ID   D0VTW9_9INFA            Unreviewed;       470 AA.
AC   D0VTW9;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   08-MAR-2011, entry version 8.
DE   SubName: Full=Neuraminidase;
GN   Name=NA;
OS   Influenza A virus (A/Esfahan/708/2008(H1N1)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=684568;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/Esfahan/708/2008;
RA   Shafiei Jandaghi N.Z., Mokhtari Azad T.;
RT   "Molecular characterization and phylogenetic analysis of Iranian
RT   seasonal H1N1 influenza viruses from 2005 to 2009 and pandemic H1N1
RT   compared with their corresponding vaccine strains.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-,
CC       alpha-(2->8)- glycosidic linkages of terminal sialic acid residues
CC       in oligosaccharides, glycoproteins, glycolipids, colominic acid
CC       and synthetic substrates.
CC   -!- SUBUNIT: Homotetramer (By similarity).
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DR   EMBL; GU112240; ACY01449.1; -; Viral_cRNA.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   InterPro; IPR001860; Glyco_hydro_34.
DR   InterPro; IPR011040; Neuraminidase.
DR   Gene3D; G3DSA:2.120.10.10; Neuraminidase; 1.
DR   Pfam; PF00064; Neur; 1.
DR   SUPFAM; SSF50939; Sialidase; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Host cell membrane; Host membrane; Hydrolase; Membrane;
KW   Transmembrane; Transmembrane helix; Virion.
SQ   SEQUENCE   470 AA;  51702 MW;  A0DE4674A26046FD CRC64;
     MNPNQKIITI GSISIAIGII SLMLQIGNII SIWASHSIQT GSQNNTGICN QRIITYENST
     WVNHTYVNIN NTNVVAGEDK TSVTLAGNSS LCSISGWAIY TKDNSIRIGS KGDVFVIREP
     FISCSHLECR TFFLTQGALL NDKHSNGTVK DRSPYRALMS CPLGEAPSPY NSKFESVAWS
     ASACHDGMGW LTIGISGPDN GAVAVLKYNG IITGTIKSWK KQILRTQESE CVCMNGSCFT
     IMTDGPSNKA ASYKIFKIEK GKVTKSIELN APNFHYEECS CYPDTGIVMC VCRDNWHGSN
     RPWVSFNQNL DYQIGYICSG VFGDNPRPED GEGSCNPVTV DGANGVKGFS YKYDNGVWIG
     RTKSNRLRKG FEMIWDPNGW TNTDSDFSVK QDVVAITDWS GYSGSFVQHP ELTGLDCIRP
     CFWVELVRGL PRENTTIWTS GSSISFCGVN SDTANWSWPD GAELPFIIDK
//