SSbiexp package:stats R Documentation _B_i_e_x_p_o_n_e_n_t_i_a_l _m_o_d_e_l _D_e_s_c_r_i_p_t_i_o_n: This 'selfStart' model evaluates the biexponential model function and its gradient. It has an 'initial' attribute that creates initial estimates of the parameters 'A1', 'lrc1', 'A2', and 'lrc2'. _U_s_a_g_e: SSbiexp(input, A1, lrc1, A2, lrc2) _A_r_g_u_m_e_n_t_s: input: a numeric vector of values at which to evaluate the model. A1: a numeric parameter representing the multiplier of the first exponential. lrc1: a numeric parameter representing the natural logarithm of the rate constant of the first exponential. A2: a numeric parameter representing the multiplier of the second exponential. lrc2: a numeric parameter representing the natural logarithm of the rate constant of the second exponential. _V_a_l_u_e: a numeric vector of the same length as 'input'. It is the value of the expression 'A1*exp(-exp(lrc1)*input)+A2*exp(-exp(lrc2)*input)'. If all of the arguments 'A1', 'lrc1', 'A2', and 'lrc2' are names of objects, the gradient matrix with respect to these names is attached as an attribute named 'gradient'. _A_u_t_h_o_r(_s): Jose Pinheiro and Douglas Bates _S_e_e _A_l_s_o: 'nls', 'selfStart' _E_x_a_m_p_l_e_s: Indo.1 <- Indometh[Indometh$Subject == 1, ] SSbiexp( Indo.1$time, 3, 1, 0.6, -1.3 ) # response only A1 <- 3; lrc1 <- 1; A2 <- 0.6; lrc2 <- -1.3 SSbiexp( Indo.1$time, A1, lrc1, A2, lrc2 ) # response and gradient getInitial(conc ~ SSbiexp(time, A1, lrc1, A2, lrc2), data = Indo.1) ## Initial values are in fact the converged values fm1 <- nls(conc ~ SSbiexp(time, A1, lrc1, A2, lrc2), data = Indo.1) summary(fm1)