/* $Id: $ * =========================================================================== * * PUBLIC DOMAIN NOTICE * National Center for Biotechnology Information * * This software/database is a "United States Government Work" under the * terms of the United States Copyright Act. It was written as part of * the author's offical duties as a United States Government employee and * thus cannot be copyrighted. This software/database is freely available * to the public for use. The National Library of Medicine and the U.S. * Government have not placed any restriction on its use or reproduction. * * Although all reasonable efforts have been taken to ensure the accuracy * and reliability of the software and data, the NLM and the U.S. * Government do not and cannot warrant the performance or results that * may be obtained by using this software or data. The NLM and the U.S. * Government disclaim all warranties, express or implied, including * warranties of performance, merchantability or fitness for any particular * purpose. * * Please cite the author in any work or product based on this material. * * ===========================================================================*/ /***************************************************************************** File name: sls_alp_sim.cpp Author: Sergey Sheetlin Contents: Calculation of Gumbel parameters ******************************************************************************/ #include "sls_alp_sim.hpp" using namespace Sls; using namespace std; static bool calculate_C_S_constant_flag=true; static double dbl_max_log=log(DBL_MAX); alp_sim::alp_sim(//constructor alp_data *alp_data_) { d_alp_obj=NULL; d_lambda_tmp=NULL; d_lambda_tmp_errors=NULL; d_C_tmp=NULL; d_C_tmp_errors=NULL; d_alp_data=alp_data_; ofstream frand; try { if(!d_alp_data) { throw error("Unexpected error\n",4); }; d_alp_obj=new array_positive (d_alp_data); alp_data::assert_mem(d_alp_obj); d_n_alp_obj=0; d_alp_data->d_memory_size_in_MB+=(double)(sizeof(array_positive))/mb_bytes; double memory_before1=d_alp_data->d_memory_size_in_MB; double time_before1; alp_data::get_current_time(time_before1); d_alp_data->d_time_before1=time_before1; if(!d_alp_data->d_rand_flag) { d_alp_data->d_rand_all->d_random_seed=d_alp_data->d_random_seed; }; //trial simulation for estimation time and memory long int M_min; long int nalp; double time_after_tmp; d_lambda_tmp=new array_positive(d_alp_data); alp_data::assert_mem(d_lambda_tmp); d_lambda_tmp_errors=new array_positive(d_alp_data); alp_data::assert_mem(d_lambda_tmp_errors); d_C_tmp=new array_positive(d_alp_data); alp_data::assert_mem(d_C_tmp); d_C_tmp_errors=new array_positive(d_alp_data); alp_data::assert_mem(d_C_tmp_errors); //quick tests quick_test( quick_tests_trials_number, d_alp_data->d_max_time_for_quick_tests); long int maximum_number_of_realizations_for_preliminary_simulation=1000; bool loop_break_flag; long int rand_i=-1; bool lambda_accuracy_flag=true; long int sim_number=1; do{ long int nalp_lambda; bool C_calculation=false; long int number_tmp; bool check_time_flag=true; if(d_alp_data->d_rand_flag) { check_time_flag=false; rand_i++; number_tmp=d_alp_data->d_rand_all->d_first_stage_preliminary_realizations_numbers_ALP[rand_i]; } else { number_tmp=alp_data::Tmin(maximum_number_of_realizations_for_preliminary_simulation-1,d_n_alp_obj+sim_number*d_alp_data->d_minimum_realizations_number-1); }; get_minimal_simulation( 0, number_tmp, M_min, nalp, nalp_lambda, C_calculation, check_time_flag); if(!d_alp_data->d_rand_flag) { d_alp_data->d_rand_all->d_first_stage_preliminary_realizations_numbers_ALP.push_back(number_tmp); }; sim_number*=2; if(d_lambda_tmp->d_elem[nalp]>=0) { if(d_lambda_tmp_errors->d_elem[nalp]/d_lambda_tmp->d_elem[nalp]d_eps_lambda) { lambda_accuracy_flag=false; }; }; alp_data::get_current_time(time_after_tmp); if(number_tmp>=maximum_number_of_realizations_for_preliminary_simulation-1) { if(!d_alp_data->d_rand_flag) { break; }; }; if(d_alp_data->d_rand_flag) { loop_break_flag=(rand_i>=(long int)(d_alp_data->d_rand_all->d_first_stage_preliminary_realizations_numbers_ALP.size()-1)); } else { loop_break_flag=!(maximum_number_of_realizations_for_preliminary_simulation>d_n_alp_obj-1&& lambda_accuracy_flag&&((time_after_tmp-time_before1)<=0||((time_after_tmp-time_before1)<0.01*d_alp_data->d_max_time&&d_alp_data->d_memory_size_in_MBd_max_mem))); }; } while(!loop_break_flag); double memory_after1=d_alp_data->d_memory_size_in_MB; double time_after1; alp_data::get_current_time(time_after1); if(memory_after1<=memory_before1) { delete d_alp_obj;d_alp_obj=NULL; throw error("Unexpected error\n",4); }; long int limit_by_memory=(long int)alp_data::Tmin((double)LONG_MAX-1,alp_data::round(d_alp_data->d_max_mem/2.0/(memory_after1-memory_before1)*d_n_alp_obj)); if(d_alp_data->d_memory_size_in_MB>d_alp_data->d_max_mem) { //cout<<"\nWarning: memory limit is reached.\nTo get the requested accuracy please\nincrease maximum allowed amount of memory if possible\n\n"; }; long int limit_by_time; if(time_after1<=time_before1) { limit_by_time=LONG_MAX; } else { limit_by_time=(long int)alp_data::Tmin((double)LONG_MAX-1,alp_data::round(d_alp_data->d_max_time/3.0/4.0/(time_after1-time_before1)*d_n_alp_obj)); }; long int realizations_number2=alp_data::Tmin((long int)alp_data::round(limit_by_time)-1,limit_by_memory-1); realizations_number2=alp_data::Tmin(maximum_number_of_realizations_for_preliminary_simulation-(long int)1,realizations_number2); realizations_number2=alp_data::Tmax(d_n_alp_obj-(long int)1,realizations_number2); delete d_lambda_tmp;d_lambda_tmp=NULL; delete d_lambda_tmp_errors;d_lambda_tmp_errors=NULL; delete d_C_tmp;d_C_tmp=NULL; delete d_C_tmp_errors;d_C_tmp_errors=NULL; //trial simulation for estimation M_min and nalp d_lambda_tmp=new array_positive(d_alp_data); alp_data::assert_mem(d_lambda_tmp); d_lambda_tmp_errors=new array_positive(d_alp_data); alp_data::assert_mem(d_lambda_tmp_errors); d_C_tmp=new array_positive(d_alp_data); alp_data::assert_mem(d_C_tmp); d_C_tmp_errors=new array_positive(d_alp_data); alp_data::assert_mem(d_C_tmp_errors); long int nalp_lambda; bool C_calculation=false; double lambda; double eps_K=d_alp_data->d_eps_K; double K_C; double K_C_error; long int level; long int diff_opt; rand_i=-1; loop_break_flag=false; double time_before_ALP; double time_during_ALP; long int number_of_realizations_with_ALP=alp_data::Tmin(realizations_number2,d_n_alp_obj-(long int)1+d_alp_data->d_minimum_realizations_number); long int number_of_realizations_with_ALP_pred; alp_data::get_current_time(time_before_ALP); do{ bool check_time_flag=true; if(d_alp_data->d_rand_flag) { check_time_flag=false; rand_i++; number_of_realizations_with_ALP=d_alp_data->d_rand_all->d_preliminary_realizations_numbers_ALP[rand_i]; }; get_minimal_simulation( 0, number_of_realizations_with_ALP, M_min, nalp, nalp_lambda, C_calculation, check_time_flag); if(!d_alp_data->d_rand_flag) { d_alp_data->d_rand_all->d_preliminary_realizations_numbers_ALP.push_back(number_of_realizations_with_ALP); }; lambda=d_lambda_tmp->d_elem[nalp]; double tmp_lambda=2.0; if(d_lambda_tmp->d_elem[nalp]>0) { tmp_lambda=((d_lambda_tmp_errors->d_elem[nalp]/d_lambda_tmp->d_elem[nalp])/d_alp_data->d_eps_lambda); }; number_of_realizations_with_ALP_pred=number_of_realizations_with_ALP; alp_data::get_current_time(time_during_ALP); if(d_alp_data->d_rand_flag) { loop_break_flag=(rand_i>=(long int)(d_alp_data->d_rand_all->d_preliminary_realizations_numbers_ALP.size()-1)); if(loop_break_flag) { break; }; }; if(time_during_ALP-time_before1>=d_alp_data->d_max_time*0.25||number_of_realizations_with_ALP>=realizations_number2||tmp_lambda<=1.0) { if(!d_alp_data->d_rand_flag) { break; }; }; if(time_during_ALP<=time_before_ALP) { number_of_realizations_with_ALP=alp_data::Tmin(realizations_number2,number_of_realizations_with_ALP+d_alp_data->d_minimum_realizations_number); } else { long int max_number_of_realizations=(long int)floor(number_of_realizations_with_ALP*(d_alp_data->d_max_time*0.35-(time_before_ALP-time_before1))/(time_during_ALP-time_before_ALP)); number_of_realizations_with_ALP=alp_data::Tmin(realizations_number2,(long int)floor(0.5*number_of_realizations_with_ALP+0.5*max_number_of_realizations)); if(number_of_realizations_with_ALP>=max_number_of_realizations) { number_of_realizations_with_ALP=d_alp_data->Tmin(realizations_number2,number_of_realizations_with_ALP+d_alp_data->d_minimum_realizations_number); }; if((double)(number_of_realizations_with_ALP-number_of_realizations_with_ALP_pred)/(double)number_of_realizations_with_ALP_pred<0.005) { number_of_realizations_with_ALP=number_of_realizations_with_ALP_pred; if(!d_alp_data->d_rand_flag) { break; }; }; }; } while(!loop_break_flag); realizations_number2=number_of_realizations_with_ALP; long int realizations_number2_lambda=number_of_realizations_with_ALP; rand_i=-1; loop_break_flag=false; double time_before_kill; double time_during_kill; long int number_of_realizations_with_killing=d_alp_data->Tmin(realizations_number2,d_alp_data->d_minimum_realizations_number-(long int)1); long int number_of_realizations_with_killing_pred; alp_data::get_current_time(time_before_kill); do{ bool check_time_flag=false; if(d_alp_data->d_rand_flag) { check_time_flag=false; rand_i++; number_of_realizations_with_killing=d_alp_data->d_rand_all->d_preliminary_realizations_numbers_killing[rand_i]; }; kill( check_time_flag, 0, number_of_realizations_with_killing, M_min, lambda, eps_K, K_C, K_C_error, level, diff_opt); if(!d_alp_data->d_rand_flag) { d_alp_data->d_rand_all->d_preliminary_realizations_numbers_killing.push_back(number_of_realizations_with_killing); }; number_of_realizations_with_killing_pred=number_of_realizations_with_killing; alp_data::get_current_time(time_during_kill); double tmp_K=2.0; if(K_C>0) { tmp_K=((K_C_error/K_C)/d_alp_data->d_eps_K); }; if(d_alp_data->d_rand_flag) { loop_break_flag=(rand_i>=(long int)(d_alp_data->d_rand_all->d_preliminary_realizations_numbers_killing.size()-1)); if(loop_break_flag) { break; }; }; if(time_during_kill-time_before1>=d_alp_data->d_max_time||number_of_realizations_with_killing>=realizations_number2||tmp_K<=1.0) { if(!d_alp_data->d_rand_flag) { break; }; }; if(time_during_kill<=time_before_kill) { number_of_realizations_with_killing=d_alp_data->Tmin(realizations_number2,number_of_realizations_with_killing+d_alp_data->d_minimum_realizations_number); } else { long int max_number_of_realizations=(long int)floor(number_of_realizations_with_killing*(d_alp_data->d_max_time-(time_before_kill-time_before1))/(time_during_kill-time_before_kill)); number_of_realizations_with_killing=d_alp_data->Tmin(realizations_number2,(long int)floor(0.5*number_of_realizations_with_killing+0.5*max_number_of_realizations)); if(number_of_realizations_with_killing>=max_number_of_realizations) { number_of_realizations_with_killing=d_alp_data->Tmin(realizations_number2,number_of_realizations_with_killing+d_alp_data->d_minimum_realizations_number); }; if((double)(number_of_realizations_with_killing-number_of_realizations_with_killing_pred)/(double)number_of_realizations_with_killing_pred<0.005) { number_of_realizations_with_killing=number_of_realizations_with_killing_pred; if(!d_alp_data->d_rand_flag) { break; }; }; }; } while(!loop_break_flag); long int k; for(k=0;k<=number_of_realizations_with_killing;k++) { d_alp_obj->d_elem[k]->partially_release_memory(); }; realizations_number2=number_of_realizations_with_killing; long int realizations_number2_K=number_of_realizations_with_killing; d_alp_data->d_realizations_number2=realizations_number2_lambda; if(K_C<=0) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; double tmp=((K_C_error/K_C)/d_alp_data->d_eps_K); tmp=alp_data::Tmin(ceil((realizations_number2_K+1)*tmp*tmp),(double)LONG_MAX); long int realizations_number_killing=(long int)tmp; tmp=((d_lambda_tmp_errors->d_elem[nalp]/d_lambda_tmp->d_elem[nalp])/d_alp_data->d_eps_lambda); tmp=alp_data::Tmin(ceil((realizations_number2_lambda+1)*tmp*tmp),(double)LONG_MAX); long int realizations_number_lambda=(long int)tmp; double time_after2; alp_data::get_current_time(time_after2); time_after2=alp_data::Tmax(time_after2,time_after_tmp); delete d_lambda_tmp;d_lambda_tmp=NULL; delete d_lambda_tmp_errors;d_lambda_tmp_errors=NULL; delete d_C_tmp;d_C_tmp=NULL; delete d_C_tmp_errors;d_C_tmp_errors=NULL; //main simulation long int j; j=1; long int kill_j=0; bool kill_flag=(realizations_number_killing>realizations_number2_K+1+j); bool lambda_flag=(realizations_number_lambda>realizations_number2_lambda+1+j); long int nalp_for_simulation=nalp; //!!!!!!!!!!!!!!!!!!!!!!! //cout<<"A number of ALPs\t"<d_rand_flag) { lambda_flag=(d_alp_data->d_rand_all->d_total_realizations_number_with_ALP>realizations_number2_K+j-1); kill_flag=(d_alp_data->d_rand_all->d_total_realizations_number_with_killing>realizations_number2_K+j-1); }; if(kill_flag||lambda_flag) { long int step_for_time=1; //long int number_of_unsuccesful_objects=0; //!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! //cout<<"M_min="<realizations_number2_K+j); lambda_flag=(realizations_number_lambda>realizations_number2_lambda+j); if(d_alp_data->d_rand_flag) { lambda_flag=(d_alp_data->d_rand_all->d_total_realizations_number_with_ALP>realizations_number2_K+j-1); kill_flag=(d_alp_data->d_rand_all->d_total_realizations_number_with_killing>realizations_number2_K+j-1); }; if(!(kill_flag||lambda_flag)) { if(!d_alp_data->d_rand_flag) { //cout<<"\nThe parameters were calculated with the required accuracy\n\n"; break; } else { break; }; }; if(!kill_flag) { nalp_for_simulation=alp_data::Tmin(nalp_lambda,nalp); }; bool sucess_flag=false; if(realizations_number2_K+j<=realizations_number2_lambda) { } else { d_alp_obj->set_elem(realizations_number2_K+j,NULL); d_n_alp_obj++; }; alp *&obj=d_alp_obj->d_elem[realizations_number2_K+j]; try { double eps_tmp; while(!sucess_flag) { bool check_time_flag=true; if(d_alp_data->d_rand_flag) { check_time_flag=false; }; get_single_realization( check_time_flag, M_min, nalp_for_simulation, kill_flag, level, diff_opt, obj, sucess_flag, eps_tmp); if(!sucess_flag) { if(realizations_number2_K+j>realizations_number2_lambda) { d_n_alp_obj--; }; //number_of_unsuccesful_objects++; // if(number_of_unsuccesful_objects>/*5+*/0.5*alp_data::Tmin(d_alp_data->d_rand_all->d_total_realizations_number_with_killing,d_alp_data->d_rand_all->d_total_realizations_number_with_ALP)*eps_tmp) // { //if(realizations_number2_K+j>realizations_number2_lambda) //{ // d_n_alp_obj--; //}; //throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); // }; }; }; } catch (error_for_single_realization er) { if(d_alp_data->d_rand_flag) { throw error("Unexpected error in ramdomization\n",4); }; //cout<<"\nWarning: time limit is reached.\nTo get the requested accuracy please\nincrease the allowed calculation time if possible\n\n"; if(realizations_number2_K+j>realizations_number2_lambda) { delete obj;obj=NULL; d_n_alp_obj--; }; break; }; if(realizations_number2_K+j>realizations_number2_lambda) { if(kill_flag) { kill_j=j; }; }; d_alp_obj->d_elem[realizations_number2_K+j]->partially_release_memory(); j++; if(d_alp_data->d_memory_size_in_MB>d_alp_data->d_max_mem) { if(!d_alp_data->d_rand_flag) { //cout<<"\nWarning: memory limit is reached.\nTo get the requested accuracy please\nincrease the allowed amount of memory if possible\n\n"; break; }; }; if(j%step_for_time==0) { double time_after3; alp_data::get_current_time(time_after3); if((time_after3-time_before1)>d_alp_data->d_max_time) { if(!d_alp_data->d_rand_flag) { //cout<<"\nWarning: time limit is reached.\nTo get the requested accuracy please\nincrease the allowed calculation time if possible\n\n"; break; }; }; }; }; } else { //cout<<"\nThe parameters were calculated with required accuracy\n\n"; }; long int final_realizations_number_killing=kill_j+realizations_number2_K+1; long int final_realizations_number_lambda=alp_data::Tmax(realizations_number2_lambda+1,j+realizations_number2_K); d_n_alp_obj=final_realizations_number_lambda; double time_after100; alp_data::get_current_time(time_after100); //cout<<"\nActual calculation time is "<Tmax(memory_after2,memory_after3)<<" MBs\n\n"; if(!d_alp_data->d_rand_flag) { d_alp_data->d_rand_all->d_total_realizations_number_with_ALP=final_realizations_number_lambda-1; d_alp_data->d_rand_all->d_total_realizations_number_with_killing=final_realizations_number_killing-1; }; //!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! //output of a file with complete randomization information if(!d_alp_data->d_rand_flag&&d_alp_data->d_randout!="") { //string rand_st="rand_"+alp_data::long_to_string(d_alp_data->d_rand_all->d_random_factor)+".out"; string rand_st=d_alp_data->d_randout; frand.open(rand_st.data(),ios::out); if(!frand) { throw error("Error - file "+rand_st+" cannot be created\n",3); }; long int i; frand<d_rand_all->d_random_seed<d_rand_all->d_first_stage_preliminary_realizations_numbers_ALP.size()<<"\t"; for(i=0;i<(long int)d_alp_data->d_rand_all->d_first_stage_preliminary_realizations_numbers_ALP.size();i++) { frand<d_rand_all->d_first_stage_preliminary_realizations_numbers_ALP[i]<<"\t"; }; frand<d_rand_all->d_preliminary_realizations_numbers_ALP.size()<<"\t"; for(i=0;i<(long int)d_alp_data->d_rand_all->d_preliminary_realizations_numbers_ALP.size();i++) { frand<d_rand_all->d_preliminary_realizations_numbers_ALP[i]<<"\t"; }; frand<d_rand_all->d_preliminary_realizations_numbers_killing.size()<<"\t"; for(i=0;i<(long int)d_alp_data->d_rand_all->d_preliminary_realizations_numbers_killing.size();i++) { frand<d_rand_all->d_preliminary_realizations_numbers_killing[i]<<"\t"; }; frand<d_rand_all->d_total_realizations_number_with_ALP<d_rand_all->d_total_realizations_number_with_killing<d_rand_all->d_total_realizations_number_with_ALP<m_CalcTime=time_after100-time_before1; output_main_parameters2m_new( nalp_for_simulation, level, inside_simulation_flag, final_realizations_number_lambda, final_realizations_number_killing); } catch (...) { delete d_lambda_tmp;d_lambda_tmp=NULL; delete d_lambda_tmp_errors;d_lambda_tmp_errors=NULL; delete d_C_tmp;d_C_tmp=NULL; delete d_C_tmp_errors;d_C_tmp_errors=NULL; this->~alp_sim(); if(frand.is_open()) { frand.close(); }; throw; }; } void alp_sim::symmetric_parameters_for_symmetric_scheme() { //check whether the scoring scheme is symmetric bool symmetric_flag=true; long int i,j; for(i=0;id_number_of_AA;i++) { for(j=0;jd_smatr[i][j]!=d_alp_data->d_smatr[j][i]) { symmetric_flag=false; break; }; }; if(!symmetric_flag) { break; }; }; if(symmetric_flag) { for(i=0;id_number_of_AA;i++) { if(d_alp_data->d_RR1[i]!=d_alp_data->d_RR2[i]) { symmetric_flag=false; break; }; }; }; if(symmetric_flag) { if(d_alp_data->d_epen1!=d_alp_data->d_epen2||d_alp_data->d_open1!=d_alp_data->d_open2) { symmetric_flag=false; }; }; if(symmetric_flag) { m_AI=0.5*(m_AI+m_AJ); m_AJ=m_AI; m_AIError=0.5*(m_AIError+m_AJError); m_AJError=m_AIError; m_AlphaI=0.5*(m_AlphaI+m_AlphaJ); m_AlphaJ=m_AlphaI; m_AlphaIError=0.5*(m_AlphaIError+m_AlphaJError); m_AlphaJError=m_AlphaIError; }; } void alp_sim::randomize_realizations( long int final_realizations_number_lambda_, long int final_realizations_number_killing_) { randomize_realizations_ind(0,final_realizations_number_killing_-1); randomize_realizations_ind(final_realizations_number_killing_,final_realizations_number_lambda_-1); } void alp_sim::randomize_realizations_ind( long int ind1_, long int ind2_) { alp**array_ind=NULL; long int *perm=NULL; try { if(ind1_>=ind2_) { return; }; if(ind2_>d_n_alp_obj-1) { throw error("Unexpected error\n",4); }; long int total_number=ind2_-ind1_+1; array_ind=new alp*[total_number]; alp_data::assert_mem(array_ind); perm=new long int [total_number]; alp_data::assert_mem(perm); generate_random_permulation(perm,total_number); long int i; for(i=0;id_elem[ind1_+perm[i]]; }; for(i=0;id_elem[ind1_+i]=array_ind[i]; }; delete[]array_ind;array_ind=NULL; delete[]perm;perm=NULL; } catch (...) { delete[]array_ind;array_ind=NULL; delete[]perm;perm=NULL; throw; }; } void alp_sim::generate_random_permulation( long int *perm_, long int dim_) { long int i; for(i=0;iran2(),dim_-i); long int tmp=perm_[ind_swap]; perm_[ind_swap]=perm_[i]; perm_[i]=tmp; }; } void alp_sim::output_main_parameters2m_new( long int nalp_for_lambda_simulation, long int level, bool &inside_simulation_flag, long int final_realizations_number_lambda_, long int final_realizations_number_killing_) { double lambda; double lambda_error; double test_difference; double test_difference_error; double C; double C_error; double K_C; double K_C_error; double a_I; double a_I_error; double a_J; double a_J_error; double sigma; double sigma_error; double alpha_I; double alpha_I_error; double alpha_J; double alpha_J_error; double K; double K_error; bool flag=false; long int number_of_trials=0; long int number_of_trials_threshold=4; do{ calculate_main_parameters2m( final_realizations_number_lambda_, final_realizations_number_killing_, nalp_for_lambda_simulation, level, inside_simulation_flag, lambda, lambda_error, test_difference, test_difference_error, C, C_error, K_C, K_C_error, a_I, a_I_error, a_J, a_J_error, sigma, sigma_error, alpha_I, alpha_I_error, alpha_J, alpha_J_error, K, K_error, flag); number_of_trials++; if(!flag) { randomize_realizations( final_realizations_number_lambda_, final_realizations_number_killing_); //cout<<"Randomization attempt\t"<*)alp_distr[j];alp_distr[j]=NULL; }; delete[]alp_distr;alp_distr=NULL; }; if(alp_distr_errors) { long int j; for(j=1;j<=nalp_for_lambda_simulation;j++) { delete (array_positive*)alp_distr_errors[j];alp_distr_errors[j]=NULL; }; delete[]alp_distr_errors;alp_distr_errors=NULL; }; if(alp_mult_distr) { long int k,j; for(k=1;k<=d_mult_number;k++) { if(alp_mult_distr[k]) { for(j=1;j<=nalp_for_lambda_simulation;j++) { delete (array_positive*)alp_mult_distr[k][j];alp_mult_distr[k][j]=NULL; }; delete[]alp_mult_distr[k];alp_mult_distr[k]=NULL; }; }; delete[]alp_mult_distr;alp_mult_distr=NULL; }; if(alp_mult_distr_errors) { long int k,j; for(k=1;k<=d_mult_number;k++) { if(alp_mult_distr_errors[k]) { for(j=1;j<=nalp_for_lambda_simulation;j++) { delete (array_positive*)alp_mult_distr_errors[k][j];alp_mult_distr_errors[k][j]=NULL; }; delete[]alp_mult_distr_errors[k];alp_mult_distr_errors[k]=NULL; }; }; delete[]alp_mult_distr_errors;alp_mult_distr_errors=NULL; }; delete[]d_mult_realizations;d_mult_realizations=NULL; delete[]d_mult_K_realizations;d_mult_K_realizations=NULL; delete[]lambda_mult;lambda_mult=NULL; delete[]lambda_mult_error;lambda_mult_error=NULL; delete[]C_mult;C_mult=NULL; delete[]C_mult_error;C_mult_error=NULL; delete[]a_I_mult;a_I_mult=NULL; delete[]a_I_mult_error;a_I_mult_error=NULL; delete[]a_J_mult;a_J_mult=NULL; delete[]a_J_mult_error;a_J_mult_error=NULL; delete[]sigma_mult;sigma_mult=NULL; delete[]sigma_mult_error;sigma_mult_error=NULL; delete[]alpha_I_mult;alpha_I_mult=NULL; delete[]alpha_I_mult_error;alpha_I_mult_error=NULL; delete[]alpha_J_mult;alpha_J_mult=NULL; delete[]alpha_J_mult_error;alpha_J_mult_error=NULL; delete[]K_C_mult;K_C_mult=NULL; delete[]K_C_mult_error;K_C_mult_error=NULL; delete[]K_mult;K_mult=NULL; delete[]K_mult_error;K_mult_error=NULL; delete[]Sc_mult;Sc_mult=NULL; delete[]Sc_mult_error;Sc_mult_error=NULL; } void alp_sim::calculate_main_parameters2m( long int final_realizations_number_lambda_, long int final_realizations_number_killing_, long int nalp_for_lambda_simulation, long int level, bool &inside_simulation_flag, double &lambda, double &lambda_error, double &test_difference, double &test_difference_error, double &C, double &C_error, double &K_C, double &K_C_error, double &a_I, double &a_I_error, double &a_J, double &a_J_error, double &sigma, double &sigma_error, double &alpha_I, double &alpha_I_error, double &alpha_J, double &alpha_J_error, double &K, double &K_error, bool &flag_) { long int *d_mult_realizations=NULL; long int *d_mult_K_realizations=NULL; double *lambda_mult=NULL; double *lambda_mult_error=NULL; double *C_mult=NULL; double *C_mult_error=NULL; double *a_I_mult=NULL; double *a_I_mult_error=NULL; double *a_J_mult=NULL; double *a_J_mult_error=NULL; double *sigma_mult=NULL; double *sigma_mult_error=NULL; double *alpha_I_mult=NULL; double *alpha_I_mult_error=NULL; double *alpha_J_mult=NULL; double *alpha_J_mult_error=NULL; double *K_C_mult=NULL; double *K_C_mult_error=NULL; double *K_mult=NULL; double *K_mult_error=NULL; double *Sc_mult=NULL; double *Sc_mult_error=NULL; void **alp_distr=NULL; void **alp_distr_errors=NULL; void ***alp_mult_distr=NULL; void ***alp_mult_distr_errors=NULL; try { flag_=false; if(final_realizations_number_killing_>final_realizations_number_lambda_) { throw error("Unexpected error\n",4); }; long int mult_number_lambda=get_number_of_subsimulations(d_n_alp_obj); long int mult_number_K=get_number_of_subsimulations(final_realizations_number_killing_); //!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! //mult_number_lambda=mult_number_K=final_realizations_number_killing_; d_mult_number=alp_data::Tmin(mult_number_lambda,mult_number_K); double mult_number_double_lambda=mult_number_lambda; double mult_number_double_K=mult_number_lambda; long int j; d_mult_realizations=new long int[d_mult_number+1]; alp_data::assert_mem(d_mult_realizations); d_mult_K_realizations=new long int[d_mult_number+1]; alp_data::assert_mem(d_mult_K_realizations); lambda_mult=new double[d_mult_number+1]; alp_data::assert_mem(lambda_mult); lambda_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(lambda_mult_error); C_mult=new double[d_mult_number+1]; alp_data::assert_mem(C_mult); C_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(C_mult_error); a_I_mult=new double[d_mult_number+1]; alp_data::assert_mem(a_I_mult); a_I_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(a_I_mult_error); a_J_mult=new double[d_mult_number+1]; alp_data::assert_mem(a_J_mult); a_J_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(a_J_mult_error); sigma_mult=new double[d_mult_number+1]; alp_data::assert_mem(sigma_mult); sigma_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(sigma_mult_error); alpha_I_mult=new double[d_mult_number+1]; alp_data::assert_mem(alpha_I_mult); alpha_I_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(alpha_I_mult_error); alpha_J_mult=new double[d_mult_number+1]; alp_data::assert_mem(alpha_J_mult); alpha_J_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(alpha_J_mult_error); K_C_mult=new double[d_mult_number+1]; alp_data::assert_mem(K_C_mult); K_C_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(K_C_mult_error); K_mult=new double[d_mult_number+1]; alp_data::assert_mem(K_mult); K_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(K_mult_error); Sc_mult=new double[d_mult_number+1]; alp_data::assert_mem(Sc_mult); Sc_mult_error=new double[d_mult_number+1]; alp_data::assert_mem(Sc_mult_error); double lambda_mult2=0; double C_mult2=0; double K_C_mult2=0; double a_I_mult2=0; double a_J_mult2=0; double sigma_mult2=0; double alpha_I_mult2=0; double alpha_J_mult2=0; double K_mult2=0; double Sc_mult2=0; double lambda_mult2_error=0; double C_mult2_error=0; double K_C_mult2_error=0; double a_I_mult2_error=0; double a_J_mult2_error=0; double sigma_mult2_error=0; double alpha_I_mult2_error=0; double alpha_J_mult2_error=0; double K_mult2_error=0; double Sc_mult2_error=0; for(j=0;j<=nalp_for_lambda_simulation;j++) { get_and_allocate_alp_distribution( 0, d_n_alp_obj-1, alp_distr, alp_distr_errors, j); }; alp_mult_distr=new void **[d_mult_number+1]; alp_data::assert_mem(alp_mult_distr); for(j=0;j<=d_mult_number;j++) { alp_mult_distr[j]=NULL; }; alp_mult_distr_errors=new void **[d_mult_number+1]; alp_data::assert_mem(alp_mult_distr_errors); for(j=0;j<=d_mult_number;j++) { alp_mult_distr_errors[j]=NULL; }; alp_mult_distr[0]=alp_distr; alp_mult_distr_errors[0]=alp_distr_errors; long int real_number=(long int)floor((double)final_realizations_number_lambda_/(double)d_mult_number); d_mult_realizations[0]=final_realizations_number_lambda_; long int k; for(k=1;k<=d_mult_number;k++) { d_mult_realizations[k]=real_number; }; long int nr_tmp=0; for(k=1;k<=d_mult_number;k++) { nr_tmp+=d_mult_realizations[k]; long int j; for(j=0;j<=nalp_for_lambda_simulation;j++) { get_and_allocate_alp_distribution( nr_tmp-d_mult_realizations[k], nr_tmp-1, alp_mult_distr[k], alp_mult_distr_errors[k], j); }; }; nr_tmp=0; for(k=1;k<=d_mult_number;k++) { nr_tmp+=d_mult_realizations[k]; long int nalp_tmp; double test_difference; double test_difference_error; calculate_lambda( false, nalp_for_lambda_simulation, nalp_tmp, inside_simulation_flag, alp_mult_distr[k], alp_mult_distr_errors[k], lambda_mult[k], lambda_mult_error[k], test_difference, test_difference_error); if(!inside_simulation_flag) { goto label1; }; lambda_mult2+=lambda_mult[k]; lambda_mult2_error+=lambda_mult[k]*lambda_mult[k]; }; long int nalp_tmp; calculate_lambda( false, nalp_for_lambda_simulation, nalp_tmp, inside_simulation_flag, alp_distr, alp_distr_errors, lambda, lambda_error, test_difference, test_difference_error); if(!inside_simulation_flag) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; lambda_mult[0]=lambda; lambda_mult_error[0]=lambda_error; nr_tmp=0; for(k=1;k<=d_mult_number;k++) { nr_tmp+=d_mult_realizations[k]; calculate_C( 0, nalp_for_lambda_simulation, alp_mult_distr[k], alp_mult_distr_errors[k], lambda_mult[k], lambda_mult_error[k], C_mult[k], C_mult_error[k], Sc_mult[k], Sc_mult_error[k]); C_mult2+=C_mult[k]; C_mult2_error+=C_mult[k]*C_mult[k]; Sc_mult2+=Sc_mult[k]; Sc_mult2_error+=Sc_mult[k]*Sc_mult[k]; }; double Sc; double Sc_error; calculate_C( 0, nalp_for_lambda_simulation, alp_distr, alp_distr_errors, lambda, lambda_error, C, C_error, Sc, Sc_error); C_mult[0]=C; C_mult_error[0]=C_error; Sc_mult[0]=Sc; Sc_mult_error[0]=Sc_error; nr_tmp=0; for(k=1;k<=d_mult_number;k++) { nr_tmp+=d_mult_realizations[k]; calculate_FSC( nalp_for_lambda_simulation, nr_tmp-d_mult_realizations[k], nr_tmp-1, alp_mult_distr[k], lambda_mult[k], Sc_mult[k], //Sc_mult_error[k], a_I_mult[k], a_I_mult_error[k], a_J_mult[k], a_J_mult_error[k], sigma_mult[k], sigma_mult_error[k], alpha_I_mult[k], alpha_I_mult_error[k], alpha_J_mult[k], alpha_J_mult_error[k]); a_I_mult2+=a_I_mult[k]; a_I_mult2_error+=a_I_mult[k]*a_I_mult[k]; a_J_mult2+=a_J_mult[k]; a_J_mult2_error+=a_J_mult[k]*a_J_mult[k]; sigma_mult2+=sigma_mult[k]; sigma_mult2_error+=sigma_mult[k]*sigma_mult[k]; alpha_I_mult2+=alpha_I_mult[k]; alpha_I_mult2_error+=alpha_I_mult[k]*alpha_I_mult[k]; alpha_J_mult2+=alpha_J_mult[k]; alpha_J_mult2_error+=alpha_J_mult[k]*alpha_J_mult[k]; }; calculate_FSC( nalp_for_lambda_simulation, 0, final_realizations_number_lambda_-1, alp_distr, lambda, Sc, //Sc_error, a_I, a_I_error, a_J, a_J_error, sigma, sigma_error, alpha_I, alpha_I_error, alpha_J, alpha_J_error); a_I_mult[0]=a_I; a_I_mult_error[0]=a_I_error; a_J_mult[0]=a_J; a_J_mult_error[0]=a_J_error; sigma_mult[0]=sigma; sigma_mult_error[0]=sigma_error; alpha_I_mult[0]=alpha_I; alpha_I_mult_error[0]=alpha_I_error; alpha_J_mult[0]=alpha_J; alpha_J_mult_error[0]=alpha_J_error; real_number=(long int)floor((double)final_realizations_number_killing_/(double)d_mult_number); d_mult_K_realizations[0]=final_realizations_number_killing_; for(k=1;k<=d_mult_number;k++) { d_mult_K_realizations[k]=real_number; }; //output2 nr_tmp=0; for(k=1;k<=d_mult_number;k++) { nr_tmp+=d_mult_K_realizations[k]; long int recommended_level; long int diff_opt; check_K_criterion_during_killing( nr_tmp-d_mult_K_realizations[k], nr_tmp-1, lambda_mult[k], d_alp_data->d_eps_K, level, recommended_level, diff_opt, K_C_mult[k], K_C_mult_error[k]); K_mult[k]=C_mult[k]*K_C_mult[k]; K_mult_error[k]=alp_data::error_of_the_product( C_mult[k], C_mult_error[k], K_C_mult[k], K_C_mult_error[k]); K_C_mult2+=K_C_mult[k]; K_C_mult2_error+=K_C_mult[k]*K_C_mult[k]; K_mult2+=K_mult[k]; K_mult2_error+=K_mult[k]*K_mult[k]; }; long int recommended_level; long int diff_opt; check_K_criterion_during_killing( 0, final_realizations_number_killing_-1, lambda, d_alp_data->d_eps_K, level, recommended_level, diff_opt, K_C, K_C_error); K=C*K_C; K_error=alp_data::error_of_the_product( C, C_error, K_C, K_C_error); K_C_mult[0]=K_C; K_C_mult_error[0]=K_C_error; K_mult[0]=K; K_mult_error[0]=K_error; lambda_mult2/=d_mult_number; C_mult2/=d_mult_number; K_C_mult2/=d_mult_number; a_I_mult2/=d_mult_number; a_J_mult2/=d_mult_number; sigma_mult2/=d_mult_number; alpha_I_mult2/=d_mult_number; alpha_J_mult2/=d_mult_number; K_mult2/=d_mult_number; lambda_mult2_error/=d_mult_number; C_mult2_error/=d_mult_number; K_C_mult2_error/=d_mult_number; a_I_mult2_error/=d_mult_number; a_J_mult2_error/=d_mult_number; sigma_mult2_error/=d_mult_number; alpha_I_mult2_error/=d_mult_number; alpha_J_mult2_error/=d_mult_number; K_mult2_error/=d_mult_number; mult_number_double_lambda=(double)final_realizations_number_lambda_/(double)real_number; mult_number_double_K=(double)final_realizations_number_killing_/(double)real_number; lambda_mult2_error=alp_reg::sqrt_for_errors(lambda_mult2_error-lambda_mult2*lambda_mult2)/sqrt((double)mult_number_double_lambda); C_mult2_error=alp_reg::sqrt_for_errors(C_mult2_error-C_mult2*C_mult2)/sqrt((double)mult_number_double_lambda); K_C_mult2_error=alp_reg::sqrt_for_errors(K_C_mult2_error-K_C_mult2*K_C_mult2)/sqrt((double)mult_number_double_K); a_I_mult2_error=alp_reg::sqrt_for_errors(a_I_mult2_error-a_I_mult2*a_I_mult2)/sqrt((double)mult_number_double_lambda); a_J_mult2_error=alp_reg::sqrt_for_errors(a_J_mult2_error-a_J_mult2*a_J_mult2)/sqrt((double)mult_number_double_lambda); sigma_mult2_error=alp_reg::sqrt_for_errors(sigma_mult2_error-sigma_mult2*sigma_mult2)/sqrt((double)mult_number_double_lambda); alpha_I_mult2_error=alp_reg::sqrt_for_errors(alpha_I_mult2_error-alpha_I_mult2*alpha_I_mult2)/sqrt((double)mult_number_double_lambda); alpha_J_mult2_error=alp_reg::sqrt_for_errors(alpha_J_mult2_error-alpha_J_mult2*alpha_J_mult2)/sqrt((double)mult_number_double_lambda); K_mult2_error=alp_reg::sqrt_for_errors(K_mult2_error-K_mult2*K_mult2)/sqrt((double)alp_data::Tmin(mult_number_double_lambda,mult_number_double_K)); error_in_calculate_main_parameters2m( lambda, lambda_error, lambda_mult2, lambda_mult2_error); error_in_calculate_main_parameters2m( C, C_error, C_mult2, C_mult2_error); error_in_calculate_main_parameters2m( K_C, K_C_error, K_C_mult2, K_C_mult2_error); error_in_calculate_main_parameters2m( a_I, a_I_error, a_I_mult2, a_I_mult2_error); error_in_calculate_main_parameters2m( a_J, a_J_error, a_J_mult2, a_J_mult2_error); error_in_calculate_main_parameters2m( sigma, sigma_error, sigma_mult2, sigma_mult2_error); error_in_calculate_main_parameters2m( alpha_I, alpha_I_error, alpha_I_mult2, alpha_I_mult2_error); error_in_calculate_main_parameters2m( alpha_J, alpha_J_error, alpha_J_mult2, alpha_J_mult2_error); error_in_calculate_main_parameters2m( K, K_error, K_mult2, K_mult2_error); flag_=true; this->m_AI=a_I; this->m_AIError=a_I_error; this->m_AJ=a_J; this->m_AJError=a_J_error; this->m_Sigma=sigma; this->m_SigmaError=sigma_error; this->m_C=C; this->m_CError=C_error; this->m_K=K; this->m_KError=K_error; this->m_Lambda=lambda; this->m_LambdaError=lambda_error; this->m_AlphaI=alpha_I; this->m_AlphaIError=alpha_I_error; this->m_AlphaJ=alpha_J; this->m_AlphaJError=alpha_J_error; this->m_AISbs.resize(d_mult_number); this->m_AJSbs.resize(d_mult_number); this->m_SigmaSbs.resize(d_mult_number); this->m_CSbs.resize(d_mult_number); this->m_KSbs.resize(d_mult_number); this->m_LambdaSbs.resize(d_mult_number); this->m_AlphaISbs.resize(d_mult_number); this->m_AlphaJSbs.resize(d_mult_number); for(k=1;k<=d_mult_number;k++) { this->m_AISbs[k-1]=a_I_mult[k]; this->m_AJSbs[k-1]=a_J_mult[k]; this->m_SigmaSbs[k-1]=sigma_mult[k]; this->m_CSbs[k-1]=C_mult[k]; this->m_KSbs[k-1]=K_mult[k]; this->m_LambdaSbs[k-1]=lambda_mult[k]; this->m_AlphaISbs[k-1]=alpha_I_mult[k]; this->m_AlphaJSbs[k-1]=alpha_J_mult[k]; }; label1:; symmetric_parameters_for_symmetric_scheme(); } catch (...) { memory_release_for_calculate_main_parameters2m( nalp_for_lambda_simulation, d_mult_realizations, d_mult_K_realizations, lambda_mult, lambda_mult_error, C_mult, C_mult_error, a_I_mult, a_I_mult_error, a_J_mult, a_J_mult_error, sigma_mult, sigma_mult_error, alpha_I_mult, alpha_I_mult_error, alpha_J_mult, alpha_J_mult_error, K_C_mult, K_C_mult_error, K_mult, K_mult_error, Sc_mult, Sc_mult_error, alp_distr, alp_distr_errors, alp_mult_distr, alp_mult_distr_errors); throw; }; memory_release_for_calculate_main_parameters2m( nalp_for_lambda_simulation, d_mult_realizations, d_mult_K_realizations, lambda_mult, lambda_mult_error, C_mult, C_mult_error, a_I_mult, a_I_mult_error, a_J_mult, a_J_mult_error, sigma_mult, sigma_mult_error, alpha_I_mult, alpha_I_mult_error, alpha_J_mult, alpha_J_mult_error, K_C_mult, K_C_mult_error, K_mult, K_mult_error, Sc_mult, Sc_mult_error, alp_distr, alp_distr_errors, alp_mult_distr, alp_mult_distr_errors); } void alp_sim::error_in_calculate_main_parameters2m( double C, double &C_error, double C_mult2, double C_mult2_error) { if(C!=0&&C_mult2!=0) { C_error=fabs(C*C_mult2_error/C_mult2); } else { C_error=C_mult2_error; }; } alp_sim::~alp_sim()//destructor { long int i; if(d_alp_obj) { for(i=0;id_elem[i];d_alp_obj->d_elem[i]=NULL; }; if(d_alp_data) { d_alp_data->d_memory_size_in_MB-=sizeof(alp)*d_n_alp_obj/mb_bytes; }; delete d_alp_obj;d_alp_obj=NULL; }; if(d_alp_data) { d_alp_data->d_memory_size_in_MB-=(double)(sizeof(array_positive))/mb_bytes; }; } void alp_sim::kill( bool check_time_, long int ind1_, long int ind2_, long int M_min_, double lambda_, double eps_K_, double &K_C_, double &K_C_error_, long int &level_, long int &diff_opt_) { bool flag=false; long int current_level=(long int)floor(M_min_*0.5); long int recommended_level; //long int number_of_unsucesful_objects=0; long int i; for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; if(i-ind1_+1>alp_obj_tmp->d_alp_data->d_minimum_realizations_number) { alp_obj_tmp->d_check_time_flag=check_time_; alp_obj_tmp->d_time_error_flag=check_time_; }; }; do{ long int i; for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; bool flag=false; while(!flag) { alp_obj_tmp->d_sentinels_flag=false; alp_obj_tmp->kill_upto_level(M_min_,current_level); if(!alp_obj_tmp->d_success) { //number_of_unsucesful_objects++; //if(number_of_unsucesful_objects>/*5+*/0.5*(ind2_-ind1_+1)* // d_alp_obj->d_alp_data->d_eps_K // ) //{ //throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); //}; delete alp_obj_tmp;alp_obj_tmp=NULL; alp_obj_tmp=new alp(d_alp_data); alp_data::assert_mem(alp_obj_tmp); if(i-ind1_+1>alp_obj_tmp->d_alp_data->d_minimum_realizations_number) { alp_obj_tmp->d_check_time_flag=check_time_; alp_obj_tmp->d_time_error_flag=check_time_; }; bool flag=false; while(!flag) { alp_obj_tmp->simulate_alp_upto_the_given_level(M_min_); //if(!alp_obj_tmp->d_success) //{ // number_of_unsucesful_objects++; // if(number_of_unsucesful_objects>/*5+*/0.5*(ind2_-ind1_+1)* // d_alp_obj->d_alp_data->d_eps_K // ) // { //throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); // }; //}; flag=alp_obj_tmp->d_success; }; }; flag=alp_obj_tmp->d_success; }; }; flag=check_K_criterion_during_killing( ind1_, ind2_, lambda_, eps_K_, current_level, recommended_level, diff_opt_, K_C_, K_C_error_); current_level=recommended_level; } while(!flag); level_=current_level; } void alp_sim::get_single_realization( bool check_time_, long int M_min_, long int nalp_, bool killing_flag_, long int level_, long int diff_opt_, alp *&obj_, bool &sucess_flag_, double &d_eps_) { if(!obj_) { obj_=new alp(d_alp_data); alp_data::assert_mem(obj_); d_alp_data->d_memory_size_in_MB+=sizeof(alp)/mb_bytes; }; obj_->d_single_realiztion_calculation_flag=true; obj_->d_check_time_flag=check_time_; d_eps_=d_alp_data->Tmin(d_alp_data->d_eps_K,d_alp_data->d_eps_lambda); alp*&obj=obj_; obj->d_diff_opt=diff_opt_; obj->d_sentinels_flag=d_alp_data->d_sentinels_flag; sucess_flag_=true; while(obj->d_nalpsimulate_next_alp(); if(!obj->d_success) { sucess_flag_=false; delete obj_;obj_=NULL; d_eps_=d_alp_data->d_eps_lambda; d_alp_data->d_memory_size_in_MB-=sizeof(alp)/mb_bytes; return; }; }; if(killing_flag_) { obj->kill_upto_level(M_min_,level_); if(!obj->d_success) { sucess_flag_=false; delete obj_;obj_=NULL; d_eps_=d_alp_data->d_eps_K; d_alp_data->d_memory_size_in_MB-=sizeof(alp)/mb_bytes; return; }; }; } void alp_sim::quick_test( long int trials_number_, double max_time_) { if(trials_number_<=0) { throw error("Unexpected error in alp_sim::quick_test\n",1); }; bool check_time_flag=false; if(max_time_>0) { check_time_flag=true; }; long int alp_number=5; double p_thres=1e-10; double lambda_ungapped=this->d_alp_data->d_is->d_ungap_lambda; if(lambda_ungapped<=0) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; long int score_diff=(long int)alp_data::round(-log(p_thres)/lambda_ungapped); long int i; long int max_number_of_unsuccessful_objects2=(long int)floor(/*5+*/0.5*trials_number_*(d_alp_obj->d_alp_data->d_eps_K+d_alp_obj->d_alp_data->d_eps_lambda)); long int number_of_unsuccessful_objects2=0; double max_time_store=d_alp_data->d_max_time; if(check_time_flag) { d_alp_data->d_max_time=max_time_; }; for(i=0;id_memory_size_in_MB+=(double)(sizeof(alp))/mb_bytes; alp_obj_tmp->d_check_time_flag=check_time_flag; alp_obj_tmp->d_time_error_flag=check_time_flag; alp_obj_tmp->simulate_alp_upto_the_given_number(alp_number+1); success3=alp_obj_tmp->d_success; if(!success3) { delete alp_obj_tmp;alp_obj_tmp=NULL; d_alp_data->d_memory_size_in_MB-=(double)(sizeof(alp))/mb_bytes; number_of_unsuccessful_objects2++; if(number_of_unsuccessful_objects2>max_number_of_unsuccessful_objects2) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; }; }; long int last_alp=alp_obj_tmp->d_alp->d_elem[alp_number]; long int M_upper_level=last_alp+score_diff; alp_obj_tmp->d_sentinels_flag=false; alp_obj_tmp->kill_upto_level(last_alp,last_alp-score_diff,&M_upper_level); if(!alp_obj_tmp->d_success) { number_of_unsuccessful_objects2++; if(number_of_unsuccessful_objects2>max_number_of_unsuccessful_objects2) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; }; delete alp_obj_tmp;alp_obj_tmp=NULL; d_alp_data->d_memory_size_in_MB-=(double)(sizeof(alp))/mb_bytes; }; if(check_time_flag) { d_alp_data->d_max_time=max_time_store; }; } void alp_sim::get_minimal_simulation( long int ind1_, long int ind2_, long int &M_min_, long int &nalp_, long int &nalp_lambda_, bool C_calculation_, bool check_time_flag_) { long int &alp_number=nalp_; void **alp_distr=NULL; void **alp_distr_errors=NULL; try { long int add_alp_number=3; long int add_alp_number_count=0; long int max_alp_number=30; if(d_n_alp_objind2_) { throw error("Unexpected error\n",4); }; alp_number=0; //long int nalp_lambda_equilibration=-1; //create the objects long int i; for(i=d_n_alp_obj;i<=ind2_;i++) { d_alp_obj->set_elem(i,NULL); alp *&alp_obj_tmp=d_alp_obj->d_elem[i]; alp_obj_tmp=new alp(d_alp_data); alp_data::assert_mem(alp_obj_tmp); d_alp_data->d_memory_size_in_MB+=sizeof(alp)/mb_bytes; alp_obj_tmp->d_check_time_flag=check_time_flag_; alp_obj_tmp->d_time_error_flag=check_time_flag_; }; d_n_alp_obj=ind2_+1; bool M_min_flag=false; bool nalp_flag=false; bool criterion_flag=false; long int number_of_fails=0; long int number_of_fails_threshold=5; do{ if(alp_number>=max_alp_number) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",1); }; //long int number_of_unsuccessful_objects=0; long int i; for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; alp_obj_tmp->d_check_time_flag=check_time_flag_; alp_obj_tmp->d_time_error_flag=check_time_flag_; if(alp_obj_tmp->d_nalpsimulate_alp_upto_the_given_number(alp_number+1); //cout<d_success<d_success) { //number_of_unsuccessful_objects++; delete alp_obj_tmp; alp_obj_tmp=NULL; //if(number_of_unsuccessful_objects>/*5+*/0.5*(ind2_-ind1_+1)* // d_alp_obj->d_alp_data->d_eps_lambda*(alp_number+1) // ) //{ //throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); //}; bool success2=false; while(!success2) { alp_obj_tmp=new alp(d_alp_data); alp_data::assert_mem(alp_obj_tmp); long int j; for(j=0;j<=alp_number;j++) { alp_obj_tmp->simulate_alp_upto_the_given_number(j+1); }; success2=alp_obj_tmp->d_success; if(!success2) { delete alp_obj_tmp; alp_obj_tmp=NULL; //number_of_unsuccessful_objects++; //if(number_of_unsuccessful_objects>/*5+*/0.5*(ind2_-ind1_+1)* // d_alp_obj->d_alp_data->d_eps_lambda*(alp_number+1) // ) //{ //throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); //}; }; }; }; }; }; alp_number++; bool inside_simulation_flag=false; double lambda; criterion_flag=the_criterion( alp_number, nalp_lambda_, 0, ind2_, alp_distr, alp_distr_errors, M_min_, M_min_flag, nalp_flag, inside_simulation_flag, C_calculation_, &lambda); if(inside_simulation_flag) { if(lambda<=0) { criterion_flag=false; inside_simulation_flag=false; }; } else { criterion_flag=false; }; //if(nalp_lambda_equilibration==-1&&nalp_flag) //if(nalp_flag) //{ // nalp_lambda_equilibration=alp_number; //}; if(!inside_simulation_flag) { number_of_fails++; long int i; if(alp_distr) { for(i=1;i<=alp_number;i++) { delete (array_positive*)alp_distr[i];alp_distr[i]=NULL; }; delete[]alp_distr;alp_distr=NULL; }; if(alp_distr_errors) { for(i=1;i<=alp_number;i++) { delete (array_positive*)alp_distr_errors[i];alp_distr_errors[i]=NULL; }; delete[]alp_distr_errors;alp_distr_errors=NULL; }; M_min_flag=false; nalp_flag=false; alp_distr=NULL; alp_distr_errors=NULL; alp_number=0; criterion_flag=false; for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; delete alp_obj_tmp;alp_obj_tmp=NULL; }; if(number_of_fails>number_of_fails_threshold) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; for(i=ind1_;i<=ind2_;i++) { alp *alp_obj_tmp; alp_obj_tmp=new alp(d_alp_data); alp_data::assert_mem(alp_obj_tmp); d_alp_obj->set_elem(i,alp_obj_tmp); alp_obj_tmp->d_check_time_flag=check_time_flag_; alp_obj_tmp->d_time_error_flag=check_time_flag_; }; continue; }; if(criterion_flag) { add_alp_number_count++; if(add_alp_number_countd_eps_K, M_min_); }; } else { add_alp_number_count=0; }; } while(!criterion_flag); //nalp_lambda_=alp_data::Tmax(nalp_lambda_equilibration,nalp_lambda_); //nalp_lambda_=alp_data::Tmin(nalp_lambda_,nalp_); nalp_lambda_=nalp_; } catch (...) { memory_release_for_get_minimal_simulation( nalp_, alp_distr, alp_distr_errors); throw; }; memory_release_for_get_minimal_simulation( nalp_, alp_distr, alp_distr_errors); } void alp_sim::memory_release_for_get_minimal_simulation( long int nalp_, void **&alp_distr, void **&alp_distr_errors) { //memory release if(alp_distr) { long int i; for(i=1;i<=nalp_;i++) { delete (array_positive*)alp_distr[i];alp_distr[i]=NULL; }; delete[]alp_distr;alp_distr=NULL; }; if(alp_distr_errors) { long int i; for(i=1;i<=nalp_;i++) { delete (array_positive*)alp_distr_errors[i];alp_distr_errors[i]=NULL; }; delete[]alp_distr_errors;alp_distr_errors=NULL; }; } bool alp_sim::the_criterion(//criteria of stopping of the simulating ALP //if the function returns true then calculates optimal M_min and ALP number //sets the flags M_min_flag_ and nalp_flag_ checking the corresponding condition long int upto_nalp_, long int &nalp_for_lambda_simulation_, long int ind1_, long int ind2_, void **&alp_distr, void **&alp_distr_errors, long int &M_min_, bool &M_min_flag_, bool &nalp_flag_, bool &inside_simulation_flag_, bool C_calculation_, double *lambda_, double *lambda_error_) { nalp_flag_=false; M_min_flag_=false; if(ind1_>ind2_) { throw error("Unexpected error\n",4); }; double lambda=0; double lambda_error=0; double test_difference=0; double test_difference_error=0; long int nalp=upto_nalp_; if(nalp<1) { throw error("Unexpected error\n",4); }; get_and_allocate_alp_distribution( ind1_, ind2_, alp_distr, alp_distr_errors, nalp); calculate_lambda( true, upto_nalp_, nalp_for_lambda_simulation_, inside_simulation_flag_, alp_distr, alp_distr_errors, lambda, lambda_error, test_difference, test_difference_error); if(!inside_simulation_flag_) { return false; }; d_lambda_tmp->set_elem(upto_nalp_,lambda); d_lambda_tmp_errors->set_elem(upto_nalp_,lambda_error); if(C_calculation_) { double C; double C_error; double Sc; double Sc_error; calculate_C( 0, upto_nalp_, alp_distr, alp_distr_errors, lambda, lambda_error, C, C_error, Sc, Sc_error); d_C_tmp->set_elem(upto_nalp_,C); d_C_tmp_errors->set_elem(upto_nalp_,C_error); }; //!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! if(lambda_) { *lambda_=lambda; }; if(lambda_error_) { *lambda_error_=lambda_error; }; if(nalp>=1) { if(test_difference<=test_difference_error) { nalp_flag_=true; /* M_min_flag_=check_K_criterion( nalp, ind1_, ind2_, lambda, d_alp_data->d_eps_K, M_min_); */ M_min_=0; //return M_min_flag_; return true; }; }; return false; } double alp_sim::lambda_exp( long int &i_, double *&exp_array_) { if(exp_array_[i_]==-1) { throw error("The program is not able to calculate the parameters; rescaling penalties and scoring matrix might help\n",3); }; return exp_array_[i_]; } void alp_sim::memory_release_for_calculate_FSC( double *&exp_array, double *&delta_E, double *&delta_E_error, double *&delta_E_E, double *&delta_E_E_error, double *&delta_I, double *&delta_I_error, double *&delta_J, double *&delta_J_error, double *&delta_I_I, double *&delta_I_I_error, double *&delta_I_J, double *&delta_I_J_error, double *&delta_J_J, double *&delta_J_J_error, double *&cov_J_J, double *&cov_J_J_error, double *&cov_I_J, double *&cov_I_J_error, double *&cov_I_I, double *&cov_I_I_error, double *&cov_E_E, double *&cov_E_E_error) { //memory release delete[]exp_array;exp_array=NULL; delete[]delta_E;delta_E=NULL; delete[]delta_E_error;delta_E_error=NULL; delete[]delta_E_E;delta_E_E=NULL; delete[]delta_E_E_error;delta_E_E_error=NULL; delete[]delta_I;delta_I=NULL; delete[]delta_I_error;delta_I_error=NULL; delete[]delta_J;delta_J=NULL; delete[]delta_J_error;delta_J_error=NULL; delete[]delta_I_J;delta_I_J=NULL; delete[]delta_I_J_error;delta_I_J_error=NULL; delete[]delta_J_J;delta_J_J=NULL; delete[]delta_J_J_error;delta_J_J_error=NULL; delete[]delta_I_I;delta_I_I=NULL; delete[]delta_I_I_error;delta_I_I_error=NULL; delete[]cov_I_J;cov_I_J=NULL; delete[]cov_I_J_error;cov_I_J_error=NULL; delete[]cov_J_J;cov_J_J=NULL; delete[]cov_J_J_error;cov_J_J_error=NULL; delete[]cov_I_I;cov_I_I=NULL; delete[]cov_I_I_error;cov_I_I_error=NULL; delete[]cov_E_E;cov_E_E=NULL; delete[]cov_E_E_error;cov_E_E_error=NULL; } void alp_sim::calculate_FSC( long int nalp_, long int ind1_, long int ind2_, void **alp_distr, double lambda_, double Sc_, //double Sc_error_, double &a_I_, double &a_I_error_, double &a_J_, double &a_J_error_, double &sigma_, double &sigma_error_, double &alpha_I_, double &alpha_I_error_, double &alpha_J_, double &alpha_J_error_) { double *exp_array=NULL; double *delta_E=NULL; double *delta_E_error=NULL; double *delta_E_E=NULL; double *delta_E_E_error=NULL; double *delta_I=NULL; double *delta_I_error=NULL; double *delta_J=NULL; double *delta_J_error=NULL; double *delta_I_I=NULL; double *delta_I_I_error=NULL; double *delta_I_J=NULL; double *delta_I_J_error=NULL; double *delta_J_J=NULL; double *delta_J_J_error=NULL; double *cov_J_J=NULL; double *cov_J_J_error=NULL; double *cov_I_J=NULL; double *cov_I_J_error=NULL; double *cov_I_I=NULL; double *cov_I_I_error=NULL; double *cov_E_E=NULL; double *cov_E_E_error=NULL; try { if(nalp_<1) { throw error("Unexpected error\n",4); }; array_positive* tmp=((array_positive*)alp_distr[nalp_]); long int dim=tmp->d_dim; exp_array=new double[dim+1]; alp_data::assert_mem(exp_array); long int i; for(i=0;i<=dim;i++) { double tmp=(double)i*lambda_; if(tmp0) { C_S_constant=Sc_; }; }; double one_div_C_S_constant=1.0/C_S_constant; for(i=ind1_;i<=ind2_;i++) { alp* alp_obj_tmp=d_alp_obj->d_elem[i]; long int j; for(j=1;j<=nalp_;j++) { long int j_1=j-1; long int &E_j_1=alp_obj_tmp->d_alp->d_elem[j_1]; long int &E_j=alp_obj_tmp->d_alp->d_elem[j]; double &weight_j=alp_obj_tmp->d_alp_weights->d_elem[j]; long int &I_j_1=alp_obj_tmp->d_H_I->d_elem[j_1]; long int &I_j=alp_obj_tmp->d_H_I->d_elem[j]; long int &J_j_1=alp_obj_tmp->d_H_J->d_elem[j_1]; long int &J_j=alp_obj_tmp->d_H_J->d_elem[j]; double exp_tmp=lambda_exp(E_j,exp_array)*one_div_C_S_constant; double delta_I_tmp=(I_j-I_j_1)*exp_tmp*weight_j; double delta_J_tmp=(J_j-J_j_1)*exp_tmp*weight_j; double delta_E_tmp=(E_j-E_j_1)*exp_tmp*weight_j; double delta_E_E_tmp=(E_j-E_j_1)*(E_j-E_j_1)*exp_tmp*weight_j; double delta_I_I_tmp=delta_I_tmp*(I_j-I_j_1); double delta_J_J_tmp=delta_J_tmp*(J_j-J_j_1); double delta_I_J_tmp=delta_I_tmp*(J_j-J_j_1); delta_E[j_1]+=delta_E_tmp; delta_E_error[j_1]+=delta_E_tmp*delta_E_tmp; delta_E_E[j_1]+=delta_E_E_tmp; delta_E_E_error[j_1]+=delta_E_E_tmp*delta_E_E_tmp; delta_I[j_1]+=delta_I_tmp; delta_I_error[j_1]+=delta_I_tmp*delta_I_tmp; delta_J[j_1]+=delta_J_tmp; delta_J_error[j_1]+=delta_J_tmp*delta_J_tmp; delta_I_I[j_1]+=delta_I_I_tmp; delta_I_I_error[j_1]+=delta_I_I_tmp*delta_I_I_tmp; delta_I_J[j_1]+=delta_I_J_tmp; delta_I_J_error[j_1]+=delta_I_J_tmp*delta_I_J_tmp; delta_J_J[j_1]+=delta_J_J_tmp; delta_J_J_error[j_1]+=delta_J_J_tmp*delta_J_J_tmp; }; }; double ind_diff=(double)(ind2_-ind1_+1); for(j=0;j* tmp=((array_positive*)alp_distr[j]); array_positive* tmp_errors=((array_positive*)alp_distr_errors[j]); P[j]=0; P_errors[j]=0; long int i; for(i=0;i<=tmp->d_dim;i++) { P[j]+=tmp->d_elem[i]; P_errors[j]+=tmp_errors->d_elem[i]; }; P_errors[j]=alp_reg::sqrt_for_errors(P_errors[j]); }; values_P_ratio=new double[total_number_of_ALP]; alp_data::assert_mem(values_P_ratio); errors_P_ratio=new double[total_number_of_ALP]; alp_data::assert_mem(errors_P_ratio); for(j=0;j* tmp=((array_positive*)alp_distr[j]); array_positive* tmp_errors=((array_positive*)alp_distr_errors[j]); E[j]=0; E_T_beta[j]=0; E_errors[j]=0; E_T_beta_errors[j]=0; long int i; for(i=0;i<=tmp->d_dim;i++) { double tmp_double=exp(lambda_*(double)i); E[j]+=tmp_double*tmp->d_elem[i]; E_errors[j]+=tmp_double*tmp_double*tmp_errors->d_elem[i]; tmp_double=(double)i*exp(lambda_*(double)i); E_T_beta[j]+=tmp_double*tmp->d_elem[i]; E_T_beta_errors[j]+=tmp_double*tmp_double*tmp_errors->d_elem[i]; }; E_errors[j]=alp_reg::sqrt_for_errors(E_errors[j]); E_T_beta_errors[j]=alp_reg::sqrt_for_errors(E_T_beta_errors[j]); }; double E_aver; double E_aver_error; double E_T_beta_diff_aver; double E_T_beta_diff_aver_error; if(total_number_of_ALP==1) { E_aver=E[1]; E_aver_error=E_errors[1]; E_T_beta_diff_aver=E_T_beta[1]-E_T_beta[0]; E_T_beta_diff_aver_error=E_T_beta_errors[1]; } else { long int number_of_elements=total_number_of_ALP; bool cut_left_tail=true; bool cut_right_tail=false; double beta0; double beta1=0; double beta0_error; double beta1_error=0; bool res_was_calculated; alp_reg::robust_regression_sum_with_cut_LSM_beta1_is_defined( 0, number_of_elements-starting_point, E+1+starting_point, E_errors+1+starting_point, cut_left_tail, cut_right_tail, y, E_aver, beta1, E_aver_error, beta1_error, k1_opt, k2_opt, res_was_calculated); if(!res_was_calculated) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; number_of_elements=total_number_of_ALP; alp_reg::robust_regression_sum_with_cut_LSM( 0, number_of_elements-starting_point, E_T_beta+1+starting_point, E_T_beta_errors+1+starting_point, cut_left_tail, cut_right_tail, y, beta0, beta1, beta0_error, beta1_error, k1_opt, k2_opt, res_was_calculated); if(!res_was_calculated) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; E_T_beta_diff_aver=beta1; E_T_beta_diff_aver_error=beta1_error; }; double exp_lambda_error=exp(-lambda_)*lambda_error_; double exp_lambda=(1-exp(-lambda_)); double den_error=alp_data::error_of_the_product(E_T_beta_diff_aver,E_T_beta_diff_aver_error,exp_lambda,exp_lambda_error); double den=(1-exp(-lambda_))*E_T_beta_diff_aver; double nom; double nom_error; if(calculate_C_S_constant_flag) { Sc_error_=E_aver_error; Sc_=E_aver; nom_error=alp_data::error_of_the_product(P_beta_inf,P_beta_inf_error,E_aver,E_aver_error); nom=P_beta_inf*E_aver; } else { double E_aver_sqr_error=alp_data::error_of_the_product(E_aver,E_aver_error,E_aver,E_aver_error); double E_aver_sqr=E_aver*E_aver; nom_error=alp_data::error_of_the_product(P_beta_inf,P_beta_inf_error,E_aver_sqr,E_aver_sqr_error); nom=P_beta_inf*E_aver_sqr; }; C_error_=alp_data::error_of_the_ratio(nom,nom_error,den,den_error); C_=nom/den; } catch (...) { //memory release delete[]values_P_ratio;values_P_ratio=NULL; delete[]errors_P_ratio;errors_P_ratio=NULL; delete[]P;P=NULL; delete[]P_errors;P_errors=NULL; delete[]E;E=NULL; delete[]E_T_beta;E_T_beta=NULL; delete[]E_errors;E_errors=NULL; delete[]E_T_beta_errors;E_T_beta_errors=NULL; throw; }; //memory release delete[]values_P_ratio;values_P_ratio=NULL; delete[]errors_P_ratio;errors_P_ratio=NULL; delete[]P;P=NULL; delete[]P_errors;P_errors=NULL; delete[]E;E=NULL; delete[]E_T_beta;E_T_beta=NULL; delete[]E_errors;E_errors=NULL; delete[]E_T_beta_errors;E_T_beta_errors=NULL; } void alp_sim::get_and_allocate_alp_distribution( long int ind1_, long int ind2_, void **&alp_distr, void **&alp_distr_errors, long int nalp) { if(nalp<=0) { if(nalp<0) { throw error("Unexpected error\n",4); }; alp_distr=NULL; alp_distr_errors=NULL; return; }; void **alp_distr_tmp=NULL; void **alp_distr_errors_tmp=NULL; long int allocation_dim=nalp; long int allocation_dim_tmp=nalp+1; try { long int i; alp_distr_tmp=new void*[nalp+1]; alp_data::assert_mem(alp_distr_tmp); alp_distr_errors_tmp=new void*[nalp+1]; alp_data::assert_mem(alp_distr_errors_tmp); for(i=0;i<=nalp;i++) { alp_distr_tmp[i]=NULL; alp_distr_errors_tmp[i]=NULL; }; for(i=1;i<=nalp-1;i++) { alp_distr_tmp[i]=alp_distr[i]; alp_distr_errors_tmp[i]=alp_distr_errors[i]; }; delete[]alp_distr;alp_distr=NULL; delete[]alp_distr_errors;alp_distr_errors=NULL; alp_distr=alp_distr_tmp;alp_distr_tmp=NULL; alp_distr_errors=alp_distr_errors_tmp;alp_distr_errors_tmp=NULL; allocation_dim=nalp+1; alp_distr[nalp]=new array_positive(d_alp_data); alp_data::assert_mem(alp_distr[nalp]); alp_distr_errors[nalp]=new array_positive(d_alp_data); alp_data::assert_mem(alp_distr_errors[nalp]); for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; long int k=nalp; long int &alp_tmp=alp_obj_tmp->d_alp->d_elem[k]; double &weight_tmp=alp_obj_tmp->d_alp_weights->d_elem[k]; ((array_positive*)alp_distr[k])->increase_elem_by_x(alp_tmp,weight_tmp); ((array_positive*)alp_distr_errors[k])->increase_elem_by_x(alp_tmp,weight_tmp*weight_tmp); }; double ind_diff=(double)(ind2_-ind1_+1); long int k=nalp; array_positive* tmp=((array_positive*)alp_distr[k]); array_positive* tmp_errors=((array_positive*)alp_distr_errors[k]); long int j; for(j=0;j<=tmp->d_dim;j++) { tmp->d_elem[j]/=ind_diff; tmp_errors->d_elem[j]/=ind_diff; tmp_errors->d_elem[j]-=tmp->d_elem[j]*tmp->d_elem[j]; tmp_errors->d_elem[j]/=ind_diff; }; } catch (...) { long int i; if(alp_distr_tmp) { for(i=0;i<=allocation_dim_tmp;i++) { delete (array_positive*)alp_distr_tmp[i];alp_distr_tmp[i]=NULL; }; delete []alp_distr_tmp;alp_distr_tmp=NULL; }; if(alp_distr_errors_tmp) { for(i=0;i<=allocation_dim_tmp;i++) { delete (array_positive*)alp_distr_errors_tmp[i];alp_distr_errors_tmp[i]=NULL; }; delete []alp_distr_errors_tmp;alp_distr_errors_tmp=NULL; }; if(alp_distr) { for(i=0;i<=allocation_dim;i++) { delete (array_positive*)alp_distr[i];alp_distr[i]=NULL; }; delete []alp_distr;alp_distr=NULL; }; if(alp_distr_errors) { for(i=0;i<=allocation_dim;i++) { delete (array_positive*)alp_distr_errors[i];alp_distr_errors[i]=NULL; }; delete []alp_distr_errors;alp_distr_errors=NULL; }; throw; }; } bool alp_sim::check_K_criterion( long int nalp_, long int ind1_, long int ind2_, double lambda_, double eps_K_, long int &M_min_) { if(nalp_<=0) { throw error("Unexpected error\n",4); }; array_positive* diff=NULL; try { diff=new array_positive(d_alp_data); alp_data::assert_mem(diff); double sum_of_weights=0; double M_aver=0; long int i; for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; long int &alp_tmp=alp_obj_tmp->d_alp->d_elem[nalp_]; double &weight_tmp=alp_obj_tmp->d_alp_weights->d_elem[nalp_]; sum_of_weights+=weight_tmp; M_aver+=alp_tmp*weight_tmp; array *cells_counts=alp_obj_tmp->d_cells_counts; long int k; for(k=cells_counts->d_ind0;k<=alp_data::Tmin(alp_tmp,cells_counts->d_dim_plus_d_ind0);k++) { diff->increase_elem_by_x(alp_tmp-k,cells_counts->d_elem[k-cells_counts->d_ind0]*weight_tmp); }; }; double den=0; for(i=0;i<=diff->d_dim;i++) { den+=exp(-lambda_*(double)i)*diff->d_elem[i]; }; if(den<=0||sum_of_weights<=0) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; M_aver/=sum_of_weights; double delta_val=den*eps_K_*(1-exp(-lambda_)); long int diff_opt=1;; for(i=diff->d_dim;i>=0;i--) { if(exp(-lambda_*(double)i)*diff->d_elem[i]>delta_val) { diff_opt=i+1; break; }; }; M_min_=(long int)alp_data::round(M_aver); delete diff;diff=NULL; if(M_averind2_) { throw error("Unexpected error\n",4); }; array_positive* diff=NULL; array_positive* diff_error=NULL; try { diff=new array_positive(d_alp_data); alp_data::assert_mem(diff); diff_error=new array_positive(d_alp_data); alp_data::assert_mem(diff_error); double sum_of_weights=0; double sum_of_weights_error=0; double M_aver=0; long int i; for(i=ind1_;i<=ind2_;i++) { alp* &alp_obj_tmp=d_alp_obj->d_elem[i]; long int &alp_tmp=alp_obj_tmp->d_M; double &weight_tmp=alp_obj_tmp->d_alp_weights->d_elem[alp_obj_tmp->d_nalp_killing]; sum_of_weights+=weight_tmp; sum_of_weights_error+=weight_tmp*weight_tmp; M_aver+=alp_tmp*weight_tmp; array *cells_counts=alp_obj_tmp->d_cells_counts; long int k; for(k=cells_counts->d_ind0;k<=alp_data::Tmin(alp_tmp,cells_counts->d_dim_plus_d_ind0);k++) { double tmp=cells_counts->d_elem[k-cells_counts->d_ind0]*weight_tmp; diff->increase_elem_by_x(alp_tmp-k,tmp); diff_error->increase_elem_by_x(alp_tmp-k,tmp*tmp); }; }; double tmp2=(double)(ind2_-ind1_+1); sum_of_weights/=tmp2; sum_of_weights_error/=tmp2; sum_of_weights_error-=sum_of_weights*sum_of_weights; sum_of_weights_error/=tmp2; sum_of_weights_error=alp_reg::sqrt_for_errors(sum_of_weights_error); for(i=0;i<=diff->d_dim;i++) { diff->d_elem[i]/=tmp2; diff_error->d_elem[i]/=tmp2; diff_error->d_elem[i]-=diff->d_elem[i]*diff->d_elem[i]; diff_error->d_elem[i]/=tmp2; }; double den=0; double den_error=0; for(i=0;i<=diff->d_dim;i++) { double tmp=exp(-lambda_*(double)i); den+=tmp*diff->d_elem[i]; den_error+=tmp*tmp*diff_error->d_elem[i]; }; den_error=alp_reg::sqrt_for_errors(den_error); if(den<=0||sum_of_weights<=0) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; K_C_=sum_of_weights/den; K_C_error_=alp_data::error_of_the_ratio(sum_of_weights,sum_of_weights_error,den,den_error); M_aver/=tmp2; M_aver/=sum_of_weights; double delta_val=den*eps_K_*(1-exp(-lambda_)); long int diff_opt=1;; for(i=diff->d_dim;i>=0;i--) { if(exp(-lambda_*(double)i)*diff->d_elem[i]>delta_val) { diff_opt=i+1; break; }; }; delete diff;diff=NULL; delete diff_error;diff_error=NULL; if(M_aver-diff_optd_is->d_lambda*3; double b=d_alp_data->d_is->d_lambda*2; long int n_partition=30; double eps=1e-10; std::vector res; alp_reg::find_tetta_general( func, func_pointer, a,//[a,b] is the interval for search of equation solution b, n_partition, eps, res); inside_simulation_flag_=true; if(res.size()==0) { inside_simulation_flag_=false; return; }; lambda_=get_root(res,d_alp_data->d_is->d_lambda); tmp_struct.d_calculate_alp_number=true; double f1=func(lambda_,func_pointer);//cout<1) { func(d_lambda_tmp->d_elem[nalp-1],func_pointer); } else { func(d_alp_data->d_is->d_ungap_lambda,func_pointer); }; double sum2=tmp_struct.d_last_sum; double sum2_error=tmp_struct.d_last_sum_error; double max_sum=alp_data::Tmax(fabs(sum1),fabs(sum2)); if(max_sum!=0) { test_difference_=fabs((sum1-sum2)/max_sum); test_difference_error_=0.5*(sum1_error+sum2_error)/max_sum; } else { test_difference_=-1; test_difference_error_=0; }; } double alp_sim::get_root( const std::vector &res_tmp_, double point_) { if(res_tmp_.size()==0) { //throw error("Error in alp_sim::get_root - the equation does not have roots\n",2); throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; long int i; long int p=0; double d1=fabs(point_-res_tmp_[0]); for(i=1;i<(long int)res_tmp_.size();i++) { double d2=fabs(point_-res_tmp_[i]); if(d2d_alp_distr; void **alp_distr_errors=tmp_struct->d_alp_distr_errors; long int nalp=tmp_struct->d_nalp; expect=new double[nalp]; alp_data::assert_mem(expect); expect_errors=new double[nalp]; alp_data::assert_mem(expect_errors); if(nalp<1) { throw error("Unexpected error\n",4); }; long int k; for(k=1;k<=nalp;k++) { array_positive* tmp=((array_positive*)alp_distr[k]); array_positive* tmp_errors=((array_positive*)alp_distr_errors[k]); double val=0; double val_error=0; long int j; for(j=0;j<=tmp->d_dim;j++) { if(tmp->d_elem[j]<=0) { continue; }; double exp_tmp=exp(lambda_*j); val+=exp_tmp*tmp->d_elem[j]; val_error+=exp_tmp*exp_tmp*tmp_errors->d_elem[j]; }; val_error=alp_reg::sqrt_for_errors(val_error); expect[k-1]=val; expect_errors[k-1]=val_error; }; tmp_struct->d_last_sum=expect[nalp-1]; tmp_struct->d_last_sum_error=expect_errors[nalp-1]; if(tmp_struct->d_calculate_alp_number) { double tmp=0.0; long int k; for(k=0;k=0;k--) { if(expect_errors[k]!=0) { tmp1+=1.0/(expect_errors[k]*expect_errors[k]); }; if(tmp1>0.2*tmp) { tmp_alp=k+1; break; }; }; tmp_struct->d_alp_number=tmp_alp; }; if(nalp==1) { double tmp=expect[0]-1.0; tmp_struct->d_f_error=expect_errors[0]; delete[]expect;expect=NULL; delete[]expect_errors;expect_errors=NULL; return tmp; }; long int min_length=0; long int number_of_elements=nalp; bool cut_left_tail=true; bool cut_right_tail=false; double y=2; double beta0; double beta1; double beta0_error; double beta1_error; long int k1_opt; long int k2_opt; bool res_was_calculated; alp_reg::robust_regression_sum_with_cut_LSM( min_length, number_of_elements, expect, expect_errors, cut_left_tail, cut_right_tail, y, beta0, beta1, beta0_error, beta1_error, k1_opt, k2_opt, res_was_calculated); if(!res_was_calculated) { throw error("Error - you have exceeded the calculation time or memory limit.\nThe error might indicate that the regime is linear or too close to linear to permit efficient computation.\nPossible solutions include changing the randomization seed, or increasing the allowed calculation time and the memory limit.\n",3); }; delete[]expect;expect=NULL; delete[]expect_errors;expect_errors=NULL; tmp_struct->d_f_error=beta1_error; return beta1; } catch (...) { delete[]expect;expect=NULL; delete[]expect_errors;expect_errors=NULL; throw; }; }