Cefamandole               package:nlme               R Documentation

_P_h_a_r_m_a_c_o_k_i_n_e_t_i_c_s _o_f _C_e_f_a_m_a_n_d_o_l_e

_D_e_s_c_r_i_p_t_i_o_n:

     The 'Cefamandole' data frame has 84 rows and 3 columns.

_F_o_r_m_a_t:

     This data frame contains the following columns:

     _S_u_b_j_e_c_t a factor giving the subject from which the sample was
          drawn.

     _T_i_m_e a numeric vector giving the time at which the sample was
          drawn (minutes post-injection).

     _c_o_n_c a numeric vector giving the observed plasma concentration of
          cefamandole (mcg/ml).


_D_e_t_a_i_l_s:

     Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained
     during a pilot study to investigate the pharmacokinetics of the
     drug cefamandole. Plasma concentrations of the drug were measured
     on six healthy volunteers at 14 time points following an
     intraveneous dose of 15 mg/kg body weight of cefamandole.

_S_o_u_r_c_e:

     Pinheiro, J. C. and Bates, D. M. (2000), _Mixed-Effects Models in
     S and S-PLUS_, Springer, New York.  (Appendix A.4)

     Davidian, M. and Giltinan, D. M. (1995), _Nonlinear Models for
     Repeated Measurement Data_,  Chapman and Hall, London.

_E_x_a_m_p_l_e_s:

     plot(Cefamandole)
     fm1 <- nlsList(SSbiexp, data = Cefamandole)
     summary(fm1)