phenoModel               package:nlme               R Documentation

_M_o_d_e_l _f_u_n_c_t_i_o_n _f_o_r _t_h_e _P_h_e_n_o_b_a_r_b _d_a_t_a

_D_e_s_c_r_i_p_t_i_o_n:

     A model function for a model used with the 'Phenobarb' data. This
     function uses compiled C code to improve execution speed.

_U_s_a_g_e:

     phenoModel(Subject, time, dose, lCl, lV)

_A_r_g_u_m_e_n_t_s:

 Subject: an integer vector of subject identifiers.  These should be
          sorted in increasing order.

    time: numeric. A vector of the times at which the sample was drawn
          or the drug administered (hr). 

    dose: numeric. A vector of doses of drug administered (mug/kg). 

     lCl: numeric.  A vector of values of the natural log of the
          clearance parameter according to 'Subject' and 'time'.

      lV: numeric.  A vector of values of the natural log of the
          effective volume of distribution according to 'Subject' and
          'time'.

_D_e_t_a_i_l_s:

     See the details section of 'Phenobarb' for a description of the
     model function that 'phenoModel' evaluates.

_V_a_l_u_e:

     a numeric vector of predicted phenobarbital concentrations.

_A_u_t_h_o_r(_s):

     Jose Pinheiro jose.pinheiro@pharma.novartis.com and Douglas Bates
     bates@stat.wisc.edu

_R_e_f_e_r_e_n_c_e_s:

     Pinheiro, J. C. and Bates, D. M. (2000) _Mixed-effects Models in S
     and S-PLUS_, Springer. (section 6.4)