LOCUS NZ_ACVX01000021 64755 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00023, whole genome shotgun sequence. ACCESSION NZ_ACVX01000021 NZ_ACVX00000000 VERSION NZ_ACVX01000021.1 GI:256004959 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 64755) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 64755) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000021. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..64755 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene 27..2435 /locus_tag="ClothDRAFT_1793" CDS 27..2435 /locus_tag="ClothDRAFT_1793" /inference="protein motif:PFAM:PF03415" /note="PFAM: peptidase C11 clostripain; KEGG: bgl:bglu_1p0890 peptidase C11, clostripain" /codon_start=1 /transl_table=11 /product="peptidase C11 clostripain" /protein_id="ZP_05429932.1" /db_xref="GI:256004960" /db_xref="InterPro:IPR005077" /translation="MNRDNRPTGRQKRIGSGTGNVSRRGSGLGSGPVGRPGGYSDRSK GTGTSGRSGPARSFGSYGSYGGYGGYSSGRRRRSSGCSKYLTILILILAIAYYIYSNF GGGSGNSTSTNNFLNGTSSVSGYVDKGEYPVDTTVSELARAKRTVLKGNGEDIATVMI YMCGTDLESKWGMATADLKEMLNAEISDKVNIIVETGGTLKWQNNTVDSSTNQRFKVT NDGLKLLEGNLGKKSMVEPETLSDFIKYCKTNFPADRYMLILWDHGGGSVSGYGYDQH YPSNTMRLDEIAVALKNGGCVFDLIGFDACLMATLETAIVLEPYADYMIASEEVEPGI GWYYTGWITALSRNTSIKTIDLGKKLIDDYVKEVRAKTPSSQATLSLVDLAELKGTIP QAFTKFAKSIDTLVTRNEYKTVSNARANTKEFAKSSKINQIDLINFAENLGTDEGKKL AEALRGCIKYNRTSKNITNANGLSIFFPYGNLSKVNSMLDTYEQIGIDKEYSKCIKSF ASVSAGGQIVSSGSNNMLEVLLGSFTEGSSNSGQSLTTAALEILLEEFLNSGNYGRIT GGESDSLDWLDVNLMKSSVDYYRKNRFDPSALKITEKNGQRVLSMSEEQWSLVQQMEM NVFIDDGEGFIDLGLDNVYEFNEDGDLVMEFDGTWLALNGNIVSYYMISDDRHGDTYS TKGRIPALLNGQLVDIIVVFDNENPYGKVLGAQIRYDTKAETETLAKGLIDIVAGDKI DFLCDYYTYEGEYIDTYFLGEQYTATGEWKIENLHLGYRDYQMTYRITDIYGNKYWTP SVTN" misc_feature 504..>1307 /locus_tag="ClothDRAFT_1793" /note="Clostripain family; Region: Peptidase_C11; cl04055" /db_xref="CDD:141798" gene 2469..3659 /locus_tag="ClothDRAFT_1794" CDS 2469..3659 /locus_tag="ClothDRAFT_1794" /inference="protein motif:PFAM:PF01139" /note="PFAM: protein of unknown function UPF0027; KEGG: glo:Glov_0158 protein of unknown function UPF0027" /codon_start=1 /transl_table=11 /product="protein of unknown function UPF0027" /protein_id="ZP_05429933.1" /db_xref="GI:256004961" /db_xref="InterPro:IPR001233" /translation="MIEIKGKYNTAKVFTNNVEPEAMAQILELCNQEFVKDSVIRIMP DTHAGAGCTIGTTMTIDDKIVPNLVGVDIGCGMETIKLKNKNIELSKLDKVIHEFIPS GFDIRKKEHPYVRNINLDELLCKKHVDINRAKLSIGTLGGGNHFIEVNKDSEGNLYLV VHSGSRHLGKQVAEYYQELGYKELVKNTEVIKEIIAKLKAEGREKEIEKEIKKIKPPN ISKQLAYVQGKSYEDYLADMKLVQKFAVLNRKAIVDEIVRRMNFKIEEQFTTIHNYID LDSMILRKGAISARKGERVLIPINMRDGSLICIGKGNKDWNYSAPHGAGRLMSRAKAK EVITLKEFKESMKGIYSTTVNKSTIDECPMAYKPMEEIIENIQDTVEIVDIIKPIYNF KAAE" misc_feature 2499..3650 /locus_tag="ClothDRAFT_1794" /note="Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032" /db_xref="CDD:175391" misc_feature 2595..3632 /locus_tag="ClothDRAFT_1794" /note="release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073" /db_xref="CDD:132117" gene 3734..6274 /locus_tag="ClothDRAFT_1795" CDS 3734..6274 /locus_tag="ClothDRAFT_1795" /inference="protein motif:PFAM:PF01841" /note="PFAM: transglutaminase domain protein; SMART: transglutaminase domain protein; KEGG: dal:Dalk_1546 transglutaminase domain protein" /codon_start=1 /transl_table=11 /product="transglutaminase domain protein" /protein_id="ZP_05429934.1" /db_xref="GI:256004962" /db_xref="InterPro:IPR002931" /translation="MNDRKNLINLAVFLLVALLSTLLIMAAISMLDLRGNGSPGGENN KRASQNDGSGKNRNKQDRNNNNKNKKGSGQREDDNGSNWKERAQRRRGERRSFDRGDY AYGQGPESMIPGDGWEYDIAPDQMPNLDISGNEGLPDMSFGMGGNTFVLKEGKNSHIP AFEVLGVPNYPFVRVMAMDNYRRSHWSMINEAPELMFLFGEKVDRKFSENTVKIKPVE PSKGYIPVLSGNFEMKYEFSLLEYKQSGVFYSTGVIENFYEMKYEDPPTEAELINAKT DDDYYYDIYVPEVVERIVDEVIENCETDYEAIKFVEKFLLENYTYDNTVLNNYGSGDA VVSFLTGKDRVGNHLDFVSAYAIILRAAGIPCRLALGYKLLPGVKYQVVYADQVYIYP EIKFEDYGWVPMDVFPYDVFYRPPKETITQITFADGTTKRGETVTVRGTVTDSSGNPI DNMTVLVYLKQYKSEPCISYAKAYVTNGNFEAVFDIKGDISAGKYHIIADVLENDVYR TSSSDPELKILADTFIDLEERSDIIGNKLNFAGRIVDFFTYEGIEGLEVHVSFEGMDL VETVVSEEDGKLYKEIEIEVPEDYPYYKNFFFAGRYLLFYGIEFKGTEIYTPYFTRRG VYMWKIYWINVTVAVVLLLGVVLLCVAIVLRKKGAFRRDGGKFPVLAAEGPGMIVAAD AGAESVERNHGKVYIEFPQIGEGLPDVWGIKENLAVVFHDDEGNRGEIGAVFHKKGEY RIKISGKNDEYGARNIRIVDYREEIIAIGKNFLKEMSAKISGITDFMTLREIHDIIKP NIASERHWVLEDAFMVFEKAVYSDEDIVRSDYEKFYVFARELGKNSSI" sig_peptide 3734..3814 /locus_tag="ClothDRAFT_1795" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.896 at residue 27" misc_feature 4631..4948 /locus_tag="ClothDRAFT_1795" /note="Transglutaminase-like superfamily; Region: Transglut_core; cl10469" /db_xref="CDD:176834" gene 6292..7443 /locus_tag="ClothDRAFT_1796" CDS 6292..7443 /locus_tag="ClothDRAFT_1796" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429935.1" /db_xref="GI:256004963" /translation="MRAGSRLKGDLPLNKLIIYSVVTLVYMALTVLIFFIPSGPAYNS RENYYFLIFSVEVFLVGLTARHFADYFFKGKWAKVLSDSCFVFGNGVSVFFFWILLPF DPQLKLAGCGIIPITVSIIIYKISKLYENRMLEGEIIKIISYLMAGFSAYFMFKTLWP ESRLGNLTLYSFIVLCVFELASFVELSGNKKAYGATGWLRSNHAGKFFVAFVTLFVVL DLRRMVMFESVLGVWIFIFLFLVVIFIIFTIKLSAAANNSPEERLGKHLQRINFDKIR DISDITSHINDFVYNGSKSGLIACLFIIMNKAGVPIFAAKRIIAPVVDHKDLEMPSFM TRKDYMVIEERNKQRRMKVVETVIKNLEVYGRGSYNGFGTGSSIVQKYN" gene 7400..8389 /locus_tag="ClothDRAFT_1797" CDS 7400..8389 /locus_tag="ClothDRAFT_1797" /inference="protein motif:PFAM:PF07726" /note="PFAM: ATPase associated with various cellular activities AAA_3; ATPase associated with various cellular activities AAA_5; KEGG: bra:BRADO4262 hypothetical protein" /codon_start=1 /transl_table=11 /product="ATPase associated with various cellular activities AAA_3" /protein_id="ZP_05429936.1" /db_xref="GI:256004964" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR011704" /translation="MVSEQVQALCKNIIDEVGKVFVADNDVILRKILCGFLAGGHILF EDNPGLGKTLLVKVFAKVTGCEWKRIQFTPDLMPSDILGTKIWKGNSSSFELEKGPIF TNFLLADEINRAMPKTQSALLEAMEERQVSIEGVTYQLKPPFIVMATQNPIEMEGTYP LPEAQMDRFIMKLSLGYLASAEKECEVLKRRIEWRKDDPTCDIKPVITMEQLLMLQSE VEKVYVDDNILMYITEIVRNTRVNPNIRLGASPRGALALLKLSRAHALVSGRNYVIPD DVKFMAVDALAHRVILHIERIMEGRVATAVIRSIVTKTEVPKSFTRENAGGLL" misc_feature 7400..8353 /locus_tag="ClothDRAFT_1797" /note="MoxR-like ATPases [General function prediction only]; Region: COG0714" /db_xref="CDD:31058" misc_feature 7520..7912 /locus_tag="ClothDRAFT_1797" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" misc_feature <7712..8269 /locus_tag="ClothDRAFT_1797" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" gene 8390..9730 /locus_tag="ClothDRAFT_1798" CDS 8390..9730 /locus_tag="ClothDRAFT_1798" /inference="protein motif:PFAM:PF01882" /note="PFAM: protein of unknown function DUF58; KEGG: gur:Gura_0188 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF58" /protein_id="ZP_05429937.1" /db_xref="GI:256004965" /db_xref="InterPro:IPR002881" /translation="MPKGVSKTGIVFLLLICVGFLLANNILILVSIIPFTLMAFGYYL KMPDGIRVDKTVSKNRVTVGELLEVSVRVLVESGFGSMEICDIVPPHFELVEGTNYCA VWKGFEPKEILLNYTVRCTASGTYTFRTTGWRARHAVGAFSINRKYETDLTVEVTPRL IELKKVRGMSTVCKVPMPEGALASMGMTTQEFKELRLYSPGDPFKAINWKVTSRNLVR GSIWPVVNEFEKEGKKSVWIFLDTSKIMSFGSNIKNVKEYSVEAVNSLSDYYIKHNCS VAFHTFGGSDVFINPGSGRQQHYRILRELMKIRNFTGVSRENSGERQKNSKEHKKLEE AVYSCRNYFNGLRPMFIIITRFCTKNSEEIFKGINLMSKYTSLRKGYVPSIMLINIMG YGLMAENENEMMAANLLEAMNKVLSEKIRKNCIWIDWDPNKESLTGALLKQVVG" sig_peptide 8390..8461 /locus_tag="ClothDRAFT_1798" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.944 at residue 24" misc_feature 8402..>9334 /locus_tag="ClothDRAFT_1798" /note="Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721" /db_xref="CDD:31907" misc_feature 8954..9226 /locus_tag="ClothDRAFT_1798" /note="Protein of unknown function DUF58; Region: DUF58; pfam01882" /db_xref="CDD:145184" gene 9734..10357 /locus_tag="ClothDRAFT_1799" CDS 9734..10357 /locus_tag="ClothDRAFT_1799" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429938.1" /db_xref="GI:256004966" /translation="MKVWTLSARILLSIAAYVLSYILFVCSSIYWDLVFLFKTQSRVF IIINIVAFIIIGLCYNKFEKAVGVICMLFAAPSVLVHSKMLKSEPAESVYTRYFPLHL TALLFLIITVLLMAAIRLQKLDRQYDEMISGGASEADVKLIILNNIKVYSVFLAVILF SGFVLVALAFAMSKIKATRLTVIITVTTGVVLVLGCVLYLYRKWTKK" gene 10542..12680 /locus_tag="ClothDRAFT_1800" CDS 10542..12680 /locus_tag="ClothDRAFT_1800" /inference="protein motif:PFAM:PF02518" /note="PFAM: ATP-binding region ATPase domain protein; periplasmic binding protein/LacI transcriptional regulator; SMART: ATP-binding region ATPase domain protein; KEGG: scl:sce5204 phosphoserine phosphatase" /codon_start=1 /transl_table=11 /product="histidine kinase" /protein_id="ZP_05429939.1" /db_xref="GI:256004967" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /translation="MKKRRTIGFLVNDIDVSYSNLVYLMTKKAAEKYDCNLIVYEGRS FNNPSMADSQHQISYSFVDNTRLDGIIITSATIACFISDEEFVEFCKRYEGIPLVSLG IVVPHATSILVDNKPGMKSQVEHLIKDHGFKKIVYISGPPTNTDSVERLEAYCEALRE NDIEVDDGLIFYGDFMAQSGYDIIKEIIKNGIEYDAVVCANDEMAFGAIKGIRDLKDA YNLDLTQKGVICGFDDSITSRLVKPSLTTVRQPIEEMCFYAVEAILKKIEGEKVEDVV KLPSVLVKRESCGCKNAAEVDFVSDSSLRLVPGQRIHENLQTYSLDELFDCITRTLKL CSIRSCFIFKYCGGTLLYEVDSIFRDDFRLPEDSELIYAYYNDERITIEDSIKYIKTR CIIPDRFFNEDRRFTYLVNPLFFYDEHFGYVCFEVANDDVLNFEPIRGQISNTLNGAL MLMERAKMEESLRETERLASLGQLIGGISHNLMTPIMSISGACFGLEDLVHEYMASIE DPSVTVQDHKEIARDMQEWINKLKEYNSYMSNVIATVKSQAVQLNSDAINEFTIEELV DRVKFIKNNNPQIRKAVLNCKIDIDGKTAIRGDISNLAQIIENLLINAVQSYEGMDNA SNIVDLHILKEENMVKCIVRDYGKGIPNEIRDRLFRRMVTTKGKNGTGLSLLLSYSTI KGKFGGELWVESKENEGSAFYVTIPLTDRE" misc_feature 10557..11399 /locus_tag="ClothDRAFT_1800" /note="family; Region: Peripla_BP_1; pfam00532" /db_xref="CDD:144207" misc_feature 10557..11390 /locus_tag="ClothDRAFT_1800" /note="Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267" /db_xref="CDD:107262" misc_feature order(10557..10559,10596..10604,10611..10616,10620..10625, 10644..10658,10662..10664,10716..10718,10722..10724, 10731..10739,11073..11075,11157..11159,11169..11171, 11178..11183) /locus_tag="ClothDRAFT_1800" /note="dimerization interface; other site" /db_xref="CDD:107262" misc_feature order(10593..10598,10605..10607,10758..10760,10845..10847, 10878..10880,10989..10991,11064..11066,11238..11240, 11289..11291) /locus_tag="ClothDRAFT_1800" /note="ligand binding site; other site" /db_xref="CDD:107262" misc_feature <11892..12677 /locus_tag="ClothDRAFT_1800" /note="Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642" /db_xref="CDD:30987" misc_feature 12348..12659 /locus_tag="ClothDRAFT_1800" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(12366..12368,12378..12380,12387..12389,12468..12470, 12474..12476,12480..12482,12486..12491,12555..12566, 12615..12617,12621..12623,12636..12641,12645..12647) /locus_tag="ClothDRAFT_1800" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature 12378..12380 /locus_tag="ClothDRAFT_1800" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature order(12480..12482,12486..12488,12555..12557,12561..12563) /locus_tag="ClothDRAFT_1800" /note="G-X-G motif; other site" /db_xref="CDD:28956" gene 12803..13855 /locus_tag="ClothDRAFT_1801" CDS 12803..13855 /locus_tag="ClothDRAFT_1801" /inference="protein motif:TFAM:TIGR01420" /note="KEGG: geo:Geob_0439 twitching motility protein; TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E; SMART: AAA ATPase" /codon_start=1 /transl_table=11 /product="twitching motility protein" /protein_id="ZP_05429940.1" /db_xref="GI:256004968" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006321" /translation="MELKEILKMGVDNKASDIHLTVGRAPSFRINGKMKTFTDNILSP EDTMSYAKECLDKEKLEHLMAVGEVDFSMTVPGISRFRVNVFFQRGSVAIVFRILAST IPTLDSLNFPEVIKDICKIKEGLILVTGPTGSGKSTTMASIINEINSTREGHILTLED PIEYIFKHDKCVVNQREISQDSKSYASALKAALREDPDVIFIGEMRDNESISIAVTAA ETGHLVLSTLHTLGAAKTIDRLIDVFPPHQQQQIRVQVSSALKAVISQRLIPDIDNKG RVAALEIMIVTPAISNLIREGRVAGITSMIQTGAAQGMKLLDKSIAELYQQGRISKES AYEYCADRELLKRFIG" misc_feature 12803..13852 /locus_tag="ClothDRAFT_1801" /note="Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805" /db_xref="CDD:32636" misc_feature 13172..13765 /locus_tag="ClothDRAFT_1801" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" misc_feature order(13190..13195,13205..13213) /locus_tag="ClothDRAFT_1801" /note="Walker A motif; other site" /db_xref="CDD:29986" misc_feature order(13193..13195,13205..13213,13271..13273,13277..13282, 13409..13414) /locus_tag="ClothDRAFT_1801" /note="ATP binding site; other site" /db_xref="CDD:29986" misc_feature 13397..13411 /locus_tag="ClothDRAFT_1801" /note="Walker B motif; other site" /db_xref="CDD:29986" gene 13985..15394 /locus_tag="ClothDRAFT_1802" CDS 13985..15394 /locus_tag="ClothDRAFT_1802" /inference="protein motif:PFAM:PF00404" /note="PFAM: cellulosome protein dockerin type I; regulator of chromosome condensation RCC1; KEGG: mxa:MXAN_0889 RCC1 repeat-containing protein" /codon_start=1 /transl_table=11 /product="cellulosome protein dockerin type I" /protein_id="ZP_05429941.1" /db_xref="GI:256004969" /db_xref="InterPro:IPR000408" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MRKYGLKKIVWMLGILCFLVVSLNTSIFAADGKNVVLGDVNGDS KINAIDVLLMKKYILKVINDLPSDGVKAADVNADGQINSIDFTWLKKYMLKAVEKFPG EASNNPDAVIQFESGFAHSVLLKKDGTVWVLGNNGKGQLGLPEVSAVNEPVMINGLSG IKSVAAGREHTLALQEDGTLWAWGNNYSLQLIEYMERDPDTKERFTSIPIKVETHSDI KYVAAKFSRTLIVKNDGTVWLYSLPPINTSSDAEYMPWEIKGFGDIKMADIGTGHIVA LREDGTVWTWGENVWGQLGNGWQQHHNIHTYIYFEPNQAKNLSDIVSIAAGDAHSVAL KSDGTVWTWGSNFNGELGNGTTTYILEPKKVEGLEDIVAIDAGIGHTVALKADGTVWV WGKNSYGQLGNGTTMRSTVPIQVEGLEGIVAIQAGMECTIAYKNDGTVWAWGKNDFGQ LGDGTFENILRPVKVFERK" sig_peptide 13985..14074 /locus_tag="ClothDRAFT_1802" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 at residue 30" misc_feature 14099..14161 /locus_tag="ClothDRAFT_1802" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 14204..14266 /locus_tag="ClothDRAFT_1802" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 14363..14506 /locus_tag="ClothDRAFT_1802" /note="Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415" /db_xref="CDD:144127" misc_feature 14822..14986 /locus_tag="ClothDRAFT_1802" /note="Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415" /db_xref="CDD:144127" misc_feature 14993..15136 /locus_tag="ClothDRAFT_1802" /note="Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415" /db_xref="CDD:144127" misc_feature 15143..15283 /locus_tag="ClothDRAFT_1802" /note="Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415" /db_xref="CDD:144127" misc_feature 15293..>15379 /locus_tag="ClothDRAFT_1802" /note="Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415" /db_xref="CDD:144127" gene 15418..16002 /locus_tag="ClothDRAFT_1803" CDS 15418..16002 /locus_tag="ClothDRAFT_1803" /inference="protein motif:PFAM:PF01694" /note="PFAM: Rhomboid family protein; KEGG: rhbdl2; rhomboid, veinlet-like 2 (Drosophila) ; K02857 rhomboid-related protein 1/2/3" /codon_start=1 /transl_table=11 /product="Rhomboid family protein" /protein_id="ZP_05429942.1" /db_xref="GI:256004970" /db_xref="InterPro:IPR002610" /translation="MSLQNRFKSLHYNSPVILTMTLLSLGALILQNITRGYTTSLLFS VYRSSPFSIFFYFRLFGHVLGHANWEHYMNNFLLILLLGPMLEEKYGSKRIAFMIAVT AVVTGVINILLFPRTALLGASGVVFMFILLSSFVNFKKGRIPITFILVVIIYLGGEVM NGIFVKDNISQLAHLVGGICGSVFGFKWAERSSW" misc_feature 15583..15993 /locus_tag="ClothDRAFT_1803" /note="Rhomboid family; Region: Rhomboid; cl11446" /db_xref="CDD:187043" gene 16225..18348 /locus_tag="ClothDRAFT_1804" CDS 16225..18348 /locus_tag="ClothDRAFT_1804" /inference="protein motif:PFAM:PF00089" /note="PFAM: peptidase S1 and S6 chymotrypsin/Hap; KEGG: mxa:MXAN_4433 S1C family peptidase" /codon_start=1 /transl_table=11 /product="peptidase S1 and S6 chymotrypsin/Hap" /protein_id="ZP_05429943.1" /db_xref="GI:256004971" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR001940" /translation="MKITGVIVRIHKDRAIIRTDDNRLLAVKRHNDMMVGQIVSFDAN EVHKVESKKYKYAASGKRIEKVQKTPKIKNFSRINNIKEFSRVDDIKNFSRVAATKET SQDSPQESKVENFSRVVDFSRVMNFSRVSNSKKNEIKNFSRISNIKNFSRIASIAAAF VLIFLFGRNVMLNNSSGSEYAYVSVDVNPSVEFTINSKHKVIVTSAINQDASEVLDGL ELKEKDLKSALVMVLEKAESLGYISDDKNYVLVSMALNDKNKKTRDKREEKIDELKET IEQGIEALDNDTIVHRTVTVDLEERNKALENELSMGRYYLYLEAKEKGMDITIDEVKS SKISDLIEKIEDNTELAPTPTPVPPETPEPTPTPTASEATPSNSPVESKSPEAVPELG SREIEILGESVVLVTAYDENRKVVSQGSGFAVGTGLFATNYHLVKDGVVVKITAGDGK VYDVDGIVKYDKAKDLALLKTTVETGVNPLKLGTKKSLTKGSRIVAIGKANGAKNTVT KGSIKSLKVDGLTDAIELSASISKESTGGPVFDMKGNVVGITAYGISKQNVNAVIPAD YVADWVKELSKHSFGNIRIVRKTLVFDSDFEFNFVVYKIIRALENEDAATYFGCMTDE LYKDETRKNLEVLFTTYDLAYNIESINVVSKSEEQAKVSYVYTINKEAGPNFKNYRII GECSLIKVDGTWKINDSEEKKEYIQ" misc_feature 17452..>17958 /locus_tag="ClothDRAFT_1804" /note="Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265" /db_xref="CDD:30614" gene 18512..19165 /locus_tag="ClothDRAFT_1805" CDS 18512..19165 /locus_tag="ClothDRAFT_1805" /EC_number="3.1.3.18" /inference="protein motif:TFAM:TIGR01549" /note="KEGG: bur:Bcep18194_B0962 haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase" /codon_start=1 /transl_table=11 /product="HAD-superfamily hydrolase, subfamily IA, variant 1" /protein_id="ZP_05429944.1" /db_xref="GI:256004972" /db_xref="InterPro:IPR005833" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006439" /translation="MIKYKAVFFDFDYTLADSSKAVIECINYALQKMGYPESSPESIC RTIGLTLAEAFKILSGDTSDSNADLFRQYFKERADLVMCDRTVMYSTVECVLKKLKKA DVKTGIVSTKYRYRIEDILKRDKLLQYFDVIVGGEDVAAHKPDPEGLLKAISMVGCQK EEVLFVGDSTVDARTAKNAGVDFVAVLTGTTGANEFSEYNPGAVIEDLSGLLDMFML" misc_feature 18518..19138 /locus_tag="ClothDRAFT_1805" /note="Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637" /db_xref="CDD:30982" misc_feature <18794..19069 /locus_tag="ClothDRAFT_1805" /note="Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427" /db_xref="CDD:119389" misc_feature 18839..18841 /locus_tag="ClothDRAFT_1805" /note="motif II; other site" /db_xref="CDD:119389" gene 19224..20519 /locus_tag="ClothDRAFT_1806" CDS 19224..20519 /locus_tag="ClothDRAFT_1806" /inference="protein motif:TFAM:TIGR00407" /note="TIGRFAM: gamma-glutamyl phosphate reductase; PFAM: Aldehyde Dehydrogenase; KEGG: glutamate-5-semialdehyde dehydrogenase ; K00147 glutamate-5-semialdehyde dehydrogenase" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="ZP_05429945.1" /db_xref="GI:256004973" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR015590" /translation="MSISEMAFQVKEASIRLAAAGTELKNKALENIARLLMERKDEII KANNEDLQRSREEKLAEPLLKRLKFDEAKIVDVIDGINSLIKLEDPVGKTLLSTELDE GLELYRVTCPIGVVGIIFESRPDALVQISTLCLKSGNGVLLKGGSEARETNKILAQII TEATEEVGIPPNWIKLLETRADVNEMLKMDKYIDLIIPRGSNEFVRYIMDNSRIPVMG HADGICHCYIDEDADIDMAIRIVVDSKTQYVAVCNATETLLVHKNIAPKVLPELKRAL DSKNVELVGCSETQKIIPVAPATEEDWRTEYLDYKLSVKVVGDLEEAIEHINTYGSGH TDSIITNSKEKAAAFMSLVDSGNVFWNCSTRFSDGFRYGFGAEVGISTSKIHARGPVG LDGLLIYKYKLIGNGHIVEDYAKRTKSFKHNKMNKQFPL" misc_feature 19236..20441 /locus_tag="ClothDRAFT_1806" /note="Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079" /db_xref="CDD:143398" misc_feature 19254..20423 /locus_tag="ClothDRAFT_1806" /note="gamma-glutamyl phosphate reductase; Region: proA; TIGR00407" /db_xref="CDD:161862" misc_feature 19977..19979 /locus_tag="ClothDRAFT_1806" /note="putative catalytic cysteine; other site" /db_xref="CDD:143398" gene 20785..21156 /locus_tag="ClothDRAFT_1807" CDS 20785..21156 /locus_tag="ClothDRAFT_1807" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429946.1" /db_xref="GI:256004974" /translation="MNYQEIEKLKAVLTKMMKKGCMLMIPAYGAEGRIVSIGFRPYWT NPGDSKIEKLEINFVDNRGRVVPLCIYSIIGYEIVSFEGRSLEDAKNISLDIHSYANV KGRKAEKYDTLHLEIGEISDE" gene 21257..21682 /locus_tag="ClothDRAFT_1808" CDS 21257..21682 /locus_tag="ClothDRAFT_1808" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: GK22755 gene product from transcript GK22755-RA" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429947.1" /db_xref="GI:256004975" /db_xref="InterPro:IPR000890" /translation="MAEEIRGYGDASLPALLSKHIGETVTIFTKSGGQSGAGFTGVIL SVNDCFVRLITRIGPPPACSLGNACTNFNVDHGYDYKNPFGSYDCGHGYGKGHGYIQP ASELGTVSAGGWNGYPVYTVGSVTDIPISAIVSFVHNAV" gene 21933..23054 /locus_tag="ClothDRAFT_1809" CDS 21933..23054 /locus_tag="ClothDRAFT_1809" /EC_number="2.6.1.44" /inference="protein motif:PRIAM:2.6.1.44" /note="PFAM: aminotransferase class V; KEGG: Serine-pyruvate aminotransferase" /codon_start=1 /transl_table=11 /product="Alanine--glyoxylate transaminase" /protein_id="ZP_05429948.1" /db_xref="GI:256004976" /db_xref="InterPro:IPR000192" /translation="MNKPLVMTPGPTYVHEDVRRAMQQEVGNPDVEESFFEFYRETCE RLKELLKTKNDVIILSGEGILGLEAACASVIEPGDRVLCIDNGIFGNGFGDFVKMYGG EATYLKFDYRRAVDVNVVENFLKNDHNFKAATLVHCETPSGITNPIADICKMLKRYGI LSIVDAVSSIGGEPLEADEWEIDVVLGGSQKCISAPPGLTFMSISRDAWNAILKRKTP IIGYYCNLAVWKSWYEDRWFPYTQPVSDIYALRAAVDRLLQDDLRIERHKNIADRVRA ALADRGLELYPENGFSNTVTAFYVPDGATFTDIYNIMLSEHNILIAGSFGFLKDKVIR IGHMGENCYEDKILKTFAALDKTFEKLNIDLRNKLPGSR" misc_feature 21945..22997 /locus_tag="ClothDRAFT_1809" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321" /db_xref="CDD:185903" misc_feature order(22119..22124,22131..22133,22338..22340,22425..22427, 22434..22436,22494..22496,22503..22505) /locus_tag="ClothDRAFT_1809" /note="pyridoxal 5'-phosphate binding pocket; other site" /db_xref="CDD:99742" misc_feature 22503..22505 /locus_tag="ClothDRAFT_1809" /note="catalytic residue; other site" /db_xref="CDD:99742" gene 23280..24767 /locus_tag="ClothDRAFT_1810" CDS 23280..24767 /locus_tag="ClothDRAFT_1810" /inference="protein motif:PFAM:PF00015" /note="PFAM: chemotaxis sensory transducer; SMART: chemotaxis sensory transducer; KEGG: glo:Glov_3335 methyl-accepting chemotaxis sensory transducer" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis sensory transducer" /protein_id="ZP_05429949.1" /db_xref="GI:256004977" /db_xref="InterPro:IPR004089" /translation="MKEITLESHARRVNKVLLFIFWAYFFVCIVLGMTITAPTSLISI ESIPLIIFFAGMITSTIYFVKRKYNDITGLILCLSVMVSLVATYFNLNSVVEETMILV LVIPACAMALYLNKRNFAIYAVCFNLLCVIFEAVYKTMGMQKFISDLVKIDFILLFLY FSAKWGSEIIHQMIEKEKNSNNILNKLEDTMGFLRKNTEILNRDIMNCNMTLKMIKES GDSVALAVEEVAKGISEEAESVSNINVMMSEADKLVADTAAISREMAEVSVSTVQIVN EGVKNINEMNKQMDIINTAVNESYSTVLKLQESMDRVNEFLQGITEIAEQTNMLALNA SIEAARAGESGKGFAVVADEVRRLAEQSTQTVGLIHQVITNIKDEADAILDKVYSGTE ATKAGEAIVKKVSESYDRMNQSFKDIDNYIDSELKMIENTTLLFSQIRKEMESIAGIS QEHAAASEEMAASMQDQKDKIESIFNSMKEIQKSSEELEMIVKDK" misc_feature 23952..24725 /locus_tag="ClothDRAFT_1810" /note="Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283" /db_xref="CDD:128579" misc_feature 24126..24635 /locus_tag="ClothDRAFT_1810" /note="Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144" /db_xref="CDD:153541" gene complement(24880..26916) /locus_tag="ClothDRAFT_1811" CDS complement(24880..26916) /locus_tag="ClothDRAFT_1811" /inference="protein motif:PFAM:PF00942" /note="PFAM: type 3a cellulose-binding domain protein; KEGG: similar to hedgehog protein" /codon_start=1 /transl_table=11 /product="type 3a cellulose-binding domain protein" /protein_id="ZP_05429950.1" /db_xref="GI:256004978" /db_xref="InterPro:IPR001956" /translation="MNGAQNNMSHYTGIILKLESDRAIVLTDGLDFMELKLKPGMQRG QHVIFDESDLYSAGLITRYKSIIMPFSAFAAAAAVFLVILFSLRFVSISQEYAYIDVD INPSIGLVIDKKEKVIDAKPLNNDAKPILDEAAPKDMPLYDALSKILDISKKNGYINS ADNIVLFSASINSGRNNVSESDKGIQEIISTLKDVAKDAGVKFEIIPSTEEDRQKALD QNLSMGRYAIYVKAVEEGVNLNLEDARNLSVSEILGKVNIGKFAISDTPEDSGIMPAI SVPAEPVPSVTPAYTAVPEKTEAQPVDIPKSSPTPASFTAHVPTPPKTPSIPHTSGPA IVHTPAADKTTPTFTGSSTPVPTNVVAIASTPVPVSTPKPVSTPAYSSTPTPESTPVP VSTPKPASTPTPASTPKPVSTPTHVSTPKPISTPTSTPRPASTPKPTSTPTPESTPKP TSTPAPVSTPTSTPIPTYTSTPASTPIPAYTSTPTSIPTLTPATSPAPTSSPTPIPSP APTETDLLTKIELQAYNHIRTSETKELQPRIKLINTGNTPITLSEVKIRYYYTKDQVI NEIYTCDWSNITSSKITGTVVQMSNPKPNADSYVEIGFTNSAGVLNPGEYVEIISRIG NSYALSLATPPYSEWNYMYDQNSDYSFNNSSSDFVVWDKITVYISGTLYWGIEP" misc_feature complement(<25849..>26085) /locus_tag="ClothDRAFT_1811" /note="envelope glycoprotein I; Provisional; Region: PHA03291" /db_xref="CDD:165548" misc_feature complement(25108..25356) /locus_tag="ClothDRAFT_1811" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" gene complement(26897..27694) /locus_tag="ClothDRAFT_1812" CDS complement(26897..27694) /locus_tag="ClothDRAFT_1812" /inference="protein motif:TFAM:TIGR02895" /note="TIGRFAM: RNA polymerase sigma-I factor" /codon_start=1 /transl_table=11 /product="RNA polymerase, sigma 28 subunit, SigI" /protein_id="ZP_05429951.1" /db_xref="GI:256004979" /db_xref="InterPro:IPR014244" /translation="MIDLFSPKGKKDTVSTTNKDKSFEDGIVNIINKIKAGDKLLREE FINSYTPYIIRTVSNLTGKYVDVENSDEFSVGLAAFNEAIDSFDEGKNMFFFKFSTLV IKRRLTDYARHNKKHCHVYPFTYFEDKNNSYFEQIHLKSEIDLQNTYEISREIELYEQ KLRDFGISLEHLAKCAPKHKDSKSLCIKIAKVIADNKELFSKLERTRNIPKTELLKLL KINKKTIERNRTFIIAAALIFGNDFNLLKDFLDISEPGGDNIERSTK" misc_feature complement(26924..27628) /locus_tag="ClothDRAFT_1812" /note="putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311" /db_xref="CDD:181376" misc_feature complement(27347..27562) /locus_tag="ClothDRAFT_1812" /note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542" /db_xref="CDD:146937" gene 28267..29667 /locus_tag="ClothDRAFT_1813" CDS 28267..29667 /locus_tag="ClothDRAFT_1813" /inference="protein motif:PFAM:PF01270" /note="PFAM: glycoside hydrolase family 8; cellulosome protein dockerin type I; KEGG: hch:HCH_06791 endoglucanase Y" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 8" /protein_id="ZP_05429952.1" /db_xref="GI:256004980" /db_xref="InterPro:IPR002037" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MLILAVLGVYMLAMPANTVSAAGVPFNTKYPYGPTSIADNQSEV TAMLKAEWEDWKSKRITSNGAGGYKRVQRDASTNYDTVSEGMGYGLLLAVCFNEQALF DDLYRYVKSHFNGNGLMHWHIDANNNVTSHDGGDGAATDADEDIALALIFADKLWGSS GAINYGQEARTLINNLYNHCVEHGSYVLKPGDRWGGSSVTNPSYFAPAWYKVYAQYTG DTRWNQVADKCYQIVEEVKKYNNGTGLVPDWCTASGTPASGQSYDYKYDATRYGWRTA VDYSWFGDQRAKANCDMLTKFFARDGAKGIVDGYTIQGSKISNNHNASFIGPVAAASM TGYDLNFAKELYRETVAVKDSEYYGYYGNSLRLLTLLYITGNFPNPLSDLSGQPTPPS NPTPSLPPQVVYGDVNGDGNVNSTDLTMLKRYLLKSVTNINREAADVNRDGAINSSDM TILKRYLIKSIPHLPY" sig_peptide 28267..28332 /locus_tag="ClothDRAFT_1813" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.955 at residue 22" misc_feature 28399..29391 /locus_tag="ClothDRAFT_1813" /note="Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351" /db_xref="CDD:186423" misc_feature 29578..29637 /locus_tag="ClothDRAFT_1813" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene 29814..31268 /locus_tag="ClothDRAFT_1814" CDS 29814..31268 /locus_tag="ClothDRAFT_1814" /inference="protein motif:PFAM:PF00704" /note="PFAM: glycoside hydrolase family 18; cellulosome protein dockerin type I; SMART: chitinase II; KEGG: cja:CJA_0988 endo-chitinase, putative, chi18B" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 18" /protein_id="ZP_05429953.1" /db_xref="GI:256004981" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR001579" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /db_xref="InterPro:IPR011583" /translation="MKKIPLLMLLSAIIFLSLHPTLSYAQDDSLPTKRIVGYFAEWNI YLENNYYEVSDIPWDMVTHINYAFAKIENGRIAIIDKWAAIQKPFGDDTWDTPIRGHF GQLIKYKEQYPHVKTLISVGGWTESKYFSDVALTEESRNTFADSCVEFIRTYRFDGVD IDWEYPVSGGMPENIRRPEDKQNFTLLLKCLREKLDAAGAEDGKHYLLTIAAPAGSFN IKNTEPEIYHQYLDFINIMTYDYSGSWENVANHLAPLYMNPNDPSYPERKEKFNVDWT VKEYLRLGVPAEKINVGVPYYAAGWQEVNGGINGLFGTSSKPLSSTQFHYINSLLKSP DLGFTRYWDEYAMVPYLWNPESATFYSYEDEISLKNKCDYVIENNLGGIMIWELSGDY PAEGGTTLTSVIYDSFTSFKDEIYGDLNGDGKVNSSDLAILKRYMLRAISDFPIPEGR KLADLNRDGNVNSTDYSILKRYILKAIDNIPVDD" sig_peptide 29814..29891 /locus_tag="ClothDRAFT_1814" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 at residue 26" misc_feature 29913..30986 /locus_tag="ClothDRAFT_1814" /note="Glycosyl hydrolase family 18; Region: Glyco_18; smart00636" /db_xref="CDD:128884" misc_feature 29916..30986 /locus_tag="ClothDRAFT_1814" /note="The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548" /db_xref="CDD:119365" misc_feature order(29925..29927,30015..30017,30291..30293,30297..30299, 30303..30305,30522..30524,30528..30533,30702..30704, 30969..30971) /locus_tag="ClothDRAFT_1814" /note="active site" /db_xref="CDD:119365" misc_feature 31065..31127 /locus_tag="ClothDRAFT_1814" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 31173..31235 /locus_tag="ClothDRAFT_1814" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene 31485..32411 /locus_tag="ClothDRAFT_1815" CDS 31485..32411 /locus_tag="ClothDRAFT_1815" /inference="protein motif:PFAM:PF00942" /note="PFAM: type 3a cellulose-binding domain protein; KEGG: similar to hedgehog protein" /codon_start=1 /transl_table=11 /product="type 3a cellulose-binding domain protein" /protein_id="ZP_05429954.1" /db_xref="GI:256004982" /db_xref="InterPro:IPR001956" /translation="MKWYYKSKVKRQVIKTLITLPVVLVLTSLVVYTFLTNNRSGSRD ADGTFPDSVKSPSIAINTPSPGTDATASAGLVPDNTFLTEHTNAPTPTDDITPTPTPT LEPTPEPTATPTSTPTFTPTSKPTPKPTATPTRKPTPTPTHTPTPKPAQKTPEKKGPI ITVQYKNGDSTSSVTAIYPIFKITNNGDTSVKLSDIIIRYYYTKEGNENETFWCNEFT RDGSQVYGTFVKMSKPKENADHYLEIGFYDKAGSLKPGESVELKVGFAKNGWTKYNQF NDYSYNRVNNRFINWDHITVYLSGKLVYGKEP" sig_peptide 31485..31586 /locus_tag="ClothDRAFT_1815" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.947) with cleavage site probability 0.884 at residue 34" misc_feature 31971..32219 /locus_tag="ClothDRAFT_1815" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" gene complement(32541..33695) /locus_tag="ClothDRAFT_1816" CDS complement(32541..33695) /locus_tag="ClothDRAFT_1816" /EC_number="3.4.16.4" /inference="protein motif:PRIAM:3.4.16.4" /note="PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: abo:ABO_1959 D-alanyl-D-alanine-carboxypeptidase" /codon_start=1 /transl_table=11 /product="Serine-type D-Ala-D-Ala carboxypeptidase" /protein_id="ZP_05429955.1" /db_xref="GI:256004983" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012907" /translation="MYNLKGFRSVSVLAVITFFVMMFQVKAFAQFESSAQSAILIEAS TGQVLYEKNADVPMPPASITKIMTLLLGFEALEKGLVKWDDEVIISEKAWRMEGSKMF LLVGDKAKFGEIMTGISVVSANDGCVALAEHLYGSEEAFVQVMNTRAKELGLTNTNFA NSNGLPAEGHVMSARDISTLARYLIQNYPKILELESTTEYTYNNIRQFNRNPLLGVFP GADGLKTGWTEEAGYCIVGTAQQNGQRMIGVVLKTSSEKERSKAIQELLNYGFKNFKQ VTVKNAGEIVDSIEVKNGKKLSVSLKLDSDISTVIPVGRENDLQIVTSKKAEFLNAPV SLDIPAGTVEVQLDGKTIATSTMSTAEEAERLGFFAMILRNIANFFKSLF" sig_peptide complement(33606..33695) /locus_tag="ClothDRAFT_1816" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.566 at residue 30" misc_feature complement(32943..33581) /locus_tag="ClothDRAFT_1816" /note="Beta-lactamase; Region: Beta-lactamase; cl01009" /db_xref="CDD:186300" misc_feature complement(32943..33581) /locus_tag="ClothDRAFT_1816" /note="D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768" /db_xref="CDD:144388" misc_feature complement(32601..32876) /locus_tag="ClothDRAFT_1816" /note="Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943" /db_xref="CDD:149169" gene complement(33837..35441) /locus_tag="ClothDRAFT_1817" CDS complement(33837..35441) /locus_tag="ClothDRAFT_1817" /inference="protein motif:TFAM:TIGR00254" /note="KEGG: gme:Gmet_0018 metal dependent phosphohydrolase; TIGRFAM: diguanylate cyclase; metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; GGDEF domain containing protein; Metal-dependent hydrolase HDOD; SMART: GGDEF domain containing protein; metal-dependent phosphohydrolase HD region" /codon_start=1 /transl_table=11 /product="diguanylate cyclase and metal dependent phosphohydrolase" /protein_id="ZP_05429956.1" /db_xref="GI:256004984" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR013976" /translation="MQYDEKRSKTIAFFNKHFFNVSFVFLVGILVIYIIYETGHFFPT FLYMSAFAAMMITAKFFIRHKALKHLLAVLSYVLFIFVVDSHSLPYPYYTVVNKWSVL TICYVLLLENILFPLIAGLYPALRIFMLMPEAKAGLYPIGKVIGTANGQICFTITLVL IYQLFGKVIIERNKYKKMSITDSLTGVATFAHTIETAKKMIQNGNISILITDMDRFKQ INDTFGHVAGNKVLIKVSEFLKEETEGLERIIGRLGGDEFIIVVKNDGKNERVKNLGE HLSKAIREKKFVIDEELDPINLSFSVGQANSSPSDTENDIEKLLYKADINMYYNKCKN HRLDIFTNNKKPLLPKEGFELLNVLAEKDMYTYVHSRYTAQYAAALAKEAGLPDEQVE RIYAAGWLHDIGKILISSDIIRKSTTLTPEEYELIKGHVNYGLNIINNLSLPVEIINC IAYHHENWDGTGYPHGLAGESIPFEARILQLADSYSAMIIRRVYRKTLSPEDALNEII SGCGKQFDPNLVKIFVKLIQSKFKAA" misc_feature complement(34449..34901) /locus_tag="ClothDRAFT_1817" /note="Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949" /db_xref="CDD:143635" misc_feature complement(order(34674..34676,34806..34808)) /locus_tag="ClothDRAFT_1817" /note="metal-binding site" /db_xref="CDD:143635" misc_feature complement(order(34671..34682,34686..34688,34755..34757, 34767..34769,34779..34784,34791..34793)) /locus_tag="ClothDRAFT_1817" /note="active site" /db_xref="CDD:143635" misc_feature complement(order(34611..34613,34701..34703)) /locus_tag="ClothDRAFT_1817" /note="I-site; other site" /db_xref="CDD:143635" misc_feature complement(33918..34349) /locus_tag="ClothDRAFT_1817" /note="Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077" /db_xref="CDD:28958" misc_feature complement(order(33993..33995,34236..34241,34335..34337)) /locus_tag="ClothDRAFT_1817" /note="Zn2+ binding site; other site" /db_xref="CDD:28958" misc_feature complement(34236..34238) /locus_tag="ClothDRAFT_1817" /note="Mg2+ binding site; other site" /db_xref="CDD:28958" gene complement(35683..37374) /locus_tag="ClothDRAFT_1818" CDS complement(35683..37374) /locus_tag="ClothDRAFT_1818" /inference="protein motif:PFAM:PF00759" /note="PFAM: glycoside hydrolase family 9; cellulosome protein dockerin type I; KEGG: hch:HCH_02464 cellulase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 9" /protein_id="ZP_05429957.1" /db_xref="GI:256004985" /db_xref="InterPro:IPR001701" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MRKIAVLLITLTFLVTTLFSMSFSSAAASHDYATALKYSILFYD ANKCGPDAAVDNVFSWRGPCHTTDGSEIGLDLTGGYHDAGDHVKFGLPQAYAAAVLGW SLYEYKGVFDATGNTSKMLSTLKYFTDYLLKCHPDSNTFYYQVGDGQADHTYWGAPEV QPGPRPVPYVANASNAASDVCGLTSAALTIMYLNYKDIDQNYANKCLKAAKELYTMAK TNLGYYAENAFYISHSYWDDLSFAATWLYVVEKDPTYLKEIDSYLSNKTLWGESPFNN KWTMCWDDMYMAVFCKLAEITGEQKYIDAMNYNLDYWMNSLNTTPGGLKYLDSWGVLR YAAAEAFIAMRYYELTKNEALKSFAKSQIDYILGSNPINMSYVIGYGSNYPKCPHHRA ANGYTYANGDNAKPAKNLLLGALVGGPNMSDNFIDDVNQFQFTEVAIDYNAAFVGALA AIEKYYGNIVIPTPPATTPPSPTATPSLIWCDVGDLNVDGSINSVDITYMKRYLLRSI SVLPYQENERIRIPAADTNGDGAINSSDMVLLKRYVLRSISEFPVKYDIYGNIIN" sig_peptide complement(37285..37374) /locus_tag="ClothDRAFT_1818" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.461 at residue 30" misc_feature complement(36025..37287) /locus_tag="ClothDRAFT_1818" /note="endoglucanase; Region: PLN02308" /db_xref="CDD:177943" misc_feature complement(36025..37284) /locus_tag="ClothDRAFT_1818" /note="Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959" /db_xref="CDD:186543" gene 37944..40379 /locus_tag="ClothDRAFT_1819" CDS 37944..40379 /locus_tag="ClothDRAFT_1819" /inference="protein motif:PFAM:PF06165" /note="PFAM: glycosyltransferase 36; putative carbohydrate binding; glycosyltransferase 36 associated; KEGG: sde:Sde_1318 cellobiose phosphorylase" /codon_start=1 /transl_table=11 /product="glycosyltransferase 36" /protein_id="ZP_05429958.1" /db_xref="GI:256004986" /db_xref="InterPro:IPR009342" /db_xref="InterPro:IPR010383" /db_xref="InterPro:IPR010403" /translation="MKFGFFDDANKEYVITVPRTPYPWINYLGTENFFSLISNTAGGY CFYRDARLRRITRYRYNNVPIDMGGRYFYIYDNGDFWSPGWSPVKRELESYECRHGLG YTKIAGKRNGIKAEVTFFVPLNYNGEVQKLILKNEGQDKKKITLFSFIEFCLWNAYDD MTNFQRNFSTGEVEIEGSVIYHKTEYRERRNHYAFYSVNAKISGFDSDRDSFIGLYNG FDAPQAVVNGKSNNSVADGWAPIASHSIEIELNPGEQKEYVFIIGYVENKDEEKWESK GVINKKKAYEMIEQFNTVEKVDKAFEELKSYWNALLSKYFLESHDEKLNRMVNIWNQY QCMVTFNMSRSASYFESGIGRGMGFRDSNQDLLGFVHQIPERARERLLDLAATQLEDG GAYHQYQPLTKKGNNEIGSNFNDDPLWLILATAAYIKETGDYSILKEQVPFNNDPSKA DTMFEHLTRSFYHVVNNLGPHGLPLIGRADWNDCLNLNCFSTVPDESFQTTTSKDGKV AESVMIAGMFVFIGKDYVKLCEYMGLEEEARKAQQHIDAMKEAILKYGYDGEWFLRAY DDFGRKVGSKENEEGKIFIESQGFCVMAEIGLEDGKALKALDSVKKYLDTPYGLVLQN PAFTRYYIEYGEISTYPPGYKENAGIFCHNNAWIICAETVVGRGDMAFDYYRKIAPAY IEDVSDIHKLEPYVYAQMVAGKDAKRHGEAKNSWLTGTAAWNFVAISQWILGVKPDYD GLKIDPCIPKAWDGYKVTRYFRGSTYEITVKNPNHVSKGVAKITVDGNEISGNILPVF NDGKTHKVEVIMG" misc_feature <37944..40376 /locus_tag="ClothDRAFT_1819" /note="Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459" /db_xref="CDD:33262" misc_feature 37944..38132 /locus_tag="ClothDRAFT_1819" /note="Putative carbohydrate binding domain; Region: CBM_X; pfam06204" /db_xref="CDD:148044" misc_feature 38139..38462 /locus_tag="ClothDRAFT_1819" /note="Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165" /db_xref="CDD:148020" misc_feature 38487..38753 /locus_tag="ClothDRAFT_1819" /note="Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205" /db_xref="CDD:148045" gene 40644..41603 /locus_tag="ClothDRAFT_1820" CDS 40644..41603 /locus_tag="ClothDRAFT_1820" /inference="protein motif:PFAM:PF02826" /note="PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: tdn:Suden_0034 2-hydroxyacid dehydrogenase" /codon_start=1 /transl_table=11 /product="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" /protein_id="ZP_05429959.1" /db_xref="GI:256004987" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /translation="MLKICVLDAKTLGDDVDLTVFDKFGPVQVYAETKPEEVVERIKD VDVVITNKVVLNKENLENASKLKLICVAATGTNNIDLEYAAQKQIAVTNVAGYSTMSV VQHTFAMLFYLMENLPYYDRYVKSGEYAKSNIFTHHERPYHELAGKTWGIIGLGTIGR AVANAAEAFGCRVVYYSTSGKNNNTQYERAELEKLLKESDIVSIHAPLNNNTRGLIDY ERLRMMKKSAIILNLGRGGIIREEDLARALDEELISGAALDVLEKEPVNCDNPLLGVK NSDRLFITPHIAWASVEARKRLVDEIALNIEAFIEGKERNRVC" misc_feature 40647..41585 /locus_tag="ClothDRAFT_1820" /note="2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410" /db_xref="CDD:181414" misc_feature 40962..41507 /locus_tag="ClothDRAFT_1820" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" gene complement(41707..41820) /locus_tag="ClothDRAFT_1821" CDS complement(41707..41820) /locus_tag="ClothDRAFT_1821" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429960.1" /db_xref="GI:256004988" /translation="MSEGRGFGFFGDNSEILFFILVFLLLFFNGNYGYREE" gene 42163..43038 /locus_tag="ClothDRAFT_1822" CDS 42163..43038 /locus_tag="ClothDRAFT_1822" /inference="similar to AA sequence:KEGG:Caul_3093" /note="KEGG: cak:Caul_3093 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429961.1" /db_xref="GI:256004989" /translation="MMLLADDWKDYELIDTGNGEKLERWGKYILRRPDPQIIWPIRNE NGLWKKADAHYHRSRSGGGSWEFKRKLPERWTISYHDLSFYIEPTGFKHTGLFPEQAV NWKWMIDKIRSASRNINVLNLFAYTGGATVACAYANASVCHVDAAKGMVQRAKENLAL SGLADRSVRFIVDDVIKFVQREKRRGRQYDAVIMDPPSYGRGPRGEVWKIEDELYGFV EQCIDVLSPKPLFFLINSYTAGFSPTVLANILKMTVVKRFGGVVTCGEVGIPVSSSGI VLPCGIYARWEAQKK" misc_feature <42205..42972 /locus_tag="ClothDRAFT_1822" /note="Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092" /db_xref="CDD:31289" misc_feature 42517..42864 /locus_tag="ClothDRAFT_1822" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440" /db_xref="CDD:100107" misc_feature order(42529..42549,42595..42600,42679..42687,42745..42747) /locus_tag="ClothDRAFT_1822" /note="S-adenosylmethionine binding site; other site" /db_xref="CDD:100107" gene 43035..43730 /locus_tag="ClothDRAFT_1823" CDS 43035..43730 /locus_tag="ClothDRAFT_1823" /inference="protein motif:PFAM:PF00849" /note="PFAM: pseudouridine synthase; KEGG: sfu:Sfum_1153 pseudouridine synthase" /codon_start=1 /transl_table=11 /product="pseudouridine synthase" /protein_id="ZP_05429962.1" /db_xref="GI:256004990" /db_xref="InterPro:IPR006145" /translation="MSSCGNNGIDIIFEDNHLLVVKKPVNIPTQKDKSNDSDMLTLLK EDIKKRYNKPGNVYLGLVHRLDRPVGGVMVFAKTSKAASRLSDQVRTRQFKKVYLAVV HGILDKLEGRLENYLLKDTRNNTVSVVKEDTPGGKLAVLDYKVEGIYNGFSLVKVSLH TGRPHQIRVQLANIGHPLYGDQKYGHGVNKPGQQIALWSSEIAFVHPVLKQEMIFSCE PPEVEPWTWFNRV" misc_feature 43086..43646 /locus_tag="ClothDRAFT_1823" /note="PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869" /db_xref="CDD:30029" misc_feature order(43221..43232,43536..43538) /locus_tag="ClothDRAFT_1823" /note="active site" /db_xref="CDD:30029" gene 43818..44036 /locus_tag="ClothDRAFT_1824" CDS 43818..44036 /locus_tag="ClothDRAFT_1824" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429963.1" /db_xref="GI:256004991" /translation="MKQLTASEILFVSKLLQLESADLSVLKATLPFVSDKELKELIKT SVKNSEARINGLRQFISDNDVMVAGGVQ" gene 44039..44347 /locus_tag="ClothDRAFT_1825" CDS 44039..44347 /locus_tag="ClothDRAFT_1825" /inference="protein motif:PFAM:PF07875" /note="PFAM: Coat F domain protein" /codon_start=1 /transl_table=11 /product="Coat F domain protein" /protein_id="ZP_05429964.1" /db_xref="GI:256004992" /db_xref="InterPro:IPR012851" /translation="MASILENIFGQNMSKPTDETIAYNLMAGAAAAATAYLTATLDTV TPELRRLLNDYTNQIILQHGTLTKLAVEKGWFLPYETPMKQLQISLANTQSIIENNAQ " misc_feature <44165..44278 /locus_tag="ClothDRAFT_1825" /note="Coat F domain; Region: Coat_F; cl02368" /db_xref="CDD:154876" gene 44653..46095 /locus_tag="ClothDRAFT_1826" CDS 44653..46095 /locus_tag="ClothDRAFT_1826" /EC_number="2.4.1.21" /inference="protein motif:TFAM:TIGR02095" /note="KEGG: pca:Pcar_2954 glycogen synthase; TIGRFAM: glycogen/starch synthase, ADP-glucose type; PFAM: Starch synthase catalytic domain protein; glycosyl transferase group 1" /codon_start=1 /transl_table=11 /product="glycogen/starch synthase, ADP-glucose type" /protein_id="ZP_05429965.1" /db_xref="GI:256004993" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /translation="MKKIKVLFASSEVDPFAKTGGLADVASSLPKALCKLGHDVRVVM PKYKDIPFQYVEKMQKVGEIGVYVSWRRQYCGILKLEMDNITYYFIDNEYYFKRDGYY GYYDEAERFAFFSKAVLEILPVIGFKPDIIHCNDWQTGVVSAFLNAWYKGLDFYKDIK TVFTIHNLKYQGIFPKEVFGEVLGLPWDYFHADGIEFYDKVNYLKAGIVYSDIITTVS KTYAEEIKTDFFGENLNNVLRKRSNDLYGILNGIDMEENDPAVDNRIFANYSVDNLEG KLTNKQMLQKSLGLQERIDIPLIGIISRLVAQKGFDLIDYVMDEILKMDIQFVLLGAG EYRYEQMFRYYQEKYPGKISVNLKYDAVLAQRIYAGADMFLMPSLFEPCGLSQMFSLR YGTIPIVRETGGLKDTITPYNDITHEGNGFTFSRYNAHDMLYAIKEAVHYYYHRSTWT YLMKKGMTTDFSWEKSAKEYLELYEKLAGN" misc_feature 44665..46092 /locus_tag="ClothDRAFT_1826" /note="glycogen synthase; Provisional; Region: glgA; PRK00654" /db_xref="CDD:179083" misc_feature 44665..46080 /locus_tag="ClothDRAFT_1826" /note="This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791" /db_xref="CDD:99965" misc_feature order(44704..44706,44713..44715,45556..45564,45724..45729, 45742..45744,45793..45795,45808..45810) /locus_tag="ClothDRAFT_1826" /note="ADP-binding pocket; other site" /db_xref="CDD:99965" misc_feature order(45319..45321,45853..45855,45868..45873,45877..45879, 45952..45954) /locus_tag="ClothDRAFT_1826" /note="homodimer interface; other site" /db_xref="CDD:99965" gene complement(46320..47267) /locus_tag="ClothDRAFT_1827" CDS complement(46320..47267) /locus_tag="ClothDRAFT_1827" /inference="protein motif:PFAM:PF00248" /note="PFAM: aldo/keto reductase; KEGG: mxa:MXAN_6482 aldo/keto reductase family oxidoreductase" /codon_start=1 /transl_table=11 /product="aldo/keto reductase" /protein_id="ZP_05429966.1" /db_xref="GI:256004994" /db_xref="InterPro:IPR001395" /db_xref="InterPro:IPR005399" /translation="MKYRKMGRTGLYISEISLGSWLTYGNSTDKETAVKVIDTAYSLG INYFDTANVYANGRAEVIVGEALKKYPRESYILATKAFWPMGTGPNDKGLSRKHVFEQ VHASLKRLNVDYIDIFYCHRYDPETPLEETLRTIDDLLRQGKILYVGVSEWTAAQMAQ ALYIADRYLLDRIVVNQPQYNMFHRYIEKEIIPFGEKNGISQIVFSPLAQGVLTGKYK PGGNIPRDSRAADPNSNMYIGQFLKEDKLLKVEKLKAVADEMGITLSQLAIAWVLRQP NVTSALIGASKPEQVEENVKASGINLSDEILNKIEAILQ" misc_feature complement(46329..47261) /locus_tag="ClothDRAFT_1827" /note="Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660" /db_xref="CDD:119408" misc_feature complement(order(46386..46391,46398..46400,46413..46424, 46473..46475,46638..46655,46737..46739,46812..46817, 46902..46907,47028..47030,47106..47108,47121..47123, 47205..47213)) /locus_tag="ClothDRAFT_1827" /note="active site" /db_xref="CDD:119408" misc_feature complement(order(46905..46907,47028..47030,47106..47108, 47121..47123)) /locus_tag="ClothDRAFT_1827" /note="catalytic tetrad; other site" /db_xref="CDD:119408" gene 47480..48838 /locus_tag="ClothDRAFT_1828" CDS 47480..48838 /locus_tag="ClothDRAFT_1828" /inference="protein motif:PFAM:PF05673" /note="PFAM: protein of unknown function DUF815; SMART: AAA ATPase; KEGG: ppd:Ppro_2113 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF815" /protein_id="ZP_05429967.1" /db_xref="GI:256004995" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008533" /translation="MLINVNFNELLLELDSLSVYRNLLNDSVIKKLYELGDLIYKKEP GTDEFIKKYNEFFFELTSGSIQSLKEHIIELILFDENPYSRQSEKLPFENIDKVLIDA ASKDLDRLHVISALTSRKFKDYALENICKSESEKRFIDSLPAWEFDGRSNQGKRKLSQ NCQKMIDVLVSSNKWGECVKNLSDFYFTNGSGIFARYHAFVWEPSEKPSLRGVEFPDP IRLSDFIGYEQQRLEVIENTEKFVRGLPANNVLLYGDRGTGKSSTVKAIANEYREQGL RIIEIPRKYLVDFPAVLKLIKGRSCKFIIFIDDLAFEDSEESYTVLKSVLEGGVENRP DNVLIYATSNRRHLIKEKFSDRAGFKSDDPDDEIRAQDTMQEKLSLSERFGITVVFSS PDKKQFLQIVEGLVAKRGINIDKDTLQREAMKWELMYNGRSARTARQFVDWLEGSMKL KK" misc_feature 48059..48829 /locus_tag="ClothDRAFT_1828" /note="Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607" /db_xref="CDD:32599" misc_feature 48176..48532 /locus_tag="ClothDRAFT_1828" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009" /db_xref="CDD:99707" misc_feature 48239..48262 /locus_tag="ClothDRAFT_1828" /note="Walker A motif; other site" /db_xref="CDD:99707" misc_feature order(48242..48265,48401..48403,48509..48511) /locus_tag="ClothDRAFT_1828" /note="ATP binding site; other site" /db_xref="CDD:99707" misc_feature 48389..48406 /locus_tag="ClothDRAFT_1828" /note="Walker B motif; other site" /db_xref="CDD:99707" gene 49039..50247 /locus_tag="ClothDRAFT_1829" CDS 49039..50247 /locus_tag="ClothDRAFT_1829" /EC_number="1.1.1.42" /inference="protein motif:TFAM:TIGR00127" /note="KEGG: dps:DP0778 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase, NADP-dependent" /protein_id="ZP_05429968.1" /db_xref="GI:256004996" /db_xref="InterPro:IPR001804" /db_xref="InterPro:IPR004790" /translation="MSKIKMKVPLVEMDGDEMTRIIWRLIKENLLEPYIELNTEYYDL GLENRDKTEDQVTIDAARAIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAI LDGTVFRAPIVVNSIKPFVKGWKKPISIARHAYGDVYKNVEYYVPSAGKAELVFTSEN GEVSRQTIHEFDGPGVIMGMHNTDKSIRSFARACFNYALDMNQDLWFSTKDTISKTYD HRFKDIFQEIYENEYKEKFEAKNLQYFYTLIDDAVARIIRSEGGMVWACKNYDGDVMS DMVASAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKHLKGEETSTNSMATIFAWT GALKKRGELDGIKELVDFATKLEQASVQTIENGVMTKDLASLSEVPEKKIVNTEDFLK EIRKTFEGMA" misc_feature 49039..50235 /locus_tag="ClothDRAFT_1829" /note="Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445" /db_xref="CDD:185999" gene 50248..50355 /locus_tag="ClothDRAFT_1830" CDS 50248..50355 /locus_tag="ClothDRAFT_1830" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429969.1" /db_xref="GI:256004997" /translation="MILHIMDLLTRYGIIKAIPGYFIATYITIDILLYI" gene 50489..51763 /locus_tag="ClothDRAFT_1831" CDS 50489..51763 /locus_tag="ClothDRAFT_1831" /inference="protein motif:PFAM:PF02518" /note="PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; KEGG: psa:PST_3882 sensor histidine kinase/response regulator" /codon_start=1 /transl_table=11 /product="response regulator receiver sensor signal transduction histidine kinase" /protein_id="ZP_05429970.1" /db_xref="GI:256004998" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /translation="MQEPVYTILIVDDNENNLFSLRTLIEEHINADVKEANSGEKALK ILFKERVDLIILDIQMEGMDGFELASIIKKRKKTSSIPIVFLTASYIGDEFQRRGFEI GAVDYLTKPIDEYQLINRINVYLKMIEKERTMNILLEKRVREQTEELRAAKEAAEAAN EAKSIFLANISHELRTPINILYSTTQIINSYLNEDKVLDREKIRSKIAMQQQNCYRLL RLVNNLIDITKIDSGYFELKFSRCNIVEVVENITLLVVEYAKNKGVSLIFDTDVEEKI ISCDQNAMERIILNLLSNAIKFTPRGGSIKVEVKDCGKTVAISVKDTGIGIQEDKLEM IFERFKQVDNLLTRKNEGSGIGLSLVKSLVELHGGKISVKSEYNRGSEFTVELPADLE NGENPSMDAADRKEENENKQHNVHIEFSDIYY" misc_feature 50513..50863 /locus_tag="ClothDRAFT_1831" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature order(50522..50527,50657..50659,50681..50683,50747..50749, 50807..50809,50816..50821) /locus_tag="ClothDRAFT_1831" /note="active site" /db_xref="CDD:29071" misc_feature 50657..50659 /locus_tag="ClothDRAFT_1831" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature order(50666..50671,50675..50683) /locus_tag="ClothDRAFT_1831" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature 50816..50824 /locus_tag="ClothDRAFT_1831" /note="dimerization interface; other site" /db_xref="CDD:29071" misc_feature 50984..51175 /locus_tag="ClothDRAFT_1831" /note="Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082" /db_xref="CDD:119399" misc_feature order(50984..50986,50996..50998,51008..51010,51017..51019, 51029..51031,51038..51040,51095..51097,51107..51109, 51125..51127,51137..51139,51146..51148,51158..51160) /locus_tag="ClothDRAFT_1831" /note="dimer interface; other site" /db_xref="CDD:119399" misc_feature 51002..51004 /locus_tag="ClothDRAFT_1831" /note="phosphorylation site" /db_xref="CDD:119399" misc_feature 51338..51649 /locus_tag="ClothDRAFT_1831" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(51356..51358,51368..51370,51377..51379,51446..51448, 51452..51454,51458..51460,51464..51469,51548..51559, 51605..51607,51611..51613,51626..51631,51635..51637) /locus_tag="ClothDRAFT_1831" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature 51368..51370 /locus_tag="ClothDRAFT_1831" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature order(51458..51460,51464..51466,51548..51550,51554..51556) /locus_tag="ClothDRAFT_1831" /note="G-X-G motif; other site" /db_xref="CDD:28956" gene 51808..55125 /locus_tag="ClothDRAFT_1832" CDS 51808..55125 /locus_tag="ClothDRAFT_1832" /inference="protein motif:PFAM:PF02518" /note="PFAM: ATP-binding region ATPase domain protein; GAF domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; GAF domain protein; KEGG: cvi:CV_1579 two-component hybrid sensor and regulator" /codon_start=1 /transl_table=11 /product="GAF sensor hybrid histidine kinase" /protein_id="ZP_05429971.1" /db_xref="GI:256004999" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /translation="MKLLKNVRIQHRMWALFAVWLILYVIFAVAAYRNVSEIGQVSED IYTQSLKTSNAAREARVAIMKIQRGIKEILLSDNPDNVYYELEKIRELDNQVLENFEI IKSNSGGNEEIEKLVNESTEIFDEWRKTRGEIAALIQQNKHLQDTTALTVKNNEFVEK LEKCLDSLDKIEEDEAQNLIDRSAKIQKYHKNSIFYWTGIIVFTSVVLFTIVIRSIMW PVSYLQHIMRTSANTREIIEAELPGKNELVNMANYYNKLVRNLKEQFWIKDSCSALNE ELAGKFDLKEITDKAVTFLARILDAGNGVLYLYNDEDKKLYLNSSYAFTERDRLSNQY ELGEGIIGQVALERKPILLKNVKRQEALITTGTVTEAPLNVYAVPLLYQGHLYGVLEL SSFEPFVELKQELMNEAAKIVSTYLYTAVQNNRIVNLLKITEAAKQEAGRKASELEEA NRVLEEQQILLQKQTEELQQTNIQLEYQQQKLQQQSEELQQTNSQLEEQQQLLEEQAR LLNIKNEDLERTTRELRLRTEELEKVNKYRSEFLANMSHELRTPLNSIILLSKMLARK KINEFDEKDMEKIEVINKAGQELLRLINDVLDLSKVESGKMNLNIFTFHSSELMEDLR QMFESSAKEKNISFFVEDSINSMLVGDRDKISQILRNFLSNAFKFTSEGSVILKAEMD KDRENDVIFSVTDTGIGIPEEHISDIFQEFRQVDGTISRKYGGTGLGLSISKKLADLM KGEIEVRSKIGEGSTFFLKLPGLVCKKEDGREKVTVKKDMDRKISTDRKNDKVILVIE DNENFAKYLKEINDGMGFDTIIAGSGKEGLETAKNTRVDGILLDIMLPDMSGIEVLRE LKSIVELGKIPVHVISDLEEDDVSQIIAYLLNYSARHPERIMIVGGDAIWQSTIKKPF EERNITTKTVSTEEEVKFEFKKEMYDAVILNMELDDKDVAGICEYIAEQNVDIPLIVY AEKSLSQERQKEIKKYADKIIIKTADSKERFQDELTAFLKGIKENMDNGCYLFSKVKK EYALNLDGKTIMIVDDDHRNVFVLAAALEDYGANIIAAENGKMALELLRTNKVDLILM DIMMPVMDGYETIRAIK" sig_peptide 51808..51900 /locus_tag="ClothDRAFT_1832" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.759 at residue 31" misc_feature 52654..53058 /locus_tag="ClothDRAFT_1832" /note="GAF domain; Region: GAF; cl00853" /db_xref="CDD:154040" misc_feature 53410..53610 /locus_tag="ClothDRAFT_1832" /note="Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082" /db_xref="CDD:119399" misc_feature order(53428..53430,53440..53442,53452..53454,53461..53463, 53473..53475,53482..53484,53539..53541,53551..53553, 53560..53562,53572..53574,53581..53583,53593..53595) /locus_tag="ClothDRAFT_1832" /note="dimer interface; other site" /db_xref="CDD:119399" misc_feature 53446..53448 /locus_tag="ClothDRAFT_1832" /note="phosphorylation site" /db_xref="CDD:119399" misc_feature 53770..54087 /locus_tag="ClothDRAFT_1832" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(53788..53790,53800..53802,53809..53811,53884..53886, 53890..53892,53896..53898,53902..53907,53986..53997, 54043..54045,54049..54051,54064..54069,54073..54075) /locus_tag="ClothDRAFT_1832" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature 53800..53802 /locus_tag="ClothDRAFT_1832" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature order(53896..53898,53902..53904,53986..53988,53992..53994) /locus_tag="ClothDRAFT_1832" /note="G-X-G motif; other site" /db_xref="CDD:28956" misc_feature 54190..>54441 /locus_tag="ClothDRAFT_1832" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature order(54199..54204,54331..54333,54355..54357,54421..54423) /locus_tag="ClothDRAFT_1832" /note="active site" /db_xref="CDD:29071" misc_feature 54331..54333 /locus_tag="ClothDRAFT_1832" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature order(54340..54345,54349..54357) /locus_tag="ClothDRAFT_1832" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature 54931..>55122 /locus_tag="ClothDRAFT_1832" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature order(54940..54945,55072..55074,55096..55098) /locus_tag="ClothDRAFT_1832" /note="active site" /db_xref="CDD:29071" misc_feature 55072..55074 /locus_tag="ClothDRAFT_1832" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature order(55081..55086,55090..55098) /locus_tag="ClothDRAFT_1832" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" gene 55447..56556 /locus_tag="ClothDRAFT_1833" CDS 55447..56556 /locus_tag="ClothDRAFT_1833" /EC_number="2.1.1.80" /inference="protein motif:PRIAM:2.1.1.80" /note="KEGG: cvi:CV_1580 two-component hybrid sensor-regulator protein; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type" /codon_start=1 /transl_table=11 /product="MCP methyltransferase, CheR-type" /protein_id="ZP_05429972.1" /db_xref="GI:256005000" /db_xref="InterPro:IPR000780" /translation="MHISVMGELDSKADVDRLLESIDENCDCEIHLTFLDANVVPREI VEKIVKLKEHNKCKIFVLKAYLYSYFLSLGISCFLVKKKSILNKDFESKEKLSSQTFE PEKVEKFLWDIYDKYGFDFTEYRKDSIIRRIKISMLRYCMTNFDEFSHLALTDQDVFE QLFLDFSINTTNFFRDPEVFMFLREKVLLFLDSYSHIRIWCVGCSNGKEPYSLAIILK ELGMLHKVQIYATDINPYVIEEAKNGLYSVSTINTDIANYKKSGGSKNFTDYFEVNGN YMKVKDDFKDNILFFQHSVIEKGILNEFQMILCRNVMIYFDIPLQKKVLRHFYNSLDS GGFLVMGKSEGMLLNNGYEYFADYNEKYSVYRRKH" misc_feature 55765..56553 /locus_tag="ClothDRAFT_1833" /note="Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352" /db_xref="CDD:31543" misc_feature 55951..56517 /locus_tag="ClothDRAFT_1833" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011" /db_xref="CDD:187159" gene 56630..58987 /locus_tag="ClothDRAFT_1834" CDS 56630..58987 /locus_tag="ClothDRAFT_1834" /inference="protein motif:PFAM:PF06733" /note="PFAM: DEAD_2 domain protein; SMART: helicase c2; Helicase-like, DEXD box c2 type; KEGG: ppg:PputGB1_2943 DEAD_2 domain-containing protein" /codon_start=1 /transl_table=11 /product="DEAD_2 domain protein" /protein_id="ZP_05429973.1" /db_xref="GI:256005001" /db_xref="InterPro:IPR006554" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR010614" /db_xref="InterPro:IPR014013" /translation="MNEYKKEIKISVRNLVEFVLRTGDIDSSFTGSSRAVEGTRLHKK IQKTQGKEYSPEVFLKTTVEFDDFFLTVEGRADGVINEDGCFIIDEIKTTTAPLELID EFYNPLHWTQAKCYAYIHALNENLEKIKIRLTYCHLETEEIKYLVSEFDFAELSRFFE ELVEKYYVWAKLACDWQVKRDCSIKVLEFPFEKYRKGQRKLAVAVYKTVTEGKKLYVK APTGIGKTISTLFPAVKAIGEGHASKIFYLTAKTVTGGVAKEAFAKMRQKGLLFKTVT LTAKEKICFMEKAVCKPEKCEYAKGHFDRVNEAIMDILTNEDEIKREVIEEYAKAHRV CPFELALDLTIWADAVICDYNYVFDPRVYLKRFFSDAGGDYIFLVDEAHNLVDRAREM FSAQLSKKSFLELKKAMKEESPKISKTLQKLNTFMLGMKKLCGDNDYFVSKEEQSEIY LLLRRLIGECEEYLTDRAKNGIENEDLLQLYFDALMYVRIAEFYDDRYVTFVEKSDND VRIKLFCIDPSHLLSEALKRGKAAVFFSATLLPLSYFKEVLGGGPDDYTMCLDSPFEV NNRCLMIADRISTRYQDRGKSCDEVVQCIKSIVCAKKGNYIAFFPSYQYMNMIYELFE KECGDIKLYVQSSSMTEKEREDFLERFKADPQETVLGFCVLGGIFSEGIDLRDDRLIG AIIVGVGLPQICIERDIIRDYYQNKNRLGFEYSYMYPGMNKVMQAAGRVIRSENDKGV ILLIDDRFTNPSYLALFPNEWFPYIRVTGNNISEHVKKFWSRHGA" misc_feature 57188..58948 /locus_tag="ClothDRAFT_1834" /note="Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199" /db_xref="CDD:31392" misc_feature 57443..57832 /locus_tag="ClothDRAFT_1834" /note="DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029" /db_xref="CDD:175389" misc_feature 58466..58873 /locus_tag="ClothDRAFT_1834" /note="helicase superfamily c-terminal domain; Region: HELICc2; cl09250" /db_xref="CDD:142194" gene 59058..60344 /locus_tag="ClothDRAFT_1835" CDS 59058..60344 /locus_tag="ClothDRAFT_1835" /EC_number="1.1.1.3" /inference="protein motif:PRIAM:1.1.1.3" /note="PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: gbm:Gbem_3019 homoserine dehydrogenase" /codon_start=1 /transl_table=11 /product="Homoserine dehydrogenase" /protein_id="ZP_05429974.1" /db_xref="GI:256005002" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /translation="MEEVKIGFLGFGNVGTGAYKIIRDNGNDIFLSEGVRLKVAKILV RDINKKRNVEVDNSILTDKFEEIVDDPGISIVAEFMGGVEPARDYVVSCLKNKKTVVT ANKELIAKHGLELQALAKENGVGLYYEASVAGGIPVIKILAESLQANKIGEIMGIING TTNYILTKMSEEGRSFSDVLAEAQRLGYAEPDPTADIEGYDAMYKISILSSMAFHKKV DVDKIYREGITQITPEDIEYGRELGFAIRLLAIAKKRNNTIEVRVHPTFIPLDHPLAA VRHSFNAVFLKGDAVGNIMLYGRGAGDLPTGSAIVSDIITACHQKDKHRYISFYNDEE GSAEKIKFNDDWESEFFVRLTVKDKPGVLAKIAGCFGKHGVSIASVIQKDRGKDAVPL IFVTHLAKELSMKKAISDIAEVEDVLMVENIIPVER" misc_feature 59058..60338 /locus_tag="ClothDRAFT_1835" /note="homoserine dehydrogenase; Provisional; Region: PRK06349" /db_xref="CDD:180538" misc_feature 59085..59444 /locus_tag="ClothDRAFT_1835" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature 59466..60002 /locus_tag="ClothDRAFT_1835" /note="Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742" /db_xref="CDD:144371" misc_feature 60105..60338 /locus_tag="ClothDRAFT_1835" /note="ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881" /db_xref="CDD:153153" gene complement(60635..61276) /locus_tag="ClothDRAFT_1836" CDS complement(60635..61276) /locus_tag="ClothDRAFT_1836" /inference="similar to AA sequence:KEGG:SYN_01448" /note="KEGG: sat:SYN_01448 thymidylate kinase" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="ZP_05429975.1" /db_xref="GI:256005003" /translation="MAYLDDYAFLIWALIELYETTYKPMYLKKAMELTNDMIKYFWDN KKGGLFIYGSDSEQLITRPKEIYDGAIPSGNSVAALNFLRLSRLTGQQELEEKAHQMF ALFGSKIDSMPQGYAFFLTAMLFSKSKSNEVVLVGSNEKDTQNMLSILSEDFRPFTTS ILYSEEHKDLKELIPFIDNYTTIENKPTAYVCENFVCHEPITDGALLREKLNR" misc_feature complement(<61040..>61234) /locus_tag="ClothDRAFT_1836" /note="Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338" /db_xref="CDD:150114" misc_feature complement(60719..>61006) /locus_tag="ClothDRAFT_1836" /note="DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106" /db_xref="CDD:186338" gene complement(61230..62678) /locus_tag="ClothDRAFT_1837" CDS complement(61230..62678) /locus_tag="ClothDRAFT_1837" /inference="protein motif:PFAM:PF03190" /note="PFAM: protein of unknown function DUF255; KEGG: dal:Dalk_2829 protein of unknown function DUF255" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF255" /protein_id="ZP_05429976.1" /db_xref="GI:256005004" /db_xref="InterPro:IPR004879" /translation="MSAYKQANRLIHEKSPYLLQHAYNPVDWYPWCDEAFEKAKRENK PIFLSIGYSTCHWCHVMESESFEDEEVAEILNKNFVSIKVDREERPDIDSIYMTACQA LTGHGGWPLTIIMTPDKKPFFAGTYFPKKDRMGMPGLISILKSVHNTWVNEKDSLAKY SSKVVSVISESIDDDYYYSVDEITEDIFEDAFSQFKYDFDNIYGGFGNAPKFPMPHNL YFLLRYWHKAKEEYALVMVEKTLDSMYSGGIYDHIGFGFCRYSTDEKWLVPHFEKMLY DNALLAIAYLETYQATKNKKYADIAKEIFTYVLRDMTSPEGGFYSAEDADSEGEEGKF YIWSPTEIKEVLGESDGEKFCKYYNITEEGNFEGLNIPNLINSTIPDEDKEFVELCRK KLFDHREKRVHPHKDDKILTAWNGLMIAALAIGGRVLGIEKYTLAAEKASEFIFSKLV RPDGRLLARYRDGEAAFFGISRRLCILNLGSY" misc_feature complement(62229..62594) /locus_tag="ClothDRAFT_1837" /note="TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955" /db_xref="CDD:48504" misc_feature complement(order(62505..62507,62514..62516)) /locus_tag="ClothDRAFT_1837" /note="catalytic residues; other site" /db_xref="CDD:48504" misc_feature complement(<61287..61865) /locus_tag="ClothDRAFT_1837" /note="LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955" /db_xref="CDD:156404" gene complement(63163..63609) /locus_tag="ClothDRAFT_1838" CDS complement(63163..63609) /locus_tag="ClothDRAFT_1838" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: rle:RL2959 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429977.1" /db_xref="GI:256005005" /translation="MSDSILKLIPSIPSFIPNSTAQIALMEYLNSIFSNTKIKISITN NIEFIDCGENFQEVVCPYCKQPLNMEWWGETMSILYEKHFIEAFFELPCCSQTTQIFD LIYKENCGFSKFVIEVFNPEIKLTVPQLSELEKILGCELKVINAYY" gene 64505..>64755 /locus_tag="ClothDRAFT_1839" CDS 64505..>64755 /locus_tag="ClothDRAFT_1839" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: pen:PSEEN0728 acetyltransferase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429978.1" /db_xref="GI:256005006" /translation="MQIHFNNKNDKEYQFMLNNLLKDIFLDFQFWYDLNLWDENYESY SIVENGEIVSNICVYKTQILFNQKQYCALSVGAVATKKE" ORIGIN 1 tcttgttttg tggggtgcat tgtttaatga acagagataa caggcctaca ggaagacaaa 61 aacgcatagg ctcaggtacc ggtaacgtca gccggcgcgg cagtggtttg ggttcgggac 121 ctgtaggtag accgggggga tattctgaca ggtccaaagg aaccgggaca agtggaagaa 181 gcggcccggc aagaagcttt ggcagttatg gaagttacgg aggctacgga ggttattcgt 241 ccggcagacg gagaaggtct tccggttgtt caaaatactt gacaatactc atattgattc 301 tggcaattgc atattacata tacagtaatt ttggtggagg ttcgggaaac tcaacttcaa 361 ccaacaattt cctgaacgga acgtcttcgg tttccggtta tgttgacaaa ggcgagtatc 421 cggttgatac cactgtgtcg gagcttgccc gtgcgaaaag gaccgtttta aaaggcaatg 481 gagaagatat agcaaccgta atgatataca tgtgcggtac cgaccttgag tcaaaatggg 541 gtatggccac cgctgattta aaagaaatgc tcaatgccga gatttccgac aaagtaaata 601 ttattgtgga gaccggcgga actttaaagt ggcagaacaa taccgtagac agcagcacaa 661 accagcgctt taaagttacc aatgacgggc ttaagctttt ggaaggcaat ttgggcaaaa 721 aatcgatggt tgagccggag accctttcgg attttataaa atattgcaag acgaactttc 781 cggctgaccg ttacatgctt atcctgtggg atcacggcgg aggttccgtc agcggttacg 841 gttatgatca gcattatcca agcaatacaa tgaggcttga tgaaattgcc gttgccctta 901 aaaacggcgg ctgtgttttt gacctgatag gctttgatgc ctgtcttatg gctacgcttg 961 aaacagccat tgtactggaa ccttatgcgg actatatgat tgcttcggaa gaggttgaac 1021 cgggaatcgg atggtattat accggttgga taacagctct ttcccgaaat acatcgataa 1081 aaaccattga ccttgggaaa aagcttattg atgactatgt aaaggaagta agggcgaaaa 1141 cgccgagcag ccaggccaca ttgtcgcttg ttgacctggc ggagctcaaa ggtaccatac 1201 cgcaggcctt tacaaagttt gcaaaatcaa tagacacact ggttaccaga aatgaatata 1261 agactgtatc caatgcccgg gcaaatacga aggaatttgc aaaatcatcg aagataaatc 1321 agattgatct tattaacttt gctgaaaacc ttggtaccga tgaagggaaa aaacttgccg 1381 aggcattgcg cgggtgtatt aaatacaacc ggacatcgaa aaacataaca aatgccaacg 1441 gtttgtcaat attcttcccc tatggaaatc tttcaaaggt aaactcaatg cttgatactt 1501 atgaacagat aggtatcgat aaagagtaca gcaaatgtat aaaaagtttt gcaagcgtgt 1561 cggccggagg acagattgtg tcaagcggca gcaataatat gcttgaagtc ctgctgggga 1621 gctttacgga aggttcttca aattccggcc agtccttgac taccgccgct ttggaaattt 1681 tgctggagga attcttaaat tccggaaatt acggcaggat tacgggtgga gaaagtgatt 1741 ctctggattg gctggatgtc aatcttatga agtcttccgt agattattac aggaaaaacc 1801 ggtttgaccc ttcggctctc aagataaccg aaaagaacgg gcagagggtt ctgtcgatgt 1861 cggaggaaca gtggagtctt gtccagcaga tggaaatgaa tgttttcata gatgatggag 1921 aaggatttat tgaccttggt cttgataatg tatacgaatt caatgaagac ggagaccttg 1981 tgatggaatt tgacggaaca tggcttgctc taaacggcaa tattgtaagc tactacatga 2041 taagtgatga ccgccatggg gatacttatt cgacaaaagg aagaatacct gcattgctga 2101 acggtcagct tgttgacatt attgtggtgt ttgacaatga aaatccttac ggaaaagtgc 2161 ttggagccca gataaggtat gacacaaagg ccgagactga aactttggca aagggactta 2221 tagatatagt tgcaggagac aaaattgatt tcctttgcga ttactacact tatgaaggtg 2281 agtacataga tacctatttc cttggagagc agtatacggc aaccggtgag tggaaaatag 2341 agaatttgca tcttgggtac agggattacc agatgaccta ccgcataacg gacatatacg 2401 gcaacaagta ctggacaccg tctgttacaa attagcggta ttggatgatg cggaaatgtg 2461 gtgattttat gatagaaatt aaaggaaaat ataatacggc aaaagttttt accaacaacg 2521 ttgaaccgga ggcaatggct cagatattgg aactttgcaa ccaggagttt gtaaaggaca 2581 gtgtaatcag aattatgcct gatacccatg ccggtgcagg ttgtaccatt ggaaccacca 2641 tgaccattga cgacaaaatt gtgccaaatc tggtgggtgt tgatataggc tgcggaatgg 2701 agaccataaa gctgaaaaat aaaaatattg aattgagcaa gctggacaaa gtaattcatg 2761 aatttatccc gtcgggtttt gacattcgca aaaaagagca tccgtatgtc aggaatatta 2821 atttggatga gctattgtgc aaaaaacacg tggatataaa ccgggcaaag ctgagtattg 2881 gcaccttggg cggtggcaac cattttattg aggtgaacaa agacagtgag ggaaacctgt 2941 atcttgtggt gcattcggga agcagacatc tgggaaagca ggttgcggag tattatcagg 3001 agttgggtta caaggagctt gtaaaaaaca ctgaagtgat taaagaaatt atagcaaagc 3061 tgaaagcgga aggccgtgaa aaggaaatcg agaaggaaat aaaaaaaatc aagccgccga 3121 atataagcaa gcagcttgcc tatgtccagg gcaaaagtta tgaggactat cttgccgaca 3181 tgaaattggt gcagaaattt gcggtattga accgcaaagc aattgtggat gagattgtga 3241 ggcgcatgaa ttttaaaatt gaagagcagt ttaccactat tcataattat attgacttag 3301 acagcatgat actcaggaaa ggtgccattt cagcacgcaa aggggaaaga gtgctgattc 3361 cgattaacat gagggacgga agccttatct gtatcggcaa aggcaacaag gattggaact 3421 attccgcgcc ccatggggcg ggaagactga tgagcagggc taaggcaaaa gaagttataa 3481 cgcttaagga attcaaagaa tcaatgaagg gaatttattc aacaacggtc aacaaatcca 3541 ccattgatga atgtcccatg gcttacaagc ctatggagga aatcattgaa aatattcagg 3601 acaccgttga aattgtagat attattaagc caatatacaa ctttaaagcg gctgaatagg 3661 caaaaatacc atttttcatg tacaaatatg aaaaaattct atataattat aactgtatat 3721 ggagagattg agtgtgaatg atagaaaaaa tttgataaat cttgctgttt tccttttggt 3781 tgctttgtta tcgacgcttc ttattatggc cgctataagt atgttggatt tgcgtgggaa 3841 cgggtcgcct ggaggtgaaa ataataagag ggcttcccaa aatgacggaa gcggcaaaaa 3901 tcgcaataag caggaccgaa ataataacaa taaaaacaaa aaaggaagcg gccaaaggga 3961 ggatgacaac ggttccaact ggaaggaaag ggctcaaaga aggcgtggcg agagaagaag 4021 ttttgacagg ggagattatg cttatgggca aggacccgaa agcatgattc ccggagacgg 4081 atgggaatat gatattgcgc ctgatcaaat gcccaatctt gacatatccg gcaatgaagg 4141 actgcccgac atgtcttttg gaatgggtgg caatacgttt gttttaaaag agggcaaaaa 4201 ttcccacata cctgcttttg aagttttggg tgttcccaat tacccttttg taagagttat 4261 ggctatggac aactatcgtc ggagtcactg gagtatgata aacgaagctc cggagctgat 4321 gtttttgttt ggggagaaag tggacagaaa attttccgaa aatactgtca agataaagcc 4381 tgtggagcct tcaaaggggt atattccggt attgtcgggc aactttgaaa tgaaatatga 4441 gtttagcctt ttggaatata aacaatccgg agtcttttat tccaccggag ttattgaaaa 4501 tttttacgaa atgaagtacg aggatcctcc gacggaagcg gaattgatta atgcaaaaac 4561 cgatgatgat tactattatg atatttatgt gcctgaagtg gtcgagagaa tagttgatga 4621 agtgattgaa aattgcgaaa ccgactatga ggcaataaaa tttgttgaga aattcctttt 4681 ggaaaactac acttatgata acactgtgct gaacaattac ggaagcggcg atgcggtggt 4741 ttcattcctt acaggaaaag acagggtggg aaaccatctg gattttgtat ctgcctatgc 4801 cattatttta agggctgcgg gcattccatg cagacttgcg ctgggctata aacttttgcc 4861 cggtgtcaaa taccaggtgg tgtatgcaga tcaggtctat atttatcccg agataaagtt 4921 tgaggattat ggatgggttc cgatggacgt tttcccctat gatgtttttt accgtccgcc 4981 gaaagaaaca ataacccaaa ttacttttgc cgacggtacg acaaaaaggg gagaaaccgt 5041 tacggtaaga ggaactgtta cggattcatc aggcaatccc atagacaaca tgacggttct 5101 tgtctatttg aaacaataca agagcgagcc gtgtatttct tatgcgaaag cctatgtcac 5161 aaacggcaac tttgaagccg tgttcgatat aaaaggggat ataagtgcag gaaagtatca 5221 tattattgcg gacgttctgg aaaatgatgt ttacaggaca tcctcaagcg accccgaact 5281 taaaattctt gcggatactt ttattgatct ggaggaacgg agtgatataa tcggcaacaa 5341 actgaatttt gcaggaagga ttgttgactt ttttacctat gaaggaatag aaggccttga 5401 ggtccatgta tcctttgaag gaatggattt ggttgagacg gttgtgtccg aagaagacgg 5461 aaaactttac aaagagattg aaattgaagt tcctgaggat tatccatact ataaaaactt 5521 tttttttgca ggaagatatt tgttgtttta cggtattgaa tttaagggaa ctgagatata 5581 tactccctat ttcacaagaa ggggagtgta tatgtggaag atatactgga taaacgttac 5641 tgttgcggtt gttttgcttt tgggcgttgt acttctttgt gttgcaattg tgctgaggaa 5701 aaaaggagca ttccggaggg acggcggaaa atttcccgtt ttggccgcgg aaggtccggg 5761 aatgattgtg gcagcggatg cgggagcgga atcggtggaa agaaaccatg gcaaagttta 5821 tatagagttt ccccaaattg gggagggttt acccgatgta tggggaataa aagaaaattt 5881 ggccgttgtt tttcatgacg acgaaggcaa caggggagag attggggcgg tattccataa 5941 aaaaggggag tacagaatca aaatttccgg gaaaaacgac gaatacggcg caagaaacat 6001 acggatagtt gactacaggg aagaaataat tgcaatcgga aagaattttt taaaagaaat 6061 gtccgcaaag atttcaggaa ttaccgattt catgactcta agggaaatac atgatataat 6121 taagccgaac attgcttccg aaaggcattg ggttttggaa gatgctttca tggtgtttga 6181 aaaggctgtg tacagtgatg aggatattgt aagaagtgat tatgaaaagt tttatgtttt 6241 tgccagagaa cttggaaaaa acagctcaat ttaagtcgtt ggaggggttg aatgcgggca 6301 ggaagcagat tgaaggggga tttgccgtta aataaattaa taatttattc tgtagttacc 6361 ttggtttaca tggcacttac ggttctgata ttttttatac cttcgggacc ggcgtataat 6421 tccagagaaa attattattt tttgatattc tccgttgaag tgtttcttgt gggacttacc 6481 gccaggcact ttgcagatta tttttttaaa gggaaatggg ccaaagtgct gagtgactca 6541 tgctttgtgt ttggaaacgg agtttccgtg tttttctttt ggattttgct tccgtttgat 6601 ccgcagctga aactggcagg ctgtggaata ataccgataa cagtttcgat tataatttac 6661 aaaatttcaa aactttatga aaacaggatg cttgaagggg aaatcattaa aataatttca 6721 tacttgatgg ccggattttc cgcttatttt atgtttaaaa ctctttggcc cgaaagcagg 6781 ttgggcaatt tgactctcta ttctttcatt gtactttgtg tttttgagct tgcatcgttt 6841 gtggaactta gcggaaacaa aaaagcttat ggtgctacag gttggcttag gtcaaaccat 6901 gcaggcaagt tttttgttgc gtttgtaacc ttgtttgtag tactggattt aaggaggatg 6961 gtaatgtttg aatcggtttt gggtgtatgg atttttatat ttttgtttct ggttgttatt 7021 tttatcatat ttaccataaa gctttcggca gctgcgaata acagtccgga ggaaaggctc 7081 ggcaagcatc ttcagaggat aaactttgac aagataaggg atatttccga cataacctca 7141 catataaatg attttgtgta taatggaagc aaaagcggac ttatagcctg tctttttatc 7201 ataatgaaca aagccggcgt tccgatattt gcagcaaaaa gaataattgc gcccgttgtg 7261 gaccacaagg atcttgaaat gccttctttt atgaccagaa aggattacat ggttattgag 7321 gaaagaaaca agcaaagaag aatgaaagtt gtggaaactg ttattaaaaa tttggaagta 7381 tacggaaggg gaagttataa tggtttcgga acaggttcaa gcattgtgca aaaatataat 7441 tgatgaagtg ggaaaggtat ttgtcgcaga caatgacgtg attttaagaa aaatactttg 7501 cggctttctt gcgggaggac acatactttt tgaggacaat cccggacttg gaaaaacctt 7561 gcttgtaaag gtttttgcga aggttacggg ctgtgaatgg aagaggatac agtttactcc 7621 cgacctgatg ccttcggata ttttgggtac aaaaatctgg aagggcaact cttcttcttt 7681 tgagcttgaa aaaggcccaa tatttaccaa tttccttttg gctgatgaga tcaacagagc 7741 gatgcccaaa acccagtccg ccttgcttga ggccatggaa gagcggcagg tttcgataga 7801 gggcgtaact taccagctaa aacctccgtt tattgttatg gccacgcaaa acccgataga 7861 aatggaaggg acatatccgc ttccagaagc gcagatggac agatttataa tgaaactatc 7921 cctcgggtat ttagcaagcg ccgaaaaaga gtgtgaagtg ctaaagagaa ggattgagtg 7981 gagaaaagat gatccaacct gtgacataaa gcctgtaatt acgatggagc agcttttgat 8041 gctccaaagc gaagtggaaa aggtttatgt ggatgacaat attcttatgt atataacgga 8101 gatagtaaga aataccaggg tcaatccaaa tataagactg ggtgcaagtc cgagaggggc 8161 actggctttg ttgaagctgt ccagagccca tgctcttgtc agcggaagaa attatgtaat 8221 tcctgacgat gtcaaattta tggccgtgga tgctcttgcc catcgtgtta ttttgcatat 8281 tgagcgtata atggaaggaa gggttgccac ggcagtgata agaagcattg taaccaagac 8341 agaggtgcca aaaagtttca caagggaaaa tgcaggaggg cttttgtaaa tgccgaaggg 8401 tgtctcaaaa acgggtattg tgtttttgtt actgatttgt gtgggttttc ttcttgccaa 8461 caacatactg atacttgttt ccattattcc atttacgtta atggcttttg ggtattattt 8521 aaaaatgccc gacggtatca gggttgacaa gactgtgtcc aaaaacaggg ttacggtcgg 8581 agaactgctg gaggtatctg taagagtact ggtagagtcg ggatttggtt caatggaaat 8641 atgcgatatt gtgcccccgc attttgaact ggtggaagga actaattact gtgcagtgtg 8701 gaaagggttt gagccgaaag aaatactctt aaattatact gtccgctgta cagcatcggg 8761 aacttataca ttcaggacca ctggctggag agccagacat gctgtgggag ctttttcgat 8821 aaacagaaaa tatgagacgg atttgacggt agaagtgacc ccaaggctta ttgaactcaa 8881 gaaggtaagg ggcatgtcca cggtgtgcaa agttccgatg ccggagggag ctttggcaag 8941 catgggaatg acaacccagg aatttaagga actcaggctc tattctcccg gtgacccgtt 9001 taaggcgata aactggaagg ttacgtcgag aaatttggtc aggggcagta tctggcctgt 9061 ggtaaatgag tttgaaaaag aaggaaagaa gtctgtgtgg atatttttgg atacgtcaaa 9121 aataatgtcc ttcggttcca acataaaaaa tgtcaaagag tattctgttg aggctgtaaa 9181 cagtcttagc gactattata taaaacacaa ctgcagtgtg gcttttcata cctttggagg 9241 aagcgatgtc tttataaatc ccgggtcggg aaggcagcag cattacagga ttttaaggga 9301 gcttatgaaa ataaggaatt tcaccggagt atcccgggaa aattccgggg agcgtcaaaa 9361 aaactccaag gagcacaaaa aactggaaga ggcagtgtat tcgtgcagaa attattttaa 9421 cggactgaga ccaatgttta taattattac aagattttgc acaaaaaatt ccgaagaaat 9481 tttcaaaggt ataaacctta tgtcaaaata cacttcgctt cgaaagggct atgttcccag 9541 cataatgttg ataaatataa tggggtatgg tcttatggct gaaaatgaga atgaaatgat 9601 ggcggcaaat cttcttgagg ccatgaacaa agtgctttcg gaaaagataa gaaaaaattg 9661 tatctggatt gactgggacc ctaacaagga aagccttaca ggtgcattat taaaacaggt 9721 ggtgggttaa aggttgaagg tgtggacgtt gtcggctcga attttgttat caattgcggc 9781 ttatgtgttg tcctatattc tttttgtctg ttcatccatt tattgggacc ttgtattttt 9841 atttaaaaca cagagcagag tttttataat aataaatatt gtagctttta tcataatcgg 9901 gctgtgttac aataagtttg aaaaagcagt cggtgtgata tgcatgctct ttgcggctcc 9961 ttctgtgttg gttcattcaa aaatgctcaa aagtgagccg gcagagtcag tatatacgag 10021 atattttcca ctccacttga ccgccctttt atttttgata attactgttc ttttaatggc 10081 ggcaataaga cttcaaaaac tcgacagaca gtatgatgaa atgatatccg gcggtgcgtc 10141 ggaggccgat gtaaagttaa taattcttaa caatatcaaa gtgtattccg tttttcttgc 10201 tgtaattcta ttcagcggat ttgttcttgt tgctttggcc tttgcaatgt ctaaaatcaa 10261 agcaacgcgg ttgactgtaa ttataacggt aacaaccggc gttgtgctgg ttttagggtg 10321 tgtactgtat ttgtacagaa aatggactaa aaaatagtaa tttaataaca agtttttgtt 10381 atatatattt ttttaatttt atggtataac cttaaaaact ctgtttttat tttccgatat 10441 acataatata ttccgatatg ttcttgtgag tcttgtgaaa tcattccata tcactgaaat 10501 aattcatata cataatataa tatattttaa ggagaagcct tatgaaaaag cgcaggacga 10561 ttggtttttt ggttaacgac atagatgtaa gctattccaa tttggtttac cttatgacca 10621 aaaaggccgc agaaaaatat gactgcaacc ttattgttta tgaaggcaga tctttcaaca 10681 acccttccat ggcagacagc cagcatcaaa tatcctacag ctttgttgac aatacccgtt 10741 tggacggaat aataattaca agtgccacga ttgcgtgctt tatttccgat gaggaatttg 10801 tagaattttg caaacgttat gaaggaatac ctttggtatc gctgggaatt gttgttcccc 10861 atgccaccag tattcttgtg gacaacaaac cgggaatgaa aagccaggtg gaacatctta 10921 taaaagacca tggttttaaa aaaattgttt atatatccgg tcctccgaca aatacggatt 10981 cggtcgaacg tcttgaagca tactgtgaag cgctgaggga aaatgatatt gaggtagatg 11041 acggtctgat attttacggg gattttatgg cacaatccgg atatgacatt ataaaagaga 11101 taataaagaa cggcattgag tatgatgcgg ttgtttgtgc aaatgatgag atggcttttg 11161 gagcgataaa aggtataagg gacttaaaag acgcttataa tctcgactta acccaaaaag 11221 gtgtgatatg cggatttgat gattccataa cgtcgcgact ggtcaaaccc tctttgacta 11281 cggtaagaca gcctattgaa gaaatgtgtt tttatgcggt tgaggcaatt cttaaaaaaa 11341 tagaaggaga aaaagttgaa gatgtggtga aacttccttc tgtcctggtt aaaagggaat 11401 cctgcggctg taaaaacgcg gccgaagtgg attttgtgag tgacagcagt ctaagacttg 11461 ttcccggtca gaggatacat gagaatttgc agacatattc cctggatgaa ttatttgact 11521 gtattaccag aacattaaaa ctgtgttcca tcagaagctg ttttattttc aaatattgcg 11581 gcggaacttt gctgtatgag gttgattcta ttttcagaga cgattttaga ctgcctgagg 11641 attccgaatt gatatatgct tactataatg acgagagaat aaccatagaa gacagtatta 11701 aatatataaa aacaagatgc attataccgg accggttctt taacgaagac aggcggttta 11761 catatttggt taatccattg tttttttatg acgaacactt tggttatgtg tgttttgaag 11821 tagcaaatga tgatgtactg aactttgaac ctatcagggg tcagataagc aacacgttaa 11881 acggtgcgct gatgctcatg gaaagagcca agatggaaga aagcctcagg gagacggaac 11941 gtcttgcttc gctggggcag cttatcggag gaatttccca caatcttatg actcctataa 12001 tgtccatatc cggagcatgc tttggattgg aagaccttgt gcatgaatat atggcatcta 12061 tagaagaccc ttccgttacg gtgcaggacc acaaggaaat agccagggac atgcaggagt 12121 ggataaacaa actcaaagaa tacaattcgt acatgtcgaa tgttattgca acggtcaaat 12181 cacaagcggt ccagcttaat tccgatgcga ttaacgagtt tacaatcgaa gagcttgtag 12241 acagagttaa atttataaaa aacaataacc cccagatcag aaaagccgtt ttaaactgca 12301 aaattgatat tgacggtaaa acggcaattc gaggggatat atccaatctg gcacagataa 12361 ttgaaaatct cttgattaat gcagtgcagt cttatgaagg aatggataat gccagtaaca 12421 ttgttgatct ccatatattg aaagaagaaa atatggtcaa atgtattgtc agagattatg 12481 ggaaaggcat acccaatgaa ataagagaca ggctgtttag gcgaatggta accacaaaag 12541 gtaaaaatgg aacgggactg agcctgttat tgtcctattc cacaataaag ggcaagttcg 12601 gaggggaatt gtgggtggag tcaaaggaaa acgaaggttc tgcgttttat gtaacgatac 12661 ctttgaccga cagggaatga ttgcataagc tttggggttt ggaaaaagta cggattaaaa 12721 aactttgtgt tttatgacga aaatatatta gcagcaagtc gtcggactac gcaacatact 12781 tgtttgggag atgatcgctt tgatggagtt gaaggaaatt ttaaaaatgg gtgttgataa 12841 taaagcttct gatatacatt tgactgtggg aagggctcct tctttcagaa taaacgggaa 12901 aatgaaaacg tttactgaca atatactgtc tccggaagat acaatgagct atgccaaaga 12961 gtgtttggac aaggaaaagc ttgagcatct tatggctgtg ggagaagttg atttttcaat 13021 gacggttccc ggaatttcca ggttcagggt gaatgtgttt tttcaaaggg gctctgtggc 13081 aatagtattc agaatacttg cttccacaat accgactctg gattctttga attttcctga 13141 agtgattaag gacatttgca aaataaaaga agggctcata cttgtaaccg gccccacggg 13201 aagcggaaaa tccactacca tggcttcaat tatcaatgaa ataaactcta ccagggaagg 13261 gcatatattg actcttgaag accctatcga atatattttc aagcatgaca aatgtgtcgt 13321 aaaccagagg gaaatatccc aggacagcaa gtcctatgcc agtgctttaa aagctgcctt 13381 aagagaagac cccgatgtga tattcatagg ggagatgagg gacaatgagt ctataagtat 13441 tgcggttacg gcggcagaga cggggcacct ggttctttca accctgcata ctctgggtgc 13501 ggctaaaacc atagacaggc ttattgacgt ttttccaccc caccagcaac agcagataag 13561 ggtccaggta tccagtgcgc taaaggcggt tatatcccag agattgattc ccgatattga 13621 taacaaagga agagttgcgg ctcttgaaat aatgattgtt actccggcaa tcagcaatct 13681 cataagggaa ggcagagtgg caggaattac ttcaatgatt cagacgggtg cggcccaggg 13741 gatgaaactt ctcgataaat ccatagccga actctatcag caagggcgca tatcaaaaga 13801 aagtgcatac gaatactgtg cggacagaga gcttctaaaa aggtttatag ggtagcggcg 13861 tacaaagagt atttggttgg aattttcata attgcaattt ttcattatta atagtattat 13921 taaaactgga ataatatatg ttttttttta tatttgtatt tgtttttggg gggagatgtt 13981 tttcatgaga aagtatgggt taaaaaagat tgtttggatg cttggcattt tatgttttct 14041 ggttgtgtct ttaaatacct caatttttgc agcggacggt aaaaatgtgg ttttaggcga 14101 tgtcaacgga gattccaaaa taaatgcaat tgacgttttg cttatgaaaa aatatatact 14161 caaagttata aatgatttac cctccgacgg tgtgaaagca gcggatgtaa atgctgacgg 14221 tcaaataaat tcgatagatt ttacatggct gaaaaaatat atgttaaaag ctgttgagaa 14281 atttcccgga gaagcaagca ataatcctga cgctgttatt cagtttgaat ccggttttgc 14341 ccattcggtg cttttgaaaa aagacgggac cgtatgggtt ttgggaaaca acggcaaagg 14401 acagttggga cttcccgaag tatcggccgt aaatgagcct gtcatgataa acggtctttc 14461 aggaataaaa tcggtggctg cgggaaggga gcatacactg gcattgcagg aagacggtac 14521 tttgtgggcg tggggaaaca attacagcct tcaactcata gagtatatgg aaagggatcc 14581 tgatacaaaa gagagattta caagtattcc gattaaagtt gagactcatt ccgatatcaa 14641 atatgtggcg gctaaatttt cacgtaccct catagtaaaa aatgacggta ctgtttggct 14701 gtattcgctt cctcctataa atacctcctc ggatgccgag tacatgccgt gggaaataaa 14761 aggctttggg gatataaaga tggcggatat tgggacagga catatagttg cactaagaga 14821 agacggaacg gtgtggacct ggggtgaaaa tgtctgggga caattgggta acggttggca 14881 gcagcaccac aacattcata cttatattta ttttgagccc aatcaggcaa agaatctctc 14941 ggatattgtt tcgatagccg cgggagatgc tcattcggtg gcattgaaga gtgacggaac 15001 tgtatggact tggggcagca acttcaacgg cgagcttgga aacggtacga ctacttatat 15061 tttggagcct aaaaaggttg aaggtttgga ggatatagta gccattgatg ccggaatcgg 15121 ccatacggtg gcgttgaagg ctgacggaac ggtatgggtg tggggtaaaa acagctatgg 15181 tcagctggga aacggcacaa ccatgagaag cactgttccg atacaggtag aaggacttga 15241 aggaattgtg gcaatacaag caggtatgga gtgcacgata gcatataaaa atgacggaac 15301 ggtatgggca tggggtaaaa atgattttgg acaattaggt gacggaactt ttgaaaacat 15361 attaaggccc gtaaaagtat ttgaaagaaa atgattgaat caggaggaaa tgtttaagtg 15421 agtttacaaa atagatttaa gagtttgcat tataattcac cggttattct gacaatgacg 15481 cttttgtcgc tgggagcgtt gatacttcag aacattaccc gtggctacac aacttcgttg 15541 ctgttttcag tctatcgcag cagtcccttc agtatatttt tctatttcag gctttttgga 15601 cacgtgctgg gacatgcaaa ctgggagcat tacatgaaca actttcttct tattttgctt 15661 cttgggccta tgcttgaaga aaaatacggc tccaagagaa ttgcttttat gatagcggta 15721 acggccgtgg ttacaggagt tataaacata ctgctttttc ccagaacagc ccttttggga 15781 gcaagcggag ttgttttcat gtttattctg ctaagctctt ttgttaattt taaaaaggga 15841 agaataccca taacctttat acttgttgtt ataatttatc tgggaggaga ggttatgaac 15901 ggtatttttg taaaagacaa tatttcacag ctagcccatt tggtgggagg aatctgcgga 15961 agtgtgtttg gttttaaatg ggcggaaagg tcgtcctggt agctgaaaat cggaaaataa 16021 aatagagctt tttgtttgct tttggaccgc ctgacaggag agtggcggtt tttttatgcc 16081 tttatattgg ggaaatttgc catcagacat tctgttggtt gacattaaaa aactattatt 16141 gttaacaata ttactctaaa aatatcggga tttttttccg aaataactaa tagagtatgt 16201 ttattcgtga atgggggata aaatatgaag ataaccggag tcatagtaag aatacataaa 16261 gacagagcta ttattcggac agacgataac agattgcttg ccgtaaaaag acacaatgac 16321 atgatggtag gccaaatagt aagctttgac gcaaacgaag tgcataaagt tgagagcaaa 16381 aaatacaaat atgcagcttc gggcaaacgt atcgaaaaag ttcaaaaaac ccccaagata 16441 aagaattttt caagaataaa caatatcaag gaattttccc gcgttgacga cataaaaaat 16501 ttctcacgcg tagcggcaac caaagagact tcacaggact caccgcagga gtcaaaagtg 16561 gagaactttt cccgtgtagt ggacttttca cgggtgatga acttctcacg ggtgtcaaac 16621 agtaagaaaa acgaaataaa gaatttctca cgtataagca acatcaaaaa cttctccaga 16681 atagcatcga ttgcggccgc ttttgtgctg atattcctgt ttggtcggaa tgtgatgctg 16741 aacaatagtt caggcagtga atatgcttat gtcagcgttg atgttaatcc aagcgttgag 16801 tttacgataa acagtaaaca taaagttatc gtcacatccg caataaatca agatgcgtca 16861 gaagtattgg atggccttga actgaaagag aaagacctga agtctgctct tgtgatggtt 16921 cttgaaaagg cagaatcgct gggctatatt tcggatgata agaactatgt acttgtttcc 16981 atggctctga atgacaagaa caaaaaaacc agggataaaa gggaagaaaa gattgatgag 17041 ctgaaagaga ctatagaaca gggaatagaa gcgctggaca atgatactat tgtccacagg 17101 acagtgactg tggaccttga ggaaagaaat aaggctttgg aaaatgaact gtcaatggga 17161 agatattatc tgtatctcga agcaaaagaa aaaggtatgg acattactat tgatgaagtg 17221 aaatcttcaa agatttctga tttgatagaa aaaatagagg ataataccga gctggctcct 17281 acgccaacac cggtaccacc agaaacaccg gagccgactc cgacacctac ggcatccgag 17341 gcaacaccgt caaattcacc ggttgagagc aagtcaccgg aagctgtgcc cgaacttggc 17401 tcaagggaaa tagaaatcct gggtgaaagc gtggttttgg taacggccta tgacgagaac 17461 aggaaggttg tttcccaggg cagcggtttt gctgtcggaa cagggttgtt tgccacaaac 17521 tatcatctgg ttaaagacgg tgtggttgtt aaaataacgg cgggtgacgg aaaagtatat 17581 gatgtggacg gaattgtaaa atacgacaaa gcgaaggatt tggctttgct gaaaaccaca 17641 gttgaaactg gtgtgaaccc acttaagctt ggtacaaaga aatctttgac caaaggcagc 17701 aggattgtgg caataggcaa ggcaaatgga gctaaaaaca ctgtgacgaa aggaagtata 17761 aagagcctta aggttgacgg cctgaccgac gcaattgaac tttcggcttc aatttcaaag 17821 gaaagtaccg gcggtcctgt gtttgacatg aaaggaaatg ttgtaggaat aactgcttat 17881 ggaatttcaa aacaaaatgt caatgctgtg attccggcag actatgtagc tgactgggta 17941 aaagagcttt cgaaacattc ctttggcaac atcagaattg taaggaaaac tcttgtattt 18001 gacagtgact ttgagttcaa ttttgtggtt tacaaaataa taagggcgct ggaaaatgaa 18061 gatgctgcca catattttgg ctgcatgacc gatgaattgt acaaggatga aacaaggaaa 18121 aatctggaag tactgtttac aacttacgac cttgcttata acatagaaag tatcaatgtt 18181 gtttcaaaga gtgaagaaca ggcaaaagta agctatgttt atacaataaa caaagaagcc 18241 ggtccgaact ttaaaaatta cagaataatc ggagaatgca gcctcataaa ggttgacggc 18301 acatggaaaa tcaatgattc ggaggaaaag aaagagtata tacaatagtt ggacaataag 18361 aaagctatac caatgttgta attcagagtt ataattgctg gaattcaatt ttataatttg 18421 cctgggttat aatattatat aatgttttgt ttgataaaga atacttgctt tggtataatc 18481 attagaaaac caaggtttat agaggtggat aatgattaaa tacaaagcgg tattctttga 18541 ttttgactat acgctggcag attcatctaa agctgttata gaatgtatta actatgcact 18601 gcaaaaaatg ggttatcccg aatcttctcc ggaaagtatt tgcagaacaa taggacttac 18661 gttggccgag gcttttaaaa tacttagcgg ggatacttct gattccaatg cggacctttt 18721 ccgccaatac tttaaagaaa gagcagatct ggttatgtgt gaccggactg taatgtacag 18781 cactgttgaa tgtgttttga agaagctgaa aaaggcggat gtaaaaacag gaattgtttc 18841 aacgaagtac agatacagga tagaggatat attaaaaagg gacaaacttt tacagtattt 18901 tgatgtaatt gtcggcgggg aagatgttgc ggcccataaa ccggatccgg aagggcttct 18961 aaaggccata tcgatggttg gctgccaaaa ggaagaagtc ctttttgtcg gagacagtac 19021 ggtggatgca aggactgcaa aaaatgcggg agtggatttt gtggcggttc ttacggggac 19081 aaccggggca aatgagtttt cagagtataa tcctggtgct gtgattgaag atttgagtgg 19141 tttattggat atgtttatgt tataatcaaa tatatagttt gatttgaatt gagaagtacc 19201 tggtgatgat agggggaaag tgtatgagta tcagtgaaat ggcgtttcag gtcaaggagg 19261 cttctatcag gcttgcggca gcaggtaccg aattaaagaa caaagccctt gagaatatag 19321 ccagactgtt aatggagaga aaagacgaga ttataaaggc aaacaatgaa gatttacaga 19381 gaagcaggga ggaaaagctt gcagaacccc ttcttaagag attgaaattt gatgaagcca 19441 agattgtgga tgtgatagac ggtattaaca gcttgataaa gctggaggat ccggtgggaa 19501 aaacccttct ttccactgag cttgacgagg gacttgagct ttatagagtt acctgcccga 19561 taggagttgt gggaataatt tttgagtcaa gaccggatgc ccttgttcag atttccacgc 19621 tgtgtcttaa aagcggaaac ggtgttcttt taaagggggg ttccgaggcc cgggagacca 19681 ataagatact tgcccaaatt attaccgagg ccactgaaga agttggaatt ccgccaaact 19741 ggataaaact tttggagact agggcggatg taaatgaaat gcttaaaatg gacaaatata 19801 ttgacctaat cattccaaga ggttcaaatg agtttgtaag gtatattatg gataattcca 19861 gaattcctgt aatgggccat gcggacggaa tatgccattg ctatatagat gaggatgccg 19921 acattgacat ggcaattcgg attgttgtgg attccaaaac ccagtatgtt gctgtctgca 19981 acgcaacgga gacattgctg gttcataaaa atattgctcc gaaagttctg cctgagctga 20041 aaagagcttt ggacagcaaa aatgtggaac tggtgggctg cagtgaaaca cagaagatta 20101 tacctgttgc cccggcaacg gaagaggact ggaggacaga gtatcttgac tacaagctgt 20161 ctgttaaagt agtcggtgat ctggaggagg ccatagaaca tatcaacacc tatggttcgg 20221 ggcatactga cagtataatt acaaacagca aagaaaaggc ggcagcattt atgtcccttg 20281 tagattcggg caatgtcttc tggaattgct ccacacgctt tagtgatggg tttaggtatg 20341 gttttggcgc tgaagtcgga atcagcacaa gcaaaattca tgcaagagga ccggtgggac 20401 ttgacggatt gttgatttac aagtacaagc ttatcggcaa tggacatatt gtggaggatt 20461 atgccaaaag gacaaaaagt ttcaaacata ataaaatgaa caagcaattc cctctataat 20521 acaggtcctt tatctttgaa cttctttaag tttactgaaa actttttaca gattgggtta 20581 aaaccctgca aagtcacttt atagtgatgt ttgcagggtt ttttatatgc aatgtaacaa 20641 gtgcagatag gtatacataa aatgtattag actttcagtt tttatccttt gagtttttgc 20701 aaatgttttg tttttatttc tgtttttaat attgctgctc tatgtgctgt gtaacccttg 20761 aagaaattaa ggggagggga caatatgaat taccaggaaa tagagaaatt aaaagccgtg 20821 ctgaccaaga tgatgaaaaa gggctgtatg cttatgattc cggcctatgg agcagaagga 20881 agaattgtaa gtattggatt caggccttat tggacaaatc ccggtgactc aaaaatagaa 20941 aaacttgaga tcaattttgt tgacaacaga ggcagagtag tacccctttg tatttacagt 21001 attattggtt acgagattgt ttcttttgag ggaagaagtt tggaagatgc gaaaaatatc 21061 agtcttgaca tccattctta tgccaatgtt aaggggagga aagcggaaaa atatgatact 21121 ctgcatcttg aaataggtga aatatccgat gagtgatttt aaataatgct gttttatatg 21181 taaccattaa aaatagatta acataatatg tatcaaggaa actaattgaa aataaagtgg 21241 aaaggtggga catagaatgg ctgaggaaat cagaggctat ggggatgcaa gcttgcctgc 21301 tttgctgtca aagcatattg gtgagactgt aactattttt acaaaaagtg gaggacaatc 21361 cggtgcaggc tttacaggag taattctctc cgtaaacgac tgctttgtac gccttattac 21421 aagaattggg cctcctccgg catgttccct tggcaatgca tgtacaaact ttaatgttga 21481 ccatggctac gattacaaga atccgttcgg ttcatacgat tgtggtcatg gttacggaaa 21541 aggacatggt tatatacagc ctgccagtga acttggaaca gtctcggccg gtggatggaa 21601 cggatatccg gtatacactg tcggctcggt aactgatatc ccgatatcgg caattgtatc 21661 tttcgtacac aacgcagtat aatcagtttg cttgaaggaa aacccgggga tggtttgctc 21721 ccgggttttt taagttttta cgtgttattt taatatatta atccaatttt gttattgaca 21781 aaaatctgcc atgttattaa aatactttta atcaatcaat acggttttta aaatgtatcg 21841 atacacattt aagcataaag ggtatctgtg tgcattaata atgcaaagca taaaaatcta 21901 aaaaacaata ataaaaagag aggtggatta taatgaacaa accgttagta atgactccgg 21961 gtccaactta tgttcatgag gatgtaagaa gagccatgca acaggaagtg ggaaatccgg 22021 atgtggagga gagctttttt gaattttaca gggaaacatg tgaaagacta aaggaacttt 22081 taaaaacaaa gaatgatgta attatattgt caggagaagg aattttgggt ttggaggctg 22141 cctgtgcttc agttattgaa ccgggagaca gagttttgtg tattgataat ggcatattcg 22201 gaaacggatt tggcgatttt gtaaagatgt acggaggaga agctacatat ttgaaatttg 22261 attatcgccg ggctgttgat gtaaatgtgg tcgaaaattt tcttaagaat gaccacaatt 22321 ttaaagctgc aactcttgta cattgtgaaa ctccttcggg aataacaaat cccatagccg 22381 atatttgcaa aatgctaaaa aggtatggaa ttttatccat cgttgatgcg gtttcctcaa 22441 taggaggaga gcctttggaa gcagatgaat gggagattga tgttgtactg ggaggctctc 22501 aaaaatgtat ttccgcaccg ccgggactga cttttatgag tataagccga gatgcatgga 22561 atgccatatt gaaaagaaag acaccgataa taggttatta ctgcaacctg gcagtatgga 22621 aaagctggta tgaggacagg tggtttccat acacacaacc ggtcagtgat atttacgcgt 22681 taagagcggc cgttgacaga ctcttacagg acgacctgcg aattgagaga cataaaaaca 22741 ttgccgacag ggtaagggct gctttggcag acagagggtt ggagttgtat cctgaaaatg 22801 gtttttccaa tacggttaca gctttctatg tacctgatgg tgcaactttt accgatatat 22861 acaatataat gctcagtgaa cacaatatat taattgcagg ctcttttggt tttttgaagg 22921 acaaggtgat acgaatcgga catatggggg aaaattgtta tgaagacaag attttgaaaa 22981 cttttgccgc tttggacaag acatttgaaa aactgaatat tgatttaagg aacaagttgc 23041 ctggttcacg gtaatatgtt ccattatgca attctgattt taaaaaagga tttttgagaa 23101 cggtgtcgaa tataattttc atactattgt caaattacga gcgcagtgat gcaacaggca 23161 ttttattttt tatgcatttc tgtttctgtg tgtgcccata atctttgtca ggttgttttg 23221 ctgacagaat agtttgtttt gctaatacca attatttaat gaaaaggcag gtaacggata 23281 tgaaggaaat tactctggaa agtcatgcca gaagagtgaa caaagttctc ctatttattt 23341 tctgggcata tttttttgtg tgtatagttt taggaatgac tatcactgca cctacttccc 23401 tgatcagtat tgaaagtatt ccgctgataa tttttttcgc aggcatgatt acttcaacaa 23461 tttactttgt caaaaggaaa tataacgaca ttaccggtct gattttatgt ctgtcagtta 23521 tggtttcgct tgtagccacc tattttaatc tgaattctgt ggtcgaggaa actatgattc 23581 ttgtattggt aatacctgca tgtgccatgg ctctgtattt aaacaagaga aattttgcga 23641 tttatgcagt ttgtttcaat ttgctctgtg taatttttga ggcagtatat aaaacaatgg 23701 gtatgcagaa atttatttca gatttggtta aaattgattt tattttgttg tttttatatt 23761 tttccgccaa atggggaagt gaaataatcc atcaaatgat agaaaaagag aagaattcaa 23821 ataatatact gaataaactg gaagatacca tgggatttct gagaaaaaat actgaaattt 23881 taaaccgtga cataatgaat tgcaatatga ctttaaaaat gattaaggaa tcgggcgaca 23941 gtgttgcact ggcggtggaa gaggttgcga aaggtattag tgaggaagct gaaagcgtca 24001 gtaatattaa tgttatgatg tcggaagcag ataaattagt ggctgatacg gccgcaattt 24061 caagggaaat ggctgaagtt tccgtttcaa ccgttcagat tgtaaatgaa ggtgttaaaa 24121 atataaatga aatgaataaa caaatggaca ttattaacac tgcggtaaat gaatcttact 24181 caacggtact aaagcttcag gagagcatgg acagggtaaa tgaatttctg cagggaatta 24241 cggagatagc cgagcaaacc aatatgttgg ctttaaatgc gtcaattgag gcggcaagag 24301 caggagaatc gggaaaggga tttgccgttg tcgcagatga agtcagaagg cttgcggaac 24361 agagtactca aacagtggga cttatccatc aggttataac gaatataaag gacgaagcag 24421 atgcgatatt ggacaaggta tatagcggaa ccgaggcaac aaaagcagga gaagccattg 24481 tgaaaaaagt aagtgagagt tatgaccgga tgaaccagtc ttttaaggat attgacaatt 24541 atattgacag tgagttgaaa atgattgaaa acactactct tctcttttct caaatacgta 24601 aggaaatgga aagcatagcc ggaatttcgc aggagcatgc ggcagcatcc gaagaaatgg 24661 ctgcttcgat gcaggaccag aaagataaaa ttgagagtat ctttaattct atgaaagaaa 24721 ttcagaaatc aagtgaagag cttgaaatga ttgtaaaaga caagtgattg taaaacacac 24781 ataatatttt ttgttcttat taggacgtga atggcgtaaa ataaatagga gctgctctgg 24841 ttaatcaaat taacgggcag ctcctgtttg tttttatttt taaggttcaa ttccccaata 24901 tagagttcct gatatataca ctgtaatctt gtcccagact acaaaatctg aagaactgtt 24961 gttgaaggag tagtcggaat tttggtcgta catataattc cattctgaat aaggcggagt 25021 tgccagactt aaagcataac tgtttccgat tctgctgatt atttcaacgt actcaccggg 25081 atttagaaca ccggcactgt tagtgaaacc tatttcaacg tagctgtcgg cattaggttt 25141 tgggtttgac atttgaacca cagttcctgt tattttggat gaagtaatgt ttgaccagtc 25201 gcatgtgtaa atctcattga ttacttgatc ctttgtataa taatacctga tttttacctc 25261 agagagcgtt attggcgtat ttccggtatt tatcagcttg attctgggtt gaagctcttt 25321 ggtttcggag gttctgatgt gattgtatgc ctgaagctca atctttgtta acaagtcagt 25381 ttccgtaggc gctggcgatg gaatcggtgt cggcgatgat gtgggcgcag gtgatgttgc 25441 aggtgtaagc gttggtatgg acgtaggtgt ggatgtatat gcaggtattg gtgtggatgc 25501 aggagtggat gtatatgtag gtattggtgt cgatgtaggt gtggatacgg gtgcaggtgt 25561 tgacgtaggc ttgggcgtag attccggtgt aggcgttgat gtaggcttag gtgtggacgc 25621 aggtctaggt gtggatgtag gtgttgatat aggcttgggt gtagatacat gtgtgggtgt 25681 cgatacaggc ttgggtgtag atgcaggtgt aggtgttgat gctggcttgg gtgtggacac 25741 aggtacaggt gtagattcgg gtgtgggagt agatgaatat gcaggtgttg atacaggctt 25801 gggcgtagat acaggtacag gtgtggatgc aattgctact acattggttg gtacaggtgt 25861 ggatgacccc gtgaaagtcg gggtggtttt atcggcagcc ggagtgtgca cgatggcagg 25921 cccggatgta tgcgggattg acggagtttt tggcggtgtg ggaacatgtg ccgtaaaact 25981 tgccggtgtt ggtgaagatt ttggtatatc aacaggttgc gcttctgttt tttccggtac 26041 agcggtataa gccggtgtaa cacttggcac aggttcagcc ggaaccgaaa tcgcaggcat 26101 aattccggag tcttccggag tatcggagat ggcgaatttg ccaatgttta ctttgccaag 26161 aatctcggag acgcttaagt ttcgggcatc ttccaggtta agattgacac cttcttccac 26221 agcttttaca tatatagcat accttcccat ggaaagattt tggtctaaag ctttttgtct 26281 gtcctcttcg gtagacggta taatttcaaa tttgactcct gcatcctttg caacgtcttt 26341 gagggtggat attatttcct gaatgccttt gtcactttcg gaaacattgt tccggccgga 26401 gtttattgat gcggagaaca gaacaatatt gtctgcggaa tttatatatc cgtttttctt 26461 tgaaatatcc agtattttcg ataaagcgtc gtataacggc atgtcttttg gggccgcttc 26521 atcgagaatc ggttttgcgt cattatttaa aggttttgcg tctataacct tttccttttt 26581 atcaattaca agcccaatgc ttggatttat atcaacatct atataagcat attcctggga 26641 aattgaaacg aatctcagac tgaaaagtat tacaagaaaa actgcagcgg cagcggcaaa 26701 cgcagaaaaa ggcataatga tacttttata cctcgtaatg agaccggctg aatacaagtc 26761 ggattcatcg aaaataacat gctggccgcg ttgcatgccg ggtttgagct tcagttccat 26821 aaaatcaagc ccgtcagtca atacgattgc cctgtcactt tccagtttca aaatgattcc 26881 cgtgtaatgt gacatattat tttgtgctcc gttcaatgtt gtcacctcct ggttctgaga 26941 tgtctagaaa gtccttgagt aagttgaagt cgtttccaaa gatcaaagca gcggctatga 27001 tgaatgtacg gtttctctca attgtctttt tatttatctt gagtaatttc aacagttctg 27061 ttttcggtat gtttcgggtt ctctcaagtt tgctgaaaag ttctttgttg tcggcaatta 27121 ctttggcaat ctttatacac agggattttg aatctttgtg ctttggtgcg catttggcca 27181 gatgttcaag gctgattcca aaatcccgaa gcttttgttc atatagctcg atttctctgc 27241 tgatttcata tgtgttttgt aaatcaattt cactttttaa atgtatttgt tcaaaatagc 27301 tgttgttttt atcttcaaaa tatgtaaaag gatatacatg gcaatgtttt ttattgtgac 27361 gagcgtaatc ggtaagtctt ctttttatta ccaaagtcga gaatttaaag aaaaacatgt 27421 tttttccttc atcaaagctg tcaatagctt cattgaaggc ggcaagaccc acgctgaact 27481 catcactgtt ttcaacatca acatatttgc cggtcaaatt ggagactgtt ctgataatat 27541 aaggtgtata gctgttgatg aactcttccc ttaataattt gtctccggcc tttattttat 27601 ttataatatt cacgataccg tcctcgaagg atttatcttt attagttgta ctaactgtat 27661 ctttttttcc cttaggggaa aacaaatcaa tcaagtaatt caccccttga ccacagcatg 27721 tggttttgaa tcatctggta tgactgctgc aaagaagaga actgtgtata ttagagtata 27781 tagtgattat agcacactaa actgctataa aaaaggggct tgaaagcaca atcttttctt 27841 attactagtt atttcgtaaa gggaacattt tttcggggga taccaataaa aaatcttaaa 27901 ctaataaaaa aataaaaaag gatgaaattt agtcaatatt accctatcaa ataacccatt 27961 caattcgcat ttattttaag ggagaaaatt aactgtttga agattatata tattttgaag 28021 attatatata tattctttta tttctgattt ttaattctaa tttgtataaa catgacaaaa 28081 taaatatgat ataatgattg taaaggattg gttggcataa cggagacttt aaggatgtta 28141 ttggtttggt aaatgttttt gggtaacgat atttattttt atttataatt tttatttata 28201 aattttatat taaatttaaa aaggaggaaa aaaagtgaag aacgtaaaaa aagagtaggt 28261 gtggttttgc tgattcttgc agtgttgggg gtttatatgt tggcaatgcc ggcaaacact 28321 gtgtcagcgg caggtgtgcc ttttaacaca aaatacccct atggtcctac ttctattgcc 28381 gataatcagt cggaagtaac tgcaatgctc aaagcagaat gggaagactg gaagagcaag 28441 agaattacct cgaacggtgc aggaggatac aagagagtac agcgtgatgc ttccaccaat 28501 tatgatacgg tatccgaagg tatgggatac ggacttcttt tggcggtttg ctttaacgaa 28561 caggctttgt ttgacgattt ataccgttac gtaaaatctc atttcaatgg aaacggactt 28621 atgcactggc acattgatgc caacaacaat gttacaagtc atgacggcgg cgacggtgcg 28681 gcaaccgatg ctgatgagga tattgcactt gcgctcatat ttgcggacaa gttatggggt 28741 tcttccggtg caataaacta cgggcaggaa gcaaggacat tgataaacaa tctttacaac 28801 cattgtgtag agcatggatc ctatgtatta aagcccggtg acagatgggg aggttcatca 28861 gtaacaaacc cgtcatattt tgcgcctgca tggtacaaag tgtatgctca atatacagga 28921 gacacaagat ggaatcaagt ggcggacaag tgttaccaaa ttgttgaaga agttaagaaa 28981 tacaacaacg gaaccggcct tgttcctgac tggtgtactg caagcggaac tccggcaagc 29041 ggtcagagtt acgactacaa atatgatgct acacgttacg gctggagaac tgccgtggac 29101 tattcatggt ttggtgacca gagagcaaag gcaaactgcg atatgctgac caaattcttt 29161 gccagagacg gggcaaaagg aatcgttgac ggatacacaa ttcaaggttc aaaaattagc 29221 aacaatcaca acgcatcatt tataggacct gttgcggcag caagtatgac aggttacgat 29281 ttgaactttg caaaggaact ttatagggag actgttgctg taaaggacag tgaatattac 29341 ggatattacg gaaacagctt gagactgctc actttgttgt acataacagg aaacttcccg 29401 aatcctttga gtgacctttc cggccaaccg acaccaccgt cgaatccgac accttcattg 29461 cctcctcagg ttgtttacgg tgatgtaaat ggcgacggta atgttaactc cactgatttg 29521 actatgttaa aaagatatct gctgaagagt gttaccaata taaacagaga ggctgcagac 29581 gttaatcgtg acggtgcgat taactcctct gacatgacta tattaaagag atatctgata 29641 aagagcatac cccacctacc ttattagtgt aatgggtttt tgacagattt acggaaagag 29701 ttactgcaaa ctacctgaat aggtgggcag taactctttt tgttttcaag cctgttaata 29761 agaaattgtt ttgtaaaggg tagcttgtaa tatttgtatt ttggaggtct cttatgaaaa 29821 aaataccgtt acttatgctg ctgtcagcaa taatattttt atctttacat cccacactgt 29881 cgtatgcaca ggacgactct cttccgacaa aaaggatagt aggctacttt gctgaatgga 29941 atatatatct tgaaaacaat tattatgaag tttcagatat tccatgggat atggtaacgc 30001 atataaatta tgcctttgcc aaaattgaaa atggaaggat agcaattatt gataaatggg 30061 ctgcgatcca aaagcctttt ggcgacgata cctgggatac accgataaga ggccattttg 30121 gacaactgat aaagtacaaa gaacagtatc cgcatgtaaa aactctgatt tcagtgggag 30181 gctggaccga atccaaatat ttttcggatg ttgcattaac ggaagaatca agaaatacat 30241 ttgcggacag ttgtgttgag ttcattcgta cataccggtt tgatggagtg gatattgact 30301 gggaatatcc tgtgagcggc ggaatgccgg aaaatattag aaggccggag gacaagcaaa 30361 actttactct tttgttaaaa tgtcttagag aaaaacttga tgccgcaggt gctgaagacg 30421 gaaagcacta ccttcttaca atagccgcac cggcgggaag ctttaacata aaaaacaccg 30481 agcctgagat ttatcatcaa tacctggatt ttatcaatat tatgacttat gattacagtg 30541 gctcatggga aaatgtggcg aatcatttgg ctccattgta tatgaatcca aacgacccgt 30601 cctatcctga aagaaaagag aaattcaatg tggattggac ggtaaaggaa tacttaagac 30661 ttggtgttcc cgcggagaaa ataaatgtgg gagtaccgta ttacgcagca ggatggcagg 30721 aagttaacgg cggtataaac ggacttttcg gaacgtcatc aaaaccgctc agcagtactc 30781 agttccacta tataaatagt ttgcttaagt caccggactt aggttttaca agatactggg 30841 acgagtatgc aatggttccc tatctgtgga atcctgaaag tgcaacgttc tacagctatg 30901 aagatgaaat ttcccttaaa aataaatgtg attatgtcat tgaaaacaat cttggaggaa 30961 taatgatttg ggaattgagc ggggattacc cggcggaagg aggaactact ttgacatctg 31021 ttatatacga cagttttaca tcattcaaag atgaaattta cggtgattta aacggtgacg 31081 gaaaagttaa ttcaagcgat cttgcaattt taaaaagata tatgctgagg gccataagtg 31141 attttccgat tccggaaggc aggaaacttg ctgatttgaa cagggacggc aatgttaatt 31201 ccactgatta ttcgattctt aaaaggtata tactgaaagc tattgacaat atacctgttg 31261 atgattgaca gtggattttg atgaatgtat ctttccttta gcggcaaaat gagttgtagc 31321 agcatggaac gcaataggtt gatacctttg ttgtacttga gtatttgccg attagatagt 31381 ataatagtag tattaatctg gcacaaattt tttaaggagg taggagttgt atatagggca 31441 tatgttgctg tatttaaaat gccctataat tacacaactt tgctatgaag tggtattata 31501 aatcaaaggt aaaaagacag gttataaaaa ctttgataac tcttccggtt gttttggtat 31561 tgacttcttt ggtggtttat acgtttttga caaacaacag gtcaggatca agagatgctg 31621 acggaacttt cccggacagt gtcaaaagtc cttccattgc cataaatact ccttcgcccg 31681 ggactgatgc aactgcatcg gcaggacttg tacctgacaa tacatttttg acggagcaca 31741 caaatgcgcc gactccaaca gatgacatta cgcctacacc tacacctact cttgaaccaa 31801 cgcctgaacc aactgctaca ccgacatcca caccaacatt tacgccgacg tcaaaaccaa 31861 cgcccaagcc gactgccaca ccgacgcgaa aaccgacgcc gacacctacg cacacaccaa 31921 caccgaaacc tgcacaaaag acacctgaga aaaaaggtcc gattattaca gtgcagtata 31981 aaaacgggga ttccacatct tcggttactg caatttatcc tatatttaaa ataacaaaca 32041 atggagacac aagtgtaaag ctttcggata taattatcag atactactac accaaagaag 32101 gaaacgagaa tgaaactttc tggtgtaatg agtttacaag ggacggttcc caagtgtacg 32161 gtacttttgt aaagatgagc aagccgaagg agaatgccga ccactatctt gagattggtt 32221 tctacgataa ggcaggttcg ctcaagccgg gagaaagtgt ggaacttaaa gtgggttttg 32281 ctaaaaacgg atggacaaaa tacaaccagt ttaatgacta ttcttacaac agggtgaaca 32341 acagatttat aaactgggat catattacgg tttatttgtc cggaaagctg gtatacggaa 32401 aggaaccgta agacatcctc ttgtacagga caaggaaaac ctgcatttcg aaagaatttt 32461 atatggagct ttatatttca aatgtggggg atttgccccc acatttgaaa cagaaaaaag 32521 aatagttttc gttaaaatga ctaaaacagc gatttaaaga agttggctat gtttcttaaa 32581 atcatggcaa aaaatccaag acgttccgct tcttccgcag tggacatggt tgaggttgca 32641 attgtttttc cgtcaagctg aacctcaacg gttcctgcag gaatatccaa agataccggt 32701 gcattaagga attctgcttt ttttgatgtc acaatctgaa ggtcgttttc cctaccgaca 32761 ggtattactg tggaaatgtc actgtccaat ttcaatgaaa ctgaaagttt tttaccgttc 32821 ttaacctcta tggaatcaac tatttcaccg gcatttttca ctgttacctg tttaaagttt 32881 ttaaaaccat agtttaaaag ttcctggatt gctttcgagc gttctttttc actgctggtt 32941 ttcagcacga cacctatcat tctttgtcca ttttgctggg ctgttccaac tatgcaatat 33001 cctgcttctt ccgtccaacc ggtttttaag ccgtcagccc cgggaaaaac tcctagaaga 33061 ggattgcggt taaactgcct tatattgttg taggtatact ctgttgtgga ttccagctca 33121 agaattttgg gataattctg tattaagtaa cgtgccaatg tggaaatatc tcttgcgctc 33181 ataacatggc cttccgccgg caaaccgttg gagtttgcaa agtttgtgtt tgtaagccca 33241 agctcctttg cacgagtgtt cataacctga acaaaggctt cttcacttcc atatagatgt 33301 tctgcaaggg caacacatcc gtcattggct gagacaacgg atataccggt cattatctcg 33361 ccaaatttag ctttgtctcc tacaagcagg aacattttgg agccttccat tctccaggcc 33421 ttttccgaga ttattacttc atcgtcccat tttaccaatc ctttttccaa agcctcgaag 33481 ccgagtaaga gagtcatgat tttggttatg ctggcaggag gcattggaac gtcagcattt 33541 ttttcataca gcacctgtcc tgtggaggct tcaattaaaa ttgccgattg ggcggaagat 33601 tcaaactggg caaaagcttt tacctgaaac atcattacaa aaaaagtgat tacggcaaga 33661 accgagacgg aacgaaaacc ttttaaatta tacatattgc ataacactcc tgtataatgg 33721 aatataaata catatgagaa taacactata caatattatg ttaacattga tttgctatat 33781 cggacaaatg taaaatttag ctatacagga gtattttata gggaaaagga atttacctaa 33841 gctgctttaa atttgctttg tatcagtttt acaaatattt ttacgagatt gggatcaaat 33901 tgttttccgc atccggagat aatttcattg agtgcatcct caggacttag agtttttctg 33961 tatactcttc ttattatcat tgcggaatag gaatctgcca attgcagaat tcttgcttca 34021 aaaggtatgc tttctcctgc gagtccgtga ggatatcctg tgccgtccca gttttcgtga 34081 tggtatgcta tgcaatttat aatttcgaca gggagagata aattattaat tatgttaagt 34141 ccataattta catgtccctt gataagctca tattcttcgg gagttaaagt agtgcttttt 34201 cttattatgt cgctggatat aagaatttta cctatgtcat ggagccatcc ggcggcataa 34261 atgcgttcaa cctgttcatc cggaagaccg gcttcttttg caagcgcagc agcgtactga 34321 gcagtgtacc tggaatgaac gtaagtgtac atatcctttt ccgccaggac atttaaaagt 34381 tcaaatcctt cctttggaag gagaggtttt ttgttatttg taaagatgtc cagcctatgg 34441 tttttgcact tgttataata catatttata tctgctttat acaaaagctt ttctatgtca 34501 ttttctgtgt cggaaggcga cgaattggcc tgccccacgg aaaaagacag atttatcgga 34561 tccagttcct cgtcaattac gaacttcttc tctcttattg cttttgaaag atgttctccc 34621 aaatttttta ctctttcgtt ttttccatca ttttttacca caataataaa ctcgtcgcca 34681 ccaagccttc cgattattct ttcaagacct tcggtttctt ctttgagaaa ctccgaaact 34741 tttatgagca ctttatttcc cgccacgtga ccgaaagtgt cgttaatttg cttaaagcgg 34801 tccatatcgg taatcagaat tgaaatatta ccgttttgga tcattttttt ggcagtttca 34861 attgtgtggg caaaggttgc cacacctgta agtgaatctg taatactcat ctttttgtat 34921 ttgttgcgtt caataataac ctttccgaat aactggtata tgaggacaag tgtaattgta 34981 aagcaaattt ggccgttggc tgttccaatt actttgccaa tgggatacaa ccctgctttg 35041 gcttcgggca taagcatgaa tattctaagt gcaggataca gcccggcaat gagaggaaac 35101 agtatatttt ccagaagaag cacatagcaa atggtaagaa cgctccattt gttgactacg 35161 gtatagtacg gataaggcaa agaatgcgaa tccacaacaa aaataaacag cacatatgac 35221 aatactgcaa gcaagtgttt tagtgccttg tgcctgatga aaaactttgc cgtaatcatc 35281 attgccgcaa aggcactcat atacaggaat gttggaaaaa aatgacctgt ttcatagatt 35341 atgtatatta ccaatatacc aaccaaaaat acaaatgaaa cattgaaaaa atgtttatta 35401 aaaaaggcta tagttttgct tctcttttca tcatattgca ttttctaaaa ctccccgtta 35461 aacaatttaa aatttaaagg aaaccaataa aaaattggca aacaattata tctttataat 35521 tttatagtta ttctaaatat aagtttatac aaaaagattc aaactatcaa tataaaaaat 35581 atgttttcct gcgctgataa agacttaaaa gcagttaaac cgaaaaacag cctcttttgt 35641 gtttagaggc tgttttttgt ggcttttgga actctaatta atttaattta tgatgtttcc 35701 atagatatca tatttaaccg gaaattcgct aatactgcga aggacatatc tttttagcaa 35761 taccatgtca ctggaattga ttgcaccgtc gccgttggtg tctgccgccg gtatgcgaat 35821 cctttcattt tcctggtaag gaaggacact tatactgcgc aaaagatacc ttttcatgta 35881 tgtaatgtct actgagttta ttgaaccgtc aacgtttaag tctccgacat cacaccatat 35941 taaggaaggc gttgcggtag gagacggggg tgtagtggct ggaggagtgg gtataacgat 36001 attgccgtag tatttttcaa tagcagccag agcgcccacg aaagcagcat tatagtcaat 36061 agccacttcc gtaaactgga actgattgac atcatcgata aagttgtcag acatattcgg 36121 accgcccacc aaagcaccta aaagaaggtt tttggcaggt tttgcattgt caccgttggc 36181 gtaagtgtag ccgttggctg ccctgtggtg aggacatttt gggtagtttg atccataacc 36241 tataacatag gacatgttga tgggattgct gccaagtatg tagtctattt gagattttgc 36301 aaaggatttt aatgcttcat ttttggtaag ctcgtagtat ctcatggcga taaaggcctc 36361 ggcggccgca tatcttaata ctccccagct gtcaagatac ttaaggcctc cgggagttgt 36421 attaagggaa ttcatccagt aatcgagatt gtaattcatt gcgtcaatgt acttttgttc 36481 acctgttatc tctgcaagtt tgcagaagac agccatgtac atgtcatccc agcacattgt 36541 ccatttgttg ttgaaaggac tctctcccca aagggtttta tttgaaagat agctgtcaat 36601 ttccttcagg taagtcgggt ctttttccac tacatagagc caggtggctg caaaggaaag 36661 atcgtcccag taggagtggg agatgtaaaa agcattctcg gcatagtagc ccaaattggt 36721 ttttgccatt gtataaagtt cttttgcagc ttttaaacat ttgttggcat agttttggtc 36781 tatatccttg tagtttaggt acattatcgt aagagcggcg gatgtcaaac cacatacatc 36841 agaagccgca tttgaggcat tggcaacata gggtacgggt ctcggacccg gctggacttc 36901 cggcgcaccc cagtatgtat ggtctgcctg accgtctcct acttgatagt agaaggtatt 36961 ggagtccgga tgacatttta aaagatagtc ggtgaaatat ttgagagtac tgagcatttt 37021 ggaggtgttt cctgttgcgt caaacactcc tttgtattca taaagtgacc aacccagtac 37081 cgctgccgca taagcctggg gcaaaccgaa tttgacatgg tctccggcat catgatatcc 37141 tccggtcaga tccaggccta tttcacttcc gtcagtcgtg tgacacggtc ctctccaact 37201 gaagacattg tcaactgctg catccggacc gcatttgttg gcgtcgtaaa ataaaattga 37261 gtattttaat gcggtggcat aatcatgact tgcagctgcc gatgaaaatg acattgaaaa 37321 cagagtcgtg actaagaacg tcaaagtaat taacaataca gctatttttc tcatgctttt 37381 acccctttca taaaatttaa ttttatcgtt atcataaaaa attatagacg ttatattgct 37441 tgccgggata tagtgctggg cattcgttgg tgcaaaatgt tcggagtaag gtggatattg 37501 atttgcatat tgatctattg cattgaaatg attagttatc cgtaaatatt aattaatcat 37561 atcataaatt aattatatca taattgtttt gacgaatgaa ggtttttgga taaattatca 37621 agtaaaggaa cgctaaaaat tttggcgtaa aatatcaaaa tgaccacttg aattaatatg 37681 gtaaagtaga tataatattt tggtaaacat gccttcagca aggttagatt agctgtttcc 37741 gtataaatta accgtatggt aaaacggcag tcagaaaaat aagtcataag attccgttat 37801 gaaaatatac ttcggtagtt aataataaga gatatgaggt aagagataca agataagaga 37861 tataaggtac gaatgtataa gatggtgctt ttaggcacac taaataaaaa acaaataaac 37921 gaaaatttta aggaggacga aagatgaagt tcggtttttt tgatgatgca aacaaagagt 37981 acgttattac cgtgcccagg acaccgtatc cgtggataaa ctacctgggt acagagaatt 38041 tcttctcact catttcgaat accgcaggcg gatattgctt ttacagggat gcaaggctta 38101 gacgtataac aagatacaga tacaacaatg ttcctattga catgggagga cgttatttct 38161 acatatatga caacggtgat ttctggtcgc cgggatggtc tccggtaaaa agggagcttg 38221 aaagctatga atgcagacat ggactgggat atacaaaaat tgccggtaaa agaaacggaa 38281 taaaagcgga ggtcactttc ttcgttccgt taaactacaa tggtgaagtc caaaagctta 38341 tattgaagaa tgaaggacag gacaaaaaga aaataactct cttctctttt attgagttct 38401 gcttgtggaa tgcttatgat gatatgacca acttccagag aaacttcagc accggtgaag 38461 ttgagattga aggctcggtt atctatcaca agacagagta cagagagcgc agaaaccatt 38521 acgcattcta ttctgtaaat gcaaaaatca gcggatttga cagtgacaga gacagcttca 38581 taggacttta caacggtttt gacgctcctc aggctgtagt gaacggcaag tcaaacaatt 38641 ccgttgcgga cggatgggca ccgattgcgt cccacagcat tgaaattgaa ttgaatcccg 38701 gggagcaaaa ggaatatgta tttattatag gttatgtgga gaacaaagat gaagaaaaat 38761 gggagtcaaa aggtgtcatc aacaagaaaa aagcttatga aatgatagag cagttcaaca 38821 ctgttgaaaa ggttgacaaa gcatttgaag aactcaagag ctattggaat gctcttcttt 38881 caaaatactt tcttgaaagc cacgatgaaa aactcaaccg tatggttaat atatggaatc 38941 agtaccagtg tatggttaca ttcaacatgt caagaagcgc ttcatacttt gaatccggta 39001 tcggaagagg tatgggtttc agagattcaa accaggactt gctgggattt gtacaccaga 39061 tacccgaaag agcaagagaa aggcttcttg acctggctgc aactcagctt gaagatggcg 39121 gtgcgtacca tcagtatcag cctcttacca aaaaaggtaa caatgaaatc ggaagcaact 39181 tcaacgatga cccgttgtgg ctgattcttg caactgctgc atatattaag gaaaccggtg 39241 attattcaat actgaaggag caagttccgt tcaacaatga tccgtccaaa gccgacacca 39301 tgtttgaaca tttgacccgt tccttctacc atgtggtaaa caaccttgga cctcacggat 39361 tgccgcttat aggtagggcg gactggaatg actgccttaa cttaaactgc ttctccaccg 39421 ttccggatga gtcgttccag accacaacaa gcaaagacgg aaaagtggca gagtcagtta 39481 tgattgccgg aatgtttgtg ttcatcggaa aagactatgt gaagctttgc gaatacatgg 39541 gccttgaaga ggaagccagg aaagctcagc agcatattga cgcaatgaag gaagcaattc 39601 tcaaatacgg ttatgacggt gagtggttct taagagctta cgacgacttt ggaagaaaag 39661 tcggaagcaa agaaaacgaa gagggtaaga ttttcattga gtctcaggga ttctgtgtaa 39721 tggctgaaat cgggcttgaa gacggcaagg ctttgaaggc tctggattct gtcaagaaat 39781 atcttgacac tccatatggt cttgtacttc aaaatcccgc gtttacaaga tactatattg 39841 agtacggaga aatttcaaca tatccaccgg gatacaaaga aaatgccggt atattctgcc 39901 acaacaatgc atggataatc tgtgctgaaa cggttgtcgg aagaggagac atggcgtttg 39961 attactatag aaaaatagca cctgcttata ttgaagatgt aagtgacatc cacaagcttg 40021 agccttatgt ttatgcacag atggttgccg gaaaagacgc aaaacgccat ggagaagcta 40081 agaactcatg gctgaccggt actgcggcgt ggaactttgt ggcgatttca cagtggatac 40141 tgggtgtaaa acctgactat gacggattga agattgatcc atgcataccc aaggcatggg 40201 acggatacaa agttaccaga tatttcagag gctcaactta tgaaatcact gtgaagaatc 40261 cgaaccatgt atcaaaaggt gtggctaaaa ttactgttga cggcaatgaa atcagcggaa 40321 atattcttcc ggtgttcaat gacggaaaga ctcacaaagt tgaagtaatt atgggataat 40381 aaagcaaggt atgacaaaaa gaagttatcc gggtttttcg gataacttct tttttaaaat 40441 agcggcggtt aaaactctat tcaatcctgc gttctttatt gacaaaaatg atataccgca 40501 taatggcaaa tgattgcatg tttactgcaa tttacgcaaa atacaaatga ttatatcgta 40561 gaatcatcat catagtgctt tctgaagcga aaggctgtaa taattgatat attgagaaat 40621 tgttgtattg ggagagatga aaaatgctaa agatatgtgt tttggatgcc aaaactctgg 40681 gagatgacgt ggatctgacg gtgtttgata aatttggtcc tgtacaggtt tatgctgaaa 40741 caaagccgga ggaagtggtt gaaaggatta aggatgtcga tgtcgttatt accaacaaag 40801 ttgtgctgaa taaagaaaac cttgaaaatg cctcaaaact caaactgatt tgtgtggctg 40861 cgacaggaac caataacata gatcttgaat atgcggcaca aaagcaaatt gccgtaacca 40921 atgtggcggg atactcaact atgagtgttg tacagcatac ttttgcgatg ctgttttatt 40981 tgatggagaa tttgccttat tatgacaggt atgtaaagtc gggagaatat gcaaagagca 41041 atatttttac tcatcatgaa aggccttatc atgaattggc cggtaaaaca tggggtatca 41101 tagggcttgg aaccattgga agagccgtgg ccaatgcggc ggaggctttt ggatgcaggg 41161 tggtttacta ctcaacttcg ggaaaaaaca ataatactca gtatgaaaga gctgaactgg 41221 agaaattgtt gaaagagtct gacattgtgt ccattcatgc gccgctcaac aataacacaa 41281 ggggcttgat tgattatgag cgtttgcgta tgatgaagaa aagtgccata atattaaatc 41341 ttggacgcgg aggcattatc agggaggagg atttggcaag ggcgctggat gaagaattga 41401 taagcggagc tgctcttgac gttttggaaa aagagcctgt aaattgtgac aatcctttac 41461 ttggtgtaaa aaacagtgac aggcttttca taactcctca tattgcgtgg gccagcgttg 41521 aagcaagaaa aagacttgtt gatgaaatag cattgaatat tgaggctttt attgagggaa 41581 aagagcgcaa cagagtatgc tgattgttgt ttgtttttgg aaaaatcgtg attttagaaa 41641 gaatgtgatt ttaacaagaa agaagcagct tcgggggtga agctgcttct ttagactttg 41701 ctgtacttac tcttctctgt agccgtagtt tccgttaaag aacaagagca ggaatacgag 41761 aatgaagaac aatatttcgc tgttgtctcc gaaaaatcca aagcctcttc cttctgacat 41821 tataaatcct cctttctgat actctgtgga ttataaattt ggggttttat gccaaattta 41881 taatctttgc agaacaaagc aaaaagtaat gacaaataac ttggagaggg tcaatactcc 41941 tcgtttacgg gtcaatatat aatattcatg cttttaacaa tttgttactg ggtgaaattt 42001 gagagcaagc ttttgattca gtccatgttt tttaatcaaa tacatgtttt ttatttaaaa 42061 aagcgagcag tatggtataa tatttcaagt gtttttgttg tcggtttttc tataaattga 42121 ggcaaaatat atgtaattga acttgaagac ggaggttttg acatgatgtt gctggcagat 42181 gactggaaag attatgagct tatagatacg ggaaacggag aaaaactgga aagatgggga 42241 aaatatatac taagaagacc cgatccgcag attatatggc ctatcaggaa tgagaacggt 42301 ctttggaaaa aggcggatgc ccattaccac agaagccgga gcggaggcgg cagttgggaa 42361 tttaaaagaa agcttcctga aaggtggaca atatcctatc atgatctgtc attttatatt 42421 gaacccacag gttttaaaca tacaggtctt tttccggaac aggccgtgaa ctggaaatgg 42481 atgattgaca aaatacgttc tgcatccaga aatataaacg tgctgaacct ttttgcctat 42541 accggaggtg cgactgttgc ctgtgcctat gccaatgctt cggtttgcca tgttgacgcc 42601 gcaaaaggga tggtgcagcg ggcaaaggaa aaccttgctt tatcagggct ggcggacagg 42661 agtgtaaggt ttattgtcga tgatgtaata aaatttgtgc aaagagaaaa gcggcgcgga 42721 cgtcagtacg atgccgtaat tatggatcct ccttcatatg gaagaggacc ccggggggaa 42781 gtgtggaaga tagaggatga gctttatggg tttgttgaac aatgcattga cgttttgtct 42841 ccaaaacctt tgttttttct cataaattca tatactgcag gtttttcacc tacagttctt 42901 gccaatatac ttaaaatgac agtggtgaaa agatttggag gtgttgttac ctgcggtgaa 42961 gtggggatac ctgtttcatc ttccggtatt gttcttccat gcggcattta tgcccgttgg 43021 gaggcacaga aaaaatgagc tcttgcggaa acaacggcat tgatataatt tttgaggaca 43081 atcatctgct ggtggtaaaa aaaccggtta atattccaac ccagaaagat aagtccaatg 43141 acagcgacat gcttactctt ctcaaagagg acataaagaa aagatacaac aagcccggaa 43201 atgtctatct cgggcttgtt cacaggcttg atcgcccggt ggggggagta atggtttttg 43261 ccaaaacctc gaaagccgca tcaagacttt cagaccaggt acgcaccaga caatttaaaa 43321 aggtatattt ggcagttgtt cacggaattt tggacaagct tgaaggaaga cttgagaatt 43381 atctgttaaa agacaccagg aacaatacgg taagcgtggt caaagaagac acgccgggag 43441 gcaagctggc ggttttggat tacaaggtag aggggattta taacggtttc agtttggtaa 43501 aagtcagttt gcacacagga cgtcctcacc agatcagggt ccaactggcc aatataggtc 43561 atccgttgta cggcgatcag aagtacggcc atggcgtgaa caaacccgga cagcagatag 43621 ctttatggtc aagtgaaatt gcctttgttc atcccgtttt aaaacaggaa atgatttttt 43681 catgtgaacc tcctgaagtt gaaccgtgga cttggtttaa cagagtatag cagaagaaca 43741 ttaacatgac aatttgtttt agttgtaaat atttatttta aaacagagag ataataaaat 43801 aaaaaaggag gactgtcatg aaacaattaa ccgccagtga gattttgttt gtaagcaaac 43861 ttcttcagct cgaatccgcg gatctctctg ttttaaaagc gactttgccg tttgtttcgg 43921 acaaggaact taaagaattg atcaagacat ccgtaaaaaa ttctgaggcg agaatcaatg 43981 ggcttaggca gtttatcagc gacaacgatg ttatggttgc cggaggtgtg cagtaacaat 44041 ggcatctata cttgaaaaca tattcggcca aaatatgagc aaacctaccg atgagacaat 44101 cgcctacaac ctcatggccg gagcggcggc tgctgccacg gcttatctta ctgcaactct 44161 tgacaccgtc acaccggagc tcaggaggct tttgaatgac tatacaaacc agattatatt 44221 gcagcacggg acgttgacga aacttgcggt ggaaaaagga tggtttttac cctatgaaac 44281 tccgatgaag cagcttcaaa tttcgcttgc caatacccag tccataattg aaaacaatgc 44341 tcaataaata tataaaattt atataaaaat ttatataaaa atttgtataa acccattaca 44401 ggaaaagtcc gatatattag gcaatataag caaagtgttc cggcttgtat tgcctttgtt 44461 ttttctttgg ctttttacca aatacgtacc aatttttttg aaccgattga ctgttatgtg 44521 tatcatttat catatcaatg gatagatatt ataatatatt tgatatattt taaaatatat 44581 attcttaaag aaaaattttt tatataccga caattaaact aacaataaac taaattatta 44641 cgggaggatg ccatgaaaaa aataaaagtt ctttttgcgt cttcggaagt tgatcctttt 44701 gcaaaaacag gcgggcttgc agatgtagcg tcttcactgc cgaaggcttt gtgcaagctt 44761 ggacatgatg tgagggtggt aatgcccaaa tacaaggaca taccttttca gtacgttgag 44821 aaaatgcaaa aggttggaga aataggtgtc tatgtatcct ggaggaggca atactgcggg 44881 attttaaaat tggaaatgga caatattaca tattacttta ttgataatga gtattatttc 44941 aaaagagacg gttattacgg gtattatgac gaagctgagc gttttgcatt cttttccaaa 45001 gcagtgctgg agatactgcc tgtgattggt ttcaagccgg atataattca ctgcaatgac 45061 tggcagaccg gggttgtgag tgctttcctt aatgcatggt acaaaggctt ggatttctac 45121 aaggacataa agacggtatt tacaatccac aacctcaaat atcagggaat atttccaaaa 45181 gaagtttttg gcgaagtctt aggacttccc tgggattatt tccatgccga cggaatagag 45241 ttttatgaca aggtgaatta ccttaaagcg ggtattgttt actcggatat aataacaacg 45301 gtaagcaaaa cctatgccga ggagataaag accgatttct tcggtgaaaa cttaaacaat 45361 gtgctgagaa aaagatcgaa cgacctctat ggtatcttga acggcataga catggaggaa 45421 aatgacccgg ccgttgataa cagaatcttt gccaactact cggttgacaa ccttgaaggg 45481 aaacttacga acaagcagat gcttcaaaag agtctggggc ttcaggaaag aattgatatt 45541 cctctgatag ggatcatatc caggctggtt gcccaaaaag ggtttgattt gattgactat 45601 gtaatggatg aaattttaaa aatggatatt cagtttgtgc tgcttggggc aggggaatat 45661 aggtatgaac aaatgttcag gtattatcag gaaaagtatc cgggtaaaat ttctgtaaac 45721 ctgaaatatg atgctgtttt ggctcaaaga atatatgcag gtgcggatat gtttttgatg 45781 ccgtcccttt ttgagccttg cggactaagc caaatgttca gcctaagata cggtacaatc 45841 cccatagtcc gggagaccgg aggacttaag gataccataa ctccttacaa tgacatcacc 45901 catgaaggaa atggctttac tttttcaaga tacaatgccc atgacatgct ttatgccatc 45961 aaagaggccg ttcattatta ctatcacagg tcaacatgga cgtatctgat gaaaaagggc 46021 atgaccaccg atttcagttg ggagaagtct gcaaaggaat atctcgaact gtatgaaaaa 46081 ttggctggaa attaaatatt cagaaaggtt aattgctaaa agagattaat tccacggaaa 46141 acttaaaaac gaaatcggac aaacaataaa aacagggcta ttgaagtttt ttcaatagcc 46201 ctgaaattat gttcaaggat tttaacactg taaaaataat tcagtaaaaa agccaatgcg 46261 atattcggtg ttacaatata ctatcggtta ttaaaaatgg gttgttaatg tattattgac 46321 tattgaagaa tggcttcaat tttattgagt atttcatcag aaagatttat tccggatgct 46381 ttaacatttt cttcgacttg ttcgggcttg ctggctccaa ttaatgcact tgtaacattg 46441 ggctgtctca aaacccatgc aatggccagc tgtgaaaggg tgatacccat ttcatcagcc 46501 acagccttta gtttttccac cttcaacagt ttgtcttctt taaggaattg gcctatatac 46561 atgttggagt tgggatcggc tgcgcggctg tcccgtggaa tgttgccacc gggtttgtac 46621 ttgccggtga gtacaccctg ggcaagagga gagaaaacaa tctgggaaat tccgttcttt 46681 tctccgaaag gaatgatttc tttttctata tatctgtgga acatattgta ttggggctgg 46741 tttacgacta tccgatccag aagataacga tcggcaatgt atagggcctg ggccatctgt 46801 gccgccgtcc actcgcttac tccgacgtaa agtattttgc cctggcgcaa aaggtcgtct 46861 atggttctca aggtttcttc aagcggagtt tcagggtcgt accggtggca atagaaaatg 46921 tctatatagt caacgttaag tcttttcaaa cttgcatgaa cctgctcaaa aacatgtttc 46981 cttgacagac ctttgtcgtt gggaccggta cccatcggcc agaatgcctt ggttgcaagt 47041 atataagatt cgcggggata tttttttaaa gcttctccca caataacttc agctctgccg 47101 ttggcgtata cattggcggt gtcaaaataa ttgattccga gggaataagc tgtgtctatg 47161 actttgactg ccgtttcctt gtcggtggaa ttgccgtatg tcaaccagct tcccaaactg 47221 atttcactga tataaagtcc tgtgcgtccc atttttctgt atttcatctt ttgtgcctcc 47281 catcaatttt atatcactta atagtatacc attctgtttg tatatttaac acatatttgt 47341 tgccgtgaac atcggcaagg tatatactta aaataatgaa aaagataata aaaaggataa 47401 acgaaaatga aaagataagt agagaaataa gtgaaaaaaa ttagagaaga taagtgaaag 47461 cttggatgat ggagggatta tgttgattaa tgttaatttc aatgaattat tgcttgagtt 47521 ggattcatta agtgtataca ggaatttgct taatgacagt gtaataaaaa aattatatga 47581 acttggggac ctgatttaca aaaaagagcc cgggacggac gaatttataa aaaaatataa 47641 tgaattcttc tttgagttga catcaggttc aatacagtca ttgaaggagc atataataga 47701 gctgatactt tttgatgaga atccttactc aagacagtca gaaaaattac cttttgagaa 47761 tattgataaa gtattgattg acgcagcctc aaaagacttg gatagactcc atgtaatatc 47821 agctcttaca tcccggaagt ttaaagatta tgctttagag aacatctgca aatccgagag 47881 cgaaaaaagg tttatagaca gccttccggc atgggaattt gacggcagaa gcaatcaggg 47941 aaagagaaaa ttgtcccaaa actgccaaaa gatgattgat gttctcgtct caagcaacaa 48001 atggggagaa tgtgtcaaga acctttccga tttttatttt accaacggtt cggggatttt 48061 tgcccgctat catgcttttg tttgggaacc gtcagaaaaa ccttctctca gaggggttga 48121 attccccgat ccgattcgct tgtccgattt tatcggatat gaacagcagc gccttgaagt 48181 aatagaaaac acagaaaagt ttgtcagggg attgccggca aacaatgttt tgctttatgg 48241 agacaggggt acaggaaaat cttcaactgt aaaagccatt gcaaatgaat acagggaaca 48301 gggacttaga atcattgaga taccgagaaa atatcttgtg gattttcctg cggtgttaaa 48361 actgattaag ggaagaagct gtaaatttat tatttttatt gacgatctgg cttttgagga 48421 cagtgaagaa agttacacag ttctaaagtc cgtacttgaa ggaggagtgg aaaacagacc 48481 ggacaatgtg ttaatctatg ctacttccaa caggcggcat cttataaagg agaaattcag 48541 tgaccgggca ggctttaaat cggacgatcc cgatgatgaa atcagggcac aggacacaat 48601 gcaggaaaag ctgtctcttt cagaaaggtt tggaattacc gttgtttttt catcaccgga 48661 caaaaaacag tttttacaga ttgttgaagg ccttgtggct aaaagaggga ttaacattga 48721 taaagacacg ctccaaagag aagctatgaa gtgggagctt atgtacaacg gacgctctgc 48781 aaggactgca aggcaatttg ttgactggct ggaaggcagt atgaaattga aaaagtaatc 48841 tcaaacaacc atgatattca ttattttttt aagtgaaata tggcaaaaaa gatatgttca 48901 aatattgtac aattattacc taaaaggaac ttgataatgg gatgatttta atttaaaata 48961 ataggagact ttgataaatt cataacaatg attcacaaaa acatttaaat attcagagat 49021 agaaggagaa gataagttat gagtaagata aaaatgaaag ttccgttggt cgagatggac 49081 ggagatgaaa tgacccgaat catatggaga ttgataaagg aaaatctctt ggagccatac 49141 atagagctca atacagaata ttacgatttg gggcttgaaa acagggacaa gaccgaggac 49201 caggttacca ttgacgctgc cagggctatt cagaaatatg gtgttggagt aaagtgcgcg 49261 actattactc ccaatgctca gagggttgag gaatacaact taaagaagat gtggaagagt 49321 cctaacggta caatcagggc gattcttgat ggtacggttt tccgtgcccc gatagttgta 49381 aacagcataa agccctttgt taaaggatgg aaaaaaccta tttccattgc aaggcatgct 49441 tacggtgacg tatacaagaa tgtggaatac tatgtgcctt cggcgggaaa agccgagctt 49501 gtatttacgt ctgaaaacgg agaggtttca aggcagacca ttcatgagtt tgacggtccc 49561 ggtgtgataa tgggtatgca caataccgac aaatccatca gaagctttgc aagggcctgc 49621 tttaactatg cccttgacat gaaccaggac ctctggtttt caaccaagga taccatttcg 49681 aagacatatg accataggtt taaagatata ttccaggaaa tctatgaaaa cgagtacaag 49741 gaaaaattcg aagccaagaa tttgcaatat ttctacactc tgatagacga tgctgtggca 49801 cgtattataa gatctgaagg cggcatggtt tgggcatgca agaattatga cggtgatgtc 49861 atgtccgata tggtggcttc tgcctttgga agtcttgcaa tgatgacgtc agttctggtt 49921 tcacccgacg gaaagtatga gtttgaagca gcacatggaa ctgttacaag acattattac 49981 aagcacctta aaggagaaga gacatccacc aactcaatgg caaccatatt tgcatggacg 50041 ggtgcattaa agaaacgcgg cgagctggat ggcataaaag agcttgttga ttttgcaacc 50101 aagcttgaac aagcatctgt tcagacaata gaaaatggtg taatgacaaa ggatcttgct 50161 tcgctttcag aagttccgga gaagaaaata gtaaatactg aggattttct taaagaaatc 50221 aggaaaactt ttgaaggtat ggcataaatg atattgcata tcatggattt gttaacccgg 50281 tacggtataa tcaaagccat accgggttat tttattgcaa catatataac aatagatata 50341 cttttatata tataacatgc cagtttatga gaaatacaaa aattacaata caaaatatac 50401 agcactgcca aacagttttt tccaagtgat tttgagtatt gtgaatttgt aacggagcaa 50461 ctttagttta ttttgaaggg ggagaataat gcaagaaccg gtatacacaa ttctgattgt 50521 agatgacaac gaaaataatt tgttttcttt gagaactctt atcgaagaac atataaatgc 50581 agatgtaaaa gaagctaatt cgggagaaaa ggcattaaaa attttgttta aagagagagt 50641 ggatcttatc attcttgata ttcaaatgga aggaatggac ggctttgagc tcgcttcgat 50701 aataaaaaag agaaaaaaga caagcagtat acctatagtt tttctgactg cttcctatat 50761 cggtgacgag tttcaaagaa gaggatttga gattggtgct gtggattacc tgacaaagcc 50821 tattgacgaa taccagctta ttaacagaat taatgtctac ctgaaaatga tagaaaaaga 50881 aaggactatg aacatacttc ttgaaaaaag ggtaagggag cagacagaag aattaagggc 50941 tgcaaaagaa gcagcagaag cggcgaatga agccaaaagc atttttcttg ccaatatatc 51001 tcatgagctt aggactccca tcaacatcct gtacagcaca acacagataa ttaattcata 51061 tctcaatgag gacaaggttc ttgacagaga aaaaattcga agtaagatag ccatgcagca 51121 gcaaaactgc tatcgtctgt tgaggcttgt caacaatctc attgacatta ccaaaataga 51181 ttcaggttat tttgaactta aattctctcg ttgcaatata gttgaagtgg ttgaaaatat 51241 tactttattg gttgtggaat atgccaaaaa caaaggggtc tccctcatat ttgacaccga 51301 tgtggaagaa aagatcattt cctgcgacca gaatgcaatg gagcgaataa tattaaacct 51361 tttgtccaat gcgataaaat tcacgccgag gggaggatct ataaaggttg aggtgaaaga 51421 ctgcggcaag actgttgcaa taagtgtgaa agataccgga ataggaatcc aggaggataa 51481 actggaaatg atttttgaaa ggttcaagca ggtggataac cttttgacca gaaaaaatga 51541 gggaagcggt attggtttga gcctggtcaa atcactggtg gaactgcacg gcggaaagat 51601 cagtgtaaag agtgagtaca acaggggaag cgagtttacg gttgaacttc ccgcggatct 51661 ggaaaacggg gaaaatcctt caatggatgc ggcggacaga aaagaagaaa acgaaaacaa 51721 gcagcacaat gtgcatatag aattttctga tatatactat tgacttttgt gattgatatt 51781 tgttgctgat tgggggaggt attgttaatg aaactgctga aaaatgtaag aattcaacac 51841 agaatgtggg cattgtttgc cgtttggctt atattgtatg tcatttttgc cgtagctgct 51901 tacagaaatg taagtgagat tgggcaagta tccgaagaca tttataccca gtcgctgaag 51961 acgtcaaatg ccgccagaga ggcaagggtg gcaataatga aaatacaaag aggaataaag 52021 gagattttgc tgtctgacaa tcctgataat gtctattacg aattggaaaa aatcagggaa 52081 ttggataatc aggttttgga aaactttgaa ataataaaat ccaattccgg cggtaatgaa 52141 gaaatagaga agcttgtaaa tgaatcaaca gaaatatttg acgaatggag aaaaacccgg 52201 ggggaaattg cggctctgat acagcaaaac aaacatttac aagatacaac tgctcttaca 52261 gtaaaaaata atgagtttgt tgaaaaattg gagaaatgcc tggacagtct ggataaaatt 52321 gaagaggatg aagcgcaaaa tcttatagac cgatccgcca aaatacagaa ataccataaa 52381 aacagtatat tctattggac cgggataata gtgtttactt cggttgttct gtttaccatt 52441 gtgatacgga gcataatgtg gcccgtttca tatttgcagc atataatgcg aaccagcgca 52501 aataccagag agattattga agctgaactt cccgggaaaa atgaattggt taacatggcc 52561 aattactaca acaagcttgt aagaaatcta aaggagcagt tctggataaa agacagttgc 52621 agtgctctaa atgaggaact tgccggcaaa tttgatctta aggaaattac ggataaagcg 52681 gtaacttttt tggcaaggat tttggatgca ggaaacggtg tgctttatct ttataatgat 52741 gaggataaaa agctgtattt gaattcatcc tatgccttta ccgaaaggga ccgtctgtca 52801 aaccaatatg aactgggaga agggataata ggtcaggtgg cccttgaaag aaagccgatt 52861 cttttaaaaa atgtcaaaag gcaggaagca ctgattacca cgggcaccgt aactgaagca 52921 cctcttaatg tttatgccgt gccgctctta tatcaaggtc atctttatgg cgtcttggaa 52981 ctgtcatctt ttgaaccttt tgtggaatta aaacaggaat tgatgaacga ggctgccaag 53041 attgtatcca cgtatttata taccgccgta caaaataaca ggattgtaaa cctcttgaaa 53101 attacagagg ctgcaaaaca agaggcgggc aggaaagcaa gcgagctgga agaggccaac 53161 agggtgctgg aagagcagca aattcttctg caaaaacaga ctgaagagct tcagcaaacc 53221 aatatccagc ttgaatatca gcagcagaaa cttcagcagc agagtgagga attgcagcag 53281 accaattccc agcttgagga acaacaacag cttcttgaag aacaggcaag gcttttgaat 53341 attaaaaatg aagatcttga aagaacaacc cgggagctta gattaagaac tgaagaattg 53401 gaaaaggtca ataaatacag atcagagttt ctggccaata tgtcccatga gctcaggact 53461 ccgctcaatt caattattct cctttccaaa atgcttgcac gaaagaaaat aaatgagttt 53521 gatgaaaaag atatggagaa gattgaggta atcaataaag ccggtcagga acttttgcgt 53581 ttaattaatg atgttttgga tctttccaaa gttgaatcgg gcaaaatgaa tttgaatatt 53641 ttcactttcc attccagtga actgatggag gacttaaggc agatgtttga aagctctgca 53701 aaagagaaaa atatatcctt ttttgtggag gattcaataa actccatgtt ggtcggagac 53761 agggataaaa tttcccagat actgagaaat ttcctttcca atgcgtttaa attcacttca 53821 gagggttctg taattttaaa ggcggaaatg gacaaggaca gagaaaacga tgtcatattc 53881 tcggtaaccg acaccggaat cggtattcct gaagaacaca tttctgatat attccaggag 53941 tttcggcagg tggacggaac aatatcaaga aagtatgggg ggaccggact tggtttgtcc 54001 atatcaaaga aacttgccga ccttatgaaa ggagaaatag aagtccgaag caaaattgga 54061 gagggaagta cgtttttcct caaactgccc ggtcttgttt gcaaaaaaga ggatggcagg 54121 gaaaaggtga cggtaaagaa agacatggac aggaaaatct caacggatcg aaaaaatgac 54181 aaggtaatac tggttattga agacaatgag aattttgcaa agtacctgaa agaaataaat 54241 gacggcatgg gatttgacac cattatcgca ggcagcggaa aggaaggcct ggagacagcc 54301 aaaaacacca gggtggacgg aattttgctg gacattatgc ttcctgatat gagtggaatt 54361 gaagtgctaa gagagctaaa aagcattgtg gagcttggaa aaattccggt acatgtaatt 54421 tccgaccttg aagaagatga cgtttcgcaa attattgcgt atttgttgaa ttattccgca 54481 cggcaccccg aacggattat gattgtcgga ggggatgcaa tctggcagag taccatcaaa 54541 aagccgtttg aagaaagaaa tataacaaca aaaacggtat cgactgagga agaggtaaag 54601 ttcgaattta aaaaggaaat gtatgatgct gtgattttga atatggaatt ggatgacaaa 54661 gatgttgcag gcatttgcga atatatagct gagcaaaatg tggacattcc tctgattgtt 54721 tacgccgaaa aaagtctttc acaagaacgg cagaaggaaa taaaaaaata tgcagataaa 54781 ataattatta agacagcgga ttcaaaagaa aggtttcagg atgaactgac tgctttcctt 54841 aaaggaatta aggaaaacat ggacaatggc tgctatttgt tttcgaaagt aaaaaaagaa 54901 tatgcgttga atttggacgg aaaaaccatt atgattgtcg atgatgacca cagaaatgtt 54961 tttgtcctgg cagcggctct tgaagattac ggagccaaca tcatagctgc ggaaaacggt 55021 aaaatggctc ttgaattgct taggaccaat aaagtagact taatattgat ggatattatg 55081 atgccggtga tggacggata tgagactatc agagcgataa agtgagataa agagctaaaa 55141 ggtattccgg ttatcgcagt tacggcaaag tctctgaaat ccgacaagga aaagtgcatc 55201 gaagccggag cggatgacta tatttcaaaa cctgtggatt acgatgtcct gatacggctt 55261 ataaaagcct ggacagccaa agaaaactaa gcgggcaaat ttaaaggaca aatttaacaa 55321 gcaattttag gctcttaaat ttaattctga ttattatgaa aatttacttt aattatcata 55381 aattattata tacggggttt ggggtgtagt tgtttgaata ttcataaagc cagaaacggt 55441 cacataatgc atatttcggt tatgggtgaa ttggactcaa aagccgacgt ggacaggctg 55501 ttggagtcta ttgatgaaaa ctgtgattgt gagatacatt taaccttttt ggatgcaaat 55561 gtcgttccga gggaaattgt ggaaaagatt gtaaagctca aggagcataa caaatgcaag 55621 atattcgtac ttaaagcata cctgtactca tattttttgt cccttggcat aagttgtttt 55681 ttggtaaaga aaaagtccat attgaataaa gattttgaga gcaaagaaaa actaagttcc 55741 cagacatttg agccggagaa agtggaaaag tttctttggg atatttacga caagtatgga 55801 ttcgacttta cagaatatcg gaaggatagt ataataagac gaataaaaat atcaatgtta 55861 agatattgca tgacaaattt tgatgaattc agccacctgg ctcttactga tcaggacgtg 55921 tttgaacagc tttttttgga tttttccatc aataccacaa attttttcag ggatccggaa 55981 gtctttatgt tcctgaggga aaaagtattg ctttttctgg attcctattc ccatatcaga 56041 atatggtgtg tgggctgttc aaacggaaag gagccttatt cgctggcaat aattctaaaa 56101 gaactgggca tgcttcacaa agtgcagatt tatgccactg atataaatcc ttatgtaatt 56161 gaagaggcaa agaacggtct ttattctgta agcacaataa acactgatat agccaattat 56221 aagaaatccg gtggttcaaa aaactttacc gactattttg aggtaaacgg caactacatg 56281 aaagttaagg atgattttaa agataatatt ttgttttttc agcacagcgt gattgaaaaa 56341 ggcatactca atgagtttca gatgattctt tgcagaaacg taatgattta ttttgatatt 56401 cctttgcaaa aaaaagtgct tcggcatttt tacaattctt tggattccgg aggattttta 56461 gtaatgggaa aaagcgaagg aatgcttctt aataacggat atgaatattt tgctgattat 56521 aatgaaaaat atagtgttta cagaagaaaa cattaatttt taaacgacca ataattataa 56581 aaaataattg agctgtagaa attcatataa tgaaaaaggt ttgagtctga tgaatgaata 56641 taaaaaggaa ataaagatat cggtaaggaa tctggttgag tttgtgttaa ggaccggtga 56701 cattgacagc tcttttaccg gaagcagcag ggccgtcgaa ggtacaaggc ttcataaaaa 56761 aatacagaaa acccagggca aggagtatag cccggaagtg tttctgaaaa ccactgttga 56821 gtttgacgac tttttcctca cagttgaagg acgggcggac ggtgtaataa atgaggacgg 56881 ctgttttata attgatgaga taaaaacaac aacggcacct ttggagttga tagatgaatt 56941 ctacaatccc ctgcactgga cacaggccaa atgctacgca tatatccatg cgttaaatga 57001 aaatttggag aaaataaaga taaggcttac ctattgccat ttggaaacag aagagataaa 57061 atacctggtc agtgaattcg attttgcaga gcttagccgg tttttcgagg aacttgttga 57121 aaaatattat gtatgggcaa agcttgcctg tgactggcag gttaaaaggg actgttcgat 57181 taaagttctt gagtttcctt ttgagaaata cagaaaaggt cagagaaaac ttgctgtggc 57241 tgtttacaag accgttacgg agggtaaaaa actttatgtg aaggcgccca caggtattgg 57301 aaagaccatt tcaaccctgt ttccggcagt caaggcaata ggggagggac atgcctcaaa 57361 aattttttac cttacggcaa agaccgttac aggcggtgtc gccaaagaag cttttgcaaa 57421 aatgaggcaa aagggacttt tatttaaaac ggtgactctc actgcaaagg aaaaaatatg 57481 ttttatggaa aaagccgtat gcaaaccgga aaaatgcgag tatgccaagg ggcattttga 57541 cagagtgaac gaggcaataa tggatatact gaccaatgag gatgaaatca aaagagaagt 57601 tatagaagag tatgcaaagg cccacagagt ttgtcccttt gagctggcgc tggatcttac 57661 catttgggcc gatgcggtaa tttgtgatta caattatgtg tttgatccga gggtgtacct 57721 gaaaagattt ttctccgatg cgggcggtga ctatattttt ctggtggatg aggcgcacaa 57781 ccttgtggac agggcaagag aaatgttttc ggcgcagctt tcgaaaaaga gctttcttga 57841 gctgaaaaag gcgatgaaag aggaaagtcc caaaatatcg aaaacactgc aaaagcttaa 57901 cacatttatg ctgggtatga aaaaactttg cggcgataac gactactttg taagcaagga 57961 ggagcaaagt gaaatatacc tgcttttaag aagacttatc ggtgaatgcg aagaatattt 58021 gacggacagg gcaaagaacg gaattgaaaa tgaggatttg ctgcagcttt attttgatgc 58081 ccttatgtat gtcaggatag ccgagtttta tgatgacagg tatgttacct ttgtggaaaa 58141 atccgataac gatgttagaa taaagctttt ttgtatcgac ccttcccatc ttttaagcga 58201 agctttaaaa agaggaaagg cagcggtttt cttttcggcc acgttgcttc ctttgagtta 58261 tttcaaggaa gttttgggag gagggccgga tgattacacg atgtgtttgg attcaccttt 58321 tgaagtgaat aacagatgcc tcatgatagc cgacagaata tccacccgtt atcaggacag 58381 gggcaaaagc tgcgatgagg tggtgcagtg cataaaatcc atcgtttgtg ccaaaaaggg 58441 aaattacatt gctttttttc cgtcctatca gtatatgaac atgatttatg aattgtttga 58501 aaaggaatgc ggtgatatta agctttatgt tcagtcttcc tccatgacgg aaaaggaaag 58561 ggaggatttt cttgagcgtt ttaaagcgga ccctcaggag acggtattgg gtttttgcgt 58621 gctgggaggg attttttccg aaggaattga tcttagggac gacaggctga taggggcgat 58681 tattgttggt gtaggtcttc cccagatatg tattgaaaga gatatcataa gggattatta 58741 tcagaataaa aaccggctcg gatttgaata ctcttacatg tatcccggca tgaacaaggt 58801 tatgcaggcg gcgggaagag ttataaggtc ggagaatgac aagggggtta tacttttaat 58861 tgatgacagg tttacaaacc caagttatct tgcccttttt ccaaatgagt ggttcccata 58921 tatcagagtt acggggaata atatatcaga gcatgtaaag aagttttgga gccgacatgg 58981 ggcttgaaac ggaaaatttt attggtataa tatcaacata aataaattgg tataatgatt 59041 ttcggaggag attggttatg gaagaagtga aaattggttt ccttggtttt ggaaatgttg 59101 gaaccggagc ttataaaatt attcgtgata acggtaatga tatttttcta agtgaaggag 59161 ttcggctgaa agttgcgaaa attcttgtaa gagatattaa taagaaaaga aatgtggaag 59221 ttgacaattc tattctgacg gataaatttg aagaaatagt agatgacccc ggaatctcca 59281 ttgttgctga attcatgggc ggtgtggagc ctgccaggga ttatgttgtt tcctgcctta 59341 agaataaaaa aaccgttgtg actgcaaaca aagagcttat tgccaaacat ggattggagc 59401 ttcaggcgct tgccaaagaa aacggagtgg gtctttatta tgaagcaagt gtggcaggag 59461 gtattccggt tataaagatt cttgcagagt cgcttcaggc aaacaaaatt ggcgaaatta 59521 tggggattat taatggtacc actaactata tacttacaaa gatgtccgag gagggaagaa 59581 gtttcagtga tgtgcttgca gaagcacaaa gactggggta tgcggaaccg gatcctactg 59641 ctgacataga aggctatgat gctatgtata aaatttccat attatcctcc atggcatttc 59701 ataaaaaggt ggatgttgac aaaatctaca gggagggtat tacccaaatt accccggaag 59761 atattgaata cggcagggag ctggggtttg caatccgtct tcttgccatt gccaaaaagc 59821 gcaacaatac catcgaagta agagtgcatc cgacatttat acctcttgac catcctttgg 59881 ctgctgtaag gcattccttt aatgcagtgt tccttaaagg ggacgccgtg gggaatataa 59941 tgctgtacgg cagaggagcc ggggaccttc ctacgggaag tgcaattgtg tcggatataa 60001 ttactgcatg ccatcagaag gacaagcaca gatatatcag tttttacaat gacgaagaag 60061 gctcagctga gaagataaaa ttcaatgatg actgggaaag cgaatttttt gtcagactta 60121 cggtaaagga caagccggga gttcttgcca aaattgccgg atgctttggc aaacacggag 60181 tgagtatagc atcggtaatt cagaaggaca ggggaaagga cgccgttcct ttgatatttg 60241 taacccattt ggccaaggag ctttcaatga aaaaagccat atctgatatt gcagaagttg 60301 aggatgtgtt aatggttgaa aatatcatac cggttgagcg ttaattgagt tataatatag 60361 ttgtaaataa atctgtaaat agagaaagta tcccttgggg cgagggatac ttcaagaagt 60421 ggtaagatga actgtagatt ttgaatctac agttgatagc atatgcagat ttagatgatt 60481 tcgtaaggta taacttatta agttatacct tatttacttt tcattaatac taattcgaaa 60541 ttttttttaa ttttattgtc gtaaaaaaat ttttttaata tttttacttt tttaaatttg 60601 tactctatat atagaatagt atagtgcagt tatactaacg gtttagcttt tcgcggagca 60661 gggcgccgtc agtaatcggt tcatgacaga caaagttttc gcagacgtaa gcagtaggtt 60721 tattttcaat tgtagtgtaa ttgtcgataa acggtatcag ttcttttaaa tccttgtgtt 60781 cttcggaata taaaattgaa gttgtgaaag gtctgaaatc ttcactgaga atactgagca 60841 tgttttgagt gtctttctca ttgctgccca ccagaacaac ttcatttgat ttggatttcg 60901 aaaaaagcat agctgtaagg aaaaaagcat atccttgcgg catgctgtca attttgcttc 60961 caaaaagggc aaacatctga tgggcttttt cttccaactc ctgctgccct gtcaaacgtg 61021 aaagtcttag aaaattcaaa gctgcaaccg aattaccgga cggaatggct ccgtcgtata 61081 tttcctttgg tctggtaatg agttgctcac tgtcgctgcc atatatgaaa agcccaccct 61141 ttttattgtc ccagaaatac ttaatcatgt cattggtcag ttccatggct tttttgagat 61201 acataggttt gtaagttgtt tcataaagct caataagagc ccagattaag aatgcatagt 61261 cgtcgagata tgccaaaaaa tgcggcttct ccgtccctgt accgcgcaag aagccttccg 61321 tcaggtctta cgagttttga gaatatgaat tcactggctt tctcagcggc gagagtgtat 61381 ttttcaatcc ccagaactct tccaccgatt gccagggcgg ctatcataag accgttccag 61441 gcagtcagga ttttgtcatc cttatgggga tgcacccttt tttctctgtg gtcaaagagt 61501 ttttttctgc acaattcgac aaactcctta tcttcgtcag gtattgtgct gtttataagg 61561 tttgggatgt tgagaccttc aaaatttcct tcttcggtga tgttgtaata tttgcagaat 61621 ttttcaccgt cgctttctcc caagacttct tttatttcag ttggagacca gatgtagaat 61681 tttccttctt cgccttcgga atctgcgtct tctgcgctgt agaatccacc ttccggtgat 61741 gtcatgtctc ttagcacata agtaaagatt tcttttgcaa tatcggcgta ttttttgttt 61801 tttgttgcct gataggtttc aagatatgct atggccagca atgcattatc atacagcatt 61861 ttttcgaaat gaggcaccag ccatttttca tcagtcgaat aacggcaaaa gccaaaacct 61921 atgtggtcat atattccgcc gctgtacatg gagtcaagag ttttttcgac catgacaagg 61981 gcatactcct ctttggcctt gtgccagtat ctcagaagaa aatacaggtt gtggggcata 62041 gggaacttgg gtgcgttccc aaatcctccg taaatgttgt caaagtcata tttgaactgc 62101 gaaaaggcat cttcaaatat gtcttctgta atttcatcga cagaatagta atagtcatca 62161 tcaattgatt cgctgattac actgactacc ttggagctgt atttggcaag tgaatctttt 62221 tcatttaccc aggtgttgtg tacgctcttg aggatggata taagtccggg cattcccata 62281 cggtcttttt tgggaaagta tgttccggca aagaaaggct ttttgtcggg agtcataatg 62341 attgtcagcg gccagccccc atgtcccgtc agtgcctgac aggcagtcat gtatatgctg 62401 tctatatccg ggcgttcttc tctgtccact ttgatggaaa caaagttttt gtttagaatt 62461 tcggcaactt cttcatcttc aaaggattca ctctccatca catggcacca gtggcaggtg 62521 gaatagccta tggagaggaa gatgggcttg ttttcccgtt tggctttttc aaatgcctca 62581 tcacaccagg gataccagtc tacagggtta tatgcatgct gcagcaggta aggggatttc 62641 tcatggatta gtctgttggc ttgtttataa gctgacatgt ggacttcacc ttcctttcat 62701 tttattattc tttttaccac tgaagtatta tttgaactta tgtaattttg tatgcaaagt 62761 taaagggtat agaatgacta taataaatca ttttattgag catgaaaaaa ataatatgat 62821 ggaattggaa ataaaaaaac taatttcgga gaaatgaaat ggaattgaaa ttttaatgaa 62881 aagtatatat ggtaatgagt aaattttaat gatactataa atgacagtaa tgattataag 62941 gtttattatt gggtgtcgta attggtttag caccggtgac aggtggagta gctttttggt 63001 ataataattt aaacataagt ttattacgtg aaaaatacaa atgtatggat taagaaagtc 63061 ttcaagttca gacctcaagc catctgtaag ctctctaaat tcatctgtca cgaccagtat 63121 accctatttg tgtttttgca cgggatacag tattatgtca aatcagtagt atgcattaat 63181 tacttttagt tcacagccca gtattttttc taattcagat aattgtggga cagttagttt 63241 gatttcagga ttgaaaactt caattacaaa ttttgaaaaa ccacaattct ctttatagat 63301 taagtcaaaa atttgagttg tttggctgca acagggtagt tcaaagaatg cttcaatgaa 63361 atgtttttca tatagtatac tcattgtttc accccaccat tccatattaa gtggctgctt 63421 gcaataaggg catacaactt cttgaaaatt ttcaccgcag tcaataaatt caatattatt 63481 agttattgat atttttattt tagtattact aaagatagaa tttaaatatt ccattaaagc 63541 tatctgagct gttgagtttg ggataaatga tgggattgag ggtataagtt ttaatatgct 63601 atcactcata gatgctcctc tcacaaatat attcaaattt tttttttgat atataactat 63661 ttcaaacttt attgaactga taatatttta tcattatgtt ttacgaattc aaccggaact 63721 tataaaacta ctgttagatg gacttgtgca tctccaataa acctatgagt ctccaaatca 63781 aacgcaatgt ttcatgttat gttgacaggc gaacatatgt ttgatatgat ttgcacatta 63841 gcttcttatg agatatgtga gatgaaaatg attaaaagaa tgcctaccca ttgtggggat 63901 gatacttgcc cttcatgtgt ggttgctgtt gacagaagga taatattgca ataaaattat 63961 taatatccac aactcgaaag gagaattaaa gtatgccggc tgttcttaac taaacaattt 64021 tatattgtat ttatattgta tctgataaaa gagttcagct aaacctatat tggtagtagg 64081 tttggtacag tattcttttg tcgggtttat tgttaagaac aacggtatta ttgcaacctt 64141 ttcattattt acaaagtgga tttcccgagc cttaactgca tagtgtcttt gtaatataca 64201 ggtgttatgt taagtgttgt tttggttttt attatgcctg tacttccaca tttgtgggtt 64261 atggctgctg gtatttaagt aaagaaaaac agtttataca gaggttgtaa atggactatt 64321 gttcatttgc agcctttttt atttagcctc ttggagtgaa atgaaagggg caaaagcgaa 64381 agggcttgat gtcctaagct ttatttatca ctgaaaggag gggaggccaa tgtttaatca 64441 gtagtttttc ttcgcatgga aaagtatttt tataaaacct gatttacttt gatgaggtga 64501 aattatgcaa attcatttta acaacaagaa tgacaaagaa tatcaattta tgcttaataa 64561 tttgctgaag gatattttcc tggacttcca attttggtat gatttaaacc tctgggatga 64621 aaattatgaa agctattcta ttgtcgaaaa cggagagata gtttcaaata tctgtgttta 64681 taagacacaa atactgttta accaaaaaca atattgcgct ttatccgttg gagctgttgc 64741 gacaaaaaag gaata //