rms.curv package:MASS R Documentation _R_e_l_a_t_i_v_e _C_u_r_v_a_t_u_r_e _M_e_a_s_u_r_e_s _f_o_r _N_o_n-_L_i_n_e_a_r _R_e_g_r_e_s_s_i_o_n _D_e_s_c_r_i_p_t_i_o_n: Calculates the root mean square parameter effects and intrinsic relative curvatures, c^theta and c^iota, for a fitted nonlinear regression, as defined in Bates & Watts, section 7.3, p. 253 et seq. _U_s_a_g_e: rms.curv(obj) _A_r_g_u_m_e_n_t_s: obj: Fitted model object of class '"nls"'. The model must be fitted using the default algorithm. _D_e_t_a_i_l_s: The method of section 7.3.1 of Bates & Watts is implemented. The function 'deriv3' should be used generate a model function with first derivative (gradient) matrix and second derivative (Hessian) array attributes. This function should then be used to fit the nonlinear regression model. A print method, 'print.rms.curv', prints the 'pc' and 'ic' components only, suitably annotated. If either 'pc' or 'ic' exceeds some threshold (0.3 has been suggested) the curvature is unacceptably high for the planar assumption. _V_a_l_u_e: A list of class 'rms.curv' with components 'pc' and 'ic' for parameter effects and intrinsic relative curvatures multiplied by sqrt(F), 'ct' and 'ci' for c^theta and c^iota (unmultiplied), and 'C' the C-array as used in section 7.3.1 of Bates & Watts. _R_e_f_e_r_e_n_c_e_s: Bates, D. M, and Watts, D. G. (1988) _Nonlinear Regression Analysis and its Applications._ Wiley, New York. _S_e_e _A_l_s_o: 'deriv3' _E_x_a_m_p_l_e_s: # The treated sample from the Puromycin data mmcurve <- deriv3(~ Vm * conc/(K + conc), c("Vm", "K"), function(Vm, K, conc) NULL) Treated <- Puromycin[Puromycin$state == "treated", ] (Purfit1 <- nls(rate ~ mmcurve(Vm, K, conc), data = Treated, start = list(Vm=200, K=0.1))) rms.curv(Purfit1) ##Parameter effects: c^theta x sqrt(F) = 0.2121 ## Intrinsic: c^iota x sqrt(F) = 0.092