LOCUS NZ_ACVX01000026 54624 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00063, whole genome shotgun sequence. ACCESSION NZ_ACVX01000026 NZ_ACVX00000000 VERSION NZ_ACVX01000026.1 GI:256005217 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 54624) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 54624) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000026. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..54624 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene 708..1136 /locus_tag="ClothDRAFT_2046" CDS 708..1136 /locus_tag="ClothDRAFT_2046" /inference="protein motif:PFAM:PF01584" /note="PFAM: CheW domain protein; SMART: CheW domain protein; KEGG: lip:LI1170 chemotaxis signal transduction protein" /codon_start=1 /transl_table=11 /product="CheW protein" /protein_id="ZP_05430185.1" /db_xref="GI:256005218" /db_xref="InterPro:IPR002545" /translation="MMNDLLTSQYVAYELAGEKYALKISDVYEIIKMQSITPIHNSKP FLEGVINLRGKIIPVANLHKRFGLGNYTHTKKTRIVVVKSRDEMIGIVVDKVNQVIRF SDIQPPPEMVAGIDGSYFEGVGITDEGVISILKIDKVLHE" misc_feature 732..1133 /locus_tag="ClothDRAFT_2046" /note="CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732" /db_xref="CDD:29682" misc_feature order(858..875,957..959,963..965,1116..1133) /locus_tag="ClothDRAFT_2046" /note="putative CheA interaction surface; other site" /db_xref="CDD:29682" gene 1151..3259 /locus_tag="ClothDRAFT_2047" CDS 1151..3259 /locus_tag="ClothDRAFT_2047" /inference="protein motif:PFAM:PF02518" /note="PFAM: ATP-binding region ATPase domain protein; CheW domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; P2 response regulator binding domain protein; SMART: CheW domain protein; ATP-binding region ATPase domain protein; Hpt domain protein; KEGG: nam:NAMH_0362 chemotaxis protein CheA" /codon_start=1 /transl_table=11 /product="CheA signal transduction histidine kinase" /protein_id="ZP_05430186.1" /db_xref="GI:256005219" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /translation="MASIFESPELIGAFIGEVEEQLQLLENNVVELEKNGGTAEVVQE LFRAAHTLKGSSATMGFEKMKTLTHEMENVLDKIRNGLLEISRPVIDVLFECLDCLNM LKEDFVSDSNNVKTEITPVITKLKEISSENETNNQNSDSDKAENLETGRREQPIFVLD EKQQEQINQALGIGQNVLVCEVEILEDSQMKSVRACLIMNFLNEWGTVINMVPNVMEI PIDSDVGKVAFLVVTQMSADELRQKVQNDLMDIKEVRVFPYFIQNSISQTKDGETGVR DKDNSSGVKTATEEKRVVHTVRIDVDRLERMMDLVGELVIEQIRIAQVANNLYNQYPS DETVDDLIGISNRVSILINELQEGIMKTRMIPVQQLFSRFPRMVRDLSVSLNKEVNLV LEGGETEIDRTIMEEMSDPLIHLIRNAIDHGIENPEIRKKLGKPEQGTLRVTALPEDS NVIITVEDDGAGIDPQEIKQSAIKKRIVTEQEANNMTEQQLINLIFQTGFSTSQKVSD VSGRGVGMDIVKTHIEKLNGIIDVETCAGSGTKFIIKLPIKLPLTLAILKGLLVKISN ETYALPMNNVVEIVRKPKNEIESINGQAVAVIRDRAIPLIWLHDYFGIPRGNERKNTL IVLLGIAEKRFGLVVDELIGNQEIVVTNLGSYIGKVEGISGATILGDRSVACILDVVG IAKIVNSRKVSRIDVEYSKQ" misc_feature 1250..3220 /locus_tag="ClothDRAFT_2047" /note="Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643" /db_xref="CDD:30988" misc_feature <1265..1450 /locus_tag="ClothDRAFT_2047" /note="Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088" /db_xref="CDD:28972" misc_feature order(1298..1300,1307..1312,1355..1357,1364..1366) /locus_tag="ClothDRAFT_2047" /note="putative binding surface; other site" /db_xref="CDD:28972" misc_feature 1298..1300 /locus_tag="ClothDRAFT_2047" /note="active site" /db_xref="CDD:28972" misc_feature 1676..1927 /locus_tag="ClothDRAFT_2047" /note="P2 response regulator binding domain; Region: P2; pfam07194" /db_xref="CDD:148665" misc_feature 2033..2236 /locus_tag="ClothDRAFT_2047" /note="Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895" /db_xref="CDD:145841" misc_feature 2384..2767 /locus_tag="ClothDRAFT_2047" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(2390..2392,2402..2404,2411..2413,2516..2518, 2522..2524,2528..2530,2534..2539,2687..2698,2744..2746, 2750..2752,2765..2767) /locus_tag="ClothDRAFT_2047" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature 2402..2404 /locus_tag="ClothDRAFT_2047" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature order(2528..2530,2534..2536,2687..2689,2693..2695) /locus_tag="ClothDRAFT_2047" /note="G-X-G motif; other site" /db_xref="CDD:28956" misc_feature 2825..3199 /locus_tag="ClothDRAFT_2047" /note="CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731" /db_xref="CDD:29681" gene 3294..7721 /locus_tag="ClothDRAFT_2048" CDS 3294..7721 /locus_tag="ClothDRAFT_2048" /inference="protein motif:PFAM:PF00015" /note="PFAM: chemotaxis sensory transducer; SMART: chemotaxis sensory transducer; KEGG: mxa:MXAN_6962 methyl-accepting chemotaxis protein" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis sensory transducer" /protein_id="ZP_05430187.1" /db_xref="GI:256005220" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /translation="MGFKKDVALKFVKNSELSEKVYKAASSAKKLDERLKDLSNITEQ VAKGANEQSSAVDSTNSMTERLSQSINGVVKNAEKLKELAGQSKKSLEDMVVVIKQVA GNSESTAKSVEEISVSIEQMGKSVKGVAGNAESLTRSAEEMSAAIQEIVGSIQQVAGN AESTASSVEQISSSIEQMGKSIKGVAGNAESLTGSAREATAAVQEMAASIQQVAGNSE STANSIEQISSSIEQMGRSINGVAVNAESLSNSAAEATNAIHSIVASIQQVAGNAEST ASSIEQISSSIEQMGKSIKGVAGNAESMSGSAQEASAAIQEIVASIQQVAGNSESTSS SVEQISSSIEQMGKSIKGVAGNAESLKGSADEATAAIQEIVASIQQVAGNAESTASSV EQISSSIEQMSKSIKGVAGNAESLTGSAEEASAAVQKIISSIQQVAGNSESTAKSVEE IALSIEKMGKSIQGVAANAESLKGSADVSAAAIQEIVASIQQVAGNAESTASSVEQIS SSIEQMGKSIKGVAGNADSLKGSADESAAAIQEMVASIQQVSDNAESTASSIEQISSS IEQMGKSIKGVAGNAENLKVSADEASAAIQEIVASIQQVAGNAESTAQSVEEISSSIE EMGKSIQGVAGNAEQLQKSAHETSQVVENMAASISQVAQNAQNVNKLSEKVRSDAIEG QKAVADTLVAIKDISEVIHRAEDVINGLGKSSEKIGSIIEVIDDIAEQTNLLALNAAI EAARAGEHGKGFAVVADEVRKLAERTATATKEISELIKGIQGETSQAIKAIEVGTQKV EHGSKLSDEAGKAIEKIVEGIENVNMEIRQITAATEEQNKGSMKIIEAVNMVTNQASQ VTQATKEQAASVENIVKGVANAREQVRQVTVAVKEQAKQGQNIITAVENVNNQAAQVT QATKEQTKGAEEIIKGVANAREQVRQVTVAVKEQAKQGQNIIQSIENVTQQTAQVAAA VKEQTVGVEEIIKGVANAREQIRQVTAAMKEQAKQSQTIVVAVENVTKQAAEVTQATK EQAKDVEDIIKGIENAREQMRQVTVAVKEQAEQGQNIVTAVENVTRQAAQVTDVTKEQ AKAVEDIVKGIENSREQVRQISAAVAEQAKQGQNIVAAVENVNKQAAQVAQAAREQTQ GVEEIIKGVANAREQVRQISAAVKEQAKQGQNIVIAVENVTNQASQVTQAAKEQAQGV EQIIKGVVNAREQVKQVTAAVKEQALQGQIVIKAVENVTNQAAQVTQAVKEQAAGAEE IIRNVANAREQVRQITVAVKEQARQGQDITASVQNVTDQAALVSNAVKEQTQGVEDII KGIDNAREQMRQVTATVKEQAKQGQNIVTAVENVASQAAQITNVTKEQANGVENIIRS VANAREQVKQITAAMKEQAVNADRVINNVEGVSIQAYEVADAAKVQANEVEQLAKYTS EIDRVINLNIKDVERTCAVTKELSEYSEDIMDALQELAK" misc_feature 5175..5951 /locus_tag="ClothDRAFT_2048" /note="Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283" /db_xref="CDD:128579" misc_feature 5376..5924 /locus_tag="ClothDRAFT_2048" /note="Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144" /db_xref="CDD:153541" misc_feature 6231..6959 /locus_tag="ClothDRAFT_2048" /note="Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283" /db_xref="CDD:128579" misc_feature 6726..7463 /locus_tag="ClothDRAFT_2048" /note="Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283" /db_xref="CDD:128579" gene 7885..8697 /locus_tag="ClothDRAFT_2049" CDS 7885..8697 /locus_tag="ClothDRAFT_2049" /EC_number="2.1.1.80" /inference="protein motif:PRIAM:2.1.1.80" /note="KEGG: dds:Ddes_1379 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type" /codon_start=1 /transl_table=11 /product="MCP methyltransferase, CheR-type" /protein_id="ZP_05430188.1" /db_xref="GI:256005221" /db_xref="InterPro:IPR000780" /translation="MDTFGLIQLAELIYEYCGIDFFKNLSSLESKISERLKELGLSCW EYGGYLRVEPKEWDTLIDLITVNETYFFREENLLEEFQKVILPKYKDRTPNNPLRIWS SACSSGEEPYTLAILSEETGLFETGAVEIIASDIDKKVLEKARRGLYNKKSFSFRTMP KEILDKYFISFGDDYKVKDSIRAMVDFRRVNLLDENILERVGEVDIVFCRNVLIYFDT KAINKVINSLYKVLRARGYLFLGHAETITGMNTGFETIYTPSAFYYRKGERH" misc_feature 7909..8682 /locus_tag="ClothDRAFT_2049" /note="Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352" /db_xref="CDD:31543" misc_feature 8083..8673 /locus_tag="ClothDRAFT_2049" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011" /db_xref="CDD:187159" gene 8697..9782 /locus_tag="ClothDRAFT_2050" CDS 8697..9782 /locus_tag="ClothDRAFT_2050" /EC_number="3.1.1.61" /inference="protein motif:PRIAM:3.1.1.61" /note="KEGG: aha:AHA_1386 chemotaxis-specific methylesterase; PFAM: CheB methylesterase; response regulator receiver; SMART: response regulator receiver" /codon_start=1 /transl_table=11 /product="response regulator receiver modulated CheB methylesterase" /protein_id="ZP_05430189.1" /db_xref="GI:256005222" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /translation="MQQYGVLVVDDSSFMRRCISLIIEKDPQLFVIGIARSGVEAIEK VHRLKPDIVTMDVEMPEMDGMTALKEIMRTCPVPVVMLSNRTDKDPKATFQALELGAA DFYLKSALLQENVKPEIIKEFLDKLKAIAQKARKTADKEREQNTASENMSEILENILN KPESSIETKSGSADLLIIGCSTGGPSALQSILPRFPKDTHVPIVVLQHMPPGFTKPLA ERFDAICNLHVKEAEDGDILEAGNIYIAPAGYQTFLDKKADNVIALRVEDCPAVETLY RPSINVTLDSAAPIYRERLLSVILTGMGNDGLIGCETVKKYNGKVIVEAEESCVVYGM PKVIYEAGLADVQVPLSNIFHEIMHYI" misc_feature 8697..9779 /locus_tag="ClothDRAFT_2050" /note="chemotaxis-specific methylesterase; Provisional; Region: PRK00742" /db_xref="CDD:179106" misc_feature 8715..9089 /locus_tag="ClothDRAFT_2050" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature order(8724..8729,8862..8864,8886..8888,8943..8945, 9006..9008,9042..9047) /locus_tag="ClothDRAFT_2050" /note="active site" /db_xref="CDD:29071" misc_feature 8862..8864 /locus_tag="ClothDRAFT_2050" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature order(8871..8876,8880..8888) /locus_tag="ClothDRAFT_2050" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature 9042..9050 /locus_tag="ClothDRAFT_2050" /note="dimerization interface; other site" /db_xref="CDD:29071" misc_feature 9219..9776 /locus_tag="ClothDRAFT_2050" /note="CheB methylesterase; Region: CheB_methylest; pfam01339" /db_xref="CDD:144802" gene complement(9805..10629) /locus_tag="ClothDRAFT_2051" CDS complement(9805..10629) /locus_tag="ClothDRAFT_2051" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cff:CFF8240_1231 amino acid ABC transporter, ATP-binding protein" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430190.1" /db_xref="GI:256005223" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /translation="MIDVINLKKSYGDLEVLKGITVSIKEGEKVAIIGPSGSGKSTFL RCLNCMEDPTSGSIIFEGVDIADMRVDINLYRRHMGMVFQQFNLFNNKTVIENIMLAP VYLGIHDLNVMKFKNFFIKFRNIFSKEKKPLYEINTTREKIKADARENAMRLLKRIGL EDKADVYPSTLSGGQKQRIAIIRALAMNPKVILFDEPTSALDPEMVGEVLDLIRQLAD EGMTMVIVTHEMGFAREVATRVLFMDDGRILEDNTPEEIFSNPQNPRTREFLSKVL" misc_feature complement(9808..10629) /locus_tag="ClothDRAFT_2051" /note="ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126" /db_xref="CDD:31323" misc_feature complement(9886..10626) /locus_tag="ClothDRAFT_2051" /note="HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262" /db_xref="CDD:73021" misc_feature complement(10507..10530) /locus_tag="ClothDRAFT_2051" /note="Walker A/P-loop; other site" /db_xref="CDD:73021" misc_feature complement(order(9946..9948,10042..10047,10378..10380, 10504..10512,10516..10521)) /locus_tag="ClothDRAFT_2051" /note="ATP binding site; other site" /db_xref="CDD:73021" misc_feature complement(10378..10389) /locus_tag="ClothDRAFT_2051" /note="Q-loop/lid; other site" /db_xref="CDD:73021" misc_feature complement(10090..10119) /locus_tag="ClothDRAFT_2051" /note="ABC transporter signature motif; other site" /db_xref="CDD:73021" misc_feature complement(10042..10059) /locus_tag="ClothDRAFT_2051" /note="Walker B; other site" /db_xref="CDD:73021" misc_feature complement(10024..10035) /locus_tag="ClothDRAFT_2051" /note="D-loop; other site" /db_xref="CDD:73021" misc_feature complement(9940..9960) /locus_tag="ClothDRAFT_2051" /note="H-loop/switch region; other site" /db_xref="CDD:73021" gene complement(10613..11323) /locus_tag="ClothDRAFT_2052" CDS complement(10613..11323) /locus_tag="ClothDRAFT_2052" /inference="protein motif:TFAM:TIGR01726" /note="TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: shl:Shal_3485 polar amino acid ABC transporter, inner membrane subunit" /codon_start=1 /transl_table=11 /product="polar amino acid ABC transporter, inner membrane subunit" /protein_id="ZP_05430191.1" /db_xref="GI:256005224" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /translation="MGNFDRKLIKFWEIFYNNKGYIKVLEGLKNTLYIAILGLVIGII IGTLIATVKVMPKYKKLPRILNAICDFYVGLFRGTPVVVQLLVAYYVVLPLLGINLSA LTVCVLVFGLNSGAYVSEIMRSGIMSVDHGQMEAGRALGLSYRVTMLKIVIPQAVKNI LPTLGNEFIALIKETSVVSFVGAADLYVAFSYIGTNSYEFMVPYLAMALIYIALVMII ASLIKVMERRLRKSDRRN" misc_feature complement(10952..>11140) /locus_tag="ClothDRAFT_2052" /note="Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427" /db_xref="CDD:185990" misc_feature complement(10670..>11035) /locus_tag="ClothDRAFT_2052" /note="Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261" /db_xref="CDD:119394" misc_feature complement(order(10712..10714,10742..10744,10751..10753, 10787..10789,11003..11005)) /locus_tag="ClothDRAFT_2052" /note="putative PBP binding loops; other site" /db_xref="CDD:119394" misc_feature complement(order(10676..10681,10688..10693,10697..10702, 10709..10714,10742..10747,10784..10789,10796..10807, 10826..10828,10835..10840,10880..10882,10931..10933, 10940..10945,10955..10957,10961..10966,10973..10975, 10979..10981,10985..10990)) /locus_tag="ClothDRAFT_2052" /note="dimer interface; other site" /db_xref="CDD:119394" misc_feature complement(order(10859..10861,10871..10876,10892..10930)) /locus_tag="ClothDRAFT_2052" /note="ABC-ATPase subunit interface; other site" /db_xref="CDD:119394" gene complement(11358..12221) /locus_tag="ClothDRAFT_2053" CDS complement(11358..12221) /locus_tag="ClothDRAFT_2053" /inference="protein motif:PFAM:PF00497" /note="PFAM: extracellular solute-binding protein family 3; SMART: extracellular solute-binding protein family 3; KEGG: shl:Shal_3484 extracellular solute-binding protein" /codon_start=1 /transl_table=11 /product="extracellular solute-binding protein family 3" /protein_id="ZP_05430192.1" /db_xref="GI:256005225" /db_xref="InterPro:IPR001638" /translation="MKKSFIFTVIMLMLFSLILAGCNSDSKVSGAKRAKVIDIQLTQE EYAFGVDKNQPELLAKVNEFISQIKSDGTLQKISDKYFSDGEPEPVISAVEDSSKDQL VVATNAAFEPFEYTLGGSEYYGIDMEIAALLAEYLGKELVIKNMDFDAVCLSVGQGKA DIAMSGLTVKEDRKEYVTFSDTYYNASQKLIVREDDNTFDNCKTAADVEAILSSLSSD TKIGVQTGTTGQFYVEGDEDWGFEGYNVKCVGYKSGSLAVQDMLNGNIDFVIIDEAPA DSIVRAINELN" sig_peptide complement(12156..12221) /locus_tag="ClothDRAFT_2053" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.384 at residue 22" misc_feature complement(11976..>12107) /locus_tag="ClothDRAFT_2053" /note="The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398" /db_xref="CDD:187020" misc_feature complement(12081..12098) /locus_tag="ClothDRAFT_2053" /note="hinge residues; other site" /db_xref="CDD:29040" misc_feature complement(<11400..11918) /locus_tag="ClothDRAFT_2053" /note="Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134" /db_xref="CDD:29040" misc_feature complement(order(11406..11408,11538..11540,11703..11705, 11778..11780,11892..11894)) /locus_tag="ClothDRAFT_2053" /note="substrate binding pocket; other site" /db_xref="CDD:29040" misc_feature complement(order(11427..11429,11445..11447,11457..11459)) /locus_tag="ClothDRAFT_2053" /note="membrane-bound complex binding site; other site" /db_xref="CDD:29040" gene 12546..13373 /locus_tag="ClothDRAFT_2054" CDS 12546..13373 /locus_tag="ClothDRAFT_2054" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430193.1" /db_xref="GI:256005226" /translation="MKLTEKHFIVGSSKNGYIFSFIIILALLTTFTACSENSAVNVET ESSSKSSKKIYLYGEKHGVKKIMDKEFELWHEYYNNKNMRHLFVELPYYTAEFLNIWM KSDSDEILDELYNDWIGTALYNPYTKEFYKKIKSNCPETIFHGTDVGHQYDTTGQRFL KYLEENNLKDSEKYRLAHEAVKQGKYYYENSDDVYRENKMVENFIREYDALNGECIMG IYGNAHTSLDAMDFTDSVPCMANQLKDIYKDIIYSEDLSWLAMNPFERIVYWLFEKK" sig_peptide 12546..12653 /locus_tag="ClothDRAFT_2054" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.923) with cleavage site probability 0.744 at residue 36" gene complement(13417..14595) /locus_tag="ClothDRAFT_2055" CDS complement(13417..14595) /locus_tag="ClothDRAFT_2055" /inference="protein motif:PFAM:PF00004" /note="PFAM: AAA ATPase central domain protein; peptidase M41 FtsH extracellular; SMART: AAA ATPase; KEGG: hypothetical protein ; K03798 cell division protease FtsH" /codon_start=1 /transl_table=11 /product="AAA ATPase central domain protein" /protein_id="ZP_05430194.1" /db_xref="GI:256005227" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR011546" /translation="MKNKRNVLIISIAIIAVIVGITLYFERDNSQYMPYPDFYNYVKS GKVVSAKIGNDEVRFYLNGDQTEYRTDNPELDSFKEFLLLNGVKVTSEKSADELFVTV TDAIFSIIFFGIIIFGLYKFIDFRRSTFKVIRNNDTKFSDVAGMEDLKREMLQAVDIL KHPKEYAAKGIRPINGILLEGNPGNGKTLFARALAGEAKVNFIATKATDFQSAIMSIG PAKIKALFRKARANKPCIIFIDEFDGIGEKRNYAGTGIDKENNRIIAAMLNEMDGFTR EGGVMVIAATNNYKALDEALVRPGRFDKKYTVPNPDYKTRIELIKIYTKNKKLSESIS IEQLAAKFEGMTCSQIETILNEAAVIATGEGHSDITESDLIEAVKKICHLTTVGVKRK " misc_feature complement(<13450..14526) /locus_tag="ClothDRAFT_2055" /note="ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465" /db_xref="CDD:30813" misc_feature complement(13681..14166) /locus_tag="ClothDRAFT_2055" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009" /db_xref="CDD:99707" misc_feature complement(14032..14055) /locus_tag="ClothDRAFT_2055" /note="Walker A motif; other site" /db_xref="CDD:99707" misc_feature complement(order(13735..13737,13876..13878,14029..14052)) /locus_tag="ClothDRAFT_2055" /note="ATP binding site; other site" /db_xref="CDD:99707" misc_feature complement(13873..13890) /locus_tag="ClothDRAFT_2055" /note="Walker B motif; other site" /db_xref="CDD:99707" misc_feature complement(13693..13695) /locus_tag="ClothDRAFT_2055" /note="arginine finger; other site" /db_xref="CDD:99707" gene 14851..15057 /locus_tag="ClothDRAFT_2056" CDS 14851..15057 /locus_tag="ClothDRAFT_2056" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430195.1" /db_xref="GI:256005228" /translation="MSSEGWALKKFFQAVLILEIVCLLVEIIAAIESPLFWIFAIMIG IFVLVLLRMVWRCEWKIEQLRREK" gene 15206..16372 /locus_tag="ClothDRAFT_2057" CDS 15206..16372 /locus_tag="ClothDRAFT_2057" /inference="protein motif:COG:COG1106" /note="KEGG: pnu:Pnuc_1118 SMC domain-containing protein" /codon_start=1 /transl_table=11 /product="ATPase-like protein" /protein_id="ZP_05430196.1" /db_xref="GI:256005229" /translation="MLAKIIMKNFKSFKNETVIDFTRINYKFLENNVSNNGVLKGVAF YGANASGKSNVLWAIRFLLDELFGEEKNPVTFMKCLFSDEPEFSLQYFFVIESREIHY LIDFHTEKGIINEELYLDRKLLLQRMGSTAKSGITEKKVYTDLNNKVLFLRTVYFNTG FSGDDKDNNANNNILRQWFDYMQNSIYVNPFLHRGIAYGKQDVVLNKYLENEGVKEIN RFFTKYNFEYTLDYLNERKVKDVTEIVNDDNIKLVFFNRKGVNVPIPYVLESHGNQNL LNILPCFLRVVQNSGMLLVDEFSGGLHNELERLLVNYFFDNAKNSQIFFVSHSTNLLS TSILRPDQIYAVEFNGEHGSQVKRFSEEQPRLAQNLEKMYLSGVFGGLPNYEDK" misc_feature 15206..16228 /locus_tag="ClothDRAFT_2057" /note="Predicted ATPase [General function prediction only]; Region: COG4637" /db_xref="CDD:34256" misc_feature 15215..>15418 /locus_tag="ClothDRAFT_2057" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" misc_feature 15341..15364 /locus_tag="ClothDRAFT_2057" /note="Walker A/P-loop; other site" /db_xref="CDD:72971" misc_feature order(15350..15355,15359..15367) /locus_tag="ClothDRAFT_2057" /note="ATP binding site; other site" /db_xref="CDD:72971" gene 16457..17077 /locus_tag="ClothDRAFT_2058" CDS 16457..17077 /locus_tag="ClothDRAFT_2058" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430197.1" /db_xref="GI:256005230" /translation="MGYEYIEKRRNNAEFFKNRNRSTSKVAVINTEESNISSISDKND YLDRIFEILISEYDFPVDNTAIYYIFDRDPKSNLDKGLIRKLIGQLKNAYENYNGQRG GVLLLSCPSIGAYIVSNFIDDTYLMEFDIGNKVKEYIATQNREVQLNRITTETLERAA NEMMKYFEAEKIDFCIDNIGQMNREVFERQEAKYRKERVYNLVSLL" gene complement(17368..18489) /locus_tag="ClothDRAFT_2059" CDS complement(17368..18489) /locus_tag="ClothDRAFT_2059" /inference="protein motif:COG:COG3581" /note="KEGG: sfu:Sfum_1830 CoA enzyme activase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430198.1" /db_xref="GI:256005231" /translation="MKITFPHMGDTYIPVKVLLETAGIDYVMPPVSDRSLLEQGILHS PEFACLPFKTIMGDFIYGIEHGADWILFGGGCGQCRFGYFGKLQAEILKSIGYDVNFI YIDLSNISVKEVLEKIRPLTEGKSIFELLKAIFYAVKTVFAVDRINELARFTRCREIN KGETDRIMTEFHNEIQKARGYKSINKIIHSTAKKLRKMPLDKKYRPIRVSIVGEIYIA AYPGINFEIERKLGNMGVEVHNTMSMSFWIKEHFIKKLLPFKIKNKNHEAGKEFMNTD DIGGHGLSSIGASIRSAKKGFDGVVHIYPFTCMPEIIAQSTFSEVQKKYGIPIITLII DEMTGEAGYMTRLEAFVDMIKMRRKPSYFPMPRFFSQKI" misc_feature complement(17413..18489) /locus_tag="ClothDRAFT_2059" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581" /db_xref="CDD:33381" misc_feature complement(17377..18438) /locus_tag="ClothDRAFT_2059" /note="CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl12083" /db_xref="CDD:159743" gene complement(18494..19408) /locus_tag="ClothDRAFT_2060" CDS complement(18494..19408) /locus_tag="ClothDRAFT_2060" /inference="protein motif:COG:COG3580" /note="KEGG: sfu:Sfum_1829 putative CoA-substrate-specific enzyme activase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430199.1" /db_xref="GI:256005232" /translation="MVTVGIPKGLFYFEHHVLWENFFCNLGCNVKVSDDTNKEILDWG VKHCSNETCLPVKVFHGHAYSLKDKVDYIFIPRYTSVDKNEYTCPKFCGLPDMTLLNL KRQIKLLEVKINVDAKPQETFKSFREISKTLNIPYSDVVEAFRAALKTYDNSRKNIRI EEQLNNNTGKTAISLLGHPYMIYDGYLSMKLIDKLKARNITVLTPRDIDHETKRKNAY PFEGKVFWDVGFELLGSAFTFASYPDVKGIIYLTPFACGVDAFVLEFIERRLKERYNM PLLKLTIDEHTGEAGFDTRLEAFLDMIG" misc_feature complement(18785..19402) /locus_tag="ClothDRAFT_2060" /note="CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl12083" /db_xref="CDD:159743" misc_feature complement(18500..>18676) /locus_tag="ClothDRAFT_2060" /note="2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050" /db_xref="CDD:147940" gene 19838..20374 /locus_tag="ClothDRAFT_2061" CDS 19838..20374 /locus_tag="ClothDRAFT_2061" /inference="protein motif:PFAM:PF00404" /note="PFAM: cellulosome protein dockerin type I" /codon_start=1 /transl_table=11 /product="cellulosome protein dockerin type I" /protein_id="ZP_05430200.1" /db_xref="GI:256005233" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MKKKIALLTVVLIVAMVVLGGSMTAYAGHQCSVTVIIGDVNLDG SVDSIDLALLYNTTYYAVPLPNRLQYIAADVNYDSSCTMLDFYMLEDYLLGRISSFPA GQTYTVYYGDLNGDQLVTTTDQSLLSDYLLGRINLTFRQYVSADVNGDGTVDGIDLAI ITAYINGQIQHFPVCPQS" sig_peptide 19838..19921 /locus_tag="ClothDRAFT_2061" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.877 at residue 28" gene 20717..22339 /locus_tag="ClothDRAFT_2062" CDS 20717..22339 /locus_tag="ClothDRAFT_2062" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ATGCN5; ATGCN5 (Arabidopsis thaliana general control non-repressible 5)" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430201.1" /db_xref="GI:256005234" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /translation="MLILEAHNIKKYYSDRLVIEIDDLKIYSGDKIGIIGQNGSGKTT LLNILAKEIEPDEGFVRQFCDIAYIRQFSEESICADKKLLKEFDLSQKVHQKVFSGGE KTRIKIANAFNRENLLVFADEPTANLDYKCIELLKQKLQSVESFLLISHDRNLLDSIC NKIIEVRDGKLYFYNGNYSFYKKQREMEYNREIFEYEKYINEKSSIEEAIMGRQNLAK SMRKTPKRMGNSEARLHKRKTTQKQEKINNKINSLKTRLEKLEVKEKPKEVPKIKLDF SLTNPPENKVVISADKLSFSYGNKKIFDKAGFKILNGSKTALWGENGTGKSTLLNLIF EKTDKNIYIAPKVKIGYFHQDFENLDYDKSVLENVMRDSVQNQTVARTILARLLIKND DVNKKVGCLSGGERVKVSFAKLFVSDANVLLLDEPTNYLDMSSMEALESVLCEYEGTV LFVSHDSAFVNAVADRLLVIENHTITEFEGNLDDYRQKMNETSKKVKDETEKIIIRMK MAEIAAKLSVPGTDKEALEEEYRRLAALLGNM" misc_feature 20726..21226 /locus_tag="ClothDRAFT_2062" /note="ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221" /db_xref="CDD:72980" misc_feature 20744..22171 /locus_tag="ClothDRAFT_2062" /note="ATP-binding cassette protein, ChvD family; Region: ABC_ABC_ChvD; TIGR03719" /db_xref="CDD:163431" misc_feature 21578..22138 /locus_tag="ClothDRAFT_2062" /note="ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221" /db_xref="CDD:72980" gene complement(22397..23065) /locus_tag="ClothDRAFT_2063" CDS complement(22397..23065) /locus_tag="ClothDRAFT_2063" /inference="protein motif:TFAM:TIGR00309" /note="TIGRFAM: V-type ATPase, D subunit; PFAM: H+transporting two-sector ATPase D subunit; KEGG: similar to ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D ; K02149 V-type H+-transporting ATPase subunit D" /codon_start=1 /transl_table=11 /product="V-type ATPase, D subunit" /protein_id="ZP_05430202.1" /db_xref="GI:256005235" /db_xref="InterPro:IPR002699" /translation="MAIMRVNPTRMELTRLKKRLQVARRGHKLLKDKLDELMKQFLDL VRKNKELREKVEEMLMKAHQDFLIARAVMSSEGLEAALMLPKQSISLDVSTQNIMSVE VPVLKFTTSSSDESDIYPYGFASTSGELDGAILTLSKVLPYMLELAQMEKSSQLLAQE IEKTRRRVNALEYVMIPRLTETIKYISMKLDENERGNITRLMKVKDMMLEQAHNFKEK LNEA" misc_feature complement(22448..23065) /locus_tag="ClothDRAFT_2063" /note="ATP synthase subunit D; Region: ATP-synt_D; cl00613" /db_xref="CDD:186107" gene complement(23163..24545) /locus_tag="ClothDRAFT_2064" CDS complement(23163..24545) /locus_tag="ClothDRAFT_2064" /EC_number="3.6.3.14" /inference="protein motif:PRIAM:3.6.3.14" /note="PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; KEGG: Os06g0568200; hypothetical protein ; K02147 V-type H+-transporting ATPase subunit B" /codon_start=1 /transl_table=11 /product="H(+)-transporting two-sector ATPase" /protein_id="ZP_05430203.1" /db_xref="GI:256005236" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /translation="MLKEYRTITEVAGPLMLVQKVEGVKYGELGEIELANGEIRRCKV LEVDGQNALVQLFESSTGINVATSKVRFLGRSIELPVSMDMLGRVFSGMGKPLDGGPN IIPDKRLDINGLPMNPAARNYPSEFIQTGISAIDGLNTLVRGQKLPIFSGSGLPHAQL AAQIARQAKVLGTDSKFAVVFAAVGITFEEADYFISDFKRTGAIDRTVLFINLANDPA IERISTPRMALTAAEYLAFDKGMHVLVIITDITNYAEALREVSAARKEVPGRRGYPGY LYTDLATIYERAGRRIDSEGSITLIPILTMPEDDKTHPIPDLTGYITEGQIILSRELH RKGVTPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFAAYARGKEAKELAVILGDA ALSDTDKLYAKFADAFEKEYVSQGFNEDRSIEKTLEIGWKLLSILPRSELKRIRDEYL DKYLPKAAEN" misc_feature complement(23178..24542) /locus_tag="ClothDRAFT_2064" /note="V-type ATP synthase subunit B; Provisional; Region: PRK04196" /db_xref="CDD:179779" misc_feature complement(24324..24524) /locus_tag="ClothDRAFT_2064" /note="ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874" /db_xref="CDD:145823" misc_feature complement(23493..24320) /locus_tag="ClothDRAFT_2064" /note="V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135" /db_xref="CDD:30001" misc_feature complement(24072..24095) /locus_tag="ClothDRAFT_2064" /note="Walker A motif homologous position; other site" /db_xref="CDD:30001" misc_feature complement(23799..23810) /locus_tag="ClothDRAFT_2064" /note="Walker B motif; other site" /db_xref="CDD:30001" misc_feature complement(23187..23447) /locus_tag="ClothDRAFT_2064" /note="ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306" /db_xref="CDD:144044" gene complement(24547..26337) /locus_tag="ClothDRAFT_2065" CDS complement(24547..26337) /locus_tag="ClothDRAFT_2065" /EC_number="3.6.3.14" /inference="protein motif:PRIAM:3.6.3.14" /note="PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; KEGG: hypothetical protein LOC100137685" /codon_start=1 /transl_table=11 /product="H(+)-transporting two-sector ATPase" /protein_id="ZP_05430204.1" /db_xref="GI:256005237" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /translation="MSKEGINVSQGTIVKVSGPLVIAEGMRDANMFDVVRVSEHRLIG EIIEMHGDRASIQVYEETAGLGPGEPVVSTGAPLSVELGPGLIENIFDGIQRPLVKMR EMVGSNITRGIDVTALDRSKKWDFQPTVKKGDKVTAGDVIGKVQETSIVEHRIMVPYG VQGTIEEIKSGSFTVEETVAKVRTENNELVDICMMQKWPVRIGRPYREKLPPNAPLVT GQRVIDTLFPLAKGGVAAVPGPFGSGKTVVQHQLAKWADADIVVYIGCGERGNEMTDV LKEFPELKDPKTGESLMKRTVLIANTSDMPVAAREASIYTGMTIAEYFRDMGYSVALM ADSTSRWAEALREMSGRLEEMPGEEGYPAYLGSRLAQFYERAGRVVCLGSDGREGALT AIGAVSPPGGDLSEPVTQATLRIIKVFWGLDSSLAYRRHFPAINWLQSYSLYLDIIGK WISENISRDWETLRSDTMRILQEEAELEEIVRLVGVDALSPSDRLTLEAAKSIREDYL HQNAFHEVDTYTSLNKQYRMLKLILGFYYSGKKALEAGVSIKELFELPVREKIGRAKY TPEDQVNSHFNEIEKELNEQIEALIAKEVQ" misc_feature complement(24559..26313) /locus_tag="ClothDRAFT_2065" /note="V-type ATP synthase subunit A; Provisional; Region: PRK04192" /db_xref="CDD:179776" misc_feature complement(26113..26301) /locus_tag="ClothDRAFT_2065" /note="ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874" /db_xref="CDD:145823" misc_feature complement(25006..26109) /locus_tag="ClothDRAFT_2065" /note="V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134" /db_xref="CDD:30000" misc_feature complement(25600..25623) /locus_tag="ClothDRAFT_2065" /note="Walker A motif/ATP binding site; other site" /db_xref="CDD:30000" misc_feature complement(25330..25344) /locus_tag="ClothDRAFT_2065" /note="Walker B motif; other site" /db_xref="CDD:30000" misc_feature complement(<24727..24936) /locus_tag="ClothDRAFT_2065" /note="ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306" /db_xref="CDD:144044" gene complement(26420..26740) /locus_tag="ClothDRAFT_2066" CDS complement(26420..26740) /locus_tag="ClothDRAFT_2066" /inference="protein motif:PFAM:PF01990" /note="PFAM: Vacuolar H+transporting two-sector ATPase F subunit" /codon_start=1 /transl_table=11 /product="Vacuolar H+transporting two-sector ATPase F subunit" /protein_id="ZP_05430205.1" /db_xref="GI:256005238" /db_xref="InterPro:IPR008218" /translation="MYKVGVVGDKDSILGFKALGMSVFPVTSASEAQETVEKIASMEY AVIYITEQFAKDIVSTIDKYKDHKLPAIIPIPGNQGSLGIGMMNVKKSVERAVGADIL FGDE" misc_feature complement(26435..26740) /locus_tag="ClothDRAFT_2066" /note="ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632" /db_xref="CDD:186115" gene complement(26733..27752) /locus_tag="ClothDRAFT_2067" CDS complement(26733..27752) /locus_tag="ClothDRAFT_2067" /inference="protein motif:PFAM:PF01992" /note="PFAM: H+transporting two-sector ATPase C (AC39) subunit" /codon_start=1 /transl_table=11 /product="H+transporting two-sector ATPase C (AC39) subunit" /protein_id="ZP_05430206.1" /db_xref="GI:256005239" /db_xref="InterPro:IPR002843" /translation="MPKLKKIDESKYIYAVSRIRAIEKRLLDKVKLDRMVEAKSADES LKVLLESGYGSGDGDIKSVFEYENILKEEHKKVYSLLNELAPKQETINMFLLSNDYHN VKVILKAEFSEQDETSLLIEPGSIPVSELKLMIKDRNMSKMPSIMRKAVEEAIDTYSR TNDPQVIDLILDKANYVHMKSISDSLDNKFINELVVILIDLRNINIFLRVKNLKKSWD FLQKVFIPGGHIGIKVFIENFDAPLESLVEELRFTQYGPLLEDGIESLRSTGSLTKFE KLSDNFITSYVKKAKYITFGIEPLIGYLMAKETEIKNARIIMVGKINNISNDVIRERL RESYV" misc_feature complement(26745..27740) /locus_tag="ClothDRAFT_2067" /note="Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527" /db_xref="CDD:31716" misc_feature complement(26745..27740) /locus_tag="ClothDRAFT_2067" /note="ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660" /db_xref="CDD:186131" gene complement(27790..28386) /locus_tag="ClothDRAFT_2068" CDS complement(27790..28386) /locus_tag="ClothDRAFT_2068" /inference="protein motif:PFAM:PF01991" /note="PFAM: H+transporting two-sector ATPase E subunit; KEGG: hypothetical protein ; K02150 V-type H+-transporting ATPase subunit E" /codon_start=1 /transl_table=11 /product="H+transporting two-sector ATPase E subunit" /protein_id="ZP_05430207.1" /db_xref="GI:256005240" /db_xref="InterPro:IPR002842" /translation="MAGVEKIKERILEEARAQAEANIKRAEEEAAKIIEEAQKEAAAK KAQILEKAKQEAVDVKKRLKAMAELEARKKKLQARQEVVDEAFNKTIEKLNSLPDREY EEIISQMIVNSVESGSEEIILSPKDKQRISPGFIENINKKLSQKGIDGKIKLSEETKN ISGGFILKSGDIEINNSFEAIIRMKREEVEAEVIKALF" misc_feature complement(27793..>28209) /locus_tag="ClothDRAFT_2068" /note="ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975" /db_xref="CDD:186725" gene complement(28413..28880) /locus_tag="ClothDRAFT_2069" CDS complement(28413..28880) /locus_tag="ClothDRAFT_2069" /inference="protein motif:PFAM:PF00137" /note="PFAM: H+transporting two-sector ATPase C subunit; KEGG: GK18316 gene product from transcript GK18316-RA" /codon_start=1 /transl_table=11 /product="H+transporting two-sector ATPase C subunit" /protein_id="ZP_05430208.1" /db_xref="GI:256005241" /db_xref="InterPro:IPR000245" /db_xref="InterPro:IPR002379" /translation="MLEILTGNFFAILGASLAFMFGGFGSSKGVGLAGEAGAGVLTED PGKFGPVMVLQALPSTQAIYAFVIAFLTIQKVVMGEPLSIAEGFILFAGCLPVGFVGW ISGIFQGRVAAAGINMIAKRPEGLGRAIVMALMVEMFAILGFIVSILMIGKVA" misc_feature complement(28416..28880) /locus_tag="ClothDRAFT_2069" /note="V-type ATP synthase subunit K; Validated; Region: PRK06558" /db_xref="CDD:180623" sig_peptide complement(28791..28880) /locus_tag="ClothDRAFT_2069" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.909) with cleavage site probability 0.331 at residue 30" misc_feature complement(28422..28619) /locus_tag="ClothDRAFT_2069" /note="ATP synthase subunit C; Region: ATP-synt_C; cl00466" /db_xref="CDD:186016" gene complement(28897..30852) /locus_tag="ClothDRAFT_2070" CDS complement(28897..30852) /locus_tag="ClothDRAFT_2070" /inference="protein motif:PFAM:PF01496" /note="PFAM: V-type ATPase 116 kDa subunit; KEGG: gur:Gura_0418 H(+)-transporting two-sector ATPase" /codon_start=1 /transl_table=11 /product="V-type ATPase 116 kDa subunit" /protein_id="ZP_05430209.1" /db_xref="GI:256005242" /db_xref="InterPro:IPR002490" /translation="MAIVKMNKISLIGLESEKERILENLMKLGVVEITDAKEKISSDE WKELVNIDGDSESVSRLDAQIDRVSAVIDYLDKFDKRKKPLFSARRDISTSELNMVLQ NQDKLWSVIDEVNRYDEMLANLKAEKNRNSNMILSLKPWEALDIPLELTATASSTVLI GVVPEMANTDKIKQDLDEKVPESHFEVLSRDKEQSYLLIIYLTSKEEDVMNVLKQYGF SKVTFKELSGTVKHNIDQALENIERIEEEIEYIEENMTSYVKYKDDLEVLHDYLSIER ERKIVLSNLLKTNKVFMLEGWLPENSAEEVKTFLEKSSDCYIEIVKPKEDEEFPVLLA NRAIPSTVESITNMYSVPNCKEIDPNAIMAPFFILFFGLMLSDGGYGAIMTILATIIL KVFKLEESTKKFMKLMVYCGISTMFWGLLFGGWFGIPNIPAVWFNPTEDPELLLSFSL LFGAIHIYVGLGVRAANLIKDKKYLDAVFDSLFWYILFTGFILFVLPYIPKIDAESVT GLVNLGKYLMIIGAVLLILTQGRGNKNIIAKLFGGVASLYDLISFMSDVLSYSRLLAL GLATSVIASIINQMATMFGFNNILKIIAVVAILAFGHLFNFAINALGAYVHSCRLQYI EFFGKFYKGGGTAFEPFKAKTKYINLK" misc_feature complement(28906..30852) /locus_tag="ClothDRAFT_2070" /note="V-type ATP synthase subunit I; Validated; Region: PRK05771" /db_xref="CDD:180249" gene complement(30839..31165) /locus_tag="ClothDRAFT_2071" CDS complement(30839..31165) /locus_tag="ClothDRAFT_2071" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: aeh:Mlg_2873 F0F1 ATP synthase subunit B" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430210.1" /db_xref="GI:256005243" /translation="MSLDIIKSIKQSESEAEQIKRQSLEEARQILSEASTQSYKLLEQ AQEDAEKEAKKIIQEAEKEANAEIEKFAAEISSECDSIKQNARKKLDKAVEIIIGRIV SPNGNS" gene 31550..32386 /locus_tag="ClothDRAFT_2072" CDS 31550..32386 /locus_tag="ClothDRAFT_2072" /EC_number="4.2.1.51" /inference="protein motif:PRIAM:4.2.1.51" /note="PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: ank:AnaeK_2061 prephenate dehydratase" /codon_start=1 /transl_table=11 /product="Prephenate dehydratase" /protein_id="ZP_05430211.1" /db_xref="GI:256005244" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /translation="MVKIGFLGPKGTFSQEAMLAYTKGSNDFVGVDYNTMVELIMAVE NDEIDEAVVPIENSLEGAVSTTMDMLAWDVDLKIKAEVVIEIKQNLMAKKGTDIKDIK YILSHPQPVGQCRKFLNSVFPHAVVKYVYSTAQAAKEVAQGDGNMASIGSLAAAKEYG LEVLKESIQDNDKNFTRFVVISKKEAKKAEKNKTSIVFSTENKPGSLYRILDIFNLWD INMTRIESRPAKNELGKYIFFVDINGHIEDEDVRDALTMVRRKTSFYKFLGSYPEFEI GC" misc_feature 31550..32380 /locus_tag="ClothDRAFT_2072" /note="prephenate dehydratase; Provisional; Region: PRK11898" /db_xref="CDD:183366" misc_feature 31559..32095 /locus_tag="ClothDRAFT_2072" /note="Prephenate dehydratase; Region: PDT; pfam00800" /db_xref="CDD:144409" misc_feature 32129..32365 /locus_tag="ClothDRAFT_2072" /note="C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905" /db_xref="CDD:153177" misc_feature order(32162..32173,32222..32233) /locus_tag="ClothDRAFT_2072" /note="putative L-Phe binding site; other site" /db_xref="CDD:153177" gene 32518..32859 /locus_tag="ClothDRAFT_2073" CDS 32518..32859 /locus_tag="ClothDRAFT_2073" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430212.1" /db_xref="GI:256005245" /translation="MALFDREIDITRNIKIIEWLKSELLTDIANLFKVLVNGVREEVH ESVAETLSNIILICYMLGRRLGVSYNSIEIKINNKIKLGIIENHDVEKYYGDLTELAK HLNSSRMQNKV" gene 32885..34894 /locus_tag="ClothDRAFT_2074" CDS 32885..34894 /locus_tag="ClothDRAFT_2074" /inference="protein motif:PFAM:PF01368" /note="PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: gme:Gmet_1578 polyA polymerase family protein" /codon_start=1 /transl_table=11 /product="phosphoesterase RecJ domain protein" /protein_id="ZP_05430213.1" /db_xref="GI:256005246" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /translation="MESKKFIGMFLPKSSFYLLIIFFLLIIISILEFTVAIPGYALFL LLLYYNFRTNYKRHKEITRYIENLTFNINTASKDTLLNFPMPLVLIELDGTIIWYNSS FKKIFDGEKLLEKTIHSFIKELNPDELSNGNVNFSKDIVINGRNYCVLGNFVKVDSKI NEDGFIILMYFVDNTELVELRKKYENERATVGIIIIDNYDDLMQSLEDTIRTQILAEI DAKITRWMGYTNGILKKFERDKYILIFDYKYLKDFEEKKFDILDSVKEINVGNKIPVT LSIGIGVGTDSLLEKFRFARASLDIALGRGGDQVVVKNGENISFFGGKTRELEKRTKV KARVIAYALRELIDQASDVMIMGHENCDIDCLGAALGIYRVAKNRNKEAHIVLNSSNP TIDVLISKIEKSGDYEGLFIAKEEAIEKISKKTLLIIVDTHRPSFTEFPELLKYTDQI VVIDHHRRGADYLQEAVLTYQETYASSTCELVTEILQYVEEKIKLAPVEAEALYAGIV VDTKNFTFKTGVRTFEAAAFLRRHGVDTVSVRQMFQSDINTYINISNVVREAEIVRDN VAISVCPQNVKNATLIAAQAADQLVNLAGLNAAFVLSHINSGVAISGRSLGDVNVQVI LEKLGGGGHMTVAGAQLQGVTVEEAKAKLVGAIDEYFVEINRQNA" misc_feature 33059..34879 /locus_tag="ClothDRAFT_2074" /note="Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887" /db_xref="CDD:33676" misc_feature 33404..33823 /locus_tag="ClothDRAFT_2074" /note="Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967" /db_xref="CDD:164309" misc_feature 33920..34408 /locus_tag="ClothDRAFT_2074" /note="DHH family; Region: DHH; pfam01368" /db_xref="CDD:144819" misc_feature 34679..34843 /locus_tag="ClothDRAFT_2074" /note="DHHA1 domain; Region: DHHA1; pfam02272" /db_xref="CDD:145431" gene 34941..35387 /locus_tag="ClothDRAFT_2075" CDS 34941..35387 /locus_tag="ClothDRAFT_2075" /inference="protein motif:TFAM:TIGR00158" /note="TIGRFAM: ribosomal protein L9; PFAM: ribosomal protein L9; KEGG: abu:Abu_0970 50S ribosomal protein L9" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="ZP_05430214.1" /db_xref="GI:256005247" /db_xref="InterPro:IPR000244" /translation="MKVILKEDVKGLGKKESLVEVSDGYARNFLIPKGLAVEATAANI NIMQTKKEAEKNRKERELAQAKELAEKLKGIVVTLKAKAGENGKLFGSMTSKDVSDYL KKQHNLDIDKKKISLPESMKSLGTYEAEVKLYPGVSAKLTVKIEQE" misc_feature 34941..35384 /locus_tag="ClothDRAFT_2075" /note="50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137" /db_xref="CDD:178893" misc_feature 34941..35081 /locus_tag="ClothDRAFT_2075" /note="Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281" /db_xref="CDD:144760" misc_feature 35124..35384 /locus_tag="ClothDRAFT_2075" /note="Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948" /db_xref="CDD:146531" gene 35441..36778 /locus_tag="ClothDRAFT_2076" CDS 35441..36778 /locus_tag="ClothDRAFT_2076" /inference="protein motif:TFAM:TIGR00665" /note="TIGRFAM: replicative DNA helicase; PFAM: DnaB domain protein helicase domain protein; KEGG: sat:SYN_00640 replicative DNA helicase" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="ZP_05430215.1" /db_xref="GI:256005248" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /translation="MDLGSFGRIPPQNIEAEQSVLGAILLDKEVLSSVTEIISSQDFY REDHREIFEAIMDLYEKGEPIDLITVAEQLKVRGSLEAVGGLEYLTNLASLVPTTANA KHYAKIVEEKSILRRLIKASSEIINMGYEAAEEVSYVLDKAEKSIFDVLQKRNTQGFA LIKDVLIDTFNRLEELYNNKGYITGIPTGFVDLDYKTAGLQNSDLILIAARPAMGKTS FVLNIAQYAAIHAKVPVAIFSLEMSKEQLVNRMLCCEAMVDSQKMRTGKLEDSDWQKV ARALGPLSEAPIYIDDTPGLSVAEIRAKCRRLKLEKNLGLVVIDYLQLMQGRGKSESR QQEISEISRSLKILAKEINVPVLTLSQLSRAPELRSDHRPILSDLRESGAIEQDADIV MFLYRDDYYNPDTEKKNIAEVIIAKHRNGSTGTVELAWLGQYTKFANLEKYRQ" misc_feature 35465..36766 /locus_tag="ClothDRAFT_2076" /note="replicative DNA helicase; Region: DnaB; TIGR00665" /db_xref="CDD:161985" misc_feature 35465..35773 /locus_tag="ClothDRAFT_2076" /note="DnaB-like helicase N terminal domain; Region: DnaB; pfam00772" /db_xref="CDD:144390" misc_feature 36014..36730 /locus_tag="ClothDRAFT_2076" /note="DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984" /db_xref="CDD:29985" misc_feature 36071..36091 /locus_tag="ClothDRAFT_2076" /note="Walker A motif; other site" /db_xref="CDD:29985" misc_feature order(36086..36091,36398..36400,36521..36523,36629..36631, 36695..36697,36728..36730) /locus_tag="ClothDRAFT_2076" /note="ATP binding site; other site" /db_xref="CDD:29985" misc_feature 36389..36400 /locus_tag="ClothDRAFT_2076" /note="Walker B motif; other site" /db_xref="CDD:29985" misc_feature order(36413..36418,36437..36445,36518..36544,36626..36631, 36665..36670) /locus_tag="ClothDRAFT_2076" /note="DNA binding loops" /db_xref="CDD:29985" gene 36794..38206 /locus_tag="ClothDRAFT_2077" CDS 36794..38206 /locus_tag="ClothDRAFT_2077" /inference="protein motif:TFAM:TIGR02432" /note="TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein; KEGG: sat:SYN_02776 tRNA(Ile)-lysidine synthetase" /codon_start=1 /transl_table=11 /product="tRNA(Ile)-lysidine synthetase" /protein_id="ZP_05430216.1" /db_xref="GI:256005249" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /translation="MIDKVLETIKKYNMINNKDKIVVGVSGGPDSVCLLHILCKLRES MDLGLVAVHVNHMLRGDEASGDEAFVENLCKKLNVELVTRRIDIKKLAKERRLSLEET GRIERYRLFEEVADNFGAQRIAVAHNKNDQAETVLMNIIRGTGLDGLRGMDYIRGRII RPLLGVERTEIENYCRIHNLNPRIDSTNLENIYTRNKIRLDLIPYIEKLFNADIVNGI SKMADLIKDDVSFIESRTDEIYNKAKIKSDDKGVILDLNILKECHIAARKRIIRNSIK QIKGDIKGIATVHIDSITDLIENGKTGSMLHLPHGVRAVKSYNTLKICLHELKEEDIY FNKEVNIPGITVVDEICGSLEATLIDVSADCFSIEDFTKVPDKSKVQFFDYDRLKEGI YLRNRRDGDVFRPRNSNGTKKLKEFFIDNKIPRETRNQIPLISTRKEIVWIIGYKISD KFKVTENTKIILKLSYDNSH" misc_feature 36803..37642 /locus_tag="ClothDRAFT_2077" /note="tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037" /db_xref="CDD:30386" misc_feature 36851..37405 /locus_tag="ClothDRAFT_2077" /note="N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992" /db_xref="CDD:30179" misc_feature order(36863..36871,36875..36886,36950..36952,36956..36958) /locus_tag="ClothDRAFT_2077" /note="Ligand Binding Site; other site" /db_xref="CDD:30179" misc_feature 37973..38185 /locus_tag="ClothDRAFT_2077" /note="B3/4 domain; Region: B3_4; cl11458" /db_xref="CDD:164228" gene 38360..38914 /locus_tag="ClothDRAFT_2078" CDS 38360..38914 /locus_tag="ClothDRAFT_2078" /EC_number="2.4.2.8" /inference="protein motif:TFAM:TIGR01203" /note="KEGG: pca:Pcar_2547 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase" /codon_start=1 /transl_table=11 /product="hypoxanthine phosphoribosyltransferase" /protein_id="ZP_05430217.1" /db_xref="GI:256005250" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /translation="MINQIKEILVTREELKNNAKELGKRISSDYEGKELVLIGVLKGG VVFFADLIREITIPIDVDFISVSSYGNSTKSSGVVRIIKDIDIDITNKHVLIVEDLVD TGLTLHYLKSMFEARGPKDVKICTALDKPSRRKVDLEIDYKGITIPDKFVVGYGLDYA EKYRNLPDVCVLDSSVYTDKEDMD" misc_feature 38381..38878 /locus_tag="ClothDRAFT_2078" /note="Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309" /db_xref="CDD:185893" gene 39042..40841 /locus_tag="ClothDRAFT_2079" CDS 39042..40841 /locus_tag="ClothDRAFT_2079" /EC_number="3.6.4.3" /inference="protein motif:TFAM:TIGR01241" /note="KEGG: gsu:GSU1809 cell division protein FtsH; TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: AAA ATPase central domain protein; peptidase M41; peptidase M41 FtsH extracellular; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase" /codon_start=1 /transl_table=11 /product="ATP-dependent metalloprotease FtsH" /protein_id="ZP_05430218.1" /db_xref="GI:256005251" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR011704" /translation="MKYFKNISFYIVLFVMLLAFLVIVQSRPVEKEQKYSQLISDIHN GKVQEIILEDNKATVKYKEEGQRDQFVYIPDVEVFMNEINDLIREGELEFRSKVPYSP PWWISILPTLVIIVVFVLFWVFFLQQSQGGGSRVMSFGKSRAKMTIDDKRKVTFNDVA GADEEKEELREIVEFLKNSKKFLELGARIPKGVLLVGPPGTGKTLLAKAVSGEAGVPF FSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRHRGAGLGGGHDER EQTLNQLLVEMDGFGANEGVIILAATNRPDILDPALLRPGRFDRRVVVGLPDIKGREE ILKVHAKGKPLAEDVKLDELAKSTPGFTGADLENLLNEAALLAARANKKVITMAEIKE ATFKVVMGPEKKSRVMSEKEKRLTAYHEAGHAIAIKEVSTTDRVDRISIIPSGMAGGF TAHKPDEDKNYETKSHLIEKIIVALGGRAAEEIVLGEVSTGAYSDLKQANGIARSMIT KYGMSDTLGNLVFANESDEVFIGRDFVQTKNYSEEIAAQIDREVKKIIDSCYERIKNI LKENINKLHAVANALMEKEKLEGYEFEELYANA" sig_peptide 39042..39122 /locus_tag="ClothDRAFT_2079" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.583 at residue 27" misc_feature 39060..39338 /locus_tag="ClothDRAFT_2079" /note="FtsH Extracellular; Region: FtsH_ext; pfam06480" /db_xref="CDD:148219" misc_feature 39420..40787 /locus_tag="ClothDRAFT_2079" /note="ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241" /db_xref="CDD:162266" misc_feature 39519..40019 /locus_tag="ClothDRAFT_2079" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009" /db_xref="CDD:99707" misc_feature 39630..39653 /locus_tag="ClothDRAFT_2079" /note="Walker A motif; other site" /db_xref="CDD:99707" misc_feature order(39633..39656,39807..39809,39948..39950) /locus_tag="ClothDRAFT_2079" /note="ATP binding site; other site" /db_xref="CDD:99707" misc_feature 39795..39812 /locus_tag="ClothDRAFT_2079" /note="Walker B motif; other site" /db_xref="CDD:99707" misc_feature 39990..39992 /locus_tag="ClothDRAFT_2079" /note="arginine finger; other site" /db_xref="CDD:99707" misc_feature 40257..40787 /locus_tag="ClothDRAFT_2079" /note="Peptidase family M41; Region: Peptidase_M41; pfam01434" /db_xref="CDD:144872" gene 41009..41413 /locus_tag="ClothDRAFT_2080" CDS 41009..41413 /locus_tag="ClothDRAFT_2080" /inference="similar to AA sequence:KEGG:Sfum_3560" /note="KEGG: sfu:Sfum_3560 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430219.1" /db_xref="GI:256005252" /translation="MENVNLKVGLNASVETWVSQKSTAEEYGSGNMDVYATPAMIGLM ERAALSAVALHLPKGYTTVGTAVNIKHIAGTPVGMKVKALAELIAVEGRKLTFKVEAF DGVEKIGEGYHERYIVSSQNFRDKVYKKAENI" misc_feature 41024..41404 /locus_tag="ClothDRAFT_2080" /note="The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509" /db_xref="CDD:186045" gene 41764..42957 /locus_tag="ClothDRAFT_2081" CDS 41764..42957 /locus_tag="ClothDRAFT_2081" /EC_number="2.5.1.6" /inference="protein motif:TFAM:TIGR01034" /note="KEGG: geo:Geob_1656 methionine adenosyltransferase; TIGRFAM: S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="ZP_05430220.1" /db_xref="GI:256005253" /db_xref="InterPro:IPR002133" /translation="MARKLFTSESVTEGHPDKICDQISDAVLDAIFSQDPMARVACET AVTTGLVLVTGEITTNCYVDIPKIVRSTIREIGYDRAKYGFDCDTCAVLTSIDEQSPD IAMGVNKALEAKTGEMSDEEIEAIGAGDQGMMFGFACDETPELMPMPISLAHKLAMRL SQVRKNGTLNYLRPDGKSQVTVEYDGDKPVRVDTVLISTQHGPEVDYDTIKRDVIEHV IKPVIPAELLDSKTKYLVNPTGRFVIGGPQGDSGLTGRKIIVDTYGGYARHGGGAFSG KDPTKVDRSAAYAARYVAKNIVAAGLARKCEVQLAYAIGVARPVSVRVDTFGTGIIPE EKIESLVNKYFDLRPAGIIKTLDLRRPIYKQTAAYGHFGRTDIDLPWERTDKAEELRK EAQSL" misc_feature 41770..42945 /locus_tag="ClothDRAFT_2081" /note="S-adenosylmethionine synthetase; Validated; Region: PRK05250" /db_xref="CDD:179974" misc_feature 41776..42066 /locus_tag="ClothDRAFT_2081" /note="S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438" /db_xref="CDD:144142" misc_feature 42133..42489 /locus_tag="ClothDRAFT_2081" /note="S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772" /db_xref="CDD:145757" misc_feature 42493..42912 /locus_tag="ClothDRAFT_2081" /note="S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773" /db_xref="CDD:111646" gene 43213..43617 /locus_tag="ClothDRAFT_2082" CDS 43213..43617 /locus_tag="ClothDRAFT_2082" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: MRPL17; similar to S. cerevisiae MRPL17 (YNL252C) mitochondrial ribosome large subunit protein (human MRP-L46)" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430221.1" /db_xref="GI:256005254" /translation="MAEIIFEVATCVLAAYGLMVLIHQFLVYIKQHNKGYRNSQVKLV LIVRNQGETIEGVLRNVLPRDFIRKLMPGGKLHVLDMDSDDDTLDILRKLEKDYECLE VLRKSEKDALFRCFEEPENNDAVWEHAKRRNV" gene 43710..45941 /locus_tag="ClothDRAFT_2083" CDS 43710..45941 /locus_tag="ClothDRAFT_2083" /EC_number="3.1.11.5" /inference="protein motif:TFAM:TIGR01448" /note="KEGG: dvm:DvMF_1404 helicase, RecD/TraA family; TIGRFAM: helicase, RecD/TraA family; SMART: AAA ATPase" /codon_start=1 /transl_table=11 /product="helicase, RecD/TraA family" /protein_id="ZP_05430222.1" /db_xref="GI:256005255" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /translation="MVTIEGTVEEIIFSNEANGYTVCEIKCDKEVITVVGYMPFINVG ETLRVSGKWVIHPDYGEQLKVELYEKLLPETPEAIERYLASGLIKGVGPATAKKIVKK FADQTLHIISHHPQRLAEIKGITMEKALRIGQAFEEQRGLRDVVLFLQEYGISPTYCA KIYKTFGPDTIEEIRKNPYRLSDEIFGISFRTADRIAKSLGIDPYSKYRISSGIKYVL SRAATEGHTFLEEEMLKSYTSKLLDINIDSIEDALVSLVLNKSVYVDRNDGMSKIYLS SFYHAELGVCRKLVELSQVRYSADMEDFEERIKQVQKKEGIILADKQKEAIREAMTNG VLVITGGPGTGKTTIIKSIISLLESEGYEFALAAPTGRAAKRMSEATGYEAKTIHRLL EIGYTSNEDELVFMRTEDNPIEADVVIIDEMSMVDIILMYHLLKAIVCGTRLILVGDV DQLPSVGPGNVLRDIIKSGMIKTVKLSEIFRQAGESMIVVNAHRINRGEHPILNEREK DFFFVTRNSQNDILKTVVDLCTRRIPDTYGYDPMKQIQVLTPMRKGTVGVANLNIELQ KVLNPEDGKKKQKAFRNYVFREGDRVMQIKNNYNLRWEKINGPGQEGAGVFNGDMGII VEIDDEEQKIKVLFDDEKLVEYDYTILDELEPAYAVTIHKSQGSEFPVVILPVFPGPS VLMTRNLLYTAITRARELVILVGNKDCLYGMIMNDRETKRNSDLAEKLRKCIVGVDWL KQW" misc_feature 43719..45899 /locus_tag="ClothDRAFT_2083" /note="RecD/TraA family; Region: recD_rel; TIGR01448" /db_xref="CDD:162366" gene 45935..46597 /locus_tag="ClothDRAFT_2084" CDS 45935..46597 /locus_tag="ClothDRAFT_2084" /inference="protein motif:PFAM:PF00156" /note="PFAM: phosphoribosyltransferase; KEGG: pca:Pcar_2573 amidophosphoribosyltransferase" /codon_start=1 /transl_table=11 /product="phosphoribosyltransferase" /protein_id="ZP_05430223.1" /db_xref="GI:256005256" /db_xref="InterPro:IPR000836" /translation="MVNWIINLIFPPKCIFCGTILGTNTKIEICKECYEKIDFKEGAS ISFQGQYNYYDSVVCVCDYSGIVKEAIRKYKFYNKPSYYRTFARLLAQKIKELIQWQK FDMIVSVPLHPERERSRGYNQSYLIARELGRELGIKNEAKVLKRVRNTYSQSLLKKED RLVNVKDAFRITDRSKVEGKAMFLVDDILTTGTTLNECSRVLKEAGAKKIVVAVIASG RR" misc_feature <46100..46552 /locus_tag="ClothDRAFT_2084" /note="Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309" /db_xref="CDD:185893" gene 46702..47145 /locus_tag="ClothDRAFT_2085" CDS 46702..47145 /locus_tag="ClothDRAFT_2085" /inference="protein motif:PFAM:PF00376" /note="PFAM: regulatory protein MerR" /codon_start=1 /transl_table=11 /product="regulatory protein MerR" /protein_id="ZP_05430224.1" /db_xref="GI:256005257" /db_xref="InterPro:IPR000551" /translation="MPDIRNCKRCGRLFNYIGGRPICQDCKKQDEEEFKRVKEYLYEH PKASIIEVSNALDISVQKIKSYLREGRLEIVGTEGNVVLECEKCGKSINTGRFCNECS RELTEGFKATAQEISKSVSGDTDKKKTSGMGMKYLNRYERWNSDK" misc_feature 46708..47088 /locus_tag="ClothDRAFT_2085" /note="flagellar operon protein TIGR03826; Region: YvyF" /db_xref="CDD:163538" gene 47378..47671 /locus_tag="ClothDRAFT_2086" CDS 47378..47671 /locus_tag="ClothDRAFT_2086" /inference="protein motif:PFAM:PF04316" /note="PFAM: Anti-sigma-28 factor FlgM family protein; KEGG: dal:Dalk_0624 anti-sigma-28 factor, FlgM" /codon_start=1 /transl_table=11 /product="anti-sigma-28 factor, FlgM" /protein_id="ZP_05430225.1" /db_xref="GI:256005258" /db_xref="InterPro:IPR007412" /translation="MKIWEGVPKVSGIYDSGKNVNKAEKTDGVTGKKDVVSISNQAKD FQTAMKALKEIPDIRKDKVEELARKIESGTYKVSEEDIADKILKSILDRKTQG" misc_feature 47477..47647 /locus_tag="ClothDRAFT_2086" /note="Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052" /db_xref="CDD:186310" gene 47785..48285 /locus_tag="ClothDRAFT_2087" CDS 47785..48285 /locus_tag="ClothDRAFT_2087" /inference="protein motif:PFAM:PF05130" /note="PFAM: FlgN family protein; KEGG: sat:SYN_02813 putative cytoplasmic protein" /codon_start=1 /transl_table=11 /product="FlgN family protein" /protein_id="ZP_05430226.1" /db_xref="GI:256005259" /db_xref="InterPro:IPR007809" /translation="MNDRLINDLMDVLLQESKIYEDILEISKKKTDVIVKGKVSELES ITNLEQSLIVKIGKLEETRENIVTEIAGIAGMDPSEMTISELEKHVDEKQAEKLREYK KHMTSIIEEIKNINEVNSRLIKNSIDFIDFSINILTSANLGGNNYSKEGQINENGKKG YFDVKL" misc_feature 47806..48249 /locus_tag="ClothDRAFT_2087" /note="FlgN protein; Region: FlgN; cl09176" /db_xref="CDD:186847" gene 48305..49774 /locus_tag="ClothDRAFT_2088" CDS 48305..49774 /locus_tag="ClothDRAFT_2088" /inference="protein motif:TFAM:TIGR02492" /note="TIGRFAM: flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; flagellar basal body rod protein; KEGG: bba:Bd0540 FlgK, flagellar hook-associated protein" /codon_start=1 /transl_table=11 /product="flagellar hook-associated protein FlgK" /protein_id="ZP_05430227.1" /db_xref="GI:256005260" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /translation="MGFAGLEIARSGMYVNERALSVTGHNVANVNTKGYARQQAMITT GPYLNLMRYQIGLGASIQETRQIRHLFLDNIYRNENTELGYWETRSKTFQEIQTILGD PMGDGLQNVLNQFWNAWQELSKEPDSLTVRALVRQRAEALVHQINHLGAQLDKLQEDL NQQIVLTIKQINDITKQIAELNIKIMQEEVCGDNANDYRDQRNLLLDELSKLADFEFT EMQNGDVQVTLGGYILVTKGEQINLVAGKSDINKMFFVPKIEGENIEVPVKSGVLRGL LESRGDVSGSIEGITDPAANPVPASANIVSDLKMRLNVLVNSLVTQVNNLHRSGKTLG NPPSDGEDFFVAINPAYPLEMGNIKLNDNLADLDNIVASKSGASGDNTIALAIANLRD NRVIADVSGMVSLDDYYQTIILIVGTGGSEAEKTAENQRTLVNSAEAQRQSIMGVSMD EEMSNMMRYKFAYSASSRAINVIDDMLETIITRMGLVGR" misc_feature 48311..49771 /locus_tag="ClothDRAFT_2088" /note="flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739" /db_xref="CDD:181099" misc_feature 49640..49753 /locus_tag="ClothDRAFT_2088" /note="Domain of unknown function (DUF1078); Region: DUF1078; pfam06429" /db_xref="CDD:148188" gene 49781..51340 /locus_tag="ClothDRAFT_2089" CDS 49781..51340 /locus_tag="ClothDRAFT_2089" /inference="protein motif:TFAM:TIGR02492" /note="TIGRFAM: flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; flagellar basal body rod protein; KEGG: bba:Bd0540 FlgK, flagellar hook-associated protein" /codon_start=1 /transl_table=11 /product="flagellar hook-associated protein FlgK" /protein_id="ZP_05430228.1" /db_xref="GI:256005261" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /translation="MSSFFGFNVAVKGLFTAQRNMDIINHNINNVNTPGYSRQVAIQS ASNPISLLNGTGMLGTGSEVLAIERIRDEYLDYKYWSENISYGEWNAKRTLLADMEVT FNEPSDSGFNAVINSFYNSLQELAKDPSSDAIRALVKEQGVTFARYFNNIASHFEELQ FDINNQVKTVVTEINSLGTQIAQLNKQIYTAELDGNTANDLRDKRTLLIDELSKLVNI DVNEVVVGKLPNGKDDKRMIITISGKAFVDNFDVNKLTIKQRENKLNEEEDIPNLYEV LWEDGNSLSVRGGELKGLLDVRDGNDGENGSPNYKGIPYYIRKLNEFVRTFAIAFNEG IVGNDKVAGHVDGYGTNGNTGIRFFTILGEENKPISSADFMSAGDIDACYGKMTAKNF TVSSDILDDPRNIATADTKDQVGNIGNINSILAMRNNVHMFKEGAPEDFVKSVITTLA IDSQQTIRLSSIHKNMIEQVENQRMSVSGVSLDEEVANLVKHHQAYAAAAQMINTMAE VYDILINRVGL" misc_feature 49781..51337 /locus_tag="ClothDRAFT_2089" /note="flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739" /db_xref="CDD:181099" misc_feature 49799..49888 /locus_tag="ClothDRAFT_2089" /note="Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460" /db_xref="CDD:109515" misc_feature 51212..51328 /locus_tag="ClothDRAFT_2089" /note="Domain of unknown function (DUF1078); Region: DUF1078; pfam06429" /db_xref="CDD:148188" gene 51381..52289 /locus_tag="ClothDRAFT_2090" CDS 51381..52289 /locus_tag="ClothDRAFT_2090" /inference="protein motif:TFAM:TIGR02550" /note="TIGRFAM: flagellar hook-associated protein 3; PFAM: flagellin domain protein; KEGG: gur:Gura_4098 flagellar hook-associated protein 3" /codon_start=1 /transl_table=11 /product="flagellar hook-associated protein 3" /protein_id="ZP_05430229.1" /db_xref="GI:256005262" /db_xref="InterPro:IPR001492" /db_xref="InterPro:IPR013384" /translation="MRITNNMIVNNMINNIGKNLARMDKYQQMLATGKKITVPSDDPV VAARALKLRTDVAQIEQYKTNVQDAMSWLEITESAVANVGDILQRARELAVQASSGTT TEEDTKKIKQEVEQLKNQLIKIANSTYAGRYIFSGFKTNTRLMDDDGYFTMDVANSEA IIYQIGISDSININVPGGDLFNGGIDAGAGGKGKLIADFEAYINALDSGDHSLISDAI TNIDENLNHVLRIRADIGARYNRLELTADRLDIDSINFRKLMSENEDVDQAENILLLK TEENVYRASLSGGARIIQTSLVDFLK" misc_feature 51438..52286 /locus_tag="ClothDRAFT_2090" /note="flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701" /db_xref="CDD:181087" misc_feature 51441..51800 /locus_tag="ClothDRAFT_2090" /note="Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669" /db_xref="CDD:144315" misc_feature 52032..52283 /locus_tag="ClothDRAFT_2090" /note="Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700" /db_xref="CDD:144340" gene 52333..52911 /locus_tag="ClothDRAFT_2091" CDS 52333..52911 /locus_tag="ClothDRAFT_2091" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430230.1" /db_xref="GI:256005263" /translation="MGIIITQTHARIGIDRTYSKMEIETQNARFKLHQNHAKVEIETE LPKIEIDQYEAFASAGLKNHLDLAREIAQKGRQNALRYIGKVADDGDALAAIENGGNL IPELAKRDSYKTHEFNIDAIPKASPKVSVSGGLEIDFPQDYRRIIHNGVEGIFIPPYF DLKYTPEKIKIYLEQYASIKIDYVENKIDTYV" gene 52941..53420 /locus_tag="ClothDRAFT_2092" CDS 52941..53420 /locus_tag="ClothDRAFT_2092" /inference="protein motif:PFAM:PF02623" /note="PFAM: protein of unknown function DUF180; KEGG: sat:SYN_02809 transmembrane protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF180" /protein_id="ZP_05430231.1" /db_xref="GI:256005264" /db_xref="InterPro:IPR003775" /translation="MLLKTKHFGEINIDESKIIEFKDGIPGFENLKRYVVLYDGDKNS PFRWLQNVDDGELAFAVVNPFMVVKDYDFEIPDEAVESLGIESILDVMVLSIVVVPED ISKMTMNLKAPVIINTKNNKGMQVVLDTDRYSVRHYIIEELRRQEVNVGAGSDEKEK" misc_feature 52941..53387 /locus_tag="ClothDRAFT_2092" /note="FliW protein; Region: FliW; cl00740" /db_xref="CDD:186170" gene 53392..53619 /locus_tag="ClothDRAFT_2093" CDS 53392..53619 /locus_tag="ClothDRAFT_2093" /inference="protein motif:TFAM:TIGR00202" /note="TIGRFAM: carbon storage regulator; PFAM: carbon storage regulator; KEGG: sat:SYN_02810 carbon storage regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator, CsrA" /protein_id="ZP_05430232.1" /db_xref="GI:256005265" /db_xref="InterPro:IPR003751" /translation="MLVLTRKKNESIIINDNIEITVVDVQGEQVRIGINAPKSISIYR KEIYLEIQAENKKAAEIKNVDLKEDLKDFLK" misc_feature 53392..53580 /locus_tag="ClothDRAFT_2093" /note="Global regulator protein family; Region: CsrA; cl00670" /db_xref="CDD:186136" gene 53831..>54624 /locus_tag="ClothDRAFT_2094" CDS 53831..>54624 /locus_tag="ClothDRAFT_2094" /inference="protein motif:PFAM:PF00171" /note="PFAM: Aldehyde Dehydrogenase; KEGG: mxa:MXAN_0626 aldehyde dehydrogenase family protein" /codon_start=1 /transl_table=11 /product="Aldehyde Dehydrogenase" /protein_id="ZP_05430233.1" /db_xref="GI:256005266" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /translation="MAENHDYEREINRLFELQKKNVVRLRTSSIDERIAKLKKLKEYI WENKEKIQEAVYNDLRKPPEEVLLTEIYPVVSEIRHVIKNLKKWTKPKKVRTPISLFG AKSYYRFEAKGVVLIISPWNYPFELSIGPLITAIAAGNAVVLKPSELSPHTSGYIKKL VADIFDESEVAVVEGDAVVAQKLLEMGFNHIFFTGSTKVAKAVLKKASETLSSVTLEL GGKSPVIIDGKFDIEEAAKKITWGKYLNAGQTCIAPDYVFVKKELLG" misc_feature 53864..>54619 /locus_tag="ClothDRAFT_2094" /note="NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961" /db_xref="CDD:187156" misc_feature order(54182..54196,54218..54220,54263..54265,54269..54274, 54407..54418,54425..54427,54434..54439,54479..54487, 54581..54583) /locus_tag="ClothDRAFT_2094" /note="NAD(P) binding site; other site" /db_xref="CDD:143395" misc_feature order(54194..54196,54479..54481,54572..54574,54581..54583) /locus_tag="ClothDRAFT_2094" /note="catalytic residues; other site" /db_xref="CDD:143395" ORIGIN 1 attaataaag tgaaaaatcg acatattaga aatactgagt tagtgtttat ataaacttta 61 aaaaccaagt tcgttgaagg attggtcggc aaagctagag agctggtgtg aaaacactat 121 gaaggttggg ccgcaagtag gaaataagtt accttaatca aatctccggc tcaattatgt 181 taacaaacca atggcatgca ggaggaaagc aatgattaag atggtacaat tagaggatat 241 cagaaaaatc tgattcatgc aaggtctgag tgccagaaaa atagaacaca ggagtagaat 301 atacggaaca taacttcaaa gtacattttt caggaggaac caaaaccgac gaaactaagt 361 caacataaaa atgcagacat ccggtactgg gaccattact gtaaaaaaaa taaagttctg 421 cttgaaagct taagaagttt acaaagtttc aaaaggttca agcggcaaaa cctgtaagtt 481 tcaggttttc caatcttgaa aacagaggaa agctttgact ttttggttct ttatgaatta 541 ttcgtcaatt acacctttca ggaaagttga gaccaaattg cttttctagg ttttgttcct 601 ccttcgattc caattcaaaa attgccctga tttttatact attcaaatgt taagcaaatt 661 ataacaaaat taacaatact tgttcaatac ttggaaggag gtgagtgatg atgaatgatc 721 ttttgaccag ccagtacgtg gcttatgaat tggcaggtga gaaatatgcg ttaaagatca 781 gtgatgtata tgaaattata aaaatgcaaa gtatcactcc aatacataac agcaaacctt 841 tcctggaagg ggttatcaac ctgcggggca aaatcattcc tgtggccaat cttcataaaa 901 gattcggtct tggcaattac actcatacca aaaaaacccg cattgttgtg gtgaaaagca 961 gagatgagat gattggaatt gtggttgata aagtgaacca ggttataagg ttttcagaca 1021 ttcaaccacc tccggagatg gtggcaggga ttgacggcag ttactttgaa ggtgtaggta 1081 tcactgacga aggagtgata agcattctga aaattgacaa agtacttcac gaataaggaa 1141 ggggtgcagc atggccagca tatttgaaag tccggagctg ataggggctt ttatcggcga 1201 agtggaagag cagctacaac ttctcgaaaa caacgttgta gagttggaga aaaacggtgg 1261 cacagcagag gtggtccagg aattattccg tgcggcacat accttgaaag gttcttctgc 1321 cactatgggt tttgaaaaga tgaaaactct tacccatgaa atggaaaatg ttctggataa 1381 aatacgcaat ggtcttctcg aaatatccag gcctgttatc gatgttcttt ttgagtgttt 1441 ggattgtttg aacatgctaa aggaagattt tgtttctgat tcaaacaacg tcaaaacaga 1501 gataactcct gtgataacca aattaaaaga gatatcatct gaaaatgaaa caaataacca 1561 aaacagtgat tcggacaaag ctgaaaattt agaaaccgga cgtcgggaac aaccgatatt 1621 tgtacttgat gaaaaacagc aggagcagat aaatcaggcg cttggcattg gccagaatgt 1681 tcttgtatgc gaggttgaga ttttggaaga cagccaaatg aaatcagttc gggcctgctt 1741 aataatgaac ttccttaatg agtggggaac agtcataaat atggttccca atgtgatgga 1801 aataccaata gattctgatg tcggcaaagt ggcttttttg gttgtcactc aaatgagtgc 1861 cgacgagttg cggcagaaag tacaaaatga cctgatggat attaaggaag tcagagtttt 1921 cccctatttt attcaaaatt caatatctca gacaaaggac ggagaaaccg gggtacggga 1981 taaagataat agcagcggcg tcaaaacggc gacagaggaa aaaagggttg tacatactgt 2041 aagaattgat gtggaccgtc ttgagaggat gatggacctg gtaggcgaac tggtgattga 2101 gcagatacgg attgcccagg ttgcaaacaa cttatataac caataccctt ctgacgaaac 2161 cgttgatgac ttgataggca tttcaaaccg tgtatcgata ttaatcaatg agcttcagga 2221 aggaattatg aaaacccgta tgataccggt acagcagttg ttcagccgtt ttccaagaat 2281 ggtcagggac ttgtccgtct cattgaataa agaagttaat ttagtgctgg aaggcgggga 2341 aactgaaata gacaggacca tcatggagga aatgagtgat ccgctaatcc accttatacg 2401 aaacgccata gaccacggga ttgaaaatcc ggaaattcgc aaaaagttgg gaaagcctga 2461 acaaggcaca ttacgggtga cagcgttgcc tgaggacagc aatgtaatta taacggttga 2521 agatgacgga gccggaattg accctcagga gataaaacag tcagccatta aaaagaggat 2581 tgttacagag caggaagcaa acaacatgac tgagcagcag ttaataaacc tcatttttca 2641 aacaggcttt tccacttccc agaaagtgag cgatgtttcc ggccgtgggg tgggaatgga 2701 tattgtaaaa acccatattg aaaaattgaa tggaatcatt gatgttgaga cttgtgcagg 2761 cagtgggaca aagttcataa tcaaactgcc aatcaagctt cccctcactc ttgcaatatt 2821 aaaagggctt ttggttaaaa tcagcaatga aacttatgct cttcctatga acaatgtggt 2881 tgaaattgta cgaaagccaa aaaatgaaat tgaatccatc aatgggcaag cagtggcagt 2941 tataagggac agagcgattc ctttaatatg gctgcatgac tatttcggca tcccacgggg 3001 taatgagagg aaaaatactc tgattgtttt gctgggaata gctgaaaaac gttttgggct 3061 tgtggtggat gagcttatag ggaaccagga aattgttgtc acaaaccttg gttcttatat 3121 aggcaaagtg gaaggtattt ccggagcaac aattttggga gacagaagtg tggcgtgcat 3181 actggacgtg gtagggattg cgaaaatagt gaacagcagg aaagtttcca ggatagatgt 3241 tgaatattca aaacagtgac tacttcaaaa acataaaata ggaggcattg tctatgggat 3301 tcaaaaaaga tgtggctctc aaatttgtga aaaattcgga actttctgag aaagtgtata 3361 aagcggctag ctctgccaaa aaactcgatg aaaggctaaa ggatttgtcc aatatcactg 3421 agcaggttgc aaaaggtgca aatgaacaat cttcagccgt tgattcaaca aactcaatga 3481 cggaaagact ttcacagtca attaacggtg ttgttaaaaa tgccgaaaag ctgaaggagc 3541 ttgccggaca gtccaaaaaa tcccttgaag atatggttgt tgtaataaag caagttgcag 3601 gaaatagtga aagtaccgca aagtcggtag aagaaatatc tgtctccatt gagcagatgg 3661 gaaaatcagt caaaggtgtt gccggtaatg ctgaaagcct gacgcgttct gccgaagaaa 3721 tgtcggcggc catacaggag atagtcggct ccattcaaca ggtggcaggt aatgccgaaa 3781 gtactgcaag ttctgttgag caaatttcat cttctattga acagatgggc aaatcaataa 3841 agggtgtggc aggaaatgcc gagagtctta ccggttcagc cagagaagct acagcggcgg 3901 ttcaggaaat ggccgcttcc atccagcagg tagcgggaaa cagtgaaagt accgcaaact 3961 ccatagaaca aatatcgtct tccatagagc agatgggaag atctatcaat ggagttgccg 4021 taaatgcgga gagtctttca aattcggcgg cggaagcaac aaatgccatt cattcaatcg 4081 ttgcgtcaat ccaacaggta gcgggaaatg ccgaaagtac tgcaagctcc atagagcaga 4141 tatcatcttc catagagcaa atgggtaaat ccatcaaagg agtggcaggc aatgctgaaa 4201 gtatgtcagg atcggcacag gaagcatcag cagcgataca ggagattgta gcgtcaatcc 4261 agcaggtggc gggaaacagc gaaagcacat caagctccgt agaacaaata tcatcttcca 4321 tagagcaaat gggtaaatcc atcaaaggag tggcaggaaa cgccgaaagt ctgaaaggtt 4381 cggctgatga agcgacggcg gcgatacagg agatagttgc gtccattcaa caagtggcag 4441 gcaacgcgga aagtactgca agctctgtag agcagatttc atcgtctatt gaacagatga 4501 gtaagtccat caaaggtgtg gcaggtaatg ctgaaagttt gacgggttcg gcggaagaag 4561 cgtcagcagc ggtgcagaaa ataataagtt ccatccagca ggtggcagga aacagcgaaa 4621 gtacggccaa atcggttgaa gaaatcgctt tgtctattga aaaaatgggc aaatccatac 4681 agggagtagc cgcaaacgcc gagagtttaa aaggttcggc agatgtatct gctgctgcga 4741 tacaggagat agttgcgtcc atccagcagg tggcaggtaa cgcagagagc acggcaagtt 4801 ctgtggagca aatatcatct tccatagagc aaatgggaaa atccataaaa ggtgttgcag 4861 gcaatgccga cagcctaaag ggttcggcag acgaatccgc tgctgcaata caggaaatgg 4921 tggcatccat ccaacaggta tcggacaatg ctgaaagcac agcaagttcc atagagcaaa 4981 tatcctcttc catagaacag atgggtaagt ccatcaaagg tgtggcaggc aatgcagaaa 5041 acctgaaagt ttctgctgac gaggcgtcgg cggcaataca ggaaattgtg gcttccattc 5101 agcaggtggc cggcaatgcg gaaagtacag cccagtcggt tgaagaaata tcttcttcga 5161 tagaagaaat gggcaaatca atccaaggtg ttgccggaaa tgccgaacag cttcaaaaat 5221 ccgcccatga aacatcccaa gtggttgaaa acatggcggc ttctataagc caggttgccc 5281 agaatgcgca gaatgtaaat aagttaagtg aaaaagtgag aagtgatgcc atagagggtc 5341 aaaaggcagt ggctgacaca ttggtggcta ttaaagacat atcggaagtt attcatcgtg 5401 cggaggatgt tataaatggc cttgggaaga gctccgaaaa aataggcagt atcatcgaag 5461 tcattgatga tattgccgag cagacaaatc ttcttgcact gaacgcggcc attgaggctg 5521 caagggccgg agaacacggc aagggatttg cggttgttgc cgacgaggtg agaaagctgg 5581 ctgaacggac tgctacggca acaaaggaaa tatctgaact cataaaaggt attcaggggg 5641 aaacaagtca ggccatcaag gctatagaag ttggtactca aaaggtcgaa catggttcaa 5701 agttaagtga cgaggcgggc aaagccattg aaaagatagt tgagggaata gaaaatgtaa 5761 atatggaaat ccgtcagata actgccgcca ccgaagaaca gaacaagggc agcatgaaga 5821 ttattgaagc tgtgaacatg gtgacaaatc aagcatcgca ggtaacccag gctaccaaag 5881 aacaggcggc gagtgtggaa aacatagtaa aaggagtagc caatgcgagg gagcaggtaa 5941 gacaggtcac tgtggcggta aaggaacagg caaaacaggg tcaaaatatt ataactgccg 6001 tagaaaatgt gaacaatcaa gcggcacagg taacccaggc taccaaagaa cagacaaaag 6061 gtgctgaaga aatcattaaa ggtgtggcaa atgccagaga acaggtacgg caggttactg 6121 ttgcggtgaa agagcaagcg aaacaaggcc aaaatattat acagtccatt gaaaatgtca 6181 cacagcaaac agctcaggtt gccgctgccg taaaagaaca gactgtcggt gttgaggaaa 6241 taataaaagg tgtggccaat gcccgcgagc aaataagaca ggttacggca gcgatgaaag 6301 aacaggcaaa acaaagccag accatagtgg ttgctgtgga aaatgtgacc aaacaggctg 6361 cagaggttac tcaggcaacc aaagagcagg ctaaagatgt tgaagacata ataaaaggca 6421 tagaaaatgc aagagaacag atgagacagg ttaccgttgc agtgaaggaa caggcggaac 6481 agggtcagaa catagtaacg gcggtagaga atgtgacaag acaggcagca caggtgacgg 6541 atgtaaccaa agaacaggca aaggccgttg aggatattgt aaagggtatt gaaaactcca 6601 gagaacaggt aagacaaata tcggctgcgg tggcagaaca ggcaaaacaa ggacagaata 6661 ttgtagctgc agtggaaaat gtgaacaaac aagcggcgca ggtggcacag gccgccaggg 6721 agcaaaccca aggtgttgag gaaatcatca aaggtgtggc aaatgccagg gaacaggtaa 6781 gacagatttc ggcagcagta aaggaacagg caaagcaggg acaaaatatt gtgattgcgg 6841 tggaaaatgt aaccaatcag gcatcgcagg taacccaggc agccaaagag caggctcaag 6901 gagtcgaaca aattatcaag ggtgtggtaa atgcccggga acaggtaaaa caggttactg 6961 ctgcagtaaa agagcaggct ttgcagggac aaattgtcat taaagccgtg gagaatgtca 7021 ccaaccaggc tgctcaggtt acacaggctg taaaagaaca ggcggcagga gctgaggaaa 7081 ttatcaggaa cgttgcaaat gcgagagaac aggtacgcca gattactgtt gccgtcaaag 7141 aacaagccag gcagggacaa gacattactg catctgtcca aaatgtcacc gaccaggcgg 7201 cacttgtgtc aaatgcagta aaagagcaga ctcaaggtgt tgaagacata ataaaaggca 7261 ttgataatgc aagagagcag atgcgtcagg ttaccgccac agtaaaagag caggctaaac 7321 agggacaaaa tatagttacc gccgttgaaa atgttgcgag ccaggcagct cagattacaa 7381 atgtgacaaa agaacaggcc aatggtgtcg agaatataat tagaagtgtt gcaaatgccc 7441 gtgaacaggt aaaacagatt acggcagcca tgaaggaaca ggcagtaaat gcggacaggg 7501 ttattaataa cgttgaaggt gtaagcattc aggcatatga agtggctgac gctgccaaag 7561 ttcaggcaaa tgaggtggaa cagctggcta aatacacatc cgaaatagat cgtgttataa 7621 acctcaatat caaggatgtt gagcgtactt gtgcggtgac aaaagaattg tcggaatact 7681 cggaagatat tatggatgca ttacaggaac tggcaaaata gtgtttcaaa tttcccataa 7741 acaaagcctt attacgcctg aagctaaaaa aatgaactcc cattttccca tagttaagat 7801 aagcagcttt aaccattatt gtttgtattg gagaggcatt atgcctctcc acagattgta 7861 ttagggaggc tggaacaaat ttatatggat acattcggac tgattcaatt ggcagagctt 7921 atatatgaat attgcggcat tgactttttt aaaaaccttt cctctcttga aagcaaaata 7981 tccgagaggc tcaaagaact gggtctttcg tgctgggaat acgggggtta tttaagagtt 8041 gaaccaaaag agtgggacac gcttattgac cttattacag taaatgagac ctattttttt 8101 cgtgaggaaa atcttttgga agaatttcaa aaggttatac ttccaaagta caaggaccgt 8161 acaccaaaca atcctttacg catatggagc tcagcctgtt ccagcggaga agagccgtat 8221 actttggcaa tattaagtga agagaccgga ttgtttgaaa ctggcgcagt tgagattatt 8281 gcttctgata tagataaaaa agttttggaa aaagcaagac ggggattgta taataaaaaa 8341 tcattttcct ttcgcacaat gccaaaagaa atacttgaca aatattttat ttcatttgga 8401 gatgattata aggttaagga ttcaataagg gctatggtgg attttcgccg tgtgaatctt 8461 ctggatgaaa atatattgga aagggttgga gaggtggata tagttttttg cagaaatgta 8521 ttgatttatt ttgatacaaa agcaataaat aaagttatta attctttgta caaagtgtta 8581 agagcacgag gatacttgtt tttaggccat gcagagacca taacgggaat gaataccgga 8641 tttgagacaa tatatacacc ttcggcattt tattatcgga aaggagaaag gcattgatgc 8701 agcagtatgg agtattagtg gtggatgact catcttttat gcgaagatgt ataagcttga 8761 taatagaaaa ggatcctcag ctttttgtta taggaattgc aagaagcggt gttgaagcga 8821 tagaaaaagt acacaggctc aaaccagaca ttgtgacaat ggatgtggag atgcctgaaa 8881 tggacggtat gactgcctta aaggagatta tgaggacttg tccggttcct gttgtaatgt 8941 tgagtaaccg aaccgataag gacccaaagg cgacttttca ggctttggaa ttgggtgctg 9001 cagactttta tttaaaaagt gcattgctgc aagagaatgt gaaaccggaa ataataaagg 9061 agtttttgga taagttgaaa gctattgccc aaaaggcaag aaaaactgca gataaagaac 9121 gggaacagaa tactgcttct gaaaatatgt ccgagattct tgaaaacatt ttgaacaaac 9181 cggaaagttc cattgaaacg aagtccggat cggccgactt gttaataata gggtgctcca 9241 ccggagggcc ttccgcgttg cagtccattc ttccacgttt tcccaaagat acccatgtgc 9301 caattgttgt tctgcagcat atgcctccag ggtttacaaa gcctctggct gagcgttttg 9361 acgctatttg taatttacac gtcaaagaag ctgaagacgg tgatattctt gaggccggca 9421 atatttatat agctccggcc ggctaccaaa ccttccttga taaaaaagca gataatgtaa 9481 tagctttgag ggtggaagac tgtcctgctg ttgaaacgct ttacagaccg tctattaatg 9541 taacccttga ttctgcggcg cctatctata gagaacggtt gctgtcggtt atccttacgg 9601 gaatgggaaa tgacggactt atcggatgcg agaccgtcaa aaaatacaat gggaaggtaa 9661 ttgttgaggc agaggaatcc tgcgttgtat atggtatgcc gaaggtgatt tatgaagcag 9721 gacttgctga tgttcaagta cctttgtcaa acatttttca cgaaataatg cactatatct 9781 gaaatgaatg acaggcagtg ctatttataa tacctttgac aaaaattctc tggttcttgg 9841 attttgagga tttgagaaaa tttcctcagg ggtattgtcc tccagaatcc tgccgtcatc 9901 cataaacaaa actctggtgg ctacttccct tgcaaatccc atttcatgag ttacaataac 9961 cattgtcatt ccttcgtcag caagctgcct gataaggtca agaacttctc ctaccatttc 10021 ggggtcaagg gccgaagtgg gttcatcaaa cagaataact ttcggattca ttgcaagagc 10081 acgaattatt gctattcttt gcttctgtcc gcccgaaagg gttgacggat agacatccgc 10141 tttgtcttca agcccaattc ttttaagcag gcgcatggca ttttctcttg catctgcctt 10201 tattttttca cgggtggtat tgatttcata cagaggcttt ttttctttac tgaatatatt 10261 tcgaaacttt ataaagaaat ttttaaattt cattacgtta aggtcatgta tccctaaata 10321 taccggtgca agcattatat tttcaataac agttttatta ttaaacaggt tgaattgctg 10381 aaaaaccata cccatatgac gtcggtaaag gttgatgtca actctcatat ctgcaatatc 10441 cacaccttca aatataatgg atccgcttgt ggggtcttcc atgcagttga ggcaacgcag 10501 aaaggtgctt tttccgcttc cggacggacc tatgatggca actttttcac cttctttgat 10561 actgaccgtg atacctttta aaacttcaag gtctccgtag cttttcttta gattaattac 10621 gtctatcact ctttctgagc ctcctttcca ttacttttat gagagatgca attatcataa 10681 ccagtgcgat ataaataagc gccattgcaa ggtatggaac cataaattca taactgtttg 10741 tgcctatata actaaaagcg acatacaaat cggcagcacc gacaaaactt acaacggaag 10801 tttctttaat caaagctata aattcatttc ccagagtggg gagaatattt ttaacagcct 10861 gagggataac tattttgagc attgtgacgc ggtagctcag gcccagagcc cggcctgctt 10921 ccatctgacc gtggtctact gacatgatgc cgcttctcat tatttcagaa acataagcac 10981 cgctgttaag accaaatacc agcacgcaca cggtaagtgc ggacaaattt atgccaagaa 11041 ggggcaaaac tacataatag gccaccagga gctgcacaac aaccggtgtt cccctgaata 11101 gcccaacata aaaatcacat atcgcattta gtatcctggg taattttttg tatttgggca 11161 tcactttgac agtagcaatt aacgtaccaa tgataattcc tatcacaagt cccaaaattg 11221 caatgtaaag tgtattctta agcccttcaa gaactttgat ataacctttg ttattataaa 11281 aaatttccca gaacttaatc agttttctat caaaattccc cataattaaa ttcctttaaa 11341 tttttgattc ctttaagtta gttaagctca ttaattgctc ttactatgct gtcggcagga 11401 gcctcatcaa taatgacaaa gtcaatgttg ccgttgagca tgtcctgaac ggcaagagag 11461 cctgacttgt aacctacgca tttaacatta tagccctcaa aaccccagtc ttcatcgcct 11521 tcaacataga attggccggt tgtacctgtc tgaacaccga tttttgtatc actgcttaag 11581 cttgaaagaa ttgcttccac atcagcagcg gttttacagt tgtcaaatgt attgtcgtct 11641 tctctgacaa taagtttttg ggaagcatta taatatgtgt ccgagaatgt aacatactct 11701 ttcctgtcct cttttaccgt aagaccggac attgcaatgt cggcttttcc ctggcctacg 11761 gaaaggcaaa cggcatcaaa gtccatgttt ttgattacaa gctcttttcc gagatattct 11821 gcaagaagtg cggcaatttc catatcaata ccgtaatact cgctgcctcc gagagtatat 11881 tcaaaaggct caaacgccgc atttgtggca actacaagct ggtctttgct gctgtcttcc 11941 actgcagata taacaggttc aggttccccg tcactgaaat atttgtcgct tattttttga 12001 agggttccat cggacttgat ttgcgaaata aactcattta cctttgcaag cagttccggt 12061 tggtttttat caactccaaa agcatattcc tcctgggtta actgaatgtc aataactttg 12121 gcacgtttgg cgcctgaaac tttgctgtcc gaattgcaac ctgcgaggat aagactaaaa 12181 agcatcagca ttataacggt aaaaataaaa ctctttttca tacaaaattc tccttaaaat 12241 tttataaaac tataatttta tgtattcatt gttataaata taaattatcg tatctgagta 12301 tttttgtcaa cataaaatag ttattatttt aacaaaaaag tacaaatttt ttaaacaaaa 12361 caattttgct ttttatcttt tatattgcat attttggatt agatatacta taattttatt 12421 tgtttaattt aatttaacag cggcaatatc ttgaataatt atgcagtggc ttttataaaa 12481 aacaccgata aatgatttga gggatttccg gataagcaca aaaaatgagt gggaggatcc 12541 aatgagtgaa actgacggaa aagcatttta ttgttggcag tagtaaaaat ggctatattt 12601 tttcgtttat tataattctt gccttgttaa cgacatttac cgcttgttct gaaaactctg 12661 cggtaaatgt tgaaactgag tcttcatcaa agtcttcaaa aaagatttat ctttatggtg 12721 aaaagcacgg cgtaaaaaag ataatggata aagaatttga gttgtggcac gaatactata 12781 acaataaaaa tatgaggcat ttgtttgtcg aactacctta ttacaccgcg gagttcttga 12841 acatctggat gaaatcggac agtgatgaaa ttttagatga gctttacaat gattggattg 12901 gtactgcttt atataatcct tatactaaag agttttacaa gaagataaaa agtaactgtc 12961 ctgaaacaat tttccacggc acggatgtcg gtcatcaata cgatactacc ggtcaacgat 13021 ttttgaagta tcttgaagaa aataatttaa aagactcaga aaaatatagg ttggcgcatg 13081 aagcagtaaa acaaggtaaa tattattatg aaaactccga tgatgtatat cgtgaaaaca 13141 aaatggtgga aaattttata cgggaatatg atgcgttaaa tggggaatgt ataatgggca 13201 tttacggcaa cgcccatacc agcctggatg ccatggactt tactgattcc gtaccatgca 13261 tggccaatca gctgaaagat atttacaaag acattatcta ttcggaggat ttatcctggc 13321 ttgcaatgaa tccgtttgag agaatagtat attggctatt tgagaaaaaa taagagggat 13381 ttttgtccct cttttttggt tacttcaagg tatttattat tttcttttta ctcctactgt 13441 tgtaagatga catatctttt ttactgcctc gataaggtcg ctttccgtta tatcactgtg 13501 accttcgccg gtggcaatta ctgcggcttc attaagtatt gtttctatct gggaacaggt 13561 catgccttca aattttgcgg ccagttgttc aattgatatg ctttcggaca attttttgtt 13621 ttttgtatat atttttatca attcaattct ggttttataa tccgggttag gaacggtgta 13681 ttttttgtca aaccttcccg gacgcaccaa tgcttcatca agggccttgt aattgttggt 13741 tgcggcaata accataacac cgccttcacg ggtaaaacca tccatttcat ttagcattgc 13801 ggcaataatt ctgttgtttt ctttgtcaat tccggttccg gcataattgc gtttttcacc 13861 tattccatca aactcgtcta tgaatatgat gcagggcttg ttggcacggg cttttctaaa 13921 cagggcctta attttggcag gtcctatgga catgattgca ctttgaaaat ccgtggcctt 13981 ggtggcaatg aaattgactt tggcttctcc tgccaatgcc cttgcaaaca atgttttccc 14041 gtttccggga ttgccttcaa gcagaatacc gtttatcggg cgtattcctt ttgccgcata 14101 ctctttggga tgttttaaga tgtccacggc ctgaagcatt tctcttttta aatcttccat 14161 gccggcaaca tctgaaaatt ttgtgtcgtt gttgcgaata actttaaatg tgcttcttct 14221 gaaatcaata aatttataca agccgaatat tataatcccg aaaaaaataa tgctgaaaat 14281 tgcatcagta accgtgacga aaagttcatc ggcacttttt tccgaagtaa ctttaactcc 14341 gttaaggagt aaaaattctt tgaaggaatc cagttccgga ttgtcggtgc ggtattctgt 14401 ctggtcaccg tttaaataaa accttacttc atcatttcct atttttgcgg aaaccacctt 14461 gcctgacttc acgtaattgt aaaaatcagg gtaaggcata tattgagagt tgtctctttc 14521 aaaataaaga gttatgccga cgatgactgc aattatagcg atggaaataa tcaatacgtt 14581 tcttttgttt ttcatcagtc tttcaccctt gctttaaact tgtattaaac tcaattatag 14641 caaaatggtt tgcattatac aaagagaatt ttattcacat ctaaatattg acaaattcca 14701 atctcattac aaaagaaggc aaggaagttt tttttaaaga agtaaaacgt ttggaagatc 14761 ttgtacggaa tgtgaaatta atggagggtt ggaatgagga aatttagatt ataatgtgat 14821 aaagataaag aacaggattg gttacaaaaa atgtcatcgg aaggatgggc gttaaagaaa 14881 ttttttcagg ctgtattgat attggaaatt gtttgtcttt tggttgaaat cattgcggca 14941 atagaatctc ctctgttttg gatttttgca ataatgatag gtatatttgt tctggtactt 15001 cttcgtatgg tatggagatg cgagtggaaa atagagcaat taagaaggga aaagtagagg 15061 ggatatatac tttacatcgc tccgtaaatt aaatacggta caacaggaga atacagtaaa 15121 aattttacga tactttaaat atcaaacgta aatttactgt atataatacc tatggatgat 15181 ataattaatt ccagagggtg attatatgtt ggcaaaaata attatgaaaa actttaaatc 15241 ttttaagaat gaaacagtta ttgattttac cagaataaat tacaagtttt tagaaaacaa 15301 tgtttcgaat aatggtgttt tgaaaggagt agctttttac ggcgcaaatg cttcaggaaa 15361 atcaaatgtt ttatgggcaa ttcgcttttt attggatgag ctttttgggg aagaaaaaaa 15421 tcctgtaaca tttatgaaat gccttttttc tgatgagccg gaattttctc tacagtactt 15481 ttttgttatt gagagtaggg aaattcatta cttgattgat tttcatacag agaaaggaat 15541 aattaatgag gaattatatc ttgatagaaa gttattgctt cagagaatgg gttcgactgc 15601 aaagtcaggt attacagaaa agaaagttta tacggattta aataataaag tccttttttt 15661 aaggactgtt tatttcaaca caggattttc aggtgatgat aaagacaata acgcaaataa 15721 taatatttta cgtcagtggt ttgattacat gcaaaattca atatatgtta atccgttttt 15781 acaccgtggt atagcttatg gcaaacaaga cgtggtttta aataaatatc ttgaaaatga 15841 aggtgtaaaa gaaattaatc gattctttac gaagtataat tttgaatata ctctggatta 15901 tcttaatgaa agaaaggtca aagatgttac agaaatagtt aatgatgaca atattaaatt 15961 agtttttttt aatcgtaaag gtgtaaatgt accgattcca tatgttcttg aatcacatgg 16021 gaatcagaat ttgcttaata tacttccgtg ctttcttcgc gttgttcaaa actcaggcat 16081 gcttctggtc gatgaatttt caggtggact gcacaacgaa ttagaacgtt tgcttgtaaa 16141 ttattttttt gataatgcca aaaattccca aatatttttt gtatctcatt caacaaattt 16201 attgtcaact tcgatactga ggcctgacca aatatacgct gtcgaattta acggagaaca 16261 tggaagtcaa gtaaaaagat tttcagagga gcagccgagg ttagcacaaa acttggaaaa 16321 aatgtatctc agcggggttt ttggaggact gccaaactat gaagataaat aaagataaaa 16381 gtatcggtag gattcttttt attgtagaag aggcaaaaac ggagttttct cttttcagat 16441 aaatttttgc aatatattgg gttatgaata tatcgaaaag agaagaaata atgcagagtt 16501 ttttaaaaac agaaatagaa gtacgtcaaa agtagctgtt attaacactg aagaatctaa 16561 tatttcgagt atttctgata aaaacgatta tcttgacagg atatttgaga tattaatttc 16621 ggagtatgat ttccctgttg ataacacagc tatttattat atttttgatc gtgatccaaa 16681 atctaattta gataaaggat tgataaggaa gttaattggc caacttaaaa atgcatacga 16741 gaattataat ggacaaagag gaggagttct tttattaagt tgtcctagta taggagcata 16801 tattgtatcc aattttattg atgataccta tcttatggaa tttgacatcg gaaataaggt 16861 aaaggaatat attgcaaccc aaaacaggga agtacaatta aacagaatta ctacggaaac 16921 cctcgaaagg gctgcaaatg aaatgatgaa gtattttgaa gcggaaaaga ttgatttttg 16981 tatagacaat attggacaaa tgaaccgtga agtgtttgaa agacaggagg caaagtatag 17041 aaaagaaagg gtatataatt tggttagtct actttgaata gcatttattg acttaggaat 17101 tatagaagat taaaaacgta atgtaaaatt ttttattaaa acttttaatg gattgaaaat 17161 tcaaaaattt gggtaatgat aaaccgtcgc ataaaatttg agaaaaattc aagggtttaa 17221 ggggagaagg gccaaatggg taaaaaaagg cccgtacatt tcaattaaga agggaaaatg 17281 taacgggttt tataggggag tattaatttg tacacctata atatcgaata aaaagcaagg 17341 cgactttagc atttttataa aaaattttta aattttttgc gaaaaaaatc tgggcatagg 17401 gaagtaagat ggcttccttc tcattttaat catatccaca aatgcctcaa gccttgtcat 17461 ataacctgct tcaccggtca tttcatcaat tatcagtgta ataatgggta taccgtattt 17521 cttttgcact tcgctaaagg tgctttgagc aattatttca ggcatgcagg tgaagggata 17581 tatatggaca acgccgtcaa atcccttttt ggcacttctt atggaggcac ctatggagct 17641 gaggccatga ccgccgatat cgtcagtatt cataaattcc tttccggctt catggttttt 17701 gttttttatt ttgaagggga gaagcttctt tataaaatgt tcttttatcc aaaagctcat 17761 gctcatggtg ttatgcactt ccacacccat gttgccaagc tttctttcta tctcaaaatt 17821 aatgccggga taggcggcaa tatatatttc acccacaatg gaaaccctga ttggcctgta 17881 ttttttgtcc aaaggcatct tccgcagttt tttggcggtg gaatgaatta ttttgtttat 17941 gcttttatac cccctggctt tttggatttc attgtgaaat tcagtcatta ttctgtccgt 18001 ttctcccttg tttatctccc ggcaccttgt gaatcttgcc agttcgttta tcctgtcaac 18061 ggcaaaaacg gttttaacgg cataaaatat tgcctttaaa agctcaaaaa tactctttcc 18121 ttctgtaaga ggccttattt tctccagcac ttctttcacg gaaatattgc taagatcaat 18181 atatataaaa tttacatcat acccaatgct ttttaatatt tcggcctgaa gctttccaaa 18241 atagccgaat ctgcactggc cacagccacc gccgaaaaga atccagtccg ctccatgttc 18301 aattccgtaa ataaaatcac ccattattgt tttgaaagga agacaggcaa attcaggcga 18361 gtgcagtatc ccctgttcta acagacttct gtcggaaacc ggtggcatga cataatcaat 18421 ccccgcggtt tccagcagta cttttacagg tatatatgtg tctcccatat gtggaaatgt 18481 aattttcata taatcaccct atcatatcca aaaatgcttc aagtcttgta tcaaatccag 18541 cttctcctgt gtgctcgtca atggtaagct taaggagggg catgttgtac cgctctttaa 18601 gccgcctctc aataaactcc agaacaaaag cgtcaactcc acaggcaaag ggtgtaaggt 18661 atattattcc tttaacatcc ggatatgagg caaaagtaaa ggcgcttccg agaagttcaa 18721 agcctacatc ccagaaaact tttccctcga aaggataggc gttttttctc ttggtttcat 18781 ggtcaatgtc ccgtggagtc aaaactgtta tgttccgggc tttgagtttg tcaatcagtt 18841 tcatactaag ataaccgtcg taaatcatgt atggatggcc caataacgaa attgcagttt 18901 tgccggtgtt gttatttaat tgttcctcaa tcctgatatt ttttcggctg ttgtcgtaag 18961 ttttcagtgc ggctctaaaa gcctcaacca catccgaata gggaatattt aaagttttgc 19021 tgatttcccg aaagcttttg aatgtttcct gaggttttgc atcaacattt attttaactt 19081 ccagcaactt tatctgcctt tttaaattaa gcagtgtcat atcgggaagt ccgcagaact 19141 tggggcaggt atactcattt ttatcaacgc ttgtatacct gggtatgaat atataatcca 19201 ctttgtcttt taagctgtat gcatgtccgt gaaaaacttt tacgggcaga caagtctcat 19261 tgctgcagtg ttttacaccc cagtccaata tttccttgtt ggtatcatcg gacactttca 19321 cattgcagcc caaattacaa aaaaaatttt cccagagtac atggtgttca aagtaaaata 19381 atcctttggg tattccaacg gtcaccatcc aattgacaga ctcctttgac atataagcta 19441 tttttatatt ttcatgcttt caggcattta tatattattt acaaaaagaa ggaaatatat 19501 aattcatctt tataatatat ctaattttat acatgatgtt gctttattga aataatggca 19561 acaaattgtt tacaaaaggt caaaaaatat gtcaaaatat agaatatggc ataattaaca 19621 tgatatgcta atttttagaa tatataataa tcttagaaag acaatctgtt atgtgtttgg 19681 atgtgtaaac agtaaagatt tgaagtatgg tttcataatt tatatatacc atttgtagaa 19741 gaaggaaaca tctatcgcat tattataatg attgatagcc ggccggcttc aatgaaagaa 19801 accaaaaaac agagaaaaaa gaaagagggg attgtgtatg aaaaagaaaa ttgcactgtt 19861 aacggtagtt ttaatcgttg ctatggtagt attaggcggt tctatgacag catatgcagg 19921 acatcaatgc agtgtgacgg taattatcgg tgatgtaaac ttggatggtt cagttgactc 19981 tatagatctt gcattattgt ataatacaac atactatgca gtacctttgc caaatcgatt 20041 gcaatatata gctgcagatg taaactatga ttccagttgt acaatgcttg atttttatat 20101 gcttgaagat tatctccttg gaagaatatc ctctttcccg gcaggtcaaa cttacacagt 20161 ttattatggt gaccttaacg gggaccaact ggtaacaaca accgaccaaa gcctgcttag 20221 tgattacctt cttggtagaa ttaatttaac ttttagacaa tatgtttctg cagatgtaaa 20281 tggtgatggt acggtagatg gcattgatct cgcaattata actgcatata taaatggtca 20341 aattcagcat ttcccggtat gtccgcaaag ctaacagctg aagtataaaa taaccggcag 20401 cattttggaa attcccttcg gacgaacctt tccgtccgga gggaattttt ttaatgtaac 20461 atggatgttg atttgatgat taaattgggg taaaataaaa tcaaatgtta aagaaagggc 20521 aaggtatttt aacgatgatc attggctaat ttggcaaaaa acgctttgtt tttgaaaaag 20581 gagcataatg ctcttgttct gtgccggatt agctataaat atttttgtca ttaagttaat 20641 gccttgccgt tttggtgggt attatactgt ttatatcttt ccggcacact gaaaaagtgg 20701 aaggagagat ttttttatgc ttattttgga agctcataat ataaagaagt actatagcga 20761 cagacttgta attgagattg atgatttgaa gatttattcc ggggacaaaa ttgggataat 20821 aggtcaaaac ggttccggta agactacact tctaaatatt ctggcaaagg aaatagaacc 20881 cgatgaggga tttgtaagac aattttgcga tatagcatat atccgtcagt tttccgagga 20941 aagcatttgt gcggataaaa agcttttaaa agaatttgac ttgtctcaaa aggtgcatca 21001 aaaggtcttt agcgggggag aaaaaaccag aatcaaaatt gccaacgcct ttaaccgcga 21061 aaatcttctg gtgtttgcgg atgagccaac agcaaatctt gactataaat gtattgaact 21121 tttaaagcaa aaacttcaaa gcgtggaatc ctttttgctg ataagccatg acagaaattt 21181 gcttgacagt atttgcaaca aaataatcga ggtaagggat ggaaagctat acttttataa 21241 cggcaactac tcattctata aaaagcaaag agagatggag tataatcgtg aaatttttga 21301 gtatgaaaaa tatattaatg aaaagtcaag tattgaagag gcaataatgg gcaggcaaaa 21361 cctggcaaag tccatgagaa agactcctaa gaggatgggt aattccgagg cgaggcttca 21421 caaaagaaaa accacgcaaa agcaagagaa aatcaataat aaaataaaca gcctgaaaac 21481 ccgtcttgaa aagcttgaag taaaggaaaa accgaaggag gtaccgaaaa tcaagctgga 21541 tttttccctg accaatccgc ccgaaaacaa ggttgttatc tctgctgaca agctgtcttt 21601 cagctatgga aataaaaaaa tatttgacaa agccgggttt aaaatattga acggttccaa 21661 aactgctctg tggggcgaaa acggaacagg gaaaagcact cttttaaacc tgatttttga 21721 aaaaactgat aagaacatat atatagcgcc caaagtaaag atcgggtact ttcatcaaga 21781 ctttgaaaat ctcgactatg acaagtccgt actggaaaat gtgatgaggg acagtgtcca 21841 gaatcagact gtggcaagaa caatactggc acggctgtta ataaaaaatg atgatgtaaa 21901 taaaaaggtg gggtgtctaa gcggaggaga gagggtaaag gtgtcctttg caaagctctt 21961 tgtttccgat gccaatgttc tgcttttgga tgaacccacc aattatcttg atatgagctc 22021 tatggaagcc ttggagagtg ttctttgcga atacgaggga acggttcttt ttgtttcgca 22081 cgacagtgcc tttgtaaatg ccgttgccga ccgtctgctt gttattgaaa accataccat 22141 aacagagttt gaaggaaatc ttgacgatta cagacaaaag atgaatgaaa cttcaaaaaa 22201 agttaaagat gagacggaaa aaattataat tagaatgaaa atggctgaaa ttgcagcaaa 22261 gttgtcagtt cccgggacgg acaaagaggc acttgaagaa gaataccggc gtcttgcggc 22321 tttgctgggg aatatgtaaa caaaccgcct gccaactcta aaaatgtttc agtggcaggc 22381 ggttttaact ttacctttaa gcttcattga gtttttcttt aaaattatgg gcttgctcca 22441 gcatcatgtc ttttactttc ataagtcttg tgatatttcc tctttcattt tcgtccagct 22501 tcatggatat atattttatc gtttccgtca gtcgaggaat catgacgtat tcaagggcgt 22561 taacccttct tcttgttttt tcgatttcct gggcaaggag ctgggacgat ttttccatct 22621 gtgcaagctc aagcatgtag ggaagcacct ttgaaagggt taagatggca ccgtcaagct 22681 ctccggaagt cgaagcgaat ccataaggat atatgtcgct ttcgtcggag cttgaagtgg 22741 taaacttcag tacaggcact tccacgctca taatattctg ggtggacacg tcgaggctta 22801 tgctttgctt tggaagcata agcgcagcct caagcccttc cgacgacata acggcccggg 22861 ctatcagaaa gtcctggtgg gctttcatta acatttcttc aactttttca cggagctcct 22921 tgtttttcct taccaggtca agaaactgct tcataagttc atccagctta tccttaagca 22981 gcttgtgacc ccttcgggca acctgcagcc ttttcttgag cctggtaagc tccattctgg 23041 tcggatttac acgcataatt gccatagtaa ttctctcctt gagtatttaa gaaggaaagt 23101 tttaaacctt cttaaatttg agtctaataa cctcaattaa accttttcac gagcgcagat 23161 tgttaatttt ctgccgcttt gggcaaatat ttgtcaaggt attcgtcacg aatacgctta 23221 agctccgatc ttggaagtat tgaaagcagc ttccagccga tttcaagggt tttttcaatt 23281 gatctgtctt cattaaaacc ttgggataca tattcctttt caaaagcatc cgcaaatttg 23341 gcgtacagct tatccgtgtc ggaaagagcc gcatctccga ggattacggc aagttccttg 23401 gcttccttac cccttgcgta agcggcaaag agctggttca ttgtatccgc atggtcttca 23461 cgggttttgc cttttccgat tcccttgtcc ttaagacggg agagggacgg aagaacgtct 23521 atcggtggcg ttactccctt gcggtgaagc tctctgctta ggatgatctg accctcggtt 23581 atgtatccgg taaggtcggg gataggatgg gtcttgtcat cttcgggcat tgtcagtatt 23641 ggaatcaaag tgatacttcc ctcgctgtca attcttcttc cggctctttc atatattgtc 23701 gcaaggtcgg tataaaggta acccgggtaa cctcttcttc cgggaacttc ttttcttgcg 23761 gcggatactt cacggagcgc ttcggcgtag ttggttatgt cggtgattat aacgagcacg 23821 tgcatgcctt tgtcaaaagc aaggtattcg gctgccgtaa gcgccatacg tggagttgaa 23881 atacgctcga tggcagggtc gtttgccaga tttataaaca gtacggtacg gtctatagct 23941 ccggttctct taaagtcact gataaagtag tcagcttcct caaaggtaat acctacagcc 24001 gcaaatacaa cggcaaattt gctgtccgta cccaaaacct ttgcctgcct tgcaatttgt 24061 gccgcaagct gggcatgggg aagaccggaa ccggagaata tggggagctt ctggccgcga 24121 accagggtgt tcagtccgtc aatggccgaa atacccgtct gtatgaactc cgaagggtag 24181 tttcttgccg ctgggttcat aggaagaccg tttatgtcaa gccttttgtc gggaataata 24241 ttcggaccgc cgtccagggg ctttcccata ccgctgaata ctcttccgag catatccatt 24301 gatacgggaa gctctatact tcttcccaaa aaccttactt tgctggttgc aacgtttata 24361 cctgtagaac tttcaaaaag ctgaaccaat gcgttttgcc cgtcaacttc caataccttg 24421 catcttctta tttcaccgtt tgccagctct atttcaccga gttcgccgta ttttacacct 24481 tcaactttct gtaccagcat gagaggaccg gcaacctcgg ttattgttct gtattccttc 24541 agcatcttat tgcacctcct ttgcgatgag ggcttctatt tgctcattaa gttctttttc 24601 aatttcgttg aagtggctgt ttacctgatc ctcgggcgta tatttcgctc ttccgatttt 24661 ttccctgaca ggaagttcaa acagctcttt gatgcttact cctgcttcca gggctttttt 24721 gccgctgtaa tagaatccca gtatgagttt taacattctg tactgcttgt ttaatgaagt 24781 ataggtatcc acttcatgga aggcattctg gtggagatag tcttcgcgta tcgacttggc 24841 ggcttccaga gtaagcctgt cggacggcga cagggcgtca acaccgacta agcgcacaat 24901 ttcctcaagt tccgcttcct cctgcagaat gcgcatagtg tcggatctta atgtctccca 24961 atcccttgaa atgttttcac taatccattt tcctattatg tcaaggtaca gcgaatagct 25021 ctgcagccag ttgattgcag ggaaatgtcg tctgtaggca agacttgagt caagccccca 25081 gaacactttg ataattctca gtgttgcctg tgtaacaggt tcggaaaggt caccgcccgg 25141 aggtgacacg gcaccgatgg cggtaagggc accttctctt ccgtcggaac caaggcatac 25201 aactcttccc gctctttcat agaactgggc aagccttgag ccaagatatg ccggataacc 25261 ttcttcaccg ggcatttctt cgagacgtcc ggacatttct cttaatgctt ccgcccagcg 25321 ggaagtggag tctgccatta acgccacact atagcccata tccctgaaat attccgcaat 25381 agtcatgcct gtataaatgg atgcctctct ggccgcaaca ggcatgtctg acgtatttgc 25441 tataagaacg gttctcttca taagagattc gccggttttt gggtctttaa gctccgggaa 25501 ttcttttaaa acgtcggtca tttcgttgcc gcgctctccg cagcctatat agacaactat 25561 atcagcgtcg gcccattttg caagctggtg ctgaaccacg gttttaccgc ttccgaaagg 25621 tccgggtacg gccgcaactc cacctttggc caaagggaat agagtgtcta taaccctttg 25681 acctgtaaca agtggagcgt tgggggggag cttttctcta tatggacggc cgatacgtac 25741 cggccatttc tgcatcatgc agatatcaac cagttcgttg ttttctgtcc gaacctttgc 25801 gacggtttcc tccacagtaa agcttccgct ctttatctcc tcaattgttc cctgtactcc 25861 atagggcacc attattctgt gctccacaat ggaagtttcc tggacttttc ctattacatc 25921 gccggcggtt actttgtcac ctttttttac ggtaggttga aaatcccact ttttgcttct 25981 gtcaagggca gtaacgtcaa tacctcttgt tatgttgctg ccaaccattt ctctcatttt 26041 tacaagaggt ctttgaatac cgtcaaaaat attttcaata agcccaggtc ccagctcaac 26101 acttagaggc gctccggtgg aaaccaccgg ttcgccgggg cccaagcctg cggtttcttc 26161 gtatacctgg atggaggctc gatctccatg catttcgatt atttcgccaa tcaaacgatg 26221 ttcacttaca cgtacaacgt caaacatgtt tgcatctctc atgccttcgg caattaccaa 26281 aggcccggag actttaacta ttgttccctg gctcacgttt atcccttctt tcgacaaaag 26341 ttttaacctc aaagtcagac aataattaac acaaataaat aattaaatta tttatgttat 26401 ttatgtggtt atccataaat tattcatctc caaaaagtat gtcagcaccc acagcgcgtt 26461 ccacactttt cttgacattc atcatgccga tacccaaaga gccctgatta ccggggatgg 26521 gtataatggc cggaagtttg tgatccttat atttgtctat tgtggagacg atatcttttg 26581 cgaactgctc cgtaatgtat ataactgcat actccatgga agcaattttt tcaaccgtct 26641 cctgggcctc tgaagcgctt gtaacaggga ataccgacat accaagggct ttaaatccca 26701 aaatactgtc tttgtctcct acaactccaa ctttatacat atgactctct cagcctttcc 26761 ctaatgacat cattagaaat attgtttatt ttacctacca taatgattct tgcattttta 26821 atctcggttt cttttgccat aaggtatcct atcaaaggct caattccaaa ggtaatgtat 26881 tttgcttttt taacatagga agttataaaa ttatccgaca gtttttcaaa ctttgtaaga 26941 cttccggtac tccgaagact ttcaattccg tcctcaagca aaggaccgta ttgggtaaac 27001 ctgagctctt cgacaaggct ttccaggggg gcgtcaaagt tttcaataaa aactttgatg 27061 ccgatgtgtc cgcccgggat aaagactttt tgcaaaaaat cccatgattt tttcaggttt 27121 ttaacccgaa gaaaaatatt aatatttctt aagtcgatga ggataacaac cagctcgttt 27181 ataaacttgt tgtccaaaga gtctgaaatg cttttcatgt ggacatagtt tgccttgtcc 27241 aaaatcaggt ctattacctg cggatcgttg gtcctgctgt aagtgtctat ggcctcttcc 27301 accgcttttc tcataatgga aggcattttg gacatgttcc tgtcctttat catgagcttt 27361 aactcgctga cagggatgga tcccggctca atcagaaggg aagtctcgtc ctgctcagag 27421 aattccgcct tcaggatgac cttcacatta tggtagtcat ttgaaagcaa aaacatgttt 27481 atggtttcct gcttgggagc aagctcattt aagagactgt acactttttt gtgttcttcc 27541 tttagaatgt tttcatattc aaatacactt ttaatatctc cgtctccgct gccgtatccg 27601 gattcaagca ggactttcag cgattcgtcc gcagactttg cttctaccat tctgtcaagc 27661 tttactttat ctaaaagccg tttttcaatg gcacgtatcc ttgagactgc gtatatatat 27721 tttgattcat cgattttttt taacttcggc aattttccac tcctccttct ttagcgattt 27781 tgagctgctt cagaatagtg cttttattac ttcggcttct acttcttctc ttttcatcct 27841 tattattgct tcgaaggagt tgtttatttc aatatcaccg gactttaata taaagcctcc 27901 gcttatgttt ttggtctctt cggaaagctt aattttcccg tcaatacctt tttgtgaaag 27961 ttttttgttt atgttttcaa taaaacctgg agaaattctt tgcttatcct tgggggagag 28021 tataatctct tcacttccgc tttccacgga atttactatc atttgagaga ttatttcctc 28081 atattccctg tcaggcaagc tgtttagctt ttcaatggtt ttgttaaatg cctcatctac 28141 aacttcctgt ctcgcttgaa gctttttctt tcttgcttcc agctcagcca ttgccttaag 28201 cctttttttc acatctactg cttcctgttt tgctttctca aggatttgtg cctttttggc 28261 agcggcttct ttttgggctt cctcgattat ttttgcagct tcttcctcgg ctcgcttgat 28321 atttgcctct gcctgggcac gggcttcctc gagaatcctt tcttttattt tttccactcc 28381 tgccatgggg acactccctt tttattaata tcttatgcca ctttaccaat cattaatatt 28441 gatactatga atcccaaaat agcgaacatt tcaaccataa gtgccattac gatagctctt 28501 ccaagtcctt caggcctttt agctatcatg tttattcctg cagcggcaac tctgccctgg 28561 aaaattcctg aaatccagcc gacaaaacca acaggaagac aaccggcaaa aagaatgaag 28621 ccttctgcaa ttgacaatgg ttcgcccatt actactttct gaatggtaag gaacgcgata 28681 acaaaagcat aaattgcctg ggtactgggc agggcctgaa gtaccattac aggaccgaac 28741 ttgcccgggt cttcggtaag aactcctgca ccggcttcac cggccaaacc tacacctttt 28801 gaagaaccaa aacctccgaa cataaatgct aatgatgctc caagaattgc aaagaaattt 28861 ccagtgagaa tttccaacat agtaaactac ctcctgttat tttagattta tatattttgt 28921 ttttgcttta aagggttcaa aggctgtgcc tccgcccttg taaaactttc cgaaaaactc 28981 aatgtactgc agcctgcaag agtgaacata tgctcccagc gcattgattg caaaattgaa 29041 caggtgtcca aaagccagaa tggcgactac ggcaattatt tttaatatgt tgttgaaacc 29101 aaacattgtt gccatctggt taataatgga cgcaataacc gaagttgcaa gaccaagtgc 29161 aagaagtctt gagtaggaca aaacgtcact catgaagctt ataaggtcat aaaggcttgc 29221 aacaccgcca aaaagctttg cgataatatt tttgtttcct ctgccctggg taagaatcaa 29281 aagaactgca ccgataatca taagatactt gcctaagttt accagaccgg ttacactttc 29341 ggcgtcaatc tttgggatat agggaagtac aaacagtatg aatccggtaa acaatatata 29401 ccagaacagc gaatcaaaaa ccgcatcaag gtatttttta tccttgataa ggtttgcagc 29461 ccgaactcca agaccgacat atatgtggat ggccccaaag agcaacgaga aactaagcaa 29521 cagttccgga tcttctgtag gattgaacca cactgccggt atgttcggaa taccgaacca 29581 gcctccgaaa agcaagcccc agaacattgt ggaaatacca cagtaaacca tgagtttcat 29641 aaactttttc gtactttctt caagcttgaa caccttaagg attatagttg ccagtatggt 29701 cattatggca ccataaccac cgtcgcttag cataagtccg aaaaacaata taaaaaatgg 29761 agccattatt gcgttcgggt caatttcttt acagtttggc acactgtaca tgttggttat 29821 tgattccaca gtacttggga tggccctgtt ggcaagcagc acagggaatt cctcgtcttc 29881 tttcggcttg acgatttcta tgtagcaatc actgcttttt tcaaggaagg ttttaacttc 29941 ttccgccgag ttttcgggga gccatccttc cagcatgaac accttgttgg ttttgagcag 30001 atttgagagt acgatttttc gctctctttc aatggacagg taatcgtgaa gaacttccaa 30061 atcgtccttg tatttcacat aagatgtcat attttcttcg atatactcga tttcctcttc 30121 tattctttct atgttttcca aagcttgatc gatattgtgt tttacagttc ctgaaagctc 30181 tttgaaagtt accttggaaa agccgtactg ctttaataca ttcataacgt cttcttcttt 30241 ggaagttaaa tatatgataa gaagataact ttgctccttg tctctgctaa gaacttcaaa 30301 atggctttcc gggacttttt catcgagatc ctgttttatt ttatcggtat ttgccatttc 30361 cggcacaacc ccgatcaaaa ccgtggaaga tgcagttgcc gtaagttcta agggaatgtc 30421 caaagcttcc cacggtttga gactcaaaat catatttgag ttcctgtttt tttccgcctt 30481 taagtttgcg agcatttcat cataccggtt gacttcatca ataacggacc aaagcttatc 30541 ctggttttgc aaaaccatgt tcaactcgct tgtgctgata tcccgtctcg ctgaaaagag 30601 aggttttttg cgcttgtcaa atttgtccag atagtcaata acggccgata ctctgtcaat 30661 ctgagcatca agccttgaga cgctttcact gtctccgtca atatttacca gctctttcca 30721 ttcatcggaa gatatttttt cttttgcatc cgtaatctca acgacaccta atttcatgag 30781 attttcgagg atgcgttcct tttcagattc aagccctata agtgagattt tattcatttt 30841 aactattgcc attggggctc actatccttc ctatgattat ctccacggcc ttgtccagct 30901 tcttcctggc gttttgtttt attgagtcgc attcggaaga aatttcggcg gcaaattttt 30961 caatttcggc atttgcctcc ttttcagctt cctgaataat cttttttgct tctttttccg 31021 catcttcctg agcttgttca agaagcttgt aagactgggt tgaggcctct gagagaattt 31081 gccgggcttc ttcaagagac tgccttttta tctgttcggc ttcggattcg gattgtttaa 31141 tggatttaat aatatcgagg gacaccaaat caccaccttt agtatgtatt taattcacgt 31201 cggtttcagt ttatactgct gcaaaaagtt tgcacttcct aaataatttt tccactcatc 31261 aacggatctt aatacattct tttgaccttg cttttagatt ggatcggtca tttaagacta 31321 ttaatatatc gttaaaaact tataaaaaac ttaatataaa taatagcatt ataaaagata 31381 tatatcaaga taatcggcag agaattacat tttattttag ccgtcattta aaaattattt 31441 cagttggaaa aaagaaaaaa tgatgatatt ataatatgag ataacggatg gaaggcttgc 31501 aaccggaaaa gcttttacaa aaaatacaca aaataacaag gagtgtttta tggttaaaat 31561 tggttttttg ggccccaaag gaactttttc acaggaagcg atgcttgcat atacgaaggg 31621 gagcaatgat tttgtcgggg ttgattacaa cacaatggtg gaattgatta tggcagtgga 31681 gaatgacgag atcgatgaag ccgttgtacc aatagagaac tctcttgagg gcgctgtaag 31741 cactacgatg gatatgcttg catgggatgt ggaccttaaa atcaaggccg aggttgttat 31801 tgaaataaaa cagaatctca tggcaaagaa aggtacggac attaaagata taaagtatat 31861 cctttcccac ccccagcccg ttggacagtg caggaagttt ttgaattccg tttttcccca 31921 tgcggttgta aaatatgtgt acagtaccgc acaggcagca aaggaggttg cacaggggga 31981 tggaaatatg gcttcaattg gctctttggc ggcggcaaaa gaatatgggc ttgaggttct 32041 taaagagtcc atccaggata acgacaaaaa ctttaccaga tttgtggtaa tttcaaaaaa 32101 agaagcaaaa aaagccgaaa agaacaaaac ttccatagtt ttttcaacgg aaaacaagcc 32161 gggcagcctt tacagaatac tggacatatt caacctgtgg gacataaaca tgacaaggat 32221 agaatcaagg cctgcaaaaa acgagttggg caagtacata ttctttgtgg atataaacgg 32281 gcatatagag gatgaagatg tcagggatgc cttaacaatg gtaagaagaa agacttcctt 32341 ttataaattt ttgggttctt atccggaatt tgaaatagga tgttgaaatt gttgatattg 32401 aacttgcctg agatttgttt ttcgtttttt gggaaattcg gtgcgaaagt ttattttgtg 32461 gtataatata tgttatatgt gaatacatat cttatatttg aatgttggag tggttttatg 32521 gctttgtttg acagggagat tgacattacg agaaatataa aaattattga gtggctaaag 32581 agcgaacttc ttaccgacat agcaaatctt ttcaaagtgc tggtgaatgg agttagggaa 32641 gaagtgcatg aatcagtcgc ggaaaccctg tccaatataa ttttaatctg ctacatgctt 32701 ggcaggcgtt tgggtgtgag ttataattcc attgagatta aaataaacaa caaaataaaa 32761 cttggtataa ttgaaaatca tgatgtggaa aaatattacg gggatttaac cgaacttgca 32821 aagcatttga actcctctag aatgcagaat aaggtttagg gcataaaata caggaggagt 32881 ggcgatggaa agtaaaaaat ttattgggat gtttttacca aaatcaagtt tttatctgct 32941 gattatattt tttctattga taattatttc aattctggaa tttacggttg ccataccggg 33001 ctatgcgttg tttttgctgc ttttatatta caactttcgg acaaattaca agagacacaa 33061 ggaaataacc cgatatattg aaaatttgac attcaatata aatacggcgt caaaggatac 33121 gctgctcaat ttccccatgc ctttggtttt gattgagctg gacgggacaa ttatctggta 33181 taattcgtct tttaaaaaaa tctttgacgg ggagaaactt ttagagaaga caatacattc 33241 atttataaaa gaattgaatc ctgatgaact gtccaacggg aacgtgaact ttagcaagga 33301 tattgtgata aacggaagaa actactgtgt attgggcaat ttcgtgaagg tggacagcaa 33361 aataaatgaa gacgggttca taatacttat gtattttgtg gacaacacgg aactggtgga 33421 acttaggaaa aagtatgaaa atgaaagagc aacggtggga attatcataa tagacaatta 33481 tgatgatttg atgcagagcc tggaagatac gatacgcacc caaattcttg cggaaataga 33541 tgcgaagata acccggtgga tgggatatac caacggtata cttaaaaaat ttgaaaggga 33601 taaatatata ctcattttcg actataagta tcttaaggat tttgaagaga aaaagtttga 33661 catcctggat tccgtcaagg aaataaatgt ggggaacaag attcccgtta cgctgagtat 33721 tggaataggt gtaggaacgg attcgctgct ggagaagttc cgttttgccc gcgcatcttt 33781 ggacattgcg ttgggaagag gcggcgacca ggtggttgta aaaaacgggg aaaatatatc 33841 tttcttcgga ggaaagacca gggagctgga gaaaagaacg aaagttaaag caagggttat 33901 tgcctacgca ttgagggagc ttattgacca ggcctcggac gtaatgataa tggggcatga 33961 gaactgtgac attgactgtc tgggagcggc tctgggaata tacagggtgg caaagaacag 34021 aaacaaggag gcccatatag ttttaaacag ctcaaatcct acaatagatg ttttgatatc 34081 aaaaattgaa aaaagcggag attatgaagg cctgtttata gcaaaggaag aagccattga 34141 gaaaatcagt aaaaagacac tcttgattat tgtggatacc cacaggccga gttttaccga 34201 gtttccggag cttttaaaat atacggatca gatagtggtt atagaccatc acagaagagg 34261 tgcggattat cttcaggagg cggtgcttac ctatcaggaa acttatgcct catccacatg 34321 cgagctggtt acagagatac ttcaatatgt ggaggaaaaa ataaagcttg cgcctgttga 34381 agctgaagcc ctgtatgccg gaatagtggt ggataccaag aatttcacat tcaagacggg 34441 agtgcgcact tttgaggcag cggctttctt aagaagacac ggggttgaca ctgtttcggt 34501 aaggcagatg ttccaaagtg acattaatac ctatataaac atttccaatg tggtaaggga 34561 agcggaaata gtaagggaca acgtggcaat atccgtttgc ccgcagaatg tgaaaaatgc 34621 tacattgatt gccgcccagg cggcagacca gcttgttaat ttggcaggac ttaatgcggc 34681 ttttgtactg agccatatta acagcggagt tgccattagc ggaagatccc tgggggatgt 34741 gaatgttcag gtaatccttg aaaagcttgg aggcgggggc catatgacgg ttgccggagc 34801 ccagcttcag ggagtgacgg ttgaagaggc aaaagcaaaa cttgttggag cgattgatga 34861 atattttgtt gaaatcaaca gacaaaacgc atagtattct gttattatat aagtaatatg 34921 attttaagga gaggtatgtt atgaaagtta ttttaaaaga ggatgtcaag ggacttggga 34981 aaaaggaaag tcttgttgag gtaagtgacg gatatgcaag aaattttctg attccaaaag 35041 gcctggctgt ggaagcgact gcggctaata taaatattat gcagactaaa aaggaagccg 35101 aaaagaacag aaaggagcgg gagcttgccc aggcaaagga acttgctgaa aagcttaaag 35161 gcatagtggt tactctcaag gcaaaggcgg gagaaaacgg aaagcttttt ggctcaatga 35221 ccagcaagga tgtgtcggat tatttgaaaa aacagcacaa tcttgacata gacaaaaaga 35281 aaataagtct tcctgaatcc atgaaatcac tgggtacata tgaagcagag gtaaagctgt 35341 atccgggagt aagtgctaag ttgacggtta agattgaaca ggaatgattt tgagccagtc 35401 tttggcgaaa atatgtttat gtcaggatga gtgatgatat atggacttgg gttcttttgg 35461 ccggataccc ccgcaaaata ttgaggctga gcagtcggta ctgggtgcca tactgctgga 35521 caaagaagtt ctgtcaagtg taacggagat aatttcaagc caggactttt acagagagga 35581 ccatagggaa atattcgaag caataatgga cctttatgaa aagggagaac ctattgacct 35641 cattacagtt gcggaacagc ttaaggtaag agggagtctg gaggcggtag gtgggcttga 35701 gtatcttacg aatctggcaa gtttggttcc taccactgca aatgcaaaac attatgcaaa 35761 aatagtcgaa gaaaaatcta tattaagaag gcttatcaag gcttccagtg aaataatcaa 35821 tatgggttat gaagccgcgg aagaggtttc ctatgttttg gacaaggctg aaaaaagcat 35881 atttgacgta cttcagaaga gaaacaccca ggggtttgcc ctgattaaag atgtattgat 35941 tgatactttc aaccggcttg aggagcttta caacaataaa ggatacatca caggaattcc 36001 caccggattt gtggatttgg actacaagac tgcagggctt caaaattcgg acttgatatt 36061 gattgcggca agaccggcca tggggaagac ttcttttgta ctgaacatag ctcaatatgc 36121 tgccattcac gcaaaggtgc ctgtcgccat attcagtctg gaaatgtcga aagaacagtt 36181 ggtaaacaga atgctatgct gtgaagccat ggtggacagt cagaagatga gaaccggaaa 36241 gctggaggac agtgactggc agaaagtagc aagagcattg gggcctttgt ccgaagcgcc 36301 gatttatatt gatgacaccc ctggactttc tgtcgcggaa ataagggcaa aatgcagaag 36361 actcaagctg gaaaaaaatt tgggcctggt tgtcatagat taccttcagc ttatgcaggg 36421 aaggggaaaa agtgagagca ggcagcagga aatatcggag atatctaggt ctcttaagat 36481 actggcaaag gagataaacg tacctgtgct gactttgtcc cagcttagcc gtgccccgga 36541 gttaaggtcg gatcacaggc ctattttaag cgacctgagg gaatccggcg caatagagca 36601 ggatgcggat atagtaatgt tcttatacag ggatgactat tacaatcccg atactgaaaa 36661 gaagaatatt gccgaagtga taattgcaaa gcacagaaac ggttcgacgg gtactgtgga 36721 actggcatgg ctgggtcagt atacgaagtt tgcgaacctt gagaaatata gacaatagtg 36781 ctggaatggt tttatgattg acaaggtatt ggaaacaatt aaaaaataca atatgataaa 36841 caacaaagat aaaatagtgg tcggagtgtc cggcggtcct gattcggtgt gccttctgca 36901 cattctgtgc aaacttaggg aaagcatgga tttggggctt gtggcagttc atgtcaacca 36961 tatgttgaga ggggacgaag cttccggaga tgaggctttt gttgagaact tgtgcaaaaa 37021 attgaatgtt gaacttgtca cccggcgtat tgacataaaa aagcttgcaa aggaacgaag 37081 gctttccctg gaggagaccg gccggataga gaggtataga ctttttgagg aagttgcgga 37141 taacttcggc gcccaaagaa ttgctgtggc ccacaataaa aatgaccagg cggaaaccgt 37201 gctgatgaat attataagag gcacaggtct tgacggactt aggggaatgg attatattcg 37261 aggtaggata ataagacctc ttttgggtgt tgagagaacg gaaattgaaa attactgccg 37321 gattcacaac ctaaatccgc gtattgacag tacaaatttg gagaatattt ataccagaaa 37381 caaaataaga cttgatctga taccctatat agagaaatta ttcaatgccg atatagtaaa 37441 tggcataagc aaaatggcag atttaataaa agatgacgta agctttatcg aaagccggac 37501 agatgaaatt tacaacaaag caaaaataaa gagcgatgac aagggagtaa ttttagatct 37561 taatatttta aaggaatgtc acattgcggc tcggaaaaga ataattcgaa attccataaa 37621 acaaatcaaa ggtgacataa aaggaattgc aacagtgcat attgacagta taacagatct 37681 gattgaaaac ggtaaaacgg gatcaatgct gcaccttccc cacggagtaa gggcagtgaa 37741 atcctataat accttgaaaa tatgtttgca cgagcttaaa gaggaagaca tatatttcaa 37801 taaggaagta aacatacccg gaattacggt tgttgatgaa atatgtggca gcttggaggc 37861 aacccttatt gatgtttccg cagattgctt tagtatagag gattttacaa aggtaccgga 37921 caaaagcaag gttcagtttt ttgattatga caggctgaaa gagggaatat acttaagaaa 37981 cagaagagac ggtgatgttt tcaggccccg taactcaaac ggcaccaaaa aactcaagga 38041 gttttttatt gacaataaaa tcccaagaga aacaagaaat caaataccgt taatttcaac 38101 acgtaaagaa attgtatgga taataggtta caaaatcagt gataaattta aagtaactga 38161 aaatactaaa atcatactga aattatccta tgataactcg cactgaacca atcaaaattc 38221 taaaaaccgg catattggtg ttaagtgaaa gacgacggtc ttatgaatta tggattgtta 38281 gcttataaat tgcccgatta cagattaaaa tatatagatt aaaaatagct taaaaaagcg 38341 tatatttagg aggaaactca tgataaatca aattaaagaa attttggtta ccagagagga 38401 acttaaaaac aacgctaaag agttgggaaa gaggatttcc agtgactatg aaggaaaaga 38461 gcttgtcctg ataggggtgt taaaaggagg agtggtattt tttgccgact taataaggga 38521 aataaccata cccattgatg tggatttcat atcggtgtca agttacggca attccaccaa 38581 atcatcgggg gttgtgcgta taataaaaga catcgatata gatataacca acaagcatgt 38641 ccttatcgtt gaagacttgg tggatacagg tcttacgctg cattatctga aaagcatgtt 38701 tgaagccaga ggacccaaag atgtaaaaat atgcaccgcc cttgacaaac cgtcaaggag 38761 aaaggttgat ttggaaatag attataaagg tatcacaata ccggataagt ttgtggtggg 38821 ctatggattg gattatgcgg aaaaatacag aaatctcccg gatgtgtgcg tgctggattc 38881 gtctgtttat acggacaaag aagatatgga ctaaaaaata tacaaaggtt tcttgtgttt 38941 ttaataccgt tatgttaata taatgtaata tatattttat aataatatgt atgagagata 39001 gtgttttgct atattgctat aaagaatgag gagggaacta gttgaaatat tttaaaaata 39061 taagctttta tatagtgctg tttgtgatgt tgctggcttt tctggtcata gtgcaaagcc 39121 ggcctgttga aaaggaacaa aagtattccc agcttataag cgatattcac aacggtaagg 39181 ttcaggaaat tatactggaa gacaataaag ccacggtaaa atataaagaa gagggacaga 39241 gggaccagtt tgtttatata cccgatgttg aagtgttcat gaatgagata aacgacctta 39301 tcagagaagg agagcttgag tttcgaagca aggttcctta ttcgccgccg tggtggattt 39361 ctatattgcc tactttggta attatagttg tgtttgtgct gttctgggtg ttcttcctcc 39421 agcagtctca gggcggcgga agcagagtaa tgtcttttgg aaaaagcaga gccaaaatga 39481 caatagacga taagagaaaa gtgactttca atgacgtcgc aggagcggat gaggagaaag 39541 aggagctaag ggaaatagtc gaatttctga aaaattccaa aaagtttttg gagttgggag 39601 cgaggatacc aaaaggagtg cttttggtgg gacctccggg tacaggtaaa accttgctgg 39661 caaaagccgt gtccggagaa gccggagttc cgttcttcag cataagcgga tcggactttg 39721 tggaaatgtt tgtcggtgta ggtgcttcga gggttagaga cctttttgaa caggcaaaga 39781 agaatgcccc ctgtattgtt ttcatagatg aaattgatgc tgtcggaaga catagaggag 39841 caggtctcgg cggcggccat gacgagagag aacagacgct taatcagctg ttggttgaaa 39901 tggacggttt cggagcaaat gaaggggtaa taattctggc tgcaacaaac agaccggata 39961 ttttggaccc tgcgctttta agaccgggaa gatttgacag aagagtagtt gtggggcttc 40021 cggacataaa aggaagagag gaaatactga aagttcatgc caaaggcaag cccctggcgg 40081 aagatgtcaa attggatgaa cttgcaaaaa gtacccccgg atttaccgga gcggaccttg 40141 aaaaccttct taatgaagca gctttgcttg ctgccagagc caacaagaaa gtgataacaa 40201 tggctgaaat aaaagaagcg acattcaagg tggtcatggg accggagaaa aagagcaggg 40261 taatgagcga gaaggaaaaa aggcttactg cctatcatga agccggtcat gccattgcaa 40321 taaaagaagt ttccactacc gacagggttg acaggatatc cataattccg tcgggtatgg 40381 caggcggttt taccgcacac aaaccagatg aggataaaaa ttatgagacc aagtcccatc 40441 ttattgaaaa gattatcgtt gcattgggag gaagagcggc agaggagatt gtgctgggtg 40501 aagtgagcac cggagcatac tccgatctga agcaggcaaa cggaattgcc agaagcatga 40561 ttaccaaata tggtatgagt gatacccttg gcaatctcgt atttgcaaat gaaagtgacg 40621 aggtatttat cggtagggat tttgtccaga caaaaaacta cagtgaggag atagctgctc 40681 aaattgacag agaagtaaag aagataatag attcatgtta tgaaagaata aaaaatattt 40741 tgaaagagaa tataaacaaa cttcatgccg tagccaacgc ccttatggaa aaggaaaaac 40801 ttgaaggtta cgagtttgaa gagttgtatg caaatgcatg atttattctt tgaaaaaaac 40861 agctttctga aaagagatgg tgataaactg tctctttttt tactttatta tcacatatgt 40921 atttgttata ataaacaagt attttagact gcaatttttg attgcaccaa aataaaatcc 40981 ataatttttg agtagagagg gaagagccat ggaaaatgtg aatttgaaag taggtttgaa 41041 tgcatctgtt gaaacttggg tttcccagaa aagtacggcg gaagaatacg gaagcggaaa 41101 tatggatgtt tatgctaccc ccgcaatgat aggcttgatg gaacgtgctg cattgtcagc 41161 tgtggccctg catctgccca aagggtatac caccgtcggt actgcggtaa acatcaagca 41221 tattgccggt acacctgtgg gaatgaaagt aaaagctttg gcagagttga tagctgttga 41281 gggaaggaag cttacattca aggtggaggc ttttgacggt gtcgaaaaaa tcggagaagg 41341 gtaccatgag aggtacatag tctcatctca aaatttcaga gataaagtat ataagaaagc 41401 ggaaaacatt tagtacgaga aatctggcga aaatttcaat aagaaaaagt ttttatattt 41461 attttatatt tattgacgaa atataaggta tatgatacat tatactatga caaaataata 41521 caggtaacct tatcaagaga ggcggaggga atgggcccta tgaaacccgg caaccggcag 41581 aattgtatcg gtgccaattc ctacaggatg taaaagtcct gacagatgag gataaaaaaa 41641 gaatcctctt tgtgtgaaag aggttttttt atgttatttt gtcagttttt tcgacaagtt 41701 gcggcaatgc agcaacgggt gttgtttatc gcaagggaaa attttgatga ggaggtaacc 41761 taaatggcaa gaaaactgtt tacgtcggaa tctgttacgg agggccatcc cgataaaata 41821 tgcgaccaga tctccgatgc cgttctggac gcaatttttt cgcaggatcc tatggcgagg 41881 gtagcatgtg aaactgctgt taccactggg ctggtcttgg taaccggaga gattacaaca 41941 aattgctatg ttgatatacc aaaaattgta agaagtacaa tccgggaaat aggttatgac 42001 agagcaaagt acggatttga ctgtgatacg tgtgcggttt tgacttcaat tgacgagcag 42061 tctcctgata ttgccatggg ggttaacaaa gccctggaag caaaaacagg ggaaatgagt 42121 gacgaggaga ttgaagccat aggagcaggc gatcagggaa tgatgttcgg ctttgcgtgt 42181 gatgagacgc ccgaacttat gccaatgccc atctcattgg cccacaagct tgccatgagg 42241 ttaagtcagg taaggaaaaa cggcacgttg aattatttga gacctgacgg aaagtcccag 42301 gtcactgttg aatatgacgg ggacaagcct gtaagagtgg atacggtgct tatttccaca 42361 cagcatggtc ctgaggtgga ttacgataca attaaaagag atgtaattga gcatgttata 42421 aagcctgtta taccggcaga acttttagac agtaaaacaa aatatcttgt caatcccaca 42481 ggaagatttg tgattggcgg gccccaggga gactccggac ttaccggaag gaaaataatt 42541 gttgatactt acggaggtta tgcaagacac ggcggcgggg cattttcagg aaaagatccg 42601 acaaaggttg accgttcggc tgcatatgcc gcccgctatg ttgctaaaaa catagttgct 42661 gcgggacttg ccagaaaatg tgaagtgcag ctggcttatg caataggtgt ggcaagaccg 42721 gtttcggtga gggttgatac ctttggaacc ggaattattc ctgaagaaaa aatagaaagc 42781 ctggtaaaca aatatttcga cttaagacct gcgggaatta tcaaaaccct tgacttaaga 42841 agaccgattt acaaacagac agcggcttac ggacattttg gaaggactga catagatctt 42901 ccatgggaga ggaccgacaa agccgaagag ttgagaaaag aggctcaaag tttgtaagat 42961 tggacgtatc ctaaaaaagt aaatgaaaaa gaaaattcca tataaaatac agcaatttaa 43021 atttcacaca aaatatgaga attaatataa gaattttcat acaaaatata agaattgaaa 43081 gaagcaaata aagtaagcaa taaacaggcc gaagcggacg ataaatttgt ctgctttggc 43141 ctgttttttg aaaataagca cctgtaacag ttgtacagtc ggtttcatag actgataact 43201 gggggtgttg ttatggcgga aattattttt gaagtagcaa cgtgtgtgct ggcagcttac 43261 ggccttatgg tactgataca tcagtttctt gtttatataa aacagcataa caaaggctac 43321 agaaactccc aggtaaagct tgtgctgatt gtcaggaatc agggggaaac aattgaaggg 43381 gtgttaagaa acgttcttcc cagggatttt atcagaaaac ttatgccggg aggaaagctc 43441 catgtgcttg acatggattc ggatgatgat acgttggata ttttgagaaa actggaaaaa 43501 gattatgaat gtcttgaggt gctgaggaaa agtgaaaaag acgcactgtt cagatgtttt 43561 gaggaacctg agaataatga tgccgtttgg gaacatgcga aaagaagaaa tgtataggaa 43621 tattttcctt ctttcttttc gaaaccctat atataaggta tacttgaata tgtaatttca 43681 tataaaatac gagggataag gtggataatt tggtaactat tgaaggtact gttgaagaaa 43741 ttatattctc caatgaagcc aatggatata ccgtttgtga gataaaatgc gataaagaag 43801 ttattaccgt cgtgggatat atgcctttta tcaatgtggg tgagacgctg agagtttcgg 43861 ggaagtgggt catccaccct gactatggcg agcagctcaa agtggagctg tatgaaaagc 43921 tgcttccgga aacgccggag gctatagaaa ggtatcttgc gtcagggctt atcaagggag 43981 tcggccctgc aaccgcaaaa aagattgtaa agaaattcgc agaccaaact cttcatatta 44041 taagtcatca cccgcagagg cttgccgaga taaaaggtat taccatggaa aaggctttga 44101 gaataggaca ggcctttgag gagcaaagag gccttcggga tgttgtgctg tttctgcagg 44161 agtatggcat aagtccgact tattgtgcca aaatatacaa gactttcgga ccggatacca 44221 tagaagaaat caggaaaaac ccttaccggc tttcagacga gattttcgga ataagtttca 44281 gaacggctga ccggatagcc aaaagccttg gaatagaccc ttactcaaaa tacaggattt 44341 caagcggtat caaatatgtg ttaagccggg ccgcgacaga aggtcatact tttttggaag 44401 aagagatgct aaaaagttat acgtcaaaac ttttggacat caacattgac agcattgaag 44461 acgctctcgt ttcccttgtg ctgaataagt cggtgtatgt ggacagaaat gacgggatgt 44521 caaagatata tttgagttca ttttaccatg cggagctggg agtatgcaga aagctggtgg 44581 aactttccca ggtaaggtat agcgccgata tggaggactt tgaggaaagg ataaagcagg 44641 ttcagaaaaa agagggtata atacttgcgg acaagcaaaa ggaagccatc agggaagcaa 44701 tgactaacgg cgtgcttgtc ataaccggag ggccgggcac aggcaagaca accataatca 44761 aaagcattat aagccttctt gaaagtgaag gatatgagtt tgcccttgca gctcccaccg 44821 gcagggcggc aaagaggatg tccgaggcta cgggctatga ggcaaaaacc attcacaggc 44881 tccttgagat tggttatacc tcaaatgagg acgagcttgt gtttatgagg acggaagaca 44941 atcccataga ggctgatgtg gtgataattg acgagatgtc catggtggat ataattctca 45001 tgtaccacct gcttaaagct attgtctgcg gaacaaggct tatactggtc ggagatgtgg 45061 atcagcttcc ttcggtgggg ccgggaaatg tcctcaggga tataataaaa agtgggatga 45121 tcaagaccgt aaagttgtct gaaatattcc ggcaggccgg agagagtatg atagttgtca 45181 atgcccacag gataaaccgc ggagagcatc ctatattaaa tgagagggaa aaagattttt 45241 tctttgtgac aagaaattcc cagaatgata ttttaaaaac cgtggttgat ctttgtacaa 45301 gaagaatacc cgatacttac ggatatgatc ccatgaaaca gatacaggta ttgacgccta 45361 tgagaaaggg tacggtggga gtggcaaacc tcaatattga gcttcagaag gttttaaatc 45421 ccgaagacgg aaaaaagaaa caaaaagcct tcagaaacta tgtattccgt gagggagacc 45481 gggtgatgca gataaaaaac aactacaacc tcagatggga aaaaatcaac ggcccgggcc 45541 aggaaggagc gggtgtgttt aacggcgata tgggaattat agttgaaata gatgatgaag 45601 agcaaaaaat aaaggttttg tttgacgatg aaaagcttgt ggaatatgat tacactattt 45661 tggacgagct tgagccggcc tatgccgtta ccattcacaa aagccaggga agtgagtttc 45721 ccgtggtgat acttccggtg tttcccgggc cttcggtgct tatgaccaga aatcttttgt 45781 acactgcgat aacaagggcg agggagctgg tgatactggt gggcaataaa gattgtcttt 45841 acgggatgat tatgaacgat cgggagacca aaagaaactc ggatttggct gaaaaactta 45901 gaaaatgcat agtgggagtg gactggttga aacaatggta aactggatta taaatctcat 45961 atttccccca aagtgcatat tctgcggaac aattttgggt acaaatacta aaatagaaat 46021 atgcaaagag tgctatgaaa agattgattt caaggaagga gcaagtataa gcttccaggg 46081 acaatacaac tactacgaca gtgttgtctg tgtatgcgac tacagcggca ttgtaaagga 46141 agccataaga aaatacaagt tttacaataa gccttcttat tacagaacct ttgcacggct 46201 tttggcacaa aaaataaagg aattgatcca gtggcagaaa tttgacatga ttgtaagcgt 46261 tcctcttcac ccggaaaggg aacgaagccg cggatacaat cagtcgtacc ttattgcccg 46321 ggaacttggc cgtgagctgg ggataaagaa tgaggcaaaa gttttgaaaa gggttagaaa 46381 tacttacagc caaagccttc ttaagaagga agacaggctt gtgaacgtaa aggatgcatt 46441 tagaataacc gatagatcca aagttgaagg aaaagcaatg tttcttgtgg atgacatttt 46501 gactaccgga acgacactga acgagtgcag cagggtgttg aaagaggcag gggcgaaaaa 46561 gattgtggtc gctgtcattg cgtcgggaag aaggtaaatt gggcactatt aagctatata 46621 aataaactgc cgaaatatat aatgaggatg ttaatatgtt ttctaagtat tggggatatt 46681 attggtgtag gaggaatcgg tatgccggat ataagaaact gcaaacgatg cggaagactt 46741 ttcaactata tcggaggacg ccccatttgc caggattgca agaaacagga tgaagaagaa 46801 tttaaaagag tgaaagaata cctttatgag catcccaaag cttccattat tgaggtgtcg 46861 aatgcgctgg atatcagtgt tcagaagata aagagctatc tgagggaagg tagacttgaa 46921 attgtcggaa ccgaagggaa tgtagtgctt gaatgtgaaa aatgcggcaa gtccataaat 46981 acaggaagat tttgcaatga gtgttcccgc gaacttaccg aggggtttaa agccaccgcg 47041 caggaaataa gcaagtcagt atccggtgat accgacaaga aaaagacatc gggaatggga 47101 atgaaatact tgaacagata tgaaagatgg aattcggata aatgatgccg gaactttttg 47161 ttggcggtat tagtcagcat attatacggg aataagtttt taatattttt atgaactata 47221 ttaagcttaa tattgtactt aataatagta atatttattt attaattaaa tattttagat 47281 gacgatataa ttaatgaaag gaagaataaa ggaaccaatg ataaagtcaa tactttaaat 47341 ttaatataga aagtttttat gaaggtgagt ggtaattatg aaaatctggg agggggtccc 47401 aaaggtttca ggcatctatg acagcggtaa aaatgtaaac aaagccgaaa aaactgacgg 47461 tgtgaccggt aaaaaagatg tggtatccat ttcaaatcag gcaaaagact ttcagacggc 47521 aatgaaagca ttgaaagaaa taccggacat aagaaaggac aaggtggaag aattggcacg 47581 aaaaattgag tccggcactt acaaagtcag tgaagaagac atcgcagaca agattttaaa 47641 atcaatattg gacagaaaaa ctcaaggatg atttggtatt tgcgggatga taggaggaaa 47701 gaaattccga gttgtcccgc aataaatttt atttcaggca attttcaaaa gaagaatttc 47761 acaattcaaa ggagtgttta caatatgaac gacagactga taaatgattt aatggatgtg 47821 cttttgcagg aatcaaaaat ttatgaagat attcttgaaa tttcaaaaaa gaaaaccgat 47881 gttattgtta aagggaaagt cagcgagctt gagagcatca caaatctgga acagtccctg 47941 atagttaaaa ttggaaaact cgaagaaaca agggagaata tcgtgacgga aatagccggt 48001 attgccggaa tggatccttc ggagatgacg atatcagagc tggaaaaaca tgtggatgaa 48061 aagcaggccg aaaagcttag ggaatacaaa aagcatatga cgtcaattat tgaggaaatc 48121 aaaaatatca atgaagtaaa ttccagatta ataaagaact caatagattt cattgatttt 48181 tcgataaata ttttgaccag tgctaatttg ggaggaaaca attacagcaa agagggacaa 48241 ataaacgaga acgggaaaaa aggctatttt gatgtaaaat tgtaatcgtt tggaggcggt 48301 atatttgggt ttcgctggct tggaaatcgc aagatccgga atgtatgtca atgaacgcgc 48361 tttgtctgtg acgggacaca atgttgccaa tgtaaataca aaaggttatg cccggcagca 48421 ggccatgatt acgacgggtc cctatctcaa ccttatgaga tatcaaatcg ggcttggtgc 48481 aagcattcag gagaccaggc agataaggca tttgtttttg gataatatct acagaaatga 48541 aaacaccgag ttgggatact gggagacaag aagcaagacc ttccaggaaa ttcagaccat 48601 tcttggtgac ccgatgggag atgggctcca aaacgtttta aatcagttct ggaacgcatg 48661 gcaggagctt tcaaaggaac ctgacagcct cactgtaagg gctctggtaa ggcagcgggc 48721 ggaagctctt gtacatcaga taaatcattt gggtgcacag ctggacaagc tgcaggagga 48781 cctgaaccaa caaattgtgc tgacaataaa acagataaac gacataacga agcagatagc 48841 ggaattaaac attaaaataa tgcaggagga agtttgcgga gataatgcaa atgactaccg 48901 tgaccagagg aatttgcttc tggatgaatt gtcaaagctt gcggattttg aatttactga 48961 aatgcagaac ggcgatgtgc aggtaaccct cggtggatat attctggtaa caaagggtga 49021 gcaaataaat cttgttgcag gaaagagcga tataaacaaa atgttttttg ttcccaaaat 49081 tgaaggcgag aatatcgaag ttccggtaaa aagcggggtt ttaagaggac ttttggagtc 49141 gagaggagat gtttcgggtt ccattgaagg aattacagac cctgccgcaa atcctgtacc 49201 ggcttcggca aatattgtgt ccgatttgaa gatgaggctt aatgtacttg ttaattcgct 49261 ggtcacgcag gtgaacaacc tccataggag cggtaagact ttggggaatc ccccctctga 49321 cggagaggac ttttttgtgg ccataaatcc cgcatatccg ctggaaatgg gaaacatcaa 49381 acttaatgac aaccttgcgg atcttgacaa tattgttgcg tccaaaagtg gagccagcgg 49441 tgacaatact attgccctgg ccattgcaaa tttgagggat aacagggtaa ttgccgatgt 49501 aagcggtatg gtaagcctgg atgactatta tcagacaata atacttattg tgggtacagg 49561 tggttctgaa gcagaaaaga cggcagaaaa ccagaggact ctggtaaatt cggcagaggc 49621 gcaaaggcag tcaataatgg gagtttccat ggatgaggaa atgtccaaca tgatgagata 49681 caaatttgct tacagtgctt catcgagagc gataaacgtt atagatgata tgttggagac 49741 gattattaca agaatgggat tagtgggcag gtgataagat atgagcagtt tcttcggatt 49801 taacgtggca gtaaagggat tgttcacggc tcaaagaaat atggatataa taaaccacaa 49861 tattaacaac gtaaacacac cgggatattc caggcaggta gcgattcagt cggcatcaaa 49921 ccccatatcg ctccttaacg gaacgggaat gctgggtaca ggctcggaag tgcttgccat 49981 tgaaagaata agggatgaat accttgatta caagtactgg agtgaaaaca tttcttacgg 50041 agaatggaat gccaaaagga ctcttcttgc cgatatggaa gttacattca atgaaccgtc 50101 ggacagcgga tttaatgctg tgataaacag tttttacaat tctttgcagg aacttgcaaa 50161 agaccccagc agcgatgcga tcagggcttt ggtaaaagaa cagggcgtaa cctttgcgcg 50221 ctactttaac aacattgcat cccattttga agagcttcag tttgatataa acaatcaggt 50281 aaagactgtt gttaccgaga taaactcatt aggcactcaa atagcccagt tgaacaagca 50341 aatatacact gccgagctgg acggaaatac tgcaaatgac ttaagagaca aaaggacact 50401 tttgattgat gagctttcaa agcttgtaaa catagatgtc aacgaagtag tggtgggcaa 50461 actccccaac ggcaaagacg acaaacgaat gataattacg atcagcggaa aggcttttgt 50521 agacaacttt gatgtcaaca agctcactat taagcaaaga gagaataaac tgaatgagga 50581 agaggatatt ccaaatctgt acgaagtttt gtgggaagac ggcaacagcc ttagtgtcag 50641 gggcggagag ctgaaaggac tgcttgatgt tagggatgga aatgacggag aaaacggaag 50701 tcccaactat aaaggcatac cctattacat aaggaaactt aatgaatttg tcaggacttt 50761 tgcaatagca tttaacgaag gaatagtggg aaacgacaag gtggcgggtc atgtggacgg 50821 atatggcacc aacggaaata caggaataag atttttcacc atattgggag aggaaaacaa 50881 acctatatcc agtgctgatt tcatgtccgc cggagatatt gacgcctgct acgggaaaat 50941 gactgccaaa aactttaccg taagtagcga cattctggat gatccaagaa acattgcaac 51001 agctgataca aaggatcagg tcgggaacat aggaaatata aacagtatcc tggctatgag 51061 aaataacgtc catatgttca aggaaggtgc tccggaggac tttgtaaaat ctgttattac 51121 aactctggcg atagattctc agcaaactat aaggctttcg tcaatccata aaaatatgat 51181 tgaacaggtt gaaaatcaga ggatgtctgt gtcaggggtg tctttggacg aagaagtggc 51241 aaatctggta aagcaccatc aggcttatgc ggcggccgca caaatgatta ataccatggc 51301 ggaagtttac gacatactga ttaacagagt aggtctttga gattagaggt atttagtcca 51361 tgcagtaacg gaggggtaat atgagaataa ccaataatat gattgtaaac aatatgatta 51421 acaatattgg aaaaaacctc gcaagaatgg acaagtatca gcagatgctg gccaccggca 51481 agaaaattac cgttccttcg gatgacccgg tggttgcggc cagggcgctg aaacttcgta 51541 ccgacgtggc tcagatagaa cagtacaaaa caaatgtgca ggatgcaatg tcatggctgg 51601 aaattaccga gtcggctgtc gcaaatgtgg gtgacatatt gcaaagggcg agggaactgg 51661 ctgtgcaggc aagcagtggt accaccaccg aggaggatac aaagaaaata aagcaggaag 51721 tggagcagct gaaaaaccag ctgataaaaa ttgcgaattc cacatatgcc ggaagataca 51781 tattttcagg attcaaaaca aatacaaggc ttatggatga tgacggttat tttacaatgg 51841 acgttgcaaa cagcgaagca ataatttatc agataggaat aagtgacagt ataaatataa 51901 atgtgccggg aggagatctg tttaacggcg gaattgatgc cggcgccggt ggaaaaggca 51961 agcttattgc ggacttcgaa gcttacataa atgcactcga ttcaggagat cattcgctta 52021 taagtgatgc gataacaaat attgacgaga atttaaacca tgtgcttaga atacgggcgg 52081 atatcggtgc cagatacaac cgccttgagt tgactgcgga caggcttgat atagattcca 52141 tcaactttag aaagcttatg agtgaaaatg aggatgtgga tcaggctgaa aacatattgc 52201 ttttaaagac tgaggaaaat gtttacaggg catcattgtc cggtggagca agaataatac 52261 agacatccct tgtcgacttt ttgaaataag tctgcaatac tcgattaaca caaggttaga 52321 gtgggtggta atatgggtat tattataaca caaacccatg ccagaatcgg tattgacaga 52381 acctattcaa aaatggagat tgagactcaa aatgcccggt ttaagcttca tcaaaatcat 52441 gcgaaagtgg aaatagaaac tgagcttccc aaaatcgaga ttgaccagta tgaagctttt 52501 gcaagcgccg ggcttaaaaa ccatctggat ttggcaaggg aaatagcgca aaaagggcgt 52561 cagaatgcat taagatacat cgggaaagtg gccgatgacg gagatgccct ggctgctatt 52621 gaaaacggag ggaatttgat tccggagctt gcaaagaggg attcatacaa gacccacgaa 52681 tttaacattg acgccattcc aaaagcaagt cccaaggttt cagtgagcgg aggactggaa 52741 attgatttcc cgcaagacta ccggaggatc atccacaacg gtgtcgaagg aatctttatt 52801 ccgccgtatt ttgatttgaa atacactccg gagaaaataa aaatatattt ggaacaatat 52861 gcatcaataa aaattgacta tgtggagaat aaaatcgata catatgtgta aactgtagat 52921 gaaaatgtgg aggagataaa atgcttctta aaaccaaaca ctttggagaa ataaatattg 52981 atgaaagtaa aattattgaa tttaaagacg gaatacccgg gtttgaaaac ttgaaacggt 53041 atgtggtatt atatgacgga gacaagaatt caccgtttag atggcttcag aatgttgatg 53101 acggagagct tgcctttgca gtggttaatc cttttatggt tgttaaggat tacgattttg 53161 aaatacccga tgaggctgtt gaaagtcttg gtatcgaaag tattctggat gtgatggtgc 53221 tttcgatagt tgtcgtcccg gaggatattt cgaaaatgac tatgaatttg aaggctcctg 53281 tcattataaa cacaaaaaat aataaaggta tgcaagttgt ccttgacacg gatagatata 53341 gtgtgagaca ctatataata gaagagctcc ggagacagga ggtaaatgta ggtgctggtt 53401 ctgacgagaa agaaaaatga atccataatt attaatgaca atattgagat tactgttgtt 53461 gacgttcaag gggagcaggt gcgtatcggc attaatgcgc cgaaaagcat atctatttac 53521 aggaaggaga tatacctgga aatacaggct gaaaacaaaa aggctgcgga aattaagaat 53581 gtggatctga aggaggactt aaaggatttt ttgaagtaaa tgttacaagt gaatacggtt 53641 tttgaggaag tggcgatgtg accacttttt ttattgccga aatttccggt gtgatttttg 53701 taattcgcaa tacttaatgt aaaatcatta taaaaagatt caataatgga aagataaagg 53761 agttaaggta aaaaataaac ttaataaata acttaacttt aagataaaaa ataggttttg 53821 aggtgctatt atggcggaaa atcatgacta tgagagagaa ataaacagat tgtttgaatt 53881 gcagaagaaa aacgttgtac ggcttcgcac atcgagtata gatgagagaa ttgcgaaact 53941 gaaaaaattg aaagaatata tttgggaaaa taaagaaaag attcaggagg cggtttataa 54001 cgatttgaga aagcctccgg aggaggtttt attaaccgaa atatatcctg ttgtctcgga 54061 aatcaggcat gtaataaaga atttgaaaaa atggacaaag cctaagaaag tcagaacacc 54121 catatctctt tttggggcaa aaagctatta cagatttgag gcaaaagggg tggtgctgat 54181 tatttcaccg tggaactatc cctttgaact ctcaataggc ccgttaatca ctgccattgc 54241 tgccgggaat gcggttgtat tgaagccttc ggaattgagt ccccatacat ccggttatat 54301 aaagaaactt gtggcagaca tttttgatga aagtgaggtt gctgttgttg aaggggatgc 54361 ggtggtggcc caaaaactgc tggagatggg ttttaatcat atatttttta ccggaagtac 54421 aaaggttgcg aaagctgtgc taaagaaggc ctctgagaca ttgtcttcgg taacccttga 54481 actaggagga aaaagtccgg taattattga cggcaaattt gatattgaag aggctgctaa 54541 aaaaataaca tggggtaaat atttaaatgc agggcagaca tgcatagctc cggattacgt 54601 ttttgtaaaa aaagagcttt tagg //