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 242691 glycine rich nucleic binding domain 242702 Immunoglobulin 242702 Immunoglobulin C-2 Type 242702 Fibronectin type 3 domain 242703 Histone 2A 242711 Trypsin-like serine protease 242712 Low-density lipoprotein receptor domain class A 242733 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 242735 Leucine rich repeat C-terminal domain 242735 Leucine rich repeat N-terminal domain 242737 K homology RNA-binding domain 242744 high mobility group 242744 krueppel associated box 242747 krueppel associated box 242785 Kelch domain 242785 Broad-Complex, Tramtrack and Bric a brac 242805 ankyrin repeats 242819 domain involved in Ras-like GTPase signaling 242825 Tyrosine kinase, catalytic domain 242825 erine/Threonine protein kinases, catalytic domain 242825 Serine/Threonine protein kinases, catalytic domain 242842 zinc finger 242851 G protein alpha subunit 242852 G protein alpha subunit 242894 Actin 242914 Kinesin motor, catalytic domain. ATPase 242914 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 242939 Zn_pept domain 242940 Tyrosine kinase, catalytic domain 242940 erine/Threonine protein kinases, catalytic domain 242940 Serine/Threonine protein kinases, catalytic domain 242945 Histone 2A 242960 A Receptor for Ubiquitination Targets 242965 Ubiquitin homologues 243011 Baculoviral inhibition of apoptosis protein repeat 243014 Rab subfamily of small GTPases 243043 Broad-Complex, Tramtrack and Bric a brac 243060 ARF-like small GTPases 243060 Rab subfamily of small GTPases 243060 Ras subfamily of RAS small GTPases 243060 Rho (Ras homology) subfamily of Ras-like small GTPases 243060 Sar1p-like members of the Ras-family of small GTPases 243062 Kazal type serine protease inhibitors 243065 erine/Threonine protein kinases, catalytic domain 243065 Serine/Threonine protein kinases, catalytic domain 243083 Trypsin-like serine protease 243083 Domain found in sea urchin sperm protein, enterokinase, agrin 243083 Trypsin-like serine protease 243083 Domain found in sea urchin sperm protein, enterokinase, agrin 243084 Trypsin-like serine protease 243100 serum albumin 243126 high mobility group 243176 krueppel associated box 243187 Homeodomain 243206 krueppel associated box 243208 krueppel associated box 243209 krueppel associated box 243210 krueppel associated box 243220 present in yeast cell wall integrity and stress response component proteins 243245 Immunoglobulin 243245 Immunoglobulin V-Type 243245 Immunoglobulin C-2 Type 243246 Tyrosine kinase, catalytic domain 243246 erine/Threonine protein kinases, catalytic domain 243246 Serine/Threonine protein kinases, catalytic domain 243272 DEAD-like helicases superfamily 243277 G-protein-coupled receptor proteolytic site domain 243308 krueppel associated box 243311 high mobility group 243312 Leucine rich repeat C-terminal domain 243332 Histone 2A 243339 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 243352 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 243362 GTPase-activator protein for Rho-like GTPases 243362 in StAR and phosphatidylcholine transfer protein 243362 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 243369 Thrombospondin type 1 repeats 243369 von Willebrand factor (vWF) type D domain 243369 Low-density lipoprotein receptor domain class A 243369 Thrombospondin type 1 repeats 243369 Coagulation factor 5/8 C-terminal domain, discoidin domain 243378 HAT (Half-A-TPR) repeats 243382 Serine/threonine phosphatases, family 2C, catalytic domain 243382 Serine/threonine phosphatases, family 2C, catalytic domain 243419 Immunoglobulin 243419 Immunoglobulin V-Type 243420 Immunoglobulin 243420 Immunoglobulin V-Type 243422 Immunoglobulin 243422 Immunoglobulin V-Type 243423 Immunoglobulin 243423 Immunoglobulin V-Type 243424 Immunoglobulin 243424 Immunoglobulin V-Type 243425 Immunoglobulin 243425 Immunoglobulin V-Type 243427 Actin 243428 Immunoglobulin 243428 Immunoglobulin V-Type 243428 Immunoglobulin C-2 Type 243429 Immunoglobulin 243429 Immunoglobulin V-Type 243430 Immunoglobulin 243430 Immunoglobulin V-Type 243431 Immunoglobulin 243431 Immunoglobulin V-Type 243432 Immunoglobulin 243432 Immunoglobulin V-Type 243433 Immunoglobulin 243433 Immunoglobulin V-Type 243434 Immunoglobulin 243434 Immunoglobulin V-Type 243436 Immunoglobulin 243436 Immunoglobulin V-Type 243436 Immunoglobulin C-2 Type 243437 Immunoglobulin 243437 Immunoglobulin V-Type 243438 Immunoglobulin 243438 Immunoglobulin V-Type 243438 Immunoglobulin C-2 Type 243439 Immunoglobulin 243439 Immunoglobulin V-Type 243439 Immunoglobulin C-2 Type 243440 Immunoglobulin 243440 Immunoglobulin V-Type 243441 Immunoglobulin 243441 Immunoglobulin V-Type 243442 Immunoglobulin 243442 Immunoglobulin V-Type 243444 Immunoglobulin 243444 Immunoglobulin V-Type 243445 Immunoglobulin 243445 Immunoglobulin V-Type 243446 Immunoglobulin 243446 Immunoglobulin V-Type 243448 Immunoglobulin 243448 Immunoglobulin V-Type 243449 Immunoglobulin 243449 Immunoglobulin V-Type 243450 Immunoglobulin 243450 Immunoglobulin V-Type 243451 Immunoglobulin 243451 Immunoglobulin V-Type 243455 Immunoglobulin 243455 Immunoglobulin V-Type 243456 Immunoglobulin 243456 Immunoglobulin V-Type 243457 Immunoglobulin 243457 Immunoglobulin V-Type 243457 Immunoglobulin C-2 Type 243458 Immunoglobulin 243458 Immunoglobulin V-Type 243459 Immunoglobulin 243459 Immunoglobulin V-Type 243459 Immunoglobulin C-2 Type 243460 Immunoglobulin 243460 Immunoglobulin V-Type 243460 Immunoglobulin C-2 Type 243461 Immunoglobulin 243461 Immunoglobulin V-Type 243462 Immunoglobulin 243462 Immunoglobulin V-Type 243463 Immunoglobulin 243463 Immunoglobulin V-Type 243465 Immunoglobulin 243465 Immunoglobulin V-Type 243465 Immunoglobulin C-2 Type 243467 Immunoglobulin 243467 Immunoglobulin V-Type 243468 Immunoglobulin 243468 Immunoglobulin V-Type 243469 Immunoglobulin 243469 Immunoglobulin V-Type 243474 Histone H3 243523 prohibitin homologues 243529 Domain in histone families 1 and 5 243547 Domain present in PSD-95, Dlg, and ZO-1/2 243547 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 243548 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 243548 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 243574 Kelch domain 243574 Broad-Complex, Tramtrack and Bric a brac 243621 Sec7 domain 243621 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 243645 ARF-like small GTPases 243645 Rab subfamily of small GTPases 243645 Ras subfamily of RAS small GTPases 243645 Rho (Ras homology) subfamily of Ras-like small GTPases 243645 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 243653 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 243655 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 243658 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 243659 Tyrosine kinase, catalytic domain 243664 Serine/Threonine protein kinases, catalytic domain 243676 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 243676 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 243676 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 243689 Rab subfamily of small GTPases 243689 Ras subfamily of RAS small GTPases 243715 domain involved in Ras-like GTPase signaling 243725 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 243725 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 243743 semaphorin domain 243743 ig-like, plexins, transcription factors 243743 domain found in Plexins, Semaphorins and Integrins 243743 ig-like, plexins, transcription factors 243743 GTPase-activator protein for Ras-like GTPases 243748 krueppel associated box 243771 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 243781 Immunoglobulin 243781 Immunoglobulin V-Type 243784 Immunoglobulin 243784 Immunoglobulin V-Type 243785 Immunoglobulin 243785 Immunoglobulin V-Type 243786 Immunoglobulin 243786 Immunoglobulin V-Type 243787 Immunoglobulin 243787 Immunoglobulin V-Type 243794 Immunoglobulin 243794 Immunoglobulin V-Type 243796 Domain present in VPS-27, Hrs and STAM 243801 Coagulation factor 5/8 C-terminal domain, discoidin domain 243802 Laminin G domain 243809 Laminin G domain 243811 snRNP Sm proteins 243813 zinc finger 243813 zinc finger 243821 RIO-like kinase 243821 Tyrosine kinase, catalytic domain 243821 erine/Threonine protein kinases, catalytic domain 243821 Serine/Threonine protein kinases, catalytic domain 243824 Tyrosine kinase, catalytic domain 243824 erine/Threonine protein kinases, catalytic domain 243824 Serine/Threonine protein kinases, catalytic domain 243831 krueppel associated box 243833 krueppel associated box 243833 krueppel associated box 243834 krueppel associated box 243834 krueppel associated box 243835 Cytoplasmic phospholipase A2, catalytic subunit 243849 Immunoglobulin 243849 Immunoglobulin C-2 Type 243862 Immunoglobulin 243862 Immunoglobulin C-2 Type 243863 Immunoglobulin 243863 Immunoglobulin C-2 Type 243864 Immunoglobulin C-Type 243865 K homology RNA-binding domain 243867 A Receptor for Ubiquitination Targets 243867 A Receptor for Ubiquitination Targets 243869 ankyrin repeats 243869 Src homology 3 domains 243874 Chromo Shadow Domain 243874 Leucine rich repeat, ribonuclease inhibitor type 243884 krueppel associated box 243902 krueppel associated box 243905 krueppel associated box 243906 krueppel associated box 243911 Immunoglobulin 243911 Immunoglobulin C-2 Type 243917 Uteroglobin 243948 krueppel associated box 243955 krueppel associated box 243956 krueppel associated box 243958 Immunoglobulin V-Type 243959 Trypsin-like serine protease 243961 Sterile alpha motif 243961 Src homology 3 domains 243961 Domain present in PSD-95, Dlg, and ZO-1/2 243961 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 243961 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 243963 krueppel associated box 243967 Netrin C-terminal Domain 243967 Laminin-type epidermal growth factor-like domai 243968 Tyrosine kinase, catalytic domain 243968 erine/Threonine protein kinases, catalytic domain 243968 Serine/Threonine protein kinases, catalytic domain 243973 Ubiquitin homologues 244000 zinc finger 244000 Ring finger 244030 Thrombospondin type 1 repeats 244049 Protein kinase C conserved region 2 (CalB) 244059 DEAD-like helicases superfamily 244059 Chromatin organization modifier domain 244059 helicase superfamily c-terminal domain 244061 Forkhead associated domain 244067 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 244067 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 244071 Zn_pept domain 244089 zinc finger 244091 B-Box C-terminal domain 244091 Fibronectin type 3 domain 244091 associated with SPRY domains 244091 Domain in SPla and the RYanodine Receptor. 244098 K homology RNA-binding domain 244099 high mobility group 244137 RNA recognition motif 244145 Broad-Complex, Tramtrack and Bric a brac 244153 snRNP Sm proteins 244153 Tyrosine kinase, catalytic domain 244153 Adenylyl- / guanylyl cyclase, catalytic domain 244153 erine/Threonine protein kinases, catalytic domain 244153 Serine/Threonine protein kinases, catalytic domain 244171 high mobility group 244178 Ubiquitin homologues 244178 Ubiquitin associated domain 244179 Ubiquitin homologues 244180 Olfactomedin-like domains 244183 Ring finger 244183 B-Box-type zinc finger 244199 Trypsin-like serine protease 244199 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 244220 von Willebrand factor (vWF) type A domain 244233 Scavenger receptor Cys-rich 244234 Scavenger receptor Cys-rich 244234 Scavenger receptor Cys-rich 244236 von Willebrand factor (vWF) type C domain 244236 C-terminal cystine knot-like domain (CTCK) 244236 von Willebrand factor (vWF) type D domain 244243 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 244292 Calponin homology domain 244321 Chromo Shadow Domain 244324 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 244324 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 244335 Domain in the RNA-binding Lupus La protein 244345 Domain present in PSD-95, Dlg, and ZO-1/2 244345 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 244349 PHD zinc finger 244371 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 244389 JAB/MPN domain 244417 Calcium-binding EGF-like domain 244417 Low-density lipoprotein-receptor YWTD domain 244417 Low-density lipoprotein receptor domain class A 244418 Serine/Threonine protein kinases, catalytic domain 244421 Ring finger 244428 domain present in cyclins, TFIIB and Retinoblastoma 244442 high mobility group 244443 ADAM Cysteine-Rich Domain 244443 Zinc-dependent metalloprotease 244443 Homologues of snake disintegrins 244448 associated with SPRY domains 244448 Domain in SPla and the RYanodine Receptor. 244448 Ring finger 244448 associated with SPRY domains 244448 Domain in SPla and the RYanodine Receptor. 244477 Immunoglobulin V-Type 244486 ADAM Cysteine-Rich Domain 244486 Homologues of snake disintegrins 244486 ADAM Cysteine-Rich Domain 244486 Homologues of snake disintegrins 244496 high mobility group 244516 Ligand binding domain of hormone receptors 244537 Domains in Na-Ca exchangers and integrin-beta4 244556 krueppel associated box 244579 high mobility group 244585 Protein kinase C conserved region 2 (CalB) 244585 Protein kinase C conserved region 2 (CalB) 244613 RNA recognition motif 244614 RRM_1 domain 244614 RNA recognition motif 244625 Serine/threonine phosphatases, family 2C, catalytic domain 244631 Serine/Threonine protein kinases, catalytic domain 244646 G-protein-coupled receptor proteolytic site domain 244646 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 244646 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 244647 Hint (Hedgehog/Intein) domain N-terminal region 244647 domain in Ataxins and HMG containing proteins 244648 Domain in the RNA-binding Lupus La protein 244650 Serine/threonine phosphatases, family 2C, catalytic domain 244668 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 244680 Fibronectin type 3 domain 244682 Immunoglobulin 244682 Immunoglobulin C-2 Type 244683 Immunoglobulin 244683 Immunoglobulin C-2 Type 244693 Small domain found in the jumonji family of transcription factors 244693 A domain family that is part of the cupin metalloenzyme superfamily 244693 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 244713 krueppel associated box 244714 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 244723 Olfactomedin-like domains 244723 Olfactomedin-like domains 244754 high mobility group 244758 ARF-like small GTPases 244763 Helix-turn-helix XRE-family like proteins 244810 Vault protein Inter-alpha-Trypsin domain 244810 von Willebrand factor (vWF) type A domain 244810 Vault protein Inter-alpha-Trypsin domain 244810 von Willebrand factor (vWF) type A domain 244811 In Between Ring fingers 244813 Homeodomain 244864 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 244885 Src homology 2 domains 244891 U1-like zinc finger 244893 In Between Ring fingers 244894 In Between Ring fingers 244917 high mobility group 244923 Kelch domain 244925 DEAD-like helicases superfamily 244925 helicase superfamily c-terminal domain 244954 Trypsin-like serine protease 244955 Homeodomain 244962 Domain associated with PX domains 244962 Regulator of G protein signalling domain 244967 ankyrin repeats 245000 Phosphoinositide 3-kinase, catalytic domain 245007 Broad-Complex, Tramtrack and Bric a brac 245010 EF-hand, calcium binding motif 245027 von Willebrand factor (vWF) type A domain 245038 Serine/Threonine protein kinases, catalytic domain 245050 krueppel associated box 245055 Immunoglobulin 245055 Immunoglobulin V-Type 245056 Histone H3 245068 erine/Threonine protein kinases, catalytic domain 245068 Serine/Threonine protein kinases, catalytic domain 245074 RIO-like kinase 245074 Tyrosine kinase, catalytic domain 245074 erine/Threonine protein kinases, catalytic domain 245074 Serine/Threonine protein kinases, catalytic domain 245075 Tyrosine kinase, catalytic domain 245075 erine/Threonine protein kinases, catalytic domain 245075 Serine/Threonine protein kinases, catalytic domain 245086 Immunoglobulin 245086 Immunoglobulin V-Type 245086 Immunoglobulin C-Type 245091 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 245093 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 245094 Immunoglobulin 245094 Immunoglobulin V-Type 245097 Immunoglobulin 245097 Immunoglobulin V-Type 245100 Immunoglobulin 245100 Immunoglobulin V-Type 245109 leucine rich region 245118 krueppel associated box 245126 Immunoglobulin 245126 Immunoglobulin 245126 Immunoglobulin C-2 Type 245132 Immunoglobulin 245132 Immunoglobulin V-Type 245137 Immunoglobulin 245137 Immunoglobulin V-Type 245138 Immunoglobulin 245138 Immunoglobulin V-Type 245143 RIO-like kinase 245143 Tyrosine kinase, catalytic domain 245143 erine/Threonine protein kinases, catalytic domain 245143 Serine/Threonine protein kinases, catalytic domain 245145 Immunoglobulin 245145 Immunoglobulin V-Type 245163 Immunoglobulin 245163 Immunoglobulin V-Type 245163 Immunoglobulin C-2 Type 245171 Immunoglobulin 245171 Immunoglobulin V-Type 245185 Tyrosine kinase, catalytic domain 245185 erine/Threonine protein kinases, catalytic domain 245185 Serine/Threonine protein kinases, catalytic domain 245187 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 245190 Leucine rich repeat C-terminal domain 245193 Metal dependent phosphohydrolases with conserved 'HD' motif 245193 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 245199 Immunoglobulin 245199 Immunoglobulin V-Type 245202 krueppel associated box 245208 krueppel associated box 245211 zinc finger 245218 Immunoglobulin 245218 Immunoglobulin V-Type 245238 Immunoglobulin 245238 Immunoglobulin V-Type 245239 Uteroglobin 245253 Immunoglobulin 245253 Immunoglobulin V-Type 245258 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 245263 Homeodomain 245266 Immunoglobulin 245266 Immunoglobulin V-Type 245269 Serine/Threonine protein kinases, catalytic domain 245269 Tyrosine kinase, catalytic domain 245269 erine/Threonine protein kinases, catalytic domain 245269 Serine/Threonine protein kinases, catalytic domain 245290 meprin and TRAF homology 245290 Broad-Complex, Tramtrack and Bric a brac 245293 Immunoglobulin 245293 Immunoglobulin V-Type 245295 Found in Skp1 protein family 245299 zinc finger 245317 Histone H3 245318 Histone H3 245335 Diacylglycerol kinase accessory domain (presumed) 245335 Diacylglycerol kinase catalytic domain (presumed) 245335 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 245350 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 245353 Histone 2A 245355 erine/Threonine protein kinases, catalytic domain 245355 Serine/Threonine protein kinases, catalytic domain 245368 krueppel associated box 245376 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 245376 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 245377 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 245403 WD40 repeats 245404 WD40 repeats 245418 Found in Pit-Oct-Unc transcription factors 245434 Histone H3 245446 Leucine rich repeat C-terminal domain 245450 Leucine rich repeat C-terminal domain 245453 FORKHEAD 245474 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 245483 helicase superfamily c-terminal domain 245484 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 245492 RNA recognition motif 245498 Zinc finger domain 245498 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 245521 Profilin 245545 RNA recognition motif 245548 Ring finger 245564 Homeodomain 245569 Fibronectin type 3 domain 245569 Bromodomain transcription factors and PHD domain containing proteins 245572 Domain first found in the mice T locus (Brachyury) protein 245572 Domain first found in the mice T locus (Brachyury) protein 245573 Armadillo/beta-catenin-like repeats 245574 zinc finger 245574 RNA recognition motif 245575 Domain in SPla and the RYanodine Receptor. 245578 Cadherin repeats 245578 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 245579 Histone 2A 245582 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 245583 Homeodomain 245596 Homeodomain 245598 K homology RNA-binding domain 245615 Immunoglobulin 245615 Immunoglobulin 245616 Immunoglobulin 245618 Protein tyrosine phosphatase, catalytic domain 245618 Protein tyrosine phosphatase, catalytic domain motif 245619 Tyrosine kinase, catalytic domain 245619 erine/Threonine protein kinases, catalytic domain 245619 Serine/Threonine protein kinases, catalytic domain 245638 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs 245638 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 245643 Band 4.1 homologues 245643 Band 4.1 homologues 245643 Domain present in PSD-95, Dlg, and ZO-1/2 245650 Tyrosine kinase, catalytic domain 245650 Adenylyl- / guanylyl cyclase, catalytic domain 245650 Juvenile hormone binding protein domains in insects 245650 erine/Threonine protein kinases, catalytic domain 245650 Serine/Threonine protein kinases, catalytic domain 245650 Juvenile hormone binding protein domains in insects. The juvenile hormone exerts pleiotropic functions during insect life cycles and its binding proteins regulate these functions 245663 prohibitin homologues 245666 Sec7 domain 245666 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 245670 ARF-like small GTPases 245670 Rab subfamily of small GTPases 245670 Ras subfamily of RAS small GTPases 245670 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 245683 Broad-Complex, Tramtrack and Bric a brac 245684 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 245684 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 245684 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 245684 Sterile alpha motif 245684 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 245684 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 245684 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 245685 Sterile alpha motif 245685 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 245694 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 245695 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 245708 Tyrosine kinase, catalytic domain 245708 Adenylyl- / guanylyl cyclase, catalytic domain 245709 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 245839 Trypsin-like serine protease 245857 Dual specificity phosphatase, catalytic domain 245869 Large family of predicted nucleotide-binding domains 245869 Large family of predicted nucleotide-binding domains 245881 DEAD-like helicases superfamily 245903 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 245903 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 245916 Cystatin-like domain 245919 Domain found in sea urchin sperm protein, enterokinase, agrin 245921 GS motif 245926 RNA recognition motif 245926 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 245945 RNA recognition motif 245945 RNA recognition motif 245955 Scavenger receptor Cys-rich 245956 Immunoglobulin V-Type 245977 Immunoglobulin 245977 G-protein-coupled receptor proteolytic site domain 245983 Immunoglobulin 245986 G protein gamma subunit-like motifs 246043 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 246073 FORKHEAD 246086 Homeodomain 246097 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 246097 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 246097 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 246138 Ly-6 antigen / uPA receptor -like domain 246147 Papain family cysteine protease 246149 Homeodomain 246152 WD40 repeats 246154 Leucine rich repeat C-terminal domain 246154 Leucine rich repeat N-terminal domain 246154 Leucine-rich repeats, typical (most populated) subfamily 246172 Immunoglobulin 246172 Immunoglobulin C-2 Type 246174 Protein present in Fab1, YOTB, Vac1, and EEA1 246174 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 246176 Calponin homology domain 246177 Myosin. Large ATPases. ATPase 246177 Myosin. Large ATPases 246177 Myosin. Large ATPases. ATPase 246186 Fibrinogen-related domains (FReDs) 246212 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 246214 Immunoglobulin 246214 Leucine rich repeat C-terminal domain 246216 Modified RING finger domain 246217 Src homology 3 domains 246237 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 246249 Src homology 3 domains 246249 GTPase-activator protein for Rho-like GTPases 246253 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 246254 LGN motif, putative GEFs specific for G-alpha GTPases 246256 Immunoglobulin 246264 krueppel associated box 246273 Serine/Threonine protein kinases, catalytic domain 246278 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 246293 Kelch domain 246296 Leucine rich repeat C-terminal domain 246297 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 246301 helix loop helix domain 246311 Serine/threonine phosphatases, family 2C, catalytic domain 246317 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 246325 Cyclic nucleotide-monophosphate binding domain 246329 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 246332 RNA recognition motif 246334 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 246381 Serine/Threonine protein kinases, catalytic domain 246707 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 246709 Regulator of G protein signalling domain 246710 Broad-Complex, Tramtrack and Bric a brac 246710 Rho (Ras homology) subfamily of Ras-like small GTPases 246746 Immunoglobulin 246757 Kelch domain 246775 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 246781 Protein tyrosine phosphatase, catalytic domain 252832 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 252833 Transforming growth factor-beta (TGF-beta) family 252834 Transforming growth factor-beta (TGF-beta) family 252838 high mobility group 252853 Helical region found in SNAREs 252856 helix loop helix domain 252860 leucine rich region 252860 krueppel associated box 252864 Dual specificity phosphatase, catalytic domain 252870 meprin and TRAF homology 252878 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 252879 Serine/Threonine protein kinases, catalytic domain 252882 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 252884 leucine rich region 252885 Homeodomain 252886 FORKHEAD 252888 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 252894 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 252895 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 252915 helix loop helix domain 252916 Rab subfamily of small GTPases 252920 Olfactomedin-like domains 252971 Src homology 2 domains 252971 suppressors of cytokine signalling 252974 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 253012 Immunoglobulin 253012 Immunoglobulin C-2 Type 253272 Ring finger 253289 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 253342 krueppel associated box 253558 Phosphate acyltransferases 253559 Immunoglobulin 253559 Immunoglobulin C-2 Type 253665 Ubiquitin homologues 253738 ig-like, plexins, transcription factors 253769 WD40 repeats 253782 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 253815 Zona pellucida (ZP) domain 253839 krueppel associated box 253853 krueppel associated box 253883 Immunoglobulin V-Type 253935 Fibrinogen-related domains (FReDs) 253935 Fibrinogen-related domains (FReDs) 253947 Immunoglobulin 253947 Immunoglobulin V-Type 253980 Broad-Complex, Tramtrack and Bric a brac 254065 bromo domain 254102 Calponin homology domain 254109 Rab subfamily of small GTPases 254109 Ras subfamily of RAS small GTPases 254109 Rho (Ras homology) subfamily of Ras-like small GTPases 254170 A Receptor for Ubiquitination Targets 254272 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 254556 Ring finger 254571 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 254573 Histone 2A 254665 Serine/Threonine protein kinases, catalytic domain 254953 Bruton's tyrosine kinase Cys-rich motif 254953 GTPase-activator protein for Ras-like GTPases 254953 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 254958 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 255189 Protein kinase C conserved region 2 (CalB) 255189 Cytoplasmic phospholipase A2, catalytic subunit 255239 ankyrin repeats 255239 Tyrosine kinase, catalytic domain 255239 Serine/Threonine protein kinases, catalytic domain 255290 GTPase-activator protein for Rho-like GTPases 255319 Putative GTP-ase activating proteins for the small GTPase, ARF 255319 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 255332 ARF-like small GTPases 255332 Sar1p-like members of the Ras-family of small GTPases 255426 Guanine nucleotide exchange factor for Ras-like small GTPases 255488 In Between Ring fingers 255519 high mobility group 255626 Histone H2B 255631 Fibrillar collagens C-terminal domain 255631 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 255743 Calcium-binding EGF-like domain 255743 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 255761 Epsin N-terminal homology (ENTH) domain 255877 Broad-Complex, Tramtrack and Bric a brac 255926 ADAM Cysteine-Rich Domain 255926 Homologues of snake disintegrins 255928 Protein kinase C conserved region 2 (CalB) 255992 Serine/Threonine protein kinases, catalytic domain 255997 krueppel associated box 256000 Rab subfamily of small GTPases 256000 Ras subfamily of RAS small GTPases 256000 Rho (Ras homology) subfamily of Ras-like small GTPases 256000 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 256006 ankyrin repeats 256076 von Willebrand factor (vWF) type A domain 256158 Immunoglobulin 256158 Immunoglobulin C-2 Type 256368 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 256372 RNA recognition motif 256380 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 256394 SERine Proteinase INhibitors 256401 Dual specificity phosphatase, catalytic domain 256401 Protein tyrosine phosphatase, catalytic domain 256401 Protein tyrosine phosphatase, catalytic domain motif 256447 krueppel associated box 256586 Lysin motif 256691 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 256710 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 256755 RNA recognition motif 256880 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 256949 ankyrin repeats 256970 Actin depolymerisation factor/cofilin -like domains 257067 14-3-3 homologues 257106 GTPase-activator protein for Rho-like GTPases 257106 GTPase-activator protein for Rho-like GTPases 257137 RNA recognition motif 257160 Ring finger 257194 Immunoglobulin 257194 Immunoglobulin C-2 Type 257218 Ring finger 257364 Src homology 3 domains 257397 Zinc finger domain 257408 Bruton's tyrosine kinase Cys-rich motif 257408 GTPase-activator protein for Ras-like GTPases 257629 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 257646 Band 4.1 homologues 258445 zinc finger 259172 Frizzled 259172 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 259197 Immunoglobulin V-Type 259218 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 259221 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 259229 Serine/threonine phosphatases, family 2C, catalytic domain 259230 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 259266 Calponin homology domain 259275 Src homology 3 domains 259277 Trypsin-like serine protease 259300 Eps15 homology domain 260296 Ring finger 260296 associated with SPRY domains 260296 Domain in SPla and the RYanodine Receptor. 260299 Immunoglobulin 260299 Immunoglobulin C-2 Type 260299 putative band 4.1 homologues' binding motif 260320 Trypsin-like serine protease 260320 Calcium-binding EGF-like domain 260320 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 260321 Tetratricopeptide repeats 260323 Band 4.1 homologues 260323 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 260324 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 260325 Homeodomain 260408 Trypsin-like serine protease 260409 P21-Rho-binding domain 260423 Histone H3 260425 Domain with 2 conserved Trp (W) residues 260425 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 260425 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 260425 Domain with 2 conserved Trp (W) residues 260425 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 260425 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 260429 Trypsin-like serine protease 261730 Serine/Threonine protein kinases, catalytic domain 263406 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 263803 Serine/Threonine protein kinases, catalytic domain 263803 Tyrosine kinase, catalytic domain 263803 Extension to Ser/Thr-type protein kinases 263803 erine/Threonine protein kinases, catalytic domain 263803 Serine/Threonine protein kinases, catalytic domain 264064 Serine/Threonine protein kinases, catalytic domain 266459 eukaryotic translation initiation factor 1A 266600 Cold shock protein domain 266608 Frizzled 266629 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 266631 RNA recognition motif 266632 Tyrosine kinase, catalytic domain 266632 erine/Threonine protein kinases, catalytic domain 266632 Serine/Threonine protein kinases, catalytic domain 266632 Tyrosine kinase, catalytic domain 266632 Serine/Threonine protein kinases, catalytic domain 266681 Trypsin-like serine protease 266692 von Willebrand factor (vWF) type A domain 266692 Protein kinase C conserved region 2 (CalB) 266692 von Willebrand factor (vWF) type A domain 266692 Protein kinase C conserved region 2 (CalB) 266704 Trypsin-like serine protease 266707 Connexin homologues 266707 domain present in cyclins, TFIIB and Retinoblastoma 266708 Trypsin-like serine protease 266714 Band 4.1 homologues 266714 Myosin. Large ATPases. ATPase 266714 Domain in Myosin and Kinesin Tails 266715 Frizzled 266727 Immunoglobulin 266734 PAS domain 266735 G-protein-coupled receptor proteolytic site domain 266735 G-protein-coupled receptor proteolytic site domain 266743 PAS domain 266743 PAS domain 266747 Guanine nucleotide exchange factor for Ras-like small GTPases 266765 Fibronectin type 3 domain 266765 LamG-like jellyroll fold domain 266765 Laminin N-terminal domain (domain VI) 266765 Laminin-type epidermal growth factor-like domai 266768 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 266772 Kelch domain 266775 SERine Proteinase INhibitors 266776 Cystatin-like domain 266777 Pentraxin / C-reactive protein / pentaxin family 266780 Src homology 3 domains 266781 Band 4.1 homologues 266815 Immunoglobulin C-Type 266815 Immunoglobulin C-Type 266976 Protein kinase C conserved region 2 (CalB) 266977 G-protein-coupled receptor proteolytic site domain 266997 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 268281 Ring finger 268281 helicase superfamily c-terminal domain 268291 In Between Ring fingers 268294 ATPases associated with a variety of cellular activities 268294 Broad-Complex, Tramtrack and Bric a brac 268299 PAS domain 268299 helix loop helix domain 268299 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 268319 zinc finger 268320 krueppel associated box 268321 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 268326 WD40 repeats 268329 Netrin C-terminal Domain 268329 Laminin N-terminal domain (domain VI) 268329 Laminin-type epidermal growth factor-like domai 268330 Ligand binding domain of hormone receptors 268330 c4 zinc finger in nuclear hormone receptors 268340 ATPases associated with a variety of cellular activities 268345 Broad-Complex, Tramtrack and Bric a brac 268360 Integrin alpha (beta-propellor repeats) 268396 Src homology 3 domains 268396 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 268396 Src homology 3 domains 268396 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 268398 delta serrate ligand 268398 Homologues of snake disintegrins 268402 Immunoglobulin 268402 Immunoglobulin V-Type 268406 Kinesin motor, catalytic domain. ATPase 268406 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 268415 Histone H2B 268417 leucine rich region 268424 Src homology 3 domains 268428 K homology RNA-binding domain 268448 PHD zinc finger 268467 prohibitin homologues 268474 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 268477 PHD zinc finger 268480 Guanine nucleotide exchange factor for Ras-like small GTPases 268484 Ubiquitin homologues 268493 Tetratricopeptide repeats 268495 domain found in Plexins, Semaphorins and Integrins 268495 Integrin beta subunits (N-terminal portion of extracellular region) 268497 Tyrosine kinase, catalytic domain 268497 Extension to Ser/Thr-type protein kinases 268497 Protein kinase C conserved region 2 (CalB) 268497 erine/Threonine protein kinases, catalytic domain 268497 Serine/Threonine protein kinases, catalytic domain 268497 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 268504 Immunoglobulin 268504 Immunoglobulin V-Type 268515 Bromo adjacent homology domain 268529 EF-hand, calcium binding motif 268534 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 268543 K homology RNA-binding domain 268564 Broad-Complex, Tramtrack and Bric a brac 268593 SERine Proteinase INhibitors 268597 Histone H3 268602 high mobility group 268604 Tyrosine kinase, catalytic domain 268604 Extension to Ser/Thr-type protein kinases 268604 erine/Threonine protein kinases, catalytic domain 268604 Serine/Threonine protein kinases, catalytic domain 268604 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 268612 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 268612 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 268623 Tudor domain 268623 ARID (A/T-rich interaction domain) domain 268657 snRNP Sm proteins 268663 Cadherin repeats 268663 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 268665 Thyroglobulin type I repeats 268665 Kazal type serine protease inhibitors 268665 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 268670 krueppel associated box 268687 GTPase-activator protein for Ras-like GTPases 268713 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 268729 Domain present in PSD-95, Dlg, and ZO-1/2 268729 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 268741 high mobility group 268741 high mobility group 268749 In Between Ring fingers 268752 WD40 repeats 268752 Protein present in Fab1, YOTB, Vac1, and EEA1 268766 high mobility group 268780 Laminin G domain 268780 Laminin G domain 268780 Fibronectin type 3 domain 268790 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 268790 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 268798 RNA recognition motif 268802 RNA recognition motif 268807 Kelch domain 268807 Broad-Complex, Tramtrack and Bric a brac 268818 Ly-6 antigen / uPA receptor -like domain 268831 Calponin homology domain 268845 U1-like zinc finger 268859 RRM_1 domain 268859 RNA recognition motif 268879 Orange domain 268879 helix loop helix domain 268884 Calcium-binding EGF-like domain 268886 Src homology 3 domains 268888 Immunoglobulin 268890 Immunoglobulin 268890 Immunoglobulin C-2 Type 268890 Immunoglobulin 268890 Immunoglobulin C-2 Type 268902 Immunoglobulin 268923 glycine rich nucleic binding domain 268930 Serine/Threonine protein kinases, catalytic domain 268932 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 268933 WD40 repeats 268935 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 268940 Homeodomain 268941 Calcium-binding EGF-like domain 268941 Domain found in Notch and Lin-12 268945 Immunoglobulin C-Type 268955 krueppel associated box 268958 Calpain-like thiol protease family 268958 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 268970 GTPase-activator protein for Rho-like GTPases 268977 Calcium-binding EGF-like domain 268977 Calcium-binding EGF-like domain 268977 Epidermal growth factor-like domain 268980 WD40 repeats 268992 high mobility group 269016 Ring finger 269016 Src homology 3 domains 269019 Serine/Threonine protein kinases, catalytic domain 269019 Tyrosine kinase, catalytic domain 269019 erine/Threonine protein kinases, catalytic domain 269019 Serine/Threonine protein kinases, catalytic domain 269036 Myosin. Large ATPases 269036 Myosin. Large ATPases. ATPase 269038 Middle domain of eukaryotic initiation factor 4G (eIF4G) 269047 Ligand binding domain of hormone receptors 269047 c4 zinc finger in nuclear hormone receptors 269049 calpain_III domain 269049 Calpain-like thiol protease family 269049 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 269061 RNA recognition motif 269064 DEAD-like helicases superfamily 269064 helicase superfamily c-terminal domain 269070 Ubiquitin homologues 269088 Homeodomain 269116 Immunoglobulin 269116 Immunoglobulin C-2 Type 269116 Fibronectin type 3 domain 269137 Domain abundant in complement control proteins 269140 Src homology 2 domains 269141 Immunoglobulin C-2 Type 269146 Pentraxin / C-reactive protein / pentaxin family 269173 Thrombospondin N-terminal -like domains 269173 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 269209 Serine/Threonine protein kinases, catalytic domain 269224 PAS domain 269224 Tyrosine kinase, catalytic domain 269224 erine/Threonine protein kinases, catalytic domain 269224 Serine/Threonine protein kinases, catalytic domain 269243 Tyrosine kinase, catalytic domain 269243 Serine/Threonine protein kinases, catalytic domain 269261 Ribosomal protein L11/L12 269261 Ribosomal protein L11/L12 269267 Ubiquitin homologues 269275 Tyrosine kinase, catalytic domain 269275 erine/Threonine protein kinases, catalytic domain 269275 Serine/Threonine protein kinases, catalytic domain 269278 Rab subfamily of small GTPases 269278 Ras subfamily of RAS small GTPases 269278 Rho (Ras homology) subfamily of Ras-like small GTPases 269282 Tyrosine kinase, catalytic domain 269282 erine/Threonine protein kinases, catalytic domain 269282 Serine/Threonine protein kinases, catalytic domain 269285 Immunoglobulin 269285 Immunoglobulin C-2 Type 269316 Immunoglobulin 269316 Immunoglobulin C-2 Type 269316 Fibronectin type 3 domain 269319 Ligase N family 269325 Broad-Complex, Tramtrack and Bric a brac 269338 Clathrin heavy chain repeat homology 269338 Clathrin heavy chain repeat homology 269338 Clathrin heavy chain repeat homology 269338 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 269354 Transglutaminase/protease-like homologues 269361 high mobility group 269380 Hemopexin-like repeats 269380 Zinc-dependent metalloprotease 269380 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 269384 BPI/LBP/CETP C-terminal domain 269384 BPI/LBP/CETP N-terminal domain 269400 DEAD-like helicases superfamily 269400 helicase superfamily c-terminal domain 269406 Tyrosine kinase, catalytic domain 269406 erine/Threonine protein kinases, catalytic domain 269406 Serine/Threonine protein kinases, catalytic domain 269415 Myosin. Large ATPases 269415 Myosin. Large ATPases. ATPase 269425 DnaJ molecular chaperone homology domain 269427 GTPase-activator protein for Rho-like GTPases 269452 Immunoglobulin 269452 Immunoglobulin V-Type 269452 Link (Hyaluronan-binding) 269452 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 269470 WD40 repeats 269473 Immunoglobulin 269473 Immunoglobulin C-2 Type 269473 Leucine rich repeat C-terminal domain 269487 Alpha-amylase domain 269497 Src homology 2 domains 269497 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 269504 Calcium-binding EGF-like domain 269504 G-protein-coupled receptor proteolytic site domain 269511 high mobility group 269514 Leucine-rich repeat - CC (cysteine-containing) subfamily 269523 ATPases associated with a variety of cellular activities 269523 ATPases associated with a variety of cellular activities 269527 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 269527 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 269529 A Receptor for Ubiquitination Targets 269533 Sterile alpha motif 269533 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 269540 zinc finger 269541 Domain present in PSD-95, Dlg, and ZO-1/2 269541 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 269546 Large family of predicted nucleotide-binding domains 269587 Band 4.1 homologues 269589 Protein kinase C conserved region 2 (CalB) 269594 RNA recognition motif 269608 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 269608 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 269615 Phospholipase C, catalytic domain (part) 269615 Phospholipase C, catalytic domain (part) 269615 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 269622 S4 RNA-binding domain 269635 breast cancer carboxy-terminal domain 269636 Homeodomain 269691 14-3-3 homologues 269697 Homeodomain 269697 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 269697 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 269700 Domain Homologous to E6-AP Carboxyl Terminus with 269700 Domain Homologous to E6-AP Carboxyl Terminus with 269709 Tyrosine kinase, catalytic domain 269709 erine/Threonine protein kinases, catalytic domain 269709 Serine/Threonine protein kinases, catalytic domain 269740 Homeodomain 269754 Src homology 3 domains 269756 Immunoglobulin 269756 Immunoglobulin V-Type 269757 Immunoglobulin 269757 Immunoglobulin V-Type 269765 high mobility group 269772 Annexin repeats 269773 Serine/Threonine protein kinases, catalytic domain 269784 Immunoglobulin 269784 Immunoglobulin C-2 Type 269792 Histone H3 269799 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 269807 Low-density lipoprotein-receptor YWTD domain 269807 Low-density lipoprotein receptor domain class A 269819 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 269836 von Willebrand factor (vWF) type C domain 269836 von Willebrand factor (vWF) type D domain 269845 krueppel associated box 269846 Immunoglobulin C-Type 269855 Scavenger receptor Cys-rich 269857 SERine Proteinase INhibitors 269859 Dual specificity phosphatase, catalytic domain 269863 zinc finger 269864 WD40 repeats 269870 leucine rich region 269870 leucine rich region 269870 krueppel associated box 269877 erythroblast transformation specific domain 269881 Tyrosine kinase, catalytic domain 269881 erine/Threonine protein kinases, catalytic domain 269881 Serine/Threonine protein kinases, catalytic domain 269886 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 269886 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 269894 bromo domain 269894 PHD zinc finger 269905 Trypsin-like serine protease 269906 Trypsin-like serine protease 269907 Trypsin-like serine protease 269928 Armadillo/beta-catenin-like repeats 269932 Src homology 2 domains 269932 Src homology 3 domains 269939 Src homology 3 domains 269939 Guanylate kinase homologues 269939 Domain present in PSD-95, Dlg, and ZO-1/2 269939 Domain present in ZO-1 and Unc5-like netrin receptors 269939 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 269939 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 269945 Immunoglobulin 269945 Immunoglobulin V-Type 269945 Link (Hyaluronan-binding) 269945 Domain abundant in complement control proteins 269945 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 269949 helix loop helix domain 269957 Immunoglobulin 269957 Immunoglobulin C-2 Type 269959 Immunoglobulin 269959 Immunoglobulin C-2 Type 269997 krueppel associated box 269997 krueppel associated box 270000 erine/Threonine protein kinases, catalytic domain 270000 Serine/Threonine protein kinases, catalytic domain 270004 FORKHEAD 270014 RIO-like kinase 270014 Tyrosine kinase, catalytic domain 270014 erine/Threonine protein kinases, catalytic domain 270014 Serine/Threonine protein kinases, catalytic domain 270055 Link (Hyaluronan-binding) 270055 Calcium-binding EGF-like domain 270055 Domain abundant in complement control proteins 270055 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 270056 Metal dependent phosphohydrolases with conserved 'HD' motif 270056 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 270057 Fibronectin type 3 domain 270082 Complement component C1q domain 270082 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 270083 zinc finger 270086 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 270086 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 270105 Cadherin repeats 270105 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 270112 Coagulation factor 5/8 C-terminal domain, discoidin domain 270112 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein 270112 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 270112 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 270149 Zona pellucida (ZP) domain 270149 von Willebrand factor (vWF) type D domain 270149 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 270152 Immunoglobulin 270152 Immunoglobulin V-Type 270160 Rab subfamily of small GTPases 270160 ARF-like small GTPases 270160 Rab subfamily of small GTPases 270160 Ras subfamily of RAS small GTPases 270160 Sar1p-like members of the Ras-family of small GTPases 270160 Rho (Ras homology) subfamily of Ras-like small GTPases 270160 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 270163 GTPase-activator protein for Rho-like GTPases 270164 ARF-like small GTPases 270164 Sar1p-like members of the Ras-family of small GTPases 270166 ATPases associated with a variety of cellular activities 270186 Histone H3 270190 Fibronectin type 3 domain 270190 Tyrosine kinase, catalytic domain 270192 ARF-like small GTPases 270192 Rab subfamily of small GTPases 270192 Ras subfamily of RAS small GTPases 270192 Rho (Ras homology) subfamily of Ras-like small GTPases 270192 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 270201 Kelch domain 270226 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 270230 Histone H3 270243 glycine rich nucleic binding domain 270319 Broad-Complex, Tramtrack and Bric a brac 270344 Homeodomain 270384 Immunoglobulin 270384 Immunoglobulin V-Type 270386 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 270392 Baculoviral inhibition of apoptosis protein repeat 270417 Laminin N-terminal domain (domain VI) 270417 Laminin-type epidermal growth factor-like domai 270417 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 270417 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 270425 Immunoglobulin 270425 Immunoglobulin V-Type 270437 krueppel associated box 270468 Immunoglobulin 270468 Immunoglobulin V-Type 270500 RNA recognition motif 270506 Pancreatic ribonuclease 270526 RNA polymerases D 270529 Tyrosine kinase, catalytic domain 270529 erine/Threonine protein kinases, catalytic domain 270529 Serine/Threonine protein kinases, catalytic domain 270589 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 270589 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 270596 EF-hand, calcium binding motif 270600 DEAD-like helicases superfamily 270627 bromo domain 270636 Rab subfamily of small GTPases 270636 Ras subfamily of RAS small GTPases 270636 Rho (Ras homology) subfamily of Ras-like small GTPases 270636 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 270637 Ribosomal protein L11/L12 270665 high mobility group 270667 Ring finger 270670 Ubiquitin homologues 270672 Tyrosine kinase, catalytic domain 270672 erine/Threonine protein kinases, catalytic domain 270672 Serine/Threonine protein kinases, catalytic domain 270749 Trypsin-like serine protease 270749 Low-density lipoprotein receptor domain class A 270757 BPI/LBP/CETP C-terminal domain 270757 BPI/LBP/CETP N-terminal domain 270763 Band 4.1 homologues 270764 Sterile alpha motif 270764 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 270784 RNA recognition motif 270804 Serine/threonine phosphatases, family 2C, catalytic domain 270997 Homeodomain 271003 Immunoglobulin 271003 Immunoglobulin C-2 Type 271021 Histone H3 271022 eukaryotic translation initiation factor 1A 271048 SERine Proteinase INhibitors 271068 Immunoglobulin 271068 Immunoglobulin V-Type 271124 krueppel associated box 271127 Thrombospondin type 1 repeats 271133 high mobility group 271202 high mobility group 271209 Domain in the Doublecortin (DCX) gene product 271264 ig-like, plexins, transcription factors 271268 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 271280 WD40 repeats 271305 PHD zinc finger 271364 Calponin homology domain 271374 RNA recognition motif 271387 WD40 repeats 271395 Kinesin motor, catalytic domain. ATPase 271395 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 271409 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 271415 krueppel associated box 271427 Src homology 3 domains 271427 Fes/CIP4 homology domain 271444 Immunoglobulin C-Type 271451 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 271490 Armadillo/beta-catenin-like repeats 271501 Splicing Factor Motif, present in Prp18 and Pr04 271505 Cold shock protein domain 271508 bromo domain 271508 bromo domain 271521 GTPase-activator protein for Rho-like GTPases 271697 Tyrosine kinase, catalytic domain 271697 erine/Threonine protein kinases, catalytic domain 271697 Serine/Threonine protein kinases, catalytic domain 271707 Tyrosine kinase, catalytic domain 271707 erine/Threonine protein kinases, catalytic domain 271707 Serine/Threonine protein kinases, catalytic domain 271786 Ricin-type beta-trefoil 271813 Zn_pept domain 271813 Zn_pept domain 271844 Protein kinase C conserved region 2 (CalB) 271844 Cytoplasmic phospholipase A2, catalytic subunit 271919 Domain in the RNA-binding Lupus La protein 271944 Protein kinase C conserved region 2 (CalB) 271981 Serine/Threonine protein kinases, catalytic domain 271981 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 272009 RNA recognition motif 272039 Calcium-binding EGF-like domain 272063 erine/Threonine protein kinases, catalytic domain 272129 Ring finger 272144 G protein alpha subunit 272155 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 272158 DNA polymerase A domain 272284 Tyrosine kinase, catalytic domain 272284 erine/Threonine protein kinases, catalytic domain 272284 Serine/Threonine protein kinases, catalytic domain 272311 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 272322 PAS domain 272339 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 272341 Trypsin-like serine protease 272347 krueppel associated box 272347 krueppel associated box 272350 Galectin 272378 krueppel associated box 272381 Immunoglobulin 272381 Immunoglobulin C-2 Type 272381 Leucine rich repeat C-terminal domain 272382 erythroblast transformation specific domain 272391 high mobility group 272417 Dual specificity phosphatase, catalytic domain 272422 high mobility group 272462 ATPases associated with a variety of cellular activities 272636 Protein kinase C conserved region 2 (CalB) 272643 Trypsin-like serine protease 272667 RIO-like kinase 272667 Tyrosine kinase, catalytic domain 272667 erine/Threonine protein kinases, catalytic domain 272667 Serine/Threonine protein kinases, catalytic domain 272671 eukaryotic translation initiation factor 1A 272673 RNA recognition motif 272677 HAT (Half-A-TPR) repeats 272680 RIO-like kinase 272680 Tyrosine kinase, catalytic domain 272680 erine/Threonine protein kinases, catalytic domain 272680 Serine/Threonine protein kinases, catalytic domain 272683 Immunoglobulin 272683 Immunoglobulin V-Type 272684 high mobility group 272691 S4 RNA-binding domain 272692 eukaryotic translation initiation factor 1A 272699 eukaryotic translation initiation factor 1A 272740 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 272771 glycine rich nucleic binding domain 276756 Histidine kinase-like ATPases 276792 Thymosin beta actin-binding motif 276829 Calponin homology domain 276829 Calponin homology domain 276837 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 276891 Immunoglobulin 276891 Immunoglobulin 276905 Armadillo/beta-catenin-like repeats 276925 Ubiquitin homologues 276929 Tudor domain 276929 K homology RNA-binding domain 276941 RNA recognition motif 276998 RNA recognition motif 277016 DEAD-like helicases superfamily 277016 helicase superfamily c-terminal domain 277027 RNA recognition motif 277035 erine/Threonine protein kinases, catalytic domain 277035 Serine/Threonine protein kinases, catalytic domain 277047 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 277047 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 277049 eukaryotic translation initiation factor 1A 277051 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 277055 Immunoglobulin V-Type 277068 Immunoglobulin V-Type 277069 Immunoglobulin 277069 Immunoglobulin V-Type 277071 Immunoglobulin V-Type 277089 EF-hand, calcium binding motif 277097 SERine Proteinase INhibitors 277099 Histone H4 277111 Histone H3 277135 Immunoglobulin 277135 Immunoglobulin V-Type 277136 Immunoglobulin 277136 Immunoglobulin V-Type 277137 Immunoglobulin 277137 Immunoglobulin V-Type 277145 Immunoglobulin 277145 Immunoglobulin V-Type 277146 Immunoglobulin 277146 Immunoglobulin V-Type 277147 Immunoglobulin 277147 Immunoglobulin V-Type 277148 Immunoglobulin 277148 Immunoglobulin V-Type 277149 Immunoglobulin 277149 Immunoglobulin V-Type 277151 Immunoglobulin 277151 Immunoglobulin V-Type 277161 glycine rich nucleic binding domain 277164 Pancreatic ribonuclease 277258 AN1-like Zinc finger 277258 Putative single-stranded nucleic acids-binding domain 277313 RNA recognition motif 277328 ankyrin repeats 277339 Ribosomal protein L11/L12 277343 BPTI/Kunitz family of serine protease inhibitors 277343 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 277395 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 277395 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 277396 Kelch domain 277396 Kelch domain 277396 Broad-Complex, Tramtrack and Bric a brac 277432 Immunoglobulin 277481 Integrin alpha (beta-propellor repeats) 277481 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 277577 krueppel associated box 277603 RNA recognition motif 277636 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 277657 Rab subfamily of small GTPases 277657 Ras subfamily of RAS small GTPases 277657 Rho (Ras homology) subfamily of Ras-like small GTPases 277704 Sterile alpha motif 277704 Fibronectin type 3 domain 277704 Tyrosine kinase, catalytic domain 277704 Ephrin receptor ligand binding domain 277704 erine/Threonine protein kinases, catalytic domain 277704 Serine/Threonine protein kinases, catalytic domain 277704 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 277807 Rab subfamily of small GTPases 277807 Ras subfamily of RAS small GTPases 277807 Rho (Ras homology) subfamily of Ras-like small GTPases 277807 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 277854 Domain found in Dishevelled, Egl-10, and Pleckstrin 277860 Ring finger 277860 PHD zinc finger 277860 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533 277860 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. Domain in SET domain containing proteins and in Deinococcus radiodurans DRA1533 277892 erine/Threonine protein kinases, catalytic domain 277892 Serine/Threonine protein kinases, catalytic domain 277905 Immunoglobulin 277905 Immunoglobulin V-Type 277910 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 277943 Uteroglobin 277979 Rab subfamily of small GTPases 277979 Ras subfamily of RAS small GTPases 277979 Rho (Ras homology) subfamily of Ras-like small GTPases 278103 high mobility group 278125 tob/btg1 family 278174 krueppel associated box 278179 zinc finger 278180 Immunoglobulin V-Type 278180 Immunoglobulin V-Type 278188 WD40 repeats 278192 DEAD-like helicases superfamily 278203 Alpha-lactalbumin / lysozyme C 278209 Middle domain of eukaryotic initiation factor 4G (eIF4G) 278214 glycine rich nucleic binding domain 278215 Ring finger 278232 Protein kinase C conserved region 2 (CalB) 278248 krueppel associated box 278263 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 278263 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 278279 Tetratricopeptide repeats 278304 U1-like zinc finger 278473 Myosin. Large ATPases. ATPase 278473 Myosin. Large ATPases 278473 Myosin. Large ATPases. ATPase 278507 Immunoglobulin 278507 Kazal type serine protease inhibitors 278507 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 278507 Immunoglobulin 278507 Immunoglobulin C-2 Type 278507 Kazal type serine protease inhibitors 278507 BPTI/Kunitz family of serine protease inhibitors 278507 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 278581 Immunoglobulin 278581 Immunoglobulin V-Type 278583 Immunoglobulin 278583 Immunoglobulin V-Type 278603 Immunoglobulin 278603 Immunoglobulin V-Type 278616 WD40 repeats 278666 Immunoglobulin 278666 Immunoglobulin V-Type 278668 Immunoglobulin V-Type 278672 Homeodomain 278725 Immunoglobulin 278725 Immunoglobulin C-2 Type 278748 zinc finger 278757 krueppel associated box 278791 Fibronectin type 3 domain 278986 GTPase-activator protein for Rho-like GTPases 279028 Thrombospondin type 1 repeats 279029 Tyrosine kinase, catalytic domain 279029 Serine/Threonine protein kinases, catalytic domain 279029 erine/Threonine protein kinases, catalytic domain 279056 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 279057 krueppel associated box 279071 krueppel associated box 279184 Rab subfamily of small GTPases 279184 Ras subfamily of RAS small GTPases 279184 Rho (Ras homology) subfamily of Ras-like small GTPases 279184 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 279230 Found in Skp1 protein family 279260 Rab subfamily of small GTPases 279260 Ras subfamily of RAS small GTPases 279260 Rho (Ras homology) subfamily of Ras-like small GTPases 279333 Tyrosine kinase, catalytic domain 279333 erine/Threonine protein kinases, catalytic domain 279333 Serine/Threonine protein kinases, catalytic domain 279387 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases 279429 Immunoglobulin 279429 Immunoglobulin V-Type 279430 Immunoglobulin 279430 Immunoglobulin V-Type 279431 Immunoglobulin 279431 Immunoglobulin V-Type 279432 Immunoglobulin 279432 Immunoglobulin V-Type 279472 krueppel associated box 279475 high mobility group 279499 Broad-Complex, Tramtrack and Bric a brac 279553 Homeodomain 279554 Homeodomain 279572 Toll - interleukin 1 - resistance 279610 Homeodomain 279643 Broad-Complex, Tramtrack and Bric a brac 279653 Cadherin repeats 279656 high mobility group 279679 prohibitin homologues 279730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 279838 Immunoglobulin 279838 Immunoglobulin V-Type 279851 Immunoglobulin 279851 Immunoglobulin V-Type 279857 Immunoglobulin 279857 Immunoglobulin V-Type 279872 Immunoglobulin 279872 Immunoglobulin V-Type 279872 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 279881 Immunoglobulin 279881 Immunoglobulin V-Type 279882 Immunoglobulin 279882 Immunoglobulin V-Type 279887 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 279896 Tyrosine kinase, catalytic domain 279896 erine/Threonine protein kinases, catalytic domain 279896 Serine/Threonine protein kinases, catalytic domain 279922 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 279922 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 279923 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) 279923 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 279934 Broad-Complex, Tramtrack and Bric a brac 279939 Immunoglobulin C-Type 279991 krueppel associated box 280078 Small MutS-related domain 280219 Immunoglobulin 280219 Immunoglobulin V-Type 280413 Integrin alpha (beta-propellor repeats) 280413 von Willebrand factor (vWF) type A domain 280458 DEAD-like helicases superfamily 280458 helicase superfamily c-terminal domain 280487 glycine rich nucleic binding domain 280657 krueppel associated box 280658 krueppel associated box 280659 krueppel associated box 280660 krueppel associated box 280667 ADAM Cysteine-Rich Domain 280667 Homologues of snake disintegrins 280668 ADAM Cysteine-Rich Domain 280668 Homologues of snake disintegrins 282582 found in Wnt-1 282587 ankyrin repeats 282635 zinc finger 282663 SERine Proteinase INhibitors 282708 serum albumin 282824 RNA recognition motif 282824 RNA recognition motif 282833 P or trefoil or TFF domain 282838 Repeats found in several Drosophila proteins 282840 basic region leucin zipper 282843 Sorbin homologous domain 282890 krueppel associated box 282898 DEAD-like helicases superfamily 282911 Immunoglobulin C-Type 282927 krueppel associated box 282935 DEAD-like helicases superfamily 282959 Immunoglobulin C-Type 282974 Serine/Threonine protein kinases, catalytic domain 282984 Actin 282985 von Willebrand factor (vWF) type A domain 282998 ankyrin repeats 282998 Putative GTP-ase activating proteins for the small GTPase, ARF 283002 ankyrin repeats 283002 Putative GTP-ase activating proteins for the small GTPase, ARF 283011 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 283011 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 283018 ankyrin repeats 283018 Putative GTP-ase activating proteins for the small GTPase, ARF 283018 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 283021 Putative GTP-ase activating proteins for the small GTPase, ARF 283021 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 283037 ankyrin repeats 283037 Putative GTP-ase activating proteins for the small GTPase, ARF 283039 Homeodomain 283043 ankyrin repeats 283043 Putative GTP-ase activating proteins for the small GTPase, ARF 283044 Putative GTP-ase activating proteins for the small GTPase, ARF 283044 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 283054 Annexin repeats 283078 Homeodomain 283116 Ring finger 283116 Domain in SPla and the RYanodine Receptor. 283117 Ring finger 283117 Domain in SPla and the RYanodine Receptor. 283150 FORKHEAD 283155 Tyrosine kinase, catalytic domain 283155 Serine/Threonine protein kinases, catalytic domain 283158 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 283181 Domain in SPla and the RYanodine Receptor. 283202 krueppel associated box 283208 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 283208 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 283212 Kelch domain 283219 Broad-Complex, Tramtrack and Bric a brac 283248 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 283256 Domain in SPla and the RYanodine Receptor. 283257 Domain in SPla and the RYanodine Receptor. 283258 Domain in SPla and the RYanodine Receptor. 283259 Ring finger 283259 Domain in SPla and the RYanodine Receptor. 283284 Immunoglobulin 283284 Fibronectin type 3 domain 283298 Olfactomedin-like domains 283310 C-terminal cystine knot-like domain (CTCK) 283316 Scavenger receptor Cys-rich 283321 krueppel associated box 283326 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 283342 Histone H3 283349 Ras association (RalGDS/AF-6) domain 283368 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 283377 Domain in SPla and the RYanodine Receptor. 283419 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 283420 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 283425 Found in Skp1 protein family 283431 Calponin homology domain 283465 RNA recognition motif 283465 K homology RNA-binding domain 283471 Trypsin-like serine protease 283471 Trypsin-like serine protease 283510 Diacylglycerol kinase accessory domain (presumed) 283510 Diacylglycerol kinase catalytic domain (presumed) 283510 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 283523 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 283539 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 283549 DnaJ molecular chaperone homology domain 283629 Serine/Threonine protein kinases, catalytic domain 283653 domain in TBC and LysM domain containing proteins 283660 Immunoglobulin 283660 Immunoglobulin C-2 Type 283716 Cyclic nucleotide-monophosphate binding domain 283741 Homeodomain 283747 Found in Skp1 protein family 283754 Serine/Threonine protein kinases, catalytic domain 283756 Immunoglobulin 283756 Immunoglobulin V-Type 283757 Immunoglobulin 283757 Immunoglobulin V-Type 283804 ADAM Cysteine-Rich Domain 283804 Homologues of snake disintegrins 283805 Immunoglobulin V-Type 283806 Tyrosine kinase, catalytic domain 283806 Serine/Threonine protein kinases, catalytic domain 283912 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 283925 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 283940 GTPase-activator protein for Rho-like GTPases 283955 Lipoxygenase homology 2 (beta barrel) domain 283955 G-protein-coupled receptor proteolytic site domain 283971 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 284007 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 284054 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 284057 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 284086 Serine/Threonine protein kinases, catalytic domain 284086 Tyrosine kinase, catalytic domain 284086 Serine/Threonine protein kinases, catalytic domain 284087 Actin depolymerisation factor/cofilin -like domains 284100 14-3-3 homologues 284106 CDGSH-type zinc finger. Function unknown 284121 ankyrin repeats 284164 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 284166 Ribosomal protein L11/L12 284200 Tyrosine kinase, catalytic domain 284200 Serine/Threonine protein kinases, catalytic domain 284201 Ring finger 284217 Laminin G domain 284217 Laminin N-terminal domain (domain VI) 284217 Laminin-type epidermal growth factor-like domai 284228 ankyrin repeats 284235 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 284252 Broad-Complex, Tramtrack and Bric a brac 284268 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 284287 snRNP Sm proteins 284293 SERine Proteinase INhibitors 284299 Tyrosine kinase, catalytic domain 284299 Serine/Threonine protein kinases, catalytic domain 284301 Ring finger 284301 associated with SPRY domains 284301 Domain in SPla and the RYanodine Receptor. 284302 leucine rich region 284306 krueppel associated box 284307 krueppel associated box 284312 leucine rich region 284312 leucine rich region 284318 krueppel associated box 284319 WASP homology region 1 284323 krueppel associated box 284335 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 284341 A20-like zinc fingers 284344 Immunoglobulin 284344 Immunoglobulin C-2 Type 284345 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 284358 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 284366 Trypsin-like serine protease 284367 Immunoglobulin V-Type 284382 Actin 284382 Actin 284387 RNA recognition motif 284390 krueppel associated box 284391 krueppel associated box 284406 krueppel associated box 284434 WD40 repeats 284441 Actin 284459 krueppel associated box 284459 krueppel associated box 284479 Src homology 3 domains 284500 Aamy_C domain 284509 helix loop helix domain 284525 Cyclic nucleotide-monophosphate binding domain 284545 high mobility group 284597 Kelch domain 284613 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the t 284613 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 284615 ankyrin repeats 284642 ARID (A/T-rich interaction domain) domain 284651 Toll - interleukin 1 - resistance 284652 Domain abundant in complement control proteins 284652 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 284683 high mobility group 284685 RNA recognition motif 284689 Ubiquitin homologues 284696 Xeroderma pigmentosum G N-region 284697 Broad-Complex, Tramtrack and Bric a brac 284759 Immunoglobulin 284759 Immunoglobulin V-Type 284759 Immunoglobulin C-2 Type 284766 S4 RNA-binding domain 284767 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 284813 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 284850 Actin 284948 Src homology 2 domains 284967 Trypsin-like serine protease 284988 Rho (Ras homology) subfamily of Ras-like small GTPases 285011 RNA recognition motif 285025 Immunoglobulin 285031 high mobility group 285046 RNA recognition motif 285101 GTPase-activator protein for Rho-like GTPases 285112 RNA recognition motif 285180 Protein present in Fab1, YOTB, Vac1, and EEA1 285189 divergent subfamily of APPLE domains 285190 Tetratricopeptide repeats 285190 Ran-binding domain 285190 Tetratricopeptide repeats 285193 Dual specificity phosphatase, catalytic domain 285220 Tyrosine kinase, catalytic domain 285227 high mobility group 285268 krueppel associated box 285280 Leucine rich repeat N-terminal domain 285280 Leucine rich repeat C-terminal domain 285282 Rab subfamily of small GTPases 285292 RNA recognition motif 285301 krueppel associated box 285313 Immunoglobulin 285313 Immunoglobulin C-2 Type 285313 Immunoglobulin 285313 Immunoglobulin C-2 Type 285320 Chromo Shadow Domain 285329 Ubiquitin homologues 285329 Ubiquitin associated domain 285335 Cyclic nucleotide-monophosphate binding domain 285358 Homeodomain 285373 Tyrosine kinase, catalytic domain 285373 Serine/Threonine protein kinases, catalytic domain 285405 Actin 285412 high mobility group 285426 RNA recognition motif 285434 Helical region found in SNAREs 285484 high mobility group 285507 RNA recognition motif 285532 WD40 repeats 285562 Histone H3 285590 Src homology 3 domains 285590 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 285643 DNA Topoisomerase I (eukaryota) 285643 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 285671 Ring finger 285676 krueppel associated box 285676 krueppel associated box 285728 high mobility group 285732 14-3-3 homologues 285761 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 285788 Tyrosine kinase, catalytic domain 285788 Serine/Threonine protein kinases, catalytic domain 285809 Src homology 3 domains 285829 Ubiquitin homologues 285897 Bromo adjacent homology domain 285918 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 285929 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 285934 helix loop helix domain 285940 Tyrosine kinase, catalytic domain 285940 Serine/Threonine protein kinases, catalytic domain 285969 krueppel associated box 285984 RNA recognition motif 286000 RNA recognition motif 286017 Tyrosine kinase, catalytic domain 286017 Serine/Threonine protein kinases, catalytic domain 286061 Src homology 3 domains 286075 krueppel associated box 286106 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 286136 Tyrosine kinase, catalytic domain 286136 Serine/Threonine protein kinases, catalytic domain 286140 Ring finger 286157 K homology RNA-binding domain 286220 helix loop helix domain 286228 DEAD-like helicases superfamily 286246 Rab subfamily of small GTPases 286246 Ras subfamily of RAS small GTPases 286246 Rho (Ras homology) subfamily of Ras-like small GTPases 286380 FORKHEAD 286398 RNA recognition motif 286420 ARF-like small GTPases 286420 Sar1p-like members of the Ras-family of small GTPases 286436 Histone H2B 286472 Rab subfamily of small GTPases 286472 Ras subfamily of RAS small GTPases 286472 Rho (Ras homology) subfamily of Ras-like small GTPases 286472 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 286474 Ubiquitin homologues 286480 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 286487 14-3-3 homologues 286488 Tyrosine kinase, catalytic domain 286488 Serine/Threonine protein kinases, catalytic domain 286494 Tyrosine kinase, catalytic domain 286494 Serine/Threonine protein kinases, catalytic domain 286495 Ring finger 286512 DEAD-like helicases superfamily 286526 ARF-like small GTPases 286526 Rab subfamily of small GTPases 286526 suppressors of cytokine signalling 286526 Ras subfamily of RAS small GTPases 286526 Rho (Ras homology) subfamily of Ras-like small GTPases 286526 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 286535 Chromo Shadow Domain 286544 Immunoglobulin 286544 Immunoglobulin C-2 Type 286544 Immunoglobulin 286544 Immunoglobulin C-2 Type 286555 WD40 repeats 286653 A Receptor for Ubiquitination Targets 286722 Serine/Threonine protein kinases, catalytic domain 286729 EF-hand, calcium binding motif 286827 Ring finger 286888 Four-disulfide core domains 286888 Four-disulfide core domains 286895 membrane-attack complex / perforin 286901 membrane-attack complex / perforin 286901 membrane-attack complex / perforin 286903 GTPase-activator protein for Rho-like GTPases 286903 GTPase-activator protein for Rho-like GTPases 286908 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 286908 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 286908 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 286908 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 286911 Trypsin-like serine protease 286911 Trypsin-like serine protease 286916 Papain family cysteine protease 286916 Papain family cysteine protease 286918 Dynamin GTPase effector domain 286924 ARF-like small GTPases 286924 G protein alpha subunit 286926 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 286926 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 286927 Tyrosine kinase, catalytic domain 286927 Serine/Threonine protein kinases, catalytic domain 286928 Src homology 3 domains 286931 Protein kinase C conserved region 2 (CalB) 286934 Immunoglobulin 286940 Filamin-type immunoglobulin domains 286958 Defensin/corticostatin family 286960 Trypsin-like serine protease 286960 Trypsin-like serine protease 286966 Laminin G domain 286966 Laminin-type epidermal growth factor-like domai 286973 RNA recognition motif 286975 Src homology 3 domains 286975 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 286979 krueppel associated box 286987 Transferrin 286990 high mobility group 286993 Major prion protein 286993 Serine/Threonine protein kinases, catalytic domain 286993 Major prion protein 286995 Defensin/corticostatin family 286995 Defensin/corticostatin family 286996 krueppel associated box 286996 krueppel associated box 286997 Serine/Threonine protein kinases, catalytic domain 286997 Tyrosine kinase, catalytic domain 286997 Serine/Threonine protein kinases, catalytic domain 286998 Ubiquitin homologues 287015 Fibronectin type 3 domain 287046 14-3-3 homologues 287060 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 287068 bromo domain 287074 leucine rich region 287075 Thymosin beta actin-binding motif 287095 krueppel associated box 287102 Kringle domain 287102 present in yeast cell wall integrity and stress response component proteins 287102 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 287104 Trypsin-like serine protease 287106 Trypsin-like serine protease 287108 Trypsin-like serine protease 287108 Trypsin-like serine protease 287109 Broad-Complex, Tramtrack and Bric a brac 287110 domain in TBC and LysM domain containing proteins 287110 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 287114 deoxyribonuclease I 287120 WD40 repeats 287130 Laminin G domain 287130 Pentraxin / C-reactive protein / pentaxin family 287132 U1-like zinc finger 287136 Trypsin-like serine protease 287137 Trypsin-like serine protease 287138 Trypsin-like serine protease 287140 Trypsin-like serine protease 287141 Trypsin-like serine protease 287142 Trypsin-like serine protease 287143 Trypsin-like serine protease 287155 Tetratricopeptide repeats 287155 Modified RING finger domain 287156 Rho (Ras homology) subfamily of Ras-like small GTPases 287158 suppressors of cytokine signalling 287160 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 287165 Regulator of G protein signalling domain 287178 Ubiquitin homologues 287179 Serine/Threonine protein kinases, catalytic domain 287180 Serine/Threonine protein kinases, catalytic domain 287185 FORKHEAD 287195 prohibitin homologues 287206 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 287208 Tetratricopeptide repeats 287215 snRNP Sm proteins 287217 Immunoglobulin 287218 Immunoglobulin 287220 Immunoglobulin 287223 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 287224 Immunoglobulin 287224 Immunoglobulin V-Type 287228 GTPase-activator protein for Rho-like GTPases 287229 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 287230 Thymosin beta actin-binding motif 287251 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 287252 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 287266 krueppel associated box 287268 Tyrosine kinase, catalytic domain 287268 Serine/Threonine protein kinases, catalytic domain 287269 Tyrosine kinase, catalytic domain 287269 Serine/Threonine protein kinases, catalytic domain 287276 ARF-like small GTPases 287276 G protein alpha subunit 287276 Rab subfamily of small GTPases 287276 Sar1p-like members of the Ras-family of small GTPases 287280 Found in Skp1 protein family 287287 Interleukins 4 and 13 287293 high mobility group 287297 Guanine nucleotide exchange factor for Ras-like GTPases 287299 Immunoglobulin 287299 Immunoglobulin C-2 Type 287307 Cold shock protein domain 287352 Histone H3 287353 Tyrosine kinase, catalytic domain 287353 Serine/Threonine protein kinases, catalytic domain 287354 ATPases associated with a variety of cellular activities 287354 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 287357 found in Wnt-1 287358 Trypsin-like serine protease 287361 leucine rich region 287361 krueppel associated box 287362 Leucine rich repeat, ribonuclease inhibitor type 287366 Phospholipase D. Active site motifs. Phosphatidylcholine-hydrolyzing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of cert 287367 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 287375 Gelsolin homology domain 287382 Fibrinogen-related domains (FReDs) 287384 Src homology 2 domains 287384 Src homology 3 domains 287398 Tyrosine kinase, catalytic domain 287398 Serine/Threonine protein kinases, catalytic domain 287409 Src homology 3 domains 287418 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 287425 Lipoxygenase homology 2 (beta barrel) domain 287429 snRNP Sm proteins 287436 DEAD-like helicases superfamily 287436 helicase superfamily c-terminal domain 287437 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 287447 catalytic domain of ctd-like phosphatases 287466 present in yeast cell wall integrity and stress response component proteins 287469 FORKHEAD 287470 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 287472 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 287473 Tyrosine kinase, catalytic domain 287473 Serine/Threonine protein kinases, catalytic domain 287478 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. Function unknown, but likely to be associated with the glycosylation machinery 287521 helix loop helix domain 287522 G protein gamma subunit-like motifs 287525 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 287526 SERine Proteinase INhibitors 287526 SERine Proteinase INhibitors 287527 SERine Proteinase INhibitors 287528 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 287530 JAB/MPN domain 287533 Inositol polyphosphate phosphatase, catalytic domain homologues 287537 GTPase-activator protein for Rho-like GTPases 287545 Toll - interleukin 1 - resistance 287547 Ubiquitin homologues 287557 Alpha-lactalbumin / lysozyme C 287559 prohibitin homologues 287561 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 287562 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 287563 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 287567 breast cancer carboxy-terminal domain 287570 Calponin homology domain 287574 Four-disulfide core domains 287582 Homeodomain 287583 Homeodomain 287607 Protein present in Fab1, YOTB, Vac1, and EEA1 287609 Src homology 3 domains 287609 Fibronectin type 3 domain 287617 RNA recognition motif 287618 Ubiquitin homologues 287619 Ubiquitin homologues 287620 Ubiquitin homologues 287622 Domain present in VPS-27, Hrs and STAM 287624 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 287631 Immunoglobulin 287631 Immunoglobulin C-2 Type 287631 Kazal type serine protease inhibitors 287631 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 287636 Fibrillar collagens C-terminal domain 287636 von Willebrand factor (vWF) type C domain 287637 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 287638 Homeodomain 287643 meprin and TRAF homology 287647 Homeodomain 287648 Src homology 3 domains 287648 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 287650 Domain first found in the mice T locus (Brachyury) protein 287658 Dual specificity phosphatase, catalytic domain 287659 suppressors of cytokine signalling 287661 CDGSH-type zinc finger. Function unknown 287670 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 287691 Rab subfamily of small GTPases 287691 Ras subfamily of RAS small GTPases 287691 Rho (Ras homology) subfamily of Ras-like small GTPases 287691 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 287706 Broad-Complex, Tramtrack and Bric a brac 287707 Rab subfamily of small GTPases 287707 Ras subfamily of RAS small GTPases 287707 Rho (Ras homology) subfamily of Ras-like small GTPases 287707 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 287708 ARF-like small GTPases 287708 Rab subfamily of small GTPases 287708 Ras subfamily of RAS small GTPases 287708 Rho (Ras homology) subfamily of Ras-like small GTPases 287708 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 287709 ARF-like small GTPases 287709 Rab subfamily of small GTPases 287709 Ras subfamily of RAS small GTPases 287709 Rho (Ras homology) subfamily of Ras-like small GTPases 287709 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 287715 Serine/Threonine protein kinases, catalytic domain 287723 BCL (B-Cell lymphoma) 287726 RNA recognition motif 287729 Protein tyrosine phosphatase, catalytic domain 287729 Dual specificity phosphatase, catalytic domain 287729 Protein tyrosine phosphatase, catalytic domain motif 287730 Pancreatic hormones / neuropeptide F / peptide YY family 287745 Phospholipase C, catalytic domain (part) 287745 Protein kinase C conserved region 2 (CalB) 287748 Domain with 2 conserved Trp (W) residues 287748 GTPase-activator protein for Rho-like GTPases 287751 Alpha-lactalbumin / lysozyme C 287762 Serine/Threonine protein kinases, catalytic domain 287762 domain in protein kinases, N-glycanases and other nuclear proteins 287763 beta-propeller repeat 287763 Tyrosine kinase, catalytic domain 287763 Serine/Threonine protein kinases, catalytic domain 287765 DEAD-like helicases superfamily 287765 helicase superfamily c-terminal domain 287768 Tudor domain 287772 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 287774 Domain abundant in complement control proteins 287792 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 287806 Immunoglobulin 287806 Immunoglobulin V-Type 287808 Immunoglobulin V-Type 287809 Immunoglobulin 287809 Immunoglobulin V-Type 287809 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 287810 Immunoglobulin 287810 Immunoglobulin V-Type 287812 Immunoglobulin V-Type 287813 Immunoglobulin V-Type 287815 Immunoglobulin 287815 Immunoglobulin V-Type 287818 Immunoglobulin 287819 ankyrin repeats 287819 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 287824 Ring finger 287824 Domain in SPla and the RYanodine Receptor. 287825 Domain in SPla and the RYanodine Receptor. 287833 Src homology 3 domains 287838 Serine/Threonine protein kinases, catalytic domain 287844 Ribosomal protein L11/L12 287848 Myosin. Large ATPases. ATPase 287849 Myosin. Large ATPases. ATPase 287853 Myosin. Large ATPases. ATPase 287859 Myosin. Large ATPases. ATPase 287863 Myosin. Large ATPases. ATPase 287881 ankyrin repeats 287889 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 287895 14-3-3 homologues 287908 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 287909 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 287910 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 287911 Ubiquitin homologues 287912 Ubiquitin homologues 287913 Ubiquitin homologues 287917 RNA recognition motif 287919 Thymosin beta actin-binding motif 287931 Serine/threonine phosphatases, family 2C, catalytic domain 287931 Sigma factor PP2C-like phosphatases 287931 Serine/threonine phosphatases, family 2C, catalytic domain 287934 Modified RING finger domain 287939 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 287940 Broad-Complex, Tramtrack and Bric a brac 287941 Src homology 2 domains 287942 Src homology 3 domains 287943 Broad-Complex, Tramtrack and Bric a brac 287944 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 287956 Domain with 2 conserved Trp (W) residues 287960 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 287964 Immunoglobulin 287964 Immunoglobulin C-Type 287964 Immunoglobulin V-Type 287965 Immunoglobulin C-Type 287966 Immunoglobulin 287966 Immunoglobulin V-Type 287967 Immunoglobulin 287967 Immunoglobulin V-Type 287974 Kelch domain 287974 Zinc finger domain 287975 Broad-Complex, Tramtrack and Bric a brac 287986 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 287988 RNA polymerase subunit 8 287989 Fibronectin type 3 domain 287989 Tyrosine kinase, catalytic domain 287989 Ephrin receptor ligand binding domain 287989 Serine/Threonine protein kinases, catalytic domain 287989 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 287993 Ubiquitin homologues 287994 Ubiquitin homologues 287995 RNA recognition motif 287997 Beta/gamma crystallins 287999 Cystatin-like domain 288000 Histone H3 288001 Cystatin-like domain 288002 Histone H3 288003 ATPases associated with a variety of cellular activities 288007 Trypsin-like serine protease 288007 Domain abundant in complement control proteins 288007 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 288013 U1-like zinc finger 288016 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 288018 RNA recognition motif 288018 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 288040 RNA recognition motif 288042 Domain in SPla and the RYanodine Receptor. 288052 domain present in cyclins, TFIIB and Retinoblastoma 288057 Immunoglobulin 288057 Immunoglobulin C-2 Type 288060 semaphorin domain 288063 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 288064 Armadillo/beta-catenin-like repeats 288067 Cystatin-like domain 288068 Cystatin-like domain 288070 Cystatin-like domain 288071 Cystatin-like domain 288072 Cystatin-like domain 288074 Cystatin-like domain 288075 Cystatin-like domain 288077 Src homology 3 domains 288079 DNA polymerase A domain 288079 helicase superfamily c-terminal domain 288082 Rab subfamily of small GTPases 288084 Transcription initiation factor IIE 288085 Rab subfamily of small GTPases 288090 Immunoglobulin 288091 Putative lipopolysaccharide-modifying enzyme 288103 Tyrosine kinase, catalytic domain 288103 Serine/Threonine protein kinases, catalytic domain 288112 Immunoglobulin 288112 Immunoglobulin C-2 Type 288114 RNA recognition motif 288117 Cyclic nucleotide-monophosphate binding domain 288118 Trypsin-like serine protease 288118 Low-density lipoprotein receptor domain class A 288129 helicase superfamily c-terminal domain 288136 DnaJ molecular chaperone homology domain 288137 Myosin. Large ATPases. ATPase 288151 Homeodomain 288152 Homeodomain 288153 Homeodomain 288154 Homeodomain 288155 Homeodomain 288159 high mobility group 288160 Integrin beta subunits (N-terminal portion of extracellular region) 288163 RNA polymerase subunit CX 288178 Tyrosine kinase, catalytic domain 288178 Serine/Threonine protein kinases, catalytic domain 288179 krueppel associated box 288204 Ricin-type beta-trefoil 288208 Fibronectin type 3 domain 288209 Fibronectin type 3 domain 288217 eukaryotic translation initiation factor 1A 288218 eukaryotic translation initiation factor 1A 288226 krueppel associated box 288231 Immunoglobulin 288231 Immunoglobulin C-2 Type 288241 snRNP Sm proteins 288243 Histidine kinase-like ATPases 288276 RNA recognition motif 288280 Immunoglobulin 288280 Immunoglobulin C-2 Type 288280 Fibronectin type 3 domain 288281 K homology RNA-binding domain 288282 K homology RNA-binding domain 288287 Low-density lipoprotein receptor domain class A 288287 Domain found in sea urchin sperm protein, enterokinase, agrin 288287 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 288287 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 288288 Low-density lipoprotein receptor domain class A 288288 Domain found in sea urchin sperm protein, enterokinase, agrin 288288 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 288288 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 288289 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288290 Trypsin-like serine protease 288291 Trypsin-like serine protease 288301 Dual specificity phosphatase, catalytic domain 288308 Ring finger 288310 RNA recognition motif 288321 RNA recognition motif 288323 high mobility group 288324 Immunoglobulin 288331 Putative lipopolysaccharide-modifying enzyme 288333 Alpha-amylase domain 288346 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 288356 Homeodomain 288358 Tyrosine kinase, catalytic domain 288358 Serine/Threonine protein kinases, catalytic domain 288359 von Willebrand factor (vWF) type C domain 288362 Myosin. Large ATPases. ATPase 288375 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288376 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288377 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288378 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288379 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288381 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288383 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288384 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288385 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288386 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288387 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288388 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 288391 Zona pellucida (ZP) domain 288398 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 288404 Chromatin organization modifier domain 288405 Chromatin organization modifier domain 288406 Chromatin organization modifier domain 288407 Chromatin organization modifier domain 288408 Chromatin organization modifier domain 288409 Chromatin organization modifier domain 288410 Chromatin organization modifier domain 288412 Chromatin organization modifier domain 288413 Chromatin organization modifier domain 288419 Chromatin organization modifier domain 288421 Ubiquitin homologues 288422 Ubiquitin homologues 288432 Chromatin organization modifier domain 288433 Chromatin organization modifier domain 288434 Chromatin organization modifier domain 288435 Chromatin organization modifier domain 288436 Chromatin organization modifier domain 288437 Chromatin organization modifier domain 288438 Chromatin organization modifier domain 288439 Chromatin organization modifier domain 288457 Homeodomain 288469 Armadillo/beta-catenin-like repeats 288470 Domain Homologous to E6-AP Carboxyl Terminus with 288471 Phosphoinositide 3-kinase, catalytic domain 288472 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 288475 LamG-like jellyroll fold domain 288475 Pentraxin / C-reactive protein / pentaxin family 288483 Rab subfamily of small GTPases 288483 Ras subfamily of RAS small GTPases 288483 Rho (Ras homology) subfamily of Ras-like small GTPases 288483 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 288486 krueppel associated box 288489 krueppel associated box 288491 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 288492 Immunoglobulin 288492 Immunoglobulin C-2 Type 288493 Fibronectin type 3 domain 288496 Forkhead associated domain 288504 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 288512 Leucine rich repeat C-terminal domain 288515 Calponin homology domain 288515 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 288515 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 288516 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 288529 Connexin homologues 288531 krueppel associated box 288532 minichromosome maintenance proteins 288550 Rab subfamily of small GTPases 288550 Ras subfamily of RAS small GTPases 288556 Calponin homology domain 288558 Calponin homology domain 288563 Actin 288567 Rab subfamily of small GTPases 288567 Ras subfamily of RAS small GTPases 288567 Rho (Ras homology) subfamily of Ras-like small GTPases 288567 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 288569 domain with conserved PWWP motif 288583 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 288583 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 288585 Rab subfamily of small GTPases 288585 Sar1p-like members of the Ras-family of small GTPases 288585 Rho (Ras homology) subfamily of Ras-like small GTPases 288586 EF-hand, calcium binding motif 288589 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 288593 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 288596 Ring finger 288596 B-Box C-terminal domain 288596 associated with SPRY domains 288596 Domain in SPla and the RYanodine Receptor. 288596 associated with SPRY domains 288598 bromo domain 288598 PHD zinc finger 288599 RNA recognition motif 288611 Ricin-type beta-trefoil 288613 EF-hand, calcium binding motif 288624 krueppel associated box 288625 krueppel associated box 288653 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 288660 I/LWEQ domain 288660 Epsin N-terminal homology (ENTH) domain 288664 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 288665 Homeodomain 288674 Serine/Threonine protein kinases, catalytic domain 288675 ADAM Cysteine-Rich Domain 288675 Homologues of snake disintegrins 288682 GTPase-activator protein for Ras-like GTPases 288682 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 288692 WD40 repeats 288692 suppressors of cytokine signalling 288698 Serine/Threonine protein kinases, catalytic domain 288700 ARF-like small GTPases 288700 Rab subfamily of small GTPases 288700 Ras subfamily of RAS small GTPases 288700 Rho (Ras homology) subfamily of Ras-like small GTPases 288700 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 288701 RNA recognition motif 288723 Tetratricopeptide repeats 288729 DEAD-like helicases superfamily 288736 FORKHEAD 288743 domain involved in Ras-like GTPase signaling 288743 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 288772 Domain in SPla and the RYanodine Receptor. 288774 Src homology 2 domains 288780 ARF-like small GTPases 288780 Rab subfamily of small GTPases 288780 Ras subfamily of RAS small GTPases 288780 Rho (Ras homology) subfamily of Ras-like small GTPases 288780 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 288786 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 288819 RNA recognition motif 288821 helix loop helix domain 288914 zinc finger 288915 Domain A in dwarfin family proteins 288929 RNA recognition motif 288931 membrane-attack complex / perforin 288937 SERine Proteinase INhibitors 288941 SERine Proteinase INhibitors 288959 ankyrin repeats 288963 krueppel associated box 288965 krueppel associated box 288966 krueppel associated box 288967 krueppel associated box 288969 krueppel associated box 288974 Coagulation factor 5/8 C-terminal domain, discoidin domain 288979 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 288982 Scavenger receptor Cys-rich 289001 Tyrosine kinase, catalytic domain 289001 Serine/Threonine protein kinases, catalytic domain 289007 Thrombospondin type 1 repeats 289010 Domain abundant in complement control proteins 289010 Domain abundant in complement control proteins 289014 Serine/Threonine protein kinases, catalytic domain 289014 Tyrosine kinase, catalytic domain 289014 Serine/Threonine protein kinases, catalytic domain 289016 Fes/CIP4 homology domain 289020 Immunoglobulin 289020 Immunoglobulin C-2 Type 289020 Fibronectin type 3 domain 289021 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 289027 snRNP Sm proteins 289032 Chitin-binding domain type 2 289040 PHD zinc finger 289041 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289043 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289047 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 289048 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 289051 Calcium-binding EGF-like domain 289052 Broad-Complex, Tramtrack and Bric a brac 289055 Domain abundant in complement control proteins 289056 Domain abundant in complement control proteins 289057 Domain abundant in complement control proteins 289058 Domain abundant in complement control proteins 289070 RNA recognition motif 289074 Regulator of G protein signalling domain 289075 Regulator of G protein signalling domain 289076 Regulator of G protein signalling domain 289080 Ras association (RalGDS/AF-6) domain 289089 Kelch domain 289090 Broad-Complex, Tramtrack and Bric a brac 289120 Immunoglobulin C-Type 289125 ankyrin repeats 289129 Tudor domain 289145 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 289148 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 289152 ankyrin repeats 289158 Homeodomain 289187 Dual specificity phosphatase, catalytic domain 289188 Immunoglobulin 289188 Immunoglobulin V-Type 289188 Immunoglobulin C-2 Type 289189 Cold shock protein domain 289190 high mobility group 289198 Src homology 3 domains 289200 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 289201 Homeodomain 289201 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 289208 Dual specificity phosphatase, catalytic domain 289211 Immunoglobulin 289211 Immunoglobulin 289224 Immunoglobulin 289224 Immunoglobulin C-2 Type 289236 Immunoglobulin 289236 Immunoglobulin V-Type 289236 Immunoglobulin C-2 Type 289243 Pentraxin / C-reactive protein / pentaxin family 289244 Immunoglobulin 289257 Spectrin repeats 289264 C-terminal cystine knot-like domain (CTCK) 289286 Low-density lipoprotein-receptor YWTD domain 289288 Tyrosine kinase, catalytic domain 289288 Serine/Threonine protein kinases, catalytic domain 289291 Tyrosine kinase, catalytic domain 289291 Serine/Threonine protein kinases, catalytic domain 289297 Low molecular weight phosphatase family 289311 Homeodomain 289314 Histone H3 289316 Transforming growth factor-beta (TGF-beta) family 289318 Transforming growth factor-beta (TGF-beta) family 289323 ATPases associated with a variety of cellular activities 289325 WD40 repeats 289335 Domain abundant in complement control proteins 289337 Toll - interleukin 1 - resistance 289337 Leucine rich repeat C-terminal domain 289341 Laminin G domain 289364 c4 zinc finger in nuclear hormone receptors 289365 c4 zinc finger in nuclear hormone receptors 289367 Ligand binding domain of hormone receptors 289368 LamG-like jellyroll fold domain 289369 Fibronectin type 3 domain 289370 Fibronectin type 3 domain 289392 semaphorin domain 289394 domain found in Plexins, Semaphorins and Integrins 289395 Domain abundant in complement control proteins 289396 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289397 WD40 repeats 289405 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289417 Domain abundant in complement control proteins 289419 RIO-like kinase 289419 Tyrosine kinase, catalytic domain 289419 Serine/Threonine protein kinases, catalytic domain 289432 Armadillo/beta-catenin-like repeats 289436 Armadillo/beta-catenin-like repeats 289438 Broad-Complex, Tramtrack and Bric a brac 289439 Phosphate acyltransferases 289450 krueppel associated box 289451 krueppel associated box 289452 krueppel associated box 289457 Kelch domain 289460 Dual specificity phosphatase, catalytic domain 289460 Protein tyrosine phosphatase, catalytic domain 289460 Protein tyrosine phosphatase, catalytic domain motif 289462 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 289485 Tyrosine kinase, catalytic domain 289485 Serine/Threonine protein kinases, catalytic domain 289487 Furin-like repeats 289488 Furin-like repeats 289501 ankyrin repeats 289503 Cold shock protein domain 289505 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 289534 Kelch domain 289534 Broad-Complex, Tramtrack and Bric a brac 289539 RNA recognition motif 289544 Trypsin-like serine protease 289546 Trypsin-like serine protease 289547 Trypsin-like serine protease 289547 Domain found in sea urchin sperm protein, enterokinase, agrin 289549 Serine/Threonine protein kinases, catalytic domain 289551 Fibronectin type 3 domain 289560 Kazal type serine protease inhibitors 289565 ARF-like small GTPases 289565 Ras subfamily of RAS small GTPases 289565 Sar1p-like members of the Ras-family of small GTPases 289575 Immunoglobulin 289575 Immunoglobulin C-2 Type 289575 Tyrosine kinase, catalytic domain 289575 Serine/Threonine protein kinases, catalytic domain 289581 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 289596 Trypsin-like serine protease 289596 Low-density lipoprotein receptor domain class A 289596 Frizzled 289596 Low-density lipoprotein receptor domain class A 289596 Frizzled 289596 Scavenger receptor Cys-rich 289596 Low-density lipoprotein receptor domain class A 289600 Trypsin-like serine protease 289610 Broad-Complex, Tramtrack and Bric a brac 289623 Ubiquitin associated domain 289623 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289628 breast cancer carboxy-terminal domain 289630 RNA recognition motif 289641 WD40 repeats 289643 RNA recognition motif 289657 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 289658 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 289663 Ubiquitin homologues 289686 Galectin 289693 helicase superfamily c-terminal domain 289717 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 289720 Saposin/surfactant protein-B A-type DOMAIN 289721 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 289722 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289733 Phospholipase A2 289734 Calponin homology domain 289738 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 289741 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 289742 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 289743 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 289747 leukemia inhibitory factor 289751 RNA recognition motif 289754 basic region leucin zipper 289756 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289757 DNA polymerase X family 289770 RNA recognition motif 289777 ATPases associated with a variety of cellular activities 289784 Histone 2A 289793 Rab subfamily of small GTPases 289794 Protein tyrosine phosphatase, catalytic domain 289794 Protein tyrosine phosphatase, catalytic domain motif 289797 ATPases associated with a variety of cellular activities 289806 Cold shock protein domain 289809 K homology RNA-binding domain 289820 Actin 289858 Ribosomal protein S1-like RNA-binding domain 289867 WD40 repeats 289910 Dual specificity phosphatase, catalytic domain 289915 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 289924 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 289926 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 289927 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 289935 domain present in PNGases and other hypothetical proteins 289936 high mobility group 289939 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 289942 Histone 2A 289944 Ubiquitin homologues 289951 Filamin-type immunoglobulin domains 289968 Ricin-type beta-trefoil 289971 Ricin-type beta-trefoil 289973 Ricin-type beta-trefoil 289976 Ricin-type beta-trefoil 289985 Ricin-type beta-trefoil 289989 Histone H3 289990 ATPases associated with a variety of cellular activities 289992 Band 4.1 homologues 289993 Dual specificity phosphatase, catalytic domain 289993 Protein tyrosine phosphatase, catalytic domain 289993 Protein tyrosine phosphatase, catalytic domain motif 290012 Toll - interleukin 1 - resistance 290033 Histone H3 290035 Pancreatic ribonuclease 290036 Pancreatic ribonuclease 290037 Pancreatic ribonuclease 290039 Pancreatic ribonuclease 290040 Pancreatic ribonuclease 290046 RNA recognition motif 290053 Immunoglobulin 290053 Immunoglobulin V-Type 290058 Immunoglobulin 290058 Immunoglobulin V-Type 290059 Immunoglobulin 290059 Immunoglobulin V-Type 290061 Immunoglobulin 290061 Immunoglobulin V-Type 290062 Immunoglobulin 290062 Immunoglobulin V-Type 290064 Immunoglobulin 290064 Immunoglobulin V-Type 290066 Immunoglobulin 290066 Immunoglobulin V-Type 290067 Immunoglobulin 290067 Immunoglobulin V-Type 290068 Immunoglobulin 290069 Immunoglobulin 290069 Immunoglobulin V-Type 290070 Immunoglobulin 290070 Immunoglobulin V-Type 290071 Immunoglobulin 290071 Immunoglobulin V-Type 290072 Immunoglobulin 290072 Immunoglobulin V-Type 290073 Immunoglobulin 290073 Immunoglobulin V-Type 290074 Immunoglobulin 290074 Immunoglobulin V-Type 290075 Immunoglobulin 290075 Immunoglobulin V-Type 290076 Immunoglobulin 290076 Immunoglobulin V-Type 290077 Immunoglobulin 290077 Immunoglobulin V-Type 290078 Immunoglobulin 290078 Immunoglobulin V-Type 290079 Immunoglobulin 290079 Immunoglobulin V-Type 290080 Immunoglobulin 290080 Immunoglobulin V-Type 290081 Immunoglobulin 290081 Immunoglobulin V-Type 290083 Immunoglobulin 290083 Immunoglobulin V-Type 290084 Immunoglobulin 290084 Immunoglobulin V-Type 290085 Immunoglobulin 290085 Immunoglobulin V-Type 290086 Immunoglobulin 290086 Immunoglobulin V-Type 290087 Immunoglobulin 290087 Immunoglobulin V-Type 290088 Immunoglobulin 290088 Immunoglobulin V-Type 290089 Immunoglobulin 290089 Immunoglobulin V-Type 290090 Immunoglobulin 290091 Immunoglobulin 290091 Immunoglobulin V-Type 290091 Immunoglobulin C-2 Type 290092 Immunoglobulin 290092 Immunoglobulin V-Type 290093 Immunoglobulin 290093 Immunoglobulin V-Type 290094 Immunoglobulin 290094 Immunoglobulin V-Type 290095 Immunoglobulin 290095 Immunoglobulin V-Type 290096 Immunoglobulin 290097 Immunoglobulin 290097 Immunoglobulin V-Type 290098 Immunoglobulin 290098 Immunoglobulin V-Type 290099 Immunoglobulin 290099 Immunoglobulin V-Type 290100 Immunoglobulin 290100 Immunoglobulin V-Type 290101 Immunoglobulin 290101 Immunoglobulin V-Type 290103 Immunoglobulin 290103 Immunoglobulin V-Type 290104 Immunoglobulin 290104 Immunoglobulin V-Type 290105 Immunoglobulin 290105 Immunoglobulin V-Type 290106 Immunoglobulin 290106 Immunoglobulin V-Type 290107 Immunoglobulin 290107 Immunoglobulin V-Type 290108 Immunoglobulin 290108 Immunoglobulin V-Type 290110 Immunoglobulin 290110 Immunoglobulin V-Type 290111 Immunoglobulin 290111 Immunoglobulin V-Type 290112 Immunoglobulin 290112 Immunoglobulin V-Type 290113 Immunoglobulin 290113 Immunoglobulin V-Type 290114 Immunoglobulin 290114 Immunoglobulin V-Type 290115 Immunoglobulin 290115 Immunoglobulin V-Type 290116 Immunoglobulin 290116 Immunoglobulin V-Type 290117 Immunoglobulin 290117 Immunoglobulin V-Type 290118 Immunoglobulin 290118 Immunoglobulin V-Type 290119 Immunoglobulin 290119 Immunoglobulin V-Type 290120 Immunoglobulin 290120 Immunoglobulin V-Type 290121 Immunoglobulin 290121 Immunoglobulin V-Type 290122 Immunoglobulin 290122 Immunoglobulin V-Type 290123 Immunoglobulin 290123 Immunoglobulin V-Type 290124 Immunoglobulin 290124 Immunoglobulin V-Type 290125 Immunoglobulin 290125 Immunoglobulin V-Type 290126 Immunoglobulin 290126 Immunoglobulin V-Type 290127 Immunoglobulin 290127 Immunoglobulin V-Type 290128 Immunoglobulin 290128 Immunoglobulin V-Type 290129 Immunoglobulin 290129 Immunoglobulin V-Type 290130 Immunoglobulin 290130 Immunoglobulin V-Type 290131 Immunoglobulin 290131 Immunoglobulin V-Type 290132 Immunoglobulin 290132 Immunoglobulin V-Type 290133 Immunoglobulin 290133 Immunoglobulin V-Type 290134 Immunoglobulin 290134 Immunoglobulin V-Type 290135 Immunoglobulin 290135 Immunoglobulin V-Type 290136 Immunoglobulin 290136 Immunoglobulin V-Type 290137 Immunoglobulin 290137 Immunoglobulin V-Type 290138 Immunoglobulin 290138 Immunoglobulin V-Type 290139 Immunoglobulin 290139 Immunoglobulin V-Type 290140 Immunoglobulin 290140 Immunoglobulin V-Type 290141 Immunoglobulin 290141 Immunoglobulin V-Type 290142 Immunoglobulin 290142 Immunoglobulin V-Type 290143 Immunoglobulin 290143 Immunoglobulin V-Type 290144 Immunoglobulin 290144 Immunoglobulin V-Type 290145 Immunoglobulin 290145 Immunoglobulin V-Type 290147 Immunoglobulin 290147 Immunoglobulin V-Type 290148 Immunoglobulin 290148 Immunoglobulin V-Type 290149 Immunoglobulin 290149 Immunoglobulin V-Type 290149 Immunoglobulin C-2 Type 290150 Immunoglobulin 290150 Immunoglobulin V-Type 290151 Immunoglobulin 290151 Immunoglobulin V-Type 290152 Immunoglobulin 290152 Immunoglobulin V-Type 290154 Immunoglobulin 290154 Immunoglobulin V-Type 290155 Immunoglobulin 290155 Immunoglobulin V-Type 290156 Immunoglobulin 290156 Immunoglobulin V-Type 290157 Immunoglobulin 290157 Immunoglobulin V-Type 290158 Immunoglobulin 290158 Immunoglobulin V-Type 290159 Immunoglobulin 290159 Immunoglobulin V-Type 290160 Immunoglobulin 290160 Immunoglobulin V-Type 290161 Immunoglobulin 290161 Immunoglobulin V-Type 290162 Immunoglobulin 290162 Immunoglobulin V-Type 290163 Immunoglobulin 290163 Immunoglobulin V-Type 290164 Immunoglobulin 290164 Immunoglobulin V-Type 290165 Immunoglobulin 290165 Immunoglobulin V-Type 290166 Immunoglobulin 290166 Immunoglobulin V-Type 290167 Immunoglobulin 290167 Immunoglobulin V-Type 290168 Immunoglobulin 290168 Immunoglobulin V-Type 290169 Immunoglobulin 290169 Immunoglobulin V-Type 290170 Immunoglobulin 290170 Immunoglobulin V-Type 290172 Immunoglobulin 290172 Immunoglobulin V-Type 290173 Immunoglobulin 290173 Immunoglobulin V-Type 290174 Immunoglobulin 290174 Immunoglobulin V-Type 290175 Immunoglobulin 290175 Immunoglobulin V-Type 290176 Immunoglobulin 290176 Immunoglobulin V-Type 290178 Immunoglobulin 290178 Immunoglobulin V-Type 290179 Immunoglobulin 290179 Immunoglobulin V-Type 290181 Immunoglobulin 290181 Immunoglobulin V-Type 290182 Immunoglobulin 290182 Immunoglobulin V-Type 290183 Immunoglobulin 290183 Immunoglobulin V-Type 290185 Immunoglobulin 290185 Immunoglobulin V-Type 290186 Immunoglobulin 290186 Immunoglobulin V-Type 290188 Immunoglobulin 290188 Immunoglobulin V-Type 290189 Immunoglobulin 290189 Immunoglobulin V-Type 290190 Immunoglobulin 290190 Immunoglobulin V-Type 290191 Immunoglobulin 290191 Immunoglobulin V-Type 290192 Immunoglobulin 290192 Immunoglobulin V-Type 290194 Immunoglobulin 290194 Immunoglobulin V-Type 290195 Immunoglobulin 290195 Immunoglobulin V-Type 290196 Immunoglobulin 290196 Immunoglobulin V-Type 290197 Immunoglobulin 290197 Immunoglobulin V-Type 290198 Immunoglobulin C-Type 290199 Immunoglobulin 290199 Immunoglobulin V-Type 290199 Immunoglobulin C-2 Type 290207 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 290211 RNA recognition motif 290229 Tyrosine kinase, catalytic domain 290229 Serine/Threonine protein kinases, catalytic domain 290240 Trypsin-like serine protease 290241 Trypsin-like serine protease 290242 Trypsin-like serine protease 290243 Trypsin-like serine protease 290244 Trypsin-like serine protease 290245 Trypsin-like serine protease 290246 Trypsin-like serine protease 290247 Trypsin-like serine protease 290248 Trypsin-like serine protease 290249 Trypsin-like serine protease 290250 Trypsin-like serine protease 290251 Trypsin-like serine protease 290252 Trypsin-like serine protease 290253 Trypsin-like serine protease 290255 Trypsin-like serine protease 290256 Trypsin-like serine protease 290257 Trypsin-like serine protease 290259 Trypsin-like serine protease 290260 Trypsin-like serine protease 290261 Trypsin-like serine protease 290262 Trypsin-like serine protease 290263 Trypsin-like serine protease 290264 Trypsin-like serine protease 290265 Trypsin-like serine protease 290266 Trypsin-like serine protease 290267 Trypsin-like serine protease 290295 erythroblast transformation specific domain 290299 Src homology 3 domains 290303 Domain in SPla and the RYanodine Receptor. 290311 SERine Proteinase INhibitors 290317 high mobility group 290320 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 290323 Annexin repeats 290326 Tyrosine kinase, catalytic domain 290326 Serine/Threonine protein kinases, catalytic domain 290338 Homologues of snake disintegrins 290340 Chromatin organization modifier domain 290341 WD40 repeats 290342 WD40 repeats 290344 ADAM Cysteine-Rich Domain 290344 Homologues of snake disintegrins 290344 ADAM Cysteine-Rich Domain 290344 Homologues of snake disintegrins 290345 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 290352 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 290354 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 290354 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 290355 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 290361 Phosphotyrosine-binding domain (IRS1-like) 290361 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 290363 Broad-Complex, Tramtrack and Bric a brac 290370 DnaJ molecular chaperone homology domain 290377 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 290378 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 290379 Serine/Threonine protein kinases, catalytic domain 290383 von Willebrand factor (vWF) type A domain 290392 Guanine nucleotide exchange factor for Ras-like GTPases 290395 Formin Homology 2 Domain 290396 Formin Homology 2 Domain 290397 Formin Homology 2 Domain 290400 Calponin homology domain 290402 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 290409 Olfactomedin-like domains 290418 Serine/Threonine protein kinases, catalytic domain 290426 Kelch domain 290426 Broad-Complex, Tramtrack and Bric a brac 290428 snRNP Sm proteins 290429 Found in Pit-Oct-Unc transcription factors 290430 U1-like zinc finger 290430 RNA recognition motif 290434 Ubiquitin homologues 290441 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 290442 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 290445 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 290457 RNA recognition motif 290458 Ring finger 290467 Leucine rich repeat C-terminal domain 290470 K homology RNA-binding domain 290501 Tetratricopeptide repeats 290507 Ubiquitin homologues 290511 Immunoglobulin 290511 Immunoglobulin V-Type 290512 Immunoglobulin 290512 Immunoglobulin V-Type 290513 Immunoglobulin 290513 Immunoglobulin V-Type 290514 Immunoglobulin 290514 Immunoglobulin V-Type 290515 Immunoglobulin 290515 Immunoglobulin V-Type 290516 Immunoglobulin 290516 Immunoglobulin V-Type 290517 Immunoglobulin 290522 PAS domain 290528 Annexin repeats 290530 Homeodomain 290536 suppressors of cytokine signalling 290537 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 290538 Homeodomain 290541 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 290544 Leucine rich repeat C-terminal domain 290544 Leucine rich repeat N-terminal domain 290547 RNA recognition motif 290550 Actin 290557 high mobility group 290559 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts 290562 semaphorin domain 290562 domain found in Plexins, Semaphorins and Integrins 290570 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 290574 krueppel associated box 290575 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 290581 Guanine nucleotide exchange factor for Ras-like GTPases 290582 Guanine nucleotide exchange factor for Ras-like GTPases 290583 Guanine nucleotide exchange factor for Ras-like GTPases 290587 Guanine nucleotide exchange factor for Ras-like GTPases 290589 Guanine nucleotide exchange factor for Ras-like GTPases 290590 Guanine nucleotide exchange factor for Ras-like GTPases 290594 Immunoglobulin 290594 Immunoglobulin C-2 Type 290594 Leucine rich repeat C-terminal domain 290611 Src homology 2 domains 290613 Myosin. Large ATPases. ATPase 290613 Ras association (RalGDS/AF-6) domain 290617 Eps15 homology domain 290625 krueppel associated box 290646 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 290647 snRNP Sm proteins 290652 Tetratricopeptide repeats 290656 Broad-Complex, Tramtrack and Bric a brac 290657 Kelch domain 290657 Broad-Complex, Tramtrack and Bric a brac 290658 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 290660 DEAD-like helicases superfamily 290661 glycine rich nucleic binding domain 290666 glycine rich nucleic binding domain 290670 Tyrosine kinase, catalytic domain 290670 Serine/Threonine protein kinases, catalytic domain 290674 ankyrin repeats 290677 Found in Skp1 protein family 290680 Sec7 domain 290692 Kelch domain 290694 Zinc-dependent metalloprotease 290694 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 290695 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 290702 Immunoglobulin 290704 Immunoglobulin 290704 Immunoglobulin C-2 Type 290708 Calponin homology domain 290715 Ricin-type beta-trefoil 290726 ADAM Cysteine-Rich Domain 290726 Homologues of snake disintegrins 290744 PHD zinc finger 290745 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 290753 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 290757 APPLE domain 290757 Trypsin-like serine protease 290763 ADAM Cysteine-Rich Domain 290763 Homologues of snake disintegrins 290766 associated with SPRY domains 290766 Domain in SPla and the RYanodine Receptor. 290767 Ring finger 290767 associated with SPRY domains 290767 Domain in SPla and the RYanodine Receptor. 290768 Ubiquitin homologues 290771 Immunoglobulin 290771 Immunoglobulin C-2 Type 290772 Ubiquitin homologues 290773 ADAM Cysteine-Rich Domain 290773 Homologues of snake disintegrins 290774 ADAM Cysteine-Rich Domain 290774 Homologues of snake disintegrins 290778 WD40 repeats 290781 Domain A in dwarfin family proteins 290787 snRNP Sm proteins 290792 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 290794 ankyrin repeats 290805 3'-5' exonuclease 290805 DEAD-like helicases superfamily 290805 helicase superfamily c-terminal domain 290812 Ring finger 290818 Tyrosine kinase, catalytic domain 290818 Serine/Threonine protein kinases, catalytic domain 290819 Tyrosine kinase, catalytic domain 290819 Serine/Threonine protein kinases, catalytic domain 290829 Domain in SPla and the RYanodine Receptor. 290834 ADAM Cysteine-Rich Domain 290834 Zinc-dependent metalloprotease 290834 Homologues of snake disintegrins 290838 U1-like zinc finger 290840 RNA recognition motif 290843 Phosphate acyltransferases 290844 Homeodomain 290846 ankyrin repeats 290848 Domain in histone families 1 and 5 290858 Defensin/corticostatin family 290860 Defensin/corticostatin family 290875 Tetratricopeptide repeats 290881 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 290885 Domain abundant in complement control proteins 290885 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 290888 Domain abundant in complement control proteins 290888 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 290890 Domain abundant in complement control proteins 290890 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 290891 Domain abundant in complement control proteins 290892 Domain abundant in complement control proteins 290894 Immunoglobulin 290894 Immunoglobulin C-2 Type 290897 ankyrin repeats 290905 C-terminal tandem repeated domain in type 4 procollagens 290907 breast cancer carboxy-terminal domain 290917 high mobility group 290921 Transforming growth factor-beta (TGF-beta) family 290922 helicase superfamily c-terminal domain 290941 RNA recognition motif 290948 krueppel associated box 290950 krueppel associated box 290951 Tyrosine kinase, catalytic domain 290951 Serine/Threonine protein kinases, catalytic domain 290952 Laminin G domain 290964 krueppel associated box 290965 krueppel associated box 290966 krueppel associated box 290968 krueppel associated box 290970 Papain family cysteine protease 290972 Papain family cysteine protease 290973 Papain family cysteine protease 290974 Papain family cysteine protease 290975 Papain family cysteine protease 290975 Papain family cysteine protease 290976 Papain family cysteine protease 290979 Papain family cysteine protease 290980 Papain family cysteine protease 290981 Papain family cysteine protease 290983 Ubiquitin homologues 290984 zinc finger 290986 Zn_pept domain 290987 Broad-Complex, Tramtrack and Bric a brac 290996 Rab subfamily of small GTPases 290996 Ras subfamily of RAS small GTPases 290996 Rho (Ras homology) subfamily of Ras-like small GTPases 290996 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 291000 UAS domain 291006 Rab subfamily of small GTPases 291006 Ras subfamily of RAS small GTPases 291006 Rho (Ras homology) subfamily of Ras-like small GTPases 291006 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 291014 Tyrosine kinase, catalytic domain 291014 Serine/Threonine protein kinases, catalytic domain 291016 Ubiquitin homologues 291023 helix loop helix domain 291023 helix loop helix domain 291029 Rab subfamily of small GTPases 291029 Ras subfamily of RAS small GTPases 291030 krueppel associated box 291031 RNA recognition motif 291033 C-terminal to LisH motif. 291044 Src homology 3 domains 291078 Serine/Threonine protein kinases, catalytic domain 291079 high mobility group 291085 SERine Proteinase INhibitors 291086 SERine Proteinase INhibitors 291087 SERine Proteinase INhibitors 291089 SERine Proteinase INhibitors 291090 SERine Proteinase INhibitors 291091 SERine Proteinase INhibitors 291097 FORKHEAD 291100 interferon regulatory factor 291113 Histone H3 291118 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 291120 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 291123 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 291130 Domain in the Doublecortin (DCX) gene product 291131 Domain in the Doublecortin (DCX) gene product 291132 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 291141 Histone 2A 291142 Domain in histone families 1 and 5 291143 Histone 2A 291144 Histone 2A 291145 Domain in histone families 1 and 5 291146 Ring finger 291146 Domain in SPla and the RYanodine Receptor. 291147 RNA recognition motif 291147 Tyrosine kinase, catalytic domain 291147 Serine/Threonine protein kinases, catalytic domain 291148 Histone H2B 291149 Histone 2A 291152 Histone H4 291153 Histone 2A 291154 Histone H2B 291155 Histone H3 291156 Domain in histone families 1 and 5 291157 Histone H2B 291158 Histone H2B 291159 Histone H3 291160 Histone 2A 291167 high mobility group 291171 associated with SPRY domains 291171 Domain in SPla and the RYanodine Receptor. 291174 zinc finger 291180 Ependymins 291183 Immunoglobulin 291183 Immunoglobulin V-Type 291184 Immunoglobulin 291184 Immunoglobulin V-Type 291185 Immunoglobulin 291185 Immunoglobulin V-Type 291185 Immunoglobulin C-2 Type 291188 Homeodomain 291220 snRNP Sm proteins 291223 DEAD-like helicases superfamily 291227 Armadillo/beta-catenin-like repeats 291231 Guanine nucleotide exchange factor for Ras-like GTPases 291239 Alpha-lactalbumin / lysozyme C 291252 Domain of unknown function present in FAF1 (Fas-associated factor 1) 291256 Domain of unknown function present in FAF1 (Fas-associated factor 1) 291271 Rab subfamily of small GTPases 291280 minichromosome maintenance proteins 291291 ankyrin repeats 291292 Chromo Shadow Domain 291296 RRM_1 domain 291296 RNA recognition motif 291296 glycine rich nucleic binding domain 291299 RNA recognition motif 291319 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 291327 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 291332 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 291334 Low-density lipoprotein receptor domain class A 291334 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 291335 Low-density lipoprotein receptor domain class A 291335 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 291336 Low-density lipoprotein receptor domain class A 291336 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 291337 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 291340 Armadillo/beta-catenin-like repeats 291345 Tyrosine kinase, catalytic domain 291345 Serine/Threonine protein kinases, catalytic domain 291346 ankyrin repeats 291349 Tyrosine kinase, catalytic domain 291349 Serine/Threonine protein kinases, catalytic domain 291350 Myosin. Large ATPases. ATPase 291350 Tyrosine kinase, catalytic domain 291350 Serine/Threonine protein kinases, catalytic domain 291369 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 291372 Phosphatidylinositol phosphate kinases 291376 Phosphotyrosine-binding domain (IRS1-like) 291379 GTPase-activator protein for Rho-like GTPases 291379 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 291388 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 291414 breast cancer carboxy-terminal domain 291414 catalytic domain of ctd-like phosphatases 291424 Immunoglobulin 291426 Lipoxygenase homology 2 (beta barrel) domain 291427 Lipoxygenase homology 2 (beta barrel) domain 291428 Lipoxygenase homology 2 (beta barrel) domain 291432 Middle domain of eukaryotic initiation factor 4G (eIF4G) 291437 Lipoxygenase homology 2 (beta barrel) domain 291442 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291452 Actin depolymerisation factor/cofilin -like domains 291458 high mobility group 291465 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 291527 in StAR and phosphatidylcholine transfer protein 291538 Thymosin beta actin-binding motif 291541 Domains present in proteins implicated in post-mortem DNA fragmentation 291553 Domain Homologous to E6-AP Carboxyl Terminus with 291564 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 291567 RNA recognition motif 291568 Immunoglobulin 291568 Immunoglobulin C-2 Type 291568 Tyrosine kinase, catalytic domain 291568 Serine/Threonine protein kinases, catalytic domain 291569 Homeodomain 291595 Guanine nucleotide exchange factor for Ras-like GTPases 291596 Guanine nucleotide exchange factor for Ras-like GTPases 291597 B-Box-type zinc finger 291597 B-Box C-terminal domain 291597 Fibronectin type 3 domain 291599 Ubiquitin homologues 291605 Immunoglobulin 291605 Immunoglobulin C-2 Type 291606 prohibitin homologues 291613 GTPase-activator protein for Rho-like GTPases 291614 Src homology 3 domains 291615 RRM_1 domain 291615 RNA recognition motif 291615 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 291618 Broad-Complex, Tramtrack and Bric a brac 291623 Src homology 3 domains 291632 Formin Homology 2 Domain 291635 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291637 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291638 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291639 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291642 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291643 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291644 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291645 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291646 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291647 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291648 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291649 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291651 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291652 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291653 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291654 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291655 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291656 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291658 U1-like zinc finger 291678 found in Wnt-1 291679 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 291680 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 291681 found in Wnt-1 291682 found in Wnt-1 291687 Band 4.1 homologues 291688 Band 4.1 homologues 291690 bromo domain 291691 bromo domain 291692 bromo domain 291697 Band 4.1 homologues 291698 Band 4.1 homologues 291699 in StAR and phosphatidylcholine transfer protein 291701 Ubiquitin homologues 291704 Tyrosine kinase, catalytic domain 291704 Serine/Threonine protein kinases, catalytic domain 291707 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 291708 WD40 repeats 291713 Rab subfamily of small GTPases 291713 Ras subfamily of RAS small GTPases 291713 Rho (Ras homology) subfamily of Ras-like small GTPases 291713 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 291721 RNA recognition motif 291725 Formin Homology 2 Domain 291741 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 291752 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291754 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291759 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291760 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291762 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 291768 prohibitin homologues 291772 Broad-Complex, Tramtrack and Bric a brac 291773 TAF homology 291782 ankyrin repeats 291794 snRNP Sm proteins 291795 RNA polymerase subunit 8 291797 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 291798 RNA recognition motif 291799 ARF-like small GTPases 291802 krueppel associated box 291846 Trypsin-like serine protease 291854 G-protein-coupled receptor proteolytic site domain 291860 Domain in SPla and the RYanodine Receptor. 291861 von Willebrand factor (vWF) type A domain 291875 BPI/LBP/CETP N-terminal domain 291881 snRNP Sm proteins 291885 minichromosome maintenance proteins 291886 Histone H3 291894 Myosin. Large ATPases. ATPase 291902 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 291906 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 291919 Cold shock protein domain 291923 ATPases associated with a variety of cellular activities 291926 Serine/Threonine protein kinases, catalytic domain 291949 GTPase-activator protein for Rho-like GTPases 291950 Histone H3 291951 Rab subfamily of small GTPases 291951 Ras subfamily of RAS small GTPases 291951 Rho (Ras homology) subfamily of Ras-like small GTPases 291965 Broad-Complex, Tramtrack and Bric a brac 291972 snRNP Sm proteins 291985 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291986 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 291988 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 291997 Ribosomal protein L11/L12 291999 Domain Homologous to E6-AP Carboxyl Terminus with 292000 RNA recognition motif 292009 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 292022 DEAD-like helicases superfamily 292022 helicase superfamily c-terminal domain 292026 krueppel associated box 292030 snRNP Sm proteins 292031 Coagulation factor 5/8 C-terminal domain, discoidin domain 292033 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 292035 Thrombospondin type 1 repeats 292036 Found in Skp1 protein family 292041 Domain with 2 conserved Trp (W) residues 292045 Chromatin organization modifier domain 292048 Lipoxygenase homology 2 (beta barrel) domain 292048 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 292049 snRNP Sm proteins 292057 Double-stranded RNA binding motif 292057 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 292060 interferon regulatory factor 292065 Histone H3 292079 Serine/Threonine protein kinases, catalytic domain 292119 Ribosomal protein L11/L12 292124 Zona pellucida (ZP) domain 292126 Kringle domain 292126 Trypsin-like serine protease 292129 Tudor domain 292130 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 292134 RNA recognition motif 292156 BAR domain 292156 Src homology 3 domains 292192 RNA recognition motif 292193 Lysin motif 292203 krueppel associated box 292206 ATPases associated with a variety of cellular activities 292210 Tyrosine kinase, catalytic domain 292210 Serine/Threonine protein kinases, catalytic domain 292214 Tyrosine kinase, catalytic domain 292214 Serine/Threonine protein kinases, catalytic domain 292215 Tyrosine kinase, catalytic domain 292215 Serine/Threonine protein kinases, catalytic domain 292216 Serine/Threonine protein kinases, catalytic domain 292217 Tyrosine kinase, catalytic domain 292217 Serine/Threonine protein kinases, catalytic domain 292220 Serine/Threonine protein kinases, catalytic domain 292221 RIO-like kinase 292221 Ubiquitin associated domain 292221 Tyrosine kinase, catalytic domain 292221 Serine/Threonine protein kinases, catalytic domain 292222 Ubiquitin associated domain 292222 Tyrosine kinase, catalytic domain 292222 Serine/Threonine protein kinases, catalytic domain 292223 RIO-like kinase 292223 Tyrosine kinase, catalytic domain 292223 Serine/Threonine protein kinases, catalytic domain 292224 RIO-like kinase 292224 Tyrosine kinase, catalytic domain 292224 Serine/Threonine protein kinases, catalytic domain 292225 Serine/Threonine protein kinases, catalytic domain 292226 Tyrosine kinase, catalytic domain 292226 Serine/Threonine protein kinases, catalytic domain 292227 RIO-like kinase 292227 Ubiquitin associated domain 292227 Tyrosine kinase, catalytic domain 292227 Serine/Threonine protein kinases, catalytic domain 292232 krueppel associated box 292234 Homeodomain 292236 Protein kinase C conserved region 2 (CalB) 292238 Fibronectin type 3 domain 292255 Tyrosine kinase, catalytic domain 292255 Serine/Threonine protein kinases, catalytic domain 292256 Src homology 3 domains 292257 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 292284 Dual specificity phosphatase, catalytic domain 292284 Protein tyrosine phosphatase, catalytic domain 292284 Protein tyrosine phosphatase, catalytic domain motif 292287 Ubiquitin homologues 292295 RRM_1 domain 292295 RNA recognition motif 292295 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 292297 Histone H3 292301 Domain first found in the mice T locus (Brachyury) protein 292308 Serine/Threonine protein kinases, catalytic domain 292313 Tyrosine kinase, catalytic domain 292313 Serine/Threonine protein kinases, catalytic domain 292314 Serine/Threonine protein kinases, catalytic domain 292316 Tyrosine kinase, catalytic domain 292316 Serine/Threonine protein kinases, catalytic domain 292317 Serine/Threonine protein kinases, catalytic domain 292321 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 292325 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 292327 RNA recognition motif 292332 RIO-like kinase 292332 Ubiquitin associated domain 292332 Tyrosine kinase, catalytic domain 292332 Serine/Threonine protein kinases, catalytic domain 292333 Ubiquitin associated domain 292334 RIO-like kinase 292334 Tyrosine kinase, catalytic domain 292334 Serine/Threonine protein kinases, catalytic domain 292335 RIO-like kinase 292335 Ubiquitin associated domain 292335 Tyrosine kinase, catalytic domain 292335 Serine/Threonine protein kinases, catalytic domain 292336 RIO-like kinase 292336 Tyrosine kinase, catalytic domain 292336 Serine/Threonine protein kinases, catalytic domain 292338 Ubiquitin associated domain 292338 Tyrosine kinase, catalytic domain 292338 Serine/Threonine protein kinases, catalytic domain 292340 Ubiquitin associated domain 292340 Tyrosine kinase, catalytic domain 292340 Serine/Threonine protein kinases, catalytic domain 292342 RIO-like kinase 292342 Tyrosine kinase, catalytic domain 292342 Serine/Threonine protein kinases, catalytic domain 292343 RIO-like kinase 292343 Tyrosine kinase, catalytic domain 292343 Serine/Threonine protein kinases, catalytic domain 292345 Serine/Threonine protein kinases, catalytic domain 292346 Tyrosine kinase, catalytic domain 292346 Serine/Threonine protein kinases, catalytic domain 292347 Serine/Threonine protein kinases, catalytic domain 292348 RIO-like kinase 292348 Tyrosine kinase, catalytic domain 292348 Serine/Threonine protein kinases, catalytic domain 292350 Ubiquitin associated domain 292350 Serine/Threonine protein kinases, catalytic domain 292351 RIO-like kinase 292351 Tyrosine kinase, catalytic domain 292351 Serine/Threonine protein kinases, catalytic domain 292352 Tyrosine kinase, catalytic domain 292352 Serine/Threonine protein kinases, catalytic domain 292353 Tyrosine kinase, catalytic domain 292353 Serine/Threonine protein kinases, catalytic domain 292354 RIO-like kinase 292354 Tyrosine kinase, catalytic domain 292354 Serine/Threonine protein kinases, catalytic domain 292355 RIO-like kinase 292355 Tyrosine kinase, catalytic domain 292355 Serine/Threonine protein kinases, catalytic domain 292356 Serine/Threonine protein kinases, catalytic domain 292357 RIO-like kinase 292357 Tyrosine kinase, catalytic domain 292357 Serine/Threonine protein kinases, catalytic domain 292358 RIO-like kinase 292358 Ubiquitin associated domain 292358 Tyrosine kinase, catalytic domain 292358 Serine/Threonine protein kinases, catalytic domain 292360 RIO-like kinase 292360 Tyrosine kinase, catalytic domain 292360 Serine/Threonine protein kinases, catalytic domain 292361 Serine/Threonine protein kinases, catalytic domain 292362 Serine/Threonine protein kinases, catalytic domain 292363 Ubiquitin associated domain 292363 Tyrosine kinase, catalytic domain 292363 Serine/Threonine protein kinases, catalytic domain 292364 Tyrosine kinase, catalytic domain 292364 Serine/Threonine protein kinases, catalytic domain 292365 Ubiquitin associated domain 292365 Tyrosine kinase, catalytic domain 292365 Serine/Threonine protein kinases, catalytic domain 292366 RIO-like kinase 292366 Tyrosine kinase, catalytic domain 292366 Serine/Threonine protein kinases, catalytic domain 292367 RIO-like kinase 292367 Tyrosine kinase, catalytic domain 292367 Serine/Threonine protein kinases, catalytic domain 292368 RIO-like kinase 292368 Tyrosine kinase, catalytic domain 292368 Serine/Threonine protein kinases, catalytic domain 292369 Serine/Threonine protein kinases, catalytic domain 292371 RIO-like kinase 292371 Ubiquitin associated domain 292371 Tyrosine kinase, catalytic domain 292371 Serine/Threonine protein kinases, catalytic domain 292372 RIO-like kinase 292372 Tyrosine kinase, catalytic domain 292372 Serine/Threonine protein kinases, catalytic domain 292375 Serine/Threonine protein kinases, catalytic domain 292376 RIO-like kinase 292376 Tyrosine kinase, catalytic domain 292376 Serine/Threonine protein kinases, catalytic domain 292377 RIO-like kinase 292377 Tyrosine kinase, catalytic domain 292377 Serine/Threonine protein kinases, catalytic domain 292384 krueppel associated box 292386 RIO-like kinase 292386 Tyrosine kinase, catalytic domain 292386 Serine/Threonine protein kinases, catalytic domain 292387 Tyrosine kinase, catalytic domain 292387 Serine/Threonine protein kinases, catalytic domain 292388 RIO-like kinase 292388 Tyrosine kinase, catalytic domain 292388 Serine/Threonine protein kinases, catalytic domain 292389 RIO-like kinase 292389 Tyrosine kinase, catalytic domain 292389 Serine/Threonine protein kinases, catalytic domain 292391 RIO-like kinase 292391 Ubiquitin associated domain 292391 Tyrosine kinase, catalytic domain 292391 Serine/Threonine protein kinases, catalytic domain 292393 RIO-like kinase 292393 Ubiquitin associated domain 292393 Tyrosine kinase, catalytic domain 292393 Serine/Threonine protein kinases, catalytic domain 292394 RIO-like kinase 292394 Tyrosine kinase, catalytic domain 292394 Serine/Threonine protein kinases, catalytic domain 292395 RIO-like kinase 292395 Tyrosine kinase, catalytic domain 292395 Serine/Threonine protein kinases, catalytic domain 292396 RIO-like kinase 292396 Tyrosine kinase, catalytic domain 292396 Serine/Threonine protein kinases, catalytic domain 292399 Tyrosine kinase, catalytic domain 292399 Serine/Threonine protein kinases, catalytic domain 292404 PHD zinc finger 292405 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 292423 Tyrosine kinase, catalytic domain 292423 Serine/Threonine protein kinases, catalytic domain 292426 krueppel associated box 292430 krueppel associated box 292436 krueppel associated box 292437 krueppel associated box 292442 krueppel associated box 292443 krueppel associated box 292467 erythroblast transformation specific domain 292473 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 292476 DEAD-like helicases superfamily 292478 Rab subfamily of small GTPases 292478 Ras subfamily of RAS small GTPases 292478 Rho (Ras homology) subfamily of Ras-like small GTPases 292478 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 292479 Dual specificity phosphatase, catalytic domain 292483 Syntaxin N-terminal domain 292483 Helical region found in SNAREs 292489 krueppel associated box 292494 krueppel associated box 292516 Actin 292537 Immunoglobulin 292537 Immunoglobulin C-2 Type 292548 krueppel associated box 292551 krueppel associated box 292552 krueppel associated box 292554 Tyrosine kinase, catalytic domain 292554 Serine/Threonine protein kinases, catalytic domain 292564 krueppel associated box 292566 leucine rich region 292572 Tyrosine kinase, catalytic domain 292572 Serine/Threonine protein kinases, catalytic domain 292573 Homeodomain 292574 Homeodomain 292575 Homeodomain 292578 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 292579 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 292581 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 292583 associated with SPRY domains 292583 Domain in SPla and the RYanodine Receptor. 292585 Tyrosine kinase, catalytic domain 292585 Serine/Threonine protein kinases, catalytic domain 292588 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 292593 Protein present in Fab1, YOTB, Vac1, and EEA1 292601 leucine rich region 292602 leucine rich region 292603 Tyrosine kinase, catalytic domain 292603 Serine/Threonine protein kinases, catalytic domain 292610 krueppel associated box 292617 leucine rich region 292620 krueppel associated box 292627 Ubiquitin homologues 292628 Homeodomain 292629 Homeodomain 292630 Homeodomain 292631 RNA recognition motif 292639 Pentraxin / C-reactive protein / pentaxin family 292639 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 292645 Cytoplasmic phospholipase A2, catalytic subunit 292646 Fibronectin type 2 domain 292647 Homeodomain 292653 Immunoglobulin 292653 Immunoglobulin C-2 Type 292658 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 292659 Serine/Threonine protein kinases, catalytic domain 292664 Immunoglobulin 292664 Immunoglobulin C-2 Type 292667 Immunoglobulin 292667 Immunoglobulin C-2 Type 292681 K homology RNA-binding domain 292686 A Receptor for Ubiquitination Targets 292688 snRNP Sm proteins 292701 Immunoglobulin 292701 Immunoglobulin C-2 Type 292703 krueppel associated box 292704 high mobility group 292705 krueppel associated box 292719 Doublesex DNA-binding motif 292720 erythroblast transformation specific domain 292721 erythroblast transformation specific domain 292729 RNA recognition motif 292738 Phospholipase D. Active site motifs. Phosphatidylcholine-hydrolyzing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of cert 292740 krueppel associated box 292741 Cold shock protein domain 292742 krueppel associated box 292744 Low molecular weight phosphatase family 292745 von Willebrand factor (vWF) type D domain 292746 von Willebrand factor (vWF) type D domain 292756 P21-Rho-binding domain 292756 Tyrosine kinase, catalytic domain 292756 Serine/Threonine protein kinases, catalytic domain 292760 Domain present in VPS9 292761 RNA recognition motif 292763 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 292770 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 292773 krueppel associated box 292774 krueppel associated box 292775 krueppel associated box 292778 C2C2 Zinc finger 292778 RNA polymerase subunit 9 292782 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 292784 Immunoglobulin 292784 Immunoglobulin C-2 Type 292799 krueppel associated box 292801 Uteroglobin 292807 Broad-Complex, Tramtrack and Bric a brac 292809 WD40 repeats 292821 krueppel associated box 292822 krueppel associated box 292826 krueppel associated box 292827 krueppel associated box 292830 A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins 292831 A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins 292841 Histone 2A 292841 krueppel associated box 292842 krueppel associated box 292843 Immunoglobulin 292843 Immunoglobulin C-2 Type 292846 Immunoglobulin 292846 Immunoglobulin V-Type 292846 Immunoglobulin C-2 Type 292848 Trypsin-like serine protease 292849 Trypsin-like serine protease 292851 Trypsin-like serine protease 292852 Trypsin-like serine protease 292853 Trypsin-like serine protease 292855 Trypsin-like serine protease 292856 Trypsin-like serine protease 292857 Trypsin-like serine protease 292858 Trypsin-like serine protease 292859 Trypsin-like serine protease 292861 Trypsin-like serine protease 292862 Trypsin-like serine protease 292863 Trypsin-like serine protease 292864 Trypsin-like serine protease 292865 Trypsin-like serine protease 292866 Trypsin-like serine protease 292867 Trypsin-like serine protease 292868 Trypsin-like serine protease 292868 Trypsin-like serine protease 292870 Trypsin-like serine protease 292871 Trypsin-like serine protease 292872 Trypsin-like serine protease 292873 Trypsin-like serine protease 292879 Immunoglobulin 292879 Immunoglobulin C-2 Type 292879 Fibronectin type 3 domain 292881 erythroblast transformation specific domain 292884 krueppel associated box 292894 Modified RING finger domain 292906 RNA recognition motif 292910 Ras association (RalGDS/AF-6) domain 292917 Band 4.1 homologues 292918 von Willebrand factor (vWF) type D domain 292918 C-terminal cystine knot-like domain (CTCK) 292919 helix loop helix domain 292922 Serum amyloid A proteins 292924 Serum amyloid A proteins 292925 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 292932 Calponin homology domain 292934 Homeodomain 292944 Eps15 homology domain 292947 Sec7 domain 292948 Tyrosine kinase, catalytic domain 292948 Serine/Threonine protein kinases, catalytic domain 292952 domain in Ataxins and HMG containing proteins 292959 domain in Ataxins and HMG containing proteins 292978 Trypsin-like serine protease 292979 Histone H3 292983 Rab subfamily of small GTPases 292983 Ras subfamily of RAS small GTPases 292983 Rho (Ras homology) subfamily of Ras-like small GTPases 292992 RNA recognition motif 292993 WD40 repeats 292994 Domain present in ZO-1 and Unc5-like netrin receptors 293001 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 293012 helix loop helix domain 293015 Tyrosine kinase, catalytic domain 293015 Serine/Threonine protein kinases, catalytic domain 293020 Zn_pept domain 293023 Kelch domain 293023 Broad-Complex, Tramtrack and Bric a brac 293027 Histone 2A 293028 DNA Topoisomerase I (eukaryota) 293035 RNA recognition motif 293039 leucine rich region 293041 Tyrosine kinase, catalytic domain 293041 Serine/Threonine protein kinases, catalytic domain 293046 helix loop helix domain 293049 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 293052 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 293056 RNA recognition motif 293067 A20-like zinc fingers 293067 AN1-like Zinc finger 293100 Trypsin-like serine protease 293106 Rab subfamily of small GTPases 293106 Rho (Ras homology) subfamily of Ras-like small GTPases 293121 14-3-3 homologues 293150 in StAR and phosphatidylcholine transfer protein 293157 DNA-binding domain of DNA mismatch repair MUTS family 293162 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 293165 high mobility group 293179 TEA domain 293181 Ricin-type beta-trefoil 293186 Link (Hyaluronan-binding) 293190 BCL (B-Cell lymphoma) 293190 BH4 Bcl-2 homology region 4 293211 high mobility group 293286 Ubiquitin homologues 293287 Ubiquitin homologues 293288 Olfactomedin-like domains 293293 associated with SPRY domains 293293 Domain in SPla and the RYanodine Receptor. 293294 B-Box-type zinc finger 293294 B-Box C-terminal domain 293294 Domain in SPla and the RYanodine Receptor. 293296 Ring finger 293296 B-Box-type zinc finger 293298 Ring finger 293298 B-Box-type zinc finger 293298 Domain in SPla and the RYanodine Receptor. 293410 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 293420 high mobility group 293427 JAB/MPN domain 293462 leucine rich region 293462 krueppel associated box 293484 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 293493 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 293499 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 293505 Contains conserved Gly-Tyr-Phe residues 293508 Tyrosine kinase, catalytic domain 293508 Serine/Threonine protein kinases, catalytic domain 293509 krueppel associated box 293511 krueppel associated box 293516 Trypsin-like serine protease 293519 von Willebrand factor (vWF) type A domain 293519 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 293520 von Willebrand factor (vWF) type A domain 293520 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 293523 Domain with 2 conserved Trp (W) residues 293525 Immunoglobulin 293525 Immunoglobulin C-2 Type 293533 Scavenger receptor Cys-rich 293534 Zona pellucida (ZP) domain 293534 Scavenger receptor Cys-rich 293534 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 293537 Homeodomain 293538 Homeodomain 293560 high mobility group 293561 Ring finger 293567 Actin depolymerisation factor/cofilin -like domains 293568 Homeodomain 293572 high mobility group 293573 Zinc-dependent metalloprotease 293578 ig-like, plexins, transcription factors 293613 Transthyretin 293616 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 293621 Rab subfamily of small GTPases 293621 Ras subfamily of RAS small GTPases 293621 Rho (Ras homology) subfamily of Ras-like small GTPases 293621 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 293625 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 293628 Glyco_18 domain 293631 RIO-like kinase 293631 Tyrosine kinase, catalytic domain 293631 Serine/Threonine protein kinases, catalytic domain 293637 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 293654 Protein kinase C conserved region 2 (CalB) 293660 Rab subfamily of small GTPases 293660 Ras subfamily of RAS small GTPases 293660 Rho (Ras homology) subfamily of Ras-like small GTPases 293660 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 293661 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 293662 RNA recognition motif 293663 RNA recognition motif 293666 Ribosomal protein L11/L12 293670 ARF-like small GTPases 293670 Rab subfamily of small GTPases 293670 Ras subfamily of RAS small GTPases 293670 Rho (Ras homology) subfamily of Ras-like small GTPases 293670 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 293673 eukaryotic translation initiation factor 1A 293691 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 293692 Eps15 homology domain 293693 Tyrosine kinase, catalytic domain 293693 Extension to Ser/Thr-type protein kinases 293693 Serine/Threonine protein kinases, catalytic domain 293693 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 293693 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 293693 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 293694 Tyrosine kinase, catalytic domain 293694 Serine/Threonine protein kinases, catalytic domain 293694 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 293695 Guanine nucleotide exchange factor for Ras-like GTPases 293696 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 293701 Ligand binding domain of hormone receptors 293710 Galectin 293719 Domain present in ubiquitin-regulatory proteins 293737 Histone H3 293747 domain present in translation initiation factor eIF2B and eIF5 293747 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 293782 zinc finger 293783 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 293798 tob/btg1 family 293823 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 293831 RNA recognition motif 293836 high mobility group 293837 EF-hand, calcium binding motif 293839 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 293842 DnaJ molecular chaperone homology domain 293843 krueppel associated box 293847 Protein tyrosine phosphatase, catalytic domain 293847 Dual specificity phosphatase, catalytic domain 293856 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 293861 Phosphate acyltransferases 293864 Ubiquitin homologues 293867 RRM_1 domain 293867 RNA recognition motif 293884 Acid phosphatase homologues 293906 Alkaline phosphatase homologues 293909 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 293913 heat shock factor 293917 RNA recognition motif 293935 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 293939 prohibitin homologues 293940 Src homology 3 domains 293943 Guanine nucleotide exchange factor for Ras-like GTPases 293944 Guanine nucleotide exchange factor for Ras-like GTPases 293946 Laminin G domain 293946 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 293947 GTPase-activator protein for Rho-like GTPases 293958 Cystatin-like domain 293960 A20-like zinc fingers 293960 AN1-like Zinc finger 293976 Doublesex DNA-binding motif 293990 found in Wnt-1 293996 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 293997 Immunoglobulin 293997 Immunoglobulin C-2 Type 293998 Homeodomain 294000 Homeodomain 294001 Homeodomain 294007 RNA recognition motif 294018 WD40 repeats 294022 Src homology 3 domains 294023 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 294041 VPS10 domain 294042 VPS10 domain 294043 VPS10 domain 294051 DNA polymerase X family 294053 domain present in cyclins, TFIIB and Retinoblastoma 294065 Broad-Complex, Tramtrack and Bric a brac 294081 Ubiquitin homologues 294093 ankyrin repeats 294115 high mobility group 294116 Eps15 homology domain 294116 EF-hand, calcium binding motif 294119 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at present 294153 krueppel associated box 294208 Ring finger 294208 B-Box-type zinc finger 294208 associated with SPRY domains 294208 Domain in SPla and the RYanodine Receptor. 294209 Ring finger 294210 Ring finger 294210 B-Box-type zinc finger 294210 B-Box C-terminal domain 294210 associated with SPRY domains 294210 Domain in SPla and the RYanodine Receptor. 294211 Immunoglobulin C-Type 294212 Immunoglobulin C-Type 294213 Immunoglobulin C-Type 294225 Immunoglobulin C-Type 294228 Immunoglobulin C-Type 294238 Immunoglobulin C-Type 294248 glycine rich nucleic binding domain 294252 DNA-binding domain of DNA mismatch repair MUTS family 294256 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 294257 Trypsin-like serine protease 294258 RNA recognition motif 294262 Fibrinogen-related domains (FReDs) 294266 Netrin C-terminal Domain 294269 Immunoglobulin C-Type 294270 Immunoglobulin C-Type 294271 Immunoglobulin C-Type 294272 ATPases associated with a variety of cellular activities 294274 Immunoglobulin C-Type 294277 Immunoglobulin C-Type 294278 Immunoglobulin C-Type 294279 Fibrillar collagens C-terminal domain 294283 Ras association (RalGDS/AF-6) domain 294286 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 294289 Broad-Complex, Tramtrack and Bric a brac 294293 SAM / Pointed domain 294293 erythroblast transformation specific domain 294295 U1-like zinc finger 294297 Calcium-binding EGF-like domain 294297 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 294302 Colipase 294307 Broad-Complex, Tramtrack and Bric a brac 294309 RNA recognition motif 294312 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 294314 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 294328 SAND domain 294328 PHD zinc finger 294331 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 294335 von Willebrand factor (vWF) type D domain 294336 K homology RNA-binding domain 294337 von Willebrand factor (vWF) type A domain 294347 GTPase-activator protein for Rho-like GTPases 294352 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 294362 CDGSH-type zinc finger. Function unknown 294384 "FY-rich" domain, N-terminal region 294391 Armadillo/beta-catenin-like repeats 294406 minichromosome maintenance proteins 294413 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 294415 Histone H3 294420 Actin depolymerisation factor/cofilin -like domains 294423 Homeodomain 294424 Homeodomain 294425 Homeodomain 294426 Homeodomain 294427 Homeodomain 294428 Homeodomain 294429 Ran-binding domain 294440 Laminin G domain 294440 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 294443 Ring finger 294453 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 294458 Homeodomain 294459 Homeodomain 294460 Homeodomain 294461 Homeodomain 294462 Homeodomain 294463 Homeodomain 294464 Homeodomain 294465 Homeodomain 294466 Homeodomain 294467 Homeodomain 294468 Homeodomain 294469 Homeodomain 294470 Homeodomain 294471 Homeodomain 294472 Homeodomain 294473 Homeodomain 294474 Homeodomain 294475 Homeodomain 294476 Homeodomain 294477 Homeodomain 294478 Homeodomain 294479 Homeodomain 294480 Homeodomain 294481 Homeodomain 294482 Homeodomain 294483 Homeodomain 294484 Homeodomain 294485 Homeodomain 294486 Homeodomain 294487 Homeodomain 294488 Homeodomain 294489 Homeodomain 294490 Homeodomain 294491 Homeodomain 294492 Homeodomain 294493 Homeodomain 294494 Homeodomain 294495 Homeodomain 294496 Homeodomain 294497 Homeodomain 294498 Homeodomain 294503 Transforming growth factor-beta (TGF-beta) family 294515 FORKHEAD 294535 Domain Homologous to E6-AP Carboxyl Terminus with 294545 Tyrosine kinase, catalytic domain 294545 Serine/Threonine protein kinases, catalytic domain 294559 Zona pellucida (ZP) domain 294562 Homeodomain 294562 Found in Pit-Oct-Unc transcription factors 294566 Found in Skp1 protein family 294568 Wiskott Aldrich syndrome homology region 2 294569 Laminin-type epidermal growth factor-like domai 294570 Homeodomain 294571 Homeodomain 294572 Homeodomain 294573 Homeodomain 294574 Homeodomain 294575 Homeodomain 294576 Homeodomain 294577 Homeodomain 294578 Homeodomain 294579 Homeodomain 294580 Homeodomain 294581 Homeodomain 294582 Homeodomain 294583 Homeodomain 294584 Homeodomain 294585 Homeodomain 294586 Homeodomain 294587 Homeodomain 294588 Homeodomain 294589 Homeodomain 294600 RNA recognition motif 294606 Homeodomain 294606 Found in Pit-Oct-Unc transcription factors 294607 Ligand binding domain of hormone receptors 294617 Domain present in ubiquitin-regulatory proteins 294640 Homeodomain 294642 snRNP Sm proteins 294647 ankyrin repeats 294650 ATPase domain of DNA mismatch repair MUTS family 294650 DNA-binding domain of DNA mismatch repair MUTS family 294657 Calcium-binding EGF-like domain 294657 Epidermal growth factor-like domain 294657 Domain abundant in complement control proteins 294657 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 294668 ankyrin repeats 294674 Kelch domain 294679 ankyrin repeats 294689 Baculoviral inhibition of apoptosis protein repeat 294690 Baculoviral inhibition of apoptosis protein repeat 294691 Baculoviral inhibition of apoptosis protein repeat 294693 von Willebrand factor (vWF) type A domain 294695 Serine/Threonine protein kinases, catalytic domain 294704 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 294705 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 294706 Leucine rich repeat C-terminal domain 294707 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 294708 Tetratricopeptide repeats 294717 Ring finger 294718 Ribosomal RNA adenine dimethylases 294737 ankyrin repeats 294739 Fibronectin type 3 domain 294741 helicase superfamily c-terminal domain 294746 Trypsin-like serine protease 294771 Caspase recruitment domain 294773 snRNP Sm proteins 294776 erythroblast transformation specific domain 294780 Fibronectin type 3 domain 294790 A Receptor for Ubiquitination Targets 294795 EF-hand, calcium binding motif 294806 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 294809 ADAM Cysteine-Rich Domain 294809 Thrombospondin type 1 repeats 294812 domain in DSRM or ZnF_C2H2 domain containing proteins 294814 Ribonuclease III family 294814 Double-stranded RNA binding motif 294829 high mobility group 294831 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 294856 Actin 294861 Armadillo/beta-catenin-like repeats 294871 krueppel associated box 294872 krueppel associated box 294873 krueppel associated box 294874 krueppel associated box 294875 krueppel associated box 294884 RNA recognition motif 294887 GTPase-activator protein for Rho-like GTPases 294892 GTPase-activator protein for Rho-like GTPases 294894 eukaryotic translation initiation factor 1A 294913 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 294917 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 294919 Calcium-binding EGF-like domain 294920 Calcium-binding EGF-like domain 294941 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 294946 Rab subfamily of small GTPases 294946 Ras subfamily of RAS small GTPases 294947 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 294952 K homology RNA-binding domain 294954 helix loop helix domain 294962 WD40 repeats 294979 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 294983 Galectin 294990 DEAD-like helicases superfamily 295010 RNA recognition motif 295011 Histone H3 295013 GTPase-activator protein for Rho-like GTPases 295014 GTPase-activator protein for Rho-like GTPases 295015 GTPase-activator protein for Rho-like GTPases 295022 GTPase-activator protein for Rho-like GTPases 295023 GTPase-activator protein for Rho-like GTPases 295024 GTPase-activator protein for Rho-like GTPases 295025 GTPase-activator protein for Rho-like GTPases 295026 GTPase-activator protein for Rho-like GTPases 295027 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 295030 snRNP Sm proteins 295034 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 295041 prohibitin homologues 295047 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 295052 domain present in cyclins, TFIIB and Retinoblastoma 295054 helix loop helix domain 295066 Ring finger 295080 RNA recognition motif 295084 Src homology 3 domains 295092 GTPase-activator protein for Rho-like GTPases 295117 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 295123 JAB/MPN domain 295124 JAB/MPN domain 295133 Immunoglobulin 295133 Immunoglobulin C-2 Type 295133 Kazal type serine protease inhibitors 295145 Low-density lipoprotein receptor domain class A 295159 EF-hand, calcium binding motif 295162 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 295165 WD40 repeats 295171 Src homology 3 domains 295173 Ami_2 domain 295173 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 295175 Ami_2 domain 295175 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 295180 Ami_2 domain 295180 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 295192 WD40 repeats 295195 EF-hand, calcium binding motif 295199 meprin and TRAF homology 295199 Broad-Complex, Tramtrack and Bric a brac 295200 Broad-Complex, Tramtrack and Bric a brac 295201 Broad-Complex, Tramtrack and Bric a brac 295202 Broad-Complex, Tramtrack and Bric a brac 295209 EF-hand, calcium binding motif 295214 EF-hand, calcium binding motif 295227 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 295228 glycine rich nucleic binding domain 295239 PHD zinc finger 295239 Bromo adjacent homology domain 295240 Serine/Threonine protein kinases, catalytic domain 295250 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 295251 PHD zinc finger 295252 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 295254 Broad-Complex, Tramtrack and Bric a brac 295255 meprin and TRAF homology 295255 Broad-Complex, Tramtrack and Bric a brac 295256 meprin and TRAF homology 295256 Broad-Complex, Tramtrack and Bric a brac 295258 meprin and TRAF homology 295258 Broad-Complex, Tramtrack and Bric a brac 295259 Immunoglobulin 295259 Immunoglobulin C-2 Type 295259 Leucine-rich repeats, typical (most populated) subfamily 295262 Lysin motif 295263 ankyrin repeats 295268 Ubiquitin homologues 295272 Histone 2A 295273 Histone 2A 295274 Histone H2B 295277 Histone H4 295278 Histone H2B 295279 Immunoglobulin 295279 Immunoglobulin C-2 Type 295284 RNA recognition motif 295285 Link (Hyaluronan-binding) 295288 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 295292 Tyrosine kinase, catalytic domain 295292 Serine/Threonine protein kinases, catalytic domain 295294 RNA recognition motif 295296 erythroblast transformation specific domain 295297 Immunoglobulin 295297 Immunoglobulin C-2 Type 295298 high mobility group 295309 ADAM Cysteine-Rich Domain 295309 Homologues of snake disintegrins 295314 Domain first found in the mice T locus (Brachyury) protein 295322 Immunoglobulin 295322 Immunoglobulin V-Type 295322 Immunoglobulin C-2 Type 295323 Filamin-type immunoglobulin domains 295324 helicase superfamily c-terminal domain 295325 Immunoglobulin 295325 Immunoglobulin V-Type 295327 helix loop helix domain 295329 Ligand binding domain of hormone receptors 295329 c4 zinc finger in nuclear hormone receptors 295335 bromo domain 295341 Serine/threonine phosphatases, family 2C, catalytic domain 295342 Rab subfamily of small GTPases 295342 Ras subfamily of RAS small GTPases 295342 Rho (Ras homology) subfamily of Ras-like small GTPases 295342 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 295346 DEAD-like helicases superfamily 295347 Rab subfamily of small GTPases 295347 Ras subfamily of RAS small GTPases 295347 Rho (Ras homology) subfamily of Ras-like small GTPases 295347 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 295349 Glyco_18 domain 295350 Glyco_18 domain 295350 Calcium-binding EGF-like domain 295350 Epidermal growth factor-like domain 295351 Glyco_18 domain 295352 Glyco_18 domain 295360 Broad-Complex, Tramtrack and Bric a brac 295361 Src homology 3 domains 295365 Immunoglobulin 295367 Laminin G domain 295367 Calcium-binding EGF-like domain 295367 Domain present in hormone receptors 295367 Laminin-type epidermal growth factor-like domai 295367 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 295370 WD40 repeats 295376 Calponin homology domain 295378 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 295378 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 295380 Laminin-type epidermal growth factor-like domai 295381 Laminin-type epidermal growth factor-like domai 295382 Laminin N-terminal domain (domain VI) 295387 U1-like zinc finger 295388 Aamy_C domain 295388 Alpha-amylase domain 295389 Domain with 2 conserved Trp (W) residues 295390 RNA recognition motif 295401 Acid phosphatase homologues 295403 Acid phosphatase homologues 295429 Ubiquitin homologues 295437 GTPase-activator protein for Rho-like GTPases 295444 Actin 295446 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 295448 PHD zinc finger 295449 BAR domain 295449 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 295450 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 295457 CDGSH-type zinc finger. Function unknown 295461 Gelsolin homology domain 295475 helix loop helix domain 295481 GTPase-activator protein for Rho-like GTPases 295503 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 295509 Ring finger 295511 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 295518 Src homology 2 domains 295523 Tyrosine kinase, catalytic domain 295523 Extension to Ser/Thr-type protein kinases 295523 Serine/Threonine protein kinases, catalytic domain 295523 Protein kinase C-related kinase homology region 1 homologues 295526 Homeodomain 295529 14-3-3 homologues 295530 Tyrosine kinase, catalytic domain 295530 Serine/Threonine protein kinases, catalytic domain 295531 Tyrosine kinase, catalytic domain 295531 ankyrin repeats 295531 Tyrosine kinase, catalytic domain 295531 Serine/Threonine protein kinases, catalytic domain 295538 Domain found in Dishevelled, Egl-10, and Pleckstrin 295541 ATPase domain of DNA mismatch repair MUTS family 295541 DNA-binding domain of DNA mismatch repair MUTS family 295546 Domain in ubiquitin-specific proteases 295553 Eps15 homology domain 295553 EF-hand, calcium binding motif 295561 domain involved in Ras-like GTPase signaling 295567 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 295568 helicase superfamily c-terminal domain 295570 GTPase-activator protein for Rho-like GTPases 295576 Broad-Complex, Tramtrack and Bric a brac 295577 meprin and TRAF homology 295577 Broad-Complex, Tramtrack and Bric a brac 295580 meprin and TRAF homology 295580 Broad-Complex, Tramtrack and Bric a brac 295581 meprin and TRAF homology 295581 Broad-Complex, Tramtrack and Bric a brac 295582 Broad-Complex, Tramtrack and Bric a brac 295585 meprin and TRAF homology 295585 Broad-Complex, Tramtrack and Bric a brac 295586 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 295588 Rab subfamily of small GTPases 295588 Ras subfamily of RAS small GTPases 295588 Rho (Ras homology) subfamily of Ras-like small GTPases 295588 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 295590 Ubiquitin homologues 295603 Src homology 3 domains 295603 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 295607 Contains two conserved F residues 295609 Ubiquitin homologues 295610 Glyco_18 domain 295610 Ubiquitin homologues 295611 RNA recognition motif 295614 Histidine kinase-like ATPases 295627 Modified RING finger domain 295628 Methyl-CpG binding domain 295630 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 295631 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 295632 Integrin beta subunits (N-terminal portion of extracellular region) 295633 RNA recognition motif 295635 GTPase-activator protein for Rho-like GTPases 295640 WD40 repeats 295641 DEAD-like helicases superfamily 295644 JAB/MPN domain 295649 ATPases associated with a variety of cellular activities 295660 domain present in translation initiation factor eIF2B and eIF5 295662 Actin depolymerisation factor/cofilin -like domains 295666 Tyrosine kinase, catalytic domain 295666 Serine/Threonine protein kinases, catalytic domain 295667 Ubiquitin homologues 295669 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 295676 Immunoglobulin 295676 Immunoglobulin C-2 Type 295678 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 295680 U1-like zinc finger 295684 high mobility group 295686 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 295691 Frizzled 295691 Netrin C-terminal Domain 295700 Rab subfamily of small GTPases 295700 Ras subfamily of RAS small GTPases 295700 Rho (Ras homology) subfamily of Ras-like small GTPases 295703 SERine Proteinase INhibitors 295704 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 295706 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 295873 SERine Proteinase INhibitors 295925 RNA recognition motif 295929 Immunoglobulin 295929 Immunoglobulin C-2 Type 295948 RNA recognition motif 295954 Ring finger 295957 Low-density lipoprotein receptor domain class A 295965 erythroblast transformation specific domain 295966 SAM / Pointed domain 295966 erythroblast transformation specific domain 295972 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 295975 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 295980 Domain in the Doublecortin (DCX) gene product 295986 Src homology 2 domains 295988 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 295999 ankyrin repeats 296057 Actin depolymerisation factor/cofilin -like domains 296058 Formin Homology 2 Domain 296060 GTPase-activator protein for Rho-like GTPases 296072 WASP homology region 1 296075 Tyrosine kinase, catalytic domain 296075 Serine/Threonine protein kinases, catalytic domain 296078 P21-Rho-binding domain 296078 Tyrosine kinase, catalytic domain 296078 Serine/Threonine protein kinases, catalytic domain 296079 Bromo adjacent homology domain 296082 ATPases associated with a variety of cellular activities 296083 Clathrin heavy chain repeat homology 296084 DEAD-like helicases superfamily 296091 Protein kinase C conserved region 2 (CalB) 296091 Cytoplasmic phospholipase A2, catalytic subunit 296094 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 296099 breast cancer carboxy-terminal domain 296113 RNA recognition motif 296126 Domain of unknown function in Sec63p, Brr2p and other proteins 296129 Zinc-dependent metalloprotease 296133 krueppel associated box 296149 Immunoglobulin C-Type 296150 Ribosomal protein L11/L12 296152 Transglutaminase/protease-like homologues 296156 Zn_pept domain 296165 Ribosomal protein L11/L12 296175 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 296176 high mobility group 296179 Band 4.1 homologues 296197 Actin depolymerisation factor/cofilin -like domains 296218 RNA recognition motif 296220 Cystatin-like domain 296221 Cystatin-like domain 296222 Cystatin-like domain 296223 Cystatin-like domain 296226 Cystatin-like domain 296229 Cystatin-like domain 296230 Cystatin-like domain 296232 Cystatin-like domain 296234 Cystatin-like domain 296235 Cystatin-like domain 296240 BCL (B-Cell lymphoma) 296243 Serine/Threonine protein kinases, catalytic domain 296246 krueppel associated box 296248 krueppel associated box 296249 Histone H3 296250 Ubiquitin associated domain 296250 Tyrosine kinase, catalytic domain 296250 Serine/Threonine protein kinases, catalytic domain 296256 Tyrosine kinase, catalytic domain 296256 Serine/Threonine protein kinases, catalytic domain 296258 Cystatin-like domain 296265 Serine/Threonine protein kinases, catalytic domain 296266 ig-like, plexins, transcription factors 296269 Fibrinogen-related domains (FReDs) 296271 ParB-like nuclease domain 296272 helix loop helix domain 296290 BPI/LBP/CETP C-terminal domain 296293 TAF homology 296295 Actin 296296 EF-hand, calcium binding motif 296298 snRNP Sm proteins 296301 RNA recognition motif 296302 domain present in translation initiation factor eIF2B and eIF5 296305 Zinc-dependent metalloprotease 296307 Protein kinase C conserved region 2 (CalB) 296308 RRM_1 domain 296310 leucine rich region 296313 EF-hand, calcium binding motif 296314 Homeodomain 296316 EF-hand, calcium binding motif 296321 BPI/LBP/CETP C-terminal domain 296321 BPI/LBP/CETP N-terminal domain 296323 GTPase-activator protein for Rho-like GTPases 296326 ankyrin repeats 296331 Protein tyrosine phosphatase, catalytic domain 296332 Protein tyrosine phosphatase, catalytic domain 296332 Protein tyrosine phosphatase, catalytic domain motif 296333 Protein tyrosine phosphatase, catalytic domain 296339 RNA recognition motif 296349 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 296351 RNA recognition motif 296351 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 296356 Four-disulfide core domains 296357 Four-disulfide core domains 296358 von Willebrand factor (vWF) type A domain 296368 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 296369 Eps15 homology domain 296371 BPI/LBP/CETP C-terminal domain 296377 snRNP Sm proteins 296390 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 296395 Broad-Complex, Tramtrack and Bric a brac 296402 Phosphotyrosine-binding domain (IRS1-like) 296409 Src homology 3 domains 296416 Ubiquitin homologues 296417 ankyrin repeats 296418 Gelsolin homology domain 296420 Ubiquitin homologues 296423 krueppel associated box 296424 krueppel associated box 296425 krueppel associated box 296426 krueppel associated box 296427 krueppel associated box 296428 krueppel associated box 296429 krueppel associated box 296431 krueppel associated box 296432 krueppel associated box 296433 krueppel associated box 296434 krueppel associated box 296436 krueppel associated box 296437 krueppel associated box 296438 krueppel associated box 296440 krueppel associated box 296441 krueppel associated box 296444 krueppel associated box 296446 krueppel associated box 296460 Laminin G domain 296466 C-terminal to LisH motif. 296466 Lissencephaly type-1-like homology motif 296471 Tyrosine kinase, catalytic domain 296472 Src homology 2 domains 296472 Src homology 3 domains 296472 Tyrosine kinase, catalytic domain 296472 Serine/Threonine protein kinases, catalytic domain 296475 DEAD-like helicases superfamily 296478 glycine rich nucleic binding domain 296485 C2C2 Zinc finger 296485 RNA polymerase subunit 9 296497 Guanine nucleotide exchange factor for Ras-like small GTPases 296498 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 296499 Homeodomain 296503 Ubiquitin homologues 296505 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 296508 Integrin beta subunits (N-terminal portion of extracellular region) 296511 Homeodomain 296513 RNA recognition motif 296515 Cystatin-like domain 296516 Cystatin-like domain 296517 helix loop helix domain 296521 krueppel associated box 296522 krueppel associated box 296525 GTPase-activator protein for Rho-like GTPases 296526 Ubiquitin homologues 296532 meprin and TRAF homology 296532 Broad-Complex, Tramtrack and Bric a brac 296537 K homology RNA-binding domain 296539 C2C2 Zinc finger 296539 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 296540 Interleukin-1 homologues 296541 Interleukin-1 homologues 296570 Helix-turn-helix XRE-family like proteins 296581 Ubiquitin associated domain 296603 Calponin homology domain 296614 Spectrin repeats 296619 Tyrosine kinase, catalytic domain 296619 Serine/Threonine protein kinases, catalytic domain 296624 Acid phosphatase homologues 296627 ankyrin repeats 296627 suppressors of cytokine signalling 296635 Acid phosphatase homologues 296644 Ribosomal protein L11/L12 296645 Guanine nucleotide exchange factor for Ras-like small GTPases 296646 Broad-Complex, Tramtrack and Bric a brac 296654 Gelsolin homology domain 296655 prohibitin homologues 296695 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 296697 Ubiquitin homologues 296698 Ubiquitin homologues 296699 Ubiquitin homologues 296702 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 296706 Homeodomain 296706 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 296708 Olfactomedin-like domains 296716 Low-density lipoprotein-receptor YWTD domain 296717 Low-density lipoprotein-receptor YWTD domain 296718 Calcium-binding EGF-like domain 296718 Epidermal growth factor-like domain 296718 Low-density lipoprotein-receptor YWTD domain 296719 Low-density lipoprotein receptor domain class A 296721 high mobility group 296724 RNA recognition motif 296730 Beta/gamma crystallins 296734 ankyrin repeats 296735 ankyrin repeats 296739 Rab subfamily of small GTPases 296739 Ras subfamily of RAS small GTPases 296748 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 296764 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 296770 krueppel associated box 296787 semaphorin domain 296787 domain found in Plexins, Semaphorins and Integrins 296788 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 296789 semaphorin domain 296789 domain found in Plexins, Semaphorins and Integrins 296790 semaphorin domain 296804 semaphorin domain 296817 Ran-binding domain 296823 high mobility group 296826 Tyrosine kinase, catalytic domain 296826 Serine/Threonine protein kinases, catalytic domain 296827 Tyrosine kinase, catalytic domain 296827 Serine/Threonine protein kinases, catalytic domain 296846 Immunoglobulin 296846 Immunoglobulin C-2 Type 296849 Histidine kinase-like ATPases 296852 Gelsolin homology domain 296878 prohibitin homologues 296889 domain in high mobilty group proteins HMG14 and HMG 17 296891 Rab subfamily of small GTPases 296894 PHD zinc finger 296897 Thrombospondin type 1 repeats 296907 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 296912 found in Wnt-1 296913 snRNP Sm proteins 296918 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 296923 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins 296927 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 296930 Ring finger 296934 suppressors of cytokine signalling 296936 Wiskott Aldrich syndrome homology region 2 296940 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 296948 Tissue inhibitor of metalloproteinase family. Form complexes with metalloproteinases, such as collagenases, and irreversibly inactivate them 296951 Filamin-type immunoglobulin domains 296956 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 296959 Zn_pept domain 296960 Zn_pept domain 296968 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 296980 Rab subfamily of small GTPases 296980 Ras subfamily of RAS small GTPases 296980 Rho (Ras homology) subfamily of Ras-like small GTPases 296984 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 296985 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 296987 high mobility group 296989 zinc finger 296991 Tyrosine kinase, catalytic domain 296991 Serine/Threonine protein kinases, catalytic domain 296993 Tyrosine kinase, catalytic domain 296996 Tyrosine kinase, catalytic domain 296996 Serine/Threonine protein kinases, catalytic domain 297000 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297002 Trypsin-like serine protease 297003 Trypsin-like serine protease 297004 Immunoglobulin 297004 Immunoglobulin V-Type 297005 Immunoglobulin 297005 Immunoglobulin V-Type 297009 Immunoglobulin V-Type 297010 Immunoglobulin 297010 Immunoglobulin V-Type 297011 Immunoglobulin V-Type 297012 Immunoglobulin 297012 Immunoglobulin V-Type 297013 Immunoglobulin V-Type 297014 Immunoglobulin V-Type 297015 Immunoglobulin 297015 Immunoglobulin V-Type 297016 Immunoglobulin 297016 Immunoglobulin V-Type 297017 Immunoglobulin 297017 Immunoglobulin V-Type 297018 Immunoglobulin 297018 Immunoglobulin V-Type 297019 Immunoglobulin V-Type 297020 Immunoglobulin 297020 Immunoglobulin V-Type 297022 Immunoglobulin 297022 Immunoglobulin V-Type 297023 Immunoglobulin 297023 Immunoglobulin V-Type 297031 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 297053 Homeodomain 297056 Coagulation factor 5/8 C-terminal domain, discoidin domain 297058 Coagulation factor 5/8 C-terminal domain, discoidin domain 297061 Laminin G domain 297062 Laminin G domain 297066 krueppel associated box 297068 Immunoglobulin 297068 Immunoglobulin C-2 Type 297069 von Willebrand factor (vWF) type D domain 297072 Thrombospondin type 1 repeats 297072 von Willebrand factor (vWF) type D domain 297072 Low-density lipoprotein receptor domain class A 297072 Coagulation factor 5/8 C-terminal domain, discoidin domain 297083 K homology RNA-binding domain 297087 Tyrosine kinase, catalytic domain 297087 Serine/Threonine protein kinases, catalytic domain 297090 Serine/Threonine protein kinases, catalytic domain 297093 Chromo Shadow Domain 297093 Chromatin organization modifier domain 297096 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 297099 Homeodomain 297100 Homeodomain 297150 Domain Homologous to E6-AP Carboxyl Terminus with 297155 Domain Homologous to E6-AP Carboxyl Terminus with 297160 Laminin G domain 297165 high mobility group 297168 RNA recognition motif 297173 Rho (Ras homology) subfamily of Ras-like small GTPases 297173 Rab subfamily of small GTPases 297173 Ras subfamily of RAS small GTPases 297173 Rho (Ras homology) subfamily of Ras-like small GTPases 297173 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 297174 Cold shock protein domain 297175 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 297180 Immunoglobulin 297180 Immunoglobulin V-Type 297181 Immunoglobulin 297181 Immunoglobulin V-Type 297182 Immunoglobulin 297182 Immunoglobulin V-Type 297183 Immunoglobulin 297183 Immunoglobulin V-Type 297183 Immunoglobulin C-2 Type 297184 Immunoglobulin 297184 Immunoglobulin V-Type 297185 Immunoglobulin 297185 Immunoglobulin V-Type 297185 Immunoglobulin C-2 Type 297186 Immunoglobulin 297186 Immunoglobulin V-Type 297187 Immunoglobulin 297187 Immunoglobulin V-Type 297188 Immunoglobulin 297188 Immunoglobulin V-Type 297189 Immunoglobulin 297189 Immunoglobulin V-Type 297190 Immunoglobulin 297190 Immunoglobulin V-Type 297191 Immunoglobulin 297191 Immunoglobulin V-Type 297193 Immunoglobulin 297193 Immunoglobulin V-Type 297197 Immunoglobulin 297197 Immunoglobulin V-Type 297199 Immunoglobulin 297199 Immunoglobulin V-Type 297200 Immunoglobulin 297201 Immunoglobulin 297201 Immunoglobulin V-Type 297202 Immunoglobulin 297202 Immunoglobulin V-Type 297203 Immunoglobulin 297203 Immunoglobulin V-Type 297204 Immunoglobulin 297204 Immunoglobulin V-Type 297206 Immunoglobulin V-Type 297207 Immunoglobulin 297207 Immunoglobulin V-Type 297208 Immunoglobulin 297208 Immunoglobulin V-Type 297209 Immunoglobulin 297209 Immunoglobulin V-Type 297210 Immunoglobulin 297210 Immunoglobulin V-Type 297211 Immunoglobulin 297211 Immunoglobulin V-Type 297213 Immunoglobulin 297213 Immunoglobulin V-Type 297214 Immunoglobulin 297214 Immunoglobulin V-Type 297215 Immunoglobulin 297215 Immunoglobulin V-Type 297216 Immunoglobulin 297216 Immunoglobulin V-Type 297217 Immunoglobulin 297217 Immunoglobulin V-Type 297218 Immunoglobulin 297218 Immunoglobulin V-Type 297218 Immunoglobulin C-2 Type 297219 Immunoglobulin 297219 Immunoglobulin V-Type 297220 Immunoglobulin 297220 Immunoglobulin V-Type 297221 Immunoglobulin 297221 Immunoglobulin V-Type 297221 Immunoglobulin C-2 Type 297222 Immunoglobulin V-Type 297223 Immunoglobulin 297223 Immunoglobulin V-Type 297224 Immunoglobulin 297224 Immunoglobulin V-Type 297225 Immunoglobulin 297225 Immunoglobulin V-Type 297226 Immunoglobulin 297226 Immunoglobulin V-Type 297228 Immunoglobulin 297228 Immunoglobulin V-Type 297229 Immunoglobulin 297229 Immunoglobulin V-Type 297230 Immunoglobulin 297230 Immunoglobulin V-Type 297231 Immunoglobulin 297231 Immunoglobulin V-Type 297232 Immunoglobulin 297232 Immunoglobulin V-Type 297233 Immunoglobulin 297233 Immunoglobulin V-Type 297234 Immunoglobulin 297234 Immunoglobulin V-Type 297235 Immunoglobulin 297235 Immunoglobulin V-Type 297236 Immunoglobulin 297236 Immunoglobulin V-Type 297237 Immunoglobulin 297237 Immunoglobulin V-Type 297239 Immunoglobulin 297239 Immunoglobulin V-Type 297240 Immunoglobulin 297240 Immunoglobulin V-Type 297241 Immunoglobulin 297241 Immunoglobulin V-Type 297242 Immunoglobulin V-Type 297243 Immunoglobulin 297243 Immunoglobulin V-Type 297245 Immunoglobulin 297245 Immunoglobulin V-Type 297246 Immunoglobulin 297246 Immunoglobulin V-Type 297247 Immunoglobulin 297247 Immunoglobulin V-Type 297248 Immunoglobulin 297248 Immunoglobulin V-Type 297249 Immunoglobulin 297249 Immunoglobulin V-Type 297250 Immunoglobulin 297250 Immunoglobulin V-Type 297251 Immunoglobulin 297251 Immunoglobulin V-Type 297252 Immunoglobulin 297254 Immunoglobulin 297254 Immunoglobulin V-Type 297255 Immunoglobulin 297255 Immunoglobulin V-Type 297256 Immunoglobulin 297256 Immunoglobulin V-Type 297257 Immunoglobulin V-Type 297258 Immunoglobulin 297258 Immunoglobulin V-Type 297259 Immunoglobulin 297259 Immunoglobulin V-Type 297260 Immunoglobulin 297260 Immunoglobulin V-Type 297261 Immunoglobulin 297261 Immunoglobulin V-Type 297262 Immunoglobulin 297262 Immunoglobulin V-Type 297262 Immunoglobulin C-2 Type 297263 Immunoglobulin 297263 Immunoglobulin V-Type 297264 Immunoglobulin 297264 Immunoglobulin V-Type 297264 Immunoglobulin C-2 Type 297266 Immunoglobulin 297266 Immunoglobulin V-Type 297267 Immunoglobulin 297267 Immunoglobulin V-Type 297268 Immunoglobulin 297268 Immunoglobulin V-Type 297269 Immunoglobulin 297269 Immunoglobulin C-2 Type 297270 Immunoglobulin 297270 Immunoglobulin V-Type 297272 Immunoglobulin 297272 Immunoglobulin V-Type 297272 Immunoglobulin C-2 Type 297274 Immunoglobulin 297274 Immunoglobulin V-Type 297275 Immunoglobulin 297275 Immunoglobulin V-Type 297276 Immunoglobulin 297277 Immunoglobulin V-Type 297278 Immunoglobulin 297278 Immunoglobulin V-Type 297279 Immunoglobulin 297279 Immunoglobulin V-Type 297280 Immunoglobulin 297280 Immunoglobulin V-Type 297282 Immunoglobulin 297282 Immunoglobulin V-Type 297283 Immunoglobulin 297283 Immunoglobulin V-Type 297284 Immunoglobulin 297284 Immunoglobulin V-Type 297285 Immunoglobulin 297285 Immunoglobulin V-Type 297286 Immunoglobulin 297286 Immunoglobulin V-Type 297287 Immunoglobulin 297287 Immunoglobulin V-Type 297288 Immunoglobulin 297288 Immunoglobulin V-Type 297288 Immunoglobulin C-2 Type 297289 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 297290 Immunoglobulin 297290 Immunoglobulin V-Type 297292 Immunoglobulin 297292 Immunoglobulin V-Type 297293 Immunoglobulin 297293 Immunoglobulin V-Type 297294 Immunoglobulin 297294 high mobility group 297294 Immunoglobulin V-Type 297295 Immunoglobulin 297295 Immunoglobulin V-Type 297297 Immunoglobulin V-Type 297299 Immunoglobulin 297299 Immunoglobulin V-Type 297300 Immunoglobulin 297300 Immunoglobulin V-Type 297301 Immunoglobulin V-Type 297303 Immunoglobulin 297303 Immunoglobulin V-Type 297304 Immunoglobulin 297304 Immunoglobulin V-Type 297305 Immunoglobulin 297305 Immunoglobulin V-Type 297306 Immunoglobulin 297306 Immunoglobulin V-Type 297307 Immunoglobulin 297307 Immunoglobulin V-Type 297308 Immunoglobulin 297308 Immunoglobulin V-Type 297309 Immunoglobulin 297309 Immunoglobulin V-Type 297311 Immunoglobulin 297311 Immunoglobulin V-Type 297311 Immunoglobulin C-2 Type 297312 Immunoglobulin 297312 Immunoglobulin V-Type 297314 Immunoglobulin 297314 Immunoglobulin V-Type 297315 Immunoglobulin 297315 Immunoglobulin V-Type 297316 Immunoglobulin 297316 Immunoglobulin V-Type 297316 Immunoglobulin C-2 Type 297317 Immunoglobulin 297317 Immunoglobulin V-Type 297318 Immunoglobulin 297318 Immunoglobulin V-Type 297320 Immunoglobulin 297320 Immunoglobulin V-Type 297321 Immunoglobulin 297321 Immunoglobulin V-Type 297322 Immunoglobulin 297322 Immunoglobulin V-Type 297323 Immunoglobulin 297323 Immunoglobulin V-Type 297324 Immunoglobulin 297324 Immunoglobulin V-Type 297325 Immunoglobulin 297325 Immunoglobulin V-Type 297326 Immunoglobulin 297326 Immunoglobulin V-Type 297328 Immunoglobulin 297328 Immunoglobulin V-Type 297330 Immunoglobulin 297330 Immunoglobulin V-Type 297331 FORKHEAD 297337 Ring finger 297338 Src homology 2 domains 297339 Gelsolin homology domain 297348 RNA recognition motif 297352 high mobility group 297353 RNA recognition motif 297374 Ubiquitin homologues 297376 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 297377 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 297379 Homeodomain 297391 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297396 U1-like zinc finger 297401 Tyrosine kinase, catalytic domain 297401 Serine/Threonine protein kinases, catalytic domain 297405 Homeodomain 297413 helix loop helix domain 297420 Pulmonary surfactant proteins 297421 Transforming growth factor-beta (TGF-beta) family 297423 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 297425 ARF-like small GTPases 297425 Rab subfamily of small GTPases 297425 Ras subfamily of RAS small GTPases 297425 Rho (Ras homology) subfamily of Ras-like small GTPases 297425 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 297427 ARF-like small GTPases 297432 ankyrin repeats 297432 Broad-Complex, Tramtrack and Bric a brac 297449 GTPase-activator protein for Rho-like GTPases 297452 Ubiquitin homologues 297455 snRNP Sm proteins 297463 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 297470 Kelch domain 297480 FORKHEAD 297488 Ring finger 297488 Modified RING finger domain 297488 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 297494 Armadillo/beta-catenin-like repeats 297503 ARF-like small GTPases 297503 Rab subfamily of small GTPases 297503 Sar1p-like members of the Ras-family of small GTPases 297522 WD40 repeats 297526 zinc finger 297528 Domain in histone families 1 and 5 297548 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 297555 Tyrosine kinase, catalytic domain 297555 Serine/Threonine protein kinases, catalytic domain 297555 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 297558 Leucine rich repeat N-terminal domain 297563 ARID (A/T-rich interaction domain) domain 297573 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297577 Transforming growth factor-beta (TGF-beta) family 297580 Homeodomain 297584 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297585 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297586 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297587 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297592 suppressors of cytokine signalling 297592 Domain in SPla and the RYanodine Receptor. 297595 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 297596 Immunoglobulin 297602 Immunoglobulin 297602 Immunoglobulin V-Type 297602 Immunoglobulin C-Type 297611 domain present in cyclins, TFIIB and Retinoblastoma 297626 TEA domain 297632 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297633 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297634 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297635 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297637 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297639 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297640 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297641 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297642 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297645 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297646 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297647 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297648 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297649 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297650 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297651 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297652 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297654 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297656 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297657 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297659 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297661 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297664 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297665 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297666 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297667 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297668 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 297670 Tyrosine kinase, catalytic domain 297670 Serine/Threonine protein kinases, catalytic domain 297682 Protein tyrosine phosphatase, catalytic domain 297682 Dual specificity phosphatase, catalytic domain 297682 Protein tyrosine phosphatase, catalytic domain motif 297683 Rhodanese Homology Domain 297685 DEAD-like helicases superfamily 297690 Histone H3 297697 Histone H4 297699 WD40 repeats 297702 Rab subfamily of small GTPases 297702 Ras subfamily of RAS small GTPases 297702 Rho (Ras homology) subfamily of Ras-like small GTPases 297703 Phospholipase C, catalytic domain (part) 297703 Protein kinase C conserved region 2 (CalB) 297704 Phospholipase C, catalytic domain (part) 297730 Orange domain 297731 prohibitin homologues 297743 c4 zinc finger in nuclear hormone receptors 297765 prohibitin homologues 297769 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 297772 Cold shock protein domain 297791 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 297796 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 297798 Regulator of G protein signalling domain 297806 Protein tyrosine phosphatase, catalytic domain 297806 Dual specificity phosphatase, catalytic domain 297806 Protein tyrosine phosphatase, catalytic domain motif 297827 krueppel associated box 297831 EF-hand, calcium binding motif 297832 Laminin G domain 297835 Coagulation factor 5/8 C-terminal domain, discoidin domain 297836 Coagulation factor 5/8 C-terminal domain, discoidin domain 297844 krueppel associated box 297845 RNA recognition motif 297846 Laminin G domain 297847 Laminin G domain 297848 Laminin G domain 297848 Coagulation factor 5/8 C-terminal domain, discoidin domain 297850 Guanine nucleotide exchange factor for Ras-like GTPases 297851 Coagulation factor 5/8 C-terminal domain, discoidin domain 297852 Histidine kinase-like ATPases 297853 high mobility group 297863 Src homology 3 domains 297875 Histone H3 297880 Domain abundant in complement control proteins 297882 Ring finger 297889 Broad-Complex, Tramtrack and Bric a brac 297891 Tyrosine kinase, catalytic domain 297891 Serine/Threonine protein kinases, catalytic domain 297892 snRNP Sm proteins 297897 RNA recognition motif 297902 Rab subfamily of small GTPases 297902 Ras subfamily of RAS small GTPases 297902 Rho (Ras homology) subfamily of Ras-like small GTPases 297902 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 297906 Guanine nucleotide exchange factor for Ras-like GTPases 297909 DnaJ molecular chaperone homology domain 297916 Tyrosine kinase, catalytic domain 297916 Serine/Threonine protein kinases, catalytic domain 297919 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 297920 domain present in translation initiation factor eIF2B and eIF5 297920 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 297927 high mobility group 297930 Domain Homologous to E6-AP Carboxyl Terminus with 297934 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 297936 Histone H3 297940 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 297949 leucine rich region 297954 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 297988 Trypsin-like serine protease 297992 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 297994 Ubiquitin homologues 297994 BAG domains, present in regulator of Hsp70 proteins 297996 Ubiquitin homologues 298004 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 298006 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 298012 Ubiquitin associated domain 298013 Ubiquitin associated domain 298017 Actin 298021 Band 4.1 homologues 298025 Calcium-binding EGF-like domain 298025 Domain abundant in complement control proteins 298026 von Willebrand factor (vWF) type A domain 298031 Calcium-binding EGF-like domain 298031 Domain abundant in complement control proteins 298033 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 298062 Acid phosphatase homologues 298078 Immunoglobulin 298084 Broad-Complex, Tramtrack and Bric a brac 298087 krueppel associated box 298088 krueppel associated box 298095 WD40 repeats 298095 Splicing Factor Motif, present in Prp18 and Pr04 298101 Fibrillar collagens C-terminal domain 298108 krueppel associated box 298110 krueppel associated box 298111 krueppel associated box 298113 krueppel associated box 298115 krueppel associated box 298123 Histone 2A 298135 krueppel associated box 298137 Rab subfamily of small GTPases 298137 Ras subfamily of RAS small GTPases 298137 Rho (Ras homology) subfamily of Ras-like small GTPases 298158 WD40 repeats 298159 WD40 repeats 298161 high mobility group 298172 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins 298173 krueppel associated box 298180 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 298194 Thrombospondin type 1 repeats 298196 Thrombospondin type 1 repeats 298197 Immunoglobulin 298197 Immunoglobulin C-2 Type 298197 Thrombospondin type 1 repeats 298198 Immunoglobulin 298198 Immunoglobulin C-2 Type 298198 Thrombospondin type 1 repeats 298203 prohibitin homologues 298205 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298206 RNA recognition motif 298207 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298208 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298209 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298210 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298211 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298212 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298213 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298214 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298215 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298216 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298217 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298219 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298220 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298221 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298222 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298223 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298224 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298225 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 298238 high mobility group 298247 JAB/MPN domain 298248 basic region leucin zipper 298257 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 298288 membrane-attack complex / perforin 298289 Ubiquitin homologues 298302 in StAR and phosphatidylcholine transfer protein 298306 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 298316 glycine rich nucleic binding domain 298316 Putative single-stranded nucleic acids-binding domain 298317 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 298319 Ubiquitin homologues 298321 Histone H3 298322 Ring finger 298326 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 298327 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 298328 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 298331 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 298332 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 298336 domain present in translation initiation factor eIF2B and eIF5 298336 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 298338 Zinc finger domain 298339 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 298344 Homeodomain 298345 Homeodomain 298346 Homeodomain 298347 Homeodomain 298348 Rab subfamily of small GTPases 298348 Ras subfamily of RAS small GTPases 298348 Rho (Ras homology) subfamily of Ras-like small GTPases 298348 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 298349 tob/btg1 family 298352 Homeodomain 298353 Homeodomain 298359 RNA recognition motif 298360 RNA recognition motif 298361 RNA recognition motif 298362 RNA recognition motif 298387 Immunoglobulin 298387 Immunoglobulin V-Type 298392 Kelch domain 298392 Broad-Complex, Tramtrack and Bric a brac 298404 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 298405 Immunoglobulin 298405 Immunoglobulin V-Type 298416 Histone H3 298418 Histone H3 298420 Histone H3 298428 helicase superfamily c-terminal domain 298429 helicase superfamily c-terminal domain 298439 Kelch domain 298439 Broad-Complex, Tramtrack and Bric a brac 298461 RIO-like kinase 298461 Ubiquitin associated domain 298461 Tyrosine kinase, catalytic domain 298461 Serine/Threonine protein kinases, catalytic domain 298485 Immunoglobulin 298485 Immunoglobulin V-Type 298485 associated with SPRY domains 298485 Domain in SPla and the RYanodine Receptor. 298494 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 298506 helix loop helix domain 298510 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 298519 14-3-3 homologues 298521 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 298521 Bacterial periplasmic substrate-binding proteins 298521 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 298528 Tyrosine kinase, catalytic domain 298528 Serine/Threonine protein kinases, catalytic domain 298528 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 298542 Cold shock protein domain 298546 U1-like zinc finger 298558 krueppel associated box 298559 C2C2 Zinc finger 298559 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 298566 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 298567 Trypsin-like serine protease 298568 Low-density lipoprotein receptor domain class A 298569 Ubiquitin homologues 298570 LGN motif, putative GEFs specific for G-alpha GTPases 298573 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 298574 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 298575 Tyrosine kinase, catalytic domain 298575 Serine/Threonine protein kinases, catalytic domain 298576 Ring finger 298577 Domain present in ubiquitin-regulatory proteins 298578 Phospholipase A2 298579 Phospholipase A2 298590 Kelch domain 298591 Immunoglobulin C-2 Type 298628 krueppel associated box 298629 krueppel associated box 298635 krueppel associated box 298639 Serine/Threonine protein kinases, catalytic domain 298640 krueppel associated box 298642 krueppel associated box 298644 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 298648 RNA recognition motif 298668 B-Box C-terminal domain 298673 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 298674 Ring finger 298679 Serine/Threonine protein kinases, catalytic domain 298683 Fibronectin type 3 domain 298683 von Willebrand factor (vWF) type A domain 298684 ankyrin repeats 298686 domain present in cyclins, TFIIB and Retinoblastoma 298689 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 298693 Ubiquitin homologues 298696 Domain with 2 conserved Trp (W) residues 298698 Fibrinogen-related domains (FReDs) 298704 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 298706 RIO-like kinase 298706 Band 4.1 homologues 298706 Src homology 2 domains 298706 Tyrosine kinase, catalytic domain 298706 Serine/Threonine protein kinases, catalytic domain 298713 Histone H3 298719 WD40 repeats 298724 ATPases associated with a variety of cellular activities 298730 tob/btg1 family 298735 RIO-like kinase 298735 Tyrosine kinase, catalytic domain 298735 Serine/Threonine protein kinases, catalytic domain 298736 RIO-like kinase 298736 Tyrosine kinase, catalytic domain 298736 Serine/Threonine protein kinases, catalytic domain 298739 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 298740 Domain present in ubiquitin-regulatory proteins 298746 RNA recognition motif 298763 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 298766 zinc finger 298783 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 298788 high mobility group 298795 14-3-3 homologues 298802 Protein tyrosine phosphatase, catalytic domain motif 298805 Forkhead associated domain 298839 DnaJ molecular chaperone homology domain 298842 WD40 repeats 298848 Calponin homology domain 298850 Histone H3 298857 Domain present in hormone receptors 298857 G-protein-coupled receptor proteolytic site domain 298859 ARF-like small GTPases 298859 Rab subfamily of small GTPases 298859 Ras subfamily of RAS small GTPases 298859 DnaJ molecular chaperone homology domain 298859 Sar1p-like members of the Ras-family of small GTPases 298859 Rho (Ras homology) subfamily of Ras-like small GTPases 298859 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 298863 Src homology 3 domains 298864 Profilin 298866 Rab subfamily of small GTPases 298867 Kelch domain 298867 Broad-Complex, Tramtrack and Bric a brac 298871 Tudor domain 298874 Pumilio-like repeats 298883 Xeroderma pigmentosum G I-region 298883 Xeroderma pigmentosum G N-region 298894 helix loop helix domain 298901 RNA recognition motif 298908 Broad-Complex, Tramtrack and Bric a brac 298912 Fibrinogen-related domains (FReDs) 298913 Putative GTP-ase activating proteins for the small GTPase, ARF 298914 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 298919 snRNP Sm proteins 298924 In Between Ring fingers 298940 RNA recognition motif 298946 Phosphoinositide 3-kinase, catalytic domain 298947 PI3-kinase family, Ras-binding domain 298947 Phosphoinositide 3-kinase, catalytic domain 298947 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 298947 Phosphoinositide 3-kinase, region postulated to contain C2 domain 298950 helix loop helix domain 298956 Domain associated with PX domains 298981 Homeodomain 298982 C-terminal to LisH motif. 298982 Lissencephaly type-1-like homology motif 298988 DnaJ molecular chaperone homology domain 298992 K homology RNA-binding domain 298992 K homology RNA-binding domain 298994 Armadillo/beta-catenin-like repeats 298996 bromo domain 299002 Domain Homologous to E6-AP Carboxyl Terminus with 299009 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 299013 helix loop helix domain 299015 PAS domain 299025 14-3-3 homologues 299026 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 299032 RNA recognition motif 299035 Phosphatidylinositol phosphate kinases 299036 Broad-Complex, Tramtrack and Bric a brac 299040 Tyrosine kinase, catalytic domain 299040 Serine/Threonine protein kinases, catalytic domain 299047 Profilin 299058 Homeodomain 299061 Homeodomain 299064 Homeodomain 299069 Domain associated with PX domains 299070 Ubiquitin homologues 299087 RRM_1 domain 299087 RNA recognition motif 299103 Kelch domain 299103 Broad-Complex, Tramtrack and Bric a brac 299116 Domain with 2 conserved Trp (W) residues 299121 Actin 299136 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 299138 Homeodomain 299142 Protein kinase C conserved region 2 (CalB) 299144 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 299145 Rab subfamily of small GTPases 299145 Ras subfamily of RAS small GTPases 299145 Rho (Ras homology) subfamily of Ras-like small GTPases 299145 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 299146 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology 299156 ARF-like small GTPases 299156 Rab subfamily of small GTPases 299156 Ras subfamily of RAS small GTPases 299156 Rho (Ras homology) subfamily of Ras-like small GTPases 299156 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 299158 domain present in translation initiation factor eIF2B and eIF5 299168 Histone H3 299169 Bromodomain transcription factors and PHD domain containing proteins 299172 RNA recognition motif 299172 DnaJ molecular chaperone homology domain 299178 Phospholipase A2 299184 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 299185 PHD zinc finger 299188 Protein present in Fab1, YOTB, Vac1, and EEA1 299189 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 299197 Filamin-type immunoglobulin domains 299197 Domain Homologous to E6-AP Carboxyl Terminus with 299198 Large family of predicted nucleotide-binding domains 299202 Serine/Threonine protein kinases, catalytic domain 299206 basic region leucin zipper 299210 Ligand binding domain of hormone receptors 299210 c4 zinc finger in nuclear hormone receptors 299212 RNA recognition motif 299236 Leucine rich repeat C-terminal domain 299241 Actin depolymerisation factor/cofilin -like domains 299255 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 299267 helicase superfamily c-terminal domain 299270 SERine Proteinase INhibitors 299271 SERine Proteinase INhibitors 299272 SERine Proteinase INhibitors 299273 SERine Proteinase INhibitors 299274 SERine Proteinase INhibitors 299275 SERine Proteinase INhibitors 299276 SERine Proteinase INhibitors 299277 SERine Proteinase INhibitors 299278 SERine Proteinase INhibitors 299279 SERine Proteinase INhibitors 299280 SERine Proteinase INhibitors 299281 SERine Proteinase INhibitors 299282 SERine Proteinase INhibitors 299283 SERine Proteinase INhibitors 299284 Ribonuclease III family 299285 Calponin homology domain 299302 krueppel associated box 299303 krueppel associated box 299304 krueppel associated box 299307 Histone H3 299309 FORKHEAD 299317 WD40 repeats 299326 snRNP Sm proteins 299331 Histidine kinase-like ATPases 299332 Tyrosine kinase, catalytic domain 299332 Serine/Threonine protein kinases, catalytic domain 299343 Tudor domain 299343 DEAD-like helicases superfamily 299351 Immunoglobulin C-Type 299352 Immunoglobulin C-Type 299354 Immunoglobulin C-Type 299355 Immunoglobulin C-Type 299357 Immunoglobulin C-Type 299358 Immunoglobulin C-Type 299360 Immunoglobulin 299360 Immunoglobulin V-Type 299361 Immunoglobulin V-Type 299362 Immunoglobulin 299362 Immunoglobulin V-Type 299363 Immunoglobulin 299363 Immunoglobulin V-Type 299364 Immunoglobulin 299364 Immunoglobulin V-Type 299365 Immunoglobulin V-Type 299366 Immunoglobulin 299366 Immunoglobulin V-Type 299367 Immunoglobulin 299367 Immunoglobulin V-Type 299368 Immunoglobulin 299368 Immunoglobulin V-Type 299369 Immunoglobulin 299369 Immunoglobulin V-Type 299370 Immunoglobulin 299370 Immunoglobulin V-Type 299371 Immunoglobulin 299371 Immunoglobulin V-Type 299372 Immunoglobulin 299372 Immunoglobulin V-Type 299373 Immunoglobulin V-Type 299374 Immunoglobulin V-Type 299375 Immunoglobulin 299375 Immunoglobulin V-Type 299376 Immunoglobulin 299376 Immunoglobulin V-Type 299377 Immunoglobulin V-Type 299378 Immunoglobulin V-Type 299379 Immunoglobulin V-Type 299380 Immunoglobulin V-Type 299381 Immunoglobulin V-Type 299382 Immunoglobulin 299382 Immunoglobulin V-Type 299383 Immunoglobulin V-Type 299384 Immunoglobulin 299384 Immunoglobulin V-Type 299385 Immunoglobulin V-Type 299386 Immunoglobulin 299386 Immunoglobulin V-Type 299388 Immunoglobulin 299388 Immunoglobulin V-Type 299389 Immunoglobulin 299389 Immunoglobulin V-Type 299390 Immunoglobulin 299390 Immunoglobulin V-Type 299391 Immunoglobulin 299391 Immunoglobulin V-Type 299393 Immunoglobulin 299393 Immunoglobulin V-Type 299394 Immunoglobulin 299394 Immunoglobulin V-Type 299395 Immunoglobulin 299395 Immunoglobulin V-Type 299396 Immunoglobulin V-Type 299397 Immunoglobulin 299397 Immunoglobulin V-Type 299398 Immunoglobulin 299398 Immunoglobulin V-Type 299400 Immunoglobulin 299400 Immunoglobulin V-Type 299401 Immunoglobulin V-Type 299402 Immunoglobulin 299402 Immunoglobulin V-Type 299403 Immunoglobulin V-Type 299404 Immunoglobulin 299404 Immunoglobulin V-Type 299405 Immunoglobulin 299405 Immunoglobulin V-Type 299406 Immunoglobulin 299406 Immunoglobulin V-Type 299407 Immunoglobulin 299407 Immunoglobulin V-Type 299408 Immunoglobulin V-Type 299409 Immunoglobulin 299409 Immunoglobulin V-Type 299410 Immunoglobulin V-Type 299411 Immunoglobulin 299411 Immunoglobulin V-Type 299412 Immunoglobulin 299412 Immunoglobulin V-Type 299413 Immunoglobulin 299413 Immunoglobulin V-Type 299414 Immunoglobulin V-Type 299416 Immunoglobulin 299416 Immunoglobulin V-Type 299417 Immunoglobulin 299417 Immunoglobulin V-Type 299418 Immunoglobulin 299418 Immunoglobulin V-Type 299419 Immunoglobulin V-Type 299420 Immunoglobulin 299420 Immunoglobulin V-Type 299421 Immunoglobulin V-Type 299422 Immunoglobulin 299422 Immunoglobulin V-Type 299423 Immunoglobulin 299423 Immunoglobulin V-Type 299424 Immunoglobulin V-Type 299426 Immunoglobulin 299426 Immunoglobulin V-Type 299428 Immunoglobulin 299428 Immunoglobulin V-Type 299429 Immunoglobulin 299429 Immunoglobulin V-Type 299430 Immunoglobulin 299430 Immunoglobulin V-Type 299431 Immunoglobulin V-Type 299432 Immunoglobulin 299432 Immunoglobulin V-Type 299433 Immunoglobulin 299433 Immunoglobulin V-Type 299434 Immunoglobulin 299434 Immunoglobulin V-Type 299435 Immunoglobulin 299435 Immunoglobulin V-Type 299436 Immunoglobulin 299436 Immunoglobulin V-Type 299437 Immunoglobulin 299437 Immunoglobulin V-Type 299438 Immunoglobulin 299438 Immunoglobulin V-Type 299439 Immunoglobulin 299439 Immunoglobulin V-Type 299440 Immunoglobulin 299440 Immunoglobulin V-Type 299441 Immunoglobulin 299441 Immunoglobulin V-Type 299442 Immunoglobulin 299442 Immunoglobulin V-Type 299443 Immunoglobulin 299443 Immunoglobulin V-Type 299444 Immunoglobulin 299444 Immunoglobulin V-Type 299445 Immunoglobulin 299445 Immunoglobulin V-Type 299446 Immunoglobulin 299446 Immunoglobulin V-Type 299447 Immunoglobulin 299447 Immunoglobulin V-Type 299448 Immunoglobulin 299448 Immunoglobulin V-Type 299449 Immunoglobulin 299449 Immunoglobulin V-Type 299450 Immunoglobulin 299450 Immunoglobulin V-Type 299451 Immunoglobulin 299451 Immunoglobulin V-Type 299452 Immunoglobulin 299452 Immunoglobulin V-Type 299453 Immunoglobulin V-Type 299454 Immunoglobulin 299454 Immunoglobulin V-Type 299455 Immunoglobulin 299455 Immunoglobulin V-Type 299457 Immunoglobulin V-Type 299458 Immunoglobulin 299458 Immunoglobulin V-Type 299459 Immunoglobulin 299459 Immunoglobulin V-Type 299460 Immunoglobulin 299460 Immunoglobulin V-Type 299461 Immunoglobulin V-Type 299462 Immunoglobulin 299462 Immunoglobulin V-Type 299463 Immunoglobulin 299463 Immunoglobulin V-Type 299464 Immunoglobulin 299464 Immunoglobulin V-Type 299465 Immunoglobulin V-Type 299466 Immunoglobulin 299466 Immunoglobulin V-Type 299467 Immunoglobulin 299467 Immunoglobulin V-Type 299468 Immunoglobulin 299468 Immunoglobulin V-Type 299469 Immunoglobulin 299469 Immunoglobulin V-Type 299470 Immunoglobulin V-Type 299471 Immunoglobulin 299471 Immunoglobulin V-Type 299473 Immunoglobulin 299473 Immunoglobulin V-Type 299474 Immunoglobulin 299474 Immunoglobulin V-Type 299475 Immunoglobulin 299475 Immunoglobulin V-Type 299476 Immunoglobulin V-Type 299478 Immunoglobulin 299478 Immunoglobulin V-Type 299479 Immunoglobulin 299479 Immunoglobulin V-Type 299480 Immunoglobulin V-Type 299482 Immunoglobulin 299482 Immunoglobulin V-Type 299483 Immunoglobulin 299483 Immunoglobulin V-Type 299484 Immunoglobulin 299484 Immunoglobulin V-Type 299485 Immunoglobulin V-Type 299488 Protein kinase C conserved region 2 (CalB) 299489 Protein kinase C conserved region 2 (CalB) 299492 Guanine nucleotide exchange factor for Ras-like small GTPases 299498 Tyrosine kinase, catalytic domain 299498 Serine/Threonine protein kinases, catalytic domain 299502 Contains conserved Gly-Tyr-Phe residues 299510 Broad-Complex, Tramtrack and Bric a brac 299525 LCCL domain 299528 RNA recognition motif 299535 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 299542 Immunoglobulin V-Type 299543 Immunoglobulin V-Type 299544 Immunoglobulin 299544 Immunoglobulin V-Type 299545 Immunoglobulin V-Type 299546 Immunoglobulin 299546 Immunoglobulin V-Type 299547 Immunoglobulin V-Type 299548 Immunoglobulin 299548 Immunoglobulin V-Type 299549 Immunoglobulin V-Type 299551 Immunoglobulin 299551 Immunoglobulin V-Type 299557 PHD zinc finger 299557 krueppel associated box 299557 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 299560 krueppel associated box 299572 krueppel associated box 299587 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 299602 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 299606 Trypsin-like serine protease 299613 K homology RNA-binding domain 299615 Homeodomain 299620 U1-like zinc finger 299624 Immunoglobulin 299624 Immunoglobulin C-2 Type 299624 Leucine rich repeat N-terminal domain 299640 krueppel associated box 299642 Low-density lipoprotein receptor domain class A 299648 leucine rich region 299652 leucine rich region 299653 leucine rich region 299660 Tyrosine kinase, catalytic domain 299660 Serine/Threonine protein kinases, catalytic domain 299662 Ubiquitin associated domain 299662 Tyrosine kinase, catalytic domain 299662 Serine/Threonine protein kinases, catalytic domain 299663 Tyrosine kinase, catalytic domain 299663 Serine/Threonine protein kinases, catalytic domain 299664 Tyrosine kinase, catalytic domain 299664 Serine/Threonine protein kinases, catalytic domain 299668 Tyrosine kinase, catalytic domain 299668 Serine/Threonine protein kinases, catalytic domain 299670 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 299671 Tyrosine kinase, catalytic domain 299671 Serine/Threonine protein kinases, catalytic domain 299672 Tyrosine kinase, catalytic domain 299672 Serine/Threonine protein kinases, catalytic domain 299673 RIO-like kinase 299673 Tyrosine kinase, catalytic domain 299673 Serine/Threonine protein kinases, catalytic domain 299674 Tyrosine kinase, catalytic domain 299674 Serine/Threonine protein kinases, catalytic domain 299676 RIO-like kinase 299676 Tyrosine kinase, catalytic domain 299676 Serine/Threonine protein kinases, catalytic domain 299685 BPI/LBP/CETP C-terminal domain 299685 BPI/LBP/CETP N-terminal domain 299687 helix loop helix domain 299689 Cold shock protein domain 299690 Histone 2A 299694 Tyrosine kinase, catalytic domain 299694 Serine/Threonine protein kinases, catalytic domain 299703 high mobility group 299705 14-3-3 homologues 299706 WD40 repeats 299710 Immunoglobulin 299710 Immunoglobulin C-2 Type 299724 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 299737 Netrin C-terminal Domain 299737 Laminin N-terminal domain (domain VI) 299737 Laminin-type epidermal growth factor-like domai 299762 Tetratricopeptide repeats 299766 helix loop helix domain 299767 helix loop helix domain 299769 JAB/MPN domain 299779 domain present in translation initiation factor eIF2B and eIF5 299783 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 299784 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 299790 ARF-like small GTPases 299799 Rab subfamily of small GTPases 299799 Ras subfamily of RAS small GTPases 299799 Rho (Ras homology) subfamily of Ras-like small GTPases 299801 RNA recognition motif 299820 Dual specificity phosphatase, catalytic domain 299820 Protein tyrosine phosphatase, catalytic domain motif 299824 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 299827 Serine/Threonine protein kinases, catalytic domain 299839 Histone H3 299854 GTPase-activator protein for Rho-like GTPases 299870 zinc finger 299872 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 299878 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 299879 Fibrinogen-related domains (FReDs) 299881 Fibrinogen-related domains (FReDs) 299890 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 299891 Domain abundant in complement control proteins 299891 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 299892 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 299893 Domain abundant in complement control proteins 299894 Domain abundant in complement control proteins 299899 JAB/MPN domain 299914 Src homology 3 domains 299915 Tyrosine kinase, catalytic domain 299915 Serine/Threonine protein kinases, catalytic domain 299919 Phospholipase A2 299928 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 299929 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 299931 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 299937 RNA recognition motif 299942 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 299952 Annexin repeats 299957 Modified RING finger domain 299962 snRNP Sm proteins 299969 WD40 repeats 299970 Frizzled 299978 EF-hand, calcium binding motif 299990 Tyrosine kinase, catalytic domain 299990 Serine/Threonine protein kinases, catalytic domain 299991 Serine/Threonine protein kinases, catalytic domain 299996 von Willebrand factor (vWF) type A domain 300007 Histone H3 300009 Putative single-stranded nucleic acids-binding domain 300019 Ly-6 antigen / uPA receptor -like domain 300023 Ly-6 antigen / uPA receptor -like domain 300024 Ly-6 antigen / uPA receptor -like domain 300025 Ly-6 antigen / uPA receptor -like domain 300029 DNA Topoisomerase I (eukaryota) 300030 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 300034 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 300044 Adenylyl- / guanylyl cyclase, catalytic domain 300050 WD40 repeats 300053 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 300054 FORKHEAD 300055 ankyrin repeats 300062 Rab subfamily of small GTPases 300062 Ras subfamily of RAS small GTPases 300062 Rho (Ras homology) subfamily of Ras-like small GTPases 300062 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 300063 PB1 domain 300095 helix loop helix domain 300098 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 300115 GTPase-activator protein for Rho-like GTPases 300117 PHD zinc finger 300127 G-protein-coupled receptor proteolytic site domain 300128 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 300134 Histone H3 300144 Tyrosine kinase, catalytic domain 300144 Serine/Threonine protein kinases, catalytic domain 300147 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 300150 Kelch domain 300158 WD40 repeats 300161 Tyrosine kinase, catalytic domain 300161 Serine/Threonine protein kinases, catalytic domain 300162 high mobility group 300170 RNA recognition motif 300172 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 300177 Tyrosine kinase, catalytic domain 300177 Serine/Threonine protein kinases, catalytic domain 300178 Homeodomain 300186 Immunoglobulin 300186 Immunoglobulin 300186 Immunoglobulin C-2 Type 300197 krueppel associated box 300208 helicase superfamily c-terminal domain 300212 found in Wnt-1 300220 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 300222 Forkhead associated domain 300224 Domain with 2 conserved Trp (W) residues 300229 Domain in the RNA-binding Lupus La protein 300232 Trypsin-like serine protease 300254 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 300255 Ligand binding domain of hormone receptors 300262 Homeodomain 300263 Homeodomain 300264 Homeodomain 300266 Chromo Shadow Domain 300266 Chromatin organization modifier domain 300267 U1-like zinc finger 300268 Ring finger 300274 Ring finger 300278 S4 RNA-binding domain 300300 Ligand binding domain of hormone receptors 300305 K homology RNA-binding domain 300308 Tyrosine kinase, catalytic domain 300308 Serine/Threonine protein kinases, catalytic domain 300320 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 300324 Immunoglobulin 300329 krueppel associated box 300330 krueppel associated box 300334 RNA recognition motif 300337 Ubiquitin homologues 300338 Zinc-dependent metalloprotease 300338 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 300339 Zinc-dependent metalloprotease 300339 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 300340 Zinc-dependent metalloprotease 300340 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 300341 Zinc-dependent metalloprotease 300341 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 300344 Galectin 300350 GTPase-activator protein for Rho-like GTPases 300353 Extension to Ser/Thr-type protein kinases 300353 Serine/Threonine protein kinases, catalytic domain 300356 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 300356 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 300381 high mobility group 300386 high mobility group 300417 Protein present in Fab1, YOTB, Vac1, and EEA1 300422 K homology RNA-binding domain 300426 Chromatin organization modifier domain 300429 Eps15 homology domain 300430 FORKHEAD 300438 Calcium-binding EGF-like domain 300438 Low-density lipoprotein receptor domain class A 300438 Calcium-binding EGF-like domain 300438 Low-density lipoprotein-receptor YWTD domain 300444 Ras association (RalGDS/AF-6) domain 300444 Guanine nucleotide exchange factor for Ras-like small GTPases 300448 krueppel associated box 300455 von Willebrand factor (vWF) type C domain 300455 von Willebrand factor (vWF) type D domain 300474 ADAM Cysteine-Rich Domain 300474 Thrombospondin type 1 repeats 300475 ADAM Cysteine-Rich Domain 300475 Thrombospondin type 1 repeats 300485 Src homology 3 domains 300489 Toll - interleukin 1 - resistance 300490 Immunoglobulin 300490 Immunoglobulin C-2 Type 300511 RNA recognition motif 300517 Immunoglobulin 300518 Immunoglobulin 300518 Immunoglobulin C-2 Type 300518 Immunoglobulin 300518 Immunoglobulin C-2 Type 300519 Immunoglobulin 300519 Immunoglobulin V-Type 300519 Immunoglobulin C-2 Type 300520 Immunoglobulin 300520 Immunoglobulin V-Type 300520 Immunoglobulin C-2 Type 300521 "FY-rich" domain, C-terminal region 300521 "FY-rich" domain, N-terminal region 300543 Myosin. Large ATPases. ATPase 300593 Rab subfamily of small GTPases 300593 Ras subfamily of RAS small GTPases 300593 Rho (Ras homology) subfamily of Ras-like small GTPases 300593 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 300648 Homeodomain 300649 Immunoglobulin 300653 Zona pellucida (ZP) domain 300653 von Willebrand factor (vWF) type D domain 300655 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 300656 B-Box-type zinc finger 300657 B-Box-type zinc finger 300660 Ubiquitin associated domain 300668 Histone 2A 300678 Immunoglobulin C-2 Type 300679 Immunoglobulin 300679 Immunoglobulin V-Type 300680 Trypsin-like serine protease 300682 Scavenger receptor Cys-rich 300682 Trypsin-like serine protease 300683 Immunoglobulin 300683 Immunoglobulin C-2 Type 300685 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins 300686 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins 300689 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 300701 domain in high mobilty group proteins HMG14 and HMG 17 300710 DEAD-like helicases superfamily 300710 helicase superfamily c-terminal domain 300715 WD40 repeats 300718 Src homology 2 domains 300722 WD40 repeats 300728 RNA recognition motif 300732 Src homology 3 domains 300736 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 300737 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 300738 Protein tyrosine phosphatase, catalytic domain 300740 Ribosomal protein L11/L12 300742 Tyrosine kinase, catalytic domain 300742 Serine/Threonine protein kinases, catalytic domain 300744 Ubiquitin homologues 300745 semaphorin domain 300745 domain found in Plexins, Semaphorins and Integrins 300748 prohibitin homologues 300758 RNA recognition motif 300760 Histone H3 300770 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 300771 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 300784 Fibronectin type 3 domain 300785 Immunoglobulin 300785 Immunoglobulin C-2 Type 300789 Kelch domain 300789 Broad-Complex, Tramtrack and Bric a brac 300792 ankyrin repeats 300796 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 300799 Serine/Threonine protein kinases, catalytic domain 300807 Ligand binding domain of hormone receptors 300811 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 300812 domain present in cyclins, TFIIB and Retinoblastoma 300815 Homologues of snake disintegrins 300824 Immunoglobulin 300824 Immunoglobulin C-2 Type 300831 Protein kinase C conserved region 2 (CalB) 300831 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 300846 Somatomedin B -like domains 300861 14-3-3 homologues 300867 Ribosomal protein L11/L12 300884 Ring finger 300884 Domain in SPla and the RYanodine Receptor. 300889 ankyrin repeats 300901 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 300901 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 300902 RNA recognition motif 300913 Immunoglobulin 300913 Immunoglobulin C-2 Type 300921 Src homology 3 domains 300937 Immunoglobulin 300937 Immunoglobulin V-Type 300940 Domains in Na-Ca exchangers and integrin-beta4 300940 G-protein-coupled receptor proteolytic site domain 300940 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 300943 Phosphoinositide 3-kinase, catalytic domain 300950 Domain in SPla and the RYanodine Receptor. 300951 BCL (B-Cell lymphoma) 300954 high mobility group 300955 Src homology 3 domains 300955 Src homology 2 domains 300960 Fibronectin type 3 domain 300960 Tyrosine kinase, catalytic domain 300960 Ephrin receptor ligand binding domain 300960 Serine/Threonine protein kinases, catalytic domain 300960 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 300965 ARF-like small GTPases 300965 Sar1p-like members of the Ras-family of small GTPases 300972 Protein kinase C conserved region 2 (CalB) 300978 WD40 repeats 300992 von Willebrand factor (vWF) type A domain 300995 semaphorin domain 300996 glycine rich nucleic binding domain 300997 Actin depolymerisation factor/cofilin -like domains 300999 semaphorin domain 300999 Tyrosine kinase, catalytic domain 300999 ig-like, plexins, transcription factors 300999 domain found in Plexins, Semaphorins and Integrins 300999 Serine/Threonine protein kinases, catalytic domain 301008 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 301016 Kazal type serine protease inhibitors 301025 Protein tyrosine phosphatase, catalytic domain 301025 Protein tyrosine phosphatase, catalytic domain motif 301026 Cystatin-like domain 301027 Trypsin-like serine protease 301028 Trypsin-like serine protease 301039 Link (Hyaluronan-binding) 301042 B-Box-type zinc finger 301042 B-Box C-terminal domain 301042 Filamin-type immunoglobulin domains 301053 RNA recognition motif 301056 catalytic domain of ctd-like phosphatases 301059 Toll - interleukin 1 - resistance 301059 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 301060 Tyrosine kinase, catalytic domain 301060 Serine/Threonine protein kinases, catalytic domain 301061 DNA/RNA non-specific endonuclease 301062 DNA/RNA non-specific endonuclease 301076 leucine rich region 301076 krueppel associated box 301085 Protein present in Fab1, YOTB, Vac1, and EEA1 301092 Chromatin organization modifier domain 301096 Low-density lipoprotein-receptor YWTD domain 301096 Low-density lipoprotein receptor domain class A 301097 Vault protein Inter-alpha-Trypsin domain 301106 Fibronectin type 3 domain 301125 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 301127 Ring finger 301128 Tudor domain 301132 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 301133 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 301135 high mobility group 301143 K homology RNA-binding domain 301149 krueppel associated box 301149 G-protein-coupled receptor proteolytic site domain 301154 Tyrosine kinase, catalytic domain 301154 Serine/Threonine protein kinases, catalytic domain 301158 RNA recognition motif 301164 bromo domain 301165 Tyrosine kinase, catalytic domain 301165 Serine/Threonine protein kinases, catalytic domain 301166 Tyrosine kinase, catalytic domain 301166 Serine/Threonine protein kinases, catalytic domain 301170 Actin depolymerisation factor/cofilin -like domains 301175 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 301218 RNA recognition motif 301225 Domain present in ZO-1 and Unc5-like netrin receptors 301225 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 301241 Tyrosine kinase, catalytic domain 301241 Serine/Threonine protein kinases, catalytic domain 301244 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 301246 RNA polymerases D 301252 Histidine kinase-like ATPases 301269 G-protein-coupled receptor proteolytic site domain 301282 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 301295 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases 301296 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 301312 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 301319 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 301319 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 301322 Zinc finger domain 301324 Actin depolymerisation factor/cofilin -like domains 301325 BAG domains, present in regulator of Hsp70 proteins 301328 Calponin homology domain 301329 Calponin homology domain 301333 Protein tyrosine phosphatase, catalytic domain 301333 Protein tyrosine phosphatase, catalytic domain motif 301336 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 301337 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 301339 snRNP Sm proteins 301346 Immunoglobulin 301346 semaphorin domain 301346 domain found in Plexins, Semaphorins and Integrins 301348 Tyrosine kinase, catalytic domain 301360 Ring finger 301361 Ring finger 301363 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 301364 Histone H3 301365 Toll - interleukin 1 - resistance 301366 Toll - interleukin 1 - resistance 301373 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 301379 DnaJ molecular chaperone homology domain 301390 Ubiquitin homologues 301392 Ribosomal protein L11/L12 301393 Kazal type serine protease inhibitors 301400 RNA recognition motif 301404 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 301415 ankyrin repeats 301426 Tyrosine kinase, catalytic domain 301426 Serine/Threonine protein kinases, catalytic domain 301429 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 301433 Tyrosine kinase, catalytic domain 301433 Serine/Threonine protein kinases, catalytic domain 301434 Serine/Threonine protein kinases, catalytic domain 301436 Broad-Complex, Tramtrack and Bric a brac 301439 Tyrosine kinase, catalytic domain 301439 Serine/Threonine protein kinases, catalytic domain 301440 Frizzled 301442 Ubiquitin homologues 301445 WD40 repeats 301448 Src homology 3 domains 301455 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 301461 ADAM Cysteine-Rich Domain 301461 Homologues of snake disintegrins 301468 Beta/gamma crystallins 301469 Beta/gamma crystallins 301471 RNA recognition motif 301472 Beta/gamma crystallins 301485 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 301488 helicase superfamily c-terminal domain 301489 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 301492 Ubiquitin homologues 301499 Ubiquitin homologues 301501 Ubiquitin homologues 301509 Protein tyrosine phosphatase, catalytic domain motif 301510 domain involved in Ras-like GTPase signaling 301510 Protein present in Fab1, YOTB, Vac1, and EEA1 301512 WD40 repeats 301518 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 301520 Beta/gamma crystallins 301526 DnaJ molecular chaperone homology domain 301527 Protein tyrosine phosphatase, catalytic domain 301527 Protein tyrosine phosphatase, catalytic domain motif 301528 RNA recognition motif 301531 Immunoglobulin 301531 Immunoglobulin C-2 Type 301532 Serine/Threonine protein kinases, catalytic domain 301534 Immunoglobulin 301534 Immunoglobulin C-2 Type 301539 Actin depolymerisation factor/cofilin -like domains 301549 WD40 repeats 301549 Protein present in Fab1, YOTB, Vac1, and EEA1 301568 Domain Homologous to E6-AP Carboxyl Terminus with 301570 SAND domain 301571 SAND domain 301584 Alkaline phosphatase homologues 301585 Alkaline phosphatase homologues 301586 Alkaline phosphatase homologues 301587 Alkaline phosphatase homologues 301591 Diacylglycerol kinase catalytic domain (presumed) 301607 14-3-3 homologues 301608 Ubiquitin homologues 301616 Calcium-binding EGF-like domain 301616 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 301619 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 301626 Immunoglobulin 301626 Immunoglobulin V-Type 301627 Immunoglobulin 301627 Immunoglobulin V-Type 301631 krueppel associated box 301645 Histone H3 301649 Laminin G domain 301650 Laminin G domain 301650 Coagulation factor 5/8 C-terminal domain, discoidin domain 301653 DnaJ molecular chaperone homology domain 301658 Tyrosine kinase, catalytic domain 301658 Serine/Threonine protein kinases, catalytic domain 301664 ankyrin repeats 301665 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 301666 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 301670 Src homology 2 domains 301670 suppressors of cytokine signalling 301671 Src homology 2 domains 301671 suppressors of cytokine signalling 301673 ATPase domain of DNA mismatch repair MUTS family 301674 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 301674 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 301683 RNA recognition motif 301684 Laminin G domain 301687 krueppel associated box 301693 krueppel associated box 301694 krueppel associated box 301706 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 301707 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 301709 GTPase-activator protein for Rho-like GTPases 301713 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 301715 Immunoglobulin 301715 Fibronectin type 3 domain 301715 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 301720 Tyrosine kinase, catalytic domain 301720 Serine/Threonine protein kinases, catalytic domain 301721 DEAD-like helicases superfamily 301724 Tyrosine kinase, catalytic domain 301724 Serine/Threonine protein kinases, catalytic domain 301726 Ubiquitin associated domain 301726 Tyrosine kinase, catalytic domain 301726 Serine/Threonine protein kinases, catalytic domain 301728 ankyrin repeats 301737 Tyrosine kinase, catalytic domain 301737 Serine/Threonine protein kinases, catalytic domain 301759 high mobility group 301767 krueppel associated box 301785 WD40 repeats 301792 ARF-like small GTPases 301792 Rab subfamily of small GTPases 301792 Ras subfamily of RAS small GTPases 301792 Rho (Ras homology) subfamily of Ras-like small GTPases 301792 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 301797 Ubiquitin homologues 301799 Ubiquitin homologues 301861 Actin 301897 Tyrosine kinase, catalytic domain 301897 Serine/Threonine protein kinases, catalytic domain 301898 Tyrosine kinase, catalytic domain 301898 Serine/Threonine protein kinases, catalytic domain 301899 Tyrosine kinase, catalytic domain 301899 Serine/Threonine protein kinases, catalytic domain 301900 Tyrosine kinase, catalytic domain 301900 Serine/Threonine protein kinases, catalytic domain 301901 Tyrosine kinase, catalytic domain 301901 Serine/Threonine protein kinases, catalytic domain 301910 WD40 repeats 301911 ARF-like small GTPases 301911 Rab subfamily of small GTPases 301911 Ras subfamily of RAS small GTPases 301911 Rho (Ras homology) subfamily of Ras-like small GTPases 301911 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 301957 EF-hand, calcium binding motif 301971 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 302024 GTPase-activator protein for Rho-like GTPases 302048 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 302059 Serine/Threonine protein kinases, catalytic domain 302060 Serine/Threonine protein kinases, catalytic domain 302061 RIO-like kinase 302061 Tyrosine kinase, catalytic domain 302061 Serine/Threonine protein kinases, catalytic domain 302062 Tyrosine kinase, catalytic domain 302062 Serine/Threonine protein kinases, catalytic domain 302063 RIO-like kinase 302063 Tyrosine kinase, catalytic domain 302063 Serine/Threonine protein kinases, catalytic domain 302064 RIO-like kinase 302064 Tyrosine kinase, catalytic domain 302064 Serine/Threonine protein kinases, catalytic domain 302066 RIO-like kinase 302066 Tyrosine kinase, catalytic domain 302066 Serine/Threonine protein kinases, catalytic domain 302070 Tyrosine kinase, catalytic domain 302070 Serine/Threonine protein kinases, catalytic domain 302071 Tyrosine kinase, catalytic domain 302071 Serine/Threonine protein kinases, catalytic domain 302072 Tyrosine kinase, catalytic domain 302072 Serine/Threonine protein kinases, catalytic domain 302073 Tyrosine kinase, catalytic domain 302073 Serine/Threonine protein kinases, catalytic domain 302074 Tyrosine kinase, catalytic domain 302074 Serine/Threonine protein kinases, catalytic domain 302075 Tyrosine kinase, catalytic domain 302075 Serine/Threonine protein kinases, catalytic domain 302076 Tyrosine kinase, catalytic domain 302076 Serine/Threonine protein kinases, catalytic domain 302089 Myosin. Large ATPases. ATPase 302105 RNA recognition motif 302105 DnaJ molecular chaperone homology domain 302107 RNA recognition motif 302107 DnaJ molecular chaperone homology domain 302108 Modified RING finger domain 302113 DnaJ molecular chaperone homology domain 302114 DnaJ molecular chaperone homology domain 302118 DnaJ molecular chaperone homology domain 302119 DnaJ molecular chaperone homology domain 302121 DnaJ molecular chaperone homology domain 302123 DnaJ molecular chaperone homology domain 302125 DnaJ molecular chaperone homology domain 302129 DnaJ molecular chaperone homology domain 302132 DnaJ molecular chaperone homology domain 302133 Middle domain of eukaryotic initiation factor 4G (eIF4G) 302166 krueppel associated box 302170 ankyrin repeats 302179 ARF-like small GTPases 302179 Rab subfamily of small GTPases 302179 Ras subfamily of RAS small GTPases 302179 Rho (Ras homology) subfamily of Ras-like small GTPases 302179 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 302183 Ubiquitin homologues 302213 RNA recognition motif 302224 ARF-like small GTPases 302224 Rab subfamily of small GTPases 302224 Ras subfamily of RAS small GTPases 302224 Rho (Ras homology) subfamily of Ras-like small GTPases 302224 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 302249 Ricin-type beta-trefoil 302259 Tyrosine kinase, catalytic domain 302259 Serine/Threonine protein kinases, catalytic domain 302260 Tyrosine kinase, catalytic domain 302260 Serine/Threonine protein kinases, catalytic domain 302261 Tyrosine kinase, catalytic domain 302261 Serine/Threonine protein kinases, catalytic domain 302262 Tyrosine kinase, catalytic domain 302262 Serine/Threonine protein kinases, catalytic domain 302263 Tyrosine kinase, catalytic domain 302263 Serine/Threonine protein kinases, catalytic domain 302272 Immunoglobulin 302272 Immunoglobulin V-Type 302273 Immunoglobulin 302273 Immunoglobulin V-Type 302274 Immunoglobulin 302274 Immunoglobulin V-Type 302275 Immunoglobulin 302275 Immunoglobulin V-Type 302276 Immunoglobulin 302276 Immunoglobulin V-Type 302277 Immunoglobulin 302277 Immunoglobulin V-Type 302282 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 302288 ankyrin repeats 302291 ARF-like small GTPases 302293 ARF-like small GTPases 302296 Galectin 302310 Protein tyrosine phosphatase, catalytic domain 302310 Dual specificity phosphatase, catalytic domain 302317 high mobility group 302321 high mobility group 302324 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 302329 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 302352 Homeodomain 302365 Helical region found in SNAREs 302366 Ring finger 302369 Domain first found in the mice T locus (Brachyury) protein 302371 prohibitin homologues 302381 Galectin 302382 RNA recognition motif 302389 high mobility group 302395 ATPases associated with a variety of cellular activities 302400 Homeodomain 302405 RNA recognition motif 302415 FORKHEAD 302422 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 302454 GTPase-activator protein for Rho-like GTPases 302456 GTPase-activator protein for Rho-like GTPases 302462 GTPase-activator protein for Rho-like GTPases 302465 krueppel associated box 302466 krueppel associated box 302467 krueppel associated box 302468 krueppel associated box 302469 krueppel associated box 302473 Leucine rich repeat C-terminal domain 302477 Chromatin organization modifier domain 302478 krueppel associated box 302495 Rab subfamily of small GTPases 302495 Ras subfamily of RAS small GTPases 302495 Rho (Ras homology) subfamily of Ras-like small GTPases 302495 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 302500 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 302502 Cullin 302516 Leucine rich repeat C-terminal domain 302538 Protein kinase C conserved region 2 (CalB) 302538 Histone 2A 302549 Rab subfamily of small GTPases 302549 Ras subfamily of RAS small GTPases 302549 Rho (Ras homology) subfamily of Ras-like small GTPases 302550 Tyrosine kinase, catalytic domain 302550 Serine/Threonine protein kinases, catalytic domain 302552 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 302553 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 302555 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 302556 Rab subfamily of small GTPases 302556 Ras subfamily of RAS small GTPases 302556 Rho (Ras homology) subfamily of Ras-like small GTPases 302557 Domain with 2 conserved Trp (W) residues 302567 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 302571 RNA recognition motif 302572 Histone H3 302574 Double-stranded RNA binding motif 302574 domain in DSRM or ZnF_C2H2 domain containing proteins 302575 Broad-Complex, Tramtrack and Bric a brac 302576 Broad-Complex, Tramtrack and Bric a brac 302578 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 302583 FORKHEAD 302585 BCL (B-Cell lymphoma) 302588 Chromatin organization modifier domain 302590 Rab subfamily of small GTPases 302590 Ras subfamily of RAS small GTPases 302592 krueppel associated box 302598 Immunoglobulin 302599 Zinc finger domain 302600 Vault protein Inter-alpha-Trypsin domain 302601 Rab subfamily of small GTPases 302601 Ras subfamily of RAS small GTPases 302601 Rho (Ras homology) subfamily of Ras-like small GTPases 302605 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 302609 Modified RING finger domain 302611 Domain Homologous to E6-AP Carboxyl Terminus with 302614 Phosphoinositide 3-kinase, catalytic domain 302632 GTPase-activator protein for Rho-like GTPases 302639 Ring finger 302653 Histone H3 302655 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 302656 Band 4.1 homologues 302658 Cold shock protein domain 302659 Toll - interleukin 1 - resistance 302659 Leucine rich repeat C-terminal domain 302667 Bruton's tyrosine kinase Cys-rich motif 302667 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 302670 RRM_1 domain 302670 RNA recognition motif 302674 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 302675 RNA recognition motif 302688 prohibitin homologues 302694 Ubiquitin homologues 302695 Ubiquitin homologues 302697 eukaryotic translation initiation factor 1A 302702 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 302703 Broad-Complex, Tramtrack and Bric a brac 302711 WD40 repeats 302716 K homology RNA-binding domain 302729 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 302737 Spectrin repeats 302738 Spectrin repeats 302740 Spectrin repeats 302742 high mobility group 302751 Immunoglobulin 302751 Immunoglobulin C-2 Type 302761 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 302762 WD40 repeats 302765 Guanine nucleotide exchange factor for Ras-like GTPases 302768 RNA recognition motif 302771 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 302772 K homology RNA-binding domain 302773 K homology RNA-binding domain 302774 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 302775 Ring finger 302776 K homology RNA-binding domain 302780 RNA recognition motif 302783 Histone 2A 302787 domain present in translation initiation factor eIF2B and eIF5 302788 high mobility group 302798 high mobility group 302799 high mobility group 302801 high mobility group 302804 Broad-Complex, Tramtrack and Bric a brac 302807 Armadillo/beta-catenin-like repeats 302811 erythroblast transformation specific domain 302816 RNA recognition motif 302817 RNA recognition motif 302819 GTPase-activator protein for Rho-like GTPases 302826 Band 4.1 homologues 302840 high mobility group 302842 Calcium-binding EGF-like domain 302842 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 302843 Histone H3 302855 RRM_1 domain 302855 RNA recognition motif 302856 Src homology 3 domains 302856 Calponin homology domain 302858 Histone H3 302867 Protein tyrosine phosphatase, catalytic domain 302867 Dual specificity phosphatase, catalytic domain 302873 Ring finger 302876 GTPase-activator protein for Rho-like GTPases 302879 RNA recognition motif 302879 RNA recognition motif 302880 WD40 repeats 302893 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 302920 RRM_1 domain 302920 RNA recognition motif 302931 RNA recognition motif 302931 domain in splicing factors 302937 ankyrin repeats 302937 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 302944 DnaJ molecular chaperone homology domain 302945 Leucine rich repeat N-terminal domain 302950 Adenylyl- / guanylyl cyclase, catalytic domain 302953 Broad-Complex, Tramtrack and Bric a brac 302962 leucine rich region 302963 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 302970 Trypsin-like serine protease 302971 Trypsin-like serine protease 302976 Src homology 3 domains 302981 Domain in SPla and the RYanodine Receptor. 302988 Protein kinase C conserved region 2 (CalB) 302989 Trypsin-like serine protease 302990 Trypsin-like serine protease 302990 Trypsin-like serine protease 302993 high mobility group 303003 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 303010 RNA recognition motif 303019 domain in neuralized proteins 303021 Src homology 3 domains 303021 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 303024 WD40 repeats 303024 A Receptor for Ubiquitination Targets 303039 Domain with 2 conserved Trp (W) residues 303049 high mobility group 303058 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 303059 domain present in cyclins, TFIIB and Retinoblastoma 303060 domain with conserved PWWP motif 303068 high mobility group 303072 Fibronectin type 3 domain 303075 Immunoglobulin 303083 GTPase-activator protein for Rho-like GTPases 303085 GTPase-activator protein for Rho-like GTPases 303086 GTPase-activator protein for Rho-like GTPases 303088 B-Box-type zinc finger 303088 associated with SPRY domains 303088 Domain in SPla and the RYanodine Receptor. 303089 Ring finger 303089 B-Box-type zinc finger 303089 Modified RING finger domain 303089 associated with SPRY domains 303089 Domain in SPla and the RYanodine Receptor. 303091 RNA recognition motif 303107 krueppel associated box 303110 C-terminal to LisH motif. 303111 C-terminal to LisH motif. 303113 PHD zinc finger 303129 Kazal type serine protease inhibitors 303130 Immunoglobulin 303130 Immunoglobulin C-2 Type 303141 Ras association (RalGDS/AF-6) domain 303141 Cyclic nucleotide-monophosphate binding domain 303141 Guanine nucleotide exchange factor for Ras-like GTPases 303141 Guanine nucleotide exchange factor for Ras-like small GTPases 303141 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 303147 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 303158 Domain in the RNA-binding Lupus La protein 303158 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 303160 WD40 repeats 303167 Ring finger 303167 B-Box-type zinc finger 303167 associated with SPRY domains 303167 Domain in SPla and the RYanodine Receptor. 303170 Actin depolymerisation factor/cofilin -like domains 303171 krueppel associated box 303172 krueppel associated box 303173 krueppel associated box 303174 Immunoglobulin 303174 Immunoglobulin V-Type 303175 Histone H2B 303176 Histone H2B 303177 Histone 2A 303178 Ring finger 303178 B-Box-type zinc finger 303178 Domain in SPla and the RYanodine Receptor. 303179 Connexin homologues 303181 found in Wnt-1 303182 found in Wnt-1 303191 Myosin. Large ATPases. ATPase 303202 Rab subfamily of small GTPases 303202 Ras subfamily of RAS small GTPases 303202 Rho (Ras homology) subfamily of Ras-like small GTPases 303202 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 303206 Tyrosine kinase, catalytic domain 303206 Serine/Threonine protein kinases, catalytic domain 303209 Calponin homology domain 303212 leucine rich region 303212 krueppel associated box 303213 krueppel associated box 303214 B-Box-type zinc finger 303214 associated with SPRY domains 303214 Domain in SPla and the RYanodine Receptor. 303215 WD40 repeats 303222 BAR domain 303222 GTPase-activator protein for Rho-like GTPases 303226 zinc finger 303226 leucine rich region 303226 krueppel associated box 303241 PHD zinc finger 303241 DEAD-like helicases superfamily 303241 Chromatin organization modifier domain 303241 helicase superfamily c-terminal domain 303244 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. Function unknown, but likely to be associated with the glycosylation machinery 303247 Tyrosine kinase, catalytic domain 303247 Serine/Threonine protein kinases, catalytic domain 303248 domain in neuralized proteins 303252 Lipoxygenase homology 2 (beta barrel) domain 303260 Putative single-stranded nucleic acids-binding domain 303274 PHD zinc finger 303285 meprin and TRAF homology 303285 Modified RING finger domain 303289 Calponin homology domain 303294 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 303304 domain involved in Ras-like GTPase signaling 303304 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 303309 Large family of predicted nucleotide-binding domains 303310 zinc finger 303312 WD40 repeats 303317 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 303321 domain present in cyclins, TFIIB and Retinoblastoma 303322 domain present in cyclins, TFIIB and Retinoblastoma 303326 Serine/Threonine protein kinases, catalytic domain 303327 Serine/Threonine protein kinases, catalytic domain 303328 Tyrosine kinase, catalytic domain 303328 Serine/Threonine protein kinases, catalytic domain 303329 Tyrosine kinase, catalytic domain 303329 Serine/Threonine protein kinases, catalytic domain 303336 WD40 repeats 303336 suppressors of cytokine signalling 303342 Dual specificity phosphatase, catalytic domain 303347 helix loop helix domain 303349 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 303350 Ring finger 303350 Domain in SPla and the RYanodine Receptor. 303353 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 303369 U1-like zinc finger 303371 Fibronectin type 3 domain 303372 WD40 repeats 303376 Fibronectin type 3 domain 303382 Rab subfamily of small GTPases 303382 Ras subfamily of RAS small GTPases 303382 Rho (Ras homology) subfamily of Ras-like small GTPases 303384 Zinc-dependent metalloprotease 303384 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 303388 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 303391 Myosin. Large ATPases. ATPase 303394 Domain in ubiquitin-specific proteases 303398 Domain first found in the mice T locus (Brachyury) protein 303399 Domain first found in the mice T locus (Brachyury) protein 303402 helicase superfamily c-terminal domain 303403 DEAD-like helicases superfamily 303403 helicase superfamily c-terminal domain 303419 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 303454 RNA recognition motif 303469 Homeodomain 303476 Src homology 3 domains 303477 RNA recognition motif 303477 K homology RNA-binding domain 303477 RNA recognition motif 303477 K homology RNA-binding domain 303478 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 303480 Homeodomain 303484 Homeodomain 303485 Homeodomain 303486 Homeodomain 303488 Homeodomain 303489 Homeodomain 303490 Homeodomain 303491 Homeodomain 303493 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 303494 Chromo Shadow Domain 303494 Chromatin organization modifier domain 303496 Domain first found in the mice T locus (Brachyury) protein 303497 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 303500 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 303501 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 303505 domain found in Plexins, Semaphorins and Integrins 303505 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 303506 G protein alpha subunit 303506 ARF-like small GTPases 303506 Rab subfamily of small GTPases 303506 Ras subfamily of RAS small GTPases 303506 Sar1p-like members of the Ras-family of small GTPases 303506 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 303508 Leucine-rich repeat - CC (cysteine-containing) subfamily 303516 Insulin growth factor-binding protein homologues 303516 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 303533 Kelch domain 303533 Broad-Complex, Tramtrack and Bric a brac 303535 DnaJ molecular chaperone homology domain 303536 Tetratricopeptide repeats 303538 DEAD-like helicases superfamily 303538 helicase superfamily c-terminal domain 303540 bromo domain 303541 DEAD-like helicases superfamily 303541 helicase superfamily c-terminal domain 303552 domain involved in Ras-like GTPase signaling 303553 Rab subfamily of small GTPases 303553 Rho (Ras homology) subfamily of Ras-like small GTPases 303553 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 303554 PB1 domain 303554 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 303557 RNA recognition motif 303559 G protein alpha subunit 303559 ARF-like small GTPases 303559 Rab subfamily of small GTPases 303559 Ras subfamily of RAS small GTPases 303559 Sar1p-like members of the Ras-family of small GTPases 303559 Rho (Ras homology) subfamily of Ras-like small GTPases 303561 Src homology 3 domains 303561 domain in receptor targeting proteins Lin-2 and Lin-7 303561 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 303562 Immunoglobulin 303565 Acid phosphatase homologues 303565 Acid phosphatase homologues 303567 Ubiquitin homologues 303569 domain involved in Ras-like GTPase signaling 303571 glycine rich nucleic binding domain 303575 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 303583 Domain with 2 conserved Trp (W) residues 303583 GTPase-activator protein for Rho-like GTPases 303583 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 303584 Src homology 3 domains 303584 domain involved in Ras-like GTPase signaling 303584 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 303584 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 303586 found in Wnt-1 303600 ankyrin repeats 303601 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 303604 PB1 domain 303604 Tyrosine kinase, catalytic domain 303604 Serine/Threonine protein kinases, catalytic domain 303605 Serine/Threonine protein kinases, catalytic domain 303605 Tyrosine kinase, catalytic domain 303605 Serine/Threonine protein kinases, catalytic domain 303605 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 303607 DEAD-like helicases superfamily 303607 helicase superfamily c-terminal domain 303614 Domain Homologous to E6-AP Carboxyl Terminus with 303615 Domain with 2 conserved Trp (W) residues 303615 Protein kinase C conserved region 2 (CalB) 303623 Extension to Ser/Thr-type protein kinases 303623 Serine/Threonine protein kinases, catalytic domain 303624 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 303634 ARF-like small GTPases 303634 G protein alpha subunit 303634 Sar1p-like members of the Ras-family of small GTPases 303659 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 303660 Broad-Complex, Tramtrack and Bric a brac 303663 Immunoglobulin 303663 Immunoglobulin V-Type 303665 Immunoglobulin 303665 Immunoglobulin V-Type 303665 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 303666 Immunoglobulin 303666 Immunoglobulin V-Type 303668 ARF-like small GTPases 303668 Rab subfamily of small GTPases 303668 Ras subfamily of RAS small GTPases 303668 Rho (Ras homology) subfamily of Ras-like small GTPases 303668 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 303676 Middle domain of eukaryotic initiation factor 4G (eIF4G) 303678 ankyrin repeats 303678 Src homology 3 domains 303678 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 303683 Ring finger 303683 B-Box-type zinc finger 303683 associated with SPRY domains 303683 Domain in SPla and the RYanodine Receptor. 303684 Ring finger 303684 Domain in SPla and the RYanodine Receptor. 303687 Plectin repeat 303687 Spectrin repeats 303689 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 303694 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 303701 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 303703 Myosin. Large ATPases. ATPase 303708 Myosin. Large ATPases. ATPase 303711 Myosin. Large ATPases. ATPase 303713 Myosin. Large ATPases. ATPase 303717 Myosin. Large ATPases. ATPase 303723 Myosin. Large ATPases. ATPase 303728 Myosin. Large ATPases. ATPase 303730 Chromatin organization modifier domain 303731 Chromatin organization modifier domain 303732 Chromatin organization modifier domain 303734 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 303735 ATPases associated with a variety of cellular activities 303736 Ring finger 303738 RNA polymerase subunit 8 303741 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 303747 Immunoglobulin 303749 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 303753 FORKHEAD 303754 ARF-like small GTPases 303754 Rab subfamily of small GTPases 303754 Ras subfamily of RAS small GTPases 303754 suppressors of cytokine signalling 303754 Rho (Ras homology) subfamily of Ras-like small GTPases 303754 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 303760 Src homology 2 domains 303762 krueppel associated box 303768 Eps15 homology domain 303770 Ubiquitin homologues 303773 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 303781 Immunoglobulin C-Type 303782 Immunoglobulin 303782 Immunoglobulin C-Type 303782 Immunoglobulin V-Type 303785 Src homology 3 domains 303785 Fibronectin type 3 domain 303792 Kelch domain 303793 krueppel associated box 303798 Armadillo/beta-catenin-like repeats 303811 Domain present in Dishevelled and axin 303811 Domain found in Dishevelled, Egl-10, and Pleckstrin 303811 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 303814 von Willebrand factor (vWF) type C domain 303814 Domain in SOG (short gastrulation protein) and chordin 303815 Ribosomal protein L11/L12 303823 Tyrosine kinase, catalytic domain 303823 Serine/Threonine protein kinases, catalytic domain 303824 K homology RNA-binding domain 303828 erythroblast transformation specific domain 303829 domain in high mobilty group proteins HMG14 and HMG 17 303830 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 303831 DEAD-like helicases superfamily 303831 helicase superfamily c-terminal domain 303834 catalytic domain of ctd-like phosphatases 303836 Broad-Complex, Tramtrack and Bric a brac 303861 Leucine rich repeat C-terminal domain 303861 Leucine rich repeat N-terminal domain 303876 WD40 repeats 303877 Ring finger 303878 UAS domain 303878 Domain present in ubiquitin-regulatory proteins 303882 Ubiquitin associated domain 303885 domain involved in Ras-like GTPase signaling 303887 von Willebrand factor (vWF) type D domain 303887 Adhesion-associated domain present in MUC4 and other proteins 303887 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 303888 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 303891 Calcium-binding EGF-like domain 303891 Epidermal growth factor-like domain 303892 Integrin beta subunits (N-terminal portion of extracellular region) 303904 Ring finger 303905 Appr-1"-p processing enzyme 303907 WD40 repeats 303908 Ran-binding domain 303909 Cystatin-like domain 303911 Cystatin-like domain 303912 Cystatin-like domain 303915 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 303916 DEAD-like helicases superfamily 303918 Transcription initiation factor IIE 303919 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 303926 Immunoglobulin 303926 Immunoglobulin C-2 Type 303951 Immunoglobulin 303951 Immunoglobulin V-Type 303955 Phospholipase C, catalytic domain (part) 303956 RNA recognition motif 303959 Histone H3 303963 Ring finger 303965 Myosin. Large ATPases. ATPase 303972 high mobility group 303990 Homeodomain 303991 Homeodomain 303993 RNA recognition motif 304000 Immunoglobulin 304010 Broad-Complex, Tramtrack and Bric a brac 304013 Fibronectin type 3 domain 304014 G-protein-coupled receptor proteolytic site domain 304015 Ubiquitin homologues 304017 Tetratricopeptide repeats 304021 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 304028 Tyrosine kinase, catalytic domain 304028 Serine/Threonine protein kinases, catalytic domain 304038 Helical region found in SNAREs 304039 ARF-like small GTPases 304039 Rab subfamily of small GTPases 304039 Sar1p-like members of the Ras-family of small GTPases 304041 krueppel associated box 304042 krueppel associated box 304044 krueppel associated box 304045 krueppel associated box 304046 krueppel associated box 304047 krueppel associated box 304048 krueppel associated box 304053 ankyrin repeats 304053 Tyrosine kinase, catalytic domain 304053 Serine/Threonine protein kinases, catalytic domain 304056 Broad-Complex, Tramtrack and Bric a brac 304061 WD40 repeats 304071 PAS domain 304071 helix loop helix domain 304071 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) 304084 Protein kinase C conserved region 2 (CalB) 304084 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 304088 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 304089 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 304092 Double-stranded RNA binding motif 304092 glycine rich nucleic binding domain 304093 DnaJ molecular chaperone homology domain 304103 helix loop helix domain 304109 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 304127 basic region leucin zipper 304127 Broad-Complex, Tramtrack and Bric a brac 304132 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 304135 Thrombospondin type 1 repeats 304143 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 304173 putative band 4.1 homologues' binding motif 304181 Tyrosine kinase, catalytic domain 304181 Serine/Threonine protein kinases, catalytic domain 304182 krueppel associated box 304183 Kelch domain 304191 helix loop helix domain 304193 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 304195 LGN motif, putative GEFs specific for G-alpha GTPases 304196 Ran-binding domain 304197 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 304199 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 304200 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 304201 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 304205 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 304208 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 304211 Chromatin organization modifier domain 304212 Chromatin organization modifier domain 304215 GTPase-activator protein for Rho-like GTPases 304215 in StAR and phosphatidylcholine transfer protein 304215 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 304231 krueppel associated box 304232 krueppel associated box 304234 Chromatin organization modifier domain 304239 GTPase-activator protein for Rho-like GTPases 304242 krueppel associated box 304244 Chromatin organization modifier domain 304249 Low-density lipoprotein receptor domain class A 304252 WD40 repeats 304265 Tyrosine kinase, catalytic domain 304265 Serine/Threonine protein kinases, catalytic domain 304268 Rab subfamily of small GTPases 304268 Ras subfamily of RAS small GTPases 304268 Rho (Ras homology) subfamily of Ras-like small GTPases 304270 Serine/Threonine protein kinases, catalytic domain 304271 Ring finger 304273 zinc finger 304275 leucine rich region 304277 zinc finger 304280 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 304285 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 304285 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 304285 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 304290 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 304293 krueppel associated box 304297 Fibronectin type 3 domain 304299 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 304301 Ras association (RalGDS/AF-6) domain 304305 Immunoglobulin 304305 Immunoglobulin C-2 Type 304312 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 304314 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 304333 Cyclic nucleotide-monophosphate binding domain 304336 krueppel associated box 304337 krueppel associated box 304340 krueppel associated box 304341 leucine rich region 304341 krueppel associated box 304342 leucine rich region 304343 JAB/MPN domain 304368 domain with conserved PWWP motif 304369 domain with conserved PWWP motif 304370 Rab subfamily of small GTPases 304370 Ras subfamily of RAS small GTPases 304371 Rab subfamily of small GTPases 304371 Ras subfamily of RAS small GTPases 304371 Rho (Ras homology) subfamily of Ras-like small GTPases 304371 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 304372 Putative GTP-ase activating proteins for the small GTPase, ARF 304373 A Receptor for Ubiquitination Targets 304374 A Receptor for Ubiquitination Targets 304375 Putative GTP-ase activating proteins for the small GTPase, ARF 304378 Contains conserved Gly-Tyr-Phe residues 304379 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 304380 Rab subfamily of small GTPases 304380 Ras subfamily of RAS small GTPases 304380 Rho (Ras homology) subfamily of Ras-like small GTPases 304380 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 304396 WD40 repeats 304399 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 304401 Scavenger receptor Cys-rich 304402 Dual specificity phosphatase, catalytic domain 304403 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 304435 Pentraxin / C-reactive protein / pentaxin family 304468 DEAD-like helicases superfamily 304468 helicase superfamily c-terminal domain 304479 helix loop helix domain 304488 Sigma factor PP2C-like phosphatases 304488 Serine/threonine phosphatases, family 2C, catalytic domain 304497 RNA recognition motif 304497 Cysteine-rich motif following a subset of SET domains 304497 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 304503 Domain Homologous to E6-AP Carboxyl Terminus with 304512 RNA recognition motif 304514 Domain first found in the mice T locus (Brachyury) protein 304521 Ring finger 304524 Tyrosine kinase, catalytic domain 304524 Serine/Threonine protein kinases, catalytic domain 304525 Tyrosine kinase, catalytic domain 304525 Serine/Threonine protein kinases, catalytic domain 304528 ATPases associated with a variety of cellular activities 304529 Immunoglobulin 304529 Immunoglobulin C-2 Type 304531 Immunoglobulin 304531 Immunoglobulin C-2 Type 304532 Tyrosine kinase, catalytic domain 304532 Serine/Threonine protein kinases, catalytic domain 304545 Ubiquitin homologues 304546 Putative GTP-ase activating proteins for the small GTPase, ARF 304546 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins 304550 Ubiquitin homologues 304554 Domain abundant in complement control proteins 304554 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 304560 Tetratricopeptide repeats 304569 helicase superfamily c-terminal domain 304570 DEAD-like helicases superfamily 304570 helicase superfamily c-terminal domain 304571 Ricin-type beta-trefoil 304573 DNA polymerase type-B family 304574 krueppel associated box 304575 Phospholipase C, catalytic domain (part) 304576 krueppel associated box 304576 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 304580 Dual specificity phosphatase, catalytic domain 304582 RNA recognition motif 304591 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 304601 bromo domain 304601 PHD zinc finger 304601 Methyl-CpG binding domain 304601 domain in different transcription and chromosome remodeling factors 304605 zinc finger 304605 Ubiquitin homologues 304608 Zinc-dependent metalloprotease 304608 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 304615 krueppel associated box 304617 krueppel associated box 304618 Helical region found in SNAREs 304620 krueppel associated box 304624 RNA recognition motif 304625 Helical region found in SNAREs 304626 krueppel associated box 304627 krueppel associated box 304628 krueppel associated box 304639 Ribosomal protein S1-like RNA-binding domain 304642 Ring finger 304645 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 304645 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 304649 SAM / Pointed domain 304649 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 304663 helix loop helix domain 304687 SERine Proteinase INhibitors 304688 SERine Proteinase INhibitors 304689 SERine Proteinase INhibitors 304690 SERine Proteinase INhibitors 304692 SERine Proteinase INhibitors 304697 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 304701 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 304705 Tyrosine kinase, catalytic domain 304705 Serine/Threonine protein kinases, catalytic domain 304709 Myosin. Large ATPases. ATPase 304709 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 304716 Tyrosine kinase, catalytic domain 304716 Serine/Threonine protein kinases, catalytic domain 304725 Laminin G domain 304727 Laminin G domain 304727 Coagulation factor 5/8 C-terminal domain, discoidin domain 304733 Band 4.1 homologues 304734 ankyrin repeats 304737 krueppel associated box 304742 Homeodomain 304760 HNH nucleases 304761 Zinc finger domain 304761 DEAD-like helicases superfamily 304761 helicase superfamily c-terminal domain 304766 Domain present in ubiquitin-regulatory proteins 304770 snRNP Sm proteins 304774 Immunoglobulin 304774 Immunoglobulin V-Type 304775 Tyrosine kinase, catalytic domain 304775 Serine/Threonine protein kinases, catalytic domain 304776 Tyrosine kinase, catalytic domain 304776 Serine/Threonine protein kinases, catalytic domain 304778 Src homology 3 domains 304778 GTPase-activator protein for Rho-like GTPases 304779 RNA recognition motif 304783 ARF-like small GTPases 304783 Rab subfamily of small GTPases 304783 Ras subfamily of RAS small GTPases 304783 Sar1p-like members of the Ras-family of small GTPases 304783 Rho (Ras homology) subfamily of Ras-like small GTPases 304783 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 304786 erythroblast transformation specific domain 304791 Tyrosine kinase, catalytic domain 304791 Serine/Threonine protein kinases, catalytic domain 304794 Tyrosine kinase, catalytic domain 304794 Serine/Threonine protein kinases, catalytic domain 304801 BED zinc finger 304813 ankyrin repeats 304815 SAM / Pointed domain 304815 erythroblast transformation specific domain 304818 ATPases associated with a variety of cellular activities 304822 Armadillo/beta-catenin-like repeats 304823 Immunoglobulin 304823 Immunoglobulin C-2 Type 304823 Fibronectin type 3 domain 304825 Laminin G domain 304838 Regulator of G protein signalling domain 304850 Ring finger 304853 Immunoglobulin 304853 Immunoglobulin C-2 Type 304858 Laminin N-terminal domain (domain VI) 304873 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 304878 Homeodomain 304878 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 304880 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 304887 Guanine nucleotide exchange factor for Ras-like small GTPases 304888 Fibrinogen-related domains (FReDs) 304889 Guanine nucleotide exchange factor for Ras-like small GTPases 304891 Src homology 2 domains 304892 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 304893 RNA recognition motif 304893 Protein kinase C conserved region 2 (CalB) 304893 GTPase-activator protein for Ras-like GTPases 304900 membrane-attack complex / perforin 304902 Domain abundant in complement control proteins 304903 Laminin G domain 304903 Domain found in Notch and Lin-12 304903 LamG-like jellyroll fold domain 304905 Ring finger 304913 Fibronectin type 3 domain 304913 Fibrinogen-related domains (FReDs) 304914 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 304917 SERine Proteinase INhibitors 304920 Kelch domain 304920 Broad-Complex, Tramtrack and Bric a brac 304922 Histidine kinase-like ATPases 304935 Domain first found in the mice T locus (Brachyury) protein 304941 krueppel associated box 304941 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 304947 Homeodomain 304957 Src homology 2 domains 304958 Src homology 2 domains 304960 Olfactomedin-like domains 304963 basic region leucin zipper 304965 Immunoglobulin 304965 Immunoglobulin C-2 Type 304966 Immunoglobulin 304966 Immunoglobulin C-2 Type 304967 Immunoglobulin 304967 Immunoglobulin C-2 Type 304978 WD40 repeats 304979 Immunoglobulin 304979 Immunoglobulin V-Type 304983 Calponin homology domain 304994 Formin Homology 2 Domain 304997 Chromatin organization modifier domain 305000 Xeroderma pigmentosum G I-region 305000 Xeroderma pigmentosum G N-region 305000 Helix-hairpin-helix class 2 (Pol1 family) motifs 305025 ankyrin repeats 305025 Ras association (RalGDS/AF-6) domain 305034 Histone H3 305034 Serine/Threonine protein kinases, catalytic domain 305034 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 305039 Dual specificity phosphatase, catalytic domain 305054 Fibronectin type 3 domain 305055 Broad-Complex, Tramtrack and Bric a brac 305063 Band 4.1 homologues 305064 Dual specificity phosphatase, catalytic domain 305064 Protein tyrosine phosphatase, catalytic domain 305064 Protein tyrosine phosphatase, catalytic domain motif 305072 14-3-3 homologues 305073 WD40 repeats 305074 Phosphate acyltransferases 305078 Laminin N-terminal domain (domain VI) 305078 Laminin-type epidermal growth factor-like domai 305083 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 305091 Tyrosine kinase, catalytic domain 305091 Serine/Threonine protein kinases, catalytic domain 305096 Kelch domain 305104 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 305111 krueppel associated box 305123 bromo domain 305124 DEAD-like helicases superfamily 305124 helicase superfamily c-terminal domain 305162 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 305166 Phosphate acyltransferases 305169 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 305178 RNA recognition motif 305185 Guanine nucleotide exchange factor for Ras-like GTPases 305185 Guanine nucleotide exchange factor for Ras-like small GTPases 305198 zinc finger 305232 Ribosomal protein L11/L12 305236 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 305240 RNA recognition motif 305241 Tyrosine kinase, catalytic domain 305241 Serine/Threonine protein kinases, catalytic domain 305244 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 305246 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 305251 Ras association (RalGDS/AF-6) domain 305253 Thrombospondin type 1 repeats 305256 RNA recognition motif 305265 Trypsin-like serine protease 305267 Trypsin-like serine protease 305267 Domain found in sea urchin sperm protein, enterokinase, agrin 305269 Src homology 2 domains 305269 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 305279 krueppel associated box 305293 Homeodomain 305295 Ring finger 305302 Rab subfamily of small GTPases 305302 Ras subfamily of RAS small GTPases 305302 Rho (Ras homology) subfamily of Ras-like small GTPases 305311 Src homology 2 domains 305311 Src homology 3 domains 305311 Tyrosine kinase, catalytic domain 305311 Serine/Threonine protein kinases, catalytic domain 305317 Rab subfamily of small GTPases 305317 Ras subfamily of RAS small GTPases 305331 Homeodomain 305332 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 305338 Domain with 2 conserved Trp (W) residues 305338 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 305340 RNA recognition motif 305341 Rab subfamily of small GTPases 305341 Ras subfamily of RAS small GTPases 305341 Rho (Ras homology) subfamily of Ras-like small GTPases 305341 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 305342 Small MutS-related domain 305351 Kelch domain 305351 Broad-Complex, Tramtrack and Bric a brac 305353 Toll - interleukin 1 - resistance 305353 Leucine rich repeat C-terminal domain 305354 Toll - interleukin 1 - resistance 305354 Leucine rich repeat C-terminal domain 305355 Toll - interleukin 1 - resistance 305360 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 305363 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305367 GTPase-activator protein for Rho-like GTPases 305367 Putative GTP-ase activating proteins for the small GTPase, ARF 305367 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 305367 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 305373 high mobility group 305375 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 305390 DEAD-like helicases superfamily 305399 EF-hand, calcium binding motif 305408 Leucine rich repeat C-terminal domain 305408 G-protein-coupled receptor proteolytic site domain 305417 Leucine rich repeat C-terminal domain 305423 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 305424 A Receptor for Ubiquitination Targets 305428 Broad-Complex, Tramtrack and Bric a brac 305431 Tyrosine kinase, catalytic domain 305431 Serine/Threonine protein kinases, catalytic domain 305438 VPS10 domain 305441 Src homology 3 domains 305445 Homeodomain 305450 Src homology 2 domains 305450 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 305454 Protein present in Fab1, YOTB, Vac1, and EEA1 305456 PHD zinc finger 305456 high mobility group 305456 associated with SET domains 305456 domain with conserved PWWP motif 305456 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 305464 Domain found in Dishevelled, Egl-10, and Pleckstrin 305470 ATPases associated with a variety of cellular activities 305471 Broad-Complex, Tramtrack and Bric a brac 305472 Kringle domain 305477 Protein tyrosine phosphatase, catalytic domain 305477 Dual specificity phosphatase, catalytic domain 305478 Ring finger 305479 Ubiquitin homologues 305479 Suppressor-of-White-APricot splicing regulator 305482 Protein present in Fab1, YOTB, Vac1, and EEA1 305484 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) 305494 Zn_pept domain 305494 Coagulation factor 5/8 C-terminal domain, discoidin domain 305500 Src homology 2 domains 305500 Ras association (RalGDS/AF-6) domain 305500 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 305503 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 305506 translation initiation factor 6 305509 Adenylyl- / guanylyl cyclase, catalytic domain 305521 Immunoglobulin 305539 WASP homology region 1 305547 Galectin 305556 Calponin homology domain 305581 Src homology 3 domains 305584 ig-like, plexins, transcription factors 305604 Calcium-binding EGF-like domain 305604 Epidermal growth factor-like domain 305613 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 305622 Ras association (RalGDS/AF-6) domain 305622 Diacylglycerol kinase accessory domain (presumed) 305622 Diacylglycerol kinase catalytic domain (presumed) 305622 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 305629 Tudor domain 305631 GTPase-activator protein for Rho-like GTPases 305635 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 305641 Myosin. Large ATPases. ATPase 305675 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 305681 Domain in histone families 1 and 5 305684 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 305705 Leucine rich repeat N-terminal domain 305709 C2C2 Zinc finger 305709 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 305709 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 305710 Tyrosine kinase, catalytic domain 305710 Serine/Threonine protein kinases, catalytic domain 305733 Ligand binding domain of hormone receptors 305734 c4 zinc finger in nuclear hormone receptors 305735 c4 zinc finger in nuclear hormone receptors 305744 RNA recognition motif 305751 Rab subfamily of small GTPases 305751 Ras subfamily of RAS small GTPases 305751 Rho (Ras homology) subfamily of Ras-like small GTPases 305755 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 305762 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305764 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 305764 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 305765 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305766 Ubiquitin homologues 305767 Ubiquitin homologues 305771 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305773 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305775 Ubiquitin homologues 305775 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305777 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 305778 Ubiquitin homologues 305792 Broad-Complex, Tramtrack and Bric a brac 305793 Serine/Threonine protein kinases, catalytic domain 305793 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 305797 Calponin homology domain 305798 ankyrin repeats 305801 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 305811 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 305814 Dual specificity phosphatase, catalytic domain 305820 Histone H3 305826 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 305827 WD40 repeats 305827 high mobility group 305828 Src homology 2 domains 305828 suppressors of cytokine signalling 305830 A Receptor for Ubiquitination Targets 305840 Pancreatic ribonuclease 305841 Pancreatic ribonuclease 305842 Pancreatic ribonuclease 305843 Pancreatic ribonuclease 305844 Pancreatic ribonuclease 305850 Protein kinase C conserved region 2 (CalB) 305853 ARF-like small GTPases 305853 Rab subfamily of small GTPases 305853 Ras subfamily of RAS small GTPases 305853 Rho (Ras homology) subfamily of Ras-like small GTPases 305853 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 305858 Homeodomain 305866 Immunoglobulin 305866 Immunoglobulin V-Type 305867 Immunoglobulin 305867 Immunoglobulin V-Type 305868 Immunoglobulin 305868 Immunoglobulin V-Type 305869 Immunoglobulin 305869 Immunoglobulin V-Type 305870 Immunoglobulin 305870 Immunoglobulin V-Type 305871 Immunoglobulin 305871 Immunoglobulin V-Type 305872 Immunoglobulin V-Type 305873 Immunoglobulin 305873 Immunoglobulin V-Type 305874 Immunoglobulin 305874 Immunoglobulin V-Type 305875 Immunoglobulin 305875 Immunoglobulin V-Type 305878 Immunoglobulin V-Type 305880 Low-density lipoprotein receptor domain class A 305880 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 305888 Homeodomain 305896 interferon regulatory factor 305899 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 305902 Trypsin-like serine protease 305903 Trypsin-like serine protease 305906 Trypsin-like serine protease 305908 Tudor domain 305908 B-Box C-terminal domain 305910 RNA recognition motif 305922 Tyrosine kinase, catalytic domain 305922 Extension to Ser/Thr-type protein kinases 305922 Serine/Threonine protein kinases, catalytic domain 305931 Methyl-CpG binding domain 305931 N-terminal to some SET domains 305931 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 305938 Src homology 3 domains 305938 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 305938 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 305938 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 305943 ARF-like small GTPases 305943 Rab subfamily of small GTPases 305943 Sar1p-like members of the Ras-family of small GTPases 305947 Broad-Complex, Tramtrack and Bric a brac 305951 WD40 repeats 305951 Protein present in Fab1, YOTB, Vac1, and EEA1 305956 WD40 repeats 305956 Protein present in Fab1, YOTB, Vac1, and EEA1 305967 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 305968 Homeodomain 305974 Scavenger receptor Cys-rich 305985 Broad-Complex, Tramtrack and Bric a brac 305986 Broad-Complex, Tramtrack and Bric a brac 305999 Homeodomain 306004 Rab subfamily of small GTPases 306004 Ras subfamily of RAS small GTPases 306004 Broad-Complex, Tramtrack and Bric a brac 306004 Rho (Ras homology) subfamily of Ras-like small GTPases 306006 BAR domain 306008 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 306013 Leucine rich repeat C-terminal domain 306013 Leucine-rich repeats, typical (most populated) subfamily 306022 Fibronectin type 3 domain 306038 RNA recognition motif 306044 Diacylglycerol kinase accessory domain (presumed) 306044 Diacylglycerol kinase catalytic domain (presumed) 306055 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 306060 Formin Homology 2 Domain 306066 Tudor domain 306071 Eps15 homology domain 306071 Calponin homology domain 306073 Broad-Complex, Tramtrack and Bric a brac 306081 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 306091 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 306097 domain in high mobilty group proteins HMG14 and HMG 17 306103 Large family of predicted nucleotide-binding domains 306117 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 306118 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 306129 A Receptor for Ubiquitination Targets 306147 Leucine rich repeat C-terminal domain 306152 Leucine rich repeat C-terminal domain 306166 ATPases associated with a variety of cellular activities 306168 high mobility group 306183 Band 4.1 homologues 306184 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 306184 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 306185 Tyrosine kinase, catalytic domain 306185 Serine/Threonine protein kinases, catalytic domain 306186 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 306194 Ubiquitin associated domain 306201 Ubiquitin homologues 306203 Serine/Threonine protein kinases, catalytic domain 306204 Filamin-type immunoglobulin domains 306205 Immunoglobulin 306205 Immunoglobulin V-Type 306208 Serine/Threonine protein kinases, catalytic domain 306222 snRNP Sm proteins 306226 Homeodomain 306243 von Willebrand factor (vWF) type A domain 306245 von Willebrand factor (vWF) type A domain 306252 Tyrosine kinase, catalytic domain 306252 Serine/Threonine protein kinases, catalytic domain 306260 calpain_III domain 306260 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 306264 ankyrin repeats 306268 Ricin-type beta-trefoil 306274 DEAD-like helicases superfamily 306274 helicase superfamily c-terminal domain 306279 GTPase-activator protein for Rho-like GTPases 306280 Band 4.1 homologues 306280 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 306281 Dual specificity phosphatase, catalytic domain 306281 Protein tyrosine phosphatase, catalytic domain 306281 Protein tyrosine phosphatase, catalytic domain motif 306283 Annexin repeats 306283 von Willebrand factor (vWF) type A domain 306285 Protein kinase C conserved region 2 (CalB) 306285 Protein kinase C conserved region 2 (CalB) 306288 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 306291 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 306292 Actin depolymerisation factor/cofilin -like domains 306293 Guanine nucleotide exchange factor for Ras-like GTPases 306294 Guanine nucleotide exchange factor for Ras-like GTPases 306297 Guanine nucleotide exchange factor for Ras-like GTPases 306298 Guanine nucleotide exchange factor for Ras-like GTPases 306299 Guanine nucleotide exchange factor for Ras-like GTPases 306301 Guanine nucleotide exchange factor for Ras-like GTPases 306302 Guanine nucleotide exchange factor for Ras-like GTPases 306328 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 306333 Src homology 2 domains 306334 krueppel associated box 306335 krueppel associated box 306351 Transforming growth factor-beta (TGF-beta) family 306356 Immunoglobulin 306356 Immunoglobulin C-2 Type 306357 Fes/CIP4 homology domain 306357 GTPase-activator protein for Rho-like GTPases 306357 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 306358 krueppel associated box 306359 krueppel associated box 306360 krueppel associated box 306361 krueppel associated box 306363 krueppel associated box 306364 krueppel associated box 306376 Src homology 2 domains 306384 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 306399 Zn_pept domain 306400 GTPase-activator protein for Rho-like GTPases 306402 high mobility group 306404 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 306409 DEAD-like helicases superfamily 306409 helicase superfamily c-terminal domain 306412 Immunoglobulin 306412 Immunoglobulin C-2 Type 306417 Src homology 3 domains 306419 Ring finger 306421 Domain with 2 conserved Trp (W) residues 306424 Immunoglobulin 306431 Ubiquitin homologues 306436 Sec7 domain 306441 WD40 repeats 306444 RNA recognition motif 306444 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 306456 Ubiquitin homologues 306462 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 306471 Regulator of G protein signalling domain 306471 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 306496 Scavenger receptor Cys-rich 306501 Ribosomal protein S1-like RNA-binding domain 306505 Histone H2B 306505 Ring finger 306506 Tyrosine kinase, catalytic domain 306506 Serine/Threonine protein kinases, catalytic domain 306527 Protein tyrosine phosphatase, catalytic domain 306527 Dual specificity phosphatase, catalytic domain 306527 Protein tyrosine phosphatase, catalytic domain motif 306535 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 306547 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 306549 Tyrosine kinase, catalytic domain 306549 Serine/Threonine protein kinases, catalytic domain 306552 snRNP Sm proteins 306555 Acid phosphatase homologues 306564 Insulin growth factor-binding protein homologues 306564 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 306567 Frizzled 306571 PHD zinc finger 306576 Tyrosine kinase, catalytic domain 306576 Serine/Threonine protein kinases, catalytic domain 306577 Tyrosine kinase, catalytic domain 306577 Serine/Threonine protein kinases, catalytic domain 306579 Defensin/corticostatin family 306582 Phosphate acyltransferases 306589 Kelch domain 306594 breast cancer carboxy-terminal domain 306597 high mobility group 306605 Protein kinase C conserved region 2 (CalB) 306606 Bruton's tyrosine kinase Cys-rich motif 306606 GTPase-activator protein for Ras-like GTPases 306606 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 306608 Trypsin-like serine protease 306608 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 306609 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 306613 Domain abundant in complement control proteins 306613 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 306619 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 306624 Calponin homology domain 306626 PHD zinc finger 306627 Rab subfamily of small GTPases 306627 Ras subfamily of RAS small GTPases 306627 Rho (Ras homology) subfamily of Ras-like small GTPases 306643 Broad-Complex, Tramtrack and Bric a brac 306655 Homeodomain 306657 Homeodomain 306659 Homeodomain 306663 Thrombospondin type 1 repeats 306664 Thrombospondin type 1 repeats 306669 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 306675 krueppel associated box 306678 krueppel associated box 306679 krueppel associated box 306680 krueppel associated box 306681 krueppel associated box 306683 EF-hand, calcium binding motif 306685 Trypsin-like serine protease 306690 RNA recognition motif 306694 Dual specificity phosphatase, catalytic domain 306694 Protein tyrosine phosphatase, catalytic domain 306694 Protein tyrosine phosphatase, catalytic domain motif 306698 DEAD-like helicases superfamily 306698 helicase superfamily c-terminal domain 306705 krueppel associated box 306706 krueppel associated box 306708 krueppel associated box 306709 krueppel associated box 306711 krueppel associated box 306714 krueppel associated box 306715 krueppel associated box 306717 krueppel associated box 306718 Papain family cysteine protease 306719 Papain family cysteine protease 306720 Papain family cysteine protease 306720 Papain family cysteine protease 306722 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 306736 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 306739 Kelch domain 306750 A Receptor for Ubiquitination Targets 306759 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 306760 Phosphotyrosine-binding domain (IRS1-like) 306761 Kringle domain 306761 Fibronectin type 1 domain 306761 Fibronectin type 2 domain 306761 Trypsin-like serine protease 306761 Calcium-binding EGF-like domain 306764 PHD zinc finger 306764 associated with SET domains 306764 domain with conserved PWWP motif 306764 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 306765 U1-like zinc finger 306767 ARF-like small GTPases 306767 Sar1p-like members of the Ras-family of small GTPases 306782 Immunoglobulin 306782 Kringle domain 306782 Immunoglobulin C-2 Type 306782 Tyrosine kinase, catalytic domain 306782 Serine/Threonine protein kinases, catalytic domain 306790 Immunoglobulin 306790 semaphorin domain 306790 domain found in Plexins, Semaphorins and Integrins 306802 Tyrosine kinase, catalytic domain 306802 Serine/Threonine protein kinases, catalytic domain 306803 high mobility group 306803 Tyrosine kinase, catalytic domain 306803 Serine/Threonine protein kinases, catalytic domain 306807 Leucine rich repeat N-terminal domain 306810 Domain abundant in complement control proteins 306811 Tyrosine kinase, catalytic domain 306811 Serine/Threonine protein kinases, catalytic domain 306812 Extension to Ser/Thr-type protein kinases 306812 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 306816 krueppel associated box 306817 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 306818 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 306825 Band 4.1 homologues 306827 Histone H3 306831 Immunoglobulin 306844 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 306886 Tyrosine kinase, catalytic domain 306886 Serine/Threonine protein kinases, catalytic domain 306886 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 306889 SERine Proteinase INhibitors 306890 SERine Proteinase INhibitors 306891 SERine Proteinase INhibitors 306892 SERine Proteinase INhibitors 306894 SERine Proteinase INhibitors 306895 Ubiquitin homologues 306896 Tyrosine kinase, catalytic domain 306896 Serine/Threonine protein kinases, catalytic domain 306900 FORKHEAD 306945 Histone H2B 306947 Domain in histone families 1 and 5 306948 Histone H2B 306949 Histone H4 306955 Histone H4 306956 Immunoglobulin 306956 Immunoglobulin V-Type 306956 associated with SPRY domains 306956 Domain in SPla and the RYanodine Receptor. 306957 Immunoglobulin 306957 Immunoglobulin V-Type 306957 associated with SPRY domains 306957 Domain in SPla and the RYanodine Receptor. 306958 Immunoglobulin 306958 Immunoglobulin V-Type 306958 associated with SPRY domains 306958 Domain in SPla and the RYanodine Receptor. 306961 WD40 repeats 306962 Histone 2A 306963 Histone H4 306964 Histone H2B 306966 krueppel associated box 306967 Histone H2B 306968 Histone 2A 306969 Histone H2B 306970 Histone 2A 306971 Histone H3 306972 Histone 2A 306973 Histone H4 306974 leucine rich region 306974 krueppel associated box 306975 leucine rich region 306977 leucine rich region 306977 krueppel associated box 306987 Immunoglobulin C-Type 306990 Clathrin heavy chain repeat homology 306993 Homeodomain 306993 Found in Pit-Oct-Unc transcription factors 306998 Tyrosine kinase, catalytic domain 306998 Serine/Threonine protein kinases, catalytic domain 307007 Domain Homologous to E6-AP Carboxyl Terminus with 307010 WD40 repeats 307011 Domain with 2 conserved Trp (W) residues 307011 Domain Homologous to E6-AP Carboxyl Terminus with 307016 Src homology 3 domains 307016 Domain with 2 conserved Trp (W) residues 307016 GTPase-activator protein for Rho-like GTPases 307035 Src homology 3 domains 307035 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 307036 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 307039 ARF-like small GTPases 307039 Rab subfamily of small GTPases 307039 Ras subfamily of RAS small GTPases 307039 Sar1p-like members of the Ras-family of small GTPases 307039 Rho (Ras homology) subfamily of Ras-like small GTPases 307039 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 307040 Guanine nucleotide exchange factor for Ras-like GTPases 307043 Tyrosine kinase, catalytic domain 307043 Serine/Threonine protein kinases, catalytic domain 307046 Guanine nucleotide exchange factor for Ras-like GTPases 307056 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 307057 ankyrin repeats 307070 RNA recognition motif 307070 Domain in the RNA-binding Lupus La protein 307075 WD40 repeats 307098 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 307098 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 307099 Eps15 homology domain 307099 EF-hand, calcium binding motif 307100 Eps15 homology domain 307100 EF-hand, calcium binding motif 307101 ankyrin repeats 307101 suppressors of cytokine signalling 307106 SAM / Pointed domain 307106 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 307107 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 307108 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 307109 PHD zinc finger 307114 translation initiation factor 6 307123 Serine/Threonine protein kinases, catalytic domain 307124 Serine/Threonine protein kinases, catalytic domain 307137 DnaJ molecular chaperone homology domain 307142 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 307144 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 307148 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 307151 Ring finger 307151 Armadillo/beta-catenin-like repeats 307154 RNA recognition motif 307156 Armadillo/beta-catenin-like repeats 307168 Tyrosine kinase, catalytic domain 307168 Serine/Threonine protein kinases, catalytic domain 307169 Tyrosine kinase, catalytic domain 307169 Extension to Ser/Thr-type protein kinases 307169 Serine/Threonine protein kinases, catalytic domain 307171 Ras association (RalGDS/AF-6) domain 307178 GTPase-activator protein for Rho-like GTPases 307178 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 307178 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 307182 Guanine nucleotide exchange factor for Ras-like GTPases 307189 Src homology 3 domains 307189 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 307200 Src homology 2 domains 307200 suppressors of cytokine signalling 307202 Histone 2A 307205 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 307209 A Receptor for Ubiquitination Targets 307236 Homeodomain 307237 PB1 domain 307237 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 307239 high mobility group 307248 Fes/CIP4 homology domain 307251 Ring finger 307253 ATPases associated with a variety of cellular activities 307266 Tyrosine kinase, catalytic domain 307266 Serine/Threonine protein kinases, catalytic domain 307267 Serine/Threonine protein kinases, catalytic domain 307271 Ring finger 307271 K homology RNA-binding domain 307288 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 307305 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 307332 Ring finger 307350 ATPases associated with a variety of cellular activities 307353 G protein alpha subunit 307366 Immunoglobulin 307366 Immunoglobulin C-2 Type 307370 Immunoglobulin 307371 Domain Homologous to E6-AP Carboxyl Terminus with 307376 Homeodomain 307384 Kazal type serine protease inhibitors 307393 Src homology 3 domains 307394 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 307395 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 307398 BAR domain 307398 Src homology 3 domains 307398 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 307401 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa 307401 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 307402 high mobility group 307403 Immunoglobulin 307403 Immunoglobulin C-2 Type 307403 Tyrosine kinase, catalytic domain 307403 Serine/Threonine protein kinases, catalytic domain 307410 zinc finger 307410 RNA recognition motif 307427 WD40 repeats 307431 high mobility group 307432 RNA recognition motif 307433 RNA recognition motif 307438 Domain in SPla and the RYanodine Receptor. 307441 high mobility group 307446 DEAD-like helicases superfamily 307448 Found in Skp1 protein family 307451 Kazal type serine protease inhibitors 307452 Domain in the RNA-binding Lupus La protein 307459 BAR domain 307459 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 307465 Armadillo/beta-catenin-like repeats 307471 Ring finger 307472 Src homology 3 domains 307474 Contains two conserved F residues 307474 Domain with 2 conserved Trp (W) residues 307476 Ubiquitin homologues 307480 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 307481 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307482 Src homology 3 domains 307482 Fes/CIP4 homology domain 307482 GTPase-activator protein for Rho-like GTPases 307482 Putative GTP-ase activating proteins for the small GTPase, ARF 307482 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 307482 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 307486 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307487 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307488 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307489 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307490 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307498 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria 307500 Sec7 domain 307500 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 307511 Rhodanese Homology Domain 307523 Band 4.1 homologues 307523 Myosin. Large ATPases. ATPase 307523 Domain in Myosin and Kinesin Tails 307524 WD40 repeats 307525 DNA-directed RNA-polymerase II subunit 307540 RNA recognition motif 307557 Kelch domain 307561 Ring finger 307561 Modified RING finger domain 307562 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307563 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307582 Laminin B domain 307582 Laminin G domain 307582 Laminin N-terminal domain (domain VI) 307582 Laminin-type epidermal growth factor-like domai 307582 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 307594 ankyrin repeats 307614 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307618 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307623 Immunoglobulin 307623 Immunoglobulin V-Type 307631 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 307641 Tyrosine kinase, catalytic domain 307641 Serine/Threonine protein kinases, catalytic domain 307657 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 307667 high mobility group 307672 Myosin. Large ATPases. ATPase 307674 Myosin. Large ATPases. ATPase 307675 Myosin. Large ATPases. ATPase 307694 Myosin. Large ATPases. ATPase 307696 Myosin. Large ATPases. ATPase 307700 Myosin. Large ATPases. ATPase 307707 Myosin. Large ATPases. ATPase 307711 EF-hand, calcium binding motif 307713 Phosphate acyltransferases 307715 Homeodomain 307724 Protein kinase C conserved region 2 (CalB) 307726 domain in transcription and CHROMO domain helicases 307727 DEAD-like helicases superfamily 307727 helicase superfamily c-terminal domain 307744 Adenylyl- / guanylyl cyclase, catalytic domain 307749 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 307757 Low-density lipoprotein receptor domain class A 307757 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 307761 Serine/Threonine protein kinases, catalytic domain 307766 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 307767 Domains in Na-Ca exchangers and integrin-beta4 307771 krueppel associated box 307779 RRM_1 domain 307779 RNA recognition motif 307796 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 307799 PB1 domain 307799 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 307802 RNA recognition motif 307803 ig-like, plexins, transcription factors 307806 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 307808 Serine/Threonine protein kinases, catalytic domain 307810 RNA recognition motif 307815 krueppel associated box 307821 JAB/MPN domain 307829 Homeodomain 307835 Hint (Hedgehog/Intein) domain N-terminal region 307835 domain in Ataxins and HMG containing proteins 307836 Serine/threonine phosphatases, family 2C, catalytic domain 307839 krueppel associated box 307849 DEAD-like helicases superfamily 307849 helicase superfamily c-terminal domain 307851 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 307851 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 307855 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 307860 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 307872 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 307893 Kelch domain 307893 Broad-Complex, Tramtrack and Bric a brac 307900 Broad-Complex, Tramtrack and Bric a brac 307901 domain in TBC and LysM domain containing proteins 307902 Actin depolymerisation factor/cofilin -like domains 307903 Kelch domain 307903 Broad-Complex, Tramtrack and Bric a brac 307916 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases 307919 Ring finger 307920 RNA recognition motif 307923 Domain present in VPS9 307927 WD40 repeats 307935 B-Box-type zinc finger 307938 B-Box C-terminal domain 307938 Fibronectin type 3 domain 307938 Domain in SPla and the RYanodine Receptor. 307939 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 307950 Src homology 3 domains 307950 Tyrosine kinase, catalytic domain 307950 Serine/Threonine protein kinases, catalytic domain 307956 RNA recognition motif 307968 Protein kinase C conserved region 2 (CalB) 307970 Hint (Hedgehog/Intein) domain N-terminal region 307970 domain in Ataxins and HMG containing proteins 307973 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 307979 high mobility group 307982 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 307983 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 307983 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 307988 Calcium-binding EGF-like domain 307988 von Willebrand factor (vWF) type A domain 307989 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 307992 delta serrate ligand 307992 Laminin-type epidermal growth factor-like domai 307992 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 308000 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 308000 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 308001 Homeodomain 308003 Protein kinase C conserved region 2 (CalB) 308011 krueppel associated box 308012 krueppel associated box 308015 von Willebrand factor (vWF) type A domain 308016 von Willebrand factor (vWF) type A domain 308021 GTPase-activator protein for Rho-like GTPases 308026 Tyrosine kinase, catalytic domain 308026 Serine/Threonine protein kinases, catalytic domain 308032 krueppel associated box 308037 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 308044 Lysin motif 308044 domain in TBC and LysM domain containing proteins 308049 Thrombospondin type 1 repeats 308051 Ring finger 308051 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis 308062 PAS domain 308067 bromo domain 308072 Serine/Threonine protein kinases, catalytic domain 308074 Tyrosine kinase, catalytic domain 308074 Serine/Threonine protein kinases, catalytic domain 308075 Serine/Threonine protein kinases, catalytic domain 308076 RIO-like kinase 308076 Ubiquitin associated domain 308076 Tyrosine kinase, catalytic domain 308076 Serine/Threonine protein kinases, catalytic domain 308078 RIO-like kinase 308078 Tyrosine kinase, catalytic domain 308078 Serine/Threonine protein kinases, catalytic domain 308079 Serine/Threonine protein kinases, catalytic domain 308080 Tyrosine kinase, catalytic domain 308080 Serine/Threonine protein kinases, catalytic domain 308086 ARID (A/T-rich interaction domain) domain 308097 GTPase-activator protein for Rho-like GTPases 308099 Fibronectin type 3 domain 308106 Tyrosine kinase, catalytic domain 308106 Serine/Threonine protein kinases, catalytic domain 308113 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 308113 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 308118 Regulator of G protein signalling domain 308119 Glucagon like hormones 308121 Calponin homology domain 308126 Broad-Complex, Tramtrack and Bric a brac 308127 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 308130 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 308131 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 308136 ARF-like small GTPases 308136 Rab subfamily of small GTPases 308136 Sar1p-like members of the Ras-family of small GTPases 308140 Ribosomal RNA adenine dimethylases 308142 Raf-like Ras-binding domain 308142 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 308142 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 308142 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 308170 Tyrosine kinase, catalytic domain 308170 Serine/Threonine protein kinases, catalytic domain 308172 Serine/Threonine protein kinases, catalytic domain 308173 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 308177 ARID (A/T-rich interaction domain) domain 308183 RIO-like kinase 308183 Tyrosine kinase, catalytic domain 308183 Serine/Threonine protein kinases, catalytic domain 308184 Tyrosine kinase, catalytic domain 308184 Serine/Threonine protein kinases, catalytic domain 308185 RIO-like kinase 308185 Tyrosine kinase, catalytic domain 308185 Serine/Threonine protein kinases, catalytic domain 308186 RIO-like kinase 308186 Tyrosine kinase, catalytic domain 308186 Serine/Threonine protein kinases, catalytic domain 308187 Serine/Threonine protein kinases, catalytic domain 308188 RIO-like kinase 308188 Tyrosine kinase, catalytic domain 308188 Serine/Threonine protein kinases, catalytic domain 308191 ankyrin repeats 308191 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 308193 RIO-like kinase 308193 Tyrosine kinase, catalytic domain 308193 Serine/Threonine protein kinases, catalytic domain 308194 RIO-like kinase 308194 Tyrosine kinase, catalytic domain 308194 Serine/Threonine protein kinases, catalytic domain 308195 Tyrosine kinase, catalytic domain 308195 Serine/Threonine protein kinases, catalytic domain 308196 Ubiquitin associated domain 308196 Serine/Threonine protein kinases, catalytic domain 308197 RIO-like kinase 308197 Tyrosine kinase, catalytic domain 308197 Serine/Threonine protein kinases, catalytic domain 308198 RIO-like kinase 308198 Tyrosine kinase, catalytic domain 308198 Serine/Threonine protein kinases, catalytic domain 308199 RIO-like kinase 308199 Ubiquitin associated domain 308199 Tyrosine kinase, catalytic domain 308199 Serine/Threonine protein kinases, catalytic domain 308201 RIO-like kinase 308203 Band 4.1 homologues 308203 Tyrosine kinase, catalytic domain 308203 Serine/Threonine protein kinases, catalytic domain 308204 Tyrosine kinase, catalytic domain 308204 Serine/Threonine protein kinases, catalytic domain 308205 RIO-like kinase 308205 Tyrosine kinase, catalytic domain 308205 Serine/Threonine protein kinases, catalytic domain 308209 RIO-like kinase 308209 Tyrosine kinase, catalytic domain 308209 Serine/Threonine protein kinases, catalytic domain 308209 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 308210 high mobility group 308210 Ras association (RalGDS/AF-6) domain 308211 Tyrosine kinase, catalytic domain 308211 Serine/Threonine protein kinases, catalytic domain 308213 Kazal type serine protease inhibitors 308213 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 308214 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 308223 Immunoglobulin 308224 WD40 repeats 308231 krueppel associated box 308232 krueppel associated box 308233 krueppel associated box 308234 krueppel associated box 308236 krueppel associated box 308238 krueppel associated box 308239 krueppel associated box 308240 Tyrosine kinase, catalytic domain 308240 Serine/Threonine protein kinases, catalytic domain 308241 krueppel associated box 308242 krueppel associated box 308243 krueppel associated box 308244 krueppel associated box 308247 Serine/Threonine protein kinases, catalytic domain 308252 krueppel associated box 308254 zinc finger 308255 krueppel associated box 308256 krueppel associated box 308265 Tyrosine kinase, catalytic domain 308265 Serine/Threonine protein kinases, catalytic domain 308267 Zinc finger domain 308282 Ring finger 308282 PHD zinc finger 308282 DEAD-like helicases superfamily 308282 Domain in histone families 1 and 5 308282 helicase superfamily c-terminal domain 308287 zinc finger 308297 krueppel associated box 308298 krueppel associated box 308300 krueppel associated box 308301 DEAD-like helicases superfamily 308301 helicase superfamily c-terminal domain 308307 krueppel associated box 308316 krueppel associated box 308318 krueppel associated box 308320 krueppel associated box 308322 krueppel associated box 308324 krueppel associated box 308325 krueppel associated box 308326 krueppel associated box 308331 Homeodomain 308332 Serine/Threonine protein kinases, catalytic domain 308335 RNA recognition motif 308340 Tyrosine kinase, catalytic domain 308340 Serine/Threonine protein kinases, catalytic domain 308341 Scavenger receptor Cys-rich 308345 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 308347 RIO-like kinase 308347 Tyrosine kinase, catalytic domain 308347 Serine/Threonine protein kinases, catalytic domain 308355 leucine rich region 308359 leucine rich region 308362 leucine rich region 308362 krueppel associated box 308363 krueppel associated box 308365 leucine rich region 308365 krueppel associated box 308369 RNA recognition motif 308372 high mobility group 308376 G-protein-coupled receptor proteolytic site domain 308379 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 308385 zinc finger 308388 GTPase-activator protein for Rho-like GTPases 308389 Rab subfamily of small GTPases 308389 Contains two conserved F residues 308389 Ras subfamily of RAS small GTPases 308392 WD40 repeats 308394 Immunoglobulin 308394 Immunoglobulin C-2 Type 308395 Immunoglobulin 308395 Immunoglobulin C-2 Type 308396 Immunoglobulin 308396 Immunoglobulin C-2 Type 308399 Immunoglobulin 308399 Immunoglobulin C-2 Type 308400 Actin depolymerisation factor/cofilin -like domains 308401 WD40 repeats 308402 Immunoglobulin C-Type 308402 K homology RNA-binding domain 308405 Tyrosine kinase, catalytic domain 308405 Extension to Ser/Thr-type protein kinases 308405 Serine/Threonine protein kinases, catalytic domain 308407 high mobility group 308415 DEAD-like helicases superfamily 308415 helicase superfamily c-terminal domain 308417 Immunoglobulin 308417 Immunoglobulin V-Type 308418 Immunoglobulin 308418 Immunoglobulin C-2 Type 308419 Immunoglobulin C-2 Type 308420 krueppel associated box 308420 Rab subfamily of small GTPases 308420 Ras subfamily of RAS small GTPases 308420 Rho (Ras homology) subfamily of Ras-like small GTPases 308421 krueppel associated box 308422 krueppel associated box 308423 krueppel associated box 308424 krueppel associated box 308431 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 308435 high mobility group 308444 Immunoglobulin 308444 Immunoglobulin C-2 Type 308444 Fibronectin type 3 domain 308444 Tyrosine kinase, catalytic domain 308444 Serine/Threonine protein kinases, catalytic domain 308446 Middle domain of eukaryotic initiation factor 4G (eIF4G) 308446 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 308448 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 308449 Tyrosine kinase, catalytic domain 308449 Serine/Threonine protein kinases, catalytic domain 308454 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 308455 Spectrin repeats 308455 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 308457 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 308457 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 308458 Spectrin repeats 308458 Calponin homology domain 308459 Calponin homology domain 308461 Tyrosine kinase, catalytic domain 308461 Serine/Threonine protein kinases, catalytic domain 308463 Src homology 3 domains 308463 Tyrosine kinase, catalytic domain 308463 Serine/Threonine protein kinases, catalytic domain 308464 krueppel associated box 308465 krueppel associated box 308466 krueppel associated box 308467 krueppel associated box 308468 Tyrosine kinase, catalytic domain 308468 Serine/Threonine protein kinases, catalytic domain 308473 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 308476 calpain_III domain 308476 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 308478 WASP homology region 1 308482 krueppel associated box 308483 krueppel associated box 308485 krueppel associated box 308486 krueppel associated box 308487 krueppel associated box 308488 krueppel associated box 308489 krueppel associated box 308490 krueppel associated box 308490 DEAD-like helicases superfamily 308490 helicase superfamily c-terminal domain 308491 krueppel associated box 308492 WD40 repeats 308495 Immunoglobulin 308495 Immunoglobulin C-2 Type 308495 Fibronectin type 3 domain 308497 amyloid A4 308498 Src homology 3 domains 308498 GTPase-activator protein for Rho-like GTPases 308501 Immunoglobulin 308501 Immunoglobulin C-2 Type 308506 Uteroglobin 308507 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 308523 Homeodomain 308532 krueppel associated box 308533 krueppel associated box 308534 Src homology 2 domains 308535 krueppel associated box 308541 krueppel associated box 308542 Protein present in Fab1, YOTB, Vac1, and EEA1 308542 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 308543 Protein present in Fab1, YOTB, Vac1, and EEA1 308543 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 308550 krueppel associated box 308550 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 308553 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 308554 krueppel associated box 308556 Immunoglobulin 308556 Immunoglobulin C-2 Type 308557 Immunoglobulin 308557 Immunoglobulin C-2 Type 308558 Immunoglobulin V-Type 308559 krueppel associated box 308560 krueppel associated box 308561 Immunoglobulin 308561 Immunoglobulin C-2 Type 308561 krueppel associated box 308562 Trypsin-like serine protease 308564 Trypsin-like serine protease 308565 Trypsin-like serine protease 308566 Trypsin-like serine protease 308571 Immunoglobulin 308571 Leucine rich repeat C-terminal domain 308582 TEA domain 308584 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 308587 Netrin C-terminal Domain 308587 Laminin-type epidermal growth factor-like domai 308589 Diacylglycerol kinase catalytic domain (presumed) 308592 WD40 repeats 308595 Immunoglobulin 308595 Immunoglobulin C-Type 308597 Serum amyloid A proteins 308600 Homeodomain 308600 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 308623 Histidine kinase-like ATPases 308649 Tyrosine kinase, catalytic domain 308649 Serine/Threonine protein kinases, catalytic domain 308650 RNA recognition motif 308662 RNA recognition motif 308669 Domain Homologous to E6-AP Carboxyl Terminus with 308669 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 308703 Rab subfamily of small GTPases 308703 Tyrosine kinase, catalytic domain 308703 Serine/Threonine protein kinases, catalytic domain 308718 WD40 repeats 308725 high mobility group 308738 DEAD-like helicases superfamily 308738 Chromatin organization modifier domain 308738 helicase superfamily c-terminal domain 308742 Protein kinase C conserved region 2 (CalB) 308755 Helicase and RNase D C-terminal 308764 snRNP Sm proteins 308766 helix loop helix domain 308767 snRNP Sm proteins 308773 Immunoglobulin 308773 Immunoglobulin V-Type 308773 Link (Hyaluronan-binding) 308779 Fibronectin type 3 domain 308779 associated with SPRY domains 308779 Domain in SPla and the RYanodine Receptor. 308786 Thrombospondin type 1 repeats 308787 Immunoglobulin 308787 Immunoglobulin C-2 Type 308787 Thrombospondin type 1 repeats 308790 K homology RNA-binding domain 308792 in StAR and phosphatidylcholine transfer protein 308801 Rab subfamily of small GTPases 308801 Ras subfamily of RAS small GTPases 308801 Rho (Ras homology) subfamily of Ras-like small GTPases 308801 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 308807 Trypsin-like serine protease 308813 Epsin N-terminal homology (ENTH) domain 308821 ARF-like small GTPases 308821 Rab subfamily of small GTPases 308821 Ras subfamily of RAS small GTPases 308821 Rho (Ras homology) subfamily of Ras-like small GTPases 308821 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 308835 Broad-Complex, Tramtrack and Bric a brac 308836 Broad-Complex, Tramtrack and Bric a brac 308839 PHD zinc finger 308842 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 308845 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 308850 Kelch domain 308850 Broad-Complex, Tramtrack and Bric a brac 308851 Leucine rich repeat C-terminal domain 308854 von Willebrand factor (vWF) type C domain 308857 DnaJ molecular chaperone homology domain 308864 Src homology 3 domains 308865 WD40 repeats 308867 Ribosomal protein L11/L12 308875 Rab subfamily of small GTPases 308875 Ras subfamily of RAS small GTPases 308875 Rho (Ras homology) subfamily of Ras-like small GTPases 308875 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 308887 Rab subfamily of small GTPases 308887 Ras subfamily of RAS small GTPases 308887 Rho (Ras homology) subfamily of Ras-like small GTPases 308887 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 308890 Broad-Complex, Tramtrack and Bric a brac 308894 Ras association (RalGDS/AF-6) domain 308900 Ring finger 308901 Ring finger 308901 B-Box-type zinc finger 308901 Modified RING finger domain 308901 associated with SPRY domains 308901 Domain in SPla and the RYanodine Receptor. 308902 Ras subfamily of RAS small GTPases 308904 basic region leucin zipper 308905 Ubiquitin homologues 308905 Ubiquitin associated domain 308906 Ring finger 308906 B-Box-type zinc finger 308906 Domain in SPla and the RYanodine Receptor. 308907 Domain in SPla and the RYanodine Receptor. 308913 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 308917 Olfactomedin-like domains 308919 Trypsin-like serine protease 308919 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 308923 WD40 repeats 308925 Src homology 3 domains 308928 high mobility group 308937 Tyrosine kinase, catalytic domain 308937 Serine/Threonine protein kinases, catalytic domain 308942 domain involved in Ras-like GTPase signaling 308946 Tyrosine kinase, catalytic domain 308946 Serine/Threonine protein kinases, catalytic domain 308951 RNA recognition motif 308954 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 308956 von Willebrand factor (vWF) type A domain 308968 zinc finger 308968 Ring finger 308972 RNA recognition motif 308988 Domain abundant in complement control proteins 308988 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 308995 von Willebrand factor (vWF) type A domain 308995 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 308997 krueppel associated box 309001 RNA recognition motif 309001 Cysteine-rich motif following a subset of SET domains 309001 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 309007 RNA recognition motif 309010 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 309014 Acid phosphatase homologues 309027 Zona pellucida (ZP) domain 309027 Scavenger receptor Cys-rich 309032 WD40 repeats 309036 RNA recognition motif 309036 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 309044 Ubiquitin homologues 309047 high mobility group 309055 Coagulation factor 5/8 C-terminal domain, discoidin domain 309071 ankyrin repeats 309071 Fibronectin type 3 domain 309077 Src homology 3 domains 309081 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 309094 Inositol polyphosphate phosphatase, catalytic domain homologues 309095 Homeodomain 309098 ADAM Cysteine-Rich Domain 309098 Homologues of snake disintegrins 309106 Toll - interleukin 1 - resistance 309169 Calponin homology domain 309172 Band 4.1 homologues 309174 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 309175 P21-Rho-binding domain 309185 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family 309186 Band 4.1 homologues 309186 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 309192 WD40 repeats 309195 Broad-Complex, Tramtrack and Bric a brac 309197 Domain in SPla and the RYanodine Receptor. 309198 Fibronectin type 3 domain 309224 RNA polymerase subunit CX 309240 G protein alpha subunit 309242 ARF-like small GTPases 309242 G protein alpha subunit 309242 Sar1p-like members of the Ras-family of small GTPases 309246 FORKHEAD 309250 domain in high mobilty group proteins HMG14 and HMG 17 309264 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 309275 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 309279 deoxyribonuclease I 309280 semaphorin domain 309280 ig-like, plexins, transcription factors 309280 GTPase-activator protein for Ras-like GTPases 309280 domain found in Plexins, Semaphorins and Integrins 309288 Ligand binding domain of hormone receptors 309292 RNA recognition motif 309302 Immunoglobulin 309302 Immunoglobulin V-Type 309304 Immunoglobulin 309320 Histone H3 309325 bromo domain 309331 PHD zinc finger 309331 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. Domain in SET domain containing proteins and in Deinococcus radiodurans DRA1533 309334 Cyclic nucleotide-monophosphate binding domain 309338 RRM_1 domain 309338 RNA recognition motif 309339 Cyclic nucleotide-monophosphate binding domain 309349 Leucine rich repeat C-terminal domain 309350 Histone H3 309361 Tyrosine kinase, catalytic domain 309361 Serine/Threonine protein kinases, catalytic domain 309362 BAR domain 309362 Src homology 3 domains 309362 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 309368 Laminin N-terminal domain (domain VI) 309368 Laminin-type epidermal growth factor-like domai 309369 snRNP Sm proteins 309373 Ubiquitin homologues 309374 ankyrin repeats 309376 Protein present in Fab1, YOTB, Vac1, and EEA1 309377 Frizzled 309377 Netrin C-terminal Domain 309382 Broad-Complex, Tramtrack and Bric a brac 309384 Tyrosine kinase, catalytic domain 309384 Serine/Threonine protein kinases, catalytic domain 309389 Homeodomain 309410 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 309419 Phosphatidylinositol phosphate kinases 309430 Doublesex DNA-binding motif 309433 WD40 repeats 309437 Paired Box domain 309451 Sec7 domain 309452 ankyrin repeats 309452 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 309457 Ring finger 309458 Ribosomal protein S1-like RNA-binding domain 309459 domain in neuralized proteins 309460 Src homology 3 domains 309476 Calcium-binding EGF-like domain 309476 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 309495 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 309499 Protein kinase C conserved region 2 (CalB) 309500 Protein kinase C conserved region 2 (CalB) 309500 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 309501 Protein kinase C conserved region 2 (CalB) 309508 RNA recognition motif 309511 DEAD-like helicases superfamily 309511 helicase superfamily c-terminal domain 309512 ankyrin repeats 309512 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 309514 Domain Homologous to E6-AP Carboxyl Terminus with 309523 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 309532 ATPases associated with a variety of cellular activities 309533 VPS10 domain 309543 krueppel associated box 309544 U1-like zinc finger 309544 RNA recognition motif 309550 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 309552 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 309558 domain present in cyclins, TFIIB and Retinoblastoma 309576 Actin depolymerisation factor/cofilin -like domains 309583 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 309584 Immunoglobulin C-Type 309585 B-Box-type zinc finger 309586 Ring finger 309586 Immunoglobulin C-Type 309586 B-Box-type zinc finger 309586 associated with SPRY domains 309586 Domain in SPla and the RYanodine Receptor. 309587 Immunoglobulin C-Type 309588 Immunoglobulin C-Type 309590 Immunoglobulin C-Type 309591 Ring finger 309591 B-Box-type zinc finger 309591 B-Box C-terminal domain 309591 associated with SPRY domains 309591 Domain in SPla and the RYanodine Receptor. 309592 Immunoglobulin C-Type 309595 Forkhead associated domain 309595 breast cancer carboxy-terminal domain 309598 Immunoglobulin C-Type 309599 Immunoglobulin C-Type 309600 Immunoglobulin C-Type 309601 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 309603 Immunoglobulin C-Type 309604 Immunoglobulin C-Type 309605 Immunoglobulin C-Type 309606 Immunoglobulin C-Type 309607 Immunoglobulin C-Type 309613 Broad-Complex, Tramtrack and Bric a brac 309615 Tetratricopeptide repeats 309618 Homeodomain 309619 Immunoglobulin 309619 Domain in SPla and the RYanodine Receptor. 309620 Immunoglobulin 309620 Immunoglobulin V-Type 309620 Domain in SPla and the RYanodine Receptor. 309621 Immunoglobulin C-Type 309622 Immunoglobulin C-Type 309625 Immunoglobulin C-Type 309626 Ring finger 309627 Immunoglobulin C-Type 309628 WD40 repeats 309630 zinc finger 309630 Broad-Complex, Tramtrack and Bric a brac 309639 ankyrin repeats 309640 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 309640 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 309642 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 309647 bromo domain 309647 PHD zinc finger 309647 domain with conserved PWWP motif 309649 ARF-like small GTPases 309649 Rab subfamily of small GTPases 309649 Ras subfamily of RAS small GTPases 309649 Sar1p-like members of the Ras-family of small GTPases 309649 Rho (Ras homology) subfamily of Ras-like small GTPases 309649 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 309650 von Willebrand factor (vWF) type A domain 309650 Protein kinase C conserved region 2 (CalB) 309653 Protein present in Fab1, YOTB, Vac1, and EEA1 309653 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 309653 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 309657 Forkhead associated domain 309665 Scavenger receptor Cys-rich 309665 Trypsin-like serine protease 309665 Low-density lipoprotein receptor domain class A 309666 Src homology 3 domains 309667 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases 309680 Immunoglobulin V-Type 309684 Integrin beta subunits (N-terminal portion of extracellular region) 309694 Src homology 3 domains 309697 Rab subfamily of small GTPases 309697 Ras subfamily of RAS small GTPases 309697 Rho (Ras homology) subfamily of Ras-like small GTPases 309697 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 309715 ankyrin repeats 309722 Rab subfamily of small GTPases 309722 Ras subfamily of RAS small GTPases 309722 Broad-Complex, Tramtrack and Bric a brac 309722 Rho (Ras homology) subfamily of Ras-like small GTPases 309728 ARID (A/T-rich interaction domain) domain 309747 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 309758 Domain Homologous to E6-AP Carboxyl Terminus with 309760 Immunoglobulin 309760 Immunoglobulin C-2 Type 309763 DEAD-like helicases superfamily 309763 helicase superfamily c-terminal domain 309773 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 309774 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 309794 prohibitin homologues 309796 Homeodomain 309804 Tyrosine kinase, catalytic domain 309804 Serine/Threonine protein kinases, catalytic domain 309805 Tyrosine kinase, catalytic domain 309805 Serine/Threonine protein kinases, catalytic domain 309812 DNA polymerase type-B family 309815 C-terminal cystine knot-like domain (CTCK) 309815 Insulin growth factor-binding protein homologues 309822 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 309830 Homeodomain 309831 Homeodomain 309833 Histone 2A 309834 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 309837 Thrombospondin type 1 repeats 309842 K homology RNA-binding domain 309854 WD40 repeats 309858 Domain of unknown function in Sec63p, Brr2p and other proteins 309859 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 309871 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 309887 DEAD-like helicases superfamily 309887 helicase superfamily c-terminal domain 309887 Domain of unknown function in Sec63p, Brr2p and other proteins 309892 ankyrin repeats 309893 snRNP Sm proteins 309895 Immunoglobulin C-Type 309897 Serine/Threonine protein kinases, catalytic domain 309898 Serine/Threonine protein kinases, catalytic domain 309904 Homeodomain 309905 Homeodomain 309906 Homeodomain 309909 c4 zinc finger in nuclear hormone receptors 309922 Broad-Complex, Tramtrack and Bric a brac 309922 Rho (Ras homology) subfamily of Ras-like small GTPases 309928 Protein kinase C conserved region 2 (CalB) 309946 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 309957 MADS domain 309959 G protein gamma subunit-like motifs 309962 PAS domain 309976 B-Box C-terminal domain 309977 Fibronectin type 3 domain 309977 Domain in SPla and the RYanodine Receptor. 309985 ATPase domain of DNA mismatch repair MUTS family 310000 Coagulation factor 5/8 C-terminal domain, discoidin domain 310001 Calcium-binding EGF-like domain 310005 Forkhead associated domain 310009 Calponin homology domain 310019 WD40 repeats 310029 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 310034 ATPases associated with a variety of cellular activities 310068 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 310071 WD40 repeats 310074 Domain found in Dishevelled, Egl-10, and Pleckstrin 310086 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 310090 Fibronectin type 3 domain 310090 DEAD-like helicases superfamily 310090 helicase superfamily c-terminal domain 310091 RNA recognition motif 310096 Laminin G domain 310097 Src homology 3 domains 310097 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 310106 ARF-like small GTPases 310106 Sar1p-like members of the Ras-family of small GTPases 310126 membrane-attack complex / perforin 310126 Domain abundant in complement control proteins 310129 Src homology 3 domains 310132 Fibronectin type 3 domain 310141 Ubiquitin homologues 310144 RNA recognition motif 310160 Ribonuclease III family 310169 high mobility group 310173 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 310174 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 310178 Band 4.1 homologues 310178 Domain in Myosin and Kinesin Tails 310178 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 310180 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 310182 RNA recognition motif 310192 Spectrin repeats 310192 Src homology 3 domains 310192 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 310192 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 310192 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 310200 ankyrin repeats 310209 krueppel associated box 310210 krueppel associated box 310212 Immunoglobulin 310212 Immunoglobulin V-Type 310212 Immunoglobulin C-2 Type 310213 Immunoglobulin 310213 Immunoglobulin V-Type 310213 Immunoglobulin C-2 Type 310214 Immunoglobulin 310214 Immunoglobulin V-Type 310214 Immunoglobulin C-2 Type 310215 Immunoglobulin 310215 Immunoglobulin V-Type 310229 AN1-like Zinc finger 310236 high mobility group 310250 Homeodomain 310257 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 310306 Actin 310306 Ubiquitin associated domain 310306 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 310307 Actin 310314 Ribosomal protein S1-like RNA-binding domain 310317 DnaJ molecular chaperone homology domain 310318 RNA recognition motif 310322 RRM_1 domain 310322 RNA recognition motif 310325 Histone H3 310326 krueppel associated box 310341 Laminin G domain 310341 Calcium-binding EGF-like domain 310341 Epidermal growth factor-like domain 310341 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 310344 Tyrosine kinase, catalytic domain 310344 Serine/Threonine protein kinases, catalytic domain 310348 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function 310352 PHD zinc finger 310353 PHD zinc finger 310358 Phospholipase C, catalytic domain (part) 310363 A Receptor for Ubiquitination Targets 310375 Broad-Complex, Tramtrack and Bric a brac 310376 Tyrosine kinase, catalytic domain 310376 Serine/Threonine protein kinases, catalytic domain 310381 WD40 repeats 310383 Armadillo/beta-catenin-like repeats 310390 GTPase-activator protein for Rho-like GTPases 310401 Rab subfamily of small GTPases 310401 Ras subfamily of RAS small GTPases 310401 Rho (Ras homology) subfamily of Ras-like small GTPases 310426 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 310427 WD40 repeats 310429 minichromosome maintenance proteins 310432 Domain with 2 conserved Trp (W) residues 310433 Ribosomal protein L11/L12 310436 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 310448 Immunoglobulin 310448 Immunoglobulin C-2 Type 310448 Leucine rich repeat C-terminal domain 310460 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 310461 DEAD-like helicases superfamily 310461 helicase superfamily c-terminal domain 310462 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 310463 Phospholipase C, catalytic domain (part) 310463 Protein kinase C conserved region 2 (CalB) 310471 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 310500 Serine/threonine phosphatases, family 2C, catalytic domain 310506 Sigma factor PP2C-like phosphatases 310506 Serine/threonine phosphatases, family 2C, catalytic domain 310511 WD40 repeats 310515 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 310519 Leucine rich repeat C-terminal domain 310531 Histidine kinase-like ATPases 310533 Ras association (RalGDS/AF-6) domain 310533 Cyclic nucleotide-monophosphate binding domain 310533 Guanine nucleotide exchange factor for Ras-like GTPases 310533 Guanine nucleotide exchange factor for Ras-like small GTPases 310533 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 310545 high mobility group 310545 RNA recognition motif 310548 RNA recognition motif 310552 Frizzled 310552 Netrin C-terminal Domain 310553 Toll - interleukin 1 - resistance 310553 Leucine rich repeat C-terminal domain 310565 Trypsin-like serine protease 310579 Annexin repeats 310580 DnaJ molecular chaperone homology domain 310589 meprin and TRAF homology 310589 Broad-Complex, Tramtrack and Bric a brac 310590 Broad-Complex, Tramtrack and Bric a brac 310591 meprin and TRAF homology 310591 Broad-Complex, Tramtrack and Bric a brac 310592 meprin and TRAF homology 310592 Broad-Complex, Tramtrack and Bric a brac 310593 Broad-Complex, Tramtrack and Bric a brac 310594 Broad-Complex, Tramtrack and Bric a brac 310595 meprin and TRAF homology 310595 Broad-Complex, Tramtrack and Bric a brac 310596 meprin and TRAF homology 310596 Broad-Complex, Tramtrack and Bric a brac 310597 Broad-Complex, Tramtrack and Bric a brac 310598 meprin and TRAF homology 310598 Broad-Complex, Tramtrack and Bric a brac 310600 Broad-Complex, Tramtrack and Bric a brac 310601 Broad-Complex, Tramtrack and Bric a brac 310607 DnaJ molecular chaperone homology domain 310609 Domain Homologous to E6-AP Carboxyl Terminus with 310611 Ami_2 domain 310611 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 310612 domain in DSRM or ZnF_C2H2 domain containing proteins 310627 Large family of predicted nucleotide-binding domains 310629 ARF-like small GTPases 310629 Rab subfamily of small GTPases 310629 Ras subfamily of RAS small GTPases 310629 Rho (Ras homology) subfamily of Ras-like small GTPases 310629 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 310630 semaphorin domain 310630 domain found in Plexins, Semaphorins and Integrins 310631 Ring finger 310631 K homology RNA-binding domain 310632 ARF-like small GTPases 310632 Rab subfamily of small GTPases 310632 Ras subfamily of RAS small GTPases 310632 Rho (Ras homology) subfamily of Ras-like small GTPases 310632 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 310633 Ubiquitin associated domain 310635 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 310635 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 310637 Rab subfamily of small GTPases 310637 Ras subfamily of RAS small GTPases 310637 Rho (Ras homology) subfamily of Ras-like small GTPases 310637 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 310638 associated with SET domains 310638 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 310639 Src homology 3 domains 310639 domain involved in Ras-like GTPase signaling 310641 B-Box-type zinc finger 310641 B-Box C-terminal domain 310641 Fibronectin type 3 domain 310641 Domain in SPla and the RYanodine Receptor. 310647 Src homology 2 domains 310650 meprin and TRAF homology 310650 Broad-Complex, Tramtrack and Bric a brac 310651 Ligand binding domain of hormone receptors 310651 Protein kinase C conserved region 2 (CalB) 310651 c4 zinc finger in nuclear hormone receptors 310652 Tudor domain 310652 K homology RNA-binding domain 310654 RNA recognition motif 310657 high mobility group 310658 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 310664 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 310666 Annexin repeats 310667 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 310668 Methyl-CpG binding domain 310668 N-terminal to some SET domains 310668 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 310674 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 310677 A20-like zinc fingers 310678 Histone H3 310679 Histone H3 310683 von Willebrand factor (vWF) type A domain 310683 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 310688 Src homology 2 domains 310691 erythroblast transformation specific domain 310693 Immunoglobulin 310693 Scavenger receptor Cys-rich 310694 Immunoglobulin 310694 Immunoglobulin C-2 Type 310694 Scavenger receptor Cys-rich 310697 Domain in the Doublecortin (DCX) gene product 310698 Tyrosine kinase, catalytic domain 310698 Serine/Threonine protein kinases, catalytic domain 310707 DEAD-like helicases superfamily 310713 Histone H3 310720 WD40 repeats 310727 Immunoglobulin 310727 Immunoglobulin V-Type 310738 Nerve growth factor (NGF or beta-NGF) 310740 Cold shock protein domain 310741 catalytic domain of ctd-like phosphatases 310743 Olfactomedin-like domains 310753 Immunoglobulin 310753 Immunoglobulin C-2 Type 310753 Leucine rich repeat C-terminal domain 310756 DEAD-like helicases superfamily 310756 ATPases associated with a variety of cellular activities 310769 WD40 repeats 310771 Glyco_18 domain 310781 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 310782 Immunoglobulin 310782 Immunoglobulin C-2 Type 310782 Fibronectin type 3 domain 310785 C-terminal to LisH motif. 310787 Fibronectin type 3 domain 310797 Alpha-amylase domain 310810 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at present 310810 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 310812 Acid phosphatase homologues 310815 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 310819 RNA recognition motif 310820 RNA recognition motif 310826 high mobility group 310833 GTPase-activator protein for Rho-like GTPases 310833 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 310838 Src homology 2 domains 310838 Guanine nucleotide exchange factor for Ras-like small GTPases 310839 Src homology 3 domains 310839 Fes/CIP4 homology domain 310842 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 310846 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 310869 Immunoglobulin 310869 Immunoglobulin C-2 Type 310898 Src homology 2 domains 310900 Lipoprotein N-terminal Domain 310900 Thymosin beta actin-binding motif 310909 Armadillo/beta-catenin-like repeats 310914 Tyrosine kinase, catalytic domain 310914 Serine/Threonine protein kinases, catalytic domain 310922 RNA recognition motif 310923 WD40 repeats 310932 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 310945 RNA recognition motif 310958 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 310960 Domain in ubiquitin-specific proteases 310964 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 310986 Tyrosine kinase, catalytic domain 310986 Serine/Threonine protein kinases, catalytic domain 310987 Extension to Ser/Thr-type protein kinases 310996 helix loop helix domain 310999 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 310999 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 310999 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 311003 meprin and TRAF homology 311003 Broad-Complex, Tramtrack and Bric a brac 311004 meprin and TRAF homology 311005 meprin and TRAF homology 311005 Broad-Complex, Tramtrack and Bric a brac 311006 meprin and TRAF homology 311006 Broad-Complex, Tramtrack and Bric a brac 311009 Ring finger 311020 RNA recognition motif 311030 Src homology 3 domains 311030 Domain present in VPS-27, Hrs and STAM 311033 Formin Homology 2 Domain 311047 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 311055 ankyrin repeats 311058 ARF-like small GTPases 311060 Ricin-type beta-trefoil 311060 Fibronectin type 2 domain 311060 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 311061 Integrin beta subunits (N-terminal portion of extracellular region) 311082 DEAD-like helicases superfamily 311082 helicase superfamily c-terminal domain 311105 DnaJ molecular chaperone homology domain 311110 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 311111 Src homology 3 domains 311114 Kelch domain 311114 Broad-Complex, Tramtrack and Bric a brac 311115 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 311130 Double-stranded RNA binding motif 311132 Immunoglobulin 311132 Immunoglobulin C-2 Type 311137 U1-like zinc finger 311144 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 311147 G protein alpha subunit 311151 Dual specificity phosphatase, catalytic domain 311151 Protein tyrosine phosphatase, catalytic domain motif 311166 ATPases associated with a variety of cellular activities 311167 Calponin homology domain 311169 Leucine rich repeat C-terminal domain 311171 Leucine rich repeat N-terminal domain 311183 Zn_pept domain 311183 Domain with 2 conserved Trp (W) residues 311184 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 311185 Broad-Complex, Tramtrack and Bric a brac 311187 Src homology 3 domains 311187 Fes/CIP4 homology domain 311190 Low molecular weight phosphatase family 311193 GTPase-activator protein for Rho-like GTPases 311193 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 311197 high mobility group 311236 Immunoglobulin 311236 Immunoglobulin C-2 Type 311236 Leucine rich repeat C-terminal domain 311245 Ring finger 311245 meprin and TRAF homology 311245 Modified RING finger domain 311250 B-Box-type zinc finger 311252 Trypsin-like serine protease 311252 Domain abundant in complement control proteins 311252 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 311260 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 311289 JAB/MPN domain 311310 Homeodomain 311322 ankyrin repeats 311329 DnaJ molecular chaperone homology domain 311330 Protein present in Fab1, YOTB, Vac1, and EEA1 311331 Low-density lipoprotein receptor domain class A 311331 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 311332 delta serrate ligand 311332 Calcium-binding EGF-like domain 311334 3'-5' exonuclease 311337 Tyrosine kinase, catalytic domain 311337 Serine/Threonine protein kinases, catalytic domain 311340 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 311341 Protein kinase C conserved region 2 (CalB) 311341 Cytoplasmic phospholipase A2, catalytic subunit 311342 Protein kinase C conserved region 2 (CalB) 311342 Cytoplasmic phospholipase A2, catalytic subunit 311342 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 311343 Protein kinase C conserved region 2 (CalB) 311343 Cytoplasmic phospholipase A2, catalytic subunit 311354 leucine rich region 311362 Band 4.1 homologues 311368 catalytic domain of ctd-like phosphatases 311373 Ring finger 311373 associated with SPRY domains 311373 Domain in SPla and the RYanodine Receptor. 311375 Src homology 2 domains 311384 semaphorin domain 311384 domain found in Plexins, Semaphorins and Integrins 311391 Src homology 2 domains 311391 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 311406 Protein tyrosine phosphatase, catalytic domain 311406 Dual specificity phosphatase, catalytic domain 311406 Protein tyrosine phosphatase, catalytic domain motif 311415 zinc finger 311419 Tyrosine kinase, catalytic domain 311419 Serine/Threonine protein kinases, catalytic domain 311425 ADAM Cysteine-Rich Domain 311426 Immunoglobulin 311426 Immunoglobulin C-Type 311426 Immunoglobulin C-2 Type 311431 RNA recognition motif 311437 Ras association (RalGDS/AF-6) domain 311443 Fibronectin type 3 domain 311450 Tyrosine kinase, catalytic domain 311450 Serine/Threonine protein kinases, catalytic domain 311451 P21-Rho-binding domain 311462 Broad-Complex, Tramtrack and Bric a brac 311464 K homology RNA-binding domain 311470 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 311474 Appr-1"-p processing enzyme 311478 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 311480 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 311503 Homeodomain 311505 Paired Box domain 311508 Broad-Complex, Tramtrack and Bric a brac 311510 krueppel associated box 311511 Cystatin-like domain 311512 Cystatin-like domain 311513 Cystatin-like domain 311514 Cystatin-like domain 311515 Cystatin-like domain 311517 Histone H3 311519 Histone H3 311523 krueppel associated box 311525 Putative GTP-ase activating proteins for the small GTPase, ARF 311526 krueppel associated box 311527 BCL (B-Cell lymphoma) 311527 Tyrosine kinase, catalytic domain 311527 Serine/Threonine protein kinases, catalytic domain 311532 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 311538 high mobility group 311542 Rab subfamily of small GTPases 311542 Ras subfamily of RAS small GTPases 311542 Rho (Ras homology) subfamily of Ras-like small GTPases 311544 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 311547 FORKHEAD 311547 interferon regulatory factor 311547 Dual specificity phosphatase, catalytic domain 311547 Protein tyrosine phosphatase, catalytic domain motif 311557 domain with conserved PWWP motif 311558 BPI/LBP/CETP C-terminal domain 311558 BPI/LBP/CETP N-terminal domain 311560 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 311566 Ribosomal protein L11/L12 311567 Domain with 2 conserved Trp (W) residues 311567 Protein kinase C conserved region 2 (CalB) 311570 Myosin. Large ATPases. ATPase 311575 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 311577 Src homology 3 domains 311577 Src homology 2 domains 311579 domain in TBC and LysM domain containing proteins 311580 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) 311591 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 311593 RNA recognition motif 311597 Actin 311604 Homeodomain 311607 DEAD-like helicases superfamily 311607 Chromatin organization modifier domain 311607 helicase superfamily c-terminal domain 311609 Fibronectin type 3 domain 311612 RNA recognition motif 311613 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 311614 Helical region found in SNAREs 311614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis 311615 high mobility group 311618 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 311621 Tetratricopeptide repeats 311622 Tyrosine kinase, catalytic domain 311622 Serine/Threonine protein kinases, catalytic domain 311626 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 311627 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 311629 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 311633 domain in neuralized proteins 311635 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR 311639 krueppel associated box 311647 Domain found in Dishevelled, Egl-10, and Pleckstrin 311647 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 311647 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 311647 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 311655 Rhodanese Homology Domain 311667 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 311670 WD40 repeats 311672 Helical region found in SNAREs 311674 Rab subfamily of small GTPases 311674 Ras subfamily of RAS small GTPases 311674 Rho (Ras homology) subfamily of Ras-like small GTPases 311674 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 311675 ARF-like small GTPases 311675 Rab subfamily of small GTPases 311675 Ras subfamily of RAS small GTPases 311675 Rho (Ras homology) subfamily of Ras-like small GTPases 311675 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 311681 krueppel associated box 311685 krueppel associated box 311688 krueppel associated box 311689 Endothelin 311693 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 311701 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 311715 PHD zinc finger 311715 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 311716 Fibronectin type 3 domain 311716 von Willebrand factor (vWF) type A domain 311716 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 311721 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 311723 high mobility group 311727 krueppel associated box 311727 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 311730 Domain found in Dishevelled, Egl-10, and Pleckstrin 311738 zinc finger 311745 Cyclic nucleotide-monophosphate binding domain 311756 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 311759 Thrombospondin type 1 repeats 311761 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 311765 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 311767 krueppel associated box 311768 krueppel associated box 311771 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 311772 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 311775 GTPase-activator protein for Rho-like GTPases 311776 RNA recognition motif 311783 Interleukin-1 homologues 311784 Interleukin-1 homologues 311785 Sec7 domain 311785 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 311793 Src homology 3 domains 311794 ankyrin repeats 311799 Ring finger 311803 Leucine rich repeat C-terminal domain 311821 Phosphate acyltransferases 311825 Tyrosine kinase, catalytic domain 311825 Serine/Threonine protein kinases, catalytic domain 311826 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 311827 Thrombospondin type 1 repeats 311848 BAR domain 311856 Domain in ubiquitin-specific proteases 311856 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 311858 G2 nidogen domain and fibulin 311858 Calcium-binding EGF-like domain 311858 Epidermal growth factor-like domain 311860 Src homology 3 domains 311860 Src homology 2 domains 311860 Tyrosine kinase, catalytic domain 311860 Serine/Threonine protein kinases, catalytic domain 311861 Fibrinogen-related domains (FReDs) 311862 Laminin B domain 311862 Laminin N-terminal domain (domain VI) 311862 Laminin-type epidermal growth factor-like domai 311870 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 311872 Broad-Complex, Tramtrack and Bric a brac 311876 Homeodomain 311880 Domain present in VPS9 311880 GTPase-activator protein for Ras-like GTPases 311881 WD40 repeats 311885 Anaphylatoxin homologous domain 311901 Homeodomain 311901 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 311902 RNA recognition motif 311905 Ubiquitin homologues 311906 Ubiquitin homologues 311907 Ubiquitin homologues 311909 Ring finger 311910 Broad-Complex, Tramtrack and Bric a brac 311911 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 311917 Tyrosine kinase, catalytic domain 311917 Serine/Threonine protein kinases, catalytic domain 311926 Low-density lipoprotein-receptor YWTD domain 311926 Low-density lipoprotein receptor domain class A 311929 Low-density lipoprotein receptor domain class A 311933 Ly-6 antigen / uPA receptor -like domain 311936 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 311942 Homeodomain 311944 high mobility group 311944 breast cancer carboxy-terminal domain 311952 Ricin-type beta-trefoil 311955 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 311956 WD40 repeats 311968 PHD zinc finger 311968 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 311977 ARF-like small GTPases 311977 G protein alpha subunit 311977 Rab subfamily of small GTPases 311977 Sar1p-like members of the Ras-family of small GTPases 311995 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 312000 Myosin. Large ATPases. ATPase 312008 Myosin. Large ATPases. ATPase 312009 Myosin. Large ATPases. ATPase 312015 Myosin. Large ATPases. ATPase 312021 Myosin. Large ATPases. ATPase 312024 Myosin. Large ATPases. ATPase 312030 Ring finger 312032 semaphorin domain 312046 Zinc finger in DBF-like proteins 312051 RNA recognition motif 312068 In Between Ring fingers 312069 Serine/Threonine protein kinases, catalytic domain 312071 Tyrosine kinase, catalytic domain 312071 Serine/Threonine protein kinases, catalytic domain 312075 Tyrosine kinase, catalytic domain 312075 Serine/Threonine protein kinases, catalytic domain 312076 RNA recognition motif 312078 BCL (B-Cell lymphoma) 312096 Homeodomain 312102 Immunoglobulin 312102 Immunoglobulin V-Type 312108 GTPase-activator protein for Rho-like GTPases 312113 GTPase-activator protein for Rho-like GTPases 312113 in StAR and phosphatidylcholine transfer protein 312115 von Willebrand factor (vWF) type A domain 312115 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 312120 S4 RNA-binding domain 312127 Thrombospondin type 1 repeats 312136 RNA recognition motif 312140 FORKHEAD 312142 RRM_1 domain 312142 RNA recognition motif 312148 found in Wnt-1 312149 found in Wnt-1 312150 ATPases associated with a variety of cellular activities 312152 RNA recognition motif 312152 Suppressor-of-White-APricot splicing regulator 312152 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 312157 found in Wnt-1 312167 Ring finger 312178 Histone H3 312182 RNA recognition motif 312199 Kelch domain 312201 Zn_pept domain 312202 Rhodanese Homology Domain 312210 ig-like, plexins, transcription factors 312210 domain found in Plexins, Semaphorins and Integrins 312212 semaphorin domain 312213 semaphorin domain 312217 high mobility group 312224 Zn_pept domain 312225 WD40 repeats 312227 RRM_1 domain 312227 RNA recognition motif 312240 high mobility group 312243 bromo domain 312243 B-Box C-terminal domain 312256 ARF-like small GTPases 312256 Rab subfamily of small GTPases 312256 Ras subfamily of RAS small GTPases 312256 Rho (Ras homology) subfamily of Ras-like small GTPases 312256 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 312261 Thymosin beta actin-binding motif 312262 Tyrosine kinase, catalytic domain 312262 Serine/Threonine protein kinases, catalytic domain 312263 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 312269 Diacylglycerol kinase catalytic domain (presumed) 312273 Trypsin-like serine protease 312274 Immunoglobulin 312275 Fibronectin type 3 domain 312275 Tyrosine kinase, catalytic domain 312275 Ephrin receptor ligand binding domain 312275 Serine/Threonine protein kinases, catalytic domain 312275 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 312279 Fibronectin type 3 domain 312279 Tyrosine kinase, catalytic domain 312279 Ephrin receptor ligand binding domain 312279 Serine/Threonine protein kinases, catalytic domain 312279 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 312291 Laminin G domain 312292 Laminin G domain 312296 putative band 4.1 homologues' binding motif 312299 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 312302 krueppel associated box 312303 zinc finger 312303 krueppel associated box 312314 GTPase-activator protein for Ras-like GTPases 312320 RNA recognition motif 312320 K homology RNA-binding domain 312321 RNA recognition motif 312325 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 312331 basic region leucin zipper 312335 Homeodomain 312336 Homeodomain 312337 Homeodomain 312338 Homeodomain 312339 Homeodomain 312346 RNA recognition motif 312350 basic region leucin zipper 312357 Src homology 2 domains 312361 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 312363 Ribosomal protein L11/L12 312370 snRNP Sm proteins 312372 Kelch domain 312374 RNA recognition motif 312381 Serine/threonine phosphatases, family 2C, catalytic domain 312387 putative band 4.1 homologues' binding motif 312391 Calcium-binding EGF-like domain 312391 Epidermal growth factor-like domain 312391 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 312398 DEAD-like helicases superfamily 312398 helicase superfamily c-terminal domain 312403 high mobility group 312407 Fibronectin type 3 domain 312408 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin 312409 Immunoglobulin 312409 Immunoglobulin V-Type 312411 Immunoglobulin 312411 Immunoglobulin V-Type 312412 Immunoglobulin 312412 Immunoglobulin V-Type 312413 Immunoglobulin 312413 Immunoglobulin V-Type 312414 Immunoglobulin 312414 Immunoglobulin V-Type 312415 Immunoglobulin 312415 Immunoglobulin V-Type 312415 Immunoglobulin C-2 Type 312416 Immunoglobulin 312416 Immunoglobulin V-Type 312416 Immunoglobulin C-2 Type 312418 Immunoglobulin 312418 Immunoglobulin V-Type 312419 Immunoglobulin 312419 Immunoglobulin V-Type 312420 Immunoglobulin 312420 Immunoglobulin V-Type 312420 Immunoglobulin C-2 Type 312421 Immunoglobulin 312421 Immunoglobulin V-Type 312422 Immunoglobulin V-Type 312423 Immunoglobulin 312423 Immunoglobulin V-Type 312424 Immunoglobulin 312424 Immunoglobulin V-Type 312425 Immunoglobulin V-Type 312425 krueppel associated box 312426 Immunoglobulin 312426 Immunoglobulin V-Type 312428 Immunoglobulin 312428 Immunoglobulin V-Type 312429 Immunoglobulin 312429 Immunoglobulin V-Type 312430 Immunoglobulin 312430 Immunoglobulin V-Type 312432 Immunoglobulin C-Type 312435 Ras subfamily of RAS small GTPases 312436 Low molecular weight phosphatase family 312439 C-terminal to LisH motif. 312439 Lissencephaly type-1-like homology motif 312451 high mobility group 312477 Phosphotyrosine-binding domain (IRS1-like) 312478 Scavenger receptor Cys-rich 312479 Homeodomain 312480 Ring finger 312489 ankyrin repeats 312492 Protein kinase C conserved region 2 (CalB) 312492 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the 312501 Serine/Threonine protein kinases, catalytic domain 312502 Protein kinase C conserved region 2 (CalB) 312503 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 312507 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 312510 RRM_1 domain 312510 RNA recognition motif 312516 Broad-Complex, Tramtrack and Bric a brac 312519 Tyrosine kinase, catalytic domain 312519 Serine/Threonine protein kinases, catalytic domain 312522 GTPase-activator protein for Rho-like GTPases 312526 Leucine rich repeat C-terminal domain 312529 Domain in histone families 1 and 5 312530 DnaJ molecular chaperone homology domain 312535 Kelch domain 312535 Broad-Complex, Tramtrack and Bric a brac 312536 ankyrin repeats 312536 Broad-Complex, Tramtrack and Bric a brac 312538 minichromosome maintenance proteins 312538 ATPases associated with a variety of cellular activities 312545 K homology RNA-binding domain 312548 GTPase-activator protein for Rho-like GTPases 312549 GTPase-activator protein for Rho-like GTPases 312552 Sec7 domain 312552 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 312558 found in Wnt-1 312563 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 312565 Thrombospondin type 1 repeats 312566 Thrombospondin type 1 repeats 312574 Immunoglobulin 312574 Immunoglobulin C-2 Type 312575 RNA recognition motif 312589 helix loop helix domain 312607 Calponin homology domain 312607 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 312617 Immunoglobulin 312617 Immunoglobulin C-2 Type 312617 Leucine rich repeat C-terminal domain 312622 N-terminal to some SET domains 312622 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 312636 Domains present in proteins implicated in post-mortem DNA fragmentation 312638 Calcium-binding EGF-like domain 312651 WD40 repeats 312652 semaphorin domain 312652 ig-like, plexins, transcription factors 312652 domain found in Plexins, Semaphorins and Integrins 312659 Ras association (RalGDS/AF-6) domain 312663 Histone 2A 312664 Guanine nucleotide exchange factor for Ras-like GTPases 312664 Guanine nucleotide exchange factor for Ras-like small GTPases 312666 krueppel associated box 312667 ankyrin repeats 312667 krueppel associated box 312668 von Willebrand factor (vWF) type A domain 312672 Leucine rich repeat N-terminal domain 312674 found in Wnt-1 312678 PHD zinc finger 312681 bromo domain 312687 Sec7 domain 312690 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 312696 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312698 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312700 Trypsin-like serine protease 312700 Domain abundant in complement control proteins 312700 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 312701 Scavenger receptor Cys-rich 312710 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 312714 von Willebrand factor (vWF) type D domain 312721 Tyrosine kinase, catalytic domain 312721 Serine/Threonine protein kinases, catalytic domain 312742 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312744 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312745 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312748 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312750 Chromo Shadow Domain 312750 Chromatin organization modifier domain 312752 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312753 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312756 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312758 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312759 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312760 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312761 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312762 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312763 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312777 SAM / Pointed domain 312777 erythroblast transformation specific domain 312782 Low-density lipoprotein-receptor YWTD domain 312803 Histone H4 312804 Histone 2A 312811 prohibitin homologues 312812 Src homology 3 domains 312812 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 312818 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 312824 DEAD-like helicases superfamily 312824 helicase superfamily c-terminal domain 312828 ZnF_C4 abd HLH domain containing kinases domain 312850 Tyrosine kinase, catalytic domain 312850 Extension to Ser/Thr-type protein kinases 312850 Serine/Threonine protein kinases, catalytic domain 312851 helix loop helix domain 312855 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 312858 Kelch domain 312858 Broad-Complex, Tramtrack and Bric a brac 312860 Kelch domain 312866 S4 RNA-binding domain 312872 Domain with 2 conserved Trp (W) residues 312874 Myosin. Large ATPases. ATPase 312879 Immunoglobulin 312879 Immunoglobulin V-Type 312879 Immunoglobulin C-2 Type 312882 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine 312884 Homeodomain 312885 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 312887 ankyrin repeats 312896 ankyrin repeats 312897 helix loop helix domain 312903 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 312907 Kazal type serine protease inhibitors 312912 Domain found in Dishevelled, Egl-10, and Pleckstrin 312912 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 312912 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 312913 Zn_pept domain 312915 Sec7 domain 312916 JAB/MPN domain 312917 helix loop helix domain 312921 RNA recognition motif 312923 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 312923 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 312932 C2C2 Zinc finger 312932 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 312932 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 312936 high mobility group 312937 Domain in the Doublecortin (DCX) gene product 312938 Lipoxygenase homology 2 (beta barrel) domain 312939 Lipoxygenase homology 2 (beta barrel) domain 312940 Lipoxygenase homology 2 (beta barrel) domain 312946 Phosphate acyltransferases 312947 Ribosomal RNA adenine dimethylases 312949 FORKHEAD 312959 Double-stranded RNA binding motif 312959 glycine rich nucleic binding domain 312964 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 312965 Domain present in ubiquitin-regulatory proteins 312965 Domain of unknown function present in FAF1 (Fas-associated factor 1) 312967 WD40 repeats 312967 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 312974 DEAD-like helicases superfamily 312974 Chromatin organization modifier domain 312974 helicase superfamily c-terminal domain 312974 domain in transcription and CHROMO domain helicases 312980 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 312994 RRM_1 domain 312994 RNA recognition motif 312999 Laminin G domain 312999 Coagulation factor 5/8 C-terminal domain, discoidin domain 313011 DEAD-like helicases superfamily 313011 helicase superfamily c-terminal domain 313017 14-3-3 homologues 313020 WD40 repeats 313030 Forkhead associated domain 313035 DnaJ molecular chaperone homology domain 313038 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 313039 zinc finger 313039 leucine rich region 313041 high mobility group 313045 B-Box C-terminal domain 313045 associated with SPRY domains 313045 Domain in SPla and the RYanodine Receptor. 313048 WD40 repeats 313049 Broad-Complex, Tramtrack and Bric a brac 313050 Src homology 2 domains 313050 Src homology 3 domains 313050 Tyrosine kinase, catalytic domain 313050 Serine/Threonine protein kinases, catalytic domain 313051 RNA recognition motif 313052 Band 4.1 homologues 313056 WD40 repeats 313058 Thrombospondin type 1 repeats 313058 Domain present in hormone receptors 313058 G-protein-coupled receptor proteolytic site domain 313060 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 313063 DEAD-like helicases superfamily 313063 helicase superfamily c-terminal domain 313069 RNA recognition motif 313070 RNA recognition motif 313087 von Willebrand factor (vWF) type A domain 313087 Protein kinase C conserved region 2 (CalB) 313099 domain present in cyclins, TFIIB and Retinoblastoma 313101 Leucine-rich repeat - CC (cysteine-containing) subfamily 313111 Kelch domain 313112 Broad-Complex, Tramtrack and Bric a brac 313121 Tyrosine kinase, catalytic domain 313121 Serine/Threonine protein kinases, catalytic domain 313125 basic region leucin zipper 313126 Connexin homologues 313129 ankyrin repeats 313131 Dual specificity phosphatase, catalytic domain 313132 DEAD-like helicases superfamily 313152 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 313156 Immunoglobulin 313156 Immunoglobulin C-2 Type 313156 Leucine rich repeat C-terminal domain 313163 ARF-like small GTPases 313163 Rab subfamily of small GTPases 313163 Ras subfamily of RAS small GTPases 313163 Rho (Ras homology) subfamily of Ras-like small GTPases 313163 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 313166 Putative single-stranded nucleic acids-binding domain 313168 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 313169 Ubiquitin associated domain 313170 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 313171 WD40 repeats 313184 Band 4.1 homologues 313191 Domain abundant in complement control proteins 313192 von Willebrand factor (vWF) type A domain 313208 Fibronectin type 3 domain 313208 Domain in SPla and the RYanodine Receptor. 313216 Ring finger 313219 krueppel associated box 313228 ankyrin repeats 313233 Ricin-type beta-trefoil 313234 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 313234 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313235 WD40 repeats 313236 B-Box-type zinc finger 313236 associated with SPRY domains 313236 Domain in SPla and the RYanodine Receptor. 313240 Src homology 2 domains 313242 WD40 repeats 313244 Band 4.1 homologues 313244 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313254 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 313255 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313255 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313256 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313258 krueppel associated box 313263 membrane-attack complex / perforin 313264 Ring finger 313264 B-Box-type zinc finger 313265 membrane-attack complex / perforin 313270 Laminin-type epidermal growth factor-like domai 313273 bromo domain 313276 Extension to Ser/Thr-type protein kinases 313276 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 313278 Immunoglobulin 313278 Immunoglobulin C-2 Type 313278 Fibronectin type 3 domain 313278 Protein tyrosine phosphatase, catalytic domain 313279 Immunoglobulin 313279 Immunoglobulin C-2 Type 313296 WD40 repeats 313297 high mobility group 313303 Src homology 2 domains 313309 Tyrosine kinase, catalytic domain 313313 high mobility group 313322 C-terminal cystine knot-like domain (CTCK) 313322 Domains in Na-Ca exchangers and integrin-beta4 313322 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 313323 domain with conserved PWWP motif 313331 Found in Skp1 protein family 313332 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 313348 Kelch domain 313348 Broad-Complex, Tramtrack and Bric a brac 313352 Doublesex DNA-binding motif 313355 RNA recognition motif 313357 RNA recognition motif 313364 Leucine rich repeat C-terminal domain 313382 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313383 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313386 Domain in ubiquitin-specific proteases 313389 Fibrinogen-related domains (FReDs) 313399 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 313409 DnaJ molecular chaperone homology domain 313416 WD40 repeats 313418 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 313421 Thrombospondin type 1 repeats 313421 membrane-attack complex / perforin 313438 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313445 Kelch domain 313450 Ring finger 313450 zinc finger 313451 Homeodomain 313452 Homeodomain 313454 Broad-Complex, Tramtrack and Bric a brac 313455 Homeodomain 313467 RNA recognition motif 313471 Doublesex DNA-binding motif 313473 Ring finger 313474 Eps15 homology domain 313475 Eps15 homology domain 313477 Protein present in Fab1, YOTB, Vac1, and EEA1 313478 Protein kinase C conserved region 2 (CalB) 313478 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 313479 Bromo adjacent homology domain 313479 Bromo adjacent homology domain 313484 Doublesex DNA-binding motif 313485 Immunoglobulin 313485 Immunoglobulin V-Type 313487 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 313498 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 313499 ankyrin repeats 313504 FORKHEAD 313505 FORKHEAD 313507 helix loop helix domain 313511 Tyrosine kinase, catalytic domain 313511 Serine/Threonine protein kinases, catalytic domain 313512 Homeodomain 313518 Kelch domain 313525 Domain Homologous to E6-AP Carboxyl Terminus with 313526 Broad-Complex, Tramtrack and Bric a brac 313533 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 313539 Tudor domain 313539 PHD zinc finger 313539 Small domain found in the jumonji family of transcription factors 313539 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 313540 RIO-like kinase 313540 Tyrosine kinase, catalytic domain 313540 Serine/Threonine protein kinases, catalytic domain 313543 Tyrosine kinase, catalytic domain 313543 Serine/Threonine protein kinases, catalytic domain 313547 Ubiquitin homologues 313558 FORKHEAD 313566 Histone H3 313568 Actin depolymerisation factor/cofilin -like domains 313575 Orange domain 313575 helix loop helix domain 313576 Transforming growth factor-beta (TGF-beta) family 313577 Calponin homology domain 313582 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 313588 Forkhead associated domain 313592 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 313609 Tyrosine kinase, catalytic domain 313609 Serine/Threonine protein kinases, catalytic domain 313625 Immunoglobulin 313625 Immunoglobulin C-2 Type 313625 Fibronectin type 3 domain 313626 RNA recognition motif 313629 RNA recognition motif 313631 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 313633 Fibronectin type 3 domain 313633 Tyrosine kinase, catalytic domain 313633 Serine/Threonine protein kinases, catalytic domain 313633 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 313635 Ephrin receptor ligand binding domain 313636 Ephrin receptor ligand binding domain 313637 Broad-Complex, Tramtrack and Bric a brac 313641 Immunoglobulin 313641 Laminin G domain 313641 Immunoglobulin C-2 Type 313642 Low-density lipoprotein receptor domain class A 313647 Domain in histone families 1 and 5 313650 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 313652 Ribosomal protein L11/L12 313653 von Willebrand factor (vWF) type A domain 313658 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 313659 Homeodomain 313659 Paired Box domain 313666 Broad-Complex, Tramtrack and Bric a brac 313667 domain involved in Ras-like GTPase signaling 313667 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313670 Forkhead associated domain 313672 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 313679 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 313681 Leucine rich repeat N-terminal domain 313685 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 313692 krueppel associated box 313694 krueppel associated box 313697 krueppel associated box 313698 krueppel associated box 313707 3'-5' exonuclease 313707 Helicase and RNase D C-terminal 313722 suppressors of cytokine signalling 313722 Domain in SPla and the RYanodine Receptor. 313742 PHD zinc finger 313742 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 313743 Kelch domain 313743 Broad-Complex, Tramtrack and Bric a brac 313745 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 313745 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 313745 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313756 Phospholipase C, catalytic domain (part) 313756 Protein kinase C conserved region 2 (CalB) 313770 Immunoglobulin V-Type 313772 BAR domain 313772 Putative GTP-ase activating proteins for the small GTPase, ARF 313772 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313778 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 313780 krueppel associated box 313782 A Receptor for Ubiquitination Targets 313783 Olfactomedin-like domains 313785 Immunoglobulin 313785 Immunoglobulin C-2 Type 313787 high mobility group 313800 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 313804 leucine rich region 313806 In Between Ring fingers 313811 DnaJ molecular chaperone homology domain 313817 minichromosome maintenance proteins 313819 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 313820 Tyrosine kinase, catalytic domain 313820 Serine/Threonine protein kinases, catalytic domain 313823 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 313827 Histone H3 313830 von Willebrand factor (vWF) type A domain 313831 von Willebrand factor (vWF) type A domain 313834 Tyrosine kinase, catalytic domain 313834 Serine/Threonine protein kinases, catalytic domain 313834 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313838 P21-Rho-binding domain 313842 RNA recognition motif 313844 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 313845 Guanine nucleotide exchange factor for Ras-like GTPases 313845 Guanine nucleotide exchange factor for Ras-like small GTPases 313845 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313846 Histone 2A 313846 Guanine nucleotide exchange factor for Ras-like small GTPases 313847 Tyrosine kinase, catalytic domain 313847 Serine/Threonine protein kinases, catalytic domain 313860 Tyrosine kinase, catalytic domain 313860 Serine/Threonine protein kinases, catalytic domain 313861 WD40 repeats 313866 Band 4.1 homologues 313866 Domain in Myosin and Kinesin Tails 313866 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313874 Guanine nucleotide exchange factor for Ras-like GTPases 313874 Guanine nucleotide exchange factor for Ras-like small GTPases 313874 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 313878 Ricin-type beta-trefoil 313879 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 313880 calpain_III domain 313881 Phosphate acyltransferases 313890 Tyrosine kinase, catalytic domain 313901 high mobility group 313905 Bromodomain transcription factors and PHD domain containing proteins 313910 Tyrosine kinase, catalytic domain 313910 Serine/Threonine protein kinases, catalytic domain 313925 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 313927 domain with conserved PWWP motif 313934 Eps15 homology domain 313935 Protein kinase C conserved region 2 (CalB) 313935 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 313935 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 313939 ATPases associated with a variety of cellular activities 313940 bromo domain 313950 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 313954 von Willebrand factor (vWF) type A domain 313957 RNA recognition motif 313960 helix loop helix domain 313974 Tyrosine kinase, catalytic domain 313974 Serine/Threonine protein kinases, catalytic domain 313986 high mobility group 313987 RNA recognition motif 313991 RNA recognition motif 314010 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 314014 WD40 repeats 314016 von Willebrand factor (vWF) type C domain 314032 EF-hand, calcium binding motif 314046 ankyrin repeats 314050 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 314063 Histone H3 314092 Tyrosine kinase, catalytic domain 314092 Serine/Threonine protein kinases, catalytic domain 314095 von Willebrand factor (vWF) type A domain 314099 Src homology 2 domains 314099 Protein tyrosine phosphatase, catalytic domain motif 314099 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 314108 snRNP Sm proteins 314111 Broad-Complex, Tramtrack and Bric a brac 314113 Kelch domain 314117 Histidine kinase-like ATPases 314121 RNA recognition motif 314125 Actin depolymerisation factor/cofilin -like domains 314126 bromo domain 314126 PHD zinc finger 314126 domain in different transcription and chromosome remodeling factors 314132 high mobility group 314138 Paired Box domain 314148 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 314151 DEAD-like helicases superfamily 314151 helicase superfamily c-terminal domain 314157 A Receptor for Ubiquitination Targets 314164 Immunoglobulin 314164 Immunoglobulin C-2 Type 314166 high mobility group 314173 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 314174 Ubiquitin homologues 314176 Histone 2A 314180 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 314182 Immunoglobulin 314182 Immunoglobulin C-2 Type 314193 Tyrosine kinase, catalytic domain 314193 Serine/Threonine protein kinases, catalytic domain 314194 Tyrosine kinase, catalytic domain 314194 Serine/Threonine protein kinases, catalytic domain 314195 Guanine nucleotide exchange factor for Ras-like small GTPases 314198 Tyrosine kinase, catalytic domain 314198 Serine/Threonine protein kinases, catalytic domain 314205 Chromatin organization modifier domain 314212 Formin Homology 2 Domain 314221 Homeodomain 314225 Protein kinase C conserved region 2 (CalB) 314242 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 314245 Broad-Complex, Tramtrack and Bric a brac 314246 Broad-Complex, Tramtrack and Bric a brac 314249 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 314249 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314250 Spectrin repeats 314250 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314254 Src homology 3 domains 314259 Src homology 3 domains 314259 domain in receptor targeting proteins Lin-2 and Lin-7 314259 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 314259 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 314260 Domain found in Dishevelled, Egl-10, and Pleckstrin 314260 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314261 Helical region found in SNAREs 314262 Band 4.1 homologues 314262 Domain in Myosin and Kinesin Tails 314262 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314273 WD40 repeats 314283 ADAM Cysteine-Rich Domain 314283 Homologues of snake disintegrins 314284 Tetratricopeptide repeats 314296 domain in splicing factors 314297 Immunoglobulin 314297 Immunoglobulin C-2 Type 314306 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 314313 Ring finger 314313 zinc finger 314317 snRNP Sm proteins 314317 domain present in translation initiation factor eIF2B and eIF5 314322 basic region leucin zipper 314334 helicase superfamily c-terminal domain 314336 DEAD-like helicases superfamily 314336 helicase superfamily c-terminal domain 314337 DEAD-like helicases superfamily 314337 helicase superfamily c-terminal domain 314344 Laminin G domain 314352 Fibronectin type 2 domain 314352 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences 314356 prohibitin homologues 314374 FORKHEAD 314382 Tetratricopeptide repeats 314384 RIO-like kinase 314384 Tyrosine kinase, catalytic domain 314384 Serine/Threonine protein kinases, catalytic domain 314391 Protein kinase C conserved region 2 (CalB) 314397 Src homology 2 domains 314397 Domain present in VPS9 314397 Ras association (RalGDS/AF-6) domain 314406 SERine Proteinase INhibitors 314427 domain present in cyclins, TFIIB and Retinoblastoma 314430 RNA recognition motif 314431 Alpha-lactalbumin / lysozyme C 314435 krueppel associated box 314436 erythroblast transformation specific domain 314453 WD40 repeats 314456 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins 314458 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 314461 Rab subfamily of small GTPases 314461 Ras subfamily of RAS small GTPases 314461 Rho (Ras homology) subfamily of Ras-like small GTPases 314461 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 314464 Protein present in Fab1, YOTB, Vac1, and EEA1 314465 ankyrin repeats 314465 Src homology 3 domains 314473 Formin Homology 2 Domain 314473 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 314482 Broad-Complex, Tramtrack and Bric a brac 314483 domain present in cyclins, TFIIB and Retinoblastoma 314487 Immunoglobulin C-Type 314489 Immunoglobulin 314489 Immunoglobulin V-Type 314490 von Willebrand factor (vWF) type C domain 314490 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 314491 Immunoglobulin 314491 Immunoglobulin V-Type 314492 Immunoglobulin 314492 Immunoglobulin V-Type 314493 Immunoglobulin 314493 Immunoglobulin V-Type 314494 Immunoglobulin 314494 Immunoglobulin V-Type 314495 Immunoglobulin 314495 Immunoglobulin V-Type 314496 Immunoglobulin 314496 Immunoglobulin V-Type 314497 Immunoglobulin 314497 Immunoglobulin V-Type 314498 Immunoglobulin 314498 Immunoglobulin V-Type 314499 Immunoglobulin 314499 Immunoglobulin V-Type 314500 Immunoglobulin 314500 Immunoglobulin V-Type 314501 Immunoglobulin 314501 Immunoglobulin V-Type 314502 Immunoglobulin 314502 Immunoglobulin V-Type 314503 Immunoglobulin 314503 Immunoglobulin V-Type 314504 Immunoglobulin 314504 Immunoglobulin V-Type 314505 Immunoglobulin 314505 Immunoglobulin V-Type 314506 Immunoglobulin 314506 Immunoglobulin V-Type 314507 Immunoglobulin 314507 Immunoglobulin V-Type 314508 Immunoglobulin 314508 Immunoglobulin V-Type 314509 Immunoglobulin 314509 Immunoglobulin V-Type 314509 Domain in the RNA-binding Lupus La protein 314510 Immunoglobulin 314510 Immunoglobulin V-Type 314511 Immunoglobulin 314511 Immunoglobulin V-Type 314512 Immunoglobulin 314512 Immunoglobulin V-Type 314513 Immunoglobulin 314513 Immunoglobulin V-Type 314514 Immunoglobulin 314514 Immunoglobulin V-Type 314515 Immunoglobulin 314515 Immunoglobulin V-Type 314516 Immunoglobulin 314516 Immunoglobulin V-Type 314518 Immunoglobulin 314518 Immunoglobulin V-Type 314521 Immunoglobulin 314521 Immunoglobulin V-Type 314537 ATPases associated with a variety of cellular activities 314538 von Willebrand factor (vWF) type A domain 314538 Integrin beta subunits (N-terminal portion of extracellular region) 314540 Histidine kinase-like ATPases 314543 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 314547 Armadillo/beta-catenin-like repeats 314563 helix loop helix domain 314566 snRNP Sm proteins 314575 Ubiquitin homologues 314582 Immunoglobulin 314582 Immunoglobulin V-Type 314584 krueppel associated box 314586 krueppel associated box 314588 krueppel associated box 314590 krueppel associated box 314591 krueppel associated box 314592 krueppel associated box 314596 GTPase-activator protein for Ras-like GTPases 314600 krueppel associated box 314601 krueppel associated box 314602 krueppel associated box 314603 krueppel associated box 314606 RNA recognition motif 314610 krueppel associated box 314612 Src homology 2 domains 314612 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 314613 Ring finger 314614 Acid phosphatase homologues 314615 Trypsin-like serine protease 314617 WD40 repeats 314618 Fes/CIP4 homology domain 314618 GTPase-activator protein for Rho-like GTPases 314618 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 314621 Tyrosine kinase, catalytic domain 314621 Serine/Threonine protein kinases, catalytic domain 314623 Ubiquitin homologues 314626 Netrin C-terminal Domain 314627 Tyrosine kinase, catalytic domain 314627 Serine/Threonine protein kinases, catalytic domain 314628 Methyl-CpG binding domain 314629 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 314634 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314635 snRNP Sm proteins 314638 basic region leucin zipper 314639 U1-like zinc finger 314639 domain in DSRM or ZnF_C2H2 domain containing proteins 314640 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 314640 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities 314644 E-Z type HEAT repeats 314647 RNA recognition motif 314651 krueppel associated box 314653 RNA recognition motif 314654 Myosin. Large ATPases. ATPase 314658 basic region leucin zipper 314659 Actin 314660 high mobility group 314663 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 314669 RIO-like kinase 314669 Tyrosine kinase, catalytic domain 314669 Serine/Threonine protein kinases, catalytic domain 314669 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 314670 Tyrosine kinase, catalytic domain 314670 Serine/Threonine protein kinases, catalytic domain 314675 WD40 repeats 314675 ankyrin repeats 314675 Broad-Complex, Tramtrack and Bric a brac 314678 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 314682 high mobility group 314706 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration 314711 erythroblast transformation specific domain 314712 G protein alpha subunit 314712 ARF-like small GTPases 314712 Rab subfamily of small GTPases 314712 Sar1p-like members of the Ras-family of small GTPases 314712 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 314716 Calponin homology domain 314717 Tyrosine kinase, catalytic domain 314717 Serine/Threonine protein kinases, catalytic domain 314718 Actin 314721 ankyrin repeats 314723 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 314727 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 314728 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 314743 Tyrosine kinase, catalytic domain 314743 Serine/Threonine protein kinases, catalytic domain 314745 snRNP Sm proteins 314746 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 314747 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 314747 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314754 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 314756 Caspase recruitment domain 314764 Protein present in Fab1, YOTB, Vac1, and EEA1 314771 Leucine rich repeat N-terminal domain 314777 Ricin-type beta-trefoil 314778 WD40 repeats 314785 Tetratricopeptide repeats 314795 Tetratricopeptide repeats 314805 Protein kinase C conserved region 2 (CalB) 314810 high mobility group 314813 ATPases associated with a variety of cellular activities 314814 Calponin homology domain 314830 K homology RNA-binding domain 314835 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 314842 Ricin-type beta-trefoil 314844 Ribosomal protein L11/L12 314845 Histone H3 314850 Phosphotyrosine-binding domain (IRS1-like) 314853 Alpha-lactalbumin / lysozyme C 314854 Alpha-lactalbumin / lysozyme C 314855 Zn_pept domain 314862 Tyrosine kinase, catalytic domain 314862 Serine/Threonine protein kinases, catalytic domain 314870 Tyrosine kinase, catalytic domain 314870 Serine/Threonine protein kinases, catalytic domain 314896 Serine/threonine phosphatases, family 2C, catalytic domain 314897 Serine/threonine phosphatases, family 2C, catalytic domain 314899 Histone H3 314902 Fes/CIP4 homology domain 314903 Src homology 3 domains 314903 GTPase-activator protein for Rho-like GTPases 314904 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 314907 Src homology 3 domains 314909 Src homology 2 domains 314912 RNA recognition motif 314914 Histone H3 314941 Low-density lipoprotein receptor domain class A 314941 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 314942 Domain abundant in complement control proteins 314942 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 314943 Domain abundant in complement control proteins 314944 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 314946 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 314961 Putative GTP-ase activating proteins for the small GTPase, ARF 314961 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 314964 Tudor domain 314964 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 314965 PHD zinc finger 314977 Histone H3 314979 Domain found in Dishevelled, Egl-10, and Pleckstrin 314981 Fibronectin type 3 domain 314981 von Willebrand factor (vWF) type A domain 314981 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 314988 Homeodomain 314990 Ubiquitin homologues 314993 bromo domain 314993 ATPases associated with a variety of cellular activities 314996 Kelch domain 314996 Broad-Complex, Tramtrack and Bric a brac 314997 Protein kinase C conserved region 2 (CalB) 315000 Ring finger 315033 Tetratricopeptide repeats 315034 Regulator of G protein signalling domain 315042 Tyrosine kinase, catalytic domain 315042 Serine/Threonine protein kinases, catalytic domain 315046 high mobility group 315073 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 315075 Ly-6 antigen / uPA receptor -like domain 315076 Ly-6 antigen / uPA receptor -like domain 315077 Ly-6 antigen / uPA receptor -like domain 315079 Ly-6 antigen / uPA receptor -like domain 315083 basic region leucin zipper 315087 krueppel associated box 315088 krueppel associated box 315089 ankyrin repeats 315090 Tyrosine kinase, catalytic domain 315090 Serine/Threonine protein kinases, catalytic domain 315093 WD40 repeats 315095 Tyrosine kinase, catalytic domain 315095 Serine/Threonine protein kinases, catalytic domain 315100 krueppel associated box 315101 krueppel associated box 315103 RNA recognition motif 315114 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 315115 Sec7 domain 315115 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 315122 BAR domain 315122 GTPase-activator protein for Rho-like GTPases 315124 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 315132 helicase superfamily c-terminal domain 315133 DEAD-like helicases superfamily 315133 helicase superfamily c-terminal domain 315138 Chromatin organization modifier domain 315144 Src homology 2 domains 315144 Src homology 3 domains 315151 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 315151 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation 315154 DnaJ molecular chaperone homology domain 315156 bromo domain 315156 TAZ zinc finger, present in p300 and CBP 315156 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 315159 tob/btg1 family 315170 RNA recognition motif 315174 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 315176 Calcium-binding EGF-like domain 315196 found in Wnt-1 315203 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 315206 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 315210 bromo domain 315210 PHD zinc finger 315210 domain with conserved PWWP motif 315211 BED zinc finger 315213 Furin-like repeats 315220 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 315223 Rab subfamily of small GTPases 315223 Ras subfamily of RAS small GTPases 315223 Rho (Ras homology) subfamily of Ras-like small GTPases 315223 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 315230 Protein kinase C conserved region 2 (CalB) 315238 Rab subfamily of small GTPases 315238 Rho (Ras homology) subfamily of Ras-like small GTPases 315238 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 315241 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 315248 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 315255 Zinc finger domain 315259 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 315263 Thrombospondin type 1 repeats 315265 Actin depolymerisation factor/cofilin -like domains 315284 Somatomedin B -like domains 315287 ankyrin repeats 315290 RNA recognition motif 315291 domain present in cyclins, TFIIB and Retinoblastoma 315292 Rab subfamily of small GTPases 315292 Ras subfamily of RAS small GTPases 315292 Rho (Ras homology) subfamily of Ras-like small GTPases 315294 found in Wnt-1 315298 GTPase-activator protein for Rho-like GTPases 315298 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 315299 GTPase-activator protein for Rho-like GTPases 315299 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 315310 Ricin-type beta-trefoil 315312 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 315321 Spectrin repeats 315326 Src homology 2 domains 315326 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 315327 Domain in SPla and the RYanodine Receptor. 315333 basic region leucin zipper 315337 Homeodomain 315338 Homeodomain 315341 Homeodomain 315346 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 315350 Phosphotyrosine-binding domain (IRS1-like) 315350 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 315360 von Willebrand factor (vWF) type C domain 315362 Tyrosine kinase, catalytic domain 315362 Serine/Threonine protein kinases, catalytic domain 315364 RNA recognition motif 315369 RNA recognition motif 315372 Calponin homology domain 315374 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 315378 K homology RNA-binding domain 315387 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 315388 Trypsin-like serine protease 315388 Low-density lipoprotein receptor domain class A 315389 bromo domain 315389 TAZ zinc finger, present in p300 and CBP 315389 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 315394 Kelch domain 315394 Broad-Complex, Tramtrack and Bric a brac 315399 Kelch domain 315399 Broad-Complex, Tramtrack and Bric a brac 315400 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb 315409 Domain with 2 conserved Trp (W) residues 315412 RNA recognition motif 315417 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 315422 Protein tyrosine phosphatase, catalytic domain motif 315429 Small domain found in the jumonji family of transcription factors 315429 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 315434 ankyrin repeats 315444 domain with conserved PWWP motif 315455 krueppel associated box 315467 krueppel associated box 315469 krueppel associated box 315470 krueppel associated box 315478 Domain associated with PX domains 315478 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 315487 ATPases associated with a variety of cellular activities 315492 DEAD-like helicases superfamily 315492 helicase superfamily c-terminal domain 315497 Domain first found in the mice T locus (Brachyury) protein 315500 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 315509 Immunoglobulin 315509 Immunoglobulin V-Type 315509 Immunoglobulin C-2 Type 315510 Immunoglobulin 315510 Immunoglobulin C-2 Type 315510 Fibronectin type 3 domain 315527 Homeodomain 315530 GTPase-activator protein for Rho-like GTPases 315532 erythroblast transformation specific domain 315533 SAM / Pointed domain 315545 Immunoglobulin 315545 Immunoglobulin C-2 Type 315546 Immunoglobulin 315546 Immunoglobulin C-2 Type 315548 ATPases associated with a variety of cellular activities 315558 RNA recognition motif 315575 leucine rich region 315575 krueppel associated box 315579 Src homology 3 domains 315593 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps 315597 Frizzled 315597 Low-density lipoprotein receptor domain class A 315597 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 315598 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 315600 Ring finger 315600 Clathrin heavy chain repeat homology 315604 DEAD-like helicases superfamily 315604 helicase superfamily c-terminal domain 315606 PHD zinc finger 315606 "FY-rich" domain, C-terminal region 315606 "FY-rich" domain, N-terminal region 315606 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 315608 Modified RING finger domain 315609 Immunoglobulin C-2 Type 315610 Immunoglobulin 315610 Immunoglobulin V-Type 315611 Immunoglobulin 315611 Immunoglobulin V-Type 315618 Serine/Threonine protein kinases, catalytic domain 315634 RNA recognition motif 315638 Fibronectin type 3 domain 315650 tob/btg1 family 315655 Band 4.1 homologues 315664 Filamin-type immunoglobulin domains 315664 Putative lipopolysaccharide-modifying enzyme 315668 ARF-like small GTPases 315668 Rab subfamily of small GTPases 315668 Ras subfamily of RAS small GTPases 315668 Sar1p-like members of the Ras-family of small GTPases 315668 Rho (Ras homology) subfamily of Ras-like small GTPases 315668 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 315675 Olfactomedin-like domains 315685 Serine/Threonine protein kinases, catalytic domain 315689 high mobility group 315691 Immunoglobulin 315691 Immunoglobulin C-2 Type 315694 Immunoglobulin 315696 Src homology 3 domains 315696 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform 315699 Protein tyrosine phosphatase, catalytic domain 315699 Protein tyrosine phosphatase, catalytic domain motif 315707 Src homology 2 domains 315707 Tyrosine kinase, catalytic domain 315707 Serine/Threonine protein kinases, catalytic domain 315712 Protein kinase C conserved region 2 (CalB) 315716 Immunoglobulin V-Type 315716 Immunoglobulin C-2 Type 315716 Immunoglobulin 315716 Immunoglobulin V-Type 315716 Immunoglobulin C-2 Type 315731 Domain in the RNA-binding Lupus La protein 315740 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 315744 von Willebrand factor (vWF) type A domain 315744 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 315745 ankyrin repeats 315755 Thymosin beta actin-binding motif 315761 Immunoglobulin 315761 Immunoglobulin C-2 Type 315762 Rab subfamily of small GTPases 315762 Ras subfamily of RAS small GTPases 315762 Rho (Ras homology) subfamily of Ras-like small GTPases 315764 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 315765 RNA recognition motif 315771 WD40 repeats 315771 Domain in SPla and the RYanodine Receptor. 315771 Domain Homologous to E6-AP Carboxyl Terminus with 315776 I/LWEQ domain 315776 Band 4.1 homologues 315790 RNA polymerase subunit CX 315792 RNA recognition motif 315806 Immunoglobulin 315806 Immunoglobulin C-2 Type 315806 Fibronectin type 3 domain 315813 Protein kinase C conserved region 2 (CalB) 315824 Transforming growth factor-beta (TGF-beta) family 315828 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 315833 Kelch domain 315833 Broad-Complex, Tramtrack and Bric a brac 315836 Ribosomal protein L11/L12 315840 Myosin. Large ATPases. ATPase 315843 bromo domain 315852 RIO-like kinase 315852 Tyrosine kinase, catalytic domain 315852 Serine/Threonine protein kinases, catalytic domain 315858 Broad-Complex, Tramtrack and Bric a brac 315866 Trypsin-like serine protease 315870 Domain first found in the mice T locus (Brachyury) protein 315871 Domain associated with PX domains 315871 Regulator of G protein signalling domain 315872 krueppel associated box 315876 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 315877 Guanine nucleotide exchange factor for Ras-like small GTPases 315877 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 315879 Thrombospondin type 1 repeats 315880 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 315903 RNA recognition motif 315903 Suppressor-of-White-APricot splicing regulator 315903 domain present in proteins, which are involved in regulation of nuclear pre-mRNA 315907 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 315908 Domain of unknown function present in FAF1 (Fas-associated factor 1) 315909 14-3-3 homologues 315911 Ring finger 315912 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 315912 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 315914 Histidine kinase-like ATPases 315919 Domain in SPla and the RYanodine Receptor. 315920 Immunoglobulin 315920 Immunoglobulin C-2 Type 315923 Lysin motif 315926 Eps15 homology domain 315926 Calponin homology domain 315926 EF-hand, calcium binding motif 315932 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 315935 Protein kinase C conserved region 2 (CalB) 315936 Broad-Complex, Tramtrack and Bric a brac 315946 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 315947 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 315962 Transglutaminase/protease-like homologues 315963 Transferrin 315964 Transferrin 315968 ARF-like small GTPases 315968 Rab subfamily of small GTPases 315968 Ras subfamily of RAS small GTPases 315968 Rho (Ras homology) subfamily of Ras-like small GTPases 315968 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 315969 breast cancer carboxy-terminal domain 315971 high mobility group 315975 DnaJ molecular chaperone homology domain 315978 Tyrosine kinase, catalytic domain 315978 Serine/Threonine protein kinases, catalytic domain 315979 von Willebrand factor (vWF) type A domain 315980 von Willebrand factor (vWF) type A domain 315981 von Willebrand factor (vWF) type A domain 315982 WD40 repeats 315988 RNA recognition motif 315994 Tyrosine kinase, catalytic domain 315994 Serine/Threonine protein kinases, catalytic domain 315996 Immunoglobulin 315996 semaphorin domain 315996 Immunoglobulin C-2 Type 315996 domain found in Plexins, Semaphorins and Integrins 315997 glycine rich nucleic binding domain 316002 Domain in SPla and the RYanodine Receptor. 316003 Immunoglobulin C-2 Type 316003 Immunoglobulin C-2 Type 316005 In Between Ring fingers 316006 RIIalpha, Regulatory subunit portion of type II PKA R-subunit 316009 semaphorin domain 316009 ig-like, plexins, transcription factors 316009 GTPase-activator protein for Ras-like GTPases 316009 domain found in Plexins, Semaphorins and Integrins 316012 Kelch domain 316012 Broad-Complex, Tramtrack and Bric a brac 316014 WD40 repeats 316016 Trypsin-like serine protease 316017 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases 316023 Tyrosine kinase, catalytic domain 316023 Domain in the Doublecortin (DCX) gene product 316023 Serine/Threonine protein kinases, catalytic domain 316028 Putative single-stranded nucleic acids-binding domain 316032 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 316052 Domain first found in the mice T locus (Brachyury) protein 316055 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 316064 Tyrosine kinase, catalytic domain 316064 Serine/Threonine protein kinases, catalytic domain 316066 Tyrosine kinase, catalytic domain 316066 Serine/Threonine protein kinases, catalytic domain 316080 snRNP Sm proteins 316086 Alpha-lactalbumin / lysozyme C 316087 Broad-Complex, Tramtrack and Bric a brac 316088 Kelch domain 316088 Broad-Complex, Tramtrack and Bric a brac 316090 krueppel associated box 316094 leucine rich region 316095 leucine rich region 316097 RNA recognition motif 316099 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 316101 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 316103 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 316105 krueppel associated box 316106 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 316109 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 316118 breast cancer carboxy-terminal domain 316119 Transferrin 316126 Ran-binding domain 316129 Ring finger 316129 PHD zinc finger 316129 Ubiquitin homologues 316129 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. Domain in SET domain containing proteins and in Deinococcus radiodurans DRA1533 316130 Toll - interleukin 1 - resistance 316131 ankyrin repeats 316137 Calcium-binding EGF-like domain 316137 G-protein-coupled receptor proteolytic site domain 316157 Serine/threonine phosphatases, family 2C, catalytic domain 316166 Homeodomain 316173 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 316174 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 316201 Formin Homology 2 Domain 316205 Immunoglobulin 316205 Immunoglobulin C-2 Type 316208 FORKHEAD 316211 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 316212 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 316213 Phosphotyrosine-binding domain (IRS1-like) 316214 helix loop helix domain 316216 Bromodomain transcription factors and PHD domain containing proteins 316219 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 316221 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 316231 ATPases associated with a variety of cellular activities 316256 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers 316258 Src homology 3 domains 316258 Src homology 3 domains 316259 G-protein-coupled receptor proteolytic site domain 316266 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 316273 minichromosome maintenance proteins 316294 Thrombospondin type 1 repeats 316294 G-protein-coupled receptor proteolytic site domain 316296 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 316299 RNA recognition motif 316310 Rab subfamily of small GTPases 316310 Ras subfamily of RAS small GTPases 316310 Rho (Ras homology) subfamily of Ras-like small GTPases 316310 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 316313 Calponin homology domain 316317 Protein tyrosine phosphatase, catalytic domain 316318 Trypsin-like serine protease 316326 Ring finger 316326 domain in neuralized proteins 316327 ARID (A/T-rich interaction domain) domain 316330 ankyrin repeats 316333 Actin 316344 breast cancer carboxy-terminal domain 316364 RNA recognition motif 316369 Src homology 2 domains 316369 Src homology 3 domains 316370 Filamin-type immunoglobulin domains 316370 Putative lipopolysaccharide-modifying enzyme 316373 high mobility group 316378 high mobility group 316390 WD40 repeats 316393 Domain Homologous to E6-AP Carboxyl Terminus with 316395 Domain with 2 conserved Trp (W) residues 316395 Domain Homologous to E6-AP Carboxyl Terminus with 316408 Homeodomain 316409 heat shock factor 316444 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th 316446 Zn_pept domain 316452 domain present in cyclins, TFIIB and Retinoblastoma 316455 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 316468 WD40 repeats 316482 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 316483 14-3-3 homologues 316495 GTPase-activator protein for Rho-like GTPases 316498 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316501 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316502 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316504 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 316506 Fibronectin type 3 domain 316507 Src homology 2 domains 316520 catalytic domain of ctd-like phosphatases 316521 Gelsolin homology domain 316526 found in Wnt-1 316527 found in Wnt-1 316532 Immunoglobulin 316532 Immunoglobulin C-2 Type 316541 Ephrin receptor ligand binding domain 316550 ARF-like small GTPases 316550 Rab subfamily of small GTPases 316550 Ras subfamily of RAS small GTPases 316550 Rho (Ras homology) subfamily of Ras-like small GTPases 316550 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 316552 Ring finger 316566 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain 316573 Calcium-binding EGF-like domain 316577 A Receptor for Ubiquitination Targets 316580 SAND domain 316580 bromo domain 316580 PHD zinc finger 316595 Contains conserved Gly-Tyr-Phe residues 316608 Ras subfamily of RAS small GTPases 316610 Putative GTP-ase activating proteins for the small GTPase, ARF 316610 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 316611 ankyrin repeats 316611 Putative GTP-ase activating proteins for the small GTPase, ARF 316614 ankyrin repeats 316624 Kelch domain 316624 Broad-Complex, Tramtrack and Bric a brac 316626 Orange domain 316628 ankyrin repeats 316628 suppressors of cytokine signalling 316637 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316638 Fibronectin type 3 domain 316638 Calcium-binding EGF-like domain 316639 Band 4.1 homologues 316656 Laminin G domain 316657 Coagulation factor 5/8 C-terminal domain, discoidin domain 316660 Ran-binding domain 316663 A Receptor for Ubiquitination Targets 316679 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 316679 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 316689 Protein kinase C conserved region 2 (CalB) 316690 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 316691 Ribosomal protein S1-like RNA-binding domain 316691 domain in chromatin remodeling S1 domain containing proteins and zinc fingers 316700 Tyrosine kinase, catalytic domain 316700 Extension to Ser/Thr-type protein kinases 316700 Serine/Threonine protein kinases, catalytic domain 316708 Histone 2A 316717 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 316718 krueppel associated box 316721 krueppel associated box 316722 krueppel associated box 316723 krueppel associated box 316725 RNA recognition motif 316733 Cold shock protein domain 316736 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 316740 Immunoglobulin 316740 Immunoglobulin C-2 Type 316740 Fibronectin type 3 domain 316742 Homeodomain 316762 Fibronectin type 3 domain 316763 ARF-like small GTPases 316763 Rab subfamily of small GTPases 316763 Ras subfamily of RAS small GTPases 316763 Rho (Ras homology) subfamily of Ras-like small GTPases 316763 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 316765 DEAD-like helicases superfamily 316765 Tyrosine kinase, catalytic domain 316765 Serine/Threonine protein kinases, catalytic domain 316767 DEAD-like helicases superfamily 316767 helicase superfamily c-terminal domain 316768 Serine/Threonine protein kinases, catalytic domain 316769 Serine/Threonine protein kinases, catalytic domain 316770 Serine/Threonine protein kinases, catalytic domain 316771 DEAD-like helicases superfamily 316781 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 316794 JAB/MPN domain 316818 krueppel associated box 316826 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 316837 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316860 Tyrosine kinase, catalytic domain 316860 Serine/Threonine protein kinases, catalytic domain 316862 Tyrosine kinase, catalytic domain 316862 Serine/Threonine protein kinases, catalytic domain 316876 Rab subfamily of small GTPases 316876 Ras subfamily of RAS small GTPases 316876 Rho (Ras homology) subfamily of Ras-like small GTPases 316876 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 316877 Rab subfamily of small GTPases 316877 Ras subfamily of RAS small GTPases 316881 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316884 Ubiquitin homologues 316884 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316898 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316899 Ubiquitin homologues 316900 Ubiquitin homologues 316918 Laminin G domain 316925 Myosin. Large ATPases. ATPase 316943 Myosin. Large ATPases. ATPase 316945 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 316949 Myosin. Large ATPases. ATPase 316951 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 316953 Ubiquitin homologues 316962 krueppel associated box 316965 GTPase-activator protein for Rho-like GTPases 316967 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316970 GTPase-activator protein for Rho-like GTPases 316973 Myosin. Large ATPases. ATPase 316986 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 316987 Ubiquitin homologues 316990 Histone 2A 316996 RIO-like kinase 316996 Tyrosine kinase, catalytic domain 316996 Serine/Threonine protein kinases, catalytic domain 316997 Myosin. Large ATPases. ATPase 317002 Myosin. Large ATPases. ATPase 317006 Tyrosine kinase, catalytic domain 317006 Serine/Threonine protein kinases, catalytic domain 317010 Myosin. Large ATPases. ATPase 317012 Myosin. Large ATPases. ATPase 317017 Myosin. Large ATPases. ATPase 317019 Myosin. Large ATPases. ATPase 317023 Myosin. Large ATPases. ATPase 317027 Found in Skp1 protein family 317031 Middle domain of eukaryotic initiation factor 4G (eIF4G) 317031 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 317034 Middle domain of eukaryotic initiation factor 4G (eIF4G) 317034 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 317047 Immunoglobulin 317047 Immunoglobulin C-2 Type 317053 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 317064 ARF-like small GTPases 317064 Rab subfamily of small GTPases 317064 Ras subfamily of RAS small GTPases 317064 Rho (Ras homology) subfamily of Ras-like small GTPases 317064 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 317067 GTPase-activator protein for Rho-like GTPases 317067 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 317070 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 317071 Ubiquitin homologues 317085 Myosin. Large ATPases. ATPase 317086 Myosin. Large ATPases. ATPase 317088 Myosin. Large ATPases. ATPase 317091 Myosin. Large ATPases. ATPase 317100 Myosin. Large ATPases. ATPase 317102 Myosin. Large ATPases. ATPase 317112 Myosin. Large ATPases. ATPase 317114 Myosin. Large ATPases. ATPase 317115 Myosin. Large ATPases. ATPase 317131 Tyrosine kinase, catalytic domain 317131 Serine/Threonine protein kinases, catalytic domain 317142 Myosin. Large ATPases. ATPase 317149 Tyrosine kinase, catalytic domain 317149 Serine/Threonine protein kinases, catalytic domain 317150 Tyrosine kinase, catalytic domain 317150 Serine/Threonine protein kinases, catalytic domain 317152 Myosin. Large ATPases. ATPase 317153 Immunoglobulin 317153 Immunoglobulin V-Type 317154 Immunoglobulin V-Type 317155 Immunoglobulin 317155 Immunoglobulin V-Type 317163 eukaryotic translation initiation factor 1A 317178 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 317181 Domain abundant in complement control proteins 317183 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 317187 snRNP Sm proteins 317189 Formin Homology 2 Domain 317196 Kelch domain 317196 Broad-Complex, Tramtrack and Bric a brac 317203 Tyrosine kinase, catalytic domain 317203 Extension to Ser/Thr-type protein kinases 317203 Serine/Threonine protein kinases, catalytic domain 317204 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 317205 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 317208 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 317211 prohibitin homologues 317213 bromo domain 317217 Histone H3 317221 zinc finger 317224 Fibronectin type 3 domain 317226 Fibronectin type 3 domain 317227 Toll - interleukin 1 - resistance 317233 Armadillo/beta-catenin-like repeats 317236 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin 317241 Ring finger 317252 DEAD-like helicases superfamily 317252 helicase superfamily c-terminal domain 317256 bromo domain 317259 RNA recognition motif 317268 Homeodomain 317276 GTPase-activator protein for Rho-like GTPases 317279 Ubiquitin homologues 317285 Ubiquitin homologues 317292 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 317293 krueppel associated box 317294 krueppel associated box 317296 Protein tyrosine phosphatase, catalytic domain motif 317296 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 317298 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 317308 zinc finger 317309 RNA recognition motif 317313 snRNP Sm proteins 317314 high mobility group 317318 high mobility group 317321 high mobility group 317323 high mobility group 317326 high mobility group 317332 C-terminal cystine knot-like domain (CTCK) 317335 DEAD-like helicases superfamily 317335 helicase superfamily c-terminal domain 317339 DEAD-like helicases superfamily 317339 helicase superfamily c-terminal domain 317341 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 317346 ankyrin repeats 317352 Histone 2A 317353 Histone 2A 317354 Histone 2A 317356 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 317358 Histone 2A 317361 krueppel associated box 317362 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 317364 Domain with 2 conserved Trp (W) residues 317369 RRM_1 domain 317369 RNA recognition motif 317370 WD40 repeats 317371 P21-Rho-binding domain 317371 WASP homology region 1 317376 helix loop helix domain 317379 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 317380 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 317382 FORKHEAD 317385 RNA recognition motif 317389 domain present in cyclins, TFIIB and Retinoblastoma 317390 zinc finger 317392 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 317396 Ubiquitin homologues 317396 Ubiquitin associated domain 317399 DEAD-like helicases superfamily 317399 helicase superfamily c-terminal domain 317401 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 317415 minichromosome maintenance proteins 317416 Vault protein Inter-alpha-Trypsin domain 317416 von Willebrand factor (vWF) type A domain 317417 Ubiquitin homologues 317417 RNA recognition motif 317420 Tyrosine kinase, catalytic domain 317420 Serine/Threonine protein kinases, catalytic domain 317422 ankyrin repeats 317425 PHD zinc finger 317425 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 317426 Ubiquitin homologues 317427 Serine/Threonine protein kinases, catalytic domain 317433 Sec7 domain 317439 Domain with 2 conserved Trp (W) residues 317464 Chromatin organization modifier domain 317468 Toll - interleukin 1 - resistance 317470 Calcium-binding EGF-like domain 317470 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 317471 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 317476 RRM_1 domain 317476 RNA recognition motif 317479 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 317481 ankyrin repeats 317486 Ring finger 317491 Eps15 homology domain 317496 Tyrosine kinase, catalytic domain 317496 Serine/Threonine protein kinases, catalytic domain 317498 Eps15 homology domain 317498 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 317509 WD40 repeats 317515 Epsin N-terminal homology (ENTH) domain 317521 Tyrosine kinase, catalytic domain 317521 Extension to Ser/Thr-type protein kinases 317521 Serine/Threonine protein kinases, catalytic domain 317525 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration 317530 Histone H3 317533 Ring finger 317533 RNA recognition motif 317537 Calponin homology domain 317538 Spectrin repeats 317539 Spectrin repeats 317545 Ubiquitin homologues 317550 ARF-like small GTPases 317550 Rab subfamily of small GTPases 317550 Ras subfamily of RAS small GTPases 317550 Sar1p-like members of the Ras-family of small GTPases 317550 Rho (Ras homology) subfamily of Ras-like small GTPases 317550 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 317553 Immunoglobulin 317553 Immunoglobulin 317553 Immunoglobulin C-2 Type 317553 Toll - interleukin 1 - resistance 317566 zinc finger 317571 high mobility group 317572 high mobility group 317574 high mobility group 317575 DEAD-like helicases superfamily 317575 helicase superfamily c-terminal domain 317575 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 317576 GTPase-activator protein for Rho-like GTPases 317576 Inositol polyphosphate phosphatase, catalytic domain homologues 317578 Src homology 3 domains 317578 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 317580 ARF-like small GTPases 317580 Rab subfamily of small GTPases 317580 Ras subfamily of RAS small GTPases 317580 Rho (Ras homology) subfamily of Ras-like small GTPases 317580 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 317581 RNA recognition motif 317583 high mobility group 317584 high mobility group 317585 high mobility group 317589 Tyrosine kinase, catalytic domain 317589 Serine/Threonine protein kinases, catalytic domain 317597 high mobility group 317598 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 317601 high mobility group 317602 high mobility group 317604 high mobility group 317605 high mobility group 317609 high mobility group 317610 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 317612 RRM_1 domain 317612 RNA recognition motif 317613 RNA recognition motif 317627 bromo domain 317627 PHD zinc finger 317631 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 317652 Trypsin-like serine protease 317653 Trypsin-like serine protease 317674 Frizzled 317677 Trypsin-like serine protease 317677 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 317719 Kelch domain 317772 Histone 2A 319110 RNA recognition motif 319146 Interferon alpha, beta and delta 319146 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 319148 Histone H3 319149 Histone H3 319150 Histone H3 319151 Histone H3 319152 Histone H3 319153 Histone H3 319154 Histone H3 319155 Histone H4 319156 Histone H4 319157 Histone H4 319159 Histone H4 319160 Histone H4 319161 Histone H4 319162 Histone 2A 319163 Histone 2A 319164 Histone 2A 319164 Histone 2A 319165 Histone 2A 319166 Histone 2A 319166 Histone 2A 319167 Histone 2A 319168 Histone 2A 319169 Histone 2A 319170 Histone 2A 319171 Histone 2A 319172 Histone 2A 319173 Histone 2A 319175 Histone 2A 319176 Histone 2A 319177 Histone H2B 319178 Histone H2B 319179 Histone H2B 319179 Histone H2B 319180 Histone H2B 319181 Histone H2B 319182 Histone H2B 319183 Histone H2B 319184 Histone H2B 319185 Histone H2B 319186 Histone H2B 319187 Histone H2B 319188 Histone H2B 319189 Histone H2B 319189 Histone H2B 319190 Histone H3 319191 Histone 2A 319192 Histone 2A 319193 Histone H3 319196 ankyrin repeats 319236 Domain in SPla and the RYanodine Receptor. 319249 Rab subfamily of small GTPases 319249 Ras subfamily of RAS small GTPases 319249 Rho (Ras homology) subfamily of Ras-like small GTPases 319249 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 319262 Src homology 3 domains 319262 Src homology 3 domains 319322 Basic domain in HLH proteins of MYOD family 319322 proline-rich domain in spliceosome associated proteins 319358 RNA recognition motif 319387 Olfactomedin-like domains 319387 Domain present in hormone receptors 319387 G-protein-coupled receptor proteolytic site domain 319433 SERine Proteinase INhibitors 319448 Fibronectin type 3 domain 319468 Serine/threonine phosphatases, family 2C, catalytic domain 319468 Serine/threonine phosphatases, family 2C, catalytic domain 319476 Leucine rich repeat N-terminal domain 319480 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f 319480 Integrin alpha (beta-propellor repeats) 319480 von Willebrand factor (vWF) type A domain 319480 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo 319481 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 319481 WD40 repeats 319481 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain 319482 von Willebrand factor (vWF) type D domain 319482 von Willebrand factor (vWF) type D domain 319489 Immunoglobulin 319489 Immunoglobulin 319489 Immunoglobulin C-2 Type 319504 Immunoglobulin 319504 Immunoglobulin C-2 Type 319504 Immunoglobulin 319504 Immunoglobulin C-2 Type 319504 Fibronectin type 3 domain 319508 Protein kinase C conserved region 2 (CalB) 319520 Rhodanese Homology Domain 319520 Rhodanese Homology Domain 319520 Protein tyrosine phosphatase, catalytic domain 319520 Dual specificity phosphatase, catalytic domain 319520 Protein tyrosine phosphatase, catalytic domain motif 319535 krueppel associated box 319555 WD40 repeats 319573 DEAD-like helicases superfamily 319583 breast cancer carboxy-terminal domain 319586 RNA recognition motif 319586 RNA recognition motif 319594 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 319605 Leucine-rich repeat - CC (cysteine-containing) subfamily 319636 B-Box C-terminal domain 319642 Rab subfamily of small GTPases 319642 Ras subfamily of RAS small GTPases 319642 Rho (Ras homology) subfamily of Ras-like small GTPases 319642 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 319701 A Receptor for Ubiquitination Targets 319701 A Receptor for Ubiquitination Targets 319710 Band 4.1 homologues 319710 Band 4.1 homologues 319734 von Willebrand factor (vWF) type A domain 319740 Protein present in Fab1, YOTB, Vac1, and EEA1 319740 Protein present in Fab1, YOTB, Vac1, and EEA1 319757 Frizzled 319757 Frizzled 319765 K homology RNA-binding domain 319817 Ring finger 319822 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 319822 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 319875 Trypsin-like serine protease 319875 Trypsin-like serine protease 319888 N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4). Also present in several other worm and fly proteins 319888 N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4). Also present in several other worm and fly proteins 319924 Domain present in PSD-95, Dlg, and ZO-1/2 319924 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 319965 Protein kinase C conserved region 2 (CalB) 319965 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 319965 Protein kinase C conserved region 2 (CalB) 319965 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 319991 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 320027 Immunoglobulin C-2 Type 320040 Ring finger 320078 Olfactomedin-like domains 320082 A Receptor for Ubiquitination Targets 320109 Calponin homology domain 320116 Fibronectin type 3 domain 320119 Serine/Threonine protein kinases, catalytic domain 320119 Tyrosine kinase, catalytic domain 320119 Serine/Threonine protein kinases, catalytic domain 320119 erine/Threonine protein kinases, catalytic domain 320127 Diacylglycerol kinase accessory domain (presumed) 320129 Serine/Threonine protein kinases, catalytic domain 320129 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 320129 Regulator of G protein signalling domain 320139 Protein tyrosine phosphatase, catalytic domain 320139 Protein tyrosine phosphatase, catalytic domain 320148 Immunoglobulin 320148 Immunoglobulin 320158 U1-like zinc finger 320158 U1-like zinc finger 320182 helix loop helix domain 320202 Transforming growth factor-beta (TGF-beta) family 320209 DEAD-like helicases superfamily 320209 helicase superfamily c-terminal domain 320267 K homology RNA-binding domain 320292 Guanine nucleotide exchange factor for Ras-like GTPases 320292 Guanine nucleotide exchange factor for Ras-like small GTPases 320292 Guanine nucleotide exchange factor for Ras-like GTPases 320292 Guanine nucleotide exchange factor for Ras-like small GTPases 320292 Guanine nucleotide exchange factor for Ras-like GTPases 320292 Guanine nucleotide exchange factor for Ras-like small GTPases 320299 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 320311 Ring finger 320332 Histone H4 320332 Histone H4 320376 ankyrin repeats 320405 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 320405 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 320407 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 320407 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 320452 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu 320452 Prolyl 4-hydroxylase alpha subunit homologues 320452 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut 320454 Trypsin-like serine protease 320454 Trypsin-like serine protease 320454 Domain found in sea urchin sperm protein, enterokinase, agrin 320484 GTPase-activator protein for Ras-like GTPases 320484 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 320484 GTPase-activator protein for Ras-like GTPases 320484 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 320522 helix loop helix domain 320560 domain involved in Ras-like GTPase signaling 320568 ATPases associated with a variety of cellular activities 320595 PHD zinc finger 320595 PHD zinc finger 320595 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes 320634 Inositol polyphosphate phosphatase, catalytic domain homologues 320634 GTPase-activator protein for Rho-like GTPases 320634 Inositol polyphosphate phosphatase, catalytic domain homologues 320640 Immunoglobulin 320640 Immunoglobulin 320640 Immunoglobulin V-Type 320664 Src homology 3 domains 320676 DEAD-like helicases superfamily 320676 Chromatin organization modifier domain 320681 Immunoglobulin 320681 Immunoglobulin C-2 Type 320712 Fibronectin type 3 domain 320713 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains 320717 Sigma factor PP2C-like phosphatases 320717 Serine/threonine phosphatases, family 2C, catalytic domain 320734 Immunoglobulin V-Type 320734 Immunoglobulin 320734 Immunoglobulin V-Type 320734 Immunoglobulin 320734 Immunoglobulin V-Type 320747 Immunoglobulin 320747 Immunoglobulin 320747 Immunoglobulin C-2 Type 320747 Leucine-rich repeats, typical (most populated) subfamily 320795 Extension to Ser/Thr-type protein kinases 320795 Serine/Threonine protein kinases, catalytic domain 320799 Homeodomain 320799 Homeodomain 320808 WD40 repeats 320825 Sterile alpha motif 320825 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 320832 Immunoglobulin 320832 Immunoglobulin C-Type 320840 Immunoglobulin 320840 Immunoglobulin C-2 Type 320840 Immunoglobulin 320840 Immunoglobulin C-2 Type 320844 Immunoglobulin 320858 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 320858 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 320873 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 320878 Calponin homology domain 320878 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 320898 Immunoglobulin 320898 Immunoglobulin 320898 Immunoglobulin V-Type 320898 Immunoglobulin 320898 Immunoglobulin V-Type 320910 von Willebrand factor (vWF) type A domain 320910 Integrin beta subunits (N-terminal portion of extracellular region) 320913 Immunoglobulin V-Type 320924 Calcium-binding EGF-like domain 320924 Calcium-binding EGF-like domain 320963 RNA recognition motif 320974 Fibronectin type 3 domain 320974 Fibronectin type 3 domain 326619 Histone H4 326620 Histone H4 326623 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor 327729 Ribosomal protein L11/L12 327734 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 327736 Ribosomal protein L11/L12 327737 Lysin motif 327762 DEAD-like helicases superfamily 327799 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger 327803 SAND domain 327803 PHD zinc finger 327811 RNA recognition motif 327814 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 327814 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 327822 Ricin-type beta-trefoil 327826 Phosphotyrosine-binding domain (IRS1-like) 327830 Tyrosine kinase, catalytic domain 327830 Serine/Threonine protein kinases, catalytic domain 327842 Gelsolin homology domain 327844 snRNP Sm proteins 327859 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 327868 Ubiquitin homologues 327873 Src homology 3 domains 327873 Domain present in VPS-27, Hrs and STAM 327880 Ribosomal protein L11/L12 327883 Rab subfamily of small GTPases 327883 Ras subfamily of RAS small GTPases 327900 Ubiquitin homologues 327929 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 327930 Guanine nucleotide exchange factor for Ras-like small GTPases 327944 high mobility group 327963 krueppel associated box 327979 Ribosomal protein L11/L12 327981 Four-disulfide core domains 327991 Sigma factor PP2C-like phosphatases 327991 Serine/threonine phosphatases, family 2C, catalytic domain 327995 RNA recognition motif 328022 Tyrosine kinase, catalytic domain 328022 Serine/Threonine protein kinases, catalytic domain 328032 Immunoglobulin 328032 Immunoglobulin V-Type 328033 Immunoglobulin 328033 Immunoglobulin V-Type 328034 Immunoglobulin 328034 Immunoglobulin V-Type 328050 high mobility group 328076 Immunoglobulin 328076 Immunoglobulin 328076 Immunoglobulin C-2 Type 328106 Immunoglobulin 328106 Immunoglobulin C-2 Type 328106 Leucine rich repeat C-terminal domain 328146 SERine Proteinase INhibitors 328148 SERine Proteinase INhibitors 328149 SERine Proteinase INhibitors 328167 Immunoglobulin 328167 Immunoglobulin V-Type 328168 Immunoglobulin V-Type 328173 Tyrosine kinase, catalytic domain 328173 Serine/Threonine protein kinases, catalytic domain 328174 ATPases associated with a variety of cellular activities 328198 leucine rich region 328201 Histone H2B 328208 Histone H2B 328242 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 328248 von Willebrand factor (vWF) type C domain 328251 Histone 2A 328266 Papain family cysteine protease 328267 Papain family cysteine protease 328268 Papain family cysteine protease 328269 Low molecular weight phosphatase family 328274 krueppel associated box 328274 krueppel associated box 328279 krueppel associated box 328280 krueppel associated box 328323 Tyrosine kinase, catalytic domain 328323 erine/Threonine protein kinases, catalytic domain 328323 Serine/Threonine protein kinases, catalytic domain 328329 Tyrosine kinase, catalytic domain 328329 Extension to Ser/Thr-type protein kinases 328329 Serine/Threonine protein kinases, catalytic domain 328329 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 328351 Calponin homology domain 328381 Src homology 2 domains 328381 Src homology 2 domains 328401 Pancreatic ribonuclease 328410 Immunoglobulin 328410 Immunoglobulin V-Type 328410 Immunoglobulin C-2 Type 328413 Myosin. Large ATPases. ATPase 328415 ig-like, plexins, transcription factors 328417 breast cancer carboxy-terminal domain 328417 Vault protein Inter-alpha-Trypsin domain 328417 von Willebrand factor (vWF) type A domain 328424 Broad-Complex, Tramtrack and Bric a brac 328451 RNA recognition motif 328467 Low molecular weight phosphatase family 328482 Immunoglobulin 328482 Immunoglobulin V-Type 328483 Immunoglobulin 328483 Immunoglobulin V-Type 328484 Immunoglobulin V-Type 328486 Pancreatic ribonuclease 328499 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 328505 Immunoglobulin V-Type 328505 Immunoglobulin V-Type 328537 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 328549 high mobility group 328551 Ly-6 antigen / uPA receptor -like domain 328572 TAZ zinc finger, present in p300 and CBP 328640 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 328715 Tyrosine kinase, catalytic domain 328715 Serine/Threonine protein kinases, catalytic domain 328730 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 328731 ARID (A/T-rich interaction domain) domain 328749 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 328778 ARF-like small GTPases 328778 Rab subfamily of small GTPases 328778 Ras subfamily of RAS small GTPases 328778 Rho (Ras homology) subfamily of Ras-like small GTPases 328778 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 328780 Trypsin-like serine protease 328780 Trypsin-like serine protease 328782 Trypsin-like serine protease 328787 Histone H3 328788 Colipase 328795 Src homology 3 domains 328795 Src homology 3 domains 328809 Immunoglobulin C-Type 328826 Immunoglobulin 328826 Immunoglobulin C-2 Type 328829 Immunoglobulin 328829 Immunoglobulin 328829 Immunoglobulin V-Type 328830 Immunoglobulin 328830 Immunoglobulin 328851 Rab subfamily of small GTPases 328851 Ras subfamily of RAS small GTPases 328851 Rho (Ras homology) subfamily of Ras-like small GTPases 328874 A Receptor for Ubiquitination Targets 328877 WD40 repeats 328882 GTPase-activator protein for Rho-like GTPases 328885 Guanine nucleotide exchange factor for Ras-like GTPases 328895 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 328897 zinc finger binding to DNA consensus sequence [AT]GATA[AG] 328901 Laminin G domain 328901 Thrombospondin N-terminal -like domains 328901 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 328902 ankyrin repeats 328909 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 328918 leucine rich region 328948 high mobility group 328967 BAR domain 328967 Src homology 3 domains 328967 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 328967 BAR domain 328967 Src homology 3 domains 328967 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 328971 Kazal type serine protease inhibitors 328971 Kazal type serine protease inhibitors 328973 WD40 repeats 328992 Lipoxygenase homology 2 (beta barrel) domain 329037 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 329052 high mobility group 329081 Immunoglobulin 329081 Immunoglobulin V-Type 329087 14-3-3 homologues 329093 Zn_pept domain 329093 Zn_pept domain 329140 Bromodomain transcription factors and PHD domain containing proteins 329146 Tyrosine kinase, catalytic domain 329146 Serine/Threonine protein kinases, catalytic domain 329154 ankyrin repeats 329236 krueppel associated box 329244 Interleukin-10 family 329248 Phosphoinositide 3-kinase, catalytic domain 329249 Protein kinase C conserved region 2 (CalB) 329251 ankyrin repeats 329269 Calcium-binding EGF-like domain 329278 Fibronectin type 3 domain 329278 Fibrinogen-related domains (FReDs) 329278 Fibronectin type 3 domain 329278 Fibrinogen-related domains (FReDs) 329302 Tyrosine kinase, catalytic domain 329302 Serine/Threonine protein kinases, catalytic domain 329303 P21-Rho-binding domain 329303 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 329319 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 329322 meprin and TRAF homology 329324 Protein kinase C conserved region 2 (CalB) 329336 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 329339 Broad-Complex, Tramtrack and Bric a brac 329341 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 329357 Domain with 2 conserved Trp (W) residues 329357 Domain Homologous to E6-AP Carboxyl Terminus with 329360 Ring finger 329416 Src homology 3 domains 329416 Fes/CIP4 homology domain 329416 Src homology 3 domains 329419 RNA recognition motif 329421 Myosin. Large ATPases. ATPase 329421 Myosin. Large ATPases. ATPase 329422 domain in high mobilty group proteins HMG14 and HMG 17 329432 Immunoglobulin 329432 Immunoglobulin C-2 Type 329445 Middle domain of eukaryotic initiation factor 4G (eIF4G) 329445 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 329482 Domain in the Doublecortin (DCX) gene product 329493 high mobility group 329502 Cytoplasmic phospholipase A2, catalytic subunit 329506 catalytic domain of ctd-like phosphatases 329509 Tyrosine kinase, catalytic domain 329509 Serine/Threonine protein kinases, catalytic domain 329516 Tyrosine kinase, catalytic domain 329516 Serine/Threonine protein kinases, catalytic domain 329516 erine/Threonine protein kinases, catalytic domain 329524 Thrombospondin type 1 repeats 329524 Adhesion-associated domain present in MUC4 and other proteins 329533 Actin depolymerisation factor/cofilin -like domains 329547 BPI/LBP/CETP N-terminal domain 329547 BPI/LBP/CETP C-terminal domain 329547 BPI/LBP/CETP N-terminal domain 329574 krueppel associated box 329580 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 329580 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 329581 Baculoviral inhibition of apoptosis protein repeat 329602 Immunoglobulin 329602 Immunoglobulin V-Type 329602 Immunoglobulin C-Type 329602 Immunoglobulin C-2 Type 329655 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 329662 glycine rich nucleic binding domain 329667 Ring finger 329692 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 329693 Immunoglobulin 329693 Immunoglobulin C-2 Type 329714 Histone 2A 329715 Histone 2A 329720 high mobility group 329732 Glyco_18 domain 329757 Ribosomal protein L11/L12 329776 U1-like zinc finger 329786 Ubiquitin homologues 329787 zinc finger 329792 domain present in translation initiation factor eIF2B and eIF5 329841 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 329864 high mobility group 329879 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 329881 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 329882 Interferon alpha, beta and delta 329882 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 329893 RNA recognition motif 329894 RNA recognition motif 329910 in StAR and phosphatidylcholine transfer protein 329917 Immunoglobulin 329917 Immunoglobulin V-Type 329919 Immunoglobulin V-Type 329919 Immunoglobulin 329919 Immunoglobulin V-Type 329928 Broad-Complex, Tramtrack and Bric a brac 329932 Histone H2B 329934 FORKHEAD 329936 glycine rich nucleic binding domain 329941 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 329951 Phosphoinositide 3-kinase, region postulated to contain C2 domain 329955 Ring finger 329959 C2C2 Zinc finger 329959 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 329962 Broad-Complex, Tramtrack and Bric a brac 329963 Chromo Shadow Domain 329963 Chromatin organization modifier domain 329972 EF-hand, calcium binding motif 329977 Forkhead associated domain 329983 K homology RNA-binding domain 329987 glycine rich nucleic binding domain 329991 high mobility group 329996 high mobility group 330005 Calcium-binding EGF-like domain 330012 helicase superfamily c-terminal domain 330015 Helical region found in SNAREs 330020 high mobility group 330042 RNA recognition motif 330048 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 330067 Ring finger 330093 Rab subfamily of small GTPases 330093 Ras subfamily of RAS small GTPases 330093 Rho (Ras homology) subfamily of Ras-like small GTPases 330093 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 330122 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response 330129 bromo domain 330149 DEAD-like helicases superfamily 330160 krueppel associated box 330161 SAND domain 330167 Extension to Ser/Thr-type protein kinases 330167 erine/Threonine protein kinases, catalytic domain 330167 Serine/Threonine protein kinases, catalytic domain 330167 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 330193 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 330207 krueppel associated box 330213 WD40 repeats 330222 Immunoglobulin 330222 Immunoglobulin C-2 Type 330222 Immunoglobulin 330222 Immunoglobulin C-2 Type 330223 Fibronectin type 3 domain 330242 RNA polymerase subunit CX 330272 high mobility group 330294 Immunoglobulin 330294 Immunoglobulin V-Type 330301 krueppel associated box 330301 krueppel associated box 330306 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 330342 Immunoglobulin 330342 Immunoglobulin V-Type 330366 RNA recognition motif 330380 Sec7 domain 330380 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 330396 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 330424 high mobility group 330429 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 330430 Serine/Threonine protein kinases, catalytic domain 330441 high mobility group 330445 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases 330452 high mobility group 330463 krueppel associated box 330466 zinc finger 330470 Fibronectin type 2 domain 330471 Fibronectin type 2 domain 330475 Immunoglobulin 330475 Immunoglobulin C-2 Type 330476 Immunoglobulin 330476 Immunoglobulin C-2 Type 330477 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 330488 Ring finger 330505 Uteroglobin 330506 Uteroglobin 330507 Uteroglobin 330517 glycine rich nucleic binding domain 330519 Trypsin-like serine protease 330539 Laminin G domain 330565 Histone 2A 330616 Domain in SPla and the RYanodine Receptor. 330627 bromo domain 330627 B-Box C-terminal domain 330627 bromo domain 330639 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 330654 Tyrosine kinase, catalytic domain 330654 Serine/Threonine protein kinases, catalytic domain 330657 Trypsin-like serine protease 330662 Src homology 3 domains 330666 domain with conserved PWWP motif 330675 von Willebrand factor (vWF) type D domain 330688 Uteroglobin 330721 Serine/Threonine protein kinases, catalytic domain 330721 Tyrosine kinase, catalytic domain 330721 Serine/Threonine protein kinases, catalytic domain 330723 Kazal type serine protease inhibitors 330723 Insulin growth factor-binding protein homologues 330723 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 330724 PHD zinc finger 330724 associated with SET domains 330724 domain with conserved PWWP motif 330731 Ribosomal RNA adenine dimethylases 330735 Sterile alpha motif 330735 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate 330753 Cadherin repeats 330753 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 330761 high mobility group 330770 ADAM Cysteine-Rich Domain 330770 Homologues of snake disintegrins 330772 DEAD-like helicases superfamily 330788 krueppel associated box 330790 Immunoglobulin 330790 Link (Hyaluronan-binding) 330790 Link (Hyaluronan-binding) 330812 Ring finger 330814 G-protein-coupled receptor proteolytic site domain 330844 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 330863 B-Box-type zinc finger 330891 high mobility group 330892 Laminin G domain 330900 Ubiquitin homologues 330908 Immunoglobulin 330908 Immunoglobulin 330908 Immunoglobulin C-2 Type 330914 GTPase-activator protein for Rho-like GTPases 330914 Src homology 3 domains 330960 Immunoglobulin 330960 Immunoglobulin C-2 Type 330960 Fibronectin type 3 domain 330961 G protein gamma subunit-like motifs 330998 ankyrin repeats 331014 high mobility group 331027 A Receptor for Ubiquitination Targets 331039 14-3-3 homologues 331046 Transglutaminase/protease-like homologues 331049 Lysin motif 331052 Serine/Threonine protein kinases, catalytic domain 331062 Adenylyl- / guanylyl cyclase, catalytic domain 331066 helix loop helix domain 331068 Immunoglobulin 331068 Immunoglobulin V-Type 331069 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 331074 BCL (B-Cell lymphoma) 331080 Immunoglobulin 331080 Immunoglobulin V-Type 331101 RIO-like kinase 331101 Tyrosine kinase, catalytic domain 331101 erine/Threonine protein kinases, catalytic domain 331101 Serine/Threonine protein kinases, catalytic domain 331102 14-3-3 homologues 331145 Pancreatic ribonuclease 331148 Serine/Threonine protein kinases, catalytic domain 331151 Immunoglobulin 331151 Immunoglobulin C-2 Type 331175 Immunoglobulin 331175 Immunoglobulin V-Type 331211 Immunoglobulin C-Type 331224 glycine rich nucleic binding domain 331242 DEAD-like helicases superfamily 331276 Serine/Threonine protein kinases, catalytic domain 331288 Serine/Threonine protein kinases, catalytic domain 331297 Serine/Threonine protein kinases, catalytic domain 331310 Immunoglobulin 331310 Immunoglobulin V-Type 331330 Adenylyl- / guanylyl cyclase, catalytic domain 331355 Immunoglobulin 331355 Immunoglobulin V-Type 331360 leucine rich region 331362 glycine rich nucleic binding domain 331377 Domain present in PSD-95, Dlg, and ZO-1/2 331378 krueppel associated box 331410 snRNP Sm proteins 331414 Found in Pit-Oct-Unc transcription factors 331415 RNA recognition motif 331456 Helical region found in SNAREs 331461 Immunoglobulin 331461 Immunoglobulin C-2 Type 331491 Fibronectin type 3 domain 331494 snRNP Sm proteins 331496 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 331502 Histone 2A 331503 Histone 2A 331505 high mobility group 331507 Low molecular weight phosphatase family 331512 Middle domain of eukaryotic initiation factor 4G (eIF4G) 331523 prohibitin homologues 331535 SERine Proteinase INhibitors 331539 RNA recognition motif 331543 high mobility group 331553 Rab subfamily of small GTPases 331566 Connexin homologues 331611 Ubiquitin associated domain 331615 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 331665 RNA recognition motif 331666 RNA recognition motif 331703 DNA-directed RNA-polymerase II subunit 331708 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 331746 Tyrosine kinase, catalytic domain 331746 Serine/Threonine protein kinases, catalytic domain 331750 Myosin. Large ATPases 331750 Myosin. Large ATPases. ATPase 331807 krueppel associated box 331816 Ribosomal protein L11/L12 331852 RNA recognition motif 331867 Immunoglobulin 331867 Immunoglobulin V-Type 331868 Immunoglobulin 331868 Immunoglobulin V-Type 331869 Immunoglobulin 331869 Immunoglobulin V-Type 331870 Immunoglobulin 331870 Immunoglobulin V-Type 331871 Immunoglobulin 331871 Immunoglobulin V-Type 331872 Immunoglobulin 331872 Immunoglobulin V-Type 331873 Immunoglobulin 331873 Immunoglobulin V-Type 331875 zinc finger 331875 Immunoglobulin 331875 Immunoglobulin V-Type 331876 Immunoglobulin 331876 Immunoglobulin V-Type 331878 Immunoglobulin 331878 Immunoglobulin V-Type 331879 Immunoglobulin 331879 Immunoglobulin V-Type 331880 Immunoglobulin 331880 Immunoglobulin V-Type 331881 Immunoglobulin 331881 Immunoglobulin V-Type 331882 Immunoglobulin 331882 Immunoglobulin V-Type 331883 Immunoglobulin 331883 Immunoglobulin V-Type 331884 Immunoglobulin 331884 Immunoglobulin V-Type 331885 Immunoglobulin 331885 Immunoglobulin V-Type 331887 eukaryotic translation initiation factor 1A 331891 Tyrosine kinase, catalytic domain 331891 Serine/Threonine protein kinases, catalytic domain 331897 RNA recognition motif 331901 Histone H3 331909 Histone H4 331921 prohibitin homologues 331921 SERine Proteinase INhibitors 331923 SERine Proteinase INhibitors 331955 zinc finger 331984 Tyrosine kinase, catalytic domain 331984 Serine/Threonine protein kinases, catalytic domain 331987 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 332004 Tyrosine kinase, catalytic domain 332004 Serine/Threonine protein kinases, catalytic domain 332005 Immunoglobulin 332005 Immunoglobulin V-Type 332060 Immunoglobulin 332060 Immunoglobulin V-Type 332061 high mobility group 332073 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 332078 RNA recognition motif 332109 Ly-6 antigen / uPA receptor -like domain 332110 Serine/Threonine protein kinases, catalytic domain 332110 Tyrosine kinase, catalytic domain 332110 Serine/Threonine protein kinases, catalytic domain 332112 Thymosin beta actin-binding motif 332217 krueppel associated box 332221 leucine rich region 332235 krueppel associated box 332242 domain in high mobilty group proteins HMG14 and HMG 17 332245 ARF-like small GTPases 332245 Rab subfamily of small GTPases 332245 Ras subfamily of RAS small GTPases 332245 Rho (Ras homology) subfamily of Ras-like small GTPases 332245 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 332256 Phosphate acyltransferases 332271 Laminin G domain 332281 WD40 repeats 332342 Lipoxygenase homology 2 (beta barrel) domain 332355 Ubiquitin associated domain 332359 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases 332434 suppressors of cytokine signalling 332450 Domain present in hormone receptors 332474 Trypsin-like serine protease 332499 Coagulation factor 5/8 C-terminal domain, discoidin domain 332560 Serine/Threonine protein kinases, catalytic domain 332597 S4 RNA-binding domain 332626 domain in protein kinases, N-glycanases and other nuclear proteins 332630 Middle domain of eukaryotic initiation factor 4G (eIF4G) 332630 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 332631 Middle domain of eukaryotic initiation factor 4G (eIF4G) 332631 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains 332664 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 332671 RNA recognition motif 332672 high mobility group 332708 krueppel associated box 332709 krueppel associated box 332714 krueppel associated box 332716 krueppel associated box 332718 krueppel associated box 332719 krueppel associated box 332720 krueppel associated box 332722 K homology RNA-binding domain 332723 RNA recognition motif 332738 interferon regulatory factor 332741 GTPase-activator protein for Rho-like GTPases 332775 Immunoglobulin 332775 Immunoglobulin C-2 Type 332778 Low-density lipoprotein receptor domain class A 332790 Ubiquitin homologues 332800 Armadillo/beta-catenin-like repeats 332844 RIO-like kinase 332844 Tyrosine kinase, catalytic domain 332844 erine/Threonine protein kinases, catalytic domain 332844 Serine/Threonine protein kinases, catalytic domain 332881 Rho (Ras homology) subfamily of Ras-like small GTPases 332931 Immunoglobulin V-Type 332947 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 332974 Tyrosine kinase, catalytic domain 332974 Serine/Threonine protein kinases, catalytic domain 332987 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 332993 Ubiquitin homologues 332999 Fibronectin type 3 domain 332999 Protein tyrosine phosphatase, catalytic domain 332999 Protein tyrosine phosphatase, catalytic domain motif 333021 TAF homology 333074 Chromo Shadow Domain 333074 Chromatin organization modifier domain 333116 Immunoglobulin 333116 Immunoglobulin V-Type 333117 Immunoglobulin 333117 Immunoglobulin V-Type 333118 Immunoglobulin 333118 Immunoglobulin V-Type 333119 Immunoglobulin 333119 Immunoglobulin V-Type 333120 Immunoglobulin 333120 Immunoglobulin V-Type 333130 Tyrosine kinase, catalytic domain 333130 Serine/Threonine protein kinases, catalytic domain 333147 Histone H3 333154 Armadillo/beta-catenin-like repeats 333160 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 333162 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 333185 Rab subfamily of small GTPases 333185 Rho (Ras homology) subfamily of Ras-like small GTPases 333224 Ring finger 333253 Tyrosine kinase, catalytic domain 333253 Serine/Threonine protein kinases, catalytic domain 333258 Ring finger 333258 Modified RING finger domain 333261 krueppel associated box 333270 Myosin. Large ATPases. ATPase 333291 associated with SPRY domains 333291 Domain in SPla and the RYanodine Receptor. 333307 Ring finger 333307 B-Box-type zinc finger 333307 Modified RING finger domain 333307 associated with SPRY domains 333307 Domain in SPla and the RYanodine Receptor. 333315 Domains in Na-Ca exchangers and integrin-beta4 333329 Cyclic nucleotide-monophosphate binding domain 333356 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 333384 FORKHEAD 333447 RIO-like kinase 333447 Tyrosine kinase, catalytic domain 333447 Serine/Threonine protein kinases, catalytic domain 333449 Immunoglobulin 333449 Immunoglobulin V-Type 333452 Histone 2A 333455 glycine rich nucleic binding domain 333456 Homeodomain 333460 RIO-like kinase 333460 Tyrosine kinase, catalytic domain 333460 Serine/Threonine protein kinases, catalytic domain 333461 Immunoglobulin 333461 Immunoglobulin V-Type 333466 Immunoglobulin 333466 Immunoglobulin V-Type 333469 Immunoglobulin 333469 Immunoglobulin V-Type 333473 zinc finger 333475 Ubiquitin homologues 333483 Immunoglobulin 333483 Immunoglobulin V-Type 333491 high mobility group 333492 zinc finger 333509 Histone H3 333511 glycine rich nucleic binding domain 333511 Putative single-stranded nucleic acids-binding domain 333536 Histone 2A 333550 high mobility group 333563 Fibronectin type 3 domain 333564 Fibronectin type 3 domain 333573 RNA recognition motif 333616 Immunoglobulin C-Type 333617 Immunoglobulin C-Type 333628 semaphorin domain 333628 domain found in Plexins, Semaphorins and Integrins 333633 bromo domain 333654 ankyrin repeats 333654 Src homology 3 domains 333665 ankyrin repeats 333678 Rab subfamily of small GTPases 333679 krueppel associated box 333685 Immunoglobulin 333685 Immunoglobulin V-Type 333687 Immunoglobulin 333687 Immunoglobulin V-Type 333688 Immunoglobulin 333688 Immunoglobulin V-Type 333689 Immunoglobulin 333689 Immunoglobulin V-Type 333690 Immunoglobulin 333690 Immunoglobulin V-Type 333691 Immunoglobulin 333691 Immunoglobulin V-Type 333692 Immunoglobulin 333692 Immunoglobulin V-Type 333693 Immunoglobulin 333693 Immunoglobulin V-Type 333694 Immunoglobulin 333694 Immunoglobulin V-Type 333695 Immunoglobulin 333695 Immunoglobulin V-Type 333695 Immunoglobulin C-2 Type 333697 Immunoglobulin 333697 Immunoglobulin V-Type 333698 Immunoglobulin 333698 Immunoglobulin V-Type 333699 Immunoglobulin 333699 Immunoglobulin V-Type 333708 WD40 repeats 333709 Immunoglobulin C-Type 333711 Immunoglobulin C-Type 333715 Immunoglobulin C-Type 333715 Immunoglobulin C-Type 333716 RIO-like kinase 333716 Ubiquitin associated domain 333716 Tyrosine kinase, catalytic domain 333716 Serine/Threonine protein kinases, catalytic domain 333717 Galectin 333719 Homeodomain 333721 Immunoglobulin C-Type 333728 Immunoglobulin C-Type 333730 B-Box-type zinc finger 333732 Immunoglobulin C-Type 333734 Immunoglobulin 333734 Immunoglobulin V-Type 333741 Immunoglobulin C-Type 333742 Immunoglobulin C-Type 333745 Immunoglobulin C-Type 333746 Immunoglobulin C-Type 333747 Immunoglobulin C-Type 333756 minichromosome maintenance proteins 333758 krueppel associated box 333767 Domain in the Doublecortin (DCX) gene product 333778 von Willebrand factor (vWF) type D domain 333783 GTPase-activator protein for Rho-like GTPases 333788 Rab subfamily of small GTPases 333788 Ras subfamily of RAS small GTPases 333788 Rho (Ras homology) subfamily of Ras-like small GTPases 333788 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 333791 Immunoglobulin 333791 Immunoglobulin V-Type 333797 krueppel associated box 333827 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase 333834 ARID (A/T-rich interaction domain) domain 333834 Small domain found in the jumonji family of transcription factors 333849 Immunoglobulin 333849 Immunoglobulin V-Type 333850 Immunoglobulin 333850 Immunoglobulin V-Type 333851 Immunoglobulin 333851 Immunoglobulin V-Type 333852 Immunoglobulin 333852 Immunoglobulin V-Type 333854 Immunoglobulin 333854 Immunoglobulin V-Type 333855 Immunoglobulin 333855 Immunoglobulin V-Type 333856 Immunoglobulin 333856 Immunoglobulin V-Type 333857 Immunoglobulin 333857 Immunoglobulin V-Type 333858 Immunoglobulin 333858 Immunoglobulin V-Type 333859 Immunoglobulin 333859 Immunoglobulin V-Type 333862 Immunoglobulin C-Type 333866 Histone H3 333869 Ubiquitin associated domain 333872 Ring finger 333883 Ly-6 antigen / uPA receptor -like domain 333883 Ly-6 antigen / uPA receptor -like domain 333886 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) 333895 Immunoglobulin V-Type 333896 Immunoglobulin V-Type 333897 Immunoglobulin 333897 Immunoglobulin V-Type 333898 Immunoglobulin 333898 Immunoglobulin V-Type 333899 Immunoglobulin 333899 Immunoglobulin V-Type 333902 Immunoglobulin 333902 Immunoglobulin V-Type 333903 Immunoglobulin 333903 Immunoglobulin V-Type 333926 Serine/threonine phosphatases, family 2C, catalytic domain 338321 Leucine rich repeat, ribonuclease inhibitor type 338352 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin 338355 WASP homology region 1 338356 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 338367 Myosin. Large ATPases. ATPase 338368 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 338372 Src homology 3 domains 338372 Tyrosine kinase, catalytic domain 338382 Rab subfamily of small GTPases 338477 Src homology 2 domains 338477 Src homology 3 domains 338523 A domain family that is part of the cupin metalloenzyme superfamily 338554 domain in DSRM or ZnF_C2H2 domain containing proteins 338563 Serine/Threonine protein kinases, catalytic domain 338599 Dual specificity phosphatase, catalytic domain 338599 Protein tyrosine phosphatase, catalytic domain motif 338614 helix loop helix domain 338619 RNA recognition motif 338623 FORKHEAD 338642 Olfactomedin-like domains 338649 Ribosomal protein L11/L12 338660 Homeodomain 338682 Protein kinase C conserved region 2 (CalB) 338692 ankyrin repeats 338699 ankyrin repeats 338736 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met 338757 Fibronectin type 3 domain 338757 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 338761 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 338806 ARF-like small GTPases 338806 Sar1p-like members of the Ras-family of small GTPases 338812 DEAD-like helicases superfamily 338812 helicase superfamily c-terminal domain 338815 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 338821 Kazal type serine protease inhibitors 338829 Fibronectin type 3 domain 338830 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 338831 JAB/MPN domain 338834 Src homology 3 domains 338835 Tyrosine kinase, catalytic domain 338835 Serine/Threonine protein kinases, catalytic domain 338871 DEAD-like helicases superfamily 338872 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t 338872 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 338879 Pancreatic ribonuclease 338903 domain in DSRM or ZnF_C2H2 domain containing proteins 338912 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 338913 ADAM Cysteine-Rich Domain 338913 Homologues of snake disintegrins 338921 WD40 repeats 338972 ATPases associated with a variety of cellular activities 338973 Cyclic nucleotide-monophosphate binding domain 339010 ankyrin repeats 339039 Leucine rich repeat C-terminal domain 339039 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 339039 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 339039 present in yeast cell wall integrity and stress response component proteins 339044 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 339044 Repeats in polycystic kidney disease 1 (PKD1) and other proteins 339086 Phospholipase A2 339102 Trypsin-like serine protease 339105 Trypsin-like serine protease 339106 Immunoglobulin 339106 Immunoglobulin V-Type 339115 Immunoglobulin 339115 Immunoglobulin V-Type 339120 Immunoglobulin 339120 Immunoglobulin V-Type 339122 ARF-like small GTPases 339122 Rab subfamily of small GTPases 339122 Ras subfamily of RAS small GTPases 339122 Rho (Ras homology) subfamily of Ras-like small GTPases 339122 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 339133 Immunoglobulin 339133 Immunoglobulin V-Type 339133 ADAM Cysteine-Rich Domain 339133 Homologues of snake disintegrins 339162 RRM_1 domain 339162 RNA recognition motif 339173 Tyrosine kinase, catalytic domain 339173 Serine/Threonine protein kinases, catalytic domain 339212 Tyrosine kinase, catalytic domain 339212 Serine/Threonine protein kinases, catalytic domain 339231 ARF-like small GTPases 339231 Sar1p-like members of the Ras-family of small GTPases 339237 Spectrin repeats 339246 Middle domain of eukaryotic initiation factor 4G (eIF4G) 339319 von Willebrand factor (vWF) type D domain 339319 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins 339320 von Willebrand factor (vWF) type D domain 339321 erythroblast transformation specific domain 339327 krueppel associated box 339327 krueppel associated box 339340 Immunoglobulin 339340 Immunoglobulin C-2 Type 339347 Fibronectin type 2 domain 339358 semaphorin domain 339371 krueppel associated box 339377 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 339389 krueppel associated box 339390 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 339398 Immunoglobulin 339398 Immunoglobulin C-2 Type 339423 RNA recognition motif 339451 Broad-Complex, Tramtrack and Bric a brac 339452 Kazal type serine protease inhibitors 339452 Laminin-type epidermal growth factor-like domai 339452 Domain found in sea urchin sperm protein, enterokinase, agrin 339479 membrane-attack complex / perforin 339489 Tyrosine kinase, catalytic domain 339489 Serine/Threonine protein kinases, catalytic domain 339492 Inositol polyphosphate phosphatase, catalytic domain homologues 339501 Trypsin-like serine protease 339521 domain present in cyclins, TFIIB and Retinoblastoma 339559 leucine rich region 339559 krueppel associated box 339562 Immunoglobulin 339562 Immunoglobulin V-Type 339562 Immunoglobulin C-2 Type 339581 Ubiquitin homologues 339604 Cystatin-like domain 339628 WD40 repeats 339672 S4 RNA-binding domain 339715 krueppel associated box 339726 Immunoglobulin 339726 Immunoglobulin V-Type 339737 Histone 2A 339744 meprin and TRAF homology 339745 Broad-Complex, Tramtrack and Bric a brac 339746 Immunoglobulin V-Type 339747 Actin 339749 Ran-binding domain 339752 Homeodomain 339772 DnaJ molecular chaperone homology domain 339799 JAB/MPN domain 339839 krueppel associated box 339843 Domain with 2 conserved Trp (W) residues 339843 Protein kinase C conserved region 2 (CalB) 339843 Domain Homologous to E6-AP Carboxyl Terminus with 339855 Transglutaminase/protease-like homologues 339881 RNA recognition motif 339892 Caspase recruitment domain 339903 krueppel associated box 339906 Trypsin-like serine protease 339906 Trypsin-like serine protease 339909 Immunoglobulin 339909 Immunoglobulin C-2 Type 339909 Leucine rich repeat C-terminal domain 339943 Serine/Threonine protein kinases, catalytic domain 339951 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 339966 Ubiquitin homologues 339967 Trypsin-like serine protease 339967 Trypsin-like serine protease 339968 Trypsin-like serine protease 339976 associated with SPRY domains 339976 Ring finger 339976 associated with SPRY domains 339976 Domain in SPla and the RYanodine Receptor. 339994 Homologues of snake disintegrins 340049 FORKHEAD 340055 CDGSH-type zinc finger. Function unknown 340066 domain in high mobilty group proteins HMG14 and HMG 17 340096 Histone H3 340120 ankyrin repeats 340133 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 340147 DnaJ molecular chaperone homology domain 340156 Serine/Threonine protein kinases, catalytic domain 340163 N-terminal to some SET domains 340189 RNA recognition motif 340204 Colipase 340217 Homeodomain 340221 Bromo adjacent homology domain 340248 krueppel associated box 340252 krueppel associated box 340252 krueppel associated box 340260 Homeodomain 340265 Formin Homology 2 Domain 340265 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 340273 ATPases associated with a variety of cellular activities 340289 Ubiquitin homologues 340289 erythroblast transformation specific domain 340312 Armadillo/beta-catenin-like repeats 340326 Armadillo/beta-catenin-like repeats 340351 Zn_pept domain 340354 Domain in the Doublecortin (DCX) gene product 340359 Kelch domain 340359 Broad-Complex, Tramtrack and Bric a brac 340361 Homeodomain 340361 Found in Pit-Oct-Unc transcription factors 340368 Domain in SPla and the RYanodine Receptor. 340386 Ribosomal protein L11/L12 340406 krueppel associated box 340413 Scavenger receptor Cys-rich 340416 Calponin homology domain 340417 Thymosin beta actin-binding motif 340426 Lipoxygenase homology 2 (beta barrel) domain 340433 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 340441 ankyrin repeats 340449 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases 340452 Transforming growth factor-beta (TGF-beta) family 340458 Homeodomain 340487 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 340488 Histone H3 340493 RRM_1 domain 340493 RNA recognition motif 340499 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 340501 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) 340501 Domain in the central regions of transcription elongation factor S-II (and elsewhere) 340518 Lipoxygenase homology 2 (beta barrel) domain 340529 RNA recognition motif 340530 RNA recognition motif 340532 Ring finger 340539 Ubiquitin homologues 340546 Histidine kinase-like ATPases 340547 Immunoglobulin 340547 Immunoglobulin 340547 Immunoglobulin V-Type 340547 Immunoglobulin C-2 Type 340549 Histone 2A 340561 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 340567 K homology RNA-binding domain 340567 DEAD-like helicases superfamily 340567 helicase superfamily c-terminal domain 340573 high mobility group 340574 Histone 2A 340578 WD40 repeats 340593 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 340600 basic region leucin zipper 340628 RNA recognition motif 340644 Ring finger 340647 Protein kinase C conserved region 2 (CalB) 340663 DEAD-like helicases superfamily 340663 helicase superfamily c-terminal domain 340680 high mobility group 340697 high mobility group 340699 U1-like zinc finger 340699 RNA recognition motif 340706 Calcium-binding EGF-like domain 340706 Epidermal growth factor-like domain 340706 von Willebrand factor (vWF) type A domain 340706 Serine/Threonine protein kinases, catalytic domain 340733 Dual specificity phosphatase, catalytic domain 340734 Papain family cysteine protease 340735 Cold shock protein domain 340736 Papain family cysteine protease 340745 Immunoglobulin 340745 Immunoglobulin C-2 Type 340745 Leucine rich repeat C-terminal domain 340753 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 340757 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product 340765 Homeodomain 340768 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 340769 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 340778 Papain family cysteine protease 340780 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass 340784 Homeodomain 340835 Broad-Complex, Tramtrack and Bric a brac 340840 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 340846 Dual specificity phosphatase, catalytic domain 340847 Papain family cysteine protease 340852 Dual specificity phosphatase, catalytic domain 340859 Papain family cysteine protease 340861 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 340874 ARF-like small GTPases 340874 Rab subfamily of small GTPases 340874 Ras subfamily of RAS small GTPases 340874 Sar1p-like members of the Ras-family of small GTPases 340874 Rho (Ras homology) subfamily of Ras-like small GTPases 340896 Low-density lipoprotein receptor domain class A 340896 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) 340968 Serine/Threonine protein kinases, catalytic domain 340970 Ring finger 340970 Domain in SPla and the RYanodine Receptor. 340977 Band 4.1 homologues 340996 high mobility group 341002 krueppel associated box 341009 Chromo Shadow Domain 341009 Chromatin organization modifier domain 341019 Domain in the Doublecortin (DCX) gene product 341019 Domain in the Doublecortin (DCX) gene product 341094 Immunoglobulin 341094 Immunoglobulin C-2 Type 341135 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 341147 DnaJ molecular chaperone homology domain 341168 RNA recognition motif 341172 high mobility group 341180 Domain in SPla and the RYanodine Receptor. 341201 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 341225 Caspase recruitment domain 341277 Trypsin-like serine protease 341277 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 341287 Rab subfamily of small GTPases 341287 Ras subfamily of RAS small GTPases 341287 Rho (Ras homology) subfamily of Ras-like small GTPases 341301 krueppel associated box 341315 RNA recognition motif 341315 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 341350 Trypsin-like serine protease 341350 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 341359 Protein kinase C conserved region 2 (CalB) 341383 Ring finger 341383 associated with SPRY domains 341383 Domain in SPla and the RYanodine Receptor. 341399 krueppel associated box 341409 DEAD-like helicases superfamily 341409 helicase superfamily c-terminal domain 341415 heat shock factor 341549 Ring finger 341549 Modified RING finger domain 341549 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 341555 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK 341558 Homeodomain 341560 ARID (A/T-rich interaction domain) domain 341565 Ubiquitin homologues 341583 bromo domain 341643 EF-hand, calcium binding motif 341676 Tyrosine kinase, catalytic domain 341676 Serine/Threonine protein kinases, catalytic domain 341680 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 341722 Double-stranded RNA binding motif 341752 ankyrin repeats 341753 Domain associated with PX domains 341761 RNA recognition motif 341784 DEAD-like helicases superfamily 341795 GTPase-activator protein for Rho-like GTPases 341803 Pancreatic ribonuclease 341816 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 341834 DnaJ molecular chaperone homology domain 341845 14-3-3 homologues 341858 G protein gamma subunit-like motifs 341864 domain in high mobilty group proteins HMG14 and HMG 17 341894 domain present in translation initiation factor eIF2B and eIF5 341899 high mobility group 341902 ADAM Cysteine-Rich Domain 341902 Homologues of snake disintegrins 341905 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 341973 Rab subfamily of small GTPases 341973 Ras subfamily of RAS small GTPases 341974 Rab subfamily of small GTPases 341974 Ras subfamily of RAS small GTPases 342013 ankyrin repeats 342035 Olfactomedin-like domains 342052 DEAD-like helicases superfamily 342052 helicase superfamily c-terminal domain 342072 Cold shock protein domain 342101 RNA recognition motif 342111 Laminin G domain 342116 RNA recognition motif 342138 Actin depolymerisation factor/cofilin -like domains 342155 ATPases associated with a variety of cellular activities 342184 Formin Homology 2 Domain 342209 ATPases associated with a variety of cellular activities 342229 Immunoglobulin 342229 Immunoglobulin V-Type 342230 Immunoglobulin 342230 Immunoglobulin V-Type 342231 Immunoglobulin V-Type 342253 Src homology 3 domains 342289 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 342315 prohibitin homologues 342357 leucine rich region 342357 krueppel associated box 342371 Hint (Hedgehog/Intein) domain N-terminal region 342371 domain in Ataxins and HMG containing proteins 342372 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 342372 Lipoxygenase homology 2 (beta barrel) domain 342372 G-protein-coupled receptor proteolytic site domain 342409 Homeodomain 342418 Thrombospondin type 1 repeats 342423 Filamin-type immunoglobulin domains 342427 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 342429 Immunoglobulin 342429 Immunoglobulin V-Type 342432 Homeodomain 342443 Immunoglobulin 342443 Immunoglobulin V-Type 342443 ADAM Cysteine-Rich Domain 342443 Homologues of snake disintegrins 342444 Immunoglobulin 342444 Immunoglobulin V-Type 342504 zinc finger 342509 Immunoglobulin 342510 Immunoglobulin 342527 Calponin homology domain 342531 Lipoxygenase homology 2 (beta barrel) domain 342543 bromo domain 342550 Ubiquitin homologues 342565 krueppel associated box 342578 high mobility group 342626 Tyrosine kinase, catalytic domain 342626 Serine/Threonine protein kinases, catalytic domain 342636 Trypsin-like serine protease 342660 Immunoglobulin 342660 Immunoglobulin C-2 Type 342661 14-3-3 homologues 342662 Protein kinase C conserved region 2 (CalB) 342667 Src homology 3 domains 342667 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 342669 Leucine-rich repeats, typical (most populated) subfamily 342705 Epsin N-terminal homology (ENTH) domain 342827 Domain associated with PX domains 342854 ankyrin repeats 342865 Immunoglobulin 342865 Immunoglobulin V-Type 342883 leucine rich region 342888 Tyrosine kinase, catalytic domain 342888 Serine/Threonine protein kinases, catalytic domain 342892 krueppel associated box 342894 krueppel associated box 342900 Homeodomain 342905 RNA recognition motif 342908 krueppel associated box 342917 krueppel associated box 342923 krueppel associated box 342926 krueppel associated box 342926 krueppel associated box 342931 associated with SPRY domains 342931 Domain in SPla and the RYanodine Receptor. 342933 leucine rich region 342934 leucine rich region 342938 krueppel associated box 342939 Homeodomain 342945 leucine rich region 342945 leucine rich region 342969 krueppel associated box 342970 krueppel associated box 342972 krueppel associated box 342982 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 342989 krueppel associated box 342990 krueppel associated box 342991 krueppel associated box 343011 Chitin-binding domain type 2 343018 c4 zinc finger in nuclear hormone receptors 343019 RNA recognition motif 343024 Domain abundant in complement control proteins 343059 erythroblast transformation specific domain 343069 RNA recognition motif 343085 high mobility group 343094 B-Box-type zinc finger 343095 B-Box C-terminal domain 343095 Fibronectin type 3 domain 343095 Domain in SPla and the RYanodine Receptor. 343128 ARF-like small GTPases 343128 Sar1p-like members of the Ras-family of small GTPases 343161 high mobility group 343164 krueppel associated box 343176 Histone H2B 343186 Actin depolymerisation factor/cofilin -like domains 343190 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 343205 prohibitin homologues 343230 RNA recognition motif 343230 K homology RNA-binding domain 343232 Domain in the RNA-binding Lupus La protein 343263 Immunoglobulin 343263 Immunoglobulin C-2 Type 343263 Fibronectin type 3 domain 343290 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 343297 RNA recognition motif 343342 Domain abundant in complement control proteins 343342 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 343353 prohibitin homologues 343413 Immunoglobulin 343413 Immunoglobulin C-2 Type 343472 Homeodomain 343489 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 343492 K homology RNA-binding domain 343549 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 343552 FORKHEAD 343574 domain in TBC and LysM domain containing proteins 343578 GTPase-activator protein for Rho-like GTPases 343587 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 343591 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 343593 krueppel associated box 343638 Immunoglobulin 343638 Immunoglobulin C-Type 343641 Transglutaminase/protease-like homologues 343651 RNA recognition motif 343654 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 343699 Immunoglobulin 343701 interferon regulatory factor 343708 high mobility group 343750 DEAD-like helicases superfamily 343822 ankyrin repeats 343824 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 343831 Serine/Threonine protein kinases, catalytic domain 343839 Immunoglobulin C-Type 343868 Calponin homology domain 343870 Immunoglobulin 343870 Immunoglobulin V-Type 343870 Immunoglobulin C-Type 343875 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 343876 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 343930 helix loop helix domain 343943 WD40 repeats 343948 Immunoglobulin 343948 Immunoglobulin V-Type 343948 Immunoglobulin C-2 Type 343974 Domain in the Doublecortin (DCX) gene product 344018 helix loop helix domain 344022 Homeodomain 344056 DnaJ molecular chaperone homology domain 344151 K homology RNA-binding domain 344152 Ubiquitin homologues 344167 FORKHEAD 344171 Ubiquitin homologues 344190 Thymosin beta actin-binding motif 344191 Homeodomain 344254 Chromo Shadow Domain 344254 Chromatin organization modifier domain 344284 Homeodomain 344286 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 344287 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway 344382 WD40 repeats 344387 Tyrosine kinase, catalytic domain 344387 Serine/Threonine protein kinases, catalytic domain 344394 Beta/gamma crystallins 344424 RNA recognition motif 344431 RNA recognition motif 344471 Ribosomal protein L11/L12 344473 Beta/gamma crystallins 344474 Armadillo/beta-catenin-like repeats 344498 Immunoglobulin 344498 Immunoglobulin C-2 Type 344498 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif 344554 Ring finger 344557 Src homology 3 domains 344558 Src homology 3 domains 344565 Src homology 2 domains 344574 GTPase-activator protein for Rho-like GTPases 344593 Src homology 2 domains 344593 Protein tyrosine phosphatase, catalytic domain 344593 Protein tyrosine phosphatase, catalytic domain motif 344620 WD40 repeats 344622 Beta/gamma crystallins 344631 Helical region found in SNAREs 344658 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat 344694 high mobility group 344697 RNA recognition motif 344700 Immunoglobulin 344700 Immunoglobulin V-Type 344702 Homeodomain 344707 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 344715 Immunoglobulin 344715 Immunoglobulin C-2 Type 344726 Src homology 3 domains 344741 RNA recognition motif 344758 DEAD-like helicases superfamily 344758 helicase superfamily c-terminal domain 344787 krueppel associated box 344805 Trypsin-like serine protease 344805 Low-density lipoprotein receptor domain class A 344805 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 344819 leucine rich region 344819 krueppel associated box 344820 Src homology 2 domains 344820 suppressors of cytokine signalling 344875 von Willebrand factor (vWF) type A domain 344890 ankyrin repeats 344936 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 344944 domain in DSRM or ZnF_C2H2 domain containing proteins 344978 Spectrin repeats 344988 ARF-like small GTPases 344988 G protein alpha subunit 344988 Sar1p-like members of the Ras-family of small GTPases 345028 Histidine kinase-like ATPases 345062 Trypsin-like serine protease 345079 ankyrin repeats 345083 RNA recognition motif 345100 Trypsin-like serine protease 345100 Protein kinase C conserved region 2 (CalB) 345101 Trypsin-like serine protease 345101 Domain found in sea urchin sperm protein, enterokinase, agrin 345121 GTPase-activator protein for Rho-like GTPases 345131 helix loop helix domain 345157 Histidine kinase-like ATPases 345192 RNA recognition motif 345193 Immunoglobulin 345193 Immunoglobulin C-2 Type 345193 Fibronectin type 3 domain 345288 serum albumin 345305 Broad-Complex, Tramtrack and Bric a brac 345310 ARF-like small GTPases 345310 Rab subfamily of small GTPases 345310 Ras subfamily of RAS small GTPases 345310 Rho (Ras homology) subfamily of Ras-like small GTPases 345310 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 345348 Found in Skp1 protein family 345372 helicase superfamily c-terminal domain 345443 RNA recognition motif 345462 krueppel associated box 345463 Cold shock protein domain 345547 Kazal type serine protease inhibitors 345557 Phospholipase C, catalytic domain (part) 345571 domain involved in Ras-like GTPase signaling 345571 Protein present in Fab1, YOTB, Vac1, and EEA1 345645 ATPases associated with a variety of cellular activities 345711 ankyrin repeats 345761 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 345774 high mobility group 345781 RNA recognition motif 345783 Ubiquitin homologues 345818 RNA recognition motif 345820 Cullin 345864 Cold shock protein domain 345874 Rab subfamily of small GTPases 345882 glycine rich nucleic binding domain 345893 Chromo Shadow Domain 345893 Chromatin organization modifier domain 345923 high mobility group 345930 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 345993 RNA recognition motif 346004 Laminin G domain 346005 Laminin G domain 346005 Calcium-binding EGF-like domain 346005 Epidermal growth factor-like domain 346012 Thymosin beta actin-binding motif 346033 high mobility group 346036 Armadillo/beta-catenin-like repeats 346042 Connexin homologues 346072 Kringle domain 346149 Histone H2B 346150 Histone H3 346162 leucine rich region 346171 krueppel associated box 346172 Ring finger 346177 EF-hand, calcium binding motif 346190 ARF-like small GTPases 346190 Rab subfamily of small GTPases 346190 Ras subfamily of RAS small GTPases 346190 Sar1p-like members of the Ras-family of small GTPases 346190 Rho (Ras homology) subfamily of Ras-like small GTPases 346190 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 346191 Ribosomal protein L11/L12 346239 Calponin homology domain 346252 krueppel associated box 346270 Immunoglobulin 346270 Immunoglobulin C-2 Type 346284 Contains two conserved F residues 346284 GTPase-activator protein for Rho-like GTPases 346286 Rab subfamily of small GTPases 346286 Ras subfamily of RAS small GTPases 346286 Rho (Ras homology) subfamily of Ras-like small GTPases 346286 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 346295 14-3-3 homologues 346319 krueppel associated box 346329 G protein alpha subunit 346355 Leucine rich repeat C-terminal domain 346359 Immunoglobulin 346359 Immunoglobulin C-2 Type 346373 Domain in the RNA-binding Lupus La protein 346402 Ribosomal protein L11/L12 346404 ATPases associated with a variety of cellular activities 346412 Ubiquitin homologues 346416 high mobility group 346454 Tyrosine kinase, catalytic domain 346454 Serine/Threonine protein kinases, catalytic domain 346463 high mobility group 346472 RNA recognition motif 346476 ARF-like small GTPases 346476 Rab subfamily of small GTPases 346476 Ras subfamily of RAS small GTPases 346476 Rho (Ras homology) subfamily of Ras-like small GTPases 346476 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 346540 Actin 346542 Tyrosine kinase, catalytic domain 346542 Serine/Threonine protein kinases, catalytic domain 346562 ARF-like small GTPases 346562 G protein alpha subunit 346565 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 346671 In Between Ring fingers 346689 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 346702 Trypsin-like serine protease 346707 krueppel associated box 346713 Wnt-inhibitory factor-1 like domain 346722 Protein kinase C conserved region 2 (CalB) 346723 ARF-like small GTPases 346723 Sar1p-like members of the Ras-family of small GTPases 346730 krueppel associated box 346762 Serine/Threonine protein kinases, catalytic domain 346802 krueppel associated box 346894 Serine/Threonine protein kinases, catalytic domain 346904 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 346905 Domain abundant in complement control proteins 346905 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 346988 BAG domains, present in regulator of Hsp70 proteins 346989 Ubiquitin homologues 346990 Histone 2A 346998 ankyrin repeats 347031 Rab subfamily of small GTPases 347085 RNA recognition motif 347088 Pentraxin / C-reactive protein / pentaxin family 347088 G-protein-coupled receptor proteolytic site domain 347088 Pentraxin / C-reactive protein / pentaxin family 347088 G-protein-coupled receptor proteolytic site domain 347115 FORKHEAD 347177 RNA recognition motif 347207 Serine/Threonine protein kinases, catalytic domain 347218 K homology RNA-binding domain 347240 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 347241 krueppel associated box 347252 Immunoglobulin 347252 Immunoglobulin C-2 Type 347252 Kazal type serine protease inhibitors 347295 Cold shock protein domain 347305 Serine/Threonine protein kinases, catalytic domain 347319 Protein tyrosine phosphatase, catalytic domain 347319 Protein tyrosine phosphatase, catalytic domain motif 347336 RNA recognition motif 347344 krueppel associated box 347345 krueppel associated box 347358 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. Domain in SET domain containing proteins and in Deinococcus radiodurans DRA1533 347362 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) 347363 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 347365 Vault protein Inter-alpha-Trypsin domain 347365 von Willebrand factor (vWF) type A domain 347376 Histone H3 347392 Histone H2B 347393 Histone H2B 347393 erythroblast transformation specific domain 347395 Histone H2B 347418 RNA recognition motif 347421 domain present in cyclins, TFIIB and Retinoblastoma 347428 Tetratricopeptide repeats 347442 WD40 repeats 347480 domain in splicing factors 347498 Chromatin organization modifier domain 347512 heat shock factor 347517 ARF-like small GTPases 347517 Rab subfamily of small GTPases 347517 Ras subfamily of RAS small GTPases 347517 Rho (Ras homology) subfamily of Ras-like small GTPases 347517 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 347572 Four-disulfide core domains 347583 RNA recognition motif 347598 RNA recognition motif 347598 Trypsin-like serine protease 347604 RNA recognition motif 347613 Vault protein Inter-alpha-Trypsin domain 347617 ARF-like small GTPases 347617 Sar1p-like members of the Ras-family of small GTPases 347636 krueppel associated box 347644 krueppel associated box 347649 Immunoglobulin C-Type 347660 krueppel associated box 347663 Ring finger 347670 EF-hand, calcium binding motif 347722 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted 347722 ankyrin repeats 347722 Rab subfamily of small GTPases 347722 Ras subfamily of RAS small GTPases 347722 Putative GTP-ase activating proteins for the small GTPase, ARF 347722 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 347736 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 347754 Homeodomain 347755 Homeodomain 347756 Homeodomain 347757 Homeodomain 347766 Rab subfamily of small GTPases 347766 Ras subfamily of RAS small GTPases 347773 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 347784 Homeodomain 347785 Homeodomain 347787 Homeodomain 347788 Homeodomain 347789 Homeodomain 347790 Homeodomain 347791 Homeodomain 347792 Homeodomain 347801 G protein alpha subunit 347808 krueppel associated box 347809 RNA recognition motif 347853 Domain first found in the mice T locus (Brachyury) protein 347853 Domain first found in the mice T locus (Brachyury) protein 347859 RNA recognition motif 347867 Ring finger 347868 Domain in SPla and the RYanodine Receptor. 347869 Domain in SPla and the RYanodine Receptor. 347870 Domain in SPla and the RYanodine Receptor. 347873 RRM_1 domain 347873 RNA recognition motif 347876 Serum amyloid A proteins 347878 krueppel associated box 347902 Immunoglobulin 347902 Immunoglobulin 347902 Immunoglobulin C-2 Type 347904 prohibitin homologues 347915 14-3-3 homologues 347922 helicase superfamily c-terminal domain 347925 RRM_1 domain 347925 RNA recognition motif 347930 helix loop helix domain 347931 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 347937 tob/btg1 family 347948 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 347961 DEAD-like helicases superfamily 347966 Galectin 347967 Histone 2A 347970 RNA polymerase subunit CX 347974 ARF-like small GTPases 347974 Sar1p-like members of the Ras-family of small GTPases 347975 Homeodomain 347980 Immunoglobulin C-Type 347994 ARF-like small GTPases 347994 Sar1p-like members of the Ras-family of small GTPases 348000 Immunoglobulin C-Type 348004 Immunoglobulin C-Type 348005 Ring finger 348019 Calponin homology domain 348029 Actin 348033 Immunoglobulin 348033 Immunoglobulin V-Type 348034 Immunoglobulin 348034 Immunoglobulin V-Type 348040 Guanine nucleotide exchange factor for Ras-like GTPases 348040 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d 348079 RRM_1 domain 348079 glycine rich nucleic binding domain 348093 RNA recognition motif 348095 Kelch domain 348095 Broad-Complex, Tramtrack and Bric a brac 348104 ankyrin repeats 348111 RNA recognition motif 348114 ADAM Cysteine-Rich Domain 348114 Homologues of snake disintegrins 348146 Src homology 3 domains 348148 Cyclic nucleotide-monophosphate binding domain 348174 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 348174 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no 348189 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 348191 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 348200 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 348201 RNA recognition motif 348205 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu 348214 helix loop helix domain 348215 helicase superfamily c-terminal domain 348217 Ring finger 348224 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 348243 Galectin 348245 Dual specificity phosphatase, catalytic domain 348250 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 348257 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 348263 ankyrin repeats 348271 Immunoglobulin V-Type 348277 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 348283 minichromosome maintenance proteins 348285 Ribosomal protein L11/L12 348296 Ribosomal protein L11/L12 348321 krueppel associated box 348327 krueppel associated box 348327 krueppel associated box 348331 Trypsin-like serine protease 348354 krueppel associated box 348356 Immunoglobulin 348356 Immunoglobulin C-2 Type 348365 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw 348380 DnaJ molecular chaperone homology domain 348402 GTPase-activator protein for Rho-like GTPases 348402 Inositol polyphosphate phosphatase, catalytic domain homologues 348419 Histidine kinase-like ATPases 348447 Fes/CIP4 homology domain 348464 DEAD-like helicases superfamily 348478 Rab subfamily of small GTPases 348478 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 348479 Ring finger 348526 PB1 domain 348589 Domain found in sea urchin sperm protein, enterokinase, agrin 348600 Phosphoinositide 3-kinase, catalytic domain 348607 GTPase-activator protein for Rho-like GTPases 348619 ARF-like small GTPases 348619 Rab subfamily of small GTPases 348619 Sar1p-like members of the Ras-family of small GTPases 348664 Immunoglobulin 348664 Immunoglobulin V-Type 348675 RNA recognition motif 348720 PHD zinc finger 348722 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 348731 ankyrin repeats 348746 RNA recognition motif 348757 high mobility group 348769 PHD zinc finger 348775 glycine rich nucleic binding domain 348778 RNA recognition motif 348793 WD40 repeats 348811 high mobility group 348822 Dual specificity phosphatase, catalytic domain 348829 Ubiquitin homologues 348836 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium 348858 Histone H3 348872 domain in high mobilty group proteins HMG14 and HMG 17 348876 ADAM Cysteine-Rich Domain 348895 RNA recognition motif 348896 Immunoglobulin C-Type 348909 krueppel associated box 348916 RNA recognition motif 348935 Histone H3 348949 DEAD-like helicases superfamily 348949 helicase superfamily c-terminal domain 348952 krueppel associated box 348953 high mobility group 348955 DEAD-like helicases superfamily 348965 Rhodanese Homology Domain 348975 Histone H3 348980 Cyclic nucleotide-monophosphate binding domain 349013 ATPases associated with a variety of cellular activities 349018 Rab subfamily of small GTPases 349018 Rho (Ras homology) subfamily of Ras-like small GTPases 349020 Rab subfamily of small GTPases 349020 Ras subfamily of RAS small GTPases 349020 Rho (Ras homology) subfamily of Ras-like small GTPases 349029 Rab subfamily of small GTPases 349029 Rho (Ras homology) subfamily of Ras-like small GTPases 349044 Immunoglobulin C-Type 349065 Tyrosine kinase, catalytic domain 349065 Serine/Threonine protein kinases, catalytic domain 349073 EF-hand, calcium binding motif 349075 krueppel associated box 349075 krueppel associated box 349084 Phosphatidylinositol phosphate kinases 349136 WD40 repeats 349141 Ubiquitin associated domain 349143 ARF-like small GTPases 349143 Rab subfamily of small GTPases 349143 Sar1p-like members of the Ras-family of small GTPases 349146 Armadillo/beta-catenin-like repeats 349149 Connexin homologues 349158 krueppel associated box 349206 Found in Pit-Oct-Unc transcription factors 349233 Cyclic nucleotide-monophosphate binding domain 349234 Cyclic nucleotide-monophosphate binding domain 349254 Laminin G domain 349258 krueppel associated box 349261 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 349266 krueppel associated box 349274 Laminin G domain 349280 Calponin homology domain 349284 Calponin homology domain 349288 G-protein-coupled receptor proteolytic site domain 349289 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha 349293 ankyrin repeats 349294 ankyrin repeats 349318 FORKHEAD 349326 Serine/Threonine protein kinases, catalytic domain 349327 Laminin G domain 349334 FORKHEAD 349370 Homeodomain 349372 Homeodomain 349374 Alpha-lactalbumin / lysozyme C 349375 Pancreatic hormones / neuropeptide F / peptide YY family 349378 helix loop helix domain 349383 Histone H2B 349386 Homeodomain 349388 Actin 349398 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 349400 SAM / Pointed domain 349400 erythroblast transformation specific domain 349404 Tyrosine kinase, catalytic domain 349404 Serine/Threonine protein kinases, catalytic domain 349409 Epsin N-terminal homology (ENTH) domain 349415 krueppel associated box 349418 Domain with 2 conserved Trp (W) residues 349434 JAB/MPN domain 349436 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 349439 DEAD-like helicases superfamily 349459 Rab subfamily of small GTPases 349479 associated with SPRY domains 349479 Domain in SPla and the RYanodine Receptor. 349509 Homeodomain 349519 Dual specificity phosphatase, catalytic domain 349539 Bromodomain transcription factors and PHD domain containing proteins 349556 Immunoglobulin 349556 Immunoglobulin V-Type 349556 Immunoglobulin C-2 Type 349557 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 349603 krueppel associated box 349624 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 349625 Caspase, interleukin-1 beta converting enzyme (ICE) homologues 349642 DEAD-like helicases superfamily 349673 Ubiquitin homologues 349698 Rho (Ras homology) subfamily of Ras-like small GTPases 349712 Domain in SPla and the RYanodine Receptor. 349730 RNA recognition motif 349758 Ran-binding domain 349795 Domain in the RNA-binding Lupus La protein 349814 Homeodomain 349842 G protein alpha subunit 349861 Homeodomain 349881 Ribosomal protein L11/L12 349954 Ligand binding domain of hormone receptors 349954 c4 zinc finger in nuclear hormone receptors 349957 DnaJ molecular chaperone homology domain 349960 RNA recognition motif 349963 DEAD-like helicases superfamily 349963 helicase superfamily c-terminal domain 349996 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 350003 Protein tyrosine phosphatase, catalytic domain 350003 Protein tyrosine phosphatase, catalytic domain motif 350005 WD40 repeats 350006 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 350007 Immunoglobulin 350007 Immunoglobulin V-Type 350008 Immunoglobulin 350008 Immunoglobulin V-Type 350009 Immunoglobulin 350009 Immunoglobulin V-Type 350010 Immunoglobulin 350010 Immunoglobulin V-Type 350018 Ribosomal protein L11/L12 350042 Src homology 3 domains 350082 SERine Proteinase INhibitors 350127 RNA recognition motif 350156 leucine rich region 350178 domain in high mobilty group proteins HMG14 and HMG 17 350203 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) 350226 Immunoglobulin 350226 Immunoglobulin V-Type 350231 Immunoglobulin 350231 Immunoglobulin V-Type 350244 catalytic domain of ctd-like phosphatases 350245 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins 350264 Phospholipase A2 350346 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members 350350 Actin 350354 Serine/Threonine protein kinases, catalytic domain 350370 Immunoglobulin V-Type 350426 Src homology 2 domains 350431 bromo domain 350451 Protein kinase C conserved region 2 (CalB) 350455 DnaJ molecular chaperone homology domain 350515 helicase superfamily c-terminal domain 350588 Ubiquitin homologues 350604 Galectin 350609 Immunoglobulin 350609 Immunoglobulin C-2 Type 350611 Trypsin-like serine protease 350616 krueppel associated box 350634 krueppel associated box 350636 krueppel associated box 350638 krueppel associated box 350686 RNA recognition motif 350694 Histone H2B 350695 Histone H3 350696 Histone H2B 350699 Immunoglobulin 350704 RNA recognition motif 350744 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 350767 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain 350788 Immunoglobulin 350793 Pentraxin / C-reactive protein / pentaxin family 350837 krueppel associated box 350864 snRNP Sm proteins 350864 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) 350868 Tyrosine kinase, catalytic domain 350868 Serine/Threonine protein kinases, catalytic domain 350871 RNA recognition motif 350918 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein 350965 Homeodomain 351001 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain 351039 Actin 351040 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways 351076 GTPase-activator protein for Rho-like GTPases 351152 Ribosomal protein L11/L12 351195 WD40 repeats 351195 Lissencephaly type-1-like homology motif 351209 Ring finger 351348 krueppel associated box 351351 RNA recognition motif 351429 Histone H3 351465 Rab subfamily of small GTPases 351465 Ras subfamily of RAS small GTPases 351465 Rho (Ras homology) subfamily of Ras-like small GTPases 351465 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 351550 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 351596 Tyrosine kinase, catalytic domain 351596 Serine/Threonine protein kinases, catalytic domain 351597 Furin-like repeats 351600 RNA recognition motif 351672 Ring finger 351672 associated with SPRY domains 351672 Domain in SPla and the RYanodine Receptor. 351682 Trypsin-like serine protease 351814 Src homology 3 domains 351864 BAR domain 351864 Src homology 3 domains 351864 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 351890 Histone H3 351934 Histone H3 351942 domain present in cyclins, TFIIB and Retinoblastoma 352037 RNA recognition motif 352118 Histone H3 352145 RNA recognition motif 352161 Ras association (RalGDS/AF-6) domain 352162 Ras association (RalGDS/AF-6) domain 352193 Rho (Ras homology) subfamily of Ras-like small GTPases 352196 K homology RNA-binding domain 352384 Histone H4 352393 krueppel associated box 352400 DnaJ molecular chaperone homology domain 352436 RNA recognition motif 352455 krueppel associated box 352464 Defensin/corticostatin family 352472 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases 352507 Histone 2A 352559 Serine/Threonine protein kinases, catalytic domain 352587 ADAM Cysteine-Rich Domain 352587 Homologues of snake disintegrins 352625 Coagulation factor 5/8 C-terminal domain, discoidin domain 352631 Found in Skp1 protein family 352632 Found in Skp1 protein family 352638 Found in Skp1 protein family 352643 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 352645 krueppel associated box 352655 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 352656 Ring finger 352659 Immunoglobulin 352659 Immunoglobulin V-Type 352659 Immunoglobulin C-2 Type 352662 Ring finger 352662 Immunoglobulin 352662 Immunoglobulin V-Type 352664 Laminin G domain 352669 C2C2 Zinc finger 352670 Ring finger 352670 Immunoglobulin 352670 Immunoglobulin V-Type 352671 3'-5' exonuclease 352699 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 352700 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon 352733 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity 352837 Ubiquitin-conjugating enzyme E2, catalytic domain homologues 352864 ARF-like small GTPases 352897 RNA recognition motif 353118 Serine/Threonine protein kinases, catalytic domain 353118 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 353130 Trypsin-like serine protease 353149 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases 353188 ADAM Cysteine-Rich Domain 353188 Homologues of snake disintegrins 353211 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) 353233 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins 353251 Trypsin-like serine protease 353253 Immunoglobulin 353274 leucine rich region 353274 krueppel associated box 353283 Ras subfamily of RAS small GTPases 353287 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) 353287 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n 353302 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division 353305 Domain first found in the mice T locus (Brachyury) protein 353328 von Willebrand factor (vWF) type D domain 353328 C-terminal cystine knot-like domain (CTCK) 353355 krueppel associated box 353376 Toll - interleukin 1 - resistance 353500 Transforming growth factor-beta (TGF-beta) family 359710 BPI/LBP/CETP C-terminal domain 359728 Rab subfamily of small GTPases 359959 Ras subfamily of RAS small GTPases 360013 Myosin. Large ATPases. ATPase 360013 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides 360161 Serine/Threonine protein kinases, catalytic domain 360204 leucine rich region