bladder               package:survival               R Documentation

_B_l_a_d_d_e_r _C_a_n_c_e_r _R_e_c_u_r_r_e_n_c_e_s

_D_e_s_c_r_i_p_t_i_o_n:

     Data on recurrences of bladder cancer, used by many people to
     demonstrate methodology for recurrent event modelling.

     Bladder1 is the full data set from the study. It contains all
     three treatment arms and all recurrences for 118 subjects; the
     maximum observed number of recurrences is 9.

     Bladder is the data set that appears most commonly in the
     literature.  It uses only the 85 subjects with nonzero follow-up
     who were assigned to either thiotepa or placebo.  The status
     variable is 1 for recurrence and 0 for everything else (including
     death for any reason). The data set is laid out in the competing
     risks format of the paper by Wei, Lin, and Weissfeld.

     Bladder2 uses the same subset of subjects as bladder, but formated
     in the (start, stop] or Anderson-Gill style.   Note that in
     transforming from the WLW to the AG style data set there is a
     quite common programming mistake that leads to extra follow-up
     time for 12 subjects (all those with more than 4 recurrences);
     this includes some earlier releases of the data in R.

_U_s_a_g_e:

     bladder1
     bladder
     bladder2

_F_o_r_m_a_t:

     bladder1

       id:          Patient id
       treatment:   Placebo, pyridoxine (vitamin B6), or thiotepa
       number:      Initial number of tumours (8=8 or more)
       size:        Size (cm) of largest initial tumour
       recur:       Number of recurrences
       start,stop:  The start and end time of each time interval
       status:      End of interval code, 0=censored, 1=recurrence,
                    2=death from bladder disease, 3=death other/unknown cause
       rtumor:      Number of tumors found at the time of a recurrence
       rsize:       Size of largest tumor at a recurrence
       enum:        Event number (observation number within patient)

     bladder

       id:      Patient id
       rx:      Treatment 1=placebo  2=thiotepa
       number:  Initial number of tumours (8=8 or more)
       size:    size (cm) of largest initial tumour
       stop:    recurrence or censoring time
       enum:    which recurrence (up to 4)

     bladder2 

       id:      Patient id
       rx:      Treatment 1=placebo  2=thiotepa
       number:  Initial number of tumours (8=8 or more)
       size:    size (cm) of largest initial tumour
       start:   start of interval (0 or previous recurrence time)
       stop:    recurrence or censoring time
       enum:    which recurrence (up to 4)

_S_o_u_r_c_e:

     Andrews DF, Hertzberg AM (1985),  DATA: A Collection of Problems
     from Many Fields for the Student  and Research Worker, New York:
     Springer-Verlag.

     LJ Wei, DY Lin, L Weissfeld (1989), Regression analysis of
     multivariate incomplete failure time data by modeling marginal
     distributions. _Journal of the American Statistical Association_,
     *84*.