LOCUS NZ_ABVG02000011 14818 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum JW20 ctg273, whole genome shotgun sequence. ACCESSION NZ_ABVG02000011 NZ_ABVG00000000 VERSION NZ_ABVG02000011.1 GI:281419570 KEYWORDS WGS. SOURCE Clostridium thermocellum JW20 ORGANISM Clostridium thermocellum JW20 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ABVG02000011. FEATURES Location/Qualifiers source 1..14818 /organism="Clostridium thermocellum JW20" /mol_type="genomic DNA" /strain="JW20" /isolation_source="cotton bale" /db_xref="taxon:492476" /country="USA: Louisiana" gene complement(70..348) /locus_tag="Cther_0064" CDS complement(70..348) /locus_tag="Cther_0064" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250581.1" /db_xref="GI:281419571" /translation="MNDILKQIDNVLHDLGFEVVEINGNKLYHNKNKGSYYRFTFIEA FRAYVIESASNYEEAKNNLFEDGDLFSIDVDEKDFVEKLRADLIKYYC" gene complement(362..2035) /locus_tag="Cther_0065" CDS complement(362..2035) /locus_tag="Cther_0065" /inference="protein motif:SMART:SM00306" /note="SMART: Hedgehog/intein hint domain protein; KEGG: ate:Athe_2567 Hedgehog/intein hint domain protein" /codon_start=1 /transl_table=11 /product="Hedgehog/intein hint domain protein" /protein_id="ZP_06250582.1" /db_xref="GI:281419572" /db_xref="InterPro:IPR003587" /db_xref="InterPro:IPR006141" /translation="MATITLYAGKINQMPGLINEVKKSVVDYKSELSALRKKTLNINR SVCNLDEVISFIQASSQTQDRKIDSLEKFCSESEKFISEVVRIDEEVAELINKRKENF YKEYYYLKPESEKSGWEKIKDGLKSVAEWCKENWKSIAKIVAAAVVITGLGIAAALTG GILGVILAGAFWGALAGGLIGGAVGGIAAAINGGSFLEGFADGALSGAISGAVTGAAC AGLGALGALAGKSIQCMSTVGKAINVTSKVTAALSFGMDGFDMLAMGISLFDPSNALV EFNRKLHSNALYNGFQIAVNALAVFSAGAASTMKCFVAGTMILTVAGLVAIENIKAGD KVIATNPETFEVAEKTVLETYVRETTELLHLTINGEVIKTTFEHPFYVKDVGFVEAGK LQVGDKLVDSRGNVLVVEEKKLEITDKPVKVYNFKVDNFHTYHVGENRVLVHNANKYV KGTSSTLKNLDSLDDFINDPSKLKNLTPDELYNYLKNNGYNPQPLSDGSLKGILFEDG GGFKVNWGGDKLLQYHPAGSGHHGGNAYWKLSSGSTGTIRYDMNGNILK" misc_feature complement(701..1105) /locus_tag="Cther_0065" /note="Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081" /db_xref="CDD:73181" misc_feature complement(order(701..706,902..904,1103..1105)) /locus_tag="Cther_0065" /note="protein-splicing catalytic site; other site" /db_xref="CDD:73181" misc_feature complement(order(902..904,911..913,1103..1105)) /locus_tag="Cther_0065" /note="thioester formation/cholesterol transfer; other site" /db_xref="CDD:73181" misc_feature complement(698..1087) /locus_tag="Cther_0065" /note="Protein of unknown function (DUF1557); Region: DUF1557; pfam07591" /db_xref="CDD:148935" gene complement(2233..2387) /locus_tag="Cther_0066" /pseudo gene complement(2483..3289) /locus_tag="Cther_0067" CDS complement(2483..3289) /locus_tag="Cther_0067" /inference="protein motif:PFAM:PF09250" /note="PFAM: Bifunctional DNA primase/polymerase ; Primase 1; KEGG: ate:Athe_0745 bifunctional DNA primase/polymerase" /codon_start=1 /transl_table=11 /product="Bifunctional DNA primase/polymerase" /protein_id="ZP_06250583.1" /db_xref="GI:281419573" /db_xref="InterPro:IPR014820" /db_xref="InterPro:IPR015330" /translation="MKMTMMDAALKYAETNIPVIPLHWICEDGSCSCKKGQQCDSKGK HPLYTGWYKNSTTDVEQIKKWWTKTPNANIGIPTGAKSDWLVLDVDDGGDETLSALES THGKLPDTVTAVTGRGGRHYIFKYPQGRSIPNKTKFAPGLDTRSTGGLIVVAPSIHVS GNRYEWIKDYSPFDRTPAEAPAWLLKLMERVEVLLTPFEGSSIIAEIKEGSRNSTLTS LAGSMRARGMTEEGIYTALLAENNARSNPPLDEAEIKKIYSLGFQRVSSL" misc_feature complement(2729..3175) /locus_tag="Cther_0067" /note="Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859" /db_xref="CDD:80309" misc_feature complement(order(2861..2863,2927..2929,3023..3025, 3029..3031,3158..3160)) /locus_tag="Cther_0067" /note="polymerase nucleotide-binding site; other site" /db_xref="CDD:80309" misc_feature complement(order(2822..2824,2840..2842,3143..3145, 3155..3157)) /locus_tag="Cther_0067" /note="DNA-binding residues; DNA binding site" /db_xref="CDD:80309" misc_feature complement(order(2840..2842,2861..2863,2927..2929, 2933..2938,2945..2947,3023..3025,3029..3031,3065..3067)) /locus_tag="Cther_0067" /note="nucleotide binding site; other site" /db_xref="CDD:80309" misc_feature complement(order(2861..2863,2927..2929,3023..3025, 3029..3031)) /locus_tag="Cther_0067" /note="primase nucleotide-binding site; other site" /db_xref="CDD:80309" misc_feature complement(2492..2683) /locus_tag="Cther_0067" /note="Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708" /db_xref="CDD:149687" gene complement(3416..3553) /locus_tag="Cther_0068" CDS complement(3416..3553) /locus_tag="Cther_0068" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: cbb:CLD_2459 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250584.1" /db_xref="GI:281419574" /translation="MSKKKYIVRCPRCNHRVFDADYADIEIKCPVCKKVFEVKLEKKA G" gene complement(3554..3934) /locus_tag="Cther_0069" CDS complement(3554..3934) /locus_tag="Cther_0069" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250585.1" /db_xref="GI:281419575" /translation="MSTEKDSMLRVRLTKRQSDELDAIIDELQAQMPEASVTTSSIAR YALEKYVSDHIAKRDGTKIFIEISTADATEEDIKNLYDLLSKLFDETKENYSPMVHYM VGEILEPVMMKMASLMKPKKPEVK" gene complement(4123..4503) /locus_tag="Cther_0070" CDS complement(4123..4503) /locus_tag="Cther_0070" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250586.1" /db_xref="GI:281419576" /translation="MQNDMIISTGDKELTIKYLYTVEDYFTFNIRVKSGEFSGVSNFC ISKKMIYSIVERLTEMHKELKGSCEIVDNDSDAYITLSMDKHGHMSINGQIGGSHEEH LLKFKYSTDQTVLERVIKLFEELL" gene complement(4526..4723) /locus_tag="Cther_0071" CDS complement(4526..4723) /locus_tag="Cther_0071" /inference="similar to AA sequence:KEGG:lp_0374" /note="KEGG: lpl:lp_0374 extracellular protein" /codon_start=1 /transl_table=11 /product="extracellular protein" /protein_id="ZP_06250587.1" /db_xref="GI:281419577" /translation="MKEVMSNPLENATKVPLKNGMTDPRWLGTDGWVKMQRVIPTSDG NITIHFNYNEITGVFDDFKFK" mobile_element complement(4798..6167) /mobile_element_type="insertion sequence:ISCth14 element like, family IS110" gene complement(4892..6139) /locus_tag="Cther_0072" CDS complement(4892..6139) /locus_tag="Cther_0072" /inference="protein motif:PFAM:PF02371" /note="PFAM: transposase IS116/IS110/IS902 family protein; transposase IS111A/IS1328/IS1533; KEGG: bcx:BCA_2283 transposase, IS110 family, OrfB" /codon_start=1 /transl_table=11 /product="transposase IS110 family protein" /protein_id="ZP_06250588.1" /db_xref="GI:281419578" /db_xref="InterPro:IPR002525" /db_xref="InterPro:IPR003346" /translation="MRSGDKEKERIHIYNKRNICFVGVDMHKEKHCAVVIDCWMEKIG EVNFENRPSKFPAFVEDIRKICGTRDFVFGLEDTRGFGRNLASYLTGRKFEVKHVNPA YTSAVRLSNPIVYKDDSYDAYCVARVLRDMVDTLQDAKHEDVYWAIRQLVKRRDMIVK NNVMNKNQLHSQLSYSYPSYKKLFAQVDGKSALCFWENYPSPEHIWSTTSEKIYETIK PVHQALKIERIHAIIDMIKKDGNTQKGYQEERDSIVRNIVKDIKNNQELIKDIEEQLR KLLPQTGYKLQTMPGIDLITESKIVSEIGDINRFPDSDKLARFMGLAPVHFSSAGKGK DERCRNGNRELNAIFHFLAIQMVAISPSGKPRHPVFREYFEQKVKESKNKPQALICIA RRLVRIIYGMMKTKTEYRPYEKS" misc_feature complement(5585..5875) /locus_tag="Cther_0072" /note="Transposase; Region: Transposase_9; pfam01548" /db_xref="CDD:144952" misc_feature complement(5015..5284) /locus_tag="Cther_0072" /note="Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371" /db_xref="CDD:145490" gene complement(6561..7112) /locus_tag="Cther_0073" CDS complement(6561..7112) /locus_tag="Cther_0073" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: mmz:MmarC7_1490 resolvase domain-containing protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250589.1" /db_xref="GI:281419579" /db_xref="InterPro:IPR006119" /translation="MVYAYFIENTGGEFKDNSCLFRYIKEQNISADNIYIDTADNKDE LDALLEKIEPGDTIVLRTITDLAEKRRELLHLLKELQDFGILIHSIMEPFFNGLEYFD RFQGSIEISKYYAEKKRRLAFEEARKQGVVGRPKIPEKQIETALKLYKSRLFTTEEIT KLSGVSSSTLYRALKEQGCLIRK" misc_feature complement(6720..7055) /locus_tag="Cther_0073" /note="Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788" /db_xref="CDD:155104" misc_feature complement(6591..6716) /locus_tag="Cther_0073" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116" /db_xref="CDD:186341" misc_feature complement(order(6594..6602,6606..6611,6708..6713)) /locus_tag="Cther_0073" /note="DNA-binding interface; DNA binding site" /db_xref="CDD:119388" gene complement(7380..7730) /locus_tag="Cther_0074" CDS complement(7380..7730) /locus_tag="Cther_0074" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250590.1" /db_xref="GI:281419580" /translation="MSKDIRTVRPPVQLLPKAIIAVRPASTAKADLEVMAAQVAQLTT VCCQENIQVDSIIITFGGIKDITKRVKQLTEQKDISYLIIYSGKQIAENESEYVNFKR DMQDWYNLKVVCYR" mobile_element 7876..9322 /mobile_element_type="insertion sequence:IS120 element like" gene 7934..8227 /locus_tag="Cther_0075" CDS 7934..8227 /locus_tag="Cther_0075" /inference="protein motif:PFAM:PF01527" /note="PFAM: transposase IS3/IS911 family protein; KEGG: cce:Ccel_1666 transposase IS3/IS911 family protein" /codon_start=1 /transl_table=11 /product="transposase IS120 family protein" /protein_id="ZP_06250591.1" /db_xref="GI:281419581" /db_xref="InterPro:IPR002514" /db_xref="InterPro:IPR009057" /translation="MEKRKHFTPEQKAKIVIEVIKGERTLNEIAAEYGIHPNLLSRWK TEFISNAGRVFSKETDEVEKVKQSYEKEKDELLKQIGQLSYEVAWLKKKSGLL" misc_feature 7934..>8074 /locus_tag="Cther_0075" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116" /db_xref="CDD:186341" gene 8244..9086 /locus_tag="Cther_0076" CDS 8244..9086 /locus_tag="Cther_0076" /inference="protein motif:PFAM:PF00665" /note="PFAM: Integrase catalytic region; KEGG: cce:Ccel_2702 transposase IS3/IS911 family protein" /codon_start=1 /transl_table=11 /product="Integrase catalytic region" /protein_id="ZP_06250592.1" /db_xref="GI:281419582" /db_xref="InterPro:IPR001584" /db_xref="InterPro:IPR012337" /translation="MKMIDRNEKKLSITRQAELLSLNRTSVYYKPAPVNEEEYLIKRI IDEIYASYPEYGYRRMTSILNKDYHIHINRKRTRRYMREMGIHGFCPGPNLSKRIHGK NLYPYLLRNLKIDHPNQVWSIDVTYCRMKRGFMYMVAIIDWYSRYIVGFELSNTLDKT FVIEAIQKAIKRYGKPEIMNSDQGSQFTSDDYINLLKNNGIKISMDGKGRALDNQRIE RFFRSYKWEKLYLEECETVQQLRQITKEYVEHYNHRRPHQSLDYKTPAEYYFGGYDQL LAVV" misc_feature 8337..9044 /locus_tag="Cther_0076" /note="putative transposase OrfB; Reviewed; Region: PHA02517" /db_xref="CDD:177368" misc_feature 8586..8918 /locus_tag="Cther_0076" /note="Integrase core domain; Region: rve; cl01316" /db_xref="CDD:154329" mobile_element complement(9616..11008) /mobile_element_type="insertion sequence:ISCth5 element like, family IS256" gene complement(9670..10890) /locus_tag="Cther_0077" CDS complement(9670..10890) /locus_tag="Cther_0077" /inference="protein motif:PFAM:PF00872" /note="PFAM: transposase mutator type; KEGG: aac:Aaci_3132 transposase mutator type" /codon_start=1 /transl_table=11 /product="transposase mutator type" /protein_id="ZP_06250593.1" /db_xref="GI:281419583" /db_xref="InterPro:IPR001207" /translation="MATNNRMALLEQLSKYVVEKDKDFLKEALTLLINALMDAEVTSI IGAEKYERNNNRNNYRNGYRLREWDTRVGTLQLSIPKLRHGSYFPSLLEPRKMSEKAL LNVVQEAYVHGVSTRKVDELVEALGMKGIDKSEVSRISKQLDEFVEEFKNRRLEGEYP YLWLDATFPKVREGGRVCSMALVIAVGVNQQGEREILGFDVGMSEDGAFWEEFLRRLV ARGLKGVRLVISDAHEGLKAAIKKILTGSAWQRCRVHFMRNVLSQVPKHYQGMVSSII RTIFAQNDQESAREQLRHVVDELKNRFPKAMKILEEAEEEILAYMAFPREHWAQIHST NPLERLNREIRRRTDVVCIFPNREAVIRLVGAMLMEQNDEWKVGRRYFSLESMSKITS INEFTLTPVALLHK" misc_feature complement(9757..10824) /locus_tag="Cther_0077" /note="Transposase, Mutator family; Region: Transposase_mut; pfam00872" /db_xref="CDD:109910" misc_feature complement(10108..10395) /locus_tag="Cther_0077" /note="MULE transposase domain; Region: MULE; pfam10551" /db_xref="CDD:151094" gene complement(11518..11889) /locus_tag="Cther_0078" CDS complement(11518..11889) /locus_tag="Cther_0078" /inference="similar to AA sequence:KEGG:Cbei_3223" /note="KEGG: cbe:Cbei_3223 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_06250594.1" /db_xref="GI:281419584" /translation="MREYDNLYCKIYVDSDLDIEQLKQKIISIVSGEKQLFRTIVTTF GEIDINKNEDFDDEKRKLEVDGFIYSRYYLDIEPKEDIGQQEYISHIGNLLRSLWSSG LKSVAACDFEEELPQKGGYSR" gene complement(11902..13704) /locus_tag="Cther_0079" CDS complement(11902..13704) /locus_tag="Cther_0079" /inference="protein motif:PFAM:PF00756" /note="PFAM: putative esterase; SMART: Hedgehog/intein hint domain protein; KEGG: cce:Ccel_1232 carbohydrate binding family 6" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="ZP_06250595.1" /db_xref="GI:281419585" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR003587" /db_xref="InterPro:IPR006141" /translation="MSRKLFSVLLVGLMLMTSLLVTISSTSAASLPTMPPSGYDQVRN GVPRGQVVNISYFSTATNSTRPARVYLPPGYSKDKKYSVLYLLHGIGGSENDWFEGGG RANVIADNLIAEGKIKPLIIVTPNTNAAGPGIADGYENFTKDLLNSLIPYIESNYSVY TDREHRAIAGLSMGGGQSFNIGLTNLDKFAYIGPISAAPNTYPNERLFPDGGKAAREK LKLLFIASGAVTGAACAGLGALGAAAGKSIQCMSTVGKAINVTSKVTAALSFGMDGFD MLAMGISLFDPSNALVEFNRKLHSSALHNGFQIAVNALAVFSAGAASTMKCFVAGTMI LTVAGLVAIENIKAGDKVIATNPETFEVAEKTVLETYVRDTTELLHLAINGEVIKTTF EHPFYVKDVGFVEAGKLQVGDKLVDSRGNVLVLEGKKLEITDKPVKVYNFKVDNFHTY HVGENRVLVHNANKYVKGTRNIPQGLTSEQFSNASKLIRQKVGDISDDIVVQGSRAGG TAKATSDIDFAIRVSPEQFDDLVKQKFGTPNVGSAKERTMLNAIKTGKIQSGEAGLRG LRKQLQEMLGIDVDISIIKSGGPFDSGPTIELPK" misc_feature complement(<13033..13566) /locus_tag="Cther_0079" /note="Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031" /db_xref="CDD:187168" misc_feature complement(12322..12726) /locus_tag="Cther_0079" /note="Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081" /db_xref="CDD:73181" misc_feature complement(order(12322..12327,12523..12525,12724..12726)) /locus_tag="Cther_0079" /note="protein-splicing catalytic site; other site" /db_xref="CDD:73181" misc_feature complement(order(12523..12525,12532..12534,12724..12726)) /locus_tag="Cther_0079" /note="thioester formation/cholesterol transfer; other site" /db_xref="CDD:73181" misc_feature complement(12319..12708) /locus_tag="Cther_0079" /note="Protein of unknown function (DUF1557); Region: DUF1557; pfam07591" /db_xref="CDD:148935" misc_feature complement(<12130..12249) /locus_tag="Cther_0079" /note="Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403" /db_xref="CDD:143393" misc_feature complement(order(12154..12156,12160..12165,12184..12186, 12193..12201)) /locus_tag="Cther_0079" /note="NTP binding site; other site" /db_xref="CDD:143393" misc_feature complement(order(12154..12156,12160..12165,12184..12186, 12193..12201)) /locus_tag="Cther_0079" /note="active site" /db_xref="CDD:143393" misc_feature complement(order(12154..12156,12160..12162)) /locus_tag="Cther_0079" /note="metal binding triad; metal-binding site" /db_xref="CDD:143393" gene 14064..14216 /locus_tag="Cther_0080" /pseudo gene complement(14299..>14818) /locus_tag="Cther_0081" /pseudo ORIGIN 1 gctttacgat tcaggtaagt gaagctactt catgttaaat ctgtctaaac ataaacaatg 61 atcaaccttt taacaataat attttattaa atcagctcta agtttctcaa caaaatcctt 121 ctcatccaca tctattgaaa acaggtcacc atcttcaaat agattatttt tagcctcttc 181 atagttacta gcagattcaa taacataagc tctaaaagcc tctataaaag taaatctata 241 atagcttcct ttgtttttat tatgatacaa tttattaccg ttaatctcca caacctcgaa 301 tcctagatca tgtaaaacat tatcaatttg tttcaaaata tcattcataa ccccaccttc 361 tttacttaag tatgttgcca ttcatatcat aacgtattgt ccctgttgaa cctgatgata 421 atttccaata tgcatttcca ccatggtgac ctgaacctgc tggatgatac tgcaggagtt 481 tgtctccacc ccaattgacc ttaaatcctc caccatcttc aaaaagtatt ccttttaaag 541 agccatcact tagcggctga gggttatatc cgttgttttt taaataatta tataactcgt 601 caggagttaa attctttagt ttactcgggt cattaataaa atcatctaag ctatcaaggt 661 tttttagagt actactcgtt cccttaacat acttattcgc attatgaacc aataccctat 721 tttcgccaac atgatacgta tgaaaattat cgaccttaaa attgtaaacc tttacaggct 781 tatctgttat ttcaagcttt ttctcttcca ccaccaaaac attgcctctt gaatcaacca 841 acttatctcc tacttgcagt tttcccgctt caacaaaacc cacatcttta acataaaacg 901 gatgctcaaa ggttgtcttg attacctctc cattgattgt caaatgcaaa agctccgttg 961 tttctctcac atatgtctca agcaccgtct tttccgctac ttcaaaagtc tccggattcg 1021 tcgcaattac cttgtcccct gccttgatat tctctatcgc aaccaagcct gccacagtca 1081 atatcattgt acctgcaaca aagcacttca ttgtcgatgc cgccccggca ctgaaaacag 1141 ccagcgcgtt tacagcaatc tggaatccgt tataaagtgc attggaatgc agcttccggt 1201 taaattcaac caatgcattg gatggatcaa acaatgatat tcccattgcc agcatgtcaa 1261 atccatccat accaaaagaa agtgctgccg taacctttga cgtaacattt atcgcttttc 1321 ccactgtgct catacattgg atgcttttcc ctgctagagc tcctaaagca ccaagcccgg 1381 cacatgccgc tcctgtcacc gctccggaaa ttgctccgct taaagcgccg tccgcaaatc 1441 cttccagaaa cgatcctcca tttatcgccg cggctattcc tccaaccgct ccccctatca 1501 atcctccggc caatgctccc cagaatgctc ctgccagtat gactcccaat ataccgcctg 1561 tcaatgccgc cgctatcccc aacccggtaa taactactgc ggcagccact atcttggcaa 1621 tggatttcca attctcttta caccactccg caaccgactt taagccgtcc ttgatttttt 1681 cccagccgct tttctcgctt tccggtttta aataataata ttctttgtaa aaattttctt 1741 tccgtttatt gataagctca gccacttctt catcgatacg tactacttcc gatataaact 1801 tctcgctttc actgcagaat ttctcaagtg aatcaatttt tctatcctga gtctgggaag 1861 atgcctgtat gaaacttatt acttcatcca aattgcatac acttctgttg atgttcaaag 1921 ttttctttct caatgcggat aattctgact tgtaatccac cacagatttc ttgacttcat 1981 ttatcaatcc gggcatttgg ttgattttcc cggcatataa cgttatagtt gccattttat 2041 taactcaaaa ttatcatccc aatgcttgca atccgtggtt gccttataat aaattgcaat 2101 taaactaaat tggaacataa tccaaaaccc tcagtaaaaa ataatgccag gaaacttttc 2161 tgccttttcc tggcattatt atattatttc tattctgaaa aagcaagtaa aacgtaccta 2221 ttttacaaat caagccgccg ccagctcgtt ttcctcctct tcttttctcc tttttcttat 2281 attataatca tagcaacaac tattgacgtg attaatactg cagacaccgc tgcaataacc 2341 cacagccaga aaaatccaac atgtatattc cttatctcct gaaagctgaa ttgttcaggc 2401 aatacgtaaa tactttatga ctgtacaaag ctcctttgca aaaatcaagc ggctttgtgc 2461 gtatatcgta tatattaatt ctttacaagc tactaactct ttgaaaacct aaactatata 2521 ttttcttaat ttccgcttca tcaagcggag gattgctcct tgcgttgttt tctgcaagta 2581 atgccgtata gatgccttcc tccgtcattc ctcttgctct catactcccg gcaaggctcg 2641 tcagggtgct attgcggctg ccttccttaa tctctgctat aatactgcta ccttcaaagg 2701 gtgtaagcaa tacttccacc ctttccatga gctttaataa ccatgctggt gcttctgccg 2761 gggttctgtc aaagggagaa taatccttta tccattcata ccgattaccg cttacatgaa 2821 tgcttggggc tacgacaatc agtccacctg ttgaacgcgt atcaagaccc ggtgcaaact 2881 ttgttttatt aggaatgctc ctgccttgtg ggtatttgaa gatatagtgc cgacctcctc 2941 tgccggtaac agcagtaacc gtatcaggaa gttttccatg tgttgattca agagccgata 3001 gagtttcatc accgccatcg tccacatcaa gtaccagcca gtcggatttc gcacctgtag 3061 gaatgcctat attggcattg ggtgttttcg tccaccattt ctttatttgc tcaacatcag 3121 tagtggagtt cttgtaccag ccggtatata acggatgctt tcccttgctg tcgcattgtt 3181 gtcccttctt gcaggagcag gagccatcct cacaaatcca gtgcagaggt ataactggga 3241 tattggtttc tgcatatttt aatgccgcgt ccatcattgt cattttcaaa ttctcacctc 3301 ctgtcgtgct agaaaattta aagagcccga caaatagttt attaagacta tctgccaggc 3361 tctataggtg agtcattcgc tccctttgtg gctctgtgcc agatttattc actttttacc 3421 ccgccttttt ctccagcttt acttcaaaaa cctttttgca taccggacat ttgatttcaa 3481 tatcagcgta atcggcatca aatactctgt gattgcagcg tgggcaacga acaatatact 3541 ttttcttact cactcacttc acctccggct tctttggttt catgaggctt gccatcttca 3601 tcatcacagg ctctaatatc tctccaacca tgtaatgaac cattggtgag taattctctt 3661 ttgtttcgtc aaacagcttc gagagaaggt cgtagagatt ctttatgtcc tcttctgtgg 3721 catctgctgt actaatttca atgaaaatct tggtaccgtc acgcttggcg atatggtcgc 3781 tcacatactt ctccagagcg tatcttgcta tgcttgatgt ggtaacactt gcttccggca 3841 tttgcgcttg cagttcatca atgatggcat ccaattcatc cgactgcctt tttgtaagcc 3901 ttacccgaag catactatcc ttttctgtag acattattac acctcctgta tttcttgttg 3961 gtttaattgt accacaacgt attacgcttt gtcaagcata gataaaaaga aaacccgact 4021 tgccgtttta ttggcttgcc gggtacttgc tttactccgt atttttctta ttaacgaaag 4081 atatattata gcattaaaac tatttgttct actccttttt gattatagta actcttcgaa 4141 cagtttgatt accctttcca gaacagtttg gtctgtacta tatttaaatt tcaaaagatg 4201 ttcttcatgg cttccaccta tttgaccatt tattgacata tgtccgtgtt tatccatgct 4261 aagagtaata taggcatctg aatcattatc gacaatttca caagatcctt tcagttcctt 4321 atgcatttca gttaatctct caactattga ataaatcatt ttttttgata tacaaaaatt 4381 tgatacacca gaaaactccc cagattttac tctaatattg aatgtgaaat agtcttcaac 4441 tgtatacaga tactttattg tcaattcttt atctcccgta ctaataatca tatcattttg 4501 cataattata taccctccac ttaatttatt tgaatttaaa atcatcaaat acaccagtaa 4561 tttcattata attaaaatga attgttatgt taccatcgga tgttggaata acacgttgca 4621 ttttaaccca accatctgta ccaagccatc ttggatcagt cattccattt ttcaatggta 4681 cttttgtagc attttccaat ggatttgaca ttacctcttt cattgcgagt tgctcattca 4741 aattattagc aactgtacgc cctgttgatc ctcttcccag aatcttaact tcagtactac 4801 tcgttccctc actacaagaa ctatatatag tatataatcc ttgttaccat atctcaatta 4861 aaaaatcaaa atactactac ttctttttct cctatgactt ctcatacggt ctatactctg 4921 tcttggtctt catcattccg tagattatcc ttacaagcct tcttgctata catataagtg 4981 cctgtggctt gtttttactc tctttaacct tctgttcaaa atactctctg aatactggat 5041 gtcttggctt tcctgatggt gatatggcta ccatttgtat agccaaaaaa tgaaatattg 5101 cattcaactc tctgtttcca tttctgcacc gttcatcctt gcctttacct gctgaactga 5161 aatgtactgg tgccaacccc ataaatcgag ccagcttatc tgaatctggg aatctgttaa 5221 tatcaccaat ttcagataca atctttgatt ctgtaataag gtctatacct ggcatggttt 5281 gcaacttata ccccgtctgt ggcaataatt ttcttaactg ctcttctatg tcttttatta 5341 gttcctgatt gttcttaata tcctttacaa tattccttac aattgaatct ctttcttcct 5401 gatacccctt ctgtgtattt ccgtcctttt taatcatatc gataattgca tgaatacgct 5461 ctatctttaa tgcctgatgt actggtttta ttgtttcata aatcttttct gatgtagtac 5521 tccaaatatg ctctggtgaa ggatagtttt cccagaagca tagtgcactt ttgccatcaa 5581 cctgtgcaaa taatttctta taggatggat aactataaga caactgactg tgtaattggt 5641 ttttgttcat aacattgttt tttactatca tatcccgtct ttttaccaac tgccgaattg 5701 cccagtatac atcctcatgt tttgcatcct gtaatgtatc caccatatcc cttaataccc 5761 ttgcaacaca ataggcatca taggaatcat ccttgtatac aataggattt gaaagcctta 5821 ctgcactggt ataggctgga ttcacatgtt tgacttcaaa cttccttcct gtaaggtatg 5881 aagccagatt acgcccaaaa cctctggtat cctcaagtcc aaatacaaag tctcttgtac 5941 cacatatttt cctgatatcc tcaacaaatg ctggaaactt ggatggtctg ttttcaaagt 6001 tgacctctcc gattttttcc atccagcaat caattacaac tgcacaatgc ttttccttgt 6061 gcatatctac ccctacaaag catatatttc ttttattata aatatgtatc ctctcctttt 6121 ccttgtctcc actacgcaca tcggcaacct caatttaaga gcgttagctt tttacagccc 6181 gcaagggaac gacagcctat ctgttcctaa tgtgacaaat tacgtgatta tggcaccacg 6241 agcctttatt gactacactt ttttgatgat gttaccgtca ccattcacta aagtccagtc 6301 ttcttgaaaa ttttcactcg cttatatacc ataacctgtc tttatttttg ttcacatgaa 6361 aaccctaact gttagggtta tacccgattt atgtcctacc cttaattttc aactgccctt 6421 tttcccttgt cgttcaaggc ttttctgact tctgtaaatt tgaagttaat actaaaaaaa 6481 ttttttaaca ttatgcagga agagaccggg cactgcacgc ccgatctctt cctgttaatc 6541 tatatctatt aataccattc ctatttgcga attaagcacc cctgctcctt taatgctctg 6601 taaagggtac tactgcttac cccagataac tttgtaattt cctctgtggt aaatagtcta 6661 ctcttgtata gctttaatgc tgtttcaatc tgcttctctg gtatctttgg tcttcctact 6721 accccttgct ttcttgcttc ttcaaaggct aatcttcttt ttttctcagc ataatattta 6781 ctgatttcta ttgaaccttg aaatctgtcg aaatactcta aaccattaaa aaatggctcc 6841 attatactat gtatcaagat accaaagtct tgtagttcct ttagtagatg taatagctct 6901 cttctctttt ctgctaaatc tgttattgtt cttaatacta ttgtatctcc tggctcaatc 6961 ttttctaaaa gcgcatctaa ttcatcttta ttatctgctg tatcaatgta tatgttatct 7021 gctgatatat tctgttcttt tatatatcta aacaagcaac tgttatcttt gaactcaccg 7081 cctgtatttt caataaaata tgcgtatacc attattcctc tccccccttt ctcaaaacct 7141 cttacaattt gagaatgtct ataccccttg agattaaatc aatttcttat aattcttatc 7201 tactcattcc caaaattact ccttattctt ttttcttcat aaaatatctc tatatcaacc 7261 gttttgagta atagataaat cttgatgtat tttgggaatg agcttgtttt atacccgaaa 7321 cacatattta tatattcatt aaaccatttg agatatttac tttaccaaaa cctcaactat 7381 cacctgtaac aaacaacctt taaattatac cagtcctgca tatctctctt aaaatttacg 7441 tattcacttt cattttctgc aatctgctta ccactgtata tgataagata gcttatatcc 7501 ttttgctctg tgagctgttt tactcttttt gtaatatctt ttataccccc aaaagttata 7561 atgatactgt ctacttggat attctcctga caacatactg ttgttaattg cgctacctgt 7621 gctgccatta cttcaaggtc tgcttttgct gtacttgctg gtcttactgc tattatagct 7681 ttaggtaaca actgcacagg tggtcttact gttcttatat ctttactcat tattactccc 7741 cctctctttt aactgcatct gctacattag taaatgcgct cacatccaat agaatcatat 7801 cctctgatac aaatttaaac tccactacca aatagtaata tttattaagt atcctaagaa 7861 tatctatatc tgccttataa tgataccaaa aattaagaca gacaaaacag cccaaataag 7921 ttagaatgga actatggaaa agagaaaaca ttttacacct gaacaaaaag caaaaatagt 7981 gattgaggtc atcaagggag aaagaacgct gaatgagatt gctgcagaat atggaattca 8041 tccaaacctg ttaagtcgct ggaagactga attcataagc aatgcgggca gagtattcag 8101 caaggaaact gatgaagtag agaaggtcaa acagtcgtat gaaaaggaga aggacgaact 8161 gcttaagcaa attggtcaac tatcatatga ggttgcctgg cttaaaaaaa aatctggcct 8221 cctctaaatc ccgagaagac cgcatgaaaa tgattgatag aaatgagaag aaactcagca 8281 taacaaggca agcagaatta ttgagcttaa accgtacgag cgtttactac aagcctgctc 8341 cggtaaatga ggaggaatac ctgattaagc gtatcattga tgaaatttac gcgtcttatc 8401 cggaatatgg ctatcgcagg atgacaagta tattgaacaa ggattatcac attcatatca 8461 atcgaaaacg gacccggcgt tatatgaggg aaatgggcat acatggattc tgtcctggcc 8521 ccaacctcag caaacgaata catggtaaga atttgtatcc atatctgttg agaaacttga 8581 aaattgatca tcctaatcag gtatggtcca tagatgtgac ctattgccga atgaaacgcg 8641 gtttcatgta tatggttgca ataatagact ggtattctcg gtatattgtt gggtttgaac 8701 tatcaaacac tcttgataag acattcgtca tagaagcaat ccaaaaggcc ataaagcgat 8761 atggcaagcc tgaaatcatg aacagtgatc aaggctcaca gtttaccagt gatgattaca 8821 taaatctatt aaaaaataac ggtatcaaaa tatctatgga tggaaaagga agagcattag 8881 acaaccaaag gatagaacga tttttccgtt cctacaagtg ggagaaactt tatcttgaag 8941 agtgcgaaac ggtacaacaa cttagacaaa tcacaaagga atatgtggag cactataacc 9001 ataggagacc gcaccagtca ttggattaca aaacaccggc agagtattac tttggaggat 9061 atgaccagct actggcagtt gtatagaatt atggggctcc gccccaaacc ccgtcctcac 9121 cggaaggcag ccggtctgtc ataacagacc ggaaagcaaa aggatatatg tccaaaggat 9181 gtcaagggtc aagatgaact cgcttacgct cgcccttgac atcctccaac agagtgcaca 9241 gttgtaaaga ttatacaaaa ttaagaaagg agagctaact tagaaaagct aaaaaactgt 9301 cttgacaatg gggagcatta taccttatct aatgtgagcg gtaatgtcat ttttcctgtc 9361 agctgattta cccccttctt ttacttggat acttatatta cttttttctg tcacccaatt 9421 aactgttcat gttcaaagct tttcttcttt gtccaattta catttatttt tctatccatc 9481 agacatacca tcataaaaaa gatagtgcct tatgcactag cctatttact gccatattat 9541 accgtcatat taaaatactt gatactattt aaaatacttg atactatcaa acatctttta 9601 tctttgcttt ttgttgatag tgtcttgtca agtggtgtaa aatgatttct actttatcat 9661 tttttcacct catttatgta ataaagctac tggtgtcaat gtaaattcat ttatcgatgt 9721 aatctttgac attgattcca gactgaaata gcgccgccct actttccatt catcattttg 9781 ttccatgagc attgctccta ccaatcggat taccgcctca cgatttggaa atatgcaaac 9841 aacatccgtt cgacggcgaa tttcccggtt aagtctctca agaggattgg tggagtgtat 9901 ctgtgcccaa tgctcacggg gaaaagccat atatgccagg atttcttctt ctgcttcttc 9961 aagaattttc attgcttttg gaaaacgatt tttaagctca tctactacat gccttaactg 10021 ttccctcgca gattcctgat cattctgggc aaatattgtc cgtattatcg atgataccat 10081 tccctgataa tgctttggta cctggcttaa tacgtttctc ataaaatgta cacggcatct 10141 ttgccatgca cttcccgtta aaatcttctt tattgcagcc ttcagccctt catgtgcatc 10201 actgattaca agccttacac cttttagacc ccttgctacc agccttctta aaaactcctc 10261 ccaaaaagcc ccgtcttcac tcatccctac atcaaaacct aatatttccc gttcaccttg 10321 ttgattaact cctactgcta taactagtgc catactgcat accctgcctc cttcccgaac 10381 cttggggaaa gtggcatcaa gccaaaggta aggatattct ccttccagtc tacggttttt 10441 aaattcttct acaaattcat ccagttgctt actgattctt gatacttcgc ttttatcaat 10501 ccctttcatt ccaagagctt ctacaagttc atccaccttc ctggtactta ctccatgaac 10561 ataggcttcc tgaactacat tcaataatgc tttctctgac attttcctcg gttctaaaag 10621 acttggaaaa taacttccgt gacgtaactt gggaatgctt aactgtaatg ttcctactcg 10681 agtatcccat tctcttagac gatatccatt gcgatagttg tttctattat tatttctttc 10741 atacttttca gcacctatta ttgatgtaac ttccgcatcc attagggcat taatgagtaa 10801 tgttaatgct tcttttaaaa aatctttatc tttttcaaca acatacttgc taagttgttc 10861 taaaagtgcc attctattat tagtagccac ggtatgacct cctctacttt atttgttttg 10921 ttttgtttcc ctaataaagt agaaatcata tcgtggttac ttttgtcaat tagcctccac 10981 gaaatttaca ccactacttg agactataac tttttgttta tttactctga ttttctttta 11041 tttttactgt tgtctttgtt caactacttt ttaccttttt ccaccaccaa caaccttccc 11101 ctaatagatt cacatatatg catccattta tgtatatatg tgaatcttaa ctgtagaatt 11161 tgattttcaa ctcctcattt ttcattgata ttactggatt taaaaattat ataaaaattt 11221 ttgtttattt ttaattagaa atttacattg tcagtaagtt gcaaagtaat caatctgagt 11281 aagataatgc gttcttattc attcacagaa cacttacccc tgattacttt tacgattatc 11341 tgattcataa ataataatta aattaacaga tatactaaaa tattaggcac atgtcaaata 11401 ctcttagtat gttttctatc tataagaatc cctgctgtat ctgtacttat tttcttgctc 11461 catttgctta tagcaaagaa gccacacaat aaaaattgtg tgaccttcac ttactatcta 11521 cctactatat cctccttttt gagggagttc ttcttcaaaa tcacatgctg caacagattt 11581 taaaccacta ctccacagag accgaagtaa attgccaata tgagatatat actcctgttg 11641 tccaatatct tctttgggtt ctatatccaa ataatatctt gaataaataa acccatctac 11701 ttctaacttt cttttctcat catcaaaatc ttcattttta tttatatcaa tttctccaaa 11761 tgttgtaaca attgttctga aaagctgctt ctctcctgaa actatcgaaa taatcttttg 11821 ctttagctgt tcaatatcta aatcggaatc cacatatatt ttacaatata aattatcata 11881 ttctctcatg gattaccctc cctattttgg taattcaatg gttggtccac tgtcaaatgg 11941 tccaccagat tttataattg aaatatcaac atcaatacca agcatttctt gtaattgttt 12001 ccttaaacct cttaacccag cttcgccaga ttgtattttt cctgttttaa ttgcgtttaa 12061 catagttctc tcttttgcag aacctacgtt tggtgttcca aatttctgtt ttactaaatc 12121 atcaaattgt tctggcgata ctctaattgc gaagtcaata tctgatgttg cttttgccgt 12181 tccacctgct ctacttcctt gtacaacaat atcatcacta atatctccta ctttctgtct 12241 aattaatttt gatgcatttg aaaactgttc acttgttagt ccttgaggaa tgtttctcgt 12301 tcccttaaca tacttattcg cattatgaac caatacccta ttttcgccaa catgatacgt 12361 atgaaaatta tcgaccttaa aattgtaaac ctttacaggc ttatctgtta tttcaagctt 12421 tttaccttcc aatactaaaa cattacctct tgaatcaacc aacttatctc ctacttgcag 12481 ttttcccgct tcaacaaaac ccacatcttt aacataaaac ggatgctcaa aggttgtctt 12541 gattacctct ccattgattg ccaaatgcaa aagctccgtc gtatctctca catatgtctc 12601 aagcactgtc ttttccgcta cttcaaaagt ctccggattc gtcgcaatta ccttgtcccc 12661 tgccttgata ttctctatcg caaccaagcc tgccacagtc aatatcattg tacctgcaac 12721 aaagcacttc attgtagatg ccgccccggc actgaaaaca gccagcgcgt ttacagcaat 12781 ctggaatccg ttgtgaagtg cactggaatg cagctttcgg ttaaattcaa ccaatgcatt 12841 ggatggatca aacaacgata ttcccattgc cagcatgtca aatccgtcca taccaaacga 12901 gagtgctgcc gtaacctttg atgtaacatt tatcgctttt cccactgtgc tcatacattg 12961 gatgcttttc cctgcagctg ctcccaaagc accaagcccg gcacatgccg ctcctgtcac 13021 cgctccggaa gcaataaaga gcagtttcaa tttctccctt gcagcttttc ctccgtcagg 13081 aaaaagcctc tcatttggat aagtgtttgg agccgctgaa atcgggccaa tataggcaaa 13141 tttatcgaga ttggtcaatc caatattaaa cgattgtcct ccacccattg aaagtcctgc 13201 aatcgcccga tgttcgcggt cggtgtagac tgaatagtta gattcgatat agggaataag 13261 actgttgagc aaatcttttg tgaaattttc ataaccgtcc gctattcccg gaccggcggc 13321 gttagtattc ggtgttacaa ttatcagggg cttgattttt ccctcggcaa tcagattgtc 13381 ggcaataaca ttggctctgc ctcccccttc gaaccagtcg ttttcactac cgcctatgcc 13441 gtgtaagaga tacaaaacac tgtatttttt gtcctttgaa tatcccggcg gcaaataaac 13501 tcttgccggc ctggtactgt tggtggccgt ggagaaataa gaaatattta cgacctgccc 13561 tctcggaacg ccgttcctta cctggtcata tcccgaaggc ggcatggttg gcaaggatgc 13621 cgctgatgta ctgcttattg tgacaagcaa cgatgtcata agcatcaagc caacaagtaa 13681 tacactgaaa agttttcttg acatgtttct cctccttttt gatttatgat ataaaataaa 13741 aattaatgga cctcatgtag caaacacttt tctttttgca gaattaatac ccttatttat 13801 atatttattg tttcgtgaac gctcacattt ttgtgtcggt cggccggcat catatacata 13861 tttttttctg cttgatacaa ataaacaact atgttaattt gtcgatgtta aattttgttc 13921 ttttgcctaa agcaggagta aataataaaa aaattattat gtgggagttg atttacttga 13981 gcatgcaaga tataatctcc gcaatcaaaa gaatccaaaa cggaaattta tatagtaatc 14041 aacagcaaga agccaatacc aacaattatt tgtatgtcgg accaaatatt ttgcgcgatg 14101 agtttaaatg tcttggacat aattttgaag tatttttaga ccagcttctc atgacacaag 14161 gacaaaattt ttggaattgg tatcgtacag acaaatacta tgatttttca aggtaaaaat 14221 ctatctatta tactttcacc aatagtttgg acggttccct gtttgatatc aaacaaagaa 14281 ccgtcctctg ttaatttctt aattcctgat taggtaatcg aaagcgctga gtgcggccgt 14341 cgcaccggaa cccatggcta taacaatctg tttatagggg ctgttggtac agtcacctgc 14401 tgcaaatacc ccgggcattg aggtttcatt tttttcattg acaataattt cacccatggc 14461 attgcgttca atggttcctt ccagccattc ggtatttggg acaaggccaa tctgaacaaa 14521 cactccctga acctcaatgt gcttttcttg attagtgtca cgctcaatgt aagtaatccc 14581 gtcgagcttt tccttcccgg taaactcttt tgtctggaca tttgtaagca cagttacatt 14641 gggaagcctg tacaaacgtt cctgaagcac tttgtcagct ttcagctgcg gcagaaattc 14701 cagtaccgtt acgtgtctta caatgcccgc caaatcaatg gcagcttcta taccggaatt 14761 gcctccgcca attacggcca catccttccc tgcaaacagc ggtccgtcgc agtggggg //