/* bam_lpileup.c -- lplbuf routines. Copyright (C) 2008, 2009, 2013 Genome Research Ltd. Author: Heng Li Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. */ #include #include #include #include #include "bam_plbuf.h" #include "bam_lpileup.h" #include "samtools.h" #include #define TV_GAP 2 typedef struct __freenode_t { uint32_t level:28, cnt:4; struct __freenode_t *next; } freenode_t, *freenode_p; #define freenode_lt(a,b) ((a)->cnt < (b)->cnt || ((a)->cnt == (b)->cnt && (a)->level < (b)->level)) KSORT_INIT(node, freenode_p, freenode_lt) /* Memory pool, similar to the one in bam_pileup.c */ typedef struct { int cnt, n, max; freenode_t **buf; } mempool_t; static mempool_t *mp_init(void) { return (mempool_t*)calloc(1, sizeof(mempool_t)); } static void mp_destroy(mempool_t *mp) { int k; for (k = 0; k < mp->n; ++k) free(mp->buf[k]); free(mp->buf); free(mp); } static inline freenode_t *mp_alloc(mempool_t *mp) { ++mp->cnt; if (mp->n == 0) return (freenode_t*)calloc(1, sizeof(freenode_t)); else return mp->buf[--mp->n]; } static inline void mp_free(mempool_t *mp, freenode_t *p) { --mp->cnt; p->next = 0; p->cnt = TV_GAP; if (mp->n == mp->max) { mp->max = mp->max? mp->max<<1 : 256; mp->buf = (freenode_t**)realloc(mp->buf, sizeof(freenode_t*) * mp->max); } mp->buf[mp->n++] = p; } /* core part */ struct __bam_lplbuf_t { int max, n_cur, n_pre; int max_level, *cur_level, *pre_level; mempool_t *mp; freenode_t **aux, *head, *tail; int n_nodes, m_aux; bam_pileup_f func; void *user_data; bam_plbuf_t *plbuf; }; void bam_lplbuf_reset(bam_lplbuf_t *buf) { freenode_t *p, *q; bam_plbuf_reset(buf->plbuf); for (p = buf->head; p->next;) { q = p->next; mp_free(buf->mp, p); p = q; } buf->head = buf->tail; buf->max_level = 0; buf->n_cur = buf->n_pre = 0; buf->n_nodes = 0; } static int tview_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pl, void *data) { bam_lplbuf_t *tv = (bam_lplbuf_t*)data; freenode_t *p; int i, l, max_level; // allocate memory if necessary if (tv->max < n) { // enlarge tv->max = n; kroundup32(tv->max); tv->cur_level = (int*)realloc(tv->cur_level, sizeof(int) * tv->max); tv->pre_level = (int*)realloc(tv->pre_level, sizeof(int) * tv->max); } tv->n_cur = n; // update cnt for (p = tv->head; p->next; p = p->next) if (p->cnt > 0) --p->cnt; // calculate cur_level[] max_level = 0; for (i = l = 0; i < n; ++i) { const bam_pileup1_t *p = pl + i; if (p->is_head) { if (tv->head->next && tv->head->cnt == 0) { // then take a free slot freenode_t *p = tv->head->next; tv->cur_level[i] = tv->head->level; mp_free(tv->mp, tv->head); tv->head = p; --tv->n_nodes; } else tv->cur_level[i] = ++tv->max_level; } else { tv->cur_level[i] = tv->pre_level[l++]; if (p->is_tail) { // then return a free slot tv->tail->level = tv->cur_level[i]; tv->tail->next = mp_alloc(tv->mp); tv->tail = tv->tail->next; ++tv->n_nodes; } } if (tv->cur_level[i] > max_level) max_level = tv->cur_level[i]; ((bam_pileup1_t*)p)->level = tv->cur_level[i]; } assert(l == tv->n_pre); tv->func(tid, pos, n, pl, tv->user_data); // sort the linked list if (tv->n_nodes) { freenode_t *q; if (tv->n_nodes + 1 > tv->m_aux) { // enlarge tv->m_aux = tv->n_nodes + 1; kroundup32(tv->m_aux); tv->aux = (freenode_t**)realloc(tv->aux, sizeof(freenode_t*) * tv->m_aux); } for (p = tv->head, i = l = 0; p->next;) { if (p->level > max_level) { // then discard this entry q = p->next; mp_free(tv->mp, p); p = q; } else { tv->aux[i++] = p; p = p->next; } } tv->aux[i] = tv->tail; // add a proper tail for the loop below tv->n_nodes = i; if (tv->n_nodes) { ks_introsort(node, tv->n_nodes, tv->aux); for (i = 0; i < tv->n_nodes; ++i) tv->aux[i]->next = tv->aux[i+1]; tv->head = tv->aux[0]; } else tv->head = tv->tail; } // clean up tv->max_level = max_level; memcpy(tv->pre_level, tv->cur_level, tv->n_cur * 4); // squeeze out terminated levels for (i = l = 0; i < n; ++i) { const bam_pileup1_t *p = pl + i; if (!p->is_tail) tv->pre_level[l++] = tv->pre_level[i]; } tv->n_pre = l; /* fprintf(stderr, "%d\t", pos+1); for (i = 0; i < n; ++i) { const bam_pileup1_t *p = pl + i; if (p->is_head) fprintf(stderr, "^"); if (p->is_tail) fprintf(stderr, "$"); fprintf(stderr, "%d,", p->level); } fprintf(stderr, "\n"); */ return 0; } bam_lplbuf_t *bam_lplbuf_init(bam_pileup_f func, void *data) { bam_lplbuf_t *tv; tv = (bam_lplbuf_t*)calloc(1, sizeof(bam_lplbuf_t)); tv->mp = mp_init(); tv->head = tv->tail = mp_alloc(tv->mp); tv->func = func; tv->user_data = data; tv->plbuf = bam_plbuf_init(tview_func, tv); return (bam_lplbuf_t*)tv; } void bam_lplbuf_destroy(bam_lplbuf_t *tv) { freenode_t *p, *q; free(tv->cur_level); free(tv->pre_level); bam_plbuf_destroy(tv->plbuf); free(tv->aux); for (p = tv->head; p->next;) { q = p->next; mp_free(tv->mp, p); p = q; } mp_free(tv->mp, p); assert(tv->mp->cnt == 0); mp_destroy(tv->mp); free(tv); } int bam_lplbuf_push(const bam1_t *b, bam_lplbuf_t *tv) { return bam_plbuf_push(b, tv->plbuf); }