pbc                 package:survival                 R Documentation

_M_a_y_o _C_l_i_n_i_c _P_r_i_m_a_r_y _B_i_l_i_a_r_y _C_i_r_r_h_o_s_i_s _D_a_t_a

_D_e_s_c_r_i_p_t_i_o_n:

     D This data is from the Mayo Clinic trial in primary biliary
     cirrhosis (PBC) of the liver conducted between 1974 and 1984.   A
     total of 424 PBC patients, referred to Mayo Clinic during that
     ten-year interval, met eligibility criteria for the randomized
     placebo controlled trial of the drug D-penicillamine.  The first
     312 cases in the data set participated in the randomized trial and
     contain largely complete data.  The additional 112 cases did not
     participate in the clinical trial, but consented to have basic
     measurements recorded and to be followed for survival.  Six of
     those cases were lost to follow-up shortly after diagnosis, so the
     data here are on an additional 106 cases as well as the 312
     randomized participants.

     A nearly identical data set found in appendix D of Fleming and
     Harrington; this version has fewer missing values.

_U_s_a_g_e:

     pbc

_F_o_r_m_a_t:


       age:       in years
       albumin:   serum albumin (mg/dl)
       alk.phos:  alkaline phosphotase (U/liter)
       ascites:   presence of ascites
       ast:       aspartate aminotransferase, once called SGOT (U/ml)
       bili:      serum bilirunbin (mg/dl)
       chol:      serum cholesterol (mg/dl)
       copper:    urine copper (ug/day)
       edema:     0 no edema, 0.5 untreated or successfully treated
                  1 edema despite diuretic therapy
       hepato:    presence of hepatomegaly or enlarged liver
       id:        case number
       platelet:  platelet count
       protime:   standardised blood clotting time
       sex:       m/f
       spiders:   blood vessel malformations in the skin
       stage:     histologic stage of disease (needs biopsy)
       status:    status at endpoint, 0/1/2 for censored, transplant, dead
       time:      number of days between registration and the earlier of death,
                  transplantion, or study analysis in July, 1986
       trt:       1/2/NA for D-penicillmain, placebo, not randomised
       trig:      triglycerides (mg/dl)

_S_o_u_r_c_e:

     T Therneau and P Grambsch (2000), _Modeling Survival Data:
     Extending the Cox Model_, Springer-Verlag, New York. ISBN:
     0-387-98784-3.