******************************************************************************** MAST - Motif Alignment and Search Tool ******************************************************************************** MAST version 3.0 (Release date: 2004/08/18 09:07:01) For further information on how to interpret these results or to get a copy of the MAST software please access http://meme.sdsc.edu. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Michael Gribskov, "Combining evidence using p-values: application to sequence homology searches", Bioinformatics, 14(48-54), 1998. ******************************************************************************** ******************************************************************************** DATABASE AND MOTIFS ******************************************************************************** DATABASE adh.s (peptide) Last updated on Mon Aug 16 21:19:59 2004 Database contains 33 sequences, 9996 residues MOTIFS meme.adh.oops.txt (peptide) MOTIF WIDTH BEST POSSIBLE MATCH ----- ----- ------------------- 1 29 YSASKFAVRMLTRSMAHEYAPHGIRVNCI 2 29 KVVLITGCSSGIGKATAKHLHKEGAKVVL PAIRWISE MOTIF CORRELATIONS: MOTIF 1 ----- ----- 2 0.30 No overly similar pairs (correlation > 0.60) found. Random model letter frequencies (from non-redundant database): A 0.073 C 0.018 D 0.052 E 0.062 F 0.040 G 0.069 H 0.022 I 0.056 K 0.058 L 0.092 M 0.023 N 0.046 P 0.051 Q 0.041 R 0.052 S 0.074 T 0.059 V 0.064 W 0.013 Y 0.033 ******************************************************************************** ******************************************************************************** SECTION I: HIGH-SCORING SEQUENCES ******************************************************************************** - Each of the following 33 sequences has E-value less than 10. - The E-value of a sequence is the expected number of sequences in a random database of the same size that would match the motifs as well as the sequence does and is equal to the combined p-value of the sequence times the number of sequences in the database. - The combined p-value of a sequence measures the strength of the match of the sequence to all the motifs and is calculated by o finding the score of the single best match of each motif to the sequence (best matches may overlap), o calculating the sequence p-value of each score, o forming the product of the p-values, o taking the p-value of the product. - The sequence p-value of a score is defined as the probability of a random sequence of the same length containing some match with as good or better a score. - The score for the match of a position in a sequence to a motif is computed by by summing the appropriate entry from each column of the position-dependent scoring matrix that represents the motif. - Sequences shorter than one or more of the motifs are skipped. - The table is sorted by increasing E-value. ******************************************************************************** SEQUENCE NAME DESCRIPTION E-VALUE LENGTH ------------- ----------- -------- ------ BUDC_KLETE ACETOIN(DIACETYL) REDUCTA... 2.6e-33 241 YRTP_BACSU HYPOTHETICAL 25.3 KD PROT... 4.3e-33 238 AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP... 4.5e-33 244 HDE_CANTR HYDRATASE-DEHYDROGENASE-E... 1.6e-32 906 HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DE... 4.9e-31 255 DHII_HUMAN CORTICOSTEROID 11-BETA-DE... 8.2e-31 292 FIXR_BRAJA FIXR PROTEIN 2.6e-30 278 DHGB_BACME GLUCOSE 1-DEHYDROGENASE B... 3.2e-30 262 NODG_RHIME NODULATION PROTEIN G (HOS... 3.4e-29 245 RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (... 6.2e-29 249 YINL_LISMO HYPOTHETICAL 26.8 KD PROT... 6.6e-29 248 DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYD... 1.2e-28 270 HMTR_LEIMA no comment 5.1e-28 287 2BHD_STREX 20-BETA-HYDROXYSTEROID DE... 5.9e-28 255 ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXY... 4.8e-27 248 DHB2_HUMAN no comment 1.7e-26 387 BDH_HUMAN D-BETA-HYDROXYBUTYRATE DE... 2.8e-26 343 BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DE... 4.2e-26 249 FVT1_HUMAN no comment 8.9e-26 332 GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DE... 5.1e-25 259 DHB3_HUMAN no comment 8.3e-25 310 3BHD_COMTE 3-BETA-HYDROXYSTEROID DEH... 1.4e-24 253 LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC... 8.1e-24 305 DHES_HUMAN ESTRADIOL 17 BETA-DEHYDRO... 2.4e-22 327 RFBB_NEIGO no comment 3.2e-19 346 BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDRO... 1e-18 275 YURA_MYXXA no comment 1.9e-18 258 PCR_PEA no comment 7.2e-18 399 DHCA_HUMAN no comment 1.1e-17 276 ADH_DROME ALCOHOL DEHYDROGENASE (EC... 2.7e-14 255 MAS1_AGRRA no comment 3e-14 476 FABI_ECOLI no comment 9.7e-14 262 CSGA_MYXXA no comment 2.5e-12 166 ******************************************************************************** ******************************************************************************** SECTION II: MOTIF DIAGRAMS ******************************************************************************** - The ordering and spacing of all non-overlapping motif occurrences are shown for each high-scoring sequence listed in Section I. - A motif occurrence is defined as a position in the sequence whose match to the motif has POSITION p-value less than 0.0001. - The POSITION p-value of a match is the probability of a single random subsequence of the length of the motif scoring at least as well as the observed match. - For each sequence, all motif occurrences are shown unless there are overlaps. In that case, a motif occurrence is shown only if its p-value is less than the product of the p-values of the other (lower-numbered) motif occurrences that it overlaps. - The table also shows the E-value of each sequence. - Spacers and motif occurences are indicated by o -d- `d' residues separate the end of the preceding motif occurrence and the start of the following motif occurrence o [n] occurrence of motif `n' with p-value less than 0.0001. ******************************************************************************** SEQUENCE NAME E-VALUE MOTIF DIAGRAM ------------- -------- ------------- BUDC_KLETE 2.6e-33 2_[2]_120_[1]_61 YRTP_BACSU 4.3e-33 6_[2]_119_[1]_55 AP27_MOUSE 4.5e-33 7_[2]_112_[1]_67 HDE_CANTR 1.6e-32 8_[2]_125_[1]_131_[2]_115_[1]_411 HDHA_ECOLI 4.9e-31 11_[2]_74_[1]_15_[1]_68 DHII_HUMAN 8.2e-31 34_[2]_119_[1]_81 FIXR_BRAJA 2.6e-30 36_[2]_123_[1]_61 DHGB_BACME 3.2e-30 7_[2]_123_[1]_74 NODG_RHIME 3.4e-29 6_[2]_116_[1]_65 RIDH_KLEAE 6.2e-29 14_[2]_116_[1]_61 YINL_LISMO 6.6e-29 5_[2]_75_[2]_15_[1]_66 DHMA_FLAS1 1.2e-28 14_[2]_121_[1]_77 HMTR_LEIMA 5.1e-28 6_[2]_157_[1]_66 2BHD_STREX 5.9e-28 6_[2]_116_[1]_75 ENTA_ECOLI 4.8e-27 5_[2]_109_[1]_76 DHB2_HUMAN 1.7e-26 82_[2]_120_[1]_127 BDH_HUMAN 2.8e-26 55_[2]_123_[1]_107 BA72_EUBSP 4.2e-26 6_[2]_121_[1]_64 FVT1_HUMAN 8.9e-26 32_[2]_124_[1]_118 GUTD_ECOLI 5.1e-25 2_[2]_122_[1]_77 DHB3_HUMAN 8.3e-25 48_[2]_120_[1]_84 3BHD_COMTE 1.4e-24 6_[2]_115_[1]_74 LIGD_PSEPA 8.1e-24 6_[2]_121_[1]_120 DHES_HUMAN 2.4e-22 2_[2]_50_[2]_44_[1]_144 RFBB_NEIGO 3.2e-19 6_[2]_129_[1]_153 BPHB_PSEPS 1e-18 5_[2]_118_[1]_94 YURA_MYXXA 1.9e-18 65_[2]_22_[2]_14_[1]_70 PCR_PEA 7.2e-18 25_[1]_32_[2]_284 DHCA_HUMAN 1.1e-17 4_[2]_159_[1]_55 ADH_DROME 2.7e-14 6_[2]_116_[1]_75 MAS1_AGRRA 3e-14 245_[2]_74_[1]_14_[1]_56 FABI_ECOLI 9.7e-14 6_[2]_123_[1]_75 CSGA_MYXXA 2.5e-12 51_[2]_7_[1]_50 ******************************************************************************** ******************************************************************************** SECTION III: ANNOTATED SEQUENCES ******************************************************************************** - The positions and p-values of the non-overlapping motif occurrences are shown above the actual sequence for each of the high-scoring sequences from Section I. - A motif occurrence is defined as a position in the sequence whose match to the motif has POSITION p-value less than 0.0001 as defined in Section II. - For each sequence, the first line specifies the name of the sequence. - The second (and possibly more) lines give a description of the sequence. - Following the description line(s) is a line giving the length, combined p-value, and E-value of the sequence as defined in Section I. - The next line reproduces the motif diagram from Section II. - The entire sequence is printed on the following lines. - Motif occurrences are indicated directly above their positions in the sequence on lines showing o the motif number of the occurrence, o the position p-value of the occurrence, o the best possible match to the motif, and o columns whose match to the motif has a positive score (indicated by a plus sign). ******************************************************************************** BUDC_KLETE ACETOIN(DIACETYL) REDUCTASE (EC 1.1.1.5) (ACETOIN DEHYDROGENASE) LENGTH = 241 COMBINED P-VALUE = 7.82e-35 E-VALUE = 2.6e-33 DIAGRAM: 2_[2]_120_[1]_61 [2] 7.9e-21 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++++++++++++++ + + 1 MQKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATATAVAAEINQAGGRAVAIKVDVSRRDQVFAAVEQARK [1] 2.6e-21 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++++++++++ ++++++ 151 VYSSSKFAVRGLTQTAARDLAPLGITVNGFCPGIVKTPMWAEIDRQCRKRRANRWATARLNLPNASPLAACRSLK YRTP_BACSU HYPOTHETICAL 25.3 KD PROTEIN IN RTP 5'REGION (ORF238) LENGTH = 238 COMBINED P-VALUE = 1.31e-34 E-VALUE = 4.3e-33 DIAGRAM: 6_[2]_119_[1]_55 [2] 2.8e-19 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++++++++++++++++ ++ + 1 MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVEKVAEEVKALGVKAAFAAADVKDADQVNQAVA [1] 1.3e-22 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++++++++ ++++++++++++++++++++ 151 VTSAYSASKFAVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVAQLKLDPR AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP27) LENGTH = 244 COMBINED P-VALUE = 1.37e-34 E-VALUE = 4.5e-33 DIAGRAM: 7_[2]_112_[1]_67 [2] 7.4e-20 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++ ++++++++++++++ 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIG [1 4. YS ++ 76 PVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYS ] 8e-22 ASKFAVRMLTRSMAHEYAPHGIRVNCI ++++++++++++++++++++ ++++++ 151 STKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSD HDE_CANTR HYDRATASE-DEHYDROGENASE-EPIMERASE (HDE) LENGTH = 906 COMBINED P-VALUE = 4.94e-34 E-VALUE = 1.6e-32 DIAGRAM: 8_[2]_125_[1]_131_[2]_115_[1]_411 [2] 2.5e-19 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++++++ + +++++ ++++++ 1 MSPVDFKDKVVIITGAGGGLGKYYSLEFAKLGAKVVVNDLGGALNGQGGNSKAADVVVDEIVKNGGVAVADYNNV [1] 2.8e-13 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + +++ ++ ++ ++++++ ++++++ +++ 151 PAGLYGNFGQANYASAKSALLGFAETLAKEGAKYNIKANAIAPLARSRMTESILPPPMLEKLGPEKVAPLVLYLS [2] 1.5e-24 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++ +++++++++++++++++++ 301 TNEARKLPANDASGAPTVSLKDKVVLITGAGAGLGKEYAKWFAKYGAKVVVNDFKDATKTVDEIKAAGGEAWPDQ [1] 5.2e-18 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++++++++ +++++++ + ++ +++++++ 451 NITSTSGIYGNFGQANYSSSKAGILGLSKTMAIEGAKNNIKVNIVAPHAETAMTLTIFREQDKNLYHADQVAPLL HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (HSDH) LENGTH = 255 COMBINED P-VALUE = 1.49e-32 E-VALUE = 4.9e-31 DIAGRAM: 11_[2]_74_[1]_15_[1]_68 [2] 4.3e-21 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++ +++++++++++++++++++ 1 MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQEL [1] 2.9e-05 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + ++ ++++ + ++++ + + 76 SALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAE [1] 8.6e-19 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + +++++ +++++ +++++++++++++++ 151 NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIA DHII_HUMAN CORTICOSTEROID 11-BETA-DEHYDROGENASE (EC 1.1.1.146) (11-DH) (11-BETA- HYDROXYSTEROID DEHYDROGENASE) (11-BETA-HSD) LENGTH = 292 COMBINED P-VALUE = 2.49e-32 E-VALUE = 8.2e-31 DIAGRAM: 34_[2]_119_[1]_81 [2] 3.9e-24 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++++++++++++++++++ 1 MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV [1] 1.2e-15 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++ ++ +++++ +++++++ 151 TVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK FIXR_BRAJA FIXR PROTEIN LENGTH = 278 COMBINED P-VALUE = 7.83e-32 E-VALUE = 2.6e-30 DIAGRAM: 36_[2]_123_[1]_61 [2] 3.2e-18 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++ +++++++++++++ + ++++++ 1 MGLDLPNDNLIRGPLPEAHLDRLVDAVNARVDRGEPKVMLLTGASRGIGHATAKLFSEAGWRIISCARQPFDGER [1] 5.1e-21 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + +++++ ++++++++++++++++++++ 151 APILLAQGLFDELRAASGSIVNVTSIAGSRVHPFAGSAYATSKAALASLTRELAHDYAPHGIRVNAIAPGEIRTD DHGB_BACME GLUCOSE 1-DEHYDROGENASE B (EC 1.1.1.47) LENGTH = 262 COMBINED P-VALUE = 9.77e-32 E-VALUE = 3.2e-30 DIAGRAM: 7_[2]_123_[1]_74 [2] 4.4e-19 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++ + +++++++++++++ +++++ 1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEEIKKVGGEAIAVKGDVTVESDVIN [1] 5.3e-20 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + +++++++ +++++++++++++++++++ 151 KIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEE NODG_RHIME NODULATION PROTEIN G (HOST-SPECIFICITY OF NODULATION PROTEIN C) LENGTH = 245 COMBINED P-VALUE = 1.03e-30 E-VALUE = 3.4e-29 DIAGRAM: 6_[2]_116_[1]_65 [2] 4.0e-16 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++ ++ ++++ ++++++ + + 1 MFELTGRKALVTGASGAIGGAIARVLHAQGAIVGLHGTQIEKLETLATELGDRVKLFPANLANRDEVKALGQRAE [1] 7.3e-22 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++++++++++ +++++++ 151 NYCASKAGMIGFSKSLAQEIATRNITVNCVAPGFIESAMTDKLNHKQKEKIMVAIPIHRMGTGTEVASAVAYLAS RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (EC 1.1.1.56) (RDH) LENGTH = 249 COMBINED P-VALUE = 1.88e-30 E-VALUE = 6.2e-29 DIAGRAM: 14_[2]_116_[1]_61 [2] 7.0e-21 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++ +++++++++++++++++ +++++++ 1 MKHSVSSMNTSLSGKVAAITGAASGIGLECARTLLGAGAKVVLIDREGEKLNKLVAELGENAFALQVDLMQADQV [1] 7.4e-17 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++++++++++++++ +++++++++++ ++ 151 VVPVIWEPVYTASKFAVQAFVHTTRRQVAQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESV YINL_LISMO HYPOTHETICAL 26.8 KD PROTEIN IN INLA 5'REGION (ORFA) LENGTH = 248 COMBINED P-VALUE = 1.99e-30 E-VALUE = 6.6e-29 DIAGRAM: 5_[2]_75_[2]_15_[1]_66 [2] 2.9e-23 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++++++++++ +++++++ ++ 1 MTIKNKVIIITGASSGIGKATALLLAEKGAKLVLAARRVEKLEKIVQIIKANSGEAIFAKTDVTKREDNKKLVEL [2] 3.8e-05 KVVLITGCSSGIGKATAKHLHKEGAKVVL + + + ++ + +++ ++ + 76 AIERYGKVDAIFLNAGIMPNSPLSALKEDEWEQMIDINIKGVLNGIAAVLPSFIAQKSGHIIATSSVAGLKAYPG [1] 1.9e-14 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++ +++ ++++ ++++ ++++ 151 GAVYGATKWAVRDLMEVLRMESAQEGTNIRTATIYPAAINTELLETITDKETEQGMTSLYKQYGITPDRIASIVA DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYDROGENASE (EC 1.1.1.233) (NAM-DH) LENGTH = 270 COMBINED P-VALUE = 3.65e-30 E-VALUE = 1.2e-28 DIAGRAM: 14_[2]_121_[1]_77 [2] 2.0e-19 KVVLITGCSSGIGKATAKHLHKEGAKVVL + +++++++++++++++++ +++++++++ 1 TTAGVSRRPGRLAGKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATRYEEPGAIPIACDLADRAAIDA [1] 4.2e-18 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + ++++++ +++++++++++++++ ++++ 151 GSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGILVNMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRP HMTR_LEIMA no comment LENGTH = 287 COMBINED P-VALUE = 1.55e-29 E-VALUE = 5.1e-28 DIAGRAM: 6_[2]_157_[1]_66 [2] 1.6e-17 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++ +++++++ ++++++ +++ 1 MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVS [1] 2.1e-19 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++++++++++ +++++++ 151 PYFLIKAFAHRSRHPSQASRTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGL 2BHD_STREX 20-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.53) LENGTH = 255 COMBINED P-VALUE = 1.78e-29 E-VALUE = 5.9e-28 DIAGRAM: 6_[2]_116_[1]_75 [2] 7.1e-18 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++ + +++ +++++++++ 1 MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAR [1] 6.8e-19 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++ +++++++ +++++++ 151 SYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLL ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE DEHYDROGENASE (EC 1.3.1.28) LENGTH = 248 COMBINED P-VALUE = 1.45e-28 E-VALUE = 4.8e-27 DIAGRAM: 5_[2]_109_[1]_76 [2] 3.7e-20 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++++++++++++++++ 1 MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDA [1] 1.2e-15 YSASKFA +++++++ 76 LVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAA VRMLTRSMAHEYAPHGIRVNCI ++++ + ++++ ++++++++ 151 LKSLALSVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFL DHB2_HUMAN no comment LENGTH = 387 COMBINED P-VALUE = 5.05e-28 E-VALUE = 1.7e-26 DIAGRAM: 82_[2]_120_[1]_127 [2] 3.4e-17 KVVLITGCSSGIGKATAKHLHKEGAKVVL + ++++++++++++++++++ + ++ +++ 76 ELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYS [1] 1.7e-18 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++ ++++++++++++ ++ 226 MERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI BDH_HUMAN D-BETA-HYDROXYBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.30) (BDH) (3-HYDROXYBUTYRATE DEHYDROGENASE) (FRAGMENT) LENGTH = 343 COMBINED P-VALUE = 8.57e-28 E-VALUE = 2.8e-26 DIAGRAM: 55_[2]_123_[1]_107 [2] 2.3e-18 KVVLITGCSSGIGKATAKHL + +++++++++ ++++++++ 1 GLRPPPPGRFSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHL HKEGAKVVL +++++ +++ 76 HSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVFRSEEVEKVVGDCPFEPEGPEKGMWGLVNNAGISTF [1] 5.5e-17 YSASKFAVRMLTRSMAHE ++ +++++++++++++++ 151 GEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYE YAPHGIRVNCI +++ +++++++ 226 MYPLGVKVSVVEPGNFIAATSLYNPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (BILE ACID 7-DEHYDROXYLASE) (BILE ACID-INDUCIBLE PROTEIN) LENGTH = 249 COMBINED P-VALUE = 1.28e-27 E-VALUE = 4.2e-26 DIAGRAM: 6_[2]_121_[1]_64 [2] 2.6e-18 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++ ++++++ ++ ++ +++++ + 1 MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAA [1] 1.5e-16 YSASKFAVRMLTRSMAHEYAPHGIRVNCI + +++++++++++ + +++ +++++++++ 151 SLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVY FVT1_HUMAN no comment LENGTH = 332 COMBINED P-VALUE = 2.70e-27 E-VALUE = 8.9e-26 DIAGRAM: 32_[2]_124_[1]_118 [2] 2.3e-17 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++++++++++++++++ + + 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE [1] 1.9e-17 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++ ++++++++++++++++ 151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFA GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DEHYDROGENASE (EC 1.1.1.140) (GLUCITOL-6- PHOSPHATE DEHYDROGENASE) (KETOSEPHOSPHATE REDUCTASE) LENGTH = 259 COMBINED P-VALUE = 1.54e-26 E-VALUE = 5.1e-25 DIAGRAM: 2_[2]_122_[1]_77 [2] 1.5e-14 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++ ++++ ++ +++ ++++++++ + 1 MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSCLALSRGV [1] 3.0e-19 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++ +++++++++++++++++++++ 151 NSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGC DHB3_HUMAN no comment LENGTH = 310 COMBINED P-VALUE = 2.53e-26 E-VALUE = 8.3e-25 DIAGRAM: 48_[2]_120_[1]_84 [2] 7.4e-19 KVVLITGCSSGIGKATAKHLHKEGAKV +++++++++ ++++++ ++++++ ++ 1 MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYYKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNV VL ++ 76 VLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEI [1] 6.7e-15 YSASKFAVRMLTRSMAHEYAPHGIRVNC ++++++++++++++++ +++ + + +++ 151 QSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV I + 226 LTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV 3BHD_COMTE 3-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.51) LENGTH = 253 COMBINED P-VALUE = 4.25e-26 E-VALUE = 1.4e-24 DIAGRAM: 6_[2]_115_[1]_74 [2] 2.6e-18 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++ ++++++ ++ +++++ 1 TNRLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVSSEADWTLVMAAVQ [1] 5.1e-15 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++++++ +++++ +++ 151 YSASKAAVSALTRAAALSCRKQGYAIRVNSIHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQL LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC -.-.-.-) LENGTH = 305 COMBINED P-VALUE = 2.45e-25 E-VALUE = 8.1e-24 DIAGRAM: 6_[2]_121_[1]_120 [2] 6.5e-17 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++ +++++++ ++ ++ + ++++++++ 1 MKDFQDQVAFITGGASGAGFGQAKVFGQAGAKIVVADVRAEAVEKAVAELEGLGITAHGIVLDIMDREAYARAAD [1] 7.9e-16 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++ +++++ +++ ++++++ ++++ 151 SALAGPYSAAKAASINLMEGYRQGLEKYGIGVSVCTPANIKSNIAEASRLRPAKYGTSGYVENEESIASLHSIHQ DHES_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) (20 ALPHA-HYDROXYSTEROID DEHYDROGENASE) (E2DH) (17-BETA-HSD) (PLACENTAL 17-BETA-HYDROXYSTEROID DEHYDROGENASE) LENGTH = 327 COMBINED P-VALUE = 7.31e-24 E-VALUE = 2.4e-22 DIAGRAM: 2_[2]_50_[2]_44_[1]_144 [2] 1.4e-14 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++++++ +++++ ++ + 1 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAA [2] 9.3e-05 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++ + ++ ++++ ++ + + + + 76 RERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLP [1] 1.0e-16 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++++++++++ + + +++ + + 151 FNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQV RFBB_NEIGO no comment LENGTH = 346 COMBINED P-VALUE = 9.68e-21 E-VALUE = 3.2e-19 DIAGRAM: 6_[2]_129_[1]_153 [2] 1.8e-13 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++ ++ +++++ +++ ++ 1 MQTEGKKNILVTGGAGFIGSAVVRHIIQNTRDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICDRAELDRVF [1] 1.0e-14 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++ +++++++++ ++ ++ ++ 151 DLFTETTPYAPSSPYSASKAAADHLVRAWQRTYRLPSIVSNCSNNYGPRQFPEKLIPLMILNALSGKPLPVYGDG BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDROGENASE (EC 1.3.1.-) LENGTH = 275 COMBINED P-VALUE = 3.02e-20 E-VALUE = 1e-18 DIAGRAM: 5_[2]_118_[1]_94 [2] 8.6e-15 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++++ +++++ ++ 1 MKLKGEAVLITGGASGLGRALVDRFVAEAKVAVLDKSAERLAELETDLGDNVLGIVGDVRSLEDQKQAASRCVAR [1] 1.2e-12 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++++++++++++++++++++++ + + 151 PLYTAAKQAIVGLVRELAFELAPYVRVNGVGPGGMNSDMRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEE YURA_MYXXA no comment LENGTH = 258 COMBINED P-VALUE = 5.64e-20 E-VALUE = 1.9e-18 DIAGRAM: 65_[2]_22_[2]_14_[1]_70 [2] 5.6e-05 KVVLITGCSS + ++ ++ 1 RQHTGGLHGGDELPDGVGDGCLQRPGTRAGAVARQAGVRVFAAGRRLPQLQAADEAPGGRRHRGARGVDVTKADA [2] 5.7e-08 GIGKATAKHLHKEGAKVVL KVVLITGCSSGIGKATAKHLHKEGAKVVL + + +++ + + ++ + +++++ + + ++ ++ + + 76 TLERIRALDAEAGGLDLVVANAGVGGTTNAKRLPWERVRGIIDTNVTGAAATLSAVLPQMVERKRGHLVGVSSLA [1] 3.8e-19 YSASKFAVRMLTRSMAHEYAPHGIRVNCI +++++++++ ++++++++++ ++++++++ 151 GFRGLPATRYSASKAFLSTFMESLRVDLRGTGVRVTCIYPGFVKSELTATNNFPMPFLMETHDAVELMGKGIVRG PCR_PEA no comment LENGTH = 399 COMBINED P-VALUE = 2.17e-19 E-VALUE = 7.2e-18 DIAGRAM: 25_[1]_32_[2]_284 [1] 1.7e-08 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++ ++++++++++ + + +++ + 1 MALQTASMLPASFSIPKEGKIGASLKDSTLFGVSSLSDSLKGDFTSSALRCKELRQKVGAVRAETAAPATPAVNK [2] 1.9e-18 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++++++++++++++++++ + ++ 76 SSSEGKKTLRKGNVVITGASSGLGLATAKALAESGKWHVIMACRDYLKAARAAKSAGLAKENYTIMHLDLASLDS DHCA_HUMAN no comment LENGTH = 276 COMBINED P-VALUE = 3.43e-19 E-VALUE = 1.1e-17 DIAGRAM: 4_[2]_159_[1]_55 [2] 4.0e-16 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++++++++++++++++++++ + ++ 1 SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDF [1] 2.9e-10 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++ ++ +++ +++ +++ +++++ +++ 151 PELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC ADH_DROME ALCOHOL DEHYDROGENASE (EC 1.1.1.1) LENGTH = 255 COMBINED P-VALUE = 8.17e-16 E-VALUE = 2.7e-14 DIAGRAM: 6_[2]_116_[1]_75 [2] 1.1e-10 KVVLITGCSSGIGKATAKHLHKEGAKVVL ++++ + +++++ + ++++++ + + 1 SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKL [1] 3.6e-12 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++ ++++++++++++++ ++++ +++ 151 VYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKA MAS1_AGRRA no comment LENGTH = 476 COMBINED P-VALUE = 9.22e-16 E-VALUE = 3e-14 DIAGRAM: 245_[2]_74_[1]_14_[1]_56 [2] 2.9e-15 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++ + +++ ++++++++++++++ + 226 GRVLHFRRGFSHWTVEIHQSPVILVSGSNRGVGKAIAEDLIAHGYRLSLGARKVKDLEVAFGPQDEWLHYARFDA [1] 4.0e-08 YSASKFAVRMLTRSMAHEYAPHGIRVN + + + +++ ++ + +++ +++ 301 EDHGTMAAWVTAAVEKFGRIDGLVNNAGYGEPVNLDKHVDYQRFHLQWYINCVAPLRMTELCLPHLYETGSGRIV [1] 8.7e-05 CI YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++ + +++ ++ +++++ ++ + + 376 NINSMSGQRVLNPLVGYNMTKHALGGLTKTTQHVGWDRRCAAIDICLGFVATDMSAWTDLIASKDMIQPEDIAKL FABI_ECOLI no comment LENGTH = 262 COMBINED P-VALUE = 2.94e-15 E-VALUE = 9.7e-14 DIAGRAM: 6_[2]_123_[1]_75 [2] 4.5e-10 KVVLITGCSSGIGKATAKHLHKEGAKVVL +++++++ ++ + ++ ++ +++ + 1 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMF [1] 3.1e-12 YSASKFAVRMLTRSMAHEYAPHGIRVNCI ++ +++++++ +++++ +++++++++++ 151 RAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDV CSGA_MYXXA no comment LENGTH = 166 COMBINED P-VALUE = 7.50e-14 E-VALUE = 2.5e-12 DIAGRAM: 51_[2]_7_[1]_50 [2] 9.0e-08 KVVLITGCSSGIGKATAKHLHKEG + ++ + ++ + +++ +++ 1 MRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMG [1] 1.3e-12 AKVVL YSASKFAVRMLTRSMAHEYAPHGIRVNCI + + ++++++ + ++++ ++++++ + + + 76 SLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNP ******************************************************************************** CPU: pmgm2 Time 0.250000 secs. mast meme.adh.oops.txt -text -stdout