Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis SM00283 Laminin-type epidermal growth factor-like domai SM00180 Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases SM00176 Integrin beta subunits (N-terminal portion of extracellular region) SM00187 eukaryotic translation initiation factor 1A SM00652 Band 4.1 homologues SM00295 Ricin-type beta-trefoil SM00458 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases SM00698 Kelch domain SM00612 RNA recognition motif SM00360 prohibitin homologues SM00244 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins SM00714 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen SM00559 Interferon alpha, beta and delta. Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon SM00076 PAS domain SM00091 Sigma factor PP2C-like phosphatases SM00331 DNA-directed RNA-polymerase II subunit SM00657 Short calmodulin-binding motif containing conserved Ile and Gln residues. Calmodulin-binding motif SM00015 Staphylococcal nuclease homologues SM00318 Serine/threonine phosphatases, family 2C, catalytic domain SM00332 leucine rich region SM00431 ARF-like small GTPases SM00177 Connexin homologues SM00037 Phosphoinositide 3-kinase, region postulated to contain C2 domain SM00142 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of th SM00291 ADAM Cysteine-Rich Domain SM00608 A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins SM00538 Domain B in dwarfin family proteins SM00524 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241 SM00685 Helical region found in SNAREs SM00397 5'-3' exonuclease SM00475 Osteopontin SM00017 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts SM00554 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). SM00199 BCL (B-Cell lymphoma) SM00337 domain in protein kinases, N-glycanases and other nuclear proteins SM00580 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria SM00712 calpain_III domain SM00720 Protein phosphatase 2A homologues, catalytic domain SM00156 Chitin-binding domain type 2 SM00494 DEAD-like helicases superfamily SM00487 Thyroglobulin type I repeats SM00211 Four-disulfide core domains SM00217 Histidine kinase-like ATPases SM00387 tob/btg1 family SM00099 basic region leucin zipper SM00338 Parathyroid hormone SM00087 Pentraxin / C-reactive protein / pentaxin family SM00159 Spectrin repeats SM00150 Glucagon like hormones SM00070 Low-density lipoprotein-receptor YWTD domain SM00135 K homology RNA-binding domain SM00322 present in yeast cell wall integrity and stress response component proteins SM00321 Serum amyloid A proteins SM00197 Colipase SM00023 Actin depolymerisation factor/cofilin -like domains SM00102 Domain associated with PX domains SM00313 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein SM00042 domain found in Plexins, Semaphorins and Integrins SM00423 Galectin SM00276 Filamin-type immunoglobulin domains SM00557 Helix-hairpin-helix class 2 (Pol1 family) motifs SM00279 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) SM00034 UAS domain SM00594 Ras association (RalGDS/AF-6) domain SM00314 in nuclear membrane-associated proteins SM00540 B-Box-type zinc finger SM00336 uanine nucleotide exchange factor for Ras-like GTPases SM00229 Epsin N-terminal homology (ENTH) domain SM00273 Cold shock protein domain SM00357 gastrin / cholecystokinin / caerulein family SM00029 putative band 4.1 homologues' binding motif SM00294 Zinc finger in DBF-like proteins SM00586 Ubiquitin associated domain SM00165 Wiskott Aldrich syndrome homology region 2 SM00246 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the t SM00665 Domain present in phytochromes and cGMP-specific phosphodiesterases. Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa SM00065 Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain SM00462 PB1 domain SM00666 Sec7 domain SM00222 Transcription initiation factor IIE SM00531 krueppel associated box SM00349 LCCL domain SM00603 DNA polymerase type-B family SM00486 Ribosomal protein L11/L12 SM00649 WD40 repeats SM00320 domain present in translation initiation factor eIF2B and eIF5 SM00653 Sterile alpha motif SM00454 Thyroglobulin type I repeats. SM00211 BPTI/Kunitz family of serine protease inhibitors SM00131 Chromo Shadow Domain SM00300 membrane-attack complex / perforin SM00457 GTPase-activator protein for Ras-like GTPases SM00323 Beta/gamma crystallins SM00247 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and ha SM00442 Glycoprotein hormone alpha chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology SM00067 Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 SM00707 Acid phosphatase homologues SM00014 associated with SPRY domains SM00589 ARID (A/T-rich interaction domain) domain SM00501 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC) SM00199 Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK SM00692 HAT (Half-A-TPR) repeats SM00386 serum albumin SM00103 domain in chromatin remodeling S1 domain containing proteins and zinc fingers SM00578 E-Z type HEAT repeats SM00567 HNH nucleases SM00507 Saposins-like type B SM00118 Domain A in dwarfin family proteins SM00523 Domain in the Doublecortin (DCX) gene product SM00537 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine SM00701 Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb SM00079 Calponin homology domain SM00033 Interleukins 4 and 13 SM00190 PhoX homologous domain, present in p47phox and p40phox SM00312 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins SM00706 Doublesex DNA-binding motif SM00301 Galanin SM00071 Putative single-stranded nucleic acids-binding domain SM00393 Histone 2A SM00414 Myelin proteolipid protein (PLP or lipophilin) SM00002 Frizzled SM00063 Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 SM00561 Cytoplasmic phospholipase A2, catalytic subunit SM00022 DNA/RNA non-specific endonuclease SM00477 Domain found in Notch and Lin-12 SM00004 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains SM00717 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) SM00109 Guanylate kinase homologues. Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities SM00072 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epileps SM00724 3'-5' exonuclease SM00474 Large family of predicted nucleotide-binding domains SM00670 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th SM00693 Fibrillar collagens C-terminal domain SM00038 Kinesin motor, catalytic domain. ATPase SM00129 Found in Pit-Oct-Unc transcription factors SM00352 Ribosomal RNA adenine dimethylases SM00650 Protein kinase C conserved region 2 (CalB) SM00239 Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis SM00678 Domain in DAP-5, eIF4G, MA-3 and other proteins SM00544 G-protein-coupled receptor proteolytic site domain SM00303 Tumour necrosis factor family SM00207 BAG domains, present in regulator of Hsp70 proteins SM00264 Juvenile hormone binding protein domains in insects SM00700 Ribosomal protein S1-like RNA-binding domain SM00316 Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins SM00555 Clathrin heavy chain repeat homology SM00299 Interleukin-7 and interleukin-9 family. IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its functio SM00127 Hint (Hedgehog/Intein) domain N-terminal region SM00306 In Between Ring fingers SM00647 zinc finger SM00356 Dynamin GTPase effector domain SM00302 Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family SM00141 Interleukin-6 homologues SM00126 "FY-rich" domain, N-terminal region SM00541 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-f SM00191 A domain family that is part of the cupin metalloenzyme superfamily. Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes SM00558 Follistatin-N-terminal domain-like SM00274 Zinc-dependent metalloprotease SM00235 JAB/MPN domain SM00232 Armadillo/beta-catenin-like repeats SM00185 Guanylate kinase homologues SM00072 Fibrinogen-related domains (FReDs) SM00186 14-3-3 homologues SM00101 Orange domain SM00511 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of met SM00120 Short conserved domain in transcriptional regulators SM00719 Appr-1"-p processing enzyme SM00506 SERine Proteinase INhibitors SM00093 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglu SM00702 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of t SM00110 WAP domain SM00217 Wnt-inhibitory factor-1 like domain SM00469 Thyroglobulin type I repeats. The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin SM00211 Domain abundant in complement control proteins SM00032 Bacterial periplasmic substrate-binding proteins SM00062 Xeroderma pigmentosum G N-region SM00485 minichromosome maintenance proteins SM00350 Lipoxygenase homology 2 (beta barrel) domain SM00308 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases SM00325 Caspase recruitment domain SM00114 Domains in Na-Ca exchangers and integrin-beta4 SM00237 DNA-binding domain of DNA mismatch repair MUTS family SM00533 Formin Homology 2 Domain SM00498 Plectin repeat SM00250 Thymosin beta actin-binding motif SM00152 Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function SM00684 calcitonin SM00113 Ligase N family SM00532 BAR domain SM00721 breast cancer carboxy-terminal domain SM00292 Zona pellucida (ZP) domain SM00241 RNA polymerase I subunit A N-terminus SM00663 APPLE domain SM00223 Hint (Hedgehog/Intein) domain C-terminal region SM00305 TEA domain SM00426 Hemopexin-like repeats SM00120 "FY-rich" domain, C-terminal region SM00542 heat shock factor SM00415 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase SM00359 erine/Threonine protein kinases, catalytic domain SM00220 Ubiquitin-conjugating enzyme E2, catalytic domain homologues SM00212 tail specific protease SM00245 Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) SM00509 BPTI/Kunitz family of serine protease inhibitors. Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein SM00131 domain present in cyclins, TFIIB and Retinoblastoma SM00385 Domain in Myosin and Kinesin Tails SM00139 Calpain-like thiol protease family SM00230 Transthyretin SM00095 C2C2 Zinc finger SM00440 Middle domain of eukaryotic initiation factor 4G (eIF4G) SM00543 Pleiotrophin / midkine family SM00193 MADS domain SM00432 domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins SM00568 domain in neuralized proteins SM00588 Immunoreceptor tyrosine-based activation motif SM00077 Tumor necrosis factor receptor / nerve growth factor receptor repeats. Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR SM00208 Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) SM00137 Domain in SOG (short gastrulation protein) and chordin SM00566 Juvenile hormone binding protein domains in insects. The juvenile hormone exerts pleiotropic functions during insect life cycles and its binding proteins regulate these functions SM00700 Domain present in VPS9 SM00167 Sel1-like repeats SM00671 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at present SM00664 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are as SM00116 Contains two conserved F residues SM00441 domain in high mobilty group proteins HMG14 and HMG 17 SM00527 factor I membrane attack complex SM00057 Extension to Ser/Thr-type protein kinases SM00133 TopoisomeraseII SM00433 Insulin / insulin-like growth factor / relaxin family. SM00078 Alpha-lactalbumin / lysozyme C SM00263 Glycoprotein hormone beta chain homologues SM00068 Zinc-binding domain, present in Dystrophin, CREB-binding protein. Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. The ZZ in dystrophin appears to bind calmodulin. A missense mutation of one of t SM00291 CDGSH-type zinc finger. Function unknown SM00704 Phosphotyrosine-binding domain (IRS1-like) SM00310 Cyclic nucleotide-monophosphate binding domain SM00100 Domain with 2 conserved Trp (W) residues SM00456 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases SM00472 Protein tyrosine phosphatase, catalytic domain SM00194 Actin SM00268 WASP homology region 1 SM00461 RNA polymerase subunit CX SM00659 TAF homology SM00549 zinc finger in transposases and transcription factors SM00597 Broad-Complex, Tramtrack and Bric a brac SM00225 Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglut SM00702 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain SM00042 Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) SM00546 RIO-like kinase SM00090 Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the tw SM00665 Profilin SM00392 Bromo adjacent homology domain SM00439 N-terminal to some SET domains SM00468 Ran-binding domain SM00160 Domain in SPla and the RYanodine Receptor. SM00449 Calpain-like thiol protease family. SM00230 exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases SM00479 Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are ass SM00116 Sar1p-like members of the Ras-family of small GTPases SM00178 C-terminal tandem repeated domain in type 4 procollagens SM00111 Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and h SM00442 Fibronectin type 3 domain SM00060 leukemia inhibitory factor SM00080 Saposin/surfactant protein-B A-type DOMAIN SM00162 Tudor domain SM00333 Small MutS-related domain SM00463 Phospholipase D. Active site motifs SM00155 Ependymins SM00026 Rho (Ras homology) subfamily of Ras-like small GTPases SM00174 Calpain-like thiol protease family. Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit) SM00230 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs SM00164 Interleukin-2 family SM00189 Eps15 homology domain SM00027 von Willebrand factor (vWF) type D domain SM00216 Laminin B domain SM00281 EF-hand, calcium binding motif SM00054 Domain present in VPS-27, Hrs and STAM SM00288 ShK toxin domain SM00254 domain in splicing factors SM00311 Thrombospondin N-terminal -like domains. Heparin-binding and cell adhesion domain of thrombospondin SM00210 Tumour necrosis factor family. Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor SM00207 Prolyl 4-hydroxylase alpha subunit homologues SM00702 Vault protein Inter-alpha-Trypsin domain SM00609 Protein tyrosine phosphatase, catalytic domain motif SM00404 Cytochrome b-561 / ferric reductase transmembrane domain SM00665 BPI/LBP/CETP N-terminal domain SM00328 PhoX homologous domain, present in p47phox and p40phox. Eukaryotic domain of unknown function present in phox proteins, PLD isoforms, a PI3K isoform SM00312 Dysferlin domain, C-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict th SM00694 I/LWEQ domain SM00307 Domain in the central regions of transcription elongation factor S-II (and elsewhere) SM00510 Lipoprotein N-terminal Domain SM00638 Ligand binding domain of hormone receptors SM00430 high mobility group SM00398 Domain present in ubiquitin-regulatory proteins SM00166 Pancreatic hormones / neuropeptide F / peptide YY family SM00309 Tumor necrosis factor receptor / nerve growth factor receptor repeats SM00208 Insulin / insulin-like growth factor / relaxin family. Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration SM00078 Immunoglobulin SM00409 Hemopexin-like repeats. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of me SM00120 Bromodomain transcription factors and PHD domain containing proteins SM00576 PI3-kinase family, p85-binding domain SM00143 found in Wnt-1 SM00097 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at presen SM00664 Nerve growth factor (NGF or beta-NGF) SM00140 helix loop helix domain SM00353 Gelsolin homology domain SM00262 Uteroglobin SM00096 RNA polymerases D SM00662 Natriuretic peptide SM00183 motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 SM00088 Protein kinase C-related kinase homology region 1 homologues SM00074 Metal dependent phosphohydrolases with conserved 'HD' motif SM00471 Domain of unknown function present in FAF1 (Fas-associated factor 1) SM00553 Complement component C1q domain. Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tu SM00110 DNA polymerase X family SM00483 Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 SM00036 c4 zinc finger in nuclear hormone receptors SM00399 Annexin repeats SM00335 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. Function unknown, but likely to be associated with the glycosylation machinery SM00679 Cysteine-rich motif following a subset of SET domains SM00508 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted d SM00233 glycine rich nucleic binding domain SM00443 Cadherin repeats. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium SM00112 C-terminal to LisH motif. SM00668 Alkaline phosphatase homologues SM00098 Coagulation factor 5/8 C-terminal domain, discoidin domain SM00231 U1-like zinc finger SM00451 Dysferlin domain, N-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the SM00693 deoxyribonuclease I SM00476 GS motif SM00467 BPI/LBP/CETP C-terminal domain SM00329 Netrin C-terminal Domain SM00643 translation initiation factor 6 SM00654 Dynamin, GTPase SM00053 Fibronectin type 2 domain SM00059 helicase superfamily c-terminal domain SM00490 Glycoprotein hormone beta chain homologues. Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology SM00068 Low-density lipoprotein receptor domain class A SM00192 Src homology 2 domains SM00252 endonuclease III SM00478 Raf-like Ras-binding domain SM00455 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no SM00198 Ribonuclease III family SM00535 Short calmodulin-binding motif containing conserved Ile and Gln residues SM00015 Guanine nucleotide exchange factor for Ras-like small GTPases SM00147 von Willebrand factor (vWF) type C domain SM00214 Zinc finger domain SM00547 FORKHEAD SM00339 Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences SM00671 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger SM00290 Ring finger SM00184 Homeodomain SM00389 Tissue inhibitor of metalloproteinase family. Form complexes with metalloproteinases, such as collagenases, and irreversibly inactivate them SM00206 Double-stranded RNA binding motif SM00358 Chromatin organization modifier domain SM00298 Anaphylatoxin homologous domain SM00104 Zinc-binding domain, present in Dystrophin, CREB-binding protein SM00291 domain in helicases and associated with SANT domains SM00573 Domain first found in the mice T locus (Brachyury) protein SM00425 domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain SM00591 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain SM00317 Zn_pept domain SM00631 Phospholipase D. Active site motifs. Phosphatidylcholine-hydrolyzing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of cert SM00155 Lissencephaly type-1-like homology motif SM00667 Sorbin homologous domain SM00459 P21-Rho-binding domain SM00285 Major prion protein SM00157 Papain family cysteine protease SM00645 Sar1p-like members of the Ras-family of small GTPases SM00178 Scavenger receptor Cys-rich SM00202 Adhesion-associated domain present in MUC4 and other proteins SM00723 Ami_2 domain SM00644 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylate SM00454 Epidermal growth factor-like domain SM00181 Ras subfamily of RAS small GTPases SM00173 Rab subfamily of small GTPases SM00175 Transforming growth factor-beta (TGF-beta) family SM00204 Cullin SM00182 A20-like zinc fingers SM00259 Lysin motif SM00257 PHD zinc finger SM00249 Cadherin repeats SM00112 delta serrate ligand SM00051 S4 RNA-binding domain SM00363 Diacylglycerol kinase accessory domain (presumed) SM00045 Helix-turn-helix XRE-family like proteins SM00530 Domain present in hormone receptors SM00008 G protein alpha subunit SM00275 Protein phosphatase 2A homologues, catalytic domain. Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members SM00156 Granulin SM00277 Bruton's tyrosine kinase Cys-rich motif SM00107 Kinesin motor, catalytic domain. ATPase. Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division SM00129 DNA Topoisomerase IV SM00434 Repeats found in several Drosophila proteins SM00697 RRM_1 domain SM00361 Paired Box domain SM00351 Zinc-binding domain present in Lin-11, Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways SM00132 Zinc-binding domain present in Lin-11, Isl-1, Mec-3 SM00132 domain in receptor targeting proteins Lin-2 and Lin-7 SM00569 Fes/CIP4 homology domain SM00055 Domain of unknown function in Sec63p, Brr2p and other proteins SM00611 Fibronectin type 1 domain SM00058 Leucine-rich repeats, typical (most populated) subfamily SM00369 Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides SM00228 RNA polymerase subunit 8 SM00658 RNA polymerase subunit 9 SM00661 Thrombospondin type 1 repeats SM00209 Myosin. Large ATPases. ATPase SM00242 Putative DNA-binding domain in centromere protein B, mouse jerky and transposases SM00674 BH4 Bcl-2 homology region 4 SM00265 Histone H2B SM00427 Dysferlin domain, C-terminal region. Domain of unknown function present in yeast peroxisomal proteins, dysferlin, myoferlin and hypothetical proteins. Due to an insertion of a dysferlin domain within a second dysferlin domain we have chosen to predict the SM00694 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) SM00086 Glyco_18 domain SM00636 Villin headpiece domain SM00153 Phospholipase C, catalytic domain (part) SM00148 Src homology 3 domains SM00326 N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4). Also present in several other worm and fly proteins SM00703 Trypsin-like serine protease SM00020 occurring C-terminal to leucine-rich repeats SM00446 Phosphoinositide 3-kinase, catalytic domain SM00146 Syntaxin N-terminal domain SM00503 domain in Ataxins and HMG containing proteins SM00536 Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation SM00513 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3) SM00525 ZnF_C4 abd HLH domain containing kinases domain SM00587 Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product SM00673 Furin-like repeats SM00261 Repeats in polycystic kidney disease 1 (PKD1) and other proteins SM00089 Domain present in PSD-95, Dlg, and ZO-1/2 SM00228 beta-propeller repeat SM00564 P or trefoil or TFF domain SM00018 Ubiquitin homologues SM00213 Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response SM00199 in StAR and phosphatidylcholine transfer protein SM00234 Integrin alpha (beta-propellor repeats) SM00191 Serine/Threonine protein kinases, catalytic domain SM00220 Phosphate acyltransferases SM00563 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533 SM00466 Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) SM00516 These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity SM00562 Domain in ubiquitin-specific proteases SM00695 Dysferlin domain, N-terminal region SM00693 Domain containing Gla (gamma-carboxyglutamate) residues SM00069 interferon regulatory factor SM00348 Thrombospondin N-terminal -like domains SM00210 Diacylglycerol kinase catalytic domain (presumed) SM00046 ATPases associated with a variety of cellular activities SM00382 Endothelin SM00272 Guanine nucleotide exchange factor for Ras-like GTPases SM00229 domain in DSRM or ZnF_C2H2 domain containing proteins SM00572 ankyrin repeats SM00248 associated with SET domains SM00570 Defensin/corticostatin family SM00048 Myosin. Large ATPases SM00242 G2 nidogen domain and fibulin SM00682 SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. Domain in SET domain containing proteins and in Deinococcus radiodurans DRA1533 SM00466 A domain family that is part of the cupin metalloenzyme superfamily SM00558 Small domain found in the jumonji family of transcription factors SM00545 Olfactomedin-like domains SM00284 RIIalpha, Regulatory subunit portion of type II PKA R-subunit SM00394 proline-rich domain in spliceosome associated proteins SM00581 Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc SM00683 GTPase-activator protein for Rho-like GTPases SM00324 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme SM00701 Domain in histone families 1 and 5 SM00526 tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) SM00552 ATPase domain of DNA mismatch repair MUTS family SM00534 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins SM00709 CLUSTERIN alpha chain SM00035 Insulin growth factor-binding protein homologues SM00121 Pulmonary surfactant proteins SM00019 Acidic and basic fibroblast growth factor family SM00442 Dysferlin domain, C-terminal region SM00694 Ly-6 antigen / uPA receptor -like domain SM00134 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. Involved in homodimerisation (either directly or indirectly) SM00517 Pancreatic ribonuclease SM00092 Leucine rich repeat, ribonuclease inhibitor type SM00368 Alpha-amylase domain SM00642 SAND domain SM00258 von Willebrand factor (vWF) type A domain SM00327 Leucine rich repeat N-terminal domain SM00013 Z-DNA-binding domain in adenosine deaminases. Helix-turn-helix-containing domain. Also known as Zab SM00550 Adenylyl- / guanylyl cyclase, catalytic domain SM00044 Ephrin receptor ligand binding domain SM00615 Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylat SM00454 Suppressor-of-White-APricot splicing regulator SM00648 Baculoviral inhibition of apoptosis protein repeat SM00238 The Nebulin repeat is present also in Las1. Tandem arrays of these repeats are known to bind actin SM00227 Calcium-binding EGF-like domain SM00179 Low molecular weight phosphatase family SM00226 Tetratricopeptide repeats SM00028 Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit) SM00471 Domain present in phytochromes and cGMP-specific phosphodiesterases SM00065 DNA polymerase A domain SM00482 snRNP Sm proteins SM00651 amyloid A4 SM00006 Phosphoinositide 3-kinase family, accessory domain (PIK domain) SM00145 Protein present in Fab1, YOTB, Vac1, and EEA1 SM00064 Modified RING finger domain SM00504 Immunoglobulin C-Type SM00407 Domain present in ZO-1 and Unc5-like netrin receptors SM00218 Domain found in Dishevelled, Egl-10, and Pleckstrin SM00049 G protein gamma subunit-like motifs SM00224 Domain present in Dishevelled and axin SM00021 Phosphatidylinositol phosphate kinases SM00330 Death effector domain SM00031 TAZ zinc finger, present in p300 and CBP SM00551 Possible catecholamine-binding domain present in a variety of eukaryotic proteins SM00664 Immunoglobulin V-Type SM00406 divergent subfamily of APPLE domains SM00473 C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein SM00517 Xeroderma pigmentosum G I-region SM00484 Interleukin-10 family SM00188 Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway SM00396 Kazal type serine protease inhibitors SM00280 Laminin N-terminal domain (domain VI) SM00136 Domain Homologous to E6-AP Carboxyl Terminus with SM00119 domain present in PNGases and other hypothetical proteins SM00613 CCAAT-Binding transcription Factor SM00521 AN1-like Zinc finger SM00154 Laminin G domain SM00282 Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 SM00515 Interleukin-1 homologues SM00125 DEATH domain, found in proteins involved in cell death (apoptosis) SM00005 erythroblast transformation specific domain SM00413 DNA Topoisomerase I (eukaryota) SM00435 Leucine rich repeat C-terminal domain SM00082 Pumilio-like repeats SM00025 ig-like, plexins, transcription factors SM00429 suppressors of cytokine signalling SM00253 semaphorin domain SM00630 Immunoglobulin C-2 Type SM00408 domain with conserved PWWP motif SM00293 TRAM, LAG1 and CLN8 homology domains. Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilep SM00724 catalytic domain of ctd-like phosphatases SM00577 Dual specificity phosphatase, catalytic domain SM00195 Kringle domain SM00130 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins SM00539 Complement component C1q domain SM00110 Tyrosine kinase, catalytic domain SM00219 SAM / Pointed domain SM00251 Link (Hyaluronan-binding) SM00445 Glycoprotein hormone beta chain homologues. SM00068 Histone H3 SM00428 domain in transcription and CHROMO domain helicases SM00592 DnaJ molecular chaperone homology domain SM00271 Regulator of G protein signalling domain SM00315 Histone H4 SM00417 domain present in proteins, which are involved in regulation of nuclear pre-mRNA SM00582 Methyl-CpG binding domain SM00391 Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases SM00676 Putative lipopolysaccharide-modifying enzyme SM00672 Thrombospondin N-terminal -like domains. SM00210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer) SM00283 Domains present in proteins implicated in post-mortem DNA fragmentation SM00266 Domain found in sea urchin sperm protein, enterokinase, agrin SM00200 DEATH domain, found in proteins involved in cell death (apoptosis). Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers SM00005 Domain in the RNA-binding Lupus La protein SM00715 Eukaryotic homologues of bacterial periplasmic substrate binding proteins SM00079 Forkhead associated domain SM00240 LGN motif, putative GEFs specific for G-alpha GTPases SM00390 BED zinc finger SM00614 Putative GTP-ase activating proteins for the small GTPase, ARF SM00105 Inositol polyphosphate phosphatase, catalytic domain homologues SM00128 Domain containing Gla (gamma-carboxyglutamate) residues. A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration SM00069 Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs. Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases SM00164 CLUSTERIN Beta chain SM00030 Phospholipase A2 SM00085 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has n SM00198 Aamy_C domain SM00632 PI3-kinase family, Ras-binding domain SM00144 corticotropin-releasing factor SM00039 Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fo SM00191 Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains SM00544 Interferon alpha, beta and delta SM00076 Splicing Factor Motif, present in Prp18 and Pr04 SM00500 Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted SM00233 Helicase and RNase D C-terminal SM00341 zinc finger binding to DNA consensus sequence [AT]GATA[AG] SM00401 LamG-like jellyroll fold domain SM00560 domain involved in Ras-like GTPase signaling SM00593 meprin and TRAF homology SM00061 Caspase, interleukin-1 beta converting enzyme (ICE) homologues SM00115 ParB-like nuclease domain SM00470 Found in Skp1 protein family SM00512 domain in TBC and LysM domain containing proteins SM00584 bromo domain SM00297 A Receptor for Ubiquitination Targets SM00256 Contains conserved Gly-Tyr-Phe residues SM00444 Homologues of snake disintegrins SM00050 domain in different transcription and chromosome remodeling factors SM00571 VPS10 domain SM00602 C-terminal cystine knot-like domain (CTCK) SM00041 Transferrin SM00094 Cystatin-like domain SM00043 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains SM00198 Somatomedin B -like domains SM00201 Rhodanese Homology Domain SM00450 B-Box C-terminal domain SM00502 Transglutaminase/protease-like homologues SM00460 Basic domain in HLH proteins of MYOD family SM00520 Leucine-rich repeat - CC (cysteine-containing) subfamily SM00367 Toll - interleukin 1 - resistance SM00255