# Copyright 2003, 2007 by Sebastian Bassi. sbassi@genesdigitales.com
# All rights reserved.  This code is part of the Biopython
# distribution and governed by its license.
# Please see the LICENSE file that should have been included as part
# of this package.

import math


def lcc_mult(seq, wsize):
    """Local Composition Complexity (LCC) values over sliding window.

    Returns a list of floats, the LCC values for a sliding window over
    the sequence.

    seq - an unambiguous DNA sequence (a string or Seq object)
    wsize - window size, integer

    The result is the same as applying lcc_simp multiple times, but this
    version is optimized for speed. The optimization works by using the
    value of previous window as a base to compute the next one."""
    l2 = math.log(2)
    tamseq = len(seq)
    try:
        #Assume its a string
        upper = seq.upper()
    except AttributeError:
        #Should be a Seq object then
        upper = str(seq).upper()
    compone = [0]
    lccsal = [0]
    for i in range(wsize):
        compone.append(((i+1)/float(wsize))*
                       ((math.log((i+1)/float(wsize)))/l2))
    window = seq[0:wsize]
    cant_a = window.count('A')
    cant_c = window.count('C')
    cant_t = window.count('T')
    cant_g = window.count('G')
    term_a = compone[cant_a]
    term_c = compone[cant_c]
    term_t = compone[cant_t]
    term_g = compone[cant_g]
    lccsal.append(-(term_a+term_c+term_t+term_g))
    tail = seq[0]
    for x in range(tamseq-wsize):
        window = upper[x+1:wsize+x+1]
        if tail == window[-1]:
            lccsal.append(lccsal[-1])
        elif tail == 'A':
            cant_a -= 1
            if window.endswith('C'):
                cant_c += 1
                term_a = compone[cant_a]
                term_c = compone[cant_c]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('T'):
                cant_t += 1
                term_a = compone[cant_a]
                term_t = compone[cant_t]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('G'):
                cant_g += 1
                term_a = compone[cant_a]
                term_g = compone[cant_g]
                lccsal.append(-(term_a+term_c+term_t+term_g))
        elif tail == 'C':
            cant_c -= 1
            if window.endswith('A'):
                cant_a += 1
                term_a = compone[cant_a]
                term_c = compone[cant_c]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('T'):
                cant_t += 1
                term_c = compone[cant_c]
                term_t = compone[cant_t]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('G'):
                cant_g += 1
                term_c = compone[cant_c]
                term_g = compone[cant_g]
                lccsal.append(-(term_a+term_c+term_t+term_g))
        elif tail == 'T':
            cant_t -= 1
            if window.endswith('A'):
                cant_a += 1
                term_a = compone[cant_a]
                term_t = compone[cant_t]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('C'):
                cant_c += 1
                term_c = compone[cant_c]
                term_t = compone[cant_t]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('G'):
                cant_g += 1
                term_t = compone[cant_t]
                term_g = compone[cant_g]
                lccsal.append(-(term_a+term_c+term_t+term_g))
        elif tail == 'G':
            cant_g -= 1
            if window.endswith('A'):
                cant_a += 1
                term_a = compone[cant_a]
                term_g = compone[cant_g]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('C'):
                cant_c += 1
                term_c = compone[cant_c]
                term_g = compone[cant_g]
                lccsal.append(-(term_a+term_c+term_t+term_g))
            elif window.endswith('T'):
                cant_t += 1
                term_t = compone[cant_t]
                term_g = compone[cant_g]
                lccsal.append(-(term_a+term_c+term_t+term_g))
        tail = window[0]
    return lccsal


def lcc_simp(seq):
    """Local Composition Complexity (LCC) for a sequence.

    seq - an unambiguous DNA sequence (a string or Seq object)

    Returns the Local Composition Complexity (LCC) value for the entire
    sequence (as a float).

    Reference:
    Andrzej K Konopka (2005) Sequence Complexity and Composition
    DOI: 10.1038/npg.els.0005260
    """
    wsize = len(seq)
    try:
        #Assume its a string
        upper = seq.upper()
    except AttributeError:
        #Should be a Seq object then
        upper = str(seq).upper()
    l2 = math.log(2)
    if 'A' not in seq:
        term_a = 0
        # Check to avoid calculating the log of 0.
    else:
        term_a = ((upper.count('A'))/float(wsize))*((math.log((upper.count('A'))
                                                          /float(wsize)))/l2)
    if 'C' not in seq:
        term_c = 0
    else:
        term_c = ((upper.count('C'))/float(wsize))*((math.log((upper.count('C'))
                                                          /float(wsize)))/l2)
    if 'T' not in seq:
        term_t = 0
    else:
        term_t = ((upper.count('T'))/float(wsize))*((math.log((upper.count('T'))
                                                          /float(wsize)))/l2)
    if 'G' not in seq:
        term_g = 0
    else:
        term_g = ((upper.count('G'))/float(wsize))*((math.log((upper.count('G'))
                                                          /float(wsize)))/l2)
    return -(term_a+term_c+term_t+term_g)