LOCUS NZ_ACVX01000017 73377 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00019, whole genome shotgun sequence. ACCESSION NZ_ACVX01000017 NZ_ACVX00000000 VERSION NZ_ACVX01000017.1 GI:256004686 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 73377) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 73377) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000017. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..73377 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene 118..501 /locus_tag="ClothDRAFT_1524" CDS 118..501 /locus_tag="ClothDRAFT_1524" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429663.1" /db_xref="GI:256004687" /translation="MSVTISYDLANFIMYTLGAVLIIVAVITLLNVNRFVKRLDKLVE KNEENFNKTANTIPEIAKNVNEVTIGVKQNVDKVGEAIDAVEDSVCDSILNLLEGTEG LFDFISIVGEVIKALLKRITLGKGK" gene complement(572..778) /locus_tag="ClothDRAFT_1525" CDS complement(572..778) /locus_tag="ClothDRAFT_1525" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: predicted protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429664.1" /db_xref="GI:256004688" /translation="MADKILTCKDCNAEFVFSEGEQAFYLEKGFQNEPQRCPACRQAR KQQRRNNGFSGSNRGFGRNSGDRW" gene 1063..1578 /locus_tag="ClothDRAFT_1526" CDS 1063..1578 /locus_tag="ClothDRAFT_1526" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429665.1" /db_xref="GI:256004689" /translation="MDNGKKAVLPYNRVKAVEYAHKWAFGRNPKYFNFDKLGGDCTNF ASQVLFAGSNVMNYTPVYGWYYIDANRRSPSWTGVNYLYNFLVNNKGPGPYAEETDVK DIQPGDIIQLSFGGAPHFDHSPVVVQVGSPASLRNILVAAHTYDRDYYPLTNYNWVNI RFIHILGVRTQ" gene complement(1630..2250) /locus_tag="ClothDRAFT_1527" CDS complement(1630..2250) /locus_tag="ClothDRAFT_1527" /inference="protein motif:PFAM:PF01584" /note="PFAM: CheW domain protein; SMART: CheW domain protein; KEGG: dds:Ddes_2175 CheW protein" /codon_start=1 /transl_table=11 /product="CheW protein" /protein_id="ZP_05429666.1" /db_xref="GI:256004690" /db_xref="InterPro:IPR002545" /translation="MSFKAQRAWFFVQYRQNCPLLHLIIASKVDIILLRSDYSRPVYF ACSVKFHTKQDHHEGNDVTVSQQYVIFKLNDKYFGVNIAHVMEIIWPQKVFKVPDTPP YVEGLINVRGKVFALLNLKEKFRLPDTKVMDEEAKMIIVMINSKTLAFMVDVVEEIIS IEDEEIVAVSDSSLSHCKKHLKGTAKFGDRSILLIDFEPILNETQK" misc_feature complement(1642..2058) /locus_tag="ClothDRAFT_1527" /note="CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256" /db_xref="CDD:185867" gene complement(2336..3541) /locus_tag="ClothDRAFT_1528" CDS complement(2336..3541) /locus_tag="ClothDRAFT_1528" /EC_number="2.3.1.1" /inference="protein motif:TFAM:TIGR00120" /note="KEGG: dal:Dalk_1420 arginine biosynthesis bifunctional protein ArgJ; TIGRFAM: arginine biosynthesis bifunctional protein ArgJ; PFAM: arginine biosynthesis protein ArgJ" /codon_start=1 /transl_table=11 /product="arginine biosynthesis bifunctional protein ArgJ" /protein_id="ZP_05429667.1" /db_xref="GI:256004691" /db_xref="InterPro:IPR002813" /translation="MINIIDGGVTAPKGFKAAGVACGLKNNQKKDIAVVCSSDLAVAA GVFTKNVVKGHSLQLTMQHIKSGHARALVINSGNANACLGEQGYKDAEEMASLAAQLL NCDAKNVLVGSTGVIGMPLDMPKVRSGIKEAISKLSEEGGHDAAEAIMTTDLVLKEIA VEFEIQGQKVRMGAMAKGSGMIHPNMATMIGVITTDANISRELLDKALKDVISHTFNR VSVDGDTSVCDMVVILANGKANNENIVKEDIDYSTFKSALEYVCTHLSKMIAKDGEGA TKLIEVVAEGAKSAEDAYKAVSAIAKSPLVKTAIFGEDANWGRIITAVGYSGADFDPN LVDIYIGDLLVCKSGAALNFDEEKAKEILKEDEVRIKVDFNQGTASDRIWTCDFSYDY VKINGSYRS" misc_feature complement(2339..3508) /locus_tag="ClothDRAFT_1528" /note="Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152" /db_xref="CDD:73147" misc_feature complement(order(2372..2380,2504..2506,2558..2569, 2576..2581,2585..2596,2600..2602,2606..2611,2615..2620, 2627..2635,2867..2878,2987..2989,2999..3001,3188..3193, 3296..3298,3383..3397)) /locus_tag="ClothDRAFT_1528" /note="heterotetramer interface; other site" /db_xref="CDD:73147" misc_feature complement(order(2339..2344,2354..2356,2978..2980, 3002..3004,3011..3013,3086..3091,3197..3202)) /locus_tag="ClothDRAFT_1528" /note="active site pocket" /db_xref="CDD:73147" misc_feature complement(2978..2983) /locus_tag="ClothDRAFT_1528" /note="cleavage site" /db_xref="CDD:73147" gene 4184..6631 /locus_tag="ClothDRAFT_1529" CDS 4184..6631 /locus_tag="ClothDRAFT_1529" /EC_number="3.4.21.53" /inference="protein motif:TFAM:TIGR00763" /note="KEGG: mxa:MXAN_2017 ATP-dependent protease La; TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16 lon domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: peptidase S16 lon domain protein; AAA ATPase" /codon_start=1 /transl_table=11 /product="ATP-dependent protease La" /protein_id="ZP_05429668.1" /db_xref="GI:256004692" /db_xref="InterPro:IPR001984" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR011704" /translation="MSEAKKVIKKQVLPLLPLRGLTVFPYMILHFDVGRIKSIKALEE AMINNQLIFLVAQKDAKNDSPGPEDIYTIGTISKVKQLLKLPGDTIRVLVEGISRAEI CEFTQTEPFFMAEVEEKIYVEEDKNSKTEIEALKRRVLSTFEEYSKLNNKVSPETVLS IMNIDDPDQLADIITANLMLKVEQKQEILNEFKTKIRLQKLLETLVREIEIMQIEREI NIKVRKQIDKTQKEYYLREQLKAIQSELGDKDGVVGEVEEYKRKLVEGNFGEEVEKKV LKELDRLLKMPPGSAEGSVIRTYLDWIFDLPWNKKTEEIIDLDRAQQILDEDHYGLEK VKERIIEYLAIRKLKKDLKGPILCLAGPPGVGKTSIAKSIARALNRNYVRMSLGGVRD EAEIRGHRRTYVGAMPGRIISALKQAGSKNPLILLDEIDKMSSDFRGDPAAAMLEVLD SEQNYAFRDHYLELPFDLSDVLFITTANNLDTVPRPLLDRMEVISLSSYTEEEKVQIA MKYLFPKQIEAHGFKKSNLKIDEPAVREIINCYTREAGVRELERQIAGVCRKVARKLV SSNQKTVKITAASIEKYLGTKKYRYDMANEKDEVGVATGLAWTPVGGDTLSIEVTLME GKGSLELTGQLGDVMKESARAAMSYIRSRAEYYGIDKDFYNKYDIHIHVPEGAIPKDG PSAGITLATAMVSALTGKPVRKNVAMTGEITLRGRVLPIGGVKEKVLAAHRAGIDTII IPVENKKDLEEIPENVRKTIKFVLADNMETVLNTALVKTKPKGRQKSVSGEEKTVVPE VPPQLEELDHGTATIEQ" misc_feature 4208..6517 /locus_tag="ClothDRAFT_1529" /note="ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466" /db_xref="CDD:30814" misc_feature 4217..>4384 /locus_tag="ClothDRAFT_1529" /note="Found in ATP-dependent protease La (LON); Region: LON; cl01056" /db_xref="CDD:141077" misc_feature 5189..5665 /locus_tag="ClothDRAFT_1529" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009" /db_xref="CDD:99707" misc_feature 5264..5287 /locus_tag="ClothDRAFT_1529" /note="Walker A motif; other site" /db_xref="CDD:99707" misc_feature order(5267..5290,5465..5467,5609..5611) /locus_tag="ClothDRAFT_1529" /note="ATP binding site; other site" /db_xref="CDD:99707" misc_feature 5453..5470 /locus_tag="ClothDRAFT_1529" /note="Walker B motif; other site" /db_xref="CDD:99707" misc_feature 5651..5653 /locus_tag="ClothDRAFT_1529" /note="arginine finger; other site" /db_xref="CDD:99707" misc_feature 5903..6517 /locus_tag="ClothDRAFT_1529" /note="Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362" /db_xref="CDD:114104" gene 6944..8623 /locus_tag="ClothDRAFT_1530" CDS 6944..8623 /locus_tag="ClothDRAFT_1530" /inference="protein motif:PFAM:PF07228" /note="PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: avn:Avin_28640 cyclic di-GMP signal transduction protein" /codon_start=1 /transl_table=11 /product="protein serine/threonine phosphatase" /protein_id="ZP_05429669.1" /db_xref="GI:256004693" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR010822" /translation="MRSIIRAFLKYKEYVLLAIIAVAAGLVFGIAYFLKEQFSAVMTV ESFLAWHNILEFTSVLFSFTVFAVSYYTYEQTGNLRSVFLGSVFLAVGMVDAFHTLSY KGMPAFLIENNSSNRATIFWIIARLFTALGFFISSLIPASVKIRTKRIIFVAVPLITS ISALYLATYHPELFPPMHIEGKGLTFFKIYSEHLIIILFALSVLMFIREYNKTKNKMV LLLCVSLEITIFSEAAFVLYFSVYDIYNYLGHVYKFIAFFIIFRAIFINDIQEPYRKL SKAKEKLRNHAENLDMMIRERTRELENLNQKLMQDLKYARDIQKSVFKLRNQDWEKVR FEVKNYSSEMVSGDFCNVFKIDNDNIGFYIGDVSGHGVPAAMLTIFLNQTVKTLLEME TNELNKISPAMVLENIYRSFNSTNFDENVYIVMIYAVYNRHTQVLTYSSAGLNVSPIL IKPSGEILEIEIKGFPICKFIEFYDGEYQNHALKLNKDEKILFYTDGLIEAQNTDRNF FGDMRLKEILQENYNKSASELSKLISDGIFGFTGKKEIKDDITFLIMEVVE" sig_peptide 6944..7033 /locus_tag="ClothDRAFT_1530" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.823) with cleavage site probability 0.680 at residue 30" misc_feature <7769..>7912 /locus_tag="ClothDRAFT_1530" /note="TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956" /db_xref="CDD:163083" misc_feature 7958..8548 /locus_tag="ClothDRAFT_1530" /note="Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331" /db_xref="CDD:128626" misc_feature 8009..8614 /locus_tag="ClothDRAFT_1530" /note="Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120" /db_xref="CDD:185796" gene complement(8639..9184) /locus_tag="ClothDRAFT_1531" CDS complement(8639..9184) /locus_tag="ClothDRAFT_1531" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429670.1" /db_xref="GI:256004694" /translation="MPSKKIVPNKFEQFLKNRESLIEQYAKGDLTKEEFIEANYRCIN SLDIKPFQKIDNVKKAIYNYQYYNVLAKYYQKKAHDLSRNHEARSDFLEQSNYYYSKK DEVTAKLLRLLDFKGIEAYFVKVKSKNLRKKLFEIVLLDYDNIILHSKSEAILNMLMK ENVFINEVRNSLVDSYINQKY" gene complement(9522..10154) /locus_tag="ClothDRAFT_1532" CDS complement(9522..10154) /locus_tag="ClothDRAFT_1532" /inference="protein motif:PFAM:PF05389" /note="PFAM: Negative regulator of genetic competence" /codon_start=1 /transl_table=11 /product="Negative regulator of genetic competence" /protein_id="ZP_05429671.1" /db_xref="GI:256004695" /db_xref="InterPro:IPR008681" /translation="MKIEKINENKIKVTISIDDLLERNIDLDTLNYNTPAAQELFWDM MEQAEIQFGFDASDSQICVEAIPDPEEGFVIIITKLDEDGEFESIHKYIKNRFRKSDL RVRKRNSRVSSSIVIYFFNNFEDLCSVCQKLRDIYSGESTLYRLKGVYYLVLTKNSWS VANLRSFEPILSEFGTKVSNVSFYEGYLNEHGEKIIEYNAVETINDYFHR" misc_feature complement(9540..10118) /locus_tag="ClothDRAFT_1532" /note="Negative regulator of genetic competence (MecA); Region: MecA; cl02022" /db_xref="CDD:186507" gene 10535..11419 /locus_tag="ClothDRAFT_1533" CDS 10535..11419 /locus_tag="ClothDRAFT_1533" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: similar to pleckstrin homology-like domain, family B, member 1" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429672.1" /db_xref="GI:256004696" /translation="MGNFIDRTEEKEAGSTLPEIVYNQEKDFYRAIGGELRMKAEGLF KKAKEKGISIEDVSINILKENRAEFPGLGEVELPTFIVKIRGRDMSTGQIIVDGKQID YYNRYQKYIAKKIEEKNMVGNDEAKDSQKNRVKENPEFYLTDWEKFQIGKDIIEDKEF GLEKTITGACDRIIRKLMGENDWLSPQEARLLDEEFNSVQSSMQKSQEKKQKELIRKK KATPRQINYFKQRIKNMGMNPDDPKMLSKIFDRVGIEPADISELSIADMSKIIESLND IAPKIREGNENMSEIREQ" gene 11687..12289 /locus_tag="ClothDRAFT_1534" CDS 11687..12289 /locus_tag="ClothDRAFT_1534" /inference="protein motif:TFAM:TIGR00172" /note="TIGRFAM: maf protein; PFAM: Maf family protein; KEGG: bba:Bd0469 maf protein" /codon_start=1 /transl_table=11 /product="maf protein" /protein_id="ZP_05429673.1" /db_xref="GI:256004697" /db_xref="InterPro:IPR003697" /translation="MVKIVLASGSPRRSELLKQIGLDFEIVLSDIDESNEENLKANEL VQHLAYKKAYDVAKKVANRENGKERYLVVGADTVVVKDRIMGKPKDRDDAVRMLKHLS GSWHEVMTGIALIDTKDFRSVTSVEITKVKMKELTDDTILAYVDTKEPMDKAGAYGIQ EKGAILVERIEGCYFNVVGLPLGRLSDLLKDFGVSVLKKI" misc_feature 11696..12253 /locus_tag="ClothDRAFT_1534" /note="Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555" /db_xref="CDD:29954" misc_feature order(11708..11710,11723..11725,11783..11785,11840..11842, 11912..11914,11945..11947) /locus_tag="ClothDRAFT_1534" /note="active site" /db_xref="CDD:29954" misc_feature order(11822..11824,12047..12064) /locus_tag="ClothDRAFT_1534" /note="dimer interface; other site" /db_xref="CDD:29954" gene 12367..13389 /locus_tag="ClothDRAFT_1535" CDS 12367..13389 /locus_tag="ClothDRAFT_1535" /inference="protein motif:TFAM:TIGR00904" /note="TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; cell division protein FtsA; KEGG: afw:Anae109_0117 cell shape determining protein MreB" /codon_start=1 /transl_table=11 /product="cell shape determining protein, MreB/Mrl family" /protein_id="ZP_05429674.1" /db_xref="GI:256004698" /db_xref="InterPro:IPR001023" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR004753" /translation="MGFFTRDIGIDLGTANTLVHVKGKGIVVREPSVVAINKKNGEIL AVGDAAKEMIGRTPGNIVAIRPMKDGVIADFEVTQSMLKYFIKKAMSKGVFGKPRVVI CVPSGVTEVEKRAVEEATLQAGAKEAYLIEEPMAAAIGANLPVEEPSGSMVVDIGGGT SEVAVISLGGIVTSKSLRIAGDELDDAIVHYIKKEYNLMVGERTAEEIKMSIGSAYPR AKEESMEIRGRDLITGLPKNIIITSSEVMEAIKEPINAIVEAIKFTLEKTPPELAADI MDRGIMLTGGGALLSGLDRLIREETGMPVNVAENPLDCVAVGSGKVLEDIETLRKVLI SPRKPR" misc_feature 12367..13371 /locus_tag="ClothDRAFT_1535" /note="rod shape-determining protein MreB; Provisional; Region: PRK13927" /db_xref="CDD:184401" misc_feature 12823..13263 /locus_tag="ClothDRAFT_1535" /note="Cell division protein FtsA; Region: FtsA; cl11496" /db_xref="CDD:159497" gene 13406..14269 /locus_tag="ClothDRAFT_1536" CDS 13406..14269 /locus_tag="ClothDRAFT_1536" /inference="protein motif:TFAM:TIGR00219" /note="TIGRFAM: rod shape-determining protein MreC; PFAM: Rod shape-determining protein MreC; KEGG: dol:Dole_0593 rod shape-determining protein MreC" /codon_start=1 /transl_table=11 /product="rod shape-determining protein MreC" /protein_id="ZP_05429675.1" /db_xref="GI:256004699" /db_xref="InterPro:IPR005223" /db_xref="InterPro:IPR007221" /translation="MRFVKNKHFILLTVTVAILIIIGLSARKNSKINTVSNVVTVALS PFQEFINYLGDRVEGAAKYFQDIEALSQENEALKVRISELEKEVKELSDYREKNKELK EALNIKDQFSDVEFLGANIIAKDMGNWFHTFTIDRGIADGVTVDSAVITKDGLVGRVI STDLFTSKVITIIDEDSTVSARVSKTRDLVFVKGDLQLKNQGLCRLDNIFPDMDIAVG DTIETSGLGGIYPKGIIIGKVKEVRRKTNDLNRYAIIEPAVDFKRLEEVFVLESKNNK DNYEKVGEDNK" misc_feature 13406..14233 /locus_tag="ClothDRAFT_1536" /note="rod shape-determining protein MreC; Provisional; Region: PRK13922" /db_xref="CDD:184397" sig_peptide 13406..13492 /locus_tag="ClothDRAFT_1536" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.930) with cleavage site probability 0.704 at residue 29" misc_feature 13760..14227 /locus_tag="ClothDRAFT_1536" /note="rod shape-determining protein MreC; Region: MreC; cl12287" /db_xref="CDD:187204" gene 14266..14796 /locus_tag="ClothDRAFT_1537" CDS 14266..14796 /locus_tag="ClothDRAFT_1537" /inference="protein motif:TFAM:TIGR03426" /note="TIGRFAM: rod shape-determining protein MreD; KEGG: gme:Gmet_0927 rod shape-determining protein MreD, putative" /codon_start=1 /transl_table=11 /product="rod shape-determining protein MreD" /protein_id="ZP_05429676.1" /db_xref="GI:256004700" /db_xref="InterPro:IPR007227" /translation="MRAKPVRVKIISYAALIFIIALIQSTVLESISIFNIKPNLLLIF IISVALLGSNIEGAVTGFLCGLTQDMLSGRVIGFYALLGLYLGLGIALINKRLYKENV LVAIFTTFVSSIIYEFAVYFFVNVFKGSLELIFPFRYIILPEAVYNSAVSIVIFLIVL KINHWSEELERLSRRY" misc_feature 14287..14751 /locus_tag="ClothDRAFT_1537" /note="rod shape-determining protein MreD; Region: MreD; cl01087" /db_xref="CDD:186325" gene 14910..15197 /locus_tag="ClothDRAFT_1538" CDS 14910..15197 /locus_tag="ClothDRAFT_1538" /inference="similar to AA sequence:KEGG:DP1083" /note="KEGG: dps:DP1083 penicillin-binding protein 2" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2" /protein_id="ZP_05429677.1" /db_xref="GI:256004701" /translation="MGEKKPVDKISERYRIMVISFTLIFAVIVAQLVNLQIINGEYYD EQSQTKLLAERDIIAPRGKIVDRNGVPIAVNRMGYAVKIAKTGMTEKEKMK" misc_feature 14952..>15191 /locus_tag="ClothDRAFT_1538" /note="penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423" /db_xref="CDD:163256" misc_feature 15078..>15158 /locus_tag="ClothDRAFT_1538" /note="Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717" /db_xref="CDD:146381" gene 15194..17038 /locus_tag="ClothDRAFT_1539" CDS 15194..17038 /locus_tag="ClothDRAFT_1539" /EC_number="2.4.1.129" /inference="protein motif:PRIAM:2.4.1.129" /note="PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: glo:Glov_2492 penicillin-binding protein 2" /codon_start=1 /transl_table=11 /product="Peptidoglycan glycosyltransferase" /protein_id="ZP_05429678.1" /db_xref="GI:256004702" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /translation="MILKLINIFEKNGDSYEKNLSNYLTFNPIAFGPKNQSEDALQRW KKDMVVKADDMKLLETPEDVFKYFRKKFYIDDTYTDEEAYKIMTIKYDMLIKGYTATN PLLVAKDVKVETVAQIEERSHEFPGVIIDVIPQRKYVDASSVAHVLGHIGVISEEEYK TYKDNGYTMNDMIGKGGIEKTQESQLRGINGKKRVEVDTNGRLTAELSSEPAIPGNDV VLTIDMRLQKVAMKSLEENIERIRSKADYKKNFGDASSGAAVVIDVNSGEVLAMASYP SYDPSVFLAGPQDKEAQKTINALLTDEKNKPLFNRAIQGAYTPGSTFKPLISIAGLET GAITPQNSYITDRGTHVIGGWTFKCMEYPTYGHGTIDVVKALATSCNIYFHELGVKVG IDNIDLWAKRFGLGEYTGIELPWENKGIRANRQTKKELRNDEWRPADTAQTAIGQFDN AFTPIQLANYVSTLANGGKKYKPHIVKEIRKYDGSTVLKSEPEYEQLPIKEETMKIVH EGMVAVANTEDGTVNQLFSDFPFKVAGKTGTPETGLEHLGQSSNGVFIAYAPADNPQV AVAVVIEHGVWGSEVAPVAKDILREYFGMNNDSLPKDQIVVDKPSFTR" misc_feature <15428..15817 /locus_tag="ClothDRAFT_1539" /note="Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717" /db_xref="CDD:146381" misc_feature 15962..16960 /locus_tag="ClothDRAFT_1539" /note="Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039" /db_xref="CDD:154162" gene 17104..17787 /locus_tag="ClothDRAFT_1540" CDS 17104..17787 /locus_tag="ClothDRAFT_1540" /inference="protein motif:TFAM:TIGR01222" /note="TIGRFAM: septum site-determining protein MinC; PFAM: Septum formation inhibitor MinC; KEGG: sfu:Sfum_1280 septum site-determining protein MinC" /codon_start=1 /transl_table=11 /product="septum site-determining protein MinC" /protein_id="ZP_05429679.1" /db_xref="GI:256004703" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /translation="MSEGSVIFKGSLNGLTIIMKEEEDYDSILKQIEDKIASSGRFFK GAILSVKYRGKKLTEEQERKLFELLRDKSGAKIKSLEEDTEEPVKPEPVQQQPRFRSK IRMSNFYFKGLEEGITKFHRGTVRSGQLVSFDGNLVIIGDVNPGGEVCATGHVIVMGS LRGMVHAGANGNREALVVALNLQPTQLRIADVITRPPDEKETVGQFFPELAYVKDGMV YIERYLPAR" misc_feature 17104..17778 /locus_tag="ClothDRAFT_1540" /note="septum formation inhibitor; Reviewed; Region: minC; PRK00513" /db_xref="CDD:179052" misc_feature 17455..17772 /locus_tag="ClothDRAFT_1540" /note="Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775" /db_xref="CDD:146423" gene 18002..18802 /locus_tag="ClothDRAFT_1541" CDS 18002..18802 /locus_tag="ClothDRAFT_1541" /inference="protein motif:TFAM:TIGR01968" /note="TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; KEGG: sfu:Sfum_1281 septum site-determining protein MinD" /codon_start=1 /transl_table=11 /product="septum site-determining protein MinD" /protein_id="ZP_05429680.1" /db_xref="GI:256004704" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /translation="MSEVIVITSGKGGVGKTTTTANIGTGLALQGKKVVLIDTDIGLR NLDVVMGLENRIVYDLVDVVEGTCRIKQALIKDKRFEGLYLLPAAQTRDKTAVNPEGM IKLCEELRKDFDYILIDCPAGIEQGFKNAIAGADRAIVVTTPEVSAVRDADRIIGLLE ANELKNPKLLINRVRQDMVKRGDMMSIDDIIDILAIDLIGVVPDDEKIIVSTNKGEPA VTDNKSAAGAAYRAITRRIMGEDVPLLNLGSEDGFMFKIKKLFGLKVN" misc_feature 18062..18784 /locus_tag="ClothDRAFT_1541" /note="septum site-determining protein MinD; Region: minD_bact; TIGR01968" /db_xref="CDD:131023" misc_feature 18062..18691 /locus_tag="ClothDRAFT_1541" /note="Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036" /db_xref="CDD:73299" misc_feature 18113..18121 /locus_tag="ClothDRAFT_1541" /note="Switch I; other site" /db_xref="CDD:73299" misc_feature 18356..18370 /locus_tag="ClothDRAFT_1541" /note="Switch II; other site" /db_xref="CDD:73299" gene 18816..19100 /locus_tag="ClothDRAFT_1542" CDS 18816..19100 /locus_tag="ClothDRAFT_1542" /inference="protein motif:TFAM:TIGR01215" /note="TIGRFAM: cell division topological specificity factor MinE; PFAM: Septum formation topological specificity factor MinE; KEGG: sfu:Sfum_1282 cell division topological specificity factor MinE" /codon_start=1 /transl_table=11 /product="cell division topological specificity factor MinE" /protein_id="ZP_05429681.1" /db_xref="GI:256004705" /db_xref="InterPro:IPR005527" /translation="MLLDLSKIFGKSKNSKDLAKERLKLVLIHDRANVSPQFLEMVKG EIIKVISNYMDVDEESLDIQMTRTKSEDGNSVVPALVANIPIRSVKNSGK" misc_feature 18822..19097 /locus_tag="ClothDRAFT_1542" /note="Septum formation topological specificity factor MinE; Region: MinE; cl00538" /db_xref="CDD:186067" gene 19121..19516 /locus_tag="ClothDRAFT_1543" CDS 19121..19516 /locus_tag="ClothDRAFT_1543" /EC_number="4.2.3.3" /inference="protein motif:TFAM:TIGR00160" /note="KEGG: esa:ESA_02385 methylglyoxal synthase; TIGRFAM: methylglyoxal synthase; PFAM: MGS domain protein" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="ZP_05429682.1" /db_xref="GI:256004706" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /translation="MNIALIAHDKKKELMASFCIAYRSILKNHTLFATGTTGAIIVEA TGLNVHRFLPGVMGEQQISARAAYNELDLVIFFRDPISAKSDEPDIHSLLRECDINNI PFATNLGTAEMLIKGLERGDLDWRELIKK" misc_feature 19124..19465 /locus_tag="ClothDRAFT_1543" /note="Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422" /db_xref="CDD:29634" misc_feature order(19136..19138,19154..19156,19220..19222,19226..19231, 19280..19285,19295..19297,19376..19378) /locus_tag="ClothDRAFT_1543" /note="active site" /db_xref="CDD:29634" misc_feature order(19145..19147,19226..19228,19277..19282,19286..19291, 19298..19303,19319..19321,19358..19360,19385..19387, 19394..19396,19403..19411,19415..19432,19439..19450, 19457..19459) /locus_tag="ClothDRAFT_1543" /note="dimer interfaces; other site" /db_xref="CDD:29634" misc_feature order(19295..19297,19376..19378) /locus_tag="ClothDRAFT_1543" /note="catalytic residues; other site" /db_xref="CDD:29634" gene complement(19574..19837) /locus_tag="ClothDRAFT_1544" CDS complement(19574..19837) /locus_tag="ClothDRAFT_1544" /inference="protein motif:PFAM:PF03698" /note="PFAM: protein of unknown function UPF0180" /codon_start=1 /transl_table=11 /product="protein of unknown function UPF0180" /protein_id="ZP_05429683.1" /db_xref="GI:256004707" /db_xref="InterPro:IPR005370" /translation="MKPRVAVEENLTPIEEFLSERGYEVENINFTDAEEISSLVDEFD AFVVSGLDSNMLGIEDTETDAIIIDASGMTPEEVYDELEARLE" misc_feature complement(19577..19831) /locus_tag="ClothDRAFT_1544" /note="Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214" /db_xref="CDD:186621" gene 20026..20943 /locus_tag="ClothDRAFT_1545" CDS 20026..20943 /locus_tag="ClothDRAFT_1545" /inference="protein motif:PFAM:PF01551" /note="PFAM: Peptidase M23; KEGG: afw:Anae109_0789 peptidase M23B" /codon_start=1 /transl_table=11 /product="Peptidase M23" /protein_id="ZP_05429684.1" /db_xref="GI:256004708" /db_xref="InterPro:IPR016047" /translation="MLKNIKKLYGDVFAVDDIVYRQRYPRYNVQQSLRRTRKSKRKRG SGERLNLVQKFVIQTVVCVVVLLTAVLIKNINSPITNYCKDKIKGILSYNIDINSVFG KIDSFLASAGNNKSVIKEDESVEDVVENVNEKSGSQKDALESENPAEEEGTYVKSAET VLTDNETENQEDLPNSFIIPVGGIIGALYGERVYTPEGTEEIHQGIDIKALKGTPVKA AAEGEVIEAGENQIYGKYIKIKHGEDIISLYAHCSDLLVSKGQNVKKGETVAKVGNTG TSQEPHLHFEVWEKGTPVNPLDYIQSPSN" misc_feature 20632..20913 /locus_tag="ClothDRAFT_1545" /note="Peptidase family M23; Region: Peptidase_M23; pfam01551" /db_xref="CDD:144954" gene 21123..21884 /locus_tag="ClothDRAFT_1546" CDS 21123..21884 /locus_tag="ClothDRAFT_1546" /inference="protein motif:PFAM:PF02163" /note="PFAM: peptidase M50; KEGG: afw:Anae109_3134 peptidase M50" /codon_start=1 /transl_table=11 /product="peptidase M50" /protein_id="ZP_05429685.1" /db_xref="GI:256004709" /db_xref="InterPro:IPR008915" /translation="MAIHETAHIVAAAVQKRILVSVRITALGLNAVIKEKHDVDANRF LINISGPCANILMFFICIIIKTYYFNAGYNMRFFIYANICLALFNMLPILPLDGGRIL KDVLVSKMGLVRGCKYTRRLSLIFSALLLVLGIFQYIISKYNFSILLIAGYMLYFQKS DRPEEILMNIRNLLFKRSRFLKKGVYPGRELVVLESTRLGELIKSMDFDRFHIIYVVN ENMRVVRVFTEQEIIDYIMKYNADISFRDLMETVD" misc_feature <21129..21590 /locus_tag="ClothDRAFT_1546" /note="SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161" /db_xref="CDD:100082" misc_feature order(21132..21137,21144..21146,21387..21389,21411..21413) /locus_tag="ClothDRAFT_1546" /note="active site" /db_xref="CDD:100082" misc_feature 21387..21398 /locus_tag="ClothDRAFT_1546" /note="putative substrate binding region; other site" /db_xref="CDD:100082" gene complement(21948..22823) /locus_tag="ClothDRAFT_1547" CDS complement(21948..22823) /locus_tag="ClothDRAFT_1547" /EC_number="1.5.1.20" /inference="protein motif:TFAM:TIGR00676" /note="KEGG: afw:Anae109_2667 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase" /codon_start=1 /transl_table=11 /product="5,10-methylenetetrahydrofolate reductase" /protein_id="ZP_05429686.1" /db_xref="GI:256004710" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR004620" /translation="MNLVDLFKKKKPVISFEIFPPKLDTPIESIFGTLEQFKELKPDF ISVTYGAGGSAKDRTIEIASKIKNEYGIESMAHLTCVGHSKEEIDALLTSMREHNLEN ILALRGDPPANQPDFDFSNNAFKYANELIAHVRKQNRNDFCIAAAAYVEGHVNSKRLK DDLLYLKQKVDTGVDFLVTQLFFDNRLFYDFLDKTASIGITCPITPGIMPIFKADQIK RITYLCGASIPAKLVIMMDKYGDNDEDMRKAGIEYASNQIRDLIDNGVDGIHLLTMNR PKSTREILTNIGLLK" misc_feature complement(21963..22784) /locus_tag="ClothDRAFT_1547" /note="Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537" /db_xref="CDD:29637" misc_feature complement(order(22008..22010,22284..22286,22290..22292, 22317..22322,22329..22331,22338..22340,22359..22361, 22365..22367,22377..22379,22383..22385,22443..22448, 22500..22508,22593..22595,22677..22679)) /locus_tag="ClothDRAFT_1547" /note="FAD binding site; other site" /db_xref="CDD:29637" gene 23234..24016 /locus_tag="ClothDRAFT_1548" CDS 23234..24016 /locus_tag="ClothDRAFT_1548" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429687.1" /db_xref="GI:256004711" /translation="MKPKMFFKAITKFRNILLLAIVIGIFFATLNNISNVPFLLIGAA CYIYSVIRTLKNPRFMAEFNREIQFESIQDLNEECNRLYQNAFKRLPAGMRERIRNIY KEKQALVAYYVRTKSDPVKQRIVEQALNLVIVYFKLMLNYSIRIKEVNSANVQKIVER INANKRKLQLLTNPKAVEDLERAVELDEKIIERINNEKIELETISSKLDYIESAILMF KHQIISNASTEPIAEDIDNVINEAIALDNALTSHRNEKLRLY" sig_peptide 23234..23329 /locus_tag="ClothDRAFT_1548" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.804) with cleavage site probability 0.372 at residue 32" gene 24032..25201 /locus_tag="ClothDRAFT_1549" CDS 24032..25201 /locus_tag="ClothDRAFT_1549" /inference="protein motif:PFAM:PF00465" /note="PFAM: iron-containing alcohol dehydrogenase; KEGG: apj:APJL_1902 NADH-dependent butanol dehydrogenase 1" /codon_start=1 /transl_table=11 /product="iron-containing alcohol dehydrogenase" /protein_id="ZP_05429688.1" /db_xref="GI:256004712" /db_xref="InterPro:IPR001670" /translation="MINFVYKNPTKIIFGRGTELKVGEEVRQYSGKVLLHYGGGSIKK TGLYDRVVNSLKQAGVEVVELGGVMPNPRLGLVNEGIKICREKGIDFILAVGGGSAID SAKAIAVGVPYDGDVWDFFCGKAEPKEALPVGVVLTIPAAGSEASPNSVITREDGLYK RGMYSELIRPVFAIMNPELTYTLPAYQTACGTADIMAHIMERYFTNETHTDLTDRLCE ATLKTMIKNVPIALEEPDNYNARAEIMWAGTIAHNGLLGTGRIEDWASHNIEHEISAI YDVAHGAGLAVVFPAWMKYVYKNNLDRFVQFAVRVWNVEMNFDEPERTALEGIERLKK FFKEIGLPVSLKEMNIGDDRLEEMASKCTNGGKATIGNFVKLNREDVYNILKLAV" misc_feature 24038..25189 /locus_tag="ClothDRAFT_1549" /note="Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187" /db_xref="CDD:173946" misc_feature 24056..25009 /locus_tag="ClothDRAFT_1549" /note="Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465" /db_xref="CDD:144163" misc_feature order(24056..24058,24062..24067,24071..24076,24695..24697, 24707..24709,24755..24760,24767..24769) /locus_tag="ClothDRAFT_1549" /note="dimer interface; other site" /db_xref="CDD:173946" misc_feature order(24146..24154,24239..24244,24320..24328,24335..24337, 24443..24448,24455..24457,24461..24463,24470..24472, 24476..24478,24482..24484,24509..24511,24566..24568, 24575..24580,24611..24613,24623..24625,24830..24832, 24872..24874) /locus_tag="ClothDRAFT_1549" /note="active site" /db_xref="CDD:173946" misc_feature order(24611..24613,24623..24625,24830..24832,24872..24874) /locus_tag="ClothDRAFT_1549" /note="metal-binding site" /db_xref="CDD:173946" gene complement(25289..25945) /locus_tag="ClothDRAFT_1550" CDS complement(25289..25945) /locus_tag="ClothDRAFT_1550" /EC_number="2.1.1.33" /inference="protein motif:TFAM:TIGR00091" /note="KEGG: gsu:GSU0521 methyltransferase, putative; TIGRFAM: tRNA (guanine-N(7)-)-methyltransferase; PFAM: putative methyltransferase" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="ZP_05429689.1" /db_xref="GI:256004713" /db_xref="InterPro:IPR002345" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR004395" /translation="MRLRKKPWARPALEACSFFVINPTEYKGKWREVFGNSNEIWLEL GCGKGGFISKLASTNPDKNFIAVDIKDEVLALAMKKIENEYALIGAETKNIRLMAHEI MLIHRMLDENDQIGRIFINFCNPWPKNRHKARRLTHPNQLNQYRTFLAPNGQIWFKTD DTMLFQDSIKYFEQCNFNIVYLTEDLHASGFEGNIETEHERMFLEQGCKIKFLIAEKK " misc_feature complement(25328..25939) /locus_tag="ClothDRAFT_1550" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011" /db_xref="CDD:187159" gene 26202..26594 /locus_tag="ClothDRAFT_1551" CDS 26202..26594 /locus_tag="ClothDRAFT_1551" /inference="protein motif:PFAM:PF01894" /note="PFAM: protein of unknown function UPF0047; KEGG: dat:HRM2_22690 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function UPF0047" /protein_id="ZP_05429690.1" /db_xref="GI:256004714" /db_xref="InterPro:IPR001602" /translation="MLERLSIRTSARTAMIDITSKVQQVVERSGVKSGICTVFVPHTT AGITINENADPDVVSDILTEINKIVPFEDGYSHGEGNSAAHIKASLFGSSQQIIIENS RLLLGTWQGIYFCEFDGPRNREVYVKIT" misc_feature 26247..26588 /locus_tag="ClothDRAFT_1551" /note="Uncharacterized protein family UPF0047; Region: UPF0047; cl00439" /db_xref="CDD:153768" gene 26933..28039 /locus_tag="ClothDRAFT_1552" CDS 26933..28039 /locus_tag="ClothDRAFT_1552" /EC_number="3.5.4.26" /EC_number="1.1.1.193" /inference="protein motif:TFAM:TIGR00326" /note="KEGG: pca:Pcar_1445 riboflavin biosynthesis protein RibD; TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: bifunctional deaminase-reductase domain protein; CMP/dCMP deaminase zinc-binding" /codon_start=1 /transl_table=11 /product="riboflavin biosynthesis protein RibD" /protein_id="ZP_05429691.1" /db_xref="GI:256004715" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /translation="MIKLSEKEFFMSRAIKLAKLGWGKTNPNPLVGAVVVKDGKIIAE GYHKQLGGPHAEVEAFNNAKEDVAGGTLYVNLEPCSHYGRTPPCAQKIIDVGIKKVVA AIKDPNPKVSGRGFEMLKNAGIEVEVGVLEEEAIRLNEIFITYIVKKKPFVILKTAMT LDGKIATASGDSKWVTGEKARNHVHVIRDRVAAVMVGINTVLKDNPYLTTRLPDKEGS DPVRIVVDSKGSIPLDSNVINSNSKAGVILATTSRIDKEKEKMLIDKGVKIIKADGSD GRVDLKLLMDELYKLEIDSVLLEGGGTLNSSAISAGIVDKVMCFISPKIVGGENAPTS VEGIGALRMCEAIGVKNISVVKFGEDILLEGYIE" misc_feature 26963..28021 /locus_tag="ClothDRAFT_1552" /note="riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326" /db_xref="CDD:161819" misc_feature 26963..27301 /locus_tag="ClothDRAFT_1552" /note="Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284" /db_xref="CDD:29827" misc_feature order(27092..27100,27164..27169,27194..27196) /locus_tag="ClothDRAFT_1552" /note="catalytic motif; other site" /db_xref="CDD:29827" misc_feature order(27092..27094,27098..27100,27167..27169,27194..27196) /locus_tag="ClothDRAFT_1552" /note="Zn binding site; other site" /db_xref="CDD:29827" misc_feature 27377..28030 /locus_tag="ClothDRAFT_1552" /note="Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161" /db_xref="CDD:185804" gene 28118..28774 /locus_tag="ClothDRAFT_1553" CDS 28118..28774 /locus_tag="ClothDRAFT_1553" /EC_number="2.5.1.9" /inference="protein motif:TFAM:TIGR00187" /note="KEGG: apa:APP7_0407 riboflavin synthase subunit alpha; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein" /codon_start=1 /transl_table=11 /product="riboflavin synthase, alpha subunit" /protein_id="ZP_05429692.1" /db_xref="GI:256004716" /db_xref="InterPro:IPR001783" /translation="MFTGIVEEIGLVKEIIPGNKSIKLTIKCEKIMDDVKVGDSIAVN GICLTVTSLDNGAFTADVMPQTMRKTNLGNLRTGEKVNLERALRPVDRMGGHIVSGHI DGTGVILSKEEEDNAIWLEISAPSDILKYIVVRGSVALDGVSLTVAYVDEKSFKVSLI PHTASVTILGSKKPGDRINIECDMLGKYVEKLMCFDRQDKKEEKKSVTLDFLREHGFA " misc_feature 28118..28693 /locus_tag="ClothDRAFT_1553" /note="riboflavin synthase subunit alpha; Provisional; Region: PRK09289" /db_xref="CDD:181760" misc_feature 28124..28375 /locus_tag="ClothDRAFT_1553" /note="Lumazine binding domain; Region: Lum_binding; pfam00677" /db_xref="CDD:144321" misc_feature 28412..28666 /locus_tag="ClothDRAFT_1553" /note="Lumazine binding domain; Region: Lum_binding; pfam00677" /db_xref="CDD:144321" gene 28814..30055 /locus_tag="ClothDRAFT_1554" CDS 28814..30055 /locus_tag="ClothDRAFT_1554" /inference="protein motif:TFAM:TIGR00506" /note="TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II; PFAM: 34-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II; KEGG: gsu:GSU1690 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II" /codon_start=1 /transl_table=11 /product="3,4-dihydroxy-2-butanone 4-phosphate synthase" /protein_id="ZP_05429693.1" /db_xref="GI:256004717" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /translation="MNFDTIESAIEDIRQGKMIVVVDDEDRENEGDLLMAAELVTPEH INFMATYGRGMICAPITEARAKELGLELMVTKNSEHMRTAFTVTVDHKSTTTGISAFE RAKTIKELSNPDAKPDDFVRPGHVFPLIAKEGGVLKRAGHTEAAVDFAKLAGLYPAGV ICEIMNDDGTMARVPQLMEFVKKHGLKLVTIADLIKYRRNNEKLIRRAAEAKLPTEYG DFKIVAYENVINGEHHVALVKGDVANSDEPVMVRVHSECLTGDAFHSLRCDCGEQLHK AMEMIGKEDKGVLLYMRQEGRGIGLVNKIRAYELQDQGKDTVEANVLLGFPPDLREYG IGAQILYDLGVRKIRLLTNNPKKLIGLGGHGLEIVERVPIEIKGNEINSFYLKTKKEK MGHLLTSINTTEHQEGESNGN" misc_feature 28814..30004 /locus_tag="ClothDRAFT_1554" /note="bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311" /db_xref="CDD:181774" misc_feature 28829..29407 /locus_tag="ClothDRAFT_1554" /note="3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336" /db_xref="CDD:185917" misc_feature 29423..30004 /locus_tag="ClothDRAFT_1554" /note="GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641" /db_xref="CDD:88311" misc_feature order(29435..29455,29477..29479,29483..29491,29510..29512, 29516..29518,29522..29524,29579..29581,29585..29590, 29594..29608,29612..29614,29633..29638,29645..29647, 29684..29686,29690..29692,29714..29719,29726..29731, 29735..29740,29747..29749) /locus_tag="ClothDRAFT_1554" /note="dimerization interface; other site" /db_xref="CDD:88311" misc_feature order(29567..29584,29588..29590,29615..29617,29621..29623, 29630..29632,29693..29704,29723..29725,29735..29737, 29744..29746,29762..29764,29798..29800,29804..29806, 29867..29875,29882..29884) /locus_tag="ClothDRAFT_1554" /note="active site" /db_xref="CDD:88311" gene 30045..30512 /locus_tag="ClothDRAFT_1555" CDS 30045..30512 /locus_tag="ClothDRAFT_1555" /EC_number="2.5.1.9" /inference="protein motif:TFAM:TIGR00114" /note="KEGG: gur:Gura_2180 6,7-dimethyl-8-ribityllumazine synthase; TIGRFAM: 6,7-dimethyl-8-ribityllumazine synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase" /protein_id="ZP_05429694.1" /db_xref="GI:256004718" /db_xref="InterPro:IPR002180" /translation="MAIKTNEGKLIASGLKFGVVVARFNEFISSKLLGGVIDGLIRHG ASEEDIEISWVPGAFEIPLVAQKMANSKKFDAIICIGAVIRGSTPHFDYVANEMSKGI AKVSLDTGIPIAFGVLTTDTIEQAIERAGTKVGNKGYDAAVTAIEMANLLKMI" misc_feature 30051..30509 /locus_tag="ClothDRAFT_1555" /note="6,7-dimethyl-8-ribityllumazine synthase; Region: DMRL_synthase; cl00317" /db_xref="CDD:185900" gene complement(30604..31245) /locus_tag="ClothDRAFT_1556" CDS complement(30604..31245) /locus_tag="ClothDRAFT_1556" /inference="protein motif:PFAM:PF07238" /note="PFAM: type IV pilus assembly PilZ" /codon_start=1 /transl_table=11 /product="type IV pilus assembly PilZ" /protein_id="ZP_05429695.1" /db_xref="GI:256004719" /db_xref="InterPro:IPR009875" /translation="MEIKVGDLVSIRHFSGTKLFKSLVLESNNDEVLLKLTEDIALLN CSIGDPIVLGCELEENVYISSCTTLNVDKQQNTLKLKIDNYETTSNKRLFVRFPVSLY AEARIGESNKKYLAIVKNISFNGMMIHTKEDFPLFQELKFDIHADIPIHLKATIIRKV KDEYNYEYGLKINYTDVHTPNLLKKYLILLKKEQEEFIKKFKEEQNDTPQDTK" misc_feature complement(30709..30978) /locus_tag="ClothDRAFT_1556" /note="PilZ domain; Region: PilZ; cl01260" /db_xref="CDD:163963" gene 31773..31847 /locus_tag="ClothDRAFT_R0030" /note="tRNA-Gly2" tRNA 31773..31847 /locus_tag="ClothDRAFT_R0030" /product="tRNA-Gly" gene 31959..32032 /locus_tag="ClothDRAFT_R0031" /note="tRNA-Gly3" tRNA 31959..32032 /locus_tag="ClothDRAFT_R0031" /product="tRNA-Gly" gene 32413..32730 /locus_tag="ClothDRAFT_1557" CDS 32413..32730 /locus_tag="ClothDRAFT_1557" /inference="protein motif:PFAM:PF00404" /note="PFAM: cellulosome protein dockerin type I" /codon_start=1 /transl_table=11 /product="cellulosome protein dockerin type I" /protein_id="ZP_05429696.1" /db_xref="GI:256004720" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MSRRGALVLLVISLLVTAFLPTAVFAQDVPFSGKSDNVPSFTQP IPVKHLYELIHLCIWERGYDRLVDFNSDGSVNSTDLMILNRAVLGLGGLPVPIEIGDY RID" sig_peptide 32413..32493 /locus_tag="ClothDRAFT_1557" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 at residue 27" gene 32944..33900 /locus_tag="ClothDRAFT_1558" CDS 32944..33900 /locus_tag="ClothDRAFT_1558" /inference="protein motif:TFAM:TIGR00679" /note="TIGRFAM: HPr(Ser) kinase/phosphatase; PFAM: HPr serine kinase domain protein; KEGG: ank:AnaeK_0153 HPr kinase" /codon_start=1 /transl_table=11 /product="HPr kinase" /protein_id="ZP_05429697.1" /db_xref="GI:256004721" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /translation="MSSDAAYSVTLKKLQKALSLELVTADDEDRLENILVTSPEVNRP GLQLVGYLEYFGTDRIQMIGKVETSYLAGLTSEERYSRLDEFFKCGFPCMVVARGLEV FPEMLEVSRKYGIPIFRTKETTSRVLSALISYLNVELAERTREHGVLVEVFGEGILIL GESGVGKSETALELVKRGHRLVADDVVEIRRVSEKTLFGTAPDEIRHFIEIRGVGILD VKNLYGVGAVKPTENINLVIQLEFWDQKKDYERLGLVDDYKEILGINIPCLTIPVRPG RNLAIIVEVAALNNRQKKMGYNAARALNERIIGKGRMRPSYE" misc_feature 32962..33351 /locus_tag="ClothDRAFT_1558" /note="DRTGG domain; Region: DRTGG; cl12147" /db_xref="CDD:159807" misc_feature 32965..33864 /locus_tag="ClothDRAFT_1558" /note="HPr kinase/phosphorylase; Provisional; Region: PRK05428" /db_xref="CDD:180075" misc_feature 33364..33810 /locus_tag="ClothDRAFT_1558" /note="HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918" /db_xref="CDD:29833" misc_feature order(33373..33375,33379..33381,33430..33435,33442..33444, 33457..33459,33469..33471,33496..33501,33505..33507, 33553..33555,33571..33573,33583..33591,33604..33606, 33694..33702,33751..33753,33784..33786,33793..33795) /locus_tag="ClothDRAFT_1558" /note="Hpr binding site; other site" /db_xref="CDD:29833" misc_feature order(33379..33381,33433..33435,33439..33447,33493..33498, 33571..33573,33577..33579) /locus_tag="ClothDRAFT_1558" /note="active site" /db_xref="CDD:29833" misc_feature order(33451..33453,33457..33459,33469..33474,33481..33483, 33553..33555,33565..33567,33583..33585,33589..33597, 33604..33612,33748..33750,33796..33801,33805..33807) /locus_tag="ClothDRAFT_1558" /note="homohexamer subunit interaction site; other site" /db_xref="CDD:29833" gene 33934..34659 /locus_tag="ClothDRAFT_1559" CDS 33934..34659 /locus_tag="ClothDRAFT_1559" /inference="protein motif:PFAM:PF02811" /note="PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: swp:swp_1620 putative hydrolase" /codon_start=1 /transl_table=11 /product="PHP domain protein" /protein_id="ZP_05429698.1" /db_xref="GI:256004722" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /translation="MKFVVDTHTHTIASGHAYSTVQEMAKEASANGIEMFAITDHGPA MKGAPYLYHFGNLRVIPEVLYGVRILKGVEANIIDYSGGLDMPEEYLRRLDFVLASFH DICIEPKTLEEHTEAVINVLKNPYVDAIAHPGNPQFPLDIEKVVRAAKENGKFIELNN HSFVTRKGSEENCKEFARECKKQGVRIVCGSDSHISFEVGRFDRVYKLLEEVDMPCEL VMNTSVEKFDEYIKRKKERIRRK" misc_feature 33934..34623 /locus_tag="ClothDRAFT_1559" /note="putative hydrolase; Validated; Region: PRK09248" /db_xref="CDD:181726" misc_feature 33949..34170 /locus_tag="ClothDRAFT_1559" /note="DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481" /db_xref="CDD:128757" misc_feature 34192..34530 /locus_tag="ClothDRAFT_1559" /note="RNase P subunit p30; Region: RNase_P_p30; cl03389" /db_xref="CDD:186570" gene 34772..35686 /locus_tag="ClothDRAFT_1560" CDS 34772..35686 /locus_tag="ClothDRAFT_1560" /EC_number="1.1.1.158" /inference="protein motif:TFAM:TIGR00179" /note="KEGG: tgr:Tgr7_0771 UDP-N-acetylenolpyruvoylglucosamine reductase; TIGRFAM: UDP-N-acetylenolpyruvoylglucosamine reductase; PFAM: UDP-N-acetylenolpyruvoylglucosamine reductase domain protein; FAD linked oxidase domain protein" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="ZP_05429699.1" /db_xref="GI:256004723" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /translation="MEKELLAREIEKIAGQENVKLDEPMKNHTSFKVGGPADILVTPV SVSQLSQILKLCKNKSVPVFVMGNGTNLIVRDKGIRGVVVKIFDNLNQFTVKDDIITA YAGILLSRVSTIAYENGLTGLEFACGIPGTLGGAVAMNAGAYGGEMKDVVVETEYMDK DGEIRVVRDDGHQFGYRTSFIQKNSGIVIKTSMKLKKGNKEEIKALMDDLTQRRQEKQ PLEMPSAGSIFKRPEGYFAGKLIEDCGLRGHRIGGAEVSQKHCGFIVNTGDAKAKDIL DLIEYIRNTVKMKFGVDMQTEVRIVGEV" misc_feature 34811..35680 /locus_tag="ClothDRAFT_1560" /note="UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905" /db_xref="CDD:184385" misc_feature 34880..35275 /locus_tag="ClothDRAFT_1560" /note="FAD binding domain; Region: FAD_binding_4; cl10516" /db_xref="CDD:158898" misc_feature 35369..35677 /locus_tag="ClothDRAFT_1560" /note="UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873" /db_xref="CDD:111727" gene 35725..36600 /locus_tag="ClothDRAFT_1561" CDS 35725..36600 /locus_tag="ClothDRAFT_1561" /inference="protein motif:PFAM:PF03668" /note="PFAM: conserved hypothetical protein; KEGG: geo:Geob_2284 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429700.1" /db_xref="GI:256004724" /db_xref="InterPro:IPR005337" /translation="MRLLIITGISGAGKSLVVKYLEDIGFFCVDNLPPLLIGKFAEIC LKSRGKISKVALVIDIRGGELFNDLVPELNALKESGIDYEILFLEASDQVLIKRYKES RRIHPLAPEGRLIKGIKTEREILSQIRKNATYIIDTSNLTPRQLKEEILAIFVEGRKF DGMIVNIISFGFKYGIPIECDLVFDVRFIPNPYYIESMKYKTGKDEEVRNYVMSFAET AEFMTKLKDLVDFLIPNYIKEGKSQLVIGVGCTGGRHRSVAISEALFSYLCGREHRVF IDHRDIDKDGRSNRR" misc_feature 35725..36585 /locus_tag="ClothDRAFT_1561" /note="P-loop ATPase protein family; Region: ATP_bind_2; cl10035" /db_xref="CDD:186894" gene 36597..37916 /locus_tag="ClothDRAFT_1562" CDS 36597..37916 /locus_tag="ClothDRAFT_1562" /inference="protein motif:PFAM:PF01933" /note="PFAM: protein of unknown function UPF0052 and CofD; KEGG: mxa:MXAN_3230 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function UPF0052 and CofD" /protein_id="ZP_05429701.1" /db_xref="GI:256004725" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /translation="MKNDNWFRKKIAGYRWCLLIVFGIILISAGMLLAYRHDNTFDIF CSVLLFASGCIFIVVSIRLIAIDTVSKYAQNGINVVCCKDRDDNLYEKEFLDKGPKIV AIGGGTGLSTMLRGLKECSSNITAVVTVADDGGGSGILRQDLGILPPGDIRNCILALA NTEPIMEKLLQYRFQDGMLKGQSFGNLFLAAMDGISSSFEQAVQRMSDVLAVKGRVLP VTLEDIQLCAELEDGYVITGESQIGNHNSFHRCAIKRVYLEPGKVKPLDEVIEAIGEA DVIVLGPGSLFTSIIPNLLVDGVCDAIKKSKALKIYVCNVMTQPGETDGYSVSDHIKA LERHSFEGIVDYCIFNTADIPELLKKKYSEDGAQIVRVDYDELDKLGIKLLGGDFVCI TNGYIRHDTKKLAQAIMNLVIENVFGKDDRKSSGYVNTMKQFKNIVG" sig_peptide 36597..36701 /locus_tag="ClothDRAFT_1562" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.842) with cleavage site probability 0.832 at residue 35" misc_feature 36897..37823 /locus_tag="ClothDRAFT_1562" /note="family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187" /db_xref="CDD:132873" misc_feature 36897..37724 /locus_tag="ClothDRAFT_1562" /note="Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933" /db_xref="CDD:145222" misc_feature order(36912..36920,37446..37451,37461..37463,37548..37553) /locus_tag="ClothDRAFT_1562" /note="phosphate binding site; other site" /db_xref="CDD:132873" misc_feature order(36990..36992,37002..37004,37044..37046,37053..37055, 37152..37154) /locus_tag="ClothDRAFT_1562" /note="putative substrate binding pocket; other site" /db_xref="CDD:132873" misc_feature order(37131..37133,37146..37148,37155..37160,37167..37172, 37176..37181,37209..37211,37218..37223) /locus_tag="ClothDRAFT_1562" /note="dimer interface; other site" /db_xref="CDD:132873" gene 37943..39922 /locus_tag="ClothDRAFT_1563" CDS 37943..39922 /locus_tag="ClothDRAFT_1563" /EC_number="2.4.1.25" /inference="protein motif:TFAM:TIGR01561" /note="KEGG: geo:Geob_3238 glycogen debranching enzyme; TIGRFAM: glycogen debranching enzyme; PFAM: Amylo-alpha-16-glucosidase" /codon_start=1 /transl_table=11 /product="glycogen debranching enzyme" /protein_id="ZP_05429702.1" /db_xref="GI:256004726" /db_xref="InterPro:IPR006451" /db_xref="InterPro:IPR010401" /translation="MNFGKSSWRTYEQGIQREWLLTNGIGGFASSTIIGSNTRRYHGL LVAALKPPVSRHLILSKIDECVTVDNESFNLFSYEVPGFIMHGYHHLERFEYDMLPKY IYRVKDVYVEKEICMVYGENTVVVVYHVINGTGRTNLRLTPLVNFRDYHFNSGRAYMS FERKFEKDVLTVRPSCYDIDIKLYSTDGKFTELDDTWFYNMDYAVERERGLASTEDHY IPGYYDIEIKPLEEKYITFVATVEKNVNHRDGLKIIEKEKKRLKKLASKAGYKDELAK KLVLAADKFIVHRESTNAKTVIAGYPWFTDWGRDTMISLAGLTLATRRFEDAKEILYT FSKYVKDGLIPNMFPDAGHEPPYNTVDAALWYFEAVNKYVNYTHDYKFIKENIYSGLK QIIEYYSKGTHFNIKADEDYLISAGDEHTQLTWMDAKVGDWVVTPRHGKAVEINALWY NALKIMSQLSKHFKEDAGLYDEMAEKVKKSFEEKFWNEEKKCLYDCLTPNYKDDKVRP NQILAVSLSYPVIEGEKAKSVVDIVFKELYTAYGLRSLSPKEKEYVGVYMGDQYRRDG AYHQGTVWTWPLGHFITAYLRVNNYSPEARKMALRFIEPFKDHLQDACLGSVSEIFDG NEPLIPRGCFAQAWSVAEILRAYVEDVMQLVQLKH" misc_feature 37991..38650 /locus_tag="ClothDRAFT_1563" /note="Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439" /db_xref="CDD:152873" misc_feature 37994..39700 /locus_tag="ClothDRAFT_1563" /note="glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561" /db_xref="CDD:130624" misc_feature 38780..39877 /locus_tag="ClothDRAFT_1563" /note="Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801" /db_xref="CDD:186477" gene 39997..40950 /locus_tag="ClothDRAFT_1564" CDS 39997..40950 /locus_tag="ClothDRAFT_1564" /inference="protein motif:PFAM:PF02650" /note="PFAM: protein of unknown function DUF199" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF199" /protein_id="ZP_05429703.1" /db_xref="GI:256004727" /db_xref="InterPro:IPR003802" /translation="MSALSFSSAVKNELCRVETDRSSSLFELAAAARISGLIKVVNAN EINLRLVTENAAFARRIFSQIKDLYGINAEISIRRSPKLKKNIVYIIVLTSSKGLMRI LEDINIKVSEKVEYIPYARCMRKKEYRKAYLRGAFLASGSMSDPEKTYHLEITCHNMA LATEVSDLMDSFKLHSKVTKRKGNYVVYLKEGENIVDFLNIIGAHSALLELENIRILK EMRNNVNRIVNCETANLQKTVDASVRQVENINYIKEHLGFDKLPENLREIAKMRLAYS DATLKELGEMLNPPLGKSGVNHRLRKLDKIAESLRNMKGEL" misc_feature 40006..40941 /locus_tag="ClothDRAFT_1564" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481" /db_xref="CDD:31670" misc_feature 40057..40320 /locus_tag="ClothDRAFT_1564" /note="Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298" /db_xref="CDD:150898" gene 40953..41219 /locus_tag="ClothDRAFT_1565" CDS 40953..41219 /locus_tag="ClothDRAFT_1565" /inference="protein motif:TFAM:TIGR01003" /note="TIGRFAM: phosphocarrier, HPr family; PFAM: phosphoryl transfer system HPr; KEGG: pin:Ping_2439 phosphotransferase system, phosphocarrier protein HPr" /codon_start=1 /transl_table=11 /product="Phosphotransferase system, phosphocarrier protein HPr" /protein_id="ZP_05429704.1" /db_xref="GI:256004728" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR005698" /translation="MVEKTVVITNPEGLHARPAALFVQTAGKFTSNVWIKVGKTKVNA KSIMGLISLAVAQGTEVVIGAEGEDEEKAVEELIDLVTTGFTED" misc_feature 40965..>41141 /locus_tag="ClothDRAFT_1565" /note="Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367" /db_xref="CDD:29444" misc_feature 40965..40976 /locus_tag="ClothDRAFT_1565" /note="dimerization domain swap beta strand; other site" /db_xref="CDD:29444" misc_feature order(40992..40994,40998..41003,41007..41012,41022..41024, 41031..41033,41085..41096,41103..41108) /locus_tag="ClothDRAFT_1565" /note="regulatory protein interface; other site" /db_xref="CDD:29444" misc_feature 40995..40997 /locus_tag="ClothDRAFT_1565" /note="active site" /db_xref="CDD:29444" misc_feature 41088..41090 /locus_tag="ClothDRAFT_1565" /note="regulatory phosphorylation site; other site" /db_xref="CDD:29444" gene 41410..41745 /locus_tag="ClothDRAFT_1566" CDS 41410..41745 /locus_tag="ClothDRAFT_1566" /inference="protein motif:TFAM:TIGR02886" /note="TIGRFAM: anti-sigma F factor antagonist; anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: glo:Glov_2101 anti-sigma-factor antagonist" /codon_start=1 /transl_table=11 /product="anti-sigma-factor antagonist" /protein_id="ZP_05429705.1" /db_xref="GI:256004729" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /translation="MNIKLTNRGNTLVAVLNGELDHHTAEYIRQKLDAEMMKSTTKNM VLDFSKVTFMDSSGIGVIMGRYKNIRKLNGKMSLAGINDKIKRIFEMSGLLKLMPAYD SIDEAINKM" misc_feature 41416..41715 /locus_tag="ClothDRAFT_1566" /note="Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043" /db_xref="CDD:132914" misc_feature order(41464..41466,41470..41478,41494..41496,41566..41568, 41572..41580,41584..41592,41599..41604,41668..41670, 41680..41685,41689..41691) /locus_tag="ClothDRAFT_1566" /note="anti sigma factor interaction site; other site" /db_xref="CDD:132914" misc_feature 41575..41577 /locus_tag="ClothDRAFT_1566" /note="regulatory phosphorylation site; other site" /db_xref="CDD:132914" gene 41759..42208 /locus_tag="ClothDRAFT_1567" CDS 41759..42208 /locus_tag="ClothDRAFT_1567" /EC_number="2.7.11.1" /inference="protein motif:TFAM:TIGR01925" /note="KEGG: dat:HRM2_16560 RsbW2; TIGRFAM: anti-sigma F factor; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein" /codon_start=1 /transl_table=11 /product="anti-sigma regulatory factor, serine/threonine protein kinase" /protein_id="ZP_05429706.1" /db_xref="GI:256004730" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /translation="MNPINEVRLEFVSKSSNESFARVVAAAFVSQIDPNLEELADVKT AVSEAVTNAIIHGYENEPGFVKMTLKLYEDAVEISVTDEGKGIEDIEKARQPMYTSRP DMERSGMGFTVMESFMDRVDVVSEVGKGTTVTMFKTFNSVRGRKNTP" misc_feature 41882..42163 /locus_tag="ClothDRAFT_1567" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(41900..41902,41912..41914,41921..41923,41996..41998, 42002..42004,42008..42010,42014..42019,42080..42091, 42125..42127,42131..42133,42146..42151,42155..42157) /locus_tag="ClothDRAFT_1567" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature 41912..41914 /locus_tag="ClothDRAFT_1567" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature order(42008..42010,42014..42016,42080..42082,42086..42088) /locus_tag="ClothDRAFT_1567" /note="G-X-G motif; other site" /db_xref="CDD:28956" gene 42239..42985 /locus_tag="ClothDRAFT_1568" CDS 42239..42985 /locus_tag="ClothDRAFT_1568" /inference="protein motif:TFAM:TIGR02885" /note="TIGRFAM: RNA polymerase sigma-F factor; RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: amf:AMF_363 RNA polymerase sigma factor (RpoD)" /codon_start=1 /transl_table=11 /product="RNA polymerase, sigma 28 subunit, SigF" /protein_id="ZP_05429707.1" /db_xref="GI:256004731" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /translation="MNMDELHEKETLELIAAAKAGDKDAQSLLVEKNVGLVWSIVRRF QNRGYEAEDIFQIGCIGLIKAINKFDCSYDVKFSTYAVPMIIGEIKRFIRDDGMIKVS RSLKELANKARITKEIMSKELGREPTVGEISEQLGIPVEEVVMAMEASCTPESLYSTL GEGDNSSTLLIDKIANESENQEVDIVDRIDLRKVLDTLKPREKQIIVLRYFKEKTQVQ IAKMLGISQVQVSRIEKKILEEIRKKIKYN" misc_feature 42278..42931 /locus_tag="ClothDRAFT_1568" /note="RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885" /db_xref="CDD:131931" misc_feature 42323..42523 /locus_tag="ClothDRAFT_1568" /note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542" /db_xref="CDD:146937" misc_feature 42557..42796 /locus_tag="ClothDRAFT_1568" /note="Sigma-70 region 3; Region: Sigma70_r3; pfam04539" /db_xref="CDD:146934" misc_feature 42800..42931 /locus_tag="ClothDRAFT_1568" /note="Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171" /db_xref="CDD:100119" misc_feature order(42833..42835,42863..42865,42881..42886,42914..42916, 42920..42925,42929..42931) /locus_tag="ClothDRAFT_1568" /note="DNA binding residues" /db_xref="CDD:100119" gene 43168..43356 /locus_tag="ClothDRAFT_1569" CDS 43168..43356 /locus_tag="ClothDRAFT_1569" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429708.1" /db_xref="GI:256004732" /translation="MTEVLRRYKMILIILGLSLVIAFLTFAIFVQKPEKVPSRGIFVF ENTTDEKSFIKVLTEKTL" sig_peptide 43168..43251 /locus_tag="ClothDRAFT_1569" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.923) with cleavage site probability 0.619 at residue 28" gene 43376..43819 /locus_tag="ClothDRAFT_1570" CDS 43376..43819 /locus_tag="ClothDRAFT_1570" /inference="protein motif:TFAM:TIGR02838" /note="TIGRFAM: stage V sporulation protein AC; PFAM: SpoVA protein" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AC" /protein_id="ZP_05429709.1" /db_xref="GI:256004733" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /translation="MQKTMTNKEYQAYVEKKTPNSKTGRNVLRAFLIGGLICTIGQFI TNVLKMMGYGQEQVSSIVSLIMIFIGALLTGLDIYDDIGRYAGAGSIVPITGFANSIV SPAIEFKSEGYVMGVGARMFVVAGPVLVYGISTSIVAGIIYFLLK" misc_feature 43397..43816 /locus_tag="ClothDRAFT_1570" /note="SpoVA protein; Region: SpoVA; cl04298" /db_xref="CDD:155995" gene 43878..44900 /locus_tag="ClothDRAFT_1571" CDS 43878..44900 /locus_tag="ClothDRAFT_1571" /inference="protein motif:TFAM:TIGR02845" /note="TIGRFAM: stage V sporulation protein AD; PFAM: Stage V sporulation AD family protein" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD" /protein_id="ZP_05429710.1" /db_xref="GI:256004734" /db_xref="InterPro:IPR010894" /translation="MASKRLGKQTVMLQNPPRITSTASIVGPKEGKGPLRLFFDNIIE DEMWGEKSWEKAESKLIRETFSKVLQKGNKTSQEIDYVISGDLLNQCIAANFGLRESD VPFFGVYGACSTIAESMSIGAMLVDGGFADNVVCITSSHFCSAEKQFRFPLELGTQRP PSAQWTVTGSGGVLISNDGSGPYITHITTGKIVDMGIKDANNMGAAMAPAAVDTIVTH FKDTGFTPESYDLILTGDLGAIGREICVELTREQGFNIENIYNDCGLMIYDREKQDTH AGGSGCGCAATVFAGFVYKKLMDGTLKNVLFVATGALLSPVSTQQGESIPSIAHAISI TTSPER" misc_feature 43881..44879 /locus_tag="ClothDRAFT_1571" /note="stage V sporulation protein AD; Validated; Region: PRK08304" /db_xref="CDD:181369" gene 44944..45315 /locus_tag="ClothDRAFT_1572" CDS 44944..45315 /locus_tag="ClothDRAFT_1572" /inference="protein motif:TFAM:TIGR02839" /note="TIGRFAM: stage V sporulation protein AE; PFAM: SpoVA protein" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AE" /protein_id="ZP_05429711.1" /db_xref="GI:256004735" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /translation="MDNTIMTYISAFIVGGVICAVGQILIDKTKLTSARILVLFVSAG AVLTALGVYQKLVDIGGAGATIPLTGFGYNLVTGTFKEVDKLGILGAFTGGVRAAAAG IAAAIFFGYLMSVAFTPKAKR" misc_feature 44965..45303 /locus_tag="ClothDRAFT_1572" /note="SpoVA protein; Region: SpoVA; cl04298" /db_xref="CDD:155995" gene 45392..45955 /locus_tag="ClothDRAFT_1573" CDS 45392..45955 /locus_tag="ClothDRAFT_1573" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429712.1" /db_xref="GI:256004736" /translation="MNKRKVIIVTDGDMAAKAAVEIAALNIGGECISYSAGNPTVLTG QQIVELVKAAEKDPVVVMVDDKGYKGKGAGEAAMEVLLNNDDIEVLGVVAVSSDGKDC NGIKLTCSVTREGKVIEGSVNKKGIATRNGKICGDTLSILRGRKDLVIVGIGDPGKMD FYDSIEKGAPITTKALQEVLKRSAARH" gene 46029..46493 /locus_tag="ClothDRAFT_1574" CDS 46029..46493 /locus_tag="ClothDRAFT_1574" /inference="protein motif:PFAM:PF04509" /note="PFAM: CheC domain protein; KEGG: sat:SYN_00961 putative inhibitor of MCP methylation" /codon_start=1 /transl_table=11 /product="CheC domain protein" /protein_id="ZP_05429713.1" /db_xref="GI:256004737" /db_xref="InterPro:IPR007597" /translation="MNVEYINPFIEASRAVLKQIAGIDVKLGSISLKNSPYASDNIVI LVGLTGKIRGQAIFSMNKNVALTVASGMMGGLNLTELDEMSKSALSELTNMILGNTAT LLYNRGVGVEITPPSFLMGENMQISPSKMKTICIPLLLGEDKKIELDISVVD" misc_feature 46029..46484 /locus_tag="ClothDRAFT_1574" /note="Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406" /db_xref="CDD:31596" gene 46623..47117 /locus_tag="ClothDRAFT_1575" CDS 46623..47117 /locus_tag="ClothDRAFT_1575" /inference="protein motif:TFAM:TIGR00185" /note="TIGRFAM: RNA methyltransferase, TrmH family, group 2; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: glo:Glov_2088 tRNA/rRNA methyltransferase (SpoU)" /codon_start=1 /transl_table=11 /product="RNA methyltransferase, TrmH family, group 2" /protein_id="ZP_05429714.1" /db_xref="GI:256004738" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004440" /translation="MAINVVLVEPEIPQNTGNIARTCAAVGANLHLVKPLGFSVEDRY LKRAGLDYWDKVNIKYYDSFSELRDKYKEHIFYYSTTKAQKLYTDVKYPDDCFIVFGK ETAGLPEELLVENKEWCIRIPMRDDIRSLNLSNSVAIIVYEALRQNNFAGLVPYGKLT KYTW" misc_feature 46623..47084 /locus_tag="ClothDRAFT_1575" /note="SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362" /db_xref="CDD:185941" gene 47453..48970 /locus_tag="ClothDRAFT_1576" CDS 47453..48970 /locus_tag="ClothDRAFT_1576" /inference="protein motif:TFAM:TIGR00254" /note="KEGG: gme:Gmet_0018 metal dependent phosphohydrolase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; metal-dependent phosphohydrolase HD sub domain; SMART: GGDEF domain containing protein; metal-dependent phosphohydrolase HD region" /codon_start=1 /transl_table=11 /product="diguanylate cyclase and metal dependent phosphohydrolase" /protein_id="ZP_05429715.1" /db_xref="GI:256004739" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /translation="MNKHVSLLRKRYVDLRDTYLGSELKKVELLFYISVSIALGLIQY KLLNYENTYNIRAYISHIQSCIVILMAFRFGYVGLATAVVLVLAETIFIIEEYLVSFD KYLLLGLTLKFFTIFVTSFIAVLTNRQQIQKKRLERMAITDELTGAYNQRFFHMVLES ELEKAKNNNGSVSLIMIDIDNFKMYNDIYGRDFGDNILRTTATILSEILDEGSYLCRY GGDEFAVITTNTRLDNLEDMANNLRREFERLKQKYYKHKLYEKVTLSIGLSEYPNMSR DKNELIYQADTALYHAKNLGKDKVHLYQDALMQIRKNISSDHQQLIGIFKGLLSTISA KDKYTHGHCERVAAYAVLIAEAMGLSAKEISTIQCAALLHDIGKIEMPRHILNKKEEL TEEEIKYLRQHPIYSENILEPLADMDKLTDYVRHHHERYDGKGYPDGLKGKEISLGAR ILCVADSFDAMVSDRPYSKSMSKEDAFKELEKNAGTQFDPEIVEIFIKAMKSYAA" misc_feature 47876..48355 /locus_tag="ClothDRAFT_1576" /note="Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949" /db_xref="CDD:143635" misc_feature order(47984..47986,48113..48115) /locus_tag="ClothDRAFT_1576" /note="metal-binding site" /db_xref="CDD:143635" misc_feature order(47999..48001,48008..48013,48023..48025,48035..48037, 48101..48103,48107..48118) /locus_tag="ClothDRAFT_1576" /note="active site" /db_xref="CDD:143635" misc_feature order(48089..48091,48173..48175) /locus_tag="ClothDRAFT_1576" /note="I-site; other site" /db_xref="CDD:143635" misc_feature 48464..48892 /locus_tag="ClothDRAFT_1576" /note="Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077" /db_xref="CDD:28958" misc_feature order(48476..48478,48572..48577,48818..48820) /locus_tag="ClothDRAFT_1576" /note="Zn2+ binding site; other site" /db_xref="CDD:28958" misc_feature 48575..48577 /locus_tag="ClothDRAFT_1576" /note="Mg2+ binding site; other site" /db_xref="CDD:28958" gene 49175..50209 /locus_tag="ClothDRAFT_1577" CDS 49175..50209 /locus_tag="ClothDRAFT_1577" /EC_number="2.3.1.41" /inference="protein motif:PRIAM:2.3.1.41" /note="PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: mca:MCA2003 3-oxoacyl-(acyl carrier protein) synthase III" /codon_start=1 /transl_table=11 /product="Beta-ketoacyl-acyl-carrier-protein synthase I" /protein_id="ZP_05429716.1" /db_xref="GI:256004740" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /translation="MTELFYFPKRKKKTIRRFCKILSTDSYIPEKVVENEEIIEKYHP SFKNEVIVKTIGVERRHIAEKDEDDSDILAKSARGCLEKYGILPDDLSRIIVNKFVGD NFLPMTASRLQGKIGSKTAVHAFDIDGGISSFLYSMDAASRFINSGDEYILISSGGVI SKFVSKADPRVAFLFGDASASVLLGHSEERHILASYFYSNCHYYDMFVMLSPLSLAKF SREELSTAVWDLYKMENWKTAESFYREAVREVSKNLLEESGLTMKDIDLVLVTENNIK IWELTLETLGVNADKSISLIREYGNTMSAMLPLLIDHGFRTGRIEKGMNIMMISHGEG FSGGGLVYRV" misc_feature 49223..50206 /locus_tag="ClothDRAFT_1577" /note="3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332" /db_xref="CDD:30680" misc_feature 49232..50200 /locus_tag="ClothDRAFT_1577" /note="Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830" /db_xref="CDD:29417" misc_feature order(49469..49471,49475..49477,49502..49504,49511..49513, 49535..49540,49544..49558,49580..49582,49589..49594, 49601..49606,49658..49660,49763..49780,49796..49801, 50174..50176) /locus_tag="ClothDRAFT_1577" /note="dimer interface; other site" /db_xref="CDD:29417" misc_feature order(49565..49567,49985..49987,50075..50077) /locus_tag="ClothDRAFT_1577" /note="active site" /db_xref="CDD:29417" misc_feature 49994..49996 /locus_tag="ClothDRAFT_1577" /note="CoA binding pocket; other site" /db_xref="CDD:29417" gene 50322..50567 /locus_tag="ClothDRAFT_1578" CDS 50322..50567 /locus_tag="ClothDRAFT_1578" /inference="similar to AA sequence:KEGG:Caul_2519" /note="KEGG: cak:Caul_2519 acyl carrier protein" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="ZP_05429717.1" /db_xref="GI:256004741" /translation="MNYDEIYDKAKQMIAEYLRVDENEITPKTNLVDDLCADSIALVE LGFRFSETFSVPMMESKPDMFIMDNIVRFIMEKTGDK" misc_feature 50331..>50486 /locus_tag="ClothDRAFT_1578" /note="Phosphopantetheine attachment site; Region: PP-binding; cl09936" /db_xref="CDD:186876" gene 50709..51746 /locus_tag="ClothDRAFT_1579" CDS 50709..51746 /locus_tag="ClothDRAFT_1579" /EC_number="2.3.1.180" /inference="protein motif:PRIAM:2.3.1.180" /note="PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: xca:xccb100_3342 3-oxoacyl-(acyl carrier protein) synthase III" /codon_start=1 /transl_table=11 /product="Beta-ketoacyl-acyl-carrier-protein synthase III" /protein_id="ZP_05429718.1" /db_xref="GI:256004742" /db_xref="InterPro:IPR000408" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /translation="MNNDIRFPEIKPLKIERYAKIVSTGVGLPERVVTNQDIIDEYDI IATDRAVRYSVGIVERRWVTDEKLEDLVAMAISQCLERAGLDIDSVDRIIYSRLLGDY QVPATSIGALRKLGAKVGIPAFDMTCACSGFMHALDLAIRYIDSGDDYIIILGGGITS QGIQIWKQPNQKTIFLFGDAVVAVLIGYSEVKHFLASYLMTNHLLYDNAFIPFGTTLF KNENVKIEPELFNMNVINGDLILESSVEYCRMITDKLLAETNLTLDDIDFFITSDQST KIWEAQVKELGIPFEKSLSLFYKYANTVAAMSPLILHELITSGRLKRGDLVMMHAHGA GASSGGMIFRY" misc_feature 50757..51689 /locus_tag="ClothDRAFT_1579" /note="3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332" /db_xref="CDD:30680" misc_feature 50760..51689 /locus_tag="ClothDRAFT_1579" /note="Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830" /db_xref="CDD:29417" misc_feature order(51000..51002,51006..51008,51033..51035,51042..51044, 51069..51089,51111..51113,51120..51125,51132..51137, 51192..51194,51303..51320,51336..51341) /locus_tag="ClothDRAFT_1579" /note="dimer interface; other site" /db_xref="CDD:29417" misc_feature order(51096..51098,51522..51524,51612..51614) /locus_tag="ClothDRAFT_1579" /note="active site" /db_xref="CDD:29417" misc_feature 51531..51533 /locus_tag="ClothDRAFT_1579" /note="CoA binding pocket; other site" /db_xref="CDD:29417" gene 51785..53269 /locus_tag="ClothDRAFT_1580" CDS 51785..53269 /locus_tag="ClothDRAFT_1580" /inference="protein motif:PFAM:PF00501" /note="PFAM: AMP-dependent synthetase and ligase; KEGG: dal:Dalk_4880 AMP-dependent synthetase and ligase" /codon_start=1 /transl_table=11 /product="AMP-dependent synthetase and ligase" /protein_id="ZP_05429719.1" /db_xref="GI:256004743" /db_xref="InterPro:IPR000873" /translation="MNYCNWLFDTKDKDLEREIIIDWETGKRLTFKGLQTEVVRLANF LKSKGYVPGTVIATHLYNGIEAAVAFLAAEYIGCVVCLVDPLFKADEVPYYVEDSGAK CLITHLEKDEIAGKLPSEVDVINVREVQEVCESDEFEKSLEIYDFEENELALLLYTSG STSTPKGVMLTTGCCHTFLRKNHQSMYRYDPDDRILCFVPFSHGFGSISVLIPALAYK AGIVFQKTFHPAKVAEAVIKENITHMLGVPTHYRQLLRYEPFINNLGKLKAAFCSAAP ISCEVARQWYEKTGIYLDEGYGMSEATTLITTRMSRLPSTSGDVGHPPEGIISVDIVD DNDRVVENGTIGEIRVTGQGLMLGYLNRPKETAERLRNGYLYTGDLGYKNPDGSLVVC GRKTEFINVAGLKISPVEVETALNSHSDVIDSAVVGVTDEVYGEVVKAFVIKKQDSNL TERELIKYVSDKVANFKVPKYVVFVDEFPRNNVGKVDKKALKNM" misc_feature 51800..53266 /locus_tag="ClothDRAFT_1580" /note="Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318" /db_xref="CDD:30666" misc_feature 51866..53266 /locus_tag="ClothDRAFT_1580" /note="Acyl-protein synthetase, LuxE; Region: LuxE; cl10450" /db_xref="CDD:186997" gene 53290..54261 /locus_tag="ClothDRAFT_1581" CDS 53290..54261 /locus_tag="ClothDRAFT_1581" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429720.1" /db_xref="GI:256004744" /translation="MNEASSKFVDNIAIEKLLNEKLLRVSHRPKNLFYDDEKVFDDLC KCETDMSKVKLAEGDKNLKRFEFPSFLKTEEYIENNTVYLYYHPAKDPVCNILLLHGL YDDNMLNYGFLTRMLNELKFNVFLMELPFHFNRKPAESFFSGEYFISADLLRARNAFI QSIYDIEASRNLIGNINTLPCLLVGFSMGGCISFRYHMLRDSFKGTFLINPVTDMLLL VWDNPLLVKIKKDLEDSGVGKEQVMDVFRIIDPCENINTRFNTDNIAVVYSIYDQIVG EEKNAIFVEKIKKAGLKKILEYHAGHLNILRVPKLSNDIYEFFMSCL" misc_feature 53479..>53979 /locus_tag="ClothDRAFT_1581" /note="Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267" /db_xref="CDD:32448" gene 54310..62574 /locus_tag="ClothDRAFT_1582" CDS 54310..62574 /locus_tag="ClothDRAFT_1582" /inference="protein motif:PFAM:PF02801" /note="PFAM: Beta-ketoacyl synthase ; Acyl transferase; KR domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; short-chain dehydrogenase/reductase SDR; KEGG: dat:HRM2_31930 predicted polyketide synthase" /codon_start=1 /transl_table=11 /product="Beta-ketoacyl synthase" /protein_id="ZP_05429721.1" /db_xref="GI:256004745" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR006163" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR014043" /translation="MKNYFYPEERIAIVGMGALLPDANNVDSFWNNILSKKVSIKELP ESILNPDIYYDRDAFGKINKNDKTYTRMVAKVDVDDYPSLTRKFKIPPAVAEHMDPNQ HVAIYCVDQALQSLANSNINRERTAVIMNIGAPGIRYNNIIRRTYYAKIEHYLRNNPK LNESLKKEELDEVLNGLSDMALAGTIPITEDSAPGMLQSITASRISNLFDFYGPAYTI DAACASSLAAVICGITGLLRKDYDVLITGGVDVTLDESPFVVFSAINALSPTGSYPFD SRANGFVIGLGGGVLILKRLEDALRDNDRIYALISGFGQGSDGKGKYIAAPNEEGQVR VLKSTLEMMGYPADTIEYIEAHGTGTSVGDVVEIKALKKAFDAMGVTKKNFCGISSVK SNIGHLRYAAGSPGLIKAAMAIYNKILPPTANIEKINPKLEIEDSPFYILTEKKPWRE NPSHPRRANVSAYGFGGADYCLALEEFRPEFIRKTYAFSKPYEDAKNADNAQNALSVT QEVVMFSGSSIEEINEAYGLFVGENSENTDFGQAVFYNNSSVSAKKEYRLAICASSMD ELKEKYGIFEQFVKEGKTENLQALNVKGIYFGKGEAVAPDKVAWMFPGQASQYPNMLK DIYESYPQVAALYMQADAYWKSKYGDKISSFVFGDDEEHLQTVLKDTKNTHPAMFLSN IAMFRLLSESGVRADYMIGHSLGEVTALYASGMLDLKSALRLIGERGFAFDGIPKEDR GMMMSIKADKPKVEELIKESGLKVYVANLNSPEQTVIGGREEQIERMAQILEQNKITY TKLNVSHAFHTELVANAAERYYEKIKDLSFDVPKAHVMACHKVDFYPGDRENMALLPS MLKEQVVSSVNFTESVLKLYEKGVRVFVEAGPSSVLTNLVKNILQGKDVKVIASNNKR KNAVDAYKQALAELFACGVDVTVLPSQKAPGHSENTVRVAEKAVEESSGFKAEIKIPV QANAEPSKPSGKESLVYSGVSAGLPGTFKKAFSDDNFDLLFEGKNLIERLTDDEAGSI LDLNITRLLKTEAETTFKQLTSINEVIQLAGKLGKIDMLADYQIDEKALRQMTMTVCA GVAAGYEALKDAGIPLIRERIKTSGGSYLPGRLVLPEHMQDDTGVIFANGFFPIETWV DEVSKYIASKFARKTRNDLIDFYESVISKVSDYSVKKYLTDWFNLHYSRLMYNSGEEE IYKFNHEFLYSFSLQANNRLAQFIGAMGPNLFLNAACSSTITAVTVAEGLIRAGHARR MIVIGADNVTSKSILPWSAASFLSTGVLTTSSDLFEAAVPFDRRRSGMILGAGAVGLV IEKESDVAERGMNGICRILGTHAFNTAGHPARIDSNRFAVEFDKFMTRMEQEYGFARK DIAKRTVYYSHETFSPRKGGCACAEKTALESTFGDNFRDVKVINTKGMTGHTLGASIE EAVAAKALQYQKIPPVVNFKEPDPDLEGLNLSSGGSYSFDYVIRMVAGYGSQGNYHLL QKIAEGDRRILDEEAYQRWLDRITGSKGAKLAKCGRILVAEGAQKEIQAREIEAPTGE VPFSSGTAAVLDRKPDYAASFATPDSTHIDKNKIADNAIVDEILDIYSEITGYPKEML DLNMEIEADLGIDTVKQATILSMISEKFNIPQEDSVKLSNYPTIGHVVNMVQSKYAKE DNISKGSTVPYAKSDVFPGNINVAGSEAGNVQEEVLKVISEITKYPVEMLDMNMEMEA DLGIDTVKQATIFSILGEKFNLGDKNANISQYKTIGSIVDLVSQSAGKGLKETADLGG ETYSSNVVNNIVNFEKPADQPQSGIQAGKFGSKNAKGLSGNNEKNIEEEVLEIISTIT KYPAEMLEKDMEMEADLGIDTVKQATIFSLLSEKFDVGKNEKINISEYKTIGSIIELV KGSFKKEEPSFEDAKGEVAAVESIDDEDVNIQKDLCLQIPVFVEKEAKGEDFDLKDKK IWVMGDNDGQVRKVAQYFAELSAGVEEFVFEYKGDAAKLEKDVAEFINKNHKADAIVD CTHLRTDVDFEKLTEEEQEKMLFLSSEARFIFYKTLAQKVSMPEIRIVCAISMDGCHG YSPKEQIVADPFYSALSGLYKGLGKEWGKSTVRIVDLGPDKGRILENEDLSILAKELK NKCDDYEIGYHDGKRGVIKLKNLDRGSFKQMNIPENAHFVITGGGSGITSEITKGLSR KFKGKYTIIGRTELPDDSELIPDDETSANDIKLEIQKRLERTNKKVTPVMVQKEYDKL IKSNSIKKLLESIKEDGNSATYLACDVRNYEELKKALDKAVQENGPVHVLIHGAGVER SRLLSQKEREEFNDVFSVKAKGLCNLYRILDKKALKIAMAFSSISGRFGNGAQIDYCA ANSFLSGFMAMLATKYKDIYSLSLAWSGWKDLGMAWRNEFVKTNSEEMGLHLIEPERG TNEFINILTGNIDSKEVVISRGLGVLDDNMVVGESLDDKPMIDWITKKNGRIEKVFKV VSVKRDAIFDHHRLGTVPLAPAVSFMELAAEAFSMISGEKTQFCFRNMNMDKPLKLFH EEPREVIALLDQKEGTDGVDVKLYTYLNSRFGISKLIGLNSMNVSGKLGEYRHLLDLM KIESEPMEQDFTGKALKDLLKRNPNSINLGTLFIDAIKENHIFRRNQNGAVFSMLLPE EELINEKYHLDKLLINPAFADSVFQICGVHSLYNSVDVYLPWQIEEFGVVKAPKERIR YKAYCALKHEDDEVKVYDVIMLDENNEVCYYAKSVKMRLIHS" misc_feature 54334..55731 /locus_tag="ClothDRAFT_1582" /note="polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833" /db_xref="CDD:29420" misc_feature 54340..55740 /locus_tag="ClothDRAFT_1582" /note="Beta-ketoacyl synthase; Region: PKS_KS; smart00825" /db_xref="CDD:129058" misc_feature order(54973..54975,55375..55377,55498..55500) /locus_tag="ClothDRAFT_1582" /note="active site" /db_xref="CDD:29420" misc_feature 56128..57069 /locus_tag="ClothDRAFT_1582" /note="Acyl transferase domain; Region: Acyl_transf_1; cl08282" /db_xref="CDD:186816" misc_feature 56128..57006 /locus_tag="ClothDRAFT_1582" /note="malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128" /db_xref="CDD:161724" misc_feature 57391..58779 /locus_tag="ClothDRAFT_1582" /note="3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304" /db_xref="CDD:30652" misc_feature 57517..58698 /locus_tag="ClothDRAFT_1582" /note="Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938" /db_xref="CDD:158792" misc_feature order(58030..58032,58594..58596) /locus_tag="ClothDRAFT_1582" /note="active site" /db_xref="CDD:73194" misc_feature <58966..61845 /locus_tag="ClothDRAFT_1582" /note="polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813" /db_xref="CDD:163029" misc_feature 59071..59307 /locus_tag="ClothDRAFT_1582" /note="Phosphopantetheine attachment site; Region: PP-binding; cl09936" /db_xref="CDD:186876" misc_feature <61096..61494 /locus_tag="ClothDRAFT_1582" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" gene 62571..63296 /locus_tag="ClothDRAFT_1583" CDS 62571..63296 /locus_tag="ClothDRAFT_1583" /inference="protein motif:PFAM:PF01648" /note="PFAM: 4'-phosphopantetheinyl transferase; KEGG: dps:DP0914 hypothetical protein" /codon_start=1 /transl_table=11 /product="4'-phosphopantetheinyl transferase" /protein_id="ZP_05429722.1" /db_xref="GI:256004746" /db_xref="InterPro:IPR008278" /translation="MITNMIAEGKDTLRLANLFLERYAAEHRVFYHIVDMREIARKIK VNEIDVLSVLSERELAHLKNLRNPKNRLQWISGRYAVKSAIFKYKAKERSIIDPRCLD VLKGADSAPFILQYSDMGVSITHAFPYCIGMVSDRAVGIDMEKIFLPEDALIKYFFSE REEKILKSFGNTDEYCVQSTILWTRKEALSKLFRLGMRMDFKKLDTLEDEVVFQETNR ARLFSFICNNYCISLALPGFNKD" misc_feature 62721..>63200 /locus_tag="ClothDRAFT_1583" /note="Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091" /db_xref="CDD:32274" misc_feature 62985..63155 /locus_tag="ClothDRAFT_1583" /note="4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500" /db_xref="CDD:186039" gene 63560..64570 /locus_tag="ClothDRAFT_1584" CDS 63560..64570 /locus_tag="ClothDRAFT_1584" /EC_number="1.2.1.12" /inference="protein motif:TFAM:TIGR01534" /note="KEGG: glyceraldehyde 3-phosphate dehydrogenase; K00134 glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase, type I" /protein_id="ZP_05429723.1" /db_xref="GI:256004747" /db_xref="InterPro:IPR000173" /db_xref="InterPro:IPR006424" /translation="MAVKIGINGFGRIGRLVFRASLNNPNVEVVGINDPFIDLEYMQY MLKYDTVHGQFKGEISQDNGKLVVNGRKISVYGFTDPAEIPWSECGAEYIVESTGVFT TTEKASAHFKGGAKKVVISAPSADAPMFVMGVNHDKYTKDMNVVSNASCTTNCLAPLA KVIHENFGIVEGLMTTVHATTATQKTVDGPSKKDWRGGRAAAGNIIPSSTGAAKAVGK VIPELNGKLTGMAFRVPTLDVSVVDLTCRLEKPATYDEIKAAVKKASENELKGILGYT EDAVVSSDFIGDPRTSIFDAEAGISLNSNFVKLVAWYDNEWGYSNKVVDLIVHMASVD AK" misc_feature 63560..64561 /locus_tag="ClothDRAFT_1584" /note="glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023" /db_xref="CDD:173322" misc_feature 63566..64012 /locus_tag="ClothDRAFT_1584" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature 64025..64498 /locus_tag="ClothDRAFT_1584" /note="Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800" /db_xref="CDD:145777" gene 64904..66097 /locus_tag="ClothDRAFT_1585" CDS 64904..66097 /locus_tag="ClothDRAFT_1585" /EC_number="2.7.2.3" /inference="protein motif:PRIAM:2.7.2.3" /note="PFAM: phosphoglycerate kinase; KEGG: pca:Pcar_1332 phosphoglycerate kinase" /codon_start=1 /transl_table=11 /product="Phosphoglycerate kinase" /protein_id="ZP_05429724.1" /db_xref="GI:256004748" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015911" /translation="MAMMNKKTIEDIDVKGKKVIVRVDFNVPLDENRKITDDKRIVGA LPTIKYLVEHGAKTILVSHLGRPKEGFEEKYSMAPTAVRLGELLGKEVIMAKDVIGPD AKAKAAALKEGEVLMLENVRFHKEETKNDPAFAKELASMAEIYVNDAFGTAHRAHAST AGLADYLPAVCGYLIQKEIEVMGKALSNPERPFVAILGGAKVSDKIGVIENLIDKVDT LIIGGGMAYTFFKAKGYSIGTSLCEDDKVELAKSLMDKAEKKGVKLLLPVDNVVGKEF SNDTERKTVPSDQIPDGWMGMDIGEETIKLYSEAIKNAKTVVWNGPMGVFEFSNFANG TREVARAVAESGAISIIGGGDSAAAIEQLGFADKITHISTGGGASLEFLEGKVLPGID VLMDK" misc_feature 64928..66085 /locus_tag="ClothDRAFT_1585" /note="Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318" /db_xref="CDD:29400" misc_feature order(64973..64975,64979..64981,65021..65023,65090..65092, 65267..65269) /locus_tag="ClothDRAFT_1585" /note="substrate binding site; other site" /db_xref="CDD:29400" misc_feature order(65459..65470,66017..66025) /locus_tag="ClothDRAFT_1585" /note="hinge regions; other site" /db_xref="CDD:29400" misc_feature order(65573..65575,65789..65791,65861..65863,65867..65869, 65873..65884,65963..65971) /locus_tag="ClothDRAFT_1585" /note="ADP binding site; other site" /db_xref="CDD:29400" misc_feature 65966..65968 /locus_tag="ClothDRAFT_1585" /note="catalytic site; other site" /db_xref="CDD:29400" gene 66112..66867 /locus_tag="ClothDRAFT_1586" CDS 66112..66867 /locus_tag="ClothDRAFT_1586" /inference="protein motif:TFAM:TIGR00419" /note="TIGRFAM: triosephosphate isomerase; PFAM: triosephosphate isomerase; KEGG: afw:Anae109_2280 triose-phosphate isomerase" /codon_start=1 /transl_table=11 /product="triosephosphate isomerase" /protein_id="ZP_05429725.1" /db_xref="GI:256004749" /db_xref="InterPro:IPR000652" /translation="MSRKVIAAGNWKMNKTPKEAVEFVQALKGRVADADTEVVVGVPF VCLPGVVEAAKGSNIKVAAQNMHWEEKGAFTGEVSGPMLAELGVDYVIIGHSERRQYF GETDETVNKKVHAAFKYGLKPIICVGESLTQREQGVTAELVRYQVKIALLGLSAEQVK EAVIAYEPIWAIGTGKTATNEQAEEVCGIIRECIKELYGQDVAEAIRIQYGGSVNAAN AAELFNMPNIDGGLVGGASLKLDDFEKIAKYNK" misc_feature 66127..66855 /locus_tag="ClothDRAFT_1586" /note="Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311" /db_xref="CDD:73362" misc_feature order(66139..66141,66145..66147,66394..66396,66610..66612, 66628..66630,66748..66750,66805..66807,66811..66816) /locus_tag="ClothDRAFT_1586" /note="substrate binding site; other site" /db_xref="CDD:73362" misc_feature order(66139..66141,66148..66150,66241..66249,66253..66255, 66262..66264,66301..66303,66355..66357,66364..66369, 66400..66405) /locus_tag="ClothDRAFT_1586" /note="dimer interface; other site" /db_xref="CDD:73362" misc_feature order(66145..66147,66394..66396,66610..66612) /locus_tag="ClothDRAFT_1586" /note="catalytic triad; other site" /db_xref="CDD:73362" gene 67054..67827 /locus_tag="ClothDRAFT_1587" CDS 67054..67827 /locus_tag="ClothDRAFT_1587" /EC_number="5.4.2.1" /inference="protein motif:PRIAM:5.4.2.1" /note="PFAM: BPG-independent PGAM domain protein; KEGG: ppd:Ppro_3611 phosphoglyceromutase" /codon_start=1 /transl_table=11 /product="Phosphoglycerate mutase" /protein_id="ZP_05429726.1" /db_xref="GI:256004750" /db_xref="InterPro:IPR011258" /translation="MKDKLVMLIILDGYGINPRKEGNAIEAANKPNIDRFMREYPNTI VRTSGMDVGLPDGQMGNSEVGHTNIGAGRIVYQELTRITKSIQDGDFFEKKEFLDAAE NCRKHNSKLHLFGLLSDGGVHSHNTHLYGLLEFAKRQNLKDVYVHCFFDGRDVPPDSA MGYVEELENKIREIGVGEIATVMGRYYAMDRDNRWERVKLAYDAMVLGRGNQAQSAKE AVAESYKRQEFDEFVKPTVIMKKRLSGGYCRGKRLYNIL" misc_feature 67054..>67776 /locus_tag="ClothDRAFT_1587" /note="Sulfatase; Region: Sulfatase; cl10460" /db_xref="CDD:186998" gene 67787..68590 /locus_tag="ClothDRAFT_1588" CDS 67787..68590 /locus_tag="ClothDRAFT_1588" /inference="protein motif:PFAM:PF01676" /note="PFAM: metalloenzyme domain protein; BPG-independent PGAM domain protein; KEGG: gur:Gura_4127 phosphoglyceromutase" /codon_start=1 /transl_table=11 /product="metalloenzyme domain protein" /protein_id="ZP_05429727.1" /db_xref="GI:256004751" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /translation="MATVGENDSIIFFNFRPDRAREITRAFTEVNFSGFEREKGYFPV FFVCMTQYDKTFENVVVAFKPESLENTFGEYISKKGLRQLRIAETEKYAHVTFFFNGG VEAVYEGEDRILINSPKVATYDLKPEMSAYEVTDKVLECINKKEYDVIILNYANPDMV GHTGVFEAAKAAIEAIDECLGKVVPAVLEQNGVVLITADHGNSEQMIDYETGGPFTAH TTNPVPLIVIGLGDVKLREGRLADLAPTMLDILGFEKPKEMTGESLIVK" misc_feature <67790..68584 /locus_tag="ClothDRAFT_1588" /note="Sulfatase; Region: Sulfatase; cl10460" /db_xref="CDD:186998" gene 68928..70565 /locus_tag="ClothDRAFT_1589" CDS 68928..70565 /locus_tag="ClothDRAFT_1589" /inference="protein motif:TFAM:TIGR00254" /note="KEGG: gme:Gmet_2559 metal dependent phosphohydrolase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; metal-dependent phosphohydrolase HD sub domain; SMART: GGDEF domain containing protein; metal-dependent phosphohydrolase HD region" /codon_start=1 /transl_table=11 /product="diguanylate cyclase and metal dependent phosphohydrolase" /protein_id="ZP_05429728.1" /db_xref="GI:256004752" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /translation="MIKGIDNANSCWNDFQHDKKEGWLSWLGISNKESSKLFFIIASL HIIIVMVQASGKLPVGFRAVTGIFEIGISILLSYRFGYIGMSLSLITNGLAAMRLFVI ARQLDMVVASEAGHLTGDLRIITDSAPGLLLNLSAARVAVMIVSIIVAYSYEQERKYI NRLEWLACVDGVTGVYNHRYFQTRLGEEIEKANLRNGSLALVMIDVDNFKKYNDTHGH IAGDRLLTKTAEIFKASARQEDIVCRYGGDEFVILMPDADSKSIISMIQKIRKEFSDF LDTEEFRIHRNEISLSVGYSIYPELARNKDDLIMQADSALYQAKNMGRNNVRIYRDVF EDIKTFFNSNEQQLLGGLRALLGTVSAKDKYTLGHSERVMEYAVRIGKAMGLSSERLR LLKIAALLHDIGKVEIPESVLNKTEPLTPAEMKNLRRHPMYSVDILEPLSSIDMLIDS IKYHHERYDGKGYPTGKKGKEIPLEARILSVADAFDAMLSDRPYRKGMKINEVLAELK NNSGTQFDPETVEAFLSTFDNSDCDSHSISHSIDEAI" misc_feature 69435..69911 /locus_tag="ClothDRAFT_1589" /note="Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949" /db_xref="CDD:143635" misc_feature order(69540..69542,69669..69671) /locus_tag="ClothDRAFT_1589" /note="metal-binding site" /db_xref="CDD:143635" misc_feature order(69555..69557,69564..69569,69579..69581,69591..69593, 69657..69659,69663..69674) /locus_tag="ClothDRAFT_1589" /note="active site" /db_xref="CDD:143635" misc_feature order(69645..69647,69729..69731) /locus_tag="ClothDRAFT_1589" /note="I-site; other site" /db_xref="CDD:143635" misc_feature 70020..70448 /locus_tag="ClothDRAFT_1589" /note="Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077" /db_xref="CDD:28958" misc_feature order(70032..70034,70128..70133,70374..70376) /locus_tag="ClothDRAFT_1589" /note="Zn2+ binding site; other site" /db_xref="CDD:28958" misc_feature 70131..70133 /locus_tag="ClothDRAFT_1589" /note="Mg2+ binding site; other site" /db_xref="CDD:28958" gene 70765..72066 /locus_tag="ClothDRAFT_1590" CDS 70765..72066 /locus_tag="ClothDRAFT_1590" /EC_number="4.2.1.11" /inference="protein motif:TFAM:TIGR01060" /note="KEGG: geo:Geob_3099 phosphopyruvate hydratase; TIGRFAM: enolase; PFAM: enolase" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="ZP_05429729.1" /db_xref="GI:256004753" /db_xref="InterPro:IPR000941" /translation="MKQYLEIESVFAREILDSRGNPTVEVEVIAEGGFVGRAAVPSGA STGAFEAVELRDNDKNRYLGKGVQKAVENVNNIIAPEVEGMNVFDQAAVDNLMISLDG TPNKSKLGANAILGVSLATAKAAAEALGLSLYQYIGGVNAKTLPVPMMNIINGGKHAD NSVNIQEFMIMPVGASSFRHALQMCAEVFHNLKKVLKDKGYSTAVGDEGGFAPNLKTD EEAIQVILEAVEKAGYKPGDDFRLAIDAASTEMYQEDGTYLFWKSGVKKTKEEMINYW EELVNKYPIISLEDGVAEEDWEGWKMLTERLGKRIQLVGDDLFVTNTTRLKKGIELGV ANSILIKVNQIGTLTETLDAIEMANRAGYTAVVSHRSGETEDATIADIAVATNAGQIK TGAPSRTDRVAKYNQLLRIEEEIGAVSRYPGLDAWFNLKKK" misc_feature 70780..72057 /locus_tag="ClothDRAFT_1590" /note="enolase; Provisional; Region: eno; PRK00077" /db_xref="CDD:178845" misc_feature 70789..72006 /locus_tag="ClothDRAFT_1590" /note="Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313" /db_xref="CDD:48188" misc_feature order(70795..70797,70801..70827,70837..70839,70873..70875, 71239..71247,71308..71313,71320..71325,71332..71337, 71374..71379,71398..71400,71404..71406,71881..71889, 71956..71964,71968..71973,71980..71982,71989..71994, 72001..72003) /locus_tag="ClothDRAFT_1590" /note="dimer interface; other site" /db_xref="CDD:48188" misc_feature order(70897..70899,71497..71499,71629..71631,71710..71712) /locus_tag="ClothDRAFT_1590" /note="metal-binding site" /db_xref="CDD:48188" misc_feature order(71236..71238,71386..71388,71785..71787,71869..71877, 71938..71940) /locus_tag="ClothDRAFT_1590" /note="substrate binding pocket; other site" /db_xref="CDD:48188" gene 72242..72481 /locus_tag="ClothDRAFT_1591" CDS 72242..72481 /locus_tag="ClothDRAFT_1591" /inference="protein motif:TFAM:TIGR00810" /note="TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit; KEGG: afw:Anae109_2279 preprotein translocase, SecG subunit" /codon_start=1 /transl_table=11 /product="preprotein translocase, SecG subunit" /protein_id="ZP_05429730.1" /db_xref="GI:256004754" /db_xref="InterPro:IPR004692" /translation="MQIAVTILHLIFSISLIVIVLLQSGRRAGLSGSIAGGAETFFGK NKGRTIDAILGKYTAVAAIGFLITSVVLQLIINSK" misc_feature <72308..72472 /locus_tag="ClothDRAFT_1591" /note="Preprotein translocase SecG subunit; Region: SecG; cl09123" /db_xref="CDD:186832" gene 72763..73314 /locus_tag="ClothDRAFT_1592" CDS 72763..73314 /locus_tag="ClothDRAFT_1592" /inference="protein motif:TFAM:TIGR00277" /note="TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: sat:SYN_00315 hydrolase" /codon_start=1 /transl_table=11 /product="metal dependent phosphohydrolase" /protein_id="ZP_05429731.1" /db_xref="GI:256004755" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /translation="MEREQALEELKARIENENLIKHSLAVEAIMKDLAFYFKEDIDKW GLAGLLHDIDCEKTAGDISKHSLVGAEILESLDIESSIIYAVKAHNDYHGIERKRKID KALYCADPAAGLITAAALILPSKKLEDVTVDFLIRRMNEKSFAKGVNREQIKSCEQLG LSLEKFLEIALEAMKKISDELGL" misc_feature 72763..73311 /locus_tag="ClothDRAFT_1592" /note="Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076" /db_xref="CDD:185790" ORIGIN 1 taataataat aataataata tatatntntt ttctttgtat gatatttaat ttacaaatga 61 gaaatatata agtcgggaag ggcaatgccc ccgggcttat gaaaaggggg gacgcatgtg 121 tcggtaacaa tttcctatga cttggccaat tttattatgt atactttggg cgctgtttta 181 ataatagttg ccgttattac tttgcttaat gttaatagat ttgtaaaaag attggacaag 241 cttgtggaaa agaatgagga aaatttcaac aagacggcaa acaccattcc tgaaattgcg 301 aaaaacgtaa atgaagtaac aataggagtc aaacagaacg tggataaagt cggagaagcc 361 attgacgcag ttgaagactc tgtttgtgat agtatattga acttgcttga aggaacggaa 421 ggactatttg attttataag catagtgggt gaagtgatca aagctttgtt aaaaaggata 481 acccttggaa aggggaagta ataactggaa cttataaata acaaaggaga gctttatcgc 541 tctcctttaa tttttcatga gtagaagaat cttaccatct atcgccggag tttcttccaa 601 atcctctgtt tgatccgcta aaaccgttgt tccttctttg ctgttttctt gcctgtctgc 661 aggcgggaca cctttgaggt tcgttttgaa accctttttc caggtaaaaa gcctgttcac 721 cttccgaaaa cacgaattca gcgttgcaat ctttgcaggt taaaatttta tctgccactt 781 tccagacctc cttaataatt tggatttaac ttattcgaga ctgcacatat ttctccaaat 841 tattaaggag aaaatgagtc atgaatccaa ttaaatccct taatatgttg attatatcac 901 aaattttttc cataatcaat atattattat ttgaaaaaga ttacgtataa tcaaaaaatt 961 cttttaactc aaagcattat ataaaaagct aacaattatt atgaaattgt cataaaaatg 1021 ttataggagg ttttacagtt tggatatgag agggtaagaa agatggataa cggcaaaaaa 1081 gcagttctgc cgtataacag ggttaaagcg gtggagtatg cgcacaaatg ggcttttggg 1141 cgaaatccga aatattttaa ttttgacaaa cttggcggcg attgtacgaa ttttgcatca 1201 caggttttgt ttgccggaag caatgtaatg aattacactc ccgtatatgg ctggtattat 1261 atagatgcaa acagaaggtc tccttcatgg acgggagtaa actacttgta caattttctg 1321 gtaaacaaca aaggcccggg accttatgca gaggaaacag atgtcaaaga catacagccc 1381 ggagatataa tccagctgtc gttcggcgga gcacctcatt ttgatcattc gccggttgtg 1441 gtgcaggtgg gttcccctgc aagtcttcgg aacatacttg tggcagccca tacgtacgac 1501 agggattatt atcctcttac aaactataac tgggttaaca tcagatttat acatatattg 1561 ggtgtgagga cacaataatt gagaatacac taatattgaa gcgcaaagtt gaatcaagaa 1621 cggtattgac tatttttgag tttcattcag tatgggttca aagtcaataa gaagtatgga 1681 acggtcccca aatttggcag ttcctttgag atgcttttta cagtgactta aggaagagtc 1741 tgaaacggca actatttctt cgtcttcaat ggagatgatt tcctcgacaa catcaaccat 1801 gaaagcaagg gttttggaat ttatcattac aataatcatt tttgcttctt catccattac 1861 ctttgtatcc ggaagacgga atttttcctt cagattgagc agggcgaaaa ccttgccccg 1921 gacatttata agcccttcta cataaggcgg ggtgtccggc actttaaata ctttttgagg 1981 ccaaataatt tccattacat gggctatatt gacgccgaaa tatttgtcgt ttagcttaaa 2041 tataacgtat tgctgcgaca cagttacatc attcccttcg tgatggtctt gttttgtatg 2101 gaattttacg gaacaagcaa aataaacagg acgtgaataa tctgacctta ataatattat 2161 atcaactttt gaggcgataa tcaaatgcaa gagagggcaa ttttgacggt attgaacaaa 2221 aaaccatgcc ctttgggctt taaaggacat ggttttttaa ttgttgacat ggcaaaagtg 2281 aaaggaaaaa agcagaagca aagggaaacg atgtcccaaa ttctgtggga gtattttagg 2341 atctgtaact tccgtttatt tttacatagt catatgaaaa atcacaggtc cagattctgt 2401 cggatgcggt tccctggtta aagtcaactt ttattctgac ttcatcttct ttaagtattt 2461 cttttgcctt ttcctcgtca aagtttaatg cggcgccgct tttgcatacc aaaaggtctc 2521 cgatgtatat gtcaaccaga ttggggtcaa aatccgcacc ggaataaccg acagccgtta 2581 tgattcttcc ccagtttgca tcctcaccga aaatggctgt ttttacaagg ggggatttgg 2641 caattgcgct tactgctttg taagcatctt cagcactttt tgcaccttcg gcgacaactt 2701 caataagctt ggtcgcccct tctccgtctt ttgctatcat tttggaaagg tgtgtacaga 2761 cgtattcaag ggcggatttg aaagtggaat agtcaatatc ctccttgaca atattttcat 2821 tgtttgcttt tccgttggca aggatgacaa ccatgtcgca aacactggtg tctccgtcaa 2881 ccgatacccg gttgaaagta tgggatatta catctttgag cgctttgtcc agcagttctc 2941 tggaaatatt tgcatccgtt gttatgactc ctatcattgt tgccatattg ggatgtatca 3001 ttcctgagcc ttttgccatg gctcccattc ttactttttg cccctgaatt tcaaattcca 3061 cggcaatttc ctttaaaaca aggtctgtgg tcataatagc ctcagccgca tcgtgaccgc 3121 cttcttcgga aagttttgaa attgcctcct ttataccgga acgcaccttc ggcatgtcaa 3181 gcggcattcc gataactccc gtggaaccga caaggacgtt tttggcatca caatttagaa 3241 gctgagcggc aagagaagcc atttcctccg catctttgta gccctgttct ccgagacagg 3301 cattggcatt accgctgttt atgaccaatg cccgggcatg gccgcttttt atatgctgca 3361 tggtaagctg gagcgaatgt ccttttacaa cattttttgt aaatactccg gcggcaactg 3421 ccaagtcact ggagcaaaca actgcgatgt cctttttttg gttgttttta agcccgcagg 3481 cgactcctgc ggctttaaac ccttttgggg ccgtaactcc tccatctatt atgtttatca 3541 tttctttcac tccgtttttt attagattta tattgaaatt ttttgtattt tgtttggtat 3601 ggttggtatt tatatgacag attatataat tttatttatt agtattcaat agaatcgttg 3661 tttttagttt aatatttttt tagtaatttc acaaacaaaa aaagggtatt tagacctatt 3721 tttatagaga gcgaacagta gtataattaa aatacaaccc cctaacttca acttctgttt 3781 tactgttcgg atgatgatga agctgttccc tttaattcca gataaaaata attgaaataa 3841 agccggctaa aggttataat aatgaagatt caccacagta taatgcatat gtccgttgcc 3901 tatacttccc aactgtttta taacgctgtt aagcacatat aaaaaagggt attaaaatat 3961 taagaaacgg ttttaatatt aaatagcttt aaatagctta tgtaccggga attttgcgga 4021 aattgttacg gcttgttata ctattgagga aaaagtatag ataaagcatt ctgttcagca 4081 cagcataaaa tgcgaacctt tgcggcttgt aagtttgaat gaggtttgtc ggcagattta 4141 gagttttgct gaaagcttca aataatagta aggggatggt caaatgtccg aagcaaagaa 4201 agttataaaa aaacaggtct taccgttgct gcctctcaga gggttgacag tgtttcccta 4261 tatgattttg cattttgacg ttggaagaat aaagtcgatt aaagctttgg aagaagcgat 4321 gataaacaac cagttgattt tcctggttgc ccaaaaggat gcaaagaatg attcacccgg 4381 accggaagat atttatacca ttggtacaat atcaaaagta aaacagctgt taaagcttcc 4441 gggagacacg ataagggttt tggtggaagg aataagccgg gctgaaatat gtgagtttac 4501 ccagacagag ccctttttca tggctgaggt tgaagaaaaa atatatgttg aagaagacaa 4561 aaacagcaag acggaaatag aagccctaaa gaggagggtc ctgtccacct ttgaggagta 4621 ttcaaagctc aataacaaag tttctcccga aaccgttctg tccatcatga acattgatga 4681 ccctgaccag ttggctgaca ttataactgc caacttaatg ctgaaggtgg agcaaaagca 4741 ggaaatatta aatgagttta aaaccaaaat caggcttcag aagcttttgg aaactcttgt 4801 cagagaaatt gaaataatgc agattgaaag agagattaat ataaaggtca gaaaacaaat 4861 tgacaagact cagaaagaat actatttgag ggaacagcta aaggccatac agagcgaatt 4921 gggagacaag gacggcgtgg tcggcgaggt agaagagtac aagagaaagc ttgtagaagg 4981 caattttggc gaggaagttg agaaaaaggt gttaaaggag ctggatcgtc tccttaagat 5041 gcctccgggt tctgcggaag gttcagttat aaggacgtac cttgactgga tatttgattt 5101 gccgtggaac aagaaaacgg aagagattat agatttggac cgcgctcagc agattcttga 5161 cgaggaccac tatggcctgg aaaaggttaa ggaaagaata attgagtatc ttgccataag 5221 aaagcttaaa aaagatctca aaggtccgat tttgtgcctg gccggaccgc cgggagtagg 5281 aaaaacctca atcgcaaagt ctattgcccg cgcactcaac agaaactatg tacgaatgtc 5341 tttgggcgga gttcgggatg aagctgaaat aagaggtcac cgcagaactt atgtgggagc 5401 catgcccgga agaattattt ccgctttgaa acaggcgggt tccaaaaatc ctcttattct 5461 gcttgatgag attgacaaaa tgagcagtga tttcagagga gaccctgcgg cggcaatgct 5521 tgaggtattg gacagcgagc agaattatgc tttcagggac cattatctgg aacttccctt 5581 tgatttgtcc gatgtgttgt ttataactac ggcaaacaac cttgacacgg ttccgaggcc 5641 tcttttggac agaatggaag taatatcttt gtccagctat actgaagagg aaaaggtcca 5701 gatagcaatg aaatatcttt tcccgaaaca gattgaggct cacggcttta agaaaagcaa 5761 tctgaaaata gacgaaccgg ctgtgagaga aataataaac tgctatacaa gggaagccgg 5821 agtgagggag cttgaaagac agatagccgg cgtttgcaga aaagttgcca gaaagctggt 5881 atcctcaaat cagaagacgg tcaaaattac tgcagcctct atagaaaagt atttgggaac 5941 gaaaaaatac agatatgaca tggcaaatga aaaggatgaa gtgggtgttg ccacaggtct 6001 tgcatggacg cctgtgggcg gagatacgtt gtccattgag gtaacactta tggaaggaaa 6061 gggcagcctc gagcttacag gacagctggg agacgtcatg aaagaatctg cccgggctgc 6121 aatgagttat attcgttcaa gagcggaata ttacggaata gacaaggatt tttacaacaa 6181 gtatgatatt cacatacatg taccggaggg agccattcca aaggacggtc cttcagccgg 6241 tataaccctt gcaaccgcaa tggtgtctgc attaaccgga aagccggtaa gaaaaaatgt 6301 ggctatgacc ggggagataa ccttaagagg cagggttctt ccgataggcg gagtcaagga 6361 aaaagtgctt gccgcccata gagccggaat agatacaatt ataattcctg tggaaaacaa 6421 gaaagacctt gaagagatac ctgaaaatgt aagaaagaca ataaaatttg ttctggcaga 6481 caatatggaa acggtgctca atactgcatt ggtgaaaacc aaaccgaagg gcaggcaaaa 6541 gagcgtttcc ggtgaagaaa aaactgttgt gccggaagtt cctccgcagt tggaagaatt 6601 ggatcacgga accgcaacaa ttgaacagta atacaggatg tcaatatata aagaatgttg 6661 atatttataa taaacaattc aaatataaat gcaagttata taattgctgt cagataaata 6721 tgtaaatcat acaaaaccaa tgtaaaatat acaagaacag ctgttttaca aaacgtaaga 6781 cggctgtttt tttatgtgaa ttcattaatg taaacaaaat gtaaaggata gttttcatat 6841 tgaatttgta taattaaaca attgcagatt taagtatcta atggtagaat tagaactata 6901 gtaaaaaaat taaaacagcg ggttaccata atgagggcat ggaatgagaa gtattatacg 6961 cgccttttta aagtataagg aatatgtatt gcttgcaata atagctgttg ctgccggttt 7021 agtatttgga attgcatatt ttttgaagga acaattcagt gccgtaatga ctgttgagag 7081 ttttttggca tggcacaata tacttgaatt tacaagtgta ctgttctcct ttactgtttt 7141 tgcggtctct tattatactt acgaacaaac cggaaatttg cgatccgttt ttttgggcag 7201 tgtttttctt gcagtaggta tggtggatgc ttttcataca ctgtcatata agggcatgcc 7261 cgcatttctg attgaaaaca acagttccaa cagagctaca atcttctgga ttattgcaag 7321 attgtttaca gctcttggct ttttcatatc aagtttgata ccggctagtg tcaagattcg 7381 gacaaagcgg ataatatttg tagccgttcc cctgattaca agcatttccg ctttgtatct 7441 ggccacttat catcctgaac tgtttccgcc gatgcatatt gagggaaaag gtcttacttt 7501 ttttaaaatc tattccgaac acctgattat tatattgttt gccctgtctg ttttaatgtt 7561 tatccgtgag tataacaaaa caaaaaacaa aatggtactt cttctttgtg tttctcttga 7621 gataactatt ttcagtgaag ctgcgtttgt cctgtatttc agtgtttatg acatatataa 7681 ttatcttggt cacgtgtaca aatttatagc attcttcatt attttcaggg ctatttttat 7741 taacgatata caagagccgt atcgaaagct ttcaaaggca aaagaaaaac tgaggaacca 7801 tgccgaaaac ctggacatga tgatcaggga aagaacaaga gagcttgaaa atctcaatca 7861 gaaactcatg caagatttga aatatgcccg ggacatacaa aaatcggttt ttaagctgcg 7921 caatcaggat tgggaaaaag tgcggtttga agtgaaaaac tattcttctg aaatggtaag 7981 cggtgatttt tgcaatgttt ttaaaattga caacgacaat atagggtttt atatcggaga 8041 tgtgtccggc cacggtgttc cggcggcaat gcttacgata tttttgaatc agacagtgaa 8101 gactttgctg gagatggaaa caaacgaact taacaaaatc agtccggcaa tggttttgga 8161 aaacatatac cgttctttca actcaacaaa cttcgacgaa aatgtatata ttgtcatgat 8221 ttatgcggta tacaacaggc acacacaggt tcttacttat tcctcggcag gtcttaatgt 8281 ttcgccgatt cttataaaac cttcaggaga aattttggaa atagaaataa aaggctttcc 8341 catatgcaaa tttattgagt tttatgacgg agaatatcaa aatcatgcgt taaagcttaa 8401 taaagatgag aaaattttgt tttacaccga cgggcttatt gaagcacaga atacggacag 8461 gaactttttt ggagacatga gactgaaaga aattttacag gaaaattata ataaatccgc 8521 ttccgaactg tcaaagctga tttccgacgg tatttttgga tttaccggga aaaaagaaat 8581 taaagatgat ataacgttcc ttatcatgga agtagtagaa tgataaagaa tgttaatcct 8641 aatacttctg gtttatgtag ctgtccacca gggaatttct tacttcgttt atgaagacat 8701 tttctttcat aagcatgttt aaaatagctt cactttttga gtgaagaata atgttgtcat 8761 agtccaaaag cacaatttca aacaactttt ttctgagatt ttttgacttt acctttacaa 8821 aatatgcttc tattccttta aagtccaaaa gtctaagaag ttttgccgta acttcgtcct 8881 tttttgaata gtaataatta gactgttcaa gaaaatcact tctcgcctca tgattgcgac 8941 ttaggtcatg agcctttttt tggtaatatt ttgccagaac attgtagtat tgataattgt 9001 atattgcttt ttttacattg tcaatttttt gaaatggttt tatatcgagg gaatttatgc 9061 acctgtagtt tgcttcgata aattcctctt ttgtcaggtc ccctttggca tactgctcga 9121 taaggctttc tctgtttttc agaaattgct caaatttatt cggtacaatc ttctttgacg 9181 gcatccttat ccaacctgtc catattataa tgtgttaaat ttattgttgt ttatatatta 9241 aaatataaaa gataaaaagt aaaggactac tgtttttaag tggagcttat cttcctgtga 9301 gcttgacagg aaacttggga aaaattgcat cggcaaaagt tgcaggctgt tttaaacaga 9361 gtatccgttc caaagtttca ggtttgaagg tccggaagca ttaatttgaa tctgcgaaag 9421 agaagcatac cgatttgcaa cgaaaacgaa gagttaatga aacccaaaaa gacgttatag 9481 ataatctccg gtaattttgc aaaaaatacg gaatcaggag attatctatg aaaatagtcg 9541 tttattgttt ccaccgcatt atactcaatt attttttctc cgtgttcatt caggtagcct 9601 tcgtaaaagc tgacgttgct gaccttggtt ccgaactcgc ttaaaatagg ctcaaacgac 9661 cttaaatttg ccactgacca tgaatttttg gtaagaacca ggtaataaac tcctttaagt 9721 ctgtacagag tgctttcgcc tgagtaaatg tccctgagct tctggcatac agagcacaag 9781 tcttcaaaat tattgaagaa atatatgact atagaagagg agaccctgga atttctcttt 9841 cttacccgaa gatcggactt tctgaatctg ttttttatat atttgtgaat agattcgaat 9901 tcaccgtctt catccagttt tgtaattata ataacaaaac cttcttcagg atcagggata 9961 gcctcaacac atatctggga atcggaagca tcaaaaccga actggatttc cgcctgttcc 10021 atcatgtccc agaacaattc ctgtgccgcc ggagtattgt aatttagtgt gtcaaggtct 10081 atgtttcttt ccagcaagtc gtcaatggaa attgtgactt tgattttatt ttcgtttatt 10141 ttttcaattt tcataagtat caccagattt ctttgtaaaa attatatgcc tatatatata 10201 ttatacttct aataaatgaa aaagagaagt ataaaaaaat taacaacata taaaaacttt 10261 aattagaaat ctatatcaat tttactgatt aaaaaaggta ttaacagaaa atattatatg 10321 tccgtagata aaaatacaaa gcgaaaaaat ccttcttgag gatgaaaaaa taagctgttt 10381 tgcaaacgtt atttgttcaa ataataaata tgattaataa taaatatcat tttacttgta 10441 ctttagtata tcctgtgtaa aaaaataagt attatcctat gccccaaaat agtttatggg 10501 caaagttcaa gaatttaacc ggggagatga aaatatggga aactttatag acagaacaga 10561 agaaaaggaa gctggcagta cactgccgga aattgtatat aatcaggaaa aggactttta 10621 cagagctatt ggcggcgaat tgagaatgaa agcagaaggt ttgttcaaaa aagcaaagga 10681 aaagggaata tcgattgaag atgtttccat taacatttta aaagaaaatc gtgccgaatt 10741 tcccggcctt ggagaagtgg agcttccgac atttattgtt aagattcggg ggagggatat 10801 gtcaaccggg caaattattg ttgacggaaa acagattgat tattacaaca gataccaaaa 10861 atatattgca aaaaaaatag aggaaaagaa tatggttgga aacgatgaag caaaggacag 10921 ccaaaaaaac agggtaaaag aaaatccgga attttacctt accgactggg agaaattcca 10981 aattggaaag gatatcattg aggacaagga atttgggctg gaaaagacca taaccggcgc 11041 atgtgacaga ataataagaa aacttatggg ggaaaatgac tggctgtctc cacaggaagc 11101 aagacttttg gatgaggagt ttaattctgt ccagagcagc atgcaaaaaa gtcaggagaa 11161 aaaacagaag gagttgatcc ggaaaaagaa agcaacccca agacaaatta attattttaa 11221 acagagaata aagaatatgg gtatgaatcc tgacgatccg aagatgcttt caaaaatttt 11281 tgaccgggtg gggattgagc cggctgatat cagtgaatta agtatagccg acatgagcaa 11341 aattatagag agtttgaatg acatcgcgcc taaaatcagg gaaggaaacg agaatatgtc 11401 tgaaatcagg gaacagtaaa aattactatt taaaatctgt attcaagtat agtataatta 11461 gcaaaaacaa aatatataaa aaagtatata agaattaatg gatttgtaat aagaaattaa 11521 tcaaaaaaat tcatattttg ttgaaatagg acagtatgta tgattataat atttatatgc 11581 ttaagtttat attttgagtc aaattgggat gttctgctta atatcaaatt ttattttatt 11641 tttattaaaa cagatttaaa aaagttttgt ttgttatggg gtggatatgg taaaaattgt 11701 tttggcgtcc ggatcaccta gaagatccga gcttttaaaa cagataggtc ttgactttga 11761 aattgttctg tcggacatag atgaaagcaa tgaagaaaat cttaaagcca acgaactggt 11821 acagcatctt gcgtataaaa aggcttatga tgttgccaaa aaagtggcaa acagagagaa 11881 cggaaaggaa agatacctgg ttgttggggc ggacaccgtg gttgtcaaag acagaataat 11941 gggaaagccc aaagacaggg atgatgccgt aaggatgcta aagcatctta gcggaagctg 12001 gcatgaagta atgacgggta tagcattgat tgacacgaaa gatttcagaa gcgtcacaag 12061 tgtggaaatt acaaaagtta agatgaagga acttacggac gatacaattt tggcatatgt 12121 ggacacaaaa gaacccatgg acaaggccgg ggcttatggt atccaggaaa aaggggccat 12181 actggtcgag cgaattgagg gatgttattt caacgtggtg ggattgccgc ttggaaggct 12241 ttccgatttg cttaaagatt ttggagtttc tgtacttaaa aaaatttagg ttataacagt 12301 acttatgagc gtattgatgt cttattacaa aagataaaat tggaagtgtt taggaggaga 12361 aaaataatgg gcttttttac aagagatatt ggaattgact tgggaacagc aaatacgttg 12421 gttcatgtta aaggtaaagg aattgtagta agagaaccgt cagtcgttgc aataaataaa 12481 aagaacggag aaatacttgc ggtgggcgat gccgcaaagg aaatgatagg aagaacaccg 12541 ggaaacatag tggcaatacg gcctatgaag gatggagtta ttgcagactt tgaggttact 12601 caaagcatgc tgaagtattt tataaaaaag gccatgtcaa aaggagtttt tggaaaaccc 12661 agagttgtca tctgtgttcc gtcgggtgtt acggaagttg aaaagagagc ggttgaagaa 12721 gctacccttc aggcgggagc aaaagaggct tatcttattg aggaacctat ggcggcggca 12781 ataggagcca accttcctgt tgaagagcca tcgggaagca tggttgttga tatcggaggt 12841 ggaaccagcg aggttgcggt tatttccctg ggagggattg ttacaagcaa gtccctgaga 12901 attgccggag atgagctgga tgatgctatt gtgcactaca ttaaaaaaga atataattta 12961 atggtgggag aaagaaccgc tgaggaaatc aaaatgagta ttggttctgc gtatcccagg 13021 gcgaaagaag aatcgatgga aataagagga agagacctta ttaccgggct tcccaagaat 13081 ataattatta cgtcgtctga ggttatggaa gccataaaag agccaataaa cgccatagtg 13141 gaagccatta aatttacttt ggaaaagacg cctccggagc ttgcggcgga cataatggac 13201 cggggaataa tgctcaccgg cggaggtgct ttgctgagcg gactggacag acttatccgt 13261 gaagagacgg gaatgcccgt aaacgtggct gaaaatcctt tggactgtgt ggcagtaggt 13321 tccggaaagg tgctggagga catagaaaca ttaagaaagg tgctgatttc tcctagaaaa 13381 cctagataga agggagataa tttctttgcg ttttgttaaa aacaagcatt ttatattgct 13441 gacggtaacg gtggcaattt tgattataat agggctttct gcgagaaaaa acagcaaaat 13501 aaatactgtc agcaatgttg ttaccgttgc gttaagtccc tttcaggagt ttattaatta 13561 tctgggagac agggtagagg gggccgctaa atattttcag gatattgagg cgttaagtca 13621 ggaaaatgaa gcgttgaagg tacggattag cgagctggaa aaagaagtaa aagagctttc 13681 cgactacagg gaaaagaaca aagagcttaa agaggcgtta aatataaagg accaattcag 13741 tgatgtggaa tttcttggtg cgaatattat tgccaaggat atggggaact ggttccatac 13801 ttttacaata gaccggggaa tagccgatgg tgttaccgtt gattcggccg taataacaaa 13861 agacggactt gtgggaagag tgataagcac cgatcttttt acttccaagg taattacgat 13921 tattgacgaa gacagtacgg taagtgcaag agtgtccaaa acaagggatt tggtttttgt 13981 caaaggtgat ttgcagctta aaaatcaggg attgtgcaga ctggacaata tttttcccga 14041 catggatata gcggtgggag atacgataga gacttcagga ttgggaggca tatatccaaa 14101 aggtattatt ataggcaaag tcaaggaagt cagacgtaaa accaatgatc tcaacaggta 14161 tgcaattatt gagcctgccg ttgattttaa acggcttgaa gaagtgtttg tgctggaaag 14221 caaaaataat aaagataatt atgaaaaagt aggcgaagac aacaaatgag agcaaaaccg 14281 gttagggtta aaataatttc gtatgctgct cttatattta ttatagcgct aattcagtcg 14341 acggttttag aaagcatcag catattcaat atcaaaccga atctgttgtt gatattcatt 14401 atttccgtgg cacttttagg aagcaatatc gagggtgccg tgacaggttt tttgtgcgga 14461 ttgactcagg atatgctttc aggaagggtt attggctttt atgctttgct ggggctttat 14521 ctcggccttg gaattgcttt gataaataaa agattataca aagaaaatgt gttggtggca 14581 attttcacga cttttgtttc ttcgataata tatgaatttg ccgtttattt ttttgtaaat 14641 gtgtttaaag gctctttaga gctgattttt ccttttagat atataatttt gcctgaggcg 14701 gtttacaata gtgcggtgtc aattgtcata tttttaatag ttttaaagat aaatcactgg 14761 tctgaggaat tggagcggct ttcgagacgt tattaatgct ttcaatcaaa gtttgttgcc 14821 tgactcttca aaatagcgat caaaataacg aacagaggaa gtgaatgggg gtctccccga 14881 cgtcgagtgg ttgaacggag ggtgaaaata tgggtgagaa gaagccggtg gacaagataa 14941 gcgaaagata caggattatg gtaatcagtt ttactttgat ttttgccgtg attgtagctc 15001 aattggtaaa tcttcagatt attaacggag aatactatga tgaacaatcc cagaccaaac 15061 ttttggcaga aagggatatt attgctccaa gaggaaaaat tgtcgacagg aacggagtac 15121 ccatcgctgt caatagaatg ggatatgccg taaaaattgc aaaaaccggc atgacggaaa 15181 aagaaaaaat gaaatgatac ttaaacttat aaatatattt gaaaaaaacg gcgactccta 15241 tgaaaagaat ttgagcaact atcttacgtt caatcccata gcttttggtc cgaaaaacca 15301 gtctgaagac gcacttcaaa gatggaaaaa agacatggtt gtcaaggctg atgatatgaa 15361 acttttagaa actccggagg atgtttttaa gtatttcagg aagaaatttt acattgatga 15421 cacatatact gacgaggaag catacaagat aatgaccata aaatatgata tgcttataaa 15481 gggatatact gcaacaaatc ctttgcttgt tgccaaggat gttaaagtgg aaaccgttgc 15541 ccagatagag gaaaggagtc atgaatttcc cggagtcatt attgacgtaa ttccccagag 15601 aaaatatgtg gatgcaagct ctgtggctca tgtgttgggg catatagggg ttatcagcga 15661 agaggaatat aagacctaca aggacaatgg ctacaccatg aatgatatga ttggaaaggg 15721 tggaattgag aagactcagg aaagtcagct tagaggtata aacggaaaaa agagggttga 15781 agttgacacc aacggcaggc ttacggcgga actgagcagt gaacctgcta tacccggtaa 15841 tgacgttgtt cttacaattg atatgagact tcagaaagta gcaatgaagt ccctggagga 15901 aaatatagag agaatcagat ccaaggcaga ttacaagaag aactttggag atgcttcttc 15961 gggagcggct gttgtcattg acgtaaacag cggagaggtg ctcgccatgg caagctatcc 16021 cagttatgac ccgtctgtat tcctggcagg accgcaggac aaggaggcac agaaaacgat 16081 aaatgctctt ttgactgatg aaaagaataa gcctctgttc aaccgggcta tacagggagc 16141 atacactccc ggatccacat tcaagccgct gatcagcatt gcaggactcg aaacaggcgc 16201 aattactccg cagaacagtt atattactga cagaggaact catgtaatag ggggctggac 16261 attcaagtgt atggagtatc cgacttacgg tcatgggaca atcgacgtcg taaaggcttt 16321 ggctacttcc tgcaatattt actttcatga gcttggagta aaggtcggaa ttgacaatat 16381 agatttgtgg gcgaaaagat ttggactggg tgagtatact ggtattgagc tgccctggga 16441 gaataaagga atcagagcga acagacaaac caaaaaggaa ctcaggaatg atgagtggag 16501 acctgcggat acagcccaga cggcaatagg gcaatttgac aatgctttta ctccgattca 16561 gctggcaaat tacgttagca cattggcaaa cggaggaaag aaatacaaac cacatatagt 16621 aaaagaaata cgtaaatatg acggttcaac ggtattaaaa agcgaacctg agtatgagca 16681 gttgcctata aaagaggaga caatgaagat agttcatgaa ggaatggtgg ctgttgccaa 16741 tacggaagac ggaacggtaa atcagctttt ttccgatttt ccttttaaag tggcgggaaa 16801 aaccggtact cccgagacag gacttgagca tctgggacag tcatcgaacg gtgtctttat 16861 tgcatatgct ccggccgaca atccacaggt tgccgtggca gtggtaatag agcacggtgt 16921 ctggggttcg gaggttgcac ctgtagccaa ggacatattg cgagaatatt tcggtatgaa 16981 caatgacagt ctgccaaaag atcagattgt tgttgataaa ccaagtttta cgcgctagtt 17041 tgtgtattca gcgtgcaatg tgtataaaag agataaactg acggatattg gaggttgctt 17101 ttgatgagtg aaggtagtgt tatttttaag gggtcattaa acgggcttac tattataatg 17161 aaggaagaag aggattatga ttcgatactt aagcagattg aagacaaaat agcctcatcc 17221 ggaaggtttt tcaaaggagc aatcctttct gttaaataca ggggaaaaaa gcttaccgaa 17281 gaacaggaaa gaaagctttt tgaattattg agggacaaaa gcggggcgaa aataaaaagc 17341 cttgaggagg acacggaaga gcccgtaaaa cctgaacccg tgcagcagca gccaagattt 17401 cgctccaaaa tcagaatgag caacttttat ttcaagggat tggaggaagg tattacaaaa 17461 tttcacagag gtactgtgcg ttcagggcaa ttggtgagct ttgacggaaa tcttgtgata 17521 atcggcgatg taaaccccgg cggtgaggtt tgtgcaaccg gacatgtcat tgttatggga 17581 tcgcttcgcg gcatggttca tgcaggggca aacggaaaca gggaagcttt ggtagttgct 17641 ctgaatttgc aaccgaccca gcttagaata gctgatgtaa ttacccggcc tccggacgag 17701 aaggaaactg ttgggcaatt tttccccgaa ttggcatatg tcaaggatgg catggtatat 17761 atcgaaagat atttgcctgc aagatgaagc aaggacaatt tagaagcatg cataatatac 17821 tttatatgta aaaatgaaga attgacaaat cagtaaaaga aatatatagt ttaattaaga 17881 gtttaaaagg attttgcctt aaaaagggat tttggtgttg acacgccgtt acaaatatat 17941 gtttaaggag gaaatatatc tgttaaccgt acgaaattga ttatacttag gaggaatata 18001 tatgagcgag gtcattgtaa taacttccgg taaaggtgga gtgggaaaaa ccacaactac 18061 cgcgaatatc ggaacgggat tggcacttca gggaaaaaag gtggttttaa tcgatactga 18121 tataggactt agaaatcttg acgttgtcat gggtttggag aacaggatag tttacgacct 18181 ggtggatgtg gttgaaggta cctgcagaat taagcaggct ttaataaaag acaagcgttt 18241 cgaagggttg tatcttcttc cggcggcgca gacaagggac aagactgccg taaatcccga 18301 gggcatgata aaattgtgcg aagaactgag aaaggatttt gattatattc ttatagactg 18361 tcccgcaggg atagagcagg gatttaaaaa tgcgatagcc ggagcggaca gggcaatagt 18421 tgttaccact ccggaagttt ctgccgtaag agatgcggac aggataattg ggcttttgga 18481 ggcaaatgaa cttaaaaatc caaagcttct tataaacagg gtaaggcagg acatggtaaa 18541 gcgcggcgat atgatgtcga tagatgatat aatagatatt cttgcaatag atcttatcgg 18601 agtcgttccc gatgatgaaa aaatcattgt ttccacaaac aagggagagc cagcggttac 18661 agacaataaa tccgcagccg gagcggctta cagagcaatt acaagaagaa taatgggcga 18721 ggatgttcct ttgcttaatt tgggctctga agacggtttt atgtttaaaa tcaaaaagtt 18781 gtttgggtta aaagtaaatt gagaggatga gacctatgtt actggattta tcaaaaatat 18841 ttggcaaatc caaaaattca aaggatcttg ccaaggaaag gcttaagctg gtactgattc 18901 acgacagggc aaatgtttct cctcagtttt tagagatggt caaaggagaa attattaaag 18961 tcatctctaa ttatatggat gtggatgagg aatcactgga tattcagatg acgaggacaa 19021 aaagcgaaga cggcaactcg gttgtacctg cgctggtagc gaatattccc attagaagtg 19081 tcaaaaacag cggcaaataa aatataatcg gtgaattctt atgaatattg cgttaattgc 19141 tcatgacaag aagaaagaat taatggcttc attttgtatt gcctacagga gtatattgaa 19201 aaatcatact ctttttgcga cgggtacaac gggggcaatt atagttgagg caaccggact 19261 caatgttcat aggtttttac ctggggtgat gggagaacag cagattagtg ccagagcagc 19321 ctataatgag ttggacttgg ttattttctt cagagatccc attagcgcca aatctgatga 19381 accggatata cattctttat tgagagaatg cgatattaat aatattccct ttgccacaaa 19441 tttaggtacg gctgaaatgc ttataaaagg tcttgaaaga ggcgaccttg actggagaga 19501 acttattaag aaataaaatg gcaataaaaa ggactccggc gcaaaaaagc cgggtcctta 19561 cggtgtttgc tctctattca agtcttgcct caagctcatc atacacttct tccggtgtca 19621 ttccggaagc atctatgata attgcatctg tttcagtatc ttcaattcca agcatgtttg 19681 aatccaaacc tgatacaacg aaagcgtcaa actcgtcaac aagacttgat atttcttctg 19741 catctgtaaa attaatattt tcaacttcat atcctctttc ggacaaaaac tcttctatag 19801 gcgtaagatt ttcttccact gcgactctgg gtttcaaaat tccacctccc ggttaattaa 19861 attgcttgtt ttcttgatgt tcggaagcag cgtcatttaa tattatttca agcgaattgc 19921 taattataat tggaaaatta attcactttc gatttattgt aatattctta aaacaaatca 19981 aatataatca aaatataaaa atactgacag ctcatcttac atacattgtt aaaaaatatt 20041 aaaaaacttt acggggatgt gtttgccgtg gacgatattg tttacagaca aagataccca 20101 agatataatg tccaacaaag tctgagaaga acaaggaaga gcaaaagaaa acggggaagc 20161 ggggaaagac ttaacctcgt tcaaaagttt gtgatacaaa ctgtcgtatg tgtcgttgtt 20221 cttttgacgg ctgtactcat taaaaatatt aattcaccaa ttaccaatta ctgcaaagac 20281 aaaataaagg gaatcctgtc ctataatatt gacattaaca gtgtattcgg gaaaattgac 20341 agttttttgg caagtgccgg gaataataaa agtgttatca aagaagatga gagcgttgaa 20401 gatgttgttg agaatgttaa cgagaagtca ggttcgcaaa aagatgcttt agagagtgaa 20461 aatccggctg aagaagaagg cacatatgtc aaatccgctg aaaccgtctt gacagacaat 20521 gaaacagaaa accaggaaga tttgccgaat tcatttatta ttcctgtggg cggaataata 20581 ggagcgttgt acggtgaaag agtttacacg ccagaaggaa cggaagagat tcaccaggga 20641 attgatataa aggctttgaa aggtactcct gtaaaagctg cggcggaagg tgaagtaata 20701 gaggccgggg aaaaccaaat atacggaaaa tacataaaaa tcaagcacgg ggaagatata 20761 atatctcttt acgcccattg ttcggacctt ttggtaagca aaggacagaa cgtaaaaaaa 20821 ggcgagacgg ttgcaaaagt gggaaatacg ggtacttccc aggaacctca tcttcatttt 20881 gaagtatggg aaaaggggac acccgtaaat cctctggatt acatccagtc tccttcaaat 20941 taggacttag gtatggttat aggatataaa ttaaataata aataggaaat ggggataatc 21001 atatttttgt caaaattata aaaaggccgt ttgaagttga aattgaccct gtttttgcgg 21061 tattggccgc aataatgtat taccacaatt atttaatgga atatttatta attttttttt 21121 ctatggcaat tcacgaaacg gctcacattg ttgcggcggc agtgcaaaaa agaatacttg 21181 tttcggttag gattacagct ttagggttaa atgccgtcat aaaagaaaaa catgatgttg 21241 atgcaaatcg ttttttaata aacatcagcg ggccatgtgc aaatatttta atgtttttta 21301 tttgtattat aattaaaacg tattatttta acgccggtta taatatgcgt ttttttatct 21361 atgccaatat atgtcttgct ttatttaaca tgcttccgat tctgcctttg gacggcggaa 21421 ggattctaaa agacgttctt gtttcaaaaa tgggtcttgt caggggatgc aaatatacaa 21481 gaagactgtc tttgatattt tcggctttgc ttttggttct tggaattttt caatatataa 21541 taagtaaata taatttcagc atacttttaa ttgccggata tatgttatat ttccaaaaaa 21601 gcgacagacc ggaggagata ttaatgaata tcagaaacct cttgtttaaa cgttcaaggt 21661 ttttaaagaa aggagtttat ccggggaggg aattggtggt attggaatcc acccgtttgg 21721 gggagttgat aaaaagcatg gattttgaca ggtttcatat tatatatgtt gtaaatgaaa 21781 acatgcgtgt ggtcagggtc tttactgaac aggaaattat cgattatata atgaaatata 21841 atgcggatat aagttttagg gatttaatgg aaactgtgga ctgacggaaa atgatataca 21901 agaaagggca tatacaagat agtttatatg tatatacccc tttaaaacta ttttaacaat 21961 cctatatttg taagaatttc cctggtggat ttgggtctgt tcattgtaag aagatgtatg 22021 ccgtccacac cgttgtcaat caaatcgcgt atttgattgc tggcgtactc gatgcccgcc 22081 ttgcgcatgt cctcgtcgtt atcgccgtat ttgtccatca ttattaccag ttttgcggga 22141 atggatgcac cacaaagata tgtaatgcgt ttaatctggt cggctttaaa tatcggcatt 22201 attccgggag taatgggaca cgtgatacct attgaggctg ttttgtccag aaaatcgtag 22261 aacagccggt tgtcgaagaa caactgtgtt acaaggaaat caaccccggt gtcgactttt 22321 tgcttaagat acaaaagatc atctttaaga cgtttgctgt taacatgacc ttccacgtaa 22381 gctgcggcgg ctatgcagaa atcatttctg ttctgttttc ttacatgggc aataagttca 22441 tttgcatatt taaaagcatt attactaaaa tcaaaatccg gttgatttgc cggggggtct 22501 cctcttaaag ctagaatatt ctcaaggttg tgttcgcgca tagatgtcag gagagcatct 22561 atttcctctt tggaatgtcc gacgcatgtc agatgtgcca tactttcgat accatactcg 22621 tttttaattt ttgatgcgat ctcaatggtt ctgtcttttg cgcttcctcc ggctccgtat 22681 gtaacactga taaagtcagg ctttaattcc ttgaactgtt ccaaagttcc gaatatggac 22741 tcgatgggag tatcaagctt tggaggaaag atttcgaagg atataaccgg tttctttttt 22801 ttgaacaaat ctaccagatt cataacaggc ctcctgcaag aaagaatctt gacattatta 22861 tgtttggcgt gtaattatgt taaaatttat tatagcatag agtcatggac tgtcaagttt 22921 gggaaaaaga gatacctttt cggtaaccga tgatataact tttggctgaa ttaaaaaata 22981 agttttttag agggctaata gttgcagttt ttatatataa agtttataat gcttttataa 23041 ctgttgtttg tttaatgtta tttaatacac ggcggattta acaaatgata tggttgaaat 23101 atgaaaagat atggggaata atgaataaag aatttatttt ttcatatgat gtatttaagt 23161 acaaatagga ccgataataa caaacgtata tgactttgtc aattatttag gatttggagg 23221 taaggtacgg cttatgaaac ctaaaatgtt ttttaaggcg attaccaaat tcagaaatat 23281 tcttttgctt gcgatagtaa tcggtatatt ctttgcaact ctaaataaca tcagcaacgt 23341 tcctttcctt ttgataggag ctgcgtgtta tatatactct gtaatccgga ctcttaaaaa 23401 tccgaggttt atggcggagt ttaacaggga gatacagttt gaaagcattc aggacctgaa 23461 cgaggaatgc aacaggttgt atcaaaatgc ctttaaaagg ctgccggcgg gaatgaggga 23521 gagaatcaga aatatctata aggaaaagca ggctcttgtg gcttactatg tacggaccaa 23581 aagcgatccg gtaaagcaaa ggattgtgga acaggcttta aatcttgtta ttgtttattt 23641 taaacttatg cttaactata gtataagaat caaagaggta aattctgcaa atgtccagaa 23701 aatcgtggag cgcattaatg ccaacaagag aaaattgcaa cttcttacaa acccaaaggc 23761 cgtggaagat ttggaaaggg cagtggagct tgatgaaaag ataattgaaa gaataaataa 23821 tgaaaaaatt gagttggaaa cgataagttc caaactggac tatattgaaa gtgccatact 23881 catgtttaaa catcagatta tatccaatgc aagcacggaa cctattgccg aagatattga 23941 caatgtgata aacgaagcaa ttgctttgga taacgcatta acatcccaca gaaacgaaaa 24001 actaagacta tactgaaaag gaggaggttt tatgataaac tttgtttata aaaatccaac 24061 gaagataata tttggcagag gtactgaatt gaaagtcgga gaagaagtca gacaatacag 24121 tgggaaagta ttgcttcatt atggtggagg cagcataaag aagaccggtt tatacgatag 24181 agtggttaat tccctgaaac aggcaggagt tgaagtggtt gagcttggag gagtcatgcc 24241 caatccgagg cttggccttg taaacgaggg aataaaaatt tgccgcgaaa aaggaattga 24301 ctttattctg gcggtaggcg gaggaagtgc cattgattcg gcaaaggcta tagcagtggg 24361 agtgccgtat gacggcgacg tatgggactt tttctgtggc aaggccgaac cgaaagaagc 24421 ccttcctgta ggtgtggttt tgaccatacc tgctgcggga agtgaagcaa gcccaaattc 24481 tgtaataacc agggaagacg gcctgtacaa acggggaatg tactctgagc tgataaggcc 24541 ggtatttgcc attatgaatc ctgaattgac ctatacgctt cctgcatatc agactgcgtg 24601 cggtactgct gatatcatgg cgcatataat ggaaaggtat tttacaaacg aaacccatac 24661 agatttaaca gaccgtcttt gcgaggctac gctcaaaaca atgattaaga acgtgcctat 24721 tgctttggaa gagccggaca attataatgc aagggcggag attatgtggg caggtacaat 24781 tgcgcacaac gggcttttgg gaaccggaag aattgaggac tgggcatccc ataatattga 24841 gcatgaaatc agcgcgattt acgatgtggc acacggagcc ggccttgcag tggtgttccc 24901 ggcgtggatg aaatatgttt acaaaaacaa tttggaccgt tttgtgcagt ttgccgtaag 24961 agtgtggaat gtggaaatga attttgacga gccggaaagg acggctctgg aaggtataga 25021 acggctgaaa aagttcttta aagaaatagg tcttccggtt tctttgaaag aaatgaacat 25081 aggcgatgac aggctggaag aaatggcgtc aaaatgcacg aacggaggaa aagctacaat 25141 cggaaatttt gtaaaactca atcgtgaaga tgtgtacaat attttaaagc tggcagtgta 25201 atcgaaacga acttaaatat attaagattt tttgcgggaa tttatgtacg cgaaaatata 25261 tatgaaaaag aggacgttta tgtcctcttt actttttttc agcgatgaga aacttaattt 25321 tacagccctg ttcaagaaac attctttcat gttcggtttc aatgttacct tcaaaaccgc 25381 ttgcatgcaa atcttcggtc agataaacga tattgaagtt gcattgttca aaatacttta 25441 tagaatcctg aaacaacatc gtgtcgtcgg ttttaaacca aatttgtcca ttgggagcca 25501 gaaacgttct atactggttc agctggtttg gatgcgtaag acgccttgcc ttgtgacggt 25561 ttttaggcca gggattgcag aaatttataa aaattctgcc aatttgatcg ttttcatcca 25621 gcattctgtg aataagcatt atttcatggg ccataagccg gatgtttttt gtctcagcgc 25681 caatcaaagc atattcattt tcgatttttt tcattgcgag ggccagcact tcatctttaa 25741 tatcaacggc aataaaattt ttatcgggat tggtagaagc aagctttgat atgaagcctc 25801 ctttaccgca cccaagttcc aaccatatct cgttggaatt gccgaatact tcgcgccatt 25861 ttcctttata ttctgtcgga ttgatgacaa aaaaactgca tgcttccagt gcaggccttg 25921 cccaaggttt ttttctcagc cgcataccat tacctcgcat tacttttatt atgtttgatt 25981 tttgtaaact ttgttttgaa aattgtcttg caccaaatta ttttaagact gtttgcttaa 26041 aaattcaacc tgttaattaa taagtatttc caaacttttt gccgggtatc cttttcggaa 26101 aaagatttaa atgcccttgc agaaaaattg gtgaagaaat agaattataa ataaggaaaa 26161 aggaagaaat aatataaaaa taagagacaa ggagtgggaa gatgctggaa aggcttagta 26221 taagaacttc ggcaagaacg gccatgattg atataacttc aaaagttcaa caggttgtgg 26281 aaaggtccgg ggtaaagtcc ggaatctgca ctgtttttgt tccccatacc actgcgggaa 26341 ttacgataaa tgaaaatgcg gatccggatg tggtgtcaga cattctgacg gagataaata 26401 aaattgttcc ttttgaggat ggttactccc acggcgaagg aaattccgcc gcccatataa 26461 aagctagcct gtttggctct tcacagcaga taattattga aaactccaga cttcttttgg 26521 gcacgtggca ggggatatat ttttgtgagt ttgacggacc gagaaacagg gaggtatatg 26581 tgaaaataac ttaacctttt ggttttatat ttcttgacta ttgggagctg tttgtgatat 26641 attttattta aaaattgaat attccaagag ttgacttatc ttcagggata ggtgaaattc 26701 cttaccggcg gtagacagca tggtatttgc tgtgagcccg cgagcctttt tggcagatcc 26761 ggtcaaagtc cggagccgac agtgaaatgt attaatatgt tttgttatta atacattgag 26821 tctggatggg agaagataaa gcattatttt tttgtttgga agtggcgctc cctgggaaga 26881 tatctcaagg gggctttgtt atatagttta atgtatttta acggaatgaa cggtgattaa 26941 gttgagtgaa aaagagtttt tcatgagtag agccattaaa ctagcaaaac ttggatgggg 27001 aaaaaccaat cccaaccctt tggtgggggc ggttgttgtc aaggatggaa aaataattgc 27061 agaaggttac cacaagcaac tgggaggtcc tcatgccgaa gtggaggctt ttaacaacgc 27121 aaaggaggac gttgccggcg gcactttgta tgtcaatttg gagccatgtt cccattacgg 27181 caggacgccg ccctgtgctc aaaaaattat tgatgttggg ataaaaaaag tggttgcagc 27241 cataaaggac cccaacccga aggtttcggg cagaggtttt gaaatgctta aaaacgcagg 27301 aattgaggtt gaagtcgggg tacttgagga agaggccata agactcaacg aaatatttat 27361 cacttacatt gtaaaaaaga aaccttttgt aattttaaaa acggcaatga cattggacgg 27421 caagatagca acagcttcgg gagactccaa atgggtgacg ggggaaaaag caagaaatca 27481 tgtccatgtg ataagagaca gggttgcggc agtaatggtg ggaattaata ctgtcctgaa 27541 agataatcca taccttacca caagacttcc cgacaaggaa ggaagcgatc ctgtgaggat 27601 agttgtggac agcaaaggct caattcccct ggactcaaat gttataaatt ccaattcaaa 27661 agccggagtt atacttgcca ctacctcccg tatagacaag gaaaaggaaa aaatgctgat 27721 tgacaaagga gtaaaaatca ttaaggcgga cggcagtgac ggaagagtgg atttaaaact 27781 tctgatggat gaactttaca aacttgaaat tgacagtgtg ctgctggaag gaggaggtac 27841 gctgaacagc tctgccattt ccgcgggaat tgtggacaaa gtaatgtgtt ttatctctcc 27901 gaagatagtg gggggagaaa atgctcccac ctcggttgaa ggaatcggag cattaagaat 27961 gtgtgaagcc ataggagtaa aaaatatcag tgttgtaaag tttggggaag acatacttct 28021 ggaaggatat atagaatgaa agatattatt gaaagatata gtggaatgaa acaatataaa 28081 ataaaattta caggttaaat ataatcagga ggaaattgtg tttacgggaa ttgtagagga 28141 aattggattg gtaaaggaaa taattcctgg aaacaagtcg ataaaactca caataaaatg 28201 tgagaaaatt atggatgatg taaaagtcgg ggacagcata gccgtaaacg gaatctgtct 28261 tacggtcacg tctcttgaca acggtgcctt tacggcggac gttatgccac agaccatgag 28321 aaagaccaat ttgggaaacc tcaggacagg agaaaaggta aaccttgaaa gagcgttaag 28381 gcccgttgac aggatgggag ggcatattgt cagcgggcat attgacggta ccggagtgat 28441 attgtccaaa gaggaggagg acaatgccat ctggcttgag atttccgcac cttcggacat 28501 attgaaatat attgtggtaa gaggttcggt tgcattggac ggtgtcagcc ttaccgttgc 28561 atacgtggat gagaagagct ttaaagtttc tcttattccc cataccgcat cggttacaat 28621 attgggttca aaaaagcccg gcgacagaat aaatattgaa tgtgacatgc tgggaaaata 28681 tgttgagaag ctgatgtgtt tcgaccggca ggacaaaaag gaggaaaaaa agtctgtgac 28741 cttggatttt ctgagagaac acggatttgc ataaattcaa tacacaaaga agattattct 28801 gggaggcgtt tttatgaatt ttgatacaat tgagtccgcg atagaggaca tcaggcaggg 28861 aaaaatgata gttgtggttg acgatgaaga cagggaaaac gaaggcgacc tgctgatggc 28921 ggcggagctg gttacaccgg agcatatcaa tttcatggca acatacggaa gaggtatgat 28981 ttgcgccccg ataaccgagg ccagggcaaa ggaattggga ctggaattaa tggtaacgaa 29041 aaacagtgaa cacatgagaa ccgcctttac agtgacggtg gaccataaaa gcacgactac 29101 cggtatttcg gcttttgaaa gagctaaaac aataaaggaa ctttcaaatc ctgatgccaa 29161 accggatgat tttgtaaggc ctggacatgt ttttccatta attgctaaag aaggcggagt 29221 tctaaaacgt gcaggtcata ctgaagccgc agtagacttt gcaaaactgg caggacttta 29281 ccctgccggg gtaatatgcg aaattatgaa tgatgacgga accatggcca gagttccgca 29341 gcttatggaa tttgtaaaaa aacacggact taaacttgtt accatagcag atcttataaa 29401 atacagaaga aataatgaaa aattgataag aagggcggcg gaggcaaaac ttcccactga 29461 atacggggat tttaaaatag ttgcttatga aaacgttata aacggagaac atcatgtagc 29521 attggtaaag ggagatgtgg caaactccga cgagcctgta atggtgaggg tgcattcgga 29581 gtgccttacc ggggatgcgt tccattcctt aaggtgcgac tgcggtgagc agctgcacaa 29641 agccatggaa atgataggaa aagaggacaa gggagtactt ttgtacatga gacaggaagg 29701 ccgtggaatt ggccttgtaa acaaaatccg ggcgtatgag cttcaggatc agggaaaaga 29761 taccgttgag gccaatgtgc ttttgggatt tccccccgat cttagggaat atggcatagg 29821 agcccagata ttatacgacc tcggtgtaag gaaaataagg cttcttacca acaatcccaa 29881 gaagctgata ggacttggcg gtcacggact ggaaattgtt gaaagggtgc ccattgagat 29941 aaagggaaac gaaatcaaca gtttctattt gaaaaccaaa aaggaaaaaa tggggcattt 30001 attaaccagt ataaacacaa cggaacatca ggagggagaa tcaaatggca attaagacaa 30061 atgaaggtaa gcttatagct tcaggtttga agtttggggt ggttgtggca cgttttaacg 30121 agtttatcag cagcaagctc ttaggaggag tgattgacgg actgataagg catggagcgt 30181 ccgaagagga cattgaaatt tcatgggtgc ccggggcttt tgagatacct ttggtggctc 30241 agaaaatggc caattccaaa aaatttgacg ccataatttg catcggtgcc gttataagag 30301 gttcaacccc tcattttgac tatgtggcca acgaaatgtc aaagggaatt gcaaaagtat 30361 cgctggatac gggaatacca attgcttttg gtgtccttac cacggatacc attgaacagg 30421 ccattgaaag agcgggaacc aaggttggaa acaaaggcta tgatgcagcg gttacggcaa 30481 ttgaaatggc aaatttgcta aagatgatat aaagacaacg taagaagggt ctttgaagac 30541 aagacccttc ttttttgtct ggctttacag gtggcttttt atatgcagct ttatattata 30601 cacttatttt gtatcttgcg gtgtgtcatt ttgctcttct ttaaactttt taataaattc 30661 ttcctgttcc tttttcagaa gaatcagata tttctttaaa agattcggag tatgtacatc 30721 ggtataattg attttcaaac catattcgta attatactca tcttttactt ttcttatgat 30781 ggttgcttta agatgtatgg gaatatcggc atgaatgtca aacttgagct cctgaaacaa 30841 tggaaaatct tctttggtat gaatcatcat tccgttaaaa ctgatatttt tgacaattgc 30901 cagatatttt ttgttggact cgccgattcg agcttcggca tacagtgaca cgggaaatct 30961 cacgaaaagt cttttatttg aagttgtctc gtagttgtcg attttaagct ttagagtgtt 31021 ttgctgtttg tctacgttca aagttgtaca gctggagata taaacatttt cttctaattc 31081 acagcctaaa actatggggt caccaattga acaattgaga agagcgatgt cttccgtaag 31141 tttcagcaga acctcatcat tgtttgattc gagtaccagg cttttgaaaa gctttgtacc 31201 ggaaaaatga cgtatggata cgagatctcc aacttttatt tccatgttta tcactccatt 31261 aaaagaagtt tattgattta tttataaatt tgcaagttta ttgaacggac agcccaaata 31321 taaatcccga aagcctgtaa taactcctaa tgtgccaaaa gaccgaaaga gcaattaaaa 31381 tacattcggc aaatccagct gcagattgac gaacatgtga taaaaagacc aagtatttaa 31441 ttacattata acataattat aaatgattaa catatatatt ttattttttt aattttttat 31501 atataaacag caaaacaaga gagccaaaag aatatattta aatcaattta taatgaataa 31561 ttgaaaaaat gtgaaaaaag gtaaacttgc agaagcttat ttagcttatt taaaagaaaa 31621 atatggagac gaaaatttaa aaatggaatc tgacaaaaat tcagatgaca gggttctgcc 31681 cgggaaaatt ttgacgagtt aaaattttct tttaaatata tccttgacaa aaaactttat 31741 tccggttata ataactcttg caaattggtt gtgcgggttt aactcagtgg tagagtgtca 31801 ccttgccaag gtgaaagtcg cgagttcgaa tctcgtaacc cgctccagaa tgtatatcag 31861 gataacttta aacaagttat cctgataata aattaatcct ttatgaagaa aattgaaaag 31921 ataaaattta aagattgtgt tataagaagg ttttatatgc gggtgtagtt caatggtaga 31981 acatcagcct tccaagctga ttgcgagggt tcgattccct tcacccgctc caattgaagt 32041 tatgtacgca aagtggtaca taactttttt tatatttttc tcatcccaaa attattccta 32101 aatttaagaa tctcagtgaa aactttactg ttaaatgcat ttgtataaag gatacaaaag 32161 tgcaaatatt atatcttgat tttcaataat tattaaaata ttgcaagtaa aatattgaaa 32221 tattgtactt aaaatgatac aatgattacg taaattaatt tttcacagtt catttatgaa 32281 taaatgcaat ttttcttctt gttttattca aactctcttt gctgtacaaa tggagattgt 32341 gaatgttctt aagattttcc atgtttttag taaaaatatt acaaattaat tatttgcagg 32401 gaggtttgaa aaatgtcaag aaggggagct ttggttctgc ttgtgatttc gctgcttgtg 32461 actgcttttc tgccgacagc tgtttttgcc caggatgtac cattttccgg caaatcggac 32521 aatgtgccga gttttaccca accaataccc gtcaaacacc tttatgagct gatacacttg 32581 tgtatttggg aaagagggta tgatcgtttg gtagacttta attcagacgg ttcagtgaat 32641 tcgacagatc ttatgattct taacagggct gtgctgggtc tgggtggttt gcccgttcca 32701 attgagattg gcgattatcg tatagattaa accggtgagg gtttaatttt ataaagtgaa 32761 aattcaaagt gaaaatatat aaaagggatg gtgaataatt tgccatcccg tttttgtatc 32821 tttttagcca tgtttatttt attgctatga tataatataa tagattccgg atgattttaa 32881 tccgggattt tgcttgaaaa tattatgtaa agttatatta taaagggtgg ggaggagtat 32941 tttgtgtctt cagatgctgc ttattcggtt acgctaaaaa agctgcaaaa agctctttcg 33001 cttgagctgg ttaccgctga tgatgaagat agactggaaa atatcctggt aacatctcct 33061 gaggtgaaca ggcccggact tcagctggta ggatacctgg aatatttcgg aaccgacaga 33121 attcaaatga ttggaaaggt tgagaccagt tatcttgcgg ggcttacatc ggaggaacgc 33181 tattccaggc ttgacgagtt ttttaaatgt ggatttccct gcatggtagt ggccagaggg 33241 cttgaggttt tcccggaaat gctggaggtg tccagaaaat acggtattcc gattttcagg 33301 acgaaagaaa ccacatcaag agtattgagc gctttaatca gctaccttaa tgttgaactt 33361 gccgagagga cgagagaaca tggtgtgctt gtcgaggttt tcggagaagg cattctgata 33421 ttgggagaaa gcggtgtggg caaaagcgag acggctttgg aactggtaaa aaggggccac 33481 aggcttgtgg cggatgatgt agtggaaatc agaagagtgt ctgagaagac tttgtttgga 33541 accgctccgg atgaaataag gcacttcatt gaaataaggg gagttggaat acttgatgtc 33601 aaaaatctgt acggtgtggg tgccgtaaaa cctactgaaa atataaatct tgtaatacaa 33661 cttgagttct gggatcaaaa gaaagactat gaacggttgg gtttggtgga tgattacaag 33721 gagatacttg gaatcaatat tccatgcctt accattcccg tgagaccggg cagaaatctt 33781 gccattattg tggaagtcgc agctttgaac aacagacaga aaaaaatggg ttataatgct 33841 gccagagctt taaatgagag aatcatagga aaaggaagaa tgaggccctc ttatgaataa 33901 tttgcaggga tattgacgaa tggaggaatg gttttgaaat ttgtagttga cacacataca 33961 catacaatag ccagcggaca tgcgtacagc acggttcagg aaatggcaaa agaagcttcg 34021 gcgaacggca ttgaaatgtt tgcaattact gatcatggtc ctgccatgaa gggagctccc 34081 tatctttatc atttcggcaa cctcagagtt ataccggagg ttttatatgg tgtcaggata 34141 ttgaagggag ttgaggcaaa tataattgat tattccggtg ggctggatat gcccgaagag 34201 tatttaagga gacttgattt tgtgcttgca agttttcatg atatttgtat tgagcctaag 34261 accctggagg aacataccga ggctgtgata aacgtgctga aaaatcctta tgttgatgct 34321 attgcccatc cgggaaatcc ccaatttccg ttggatattg aaaaggttgt aagggctgca 34381 aaggagaacg gaaaatttat agaactgaac aatcactctt ttgttacaag aaaagggtct 34441 gaggagaatt gcaaagaatt tgcaagagag tgtaaaaagc aaggagtcag aatagtatgc 34501 gggagcgact ctcacataag ttttgaagtg ggtcgttttg acagggtata caagcttctc 34561 gaggaggtgg acatgccttg cgagcttgtt atgaatacct ccgttgagaa gtttgatgag 34621 tatataaaac ggaaaaagga gagaatcaga aggaaataaa gtgtaacggg cttaattttt 34681 gtataaaata ataattaaat tctatatatt gtgctggcag agtagaataa tagtatggag 34741 tgcaaaatag tttggtaagg agctgacatt gttggaaaaa gagcttttgg caagggagat 34801 tgaaaaaata gccggtcagg aaaatgttaa acttgatgag cctatgaaaa accatacttc 34861 gttcaaggtt ggcggaccgg cggatattct ggttactccc gtgtctgttt cgcaactgag 34921 tcaaatttta aaattatgca aaaacaaaag cgttccggtg tttgttatgg gcaacggaac 34981 aaacttgatt gtaagagata aaggaataag gggagtagtt gtaaaaatat tcgacaatct 35041 aaatcaattt actgttaaag acgatattat tactgcatat gccggtatac tcctttccag 35101 ggtttcaacg attgcttatg aaaacgggct tacgggtctt gagtttgcct gcggcatacc 35161 gggtactctc ggaggagcgg ttgccatgaa cgcgggagca tacggtggag aaatgaagga 35221 tgtcgtagtt gaaaccgaat acatggataa agacggtgaa attagagttg taagggatga 35281 cggacaccaa ttcggataca ggaccagctt tatccagaaa aattccggca tagttataaa 35341 gacctcaatg aaactaaaaa aaggaaacaa agaagaaata aaggccctga tggatgattt 35401 gacccaaaga aggcaggaaa aacagccttt ggagatgccg agcgcaggca gcatttttaa 35461 aaggccggaa gggtattttg caggaaagct gattgaggac tgcgggcttc gcggacaccg 35521 cataggcgga gccgaggttt cgcaaaaaca ctgtggtttt attgtaaata caggagatgc 35581 aaaggccaaa gatatattgg atttgataga atatatacga aatactgtaa agatgaaatt 35641 tggggttgat atgcagactg aagtgagaat tgtcggagag gtgtaataat tctcaccggc 35701 agtcggacat tttgggaggt acaaatgaga ttactgataa ttacgggaat ttcaggagcc 35761 ggtaaaagtc ttgttgttaa atatctggaa gatataggtt tcttctgcgt ggataatctt 35821 ccgcctctgc tcataggcaa atttgccgaa atctgtctca aaagcagggg aaaaataagc 35881 aaagtggctc ttgtcataga tattagaggg ggagagcttt ttaacgatct tgttcccgaa 35941 ctcaatgctt tgaaagagtc gggaattgat tatgaaattc ttttccttga agcatcggat 36001 caagtgctta tcaaaagata caaggagagc aggcgtattc atccgcttgc tcctgaggga 36061 agactgatta agggtataaa aaccgagagg gaaattttgt cgcagattag aaaaaatgca 36121 acttatatta tcgacacgtc aaatttaacg ccaagacagc tgaaagaaga gattctggcc 36181 atatttgtcg agggcaggaa atttgacgga atgatagtaa atattatctc ttttggcttt 36241 aaatatggta ttcccattga atgtgacctg gtctttgatg tgagattcat tcccaacccg 36301 tattatatag agagtatgaa atataagacg gggaaggatg aagaagtcag aaattatgtg 36361 atgagttttg cggaaactgc tgagtttatg acaaaactta aagacttggt ggattttttg 36421 ataccgaatt atataaaaga aggcaagtca cagcttgtga taggagttgg gtgtaccggc 36481 ggaagacata gatccgtcgc tatttccgag gcattgtttt cgtatctttg tggcagggaa 36541 cacagggtgt ttattgacca cagggatata gacaaagatg gcaggagtaa tcgaagatga 36601 aaaatgataa ttggtttaga aaaaaaattg caggataccg atggtgtctt ttgatcgttt 36661 tcgggattat actgattagt gcgggcatgc ttttggcata cagacatgac aatacttttg 36721 acatcttttg ttctgtactt ctttttgcgt caggatgtat atttattgtt gtttcgatac 36781 ggcttattgc aattgacacg gtgtcaaaat acgcccaaaa cggtataaat gtagtatgct 36841 gcaaagacag ggacgataat ttgtatgaaa aagaatttct tgacaaagga ccgaaaatag 36901 ttgcaatagg tggaggaacc ggactttcaa ccatgctgag agggcttaag gaatgcagct 36961 cgaatataac ggccgtggtt acggttgccg atgatggggg aggctccggg attctaagac 37021 aggaccttgg gatacttcct cccggggata tcagaaactg tattttggcc cttgccaata 37081 ccgagcctat tatggaaaaa ctgcttcagt acagattcca ggacggaatg ctgaaaggac 37141 agagttttgg aaatctgttt cttgcagcaa tggatggtat ttcttcgagt tttgaacagg 37201 ctgtccaaag aatgagtgat gtacttgcag taaaagggag agttcttccg gttacgcttg 37261 aggacattca gctgtgtgcg gagctggaag acggatatgt tatcaccgga gagtcacaaa 37321 ttggcaatca taacagcttt caccgttgcg caatcaagag ggtgtatttg gaacccggaa 37381 aggtaaaacc cctggatgag gtgatagaag caatcggaga agcggatgta attgtgttgg 37441 ggccgggaag tctctttaca agtataattc ccaacctttt ggttgacggt gtgtgtgatg 37501 cgataaaaaa atcaaaggct ttgaaaatat atgtgtgcaa tgtcatgacc cagccggggg 37561 aaaccgacgg atatagcgtt tcggatcata taaaggcact tgaaaggcac tcttttgagg 37621 gaattgttga ttactgcatt tttaacactg ctgatatacc tgaactattg aaaaagaagt 37681 atagtgagga cggagcacaa attgtcagag ttgactatga tgagttggat aaattaggca 37741 taaaattgct gggaggggac tttgtctgca taactaacgg atatataaga catgatacaa 37801 agaaattggc tcaggccatc atgaaccttg ttattgagaa tgtatttgga aaagacgaca 37861 gaaaatcatc cggttatgta aatacaatga agcaatttaa aaatatagtc ggataaaaaa 37921 cataaaatac ggaggaatga tcatgaactt tggaaaatcc agctggagaa cttatgagca 37981 agggattcaa cgggaatggc ttctaaccaa cggcatagga ggatttgcat catccacgat 38041 tataggttcg aacacccgaa ggtaccatgg tctgttggtg gcggcactga aacctcctgt 38101 aagcaggcac ttgatattgt ccaaaattga tgaatgtgta actgttgaca atgaatcgtt 38161 caatttgttt tcttatgaag tgccgggttt tataatgcat ggatatcatc atctggaacg 38221 atttgaatat gatatgcttc ctaaatatat atatagagta aaggatgtat atgttgaaaa 38281 ggaaatatgc atggtttacg gtgaaaacac cgttgttgtg gtttaccacg tcataaacgg 38341 gaccggaaga accaatttga gacttactcc tcttgtgaat ttccgggact atcattttaa 38401 ctccggcaga gcatatatga gttttgaaag aaaatttgaa aaagatgttt taacggtgcg 38461 accttcctgc tacgacattg acattaagct gtactcaact gatgggaaat ttacggagct 38521 tgacgatacc tggttttaca acatggatta tgctgtggaa agggaaagag gtttggcctc 38581 caccgaggat cattatatac ccgggtatta tgatattgaa ataaaacctt tggaggaaaa 38641 atacataacc tttgtagcta ccgtcgaaaa aaacgtaaat cacagagacg ggcttaaaat 38701 aatagaaaaa gaaaaaaaga ggcttaaaaa actggcaagt aaagcgggat acaaggatga 38761 gctggcaaaa aaactggttt tggcggcaga caaatttata gtacacaggg aatccactaa 38821 tgcgaaaacc gtaattgcag gatatccgtg gtttacggat tggggaaggg ataccatgat 38881 atctcttgcg ggacttacgc tggcaacccg gcgttttgag gatgcaaagg agattcttta 38941 tactttttca aaatatgtca aagacggact tataccgaac atgttccccg atgcgggaca 39001 tgagccgccg tacaacaccg ttgatgccgc tctgtggtac tttgaagctg taaacaagta 39061 tgtaaattac acccatgatt ataagttcat aaaagaaaat atatacagtg gattgaaaca 39121 gataattgag tactactcaa aaggaaccca ctttaatata aaagctgatg aggattattt 39181 aatcagtgcc ggagatgaac atacccagct tacatggatg gatgcgaaag tgggtgactg 39241 ggtggttact ccgcgtcatg gaaaagctgt ggagataaat gctttgtggt ataatgcctt 39301 aaaaattatg tcgcagcttt cgaaacattt taaagaagat gccggattat acgatgaaat 39361 ggccgaaaaa gtcaagaagt cttttgaaga gaagttctgg aatgaagaga aaaaatgtct 39421 ttatgactgt cttacaccaa attataaaga tgataaagta aggccgaacc agatattggc 39481 tgtaagtctt tcctatccgg taatagaagg agaaaaggca aagagtgttg tggatattgt 39541 ttttaaagag ctctataccg cttatggctt aaggagtctg tcacctaaag aaaaggaata 39601 tgtgggagtg tatatgggtg atcaatacag aagggacgga gcataccatc agggcacggt 39661 ctggacatgg cctttgggcc actttataac tgcgtatctc agggtaaaca attattcgcc 39721 ggaggccagg aaaatggctt taagatttat tgagcccttt aaggaccatc ttcaggatgc 39781 ctgtcttggt tctgtttccg agatatttga cggtaatgag ccgttgatac caagaggctg 39841 ttttgcacag gcctggagtg tggcagagat actcagagcc tatgttgagg acgtgatgca 39901 gttggtacag ctaaaacact agaaatttct tgcgatatgg gttataattt ctgtgcgatt 39961 tgtaattttg gaaaaaagta atatttttag tatggggtgt ctgcattgtc gttttcatcg 40021 gcagttaaaa atgagttgtg cagagttgaa acagatcgca gcagcagttt gtttgaactt 40081 gcggctgctg caaggataag cgggcttata aaggttgtta acgccaatga gattaatctg 40141 aggcttgtaa ctgaaaatgc agcatttgcc cgcaggatat tttcacagat caaggatttg 40201 tacggcataa atgctgaaat aagcataaga agaagcccaa agctgaaaaa aaatattgtc 40261 tatatcattg tgctgacttc atcgaaaggt ttgatgagaa tacttgagga tattaatatt 40321 aaagtatccg aaaaagtgga atacataccg tatgcccggt gtatgaggaa gaaggaatac 40381 agaaaggcgt atcttagggg tgcgttttta gcttccggct caatgagcga tcctgaaaaa 40441 acatatcatc tggagataac atgccacaat atggctttgg cgactgaagt cagtgatttg 40501 atggacagtt ttaaattaca ttcgaaagtt acaaaaagaa aaggaaacta tgtggtttat 40561 cttaaagaag gggagaacat agttgacttt ttgaatataa tcggagcaca ttctgcgctt 40621 ttggagcttg aaaacatcag gattttaaag gaaatgcgca acaacgtcaa cagaatagtc 40681 aattgtgaga cggcaaattt gcaaaagact gtggatgctt cggtaaggca ggtggaaaat 40741 atcaactata taaaggagca tcttggattt gacaaattgc cggaaaatct cagagaaata 40801 gcaaaaatga ggcttgccta cagtgatgca actttaaagg aactaggaga aatgttaaat 40861 cctcctcttg gaaaatccgg agttaatcat agattgagaa agttggacaa gattgctgag 40921 agcttaagaa acatgaaagg agagttatga aaatggttga gaaaactgtt gtgataacta 40981 atcccgaagg actgcatgcg cgaccggcag cactttttgt gcaaactgcc ggaaagttta 41041 cttcgaatgt ctggattaag gttgggaaaa caaaagtaaa tgccaagagc ataatgggac 41101 ttatatctct ggctgttgca cagggcaccg aggttgtaat aggtgctgag ggagaagatg 41161 aagaaaaggc tgtggaagag cttattgatc ttgttacaac aggttttacg gaggattaac 41221 tcaaaaaaca aattgataaa atagagaata tcgacaaacc atataagatt ggcattttag 41281 tgttgatttt tgatatggtt tgtcgatatt tttttggcct tattacaaaa ctttacaata 41341 ttctttgaag ggggaaataa tattttgaag aattaaggtt aggataactg acagtggagg 41401 aggataagct tgaatataaa attgacaaac aggggcaata ctttggtggc ggtgctaaat 41461 ggtgaactgg accaccatac cgctgaatac ataagacaaa aactggatgc tgaaatgatg 41521 aaatccacaa ccaaaaacat ggttttggat ttttcgaaag ttacttttat ggatagctcg 41581 ggaatcggag ttatcatggg aagatataaa aatatacgga agctgaacgg aaaaatgtct 41641 ttagccggta ttaatgacaa gataaaacgc atttttgaaa tgtcgggact cttgaaattg 41701 atgccggctt atgacagcat agatgaagct attaataaaa tgtaaagggg tataaagaat 41761 gaatccaata aatgaggtta gactggagtt tgtcagcaaa tcaagtaatg aatcatttgc 41821 cagagttgtg gcggcggctt ttgtatctca aatagatccg aatttggagg aacttgcgga 41881 tgtgaaaacg gcggtttccg aagccgtgac aaatgcaata attcatggat acgaaaacga 41941 gcctggtttt gtaaaaatga ctttaaagct ctatgaagat gccgtggaga taagcgtaac 42001 cgacgagggc aagggcatag aagatataga aaaggcccgg cagcctatgt atacttccag 42061 gcctgacatg gaaaggtcag ggatgggatt tacagtcatg gagagtttca tggacagggt 42121 tgacgttgtg tccgaggtgg gcaaaggcac aaccgtaaca atgttcaaaa cttttaattc 42181 tgtgaggggt agaaaaaata ccccgtaaca tagaacaaat acctgagagg atatggggat 42241 gaatatggac gaattgcatg aaaaggaaac tctggaatta atagcagctg ccaaggcagg 42301 agacaaagat gcccaatccc tgttggtgga aaaaaatgtt ggtcttgtat ggagtatcgt 42361 gcgaagattt caaaacagag gatatgaagc tgaagatatt ttccaaatcg gatgcatagg 42421 acttattaaa gccataaaca agtttgactg ctcatacgat gtcaaatttt ccacctatgc 42481 ggttccgatg ataattggag aaataaaacg ctttattcgc gatgacggaa tgataaaagt 42541 aagccgttct cttaaggagc tggcaaataa agccaggatc accaaggaaa ttatgtcaaa 42601 ggaattgggg cgggagccga ctgtcggtga aatttcggag cagctcggca ttcccgttga 42661 agaagtggtt atggcaatgg aggcaagttg tactcctgaa tccttataca gtacactggg 42721 agagggagac aattcctcca cccttcttat tgataaaatt gcaaatgaaa gcgaaaacca 42781 ggaagtggac attgtagaca gaatcgactt aagaaaggta ttggatactt taaagccacg 42841 ggaaaagcag attattgttt tgaggtattt taaagaaaaa acccaggttc aaattgcgaa 42901 aatgctgggg atatcccagg tacaggtgtc aaggattgaa aagaagatat tggaagagat 42961 ccgaaaaaaa ataaaataca attaaacttg attaactgat aaaacatatt tttaaacgta 43021 tatttttgat gatgctatat aaagcaatat gttcctgcat attgtttttt tatttcctaa 43081 taataaataa aaatactttt gtatgataaa gtttcagaaa aggttccaac gtacaaaatt 43141 tatagtataa ggggactggt tttgaatatg actgaagtgc tgagaaggta caaaatgatt 43201 ttaataattt taggcctttc tttggtgatt gcatttttga cttttgctat ttttgtgcaa 43261 aaacctgaga aagttccttc aagaggaatt ttcgtttttg agaatactac tgatgaaaaa 43321 agctttataa aggtattgac agaaaaaaca ctttaacaaa agctggaggt ttcgtatgca 43381 gaaaacaatg accaacaaag agtaccaggc gtatgtggaa aaaaagactc ccaattcaaa 43441 aacagggaga aatgtactta gagctttttt gatcggaggc ctgatttgta caatcggcca 43501 gtttataacc aatgttttaa aaatgatggg ttacggacag gaacaggttt cctcgatagt 43561 atcgctcata atgattttta taggagcact tttaaccggg cttgatattt atgatgacat 43621 aggaagatat gcaggcgccg gttccattgt gccaataacg ggctttgcaa attcaatagt 43681 ctcaccggca attgaattta aaagcgaagg gtatgttatg ggggtgggag caagaatgtt 43741 tgttgttgcc ggtccggtat tggtgtatgg gatttcaaca tccatagttg caggaattat 43801 ttactttctt ttaaaatagc aaaactactg tttaattaaa tttactatta attgttaata 43861 atggagagga gtgaattatg gcatcaaaaa gattgggaaa acaaacagta atgcttcaaa 43921 atccgccaag aattacttca acggcttcaa tagtgggtcc aaaagaggga aagggaccgt 43981 tgaggctctt ttttgacaat ataattgaag acgaaatgtg gggagaaaaa agttgggaaa 44041 aggctgaaag caaactgatt agagagactt tttccaaggt tttgcaaaaa ggaaacaaga 44101 caagccagga aatagattat gtaatttcag gagatttgct taatcaatgt attgccgcca 44161 acttcggact cagggaatcg gatgttccgt tttttggagt gtatggtgcc tgttccacta 44221 ttgcggaatc aatgagtatc ggagcaatgc tggttgacgg agggtttgcc gataacgttg 44281 tatgtataac gtcaagtcat ttttgctctg cggaaaaaca gttccgtttt cctttggagt 44341 tgggaacgca aaggcctcct tcagcccaat ggacggtaac cggctccgga ggagtgttga 44401 tttcaaacga tggttcaggc ccgtatatta cacatattac caccggcaaa attgttgaca 44461 tgggaatcaa agatgcaaac aatatgggag ccgccatggc acctgcggct gttgatacaa 44521 tagttaccca ttttaaagat acgggattta ctcctgaaag ctatgacctt atattgacag 44581 gggaccttgg tgccatagga agggaaatat gtgttgaact tacaagagaa cagggcttca 44641 atattgaaaa tatatacaat gactgcggtc ttatgatata cgaccgtgaa aaacaggaca 44701 cacatgccgg aggaagtgga tgcggctgtg cggcaactgt gtttgcgggt tttgtttata 44761 aaaagcttat ggacggaact ttgaaaaatg ttttattcgt tgccacagga gctttgttaa 44821 gccctgtaag tacccagcag ggagaatcga taccttccat agctcatgca atcagcatta 44881 caacgtcacc tgaacgatag gtacggtata aaaagtgcta ttacttattt tgaggtggtt 44941 gacatggata atactataat gacatatata agtgcgttta ttgtcggtgg agtaatttgt 45001 gccgtggggc aaatactgat tgacaaaacg aaacttacct cggccagaat ccttgtgctg 45061 tttgtatctg caggtgcggt gcttacggcg ctgggagttt accagaaact ggttgacatc 45121 gggggcgcag gagccaccat accgcttaca ggatttggtt acaatcttgt aaccgggaca 45181 ttcaaggaag ttgacaaact ggggattctt ggcgcgttta caggcggagt aagagccgcg 45241 gcagccggaa ttgcggcagc gatatttttt ggctatctta tgtctgttgc gtttacacct 45301 aaagcgaaaa gatagctgta ataatgaaac aggacagttg aatatattct tgaaatttta 45361 gtcagacttg tttgaaatgt gggtatggat aatgaataaa agaaaagtta ttattgttac 45421 cgatggtgat atggcagcaa aagcagccgt ggaaattgcc gctttaaata tcggagggga 45481 atgtatttcc tattctgccg ggaatccgac tgttttgacc gggcaacaaa ttgttgaact 45541 tgtaaaggcg gctgaaaaag atcctgtggt ggtaatggtt gatgacaagg ggtataaagg 45601 caaaggcgcc ggagaagctg ctatggaagt gcttttgaac aatgatgata ttgaagtgct 45661 tggtgttgtt gcagtatctt ccgacggtaa agactgcaac gggataaagc tcacttgctc 45721 tgttacaagg gaaggaaaag tgattgaagg ctcagtaaac aaaaaaggaa ttgccactcg 45781 aaacggcaaa atctgcggag ataccttaag tattttgaga gggcgcaaag acttggtcat 45841 tgtcggaata ggagacccgg gaaaaatgga tttttatgat tctattgaaa aaggtgctcc 45901 tataaccaca aaagcattgc aggaggtact aaaaagaagt gctgcaaggc actagtgttt 45961 tgccgtacgg ctttgtgcct gttgcatctg cctgttccat ccggagaaag tgaaaggtgg 46021 tatttcttat gaatgttgaa tacattaatc cctttataga agcaagtcgg gctgtattaa 46081 agcaaatcgc gggaatagat gtgaaattgg gcagtatttc tttaaaaaat tctccttatg 46141 ccagtgataa tatagtaatt ttagtaggtc ttacaggaaa aatcagagga caggcaattt 46201 tctccatgaa taaaaacgtt gctttaaccg ttgcttccgg tatgatggga ggccttaatc 46261 tgacggaatt ggacgaaatg tcaaaaagcg ctttgtcaga acttacgaac atgattttgg 46321 gcaataccgc cacacttctt tataacagag gggttggcgt tgaaataact ccaccgtctt 46381 ttctgatggg ggagaacatg cagatttcac cttcaaaaat gaagacaata tgtattccgc 46441 ttcttttggg agaagataaa aagattgagt tggatatttc agtggttgat taaccttttt 46501 gcataattta aaatagagca tagcagagtt tgctgaaaac aagttctgcc gtgctctgtt 46561 ttatgtttgg agcaaaagtt tgccgaaaga aataacagat aaattggaaa gggagaaaaa 46621 caatggcaat caatgttgta ctggtggagc ctgagatacc ccaaaacaca ggaaatattg 46681 caagaacctg tgcggcggtg ggggctaatc ttcatttggt caagcctttg gggttttcag 46741 ttgaggacag atacttaaag cgtgcaggtc tggattattg ggataaagta aatataaagt 46801 attatgacag ttttagtgaa cttagggata aatataagga gcacattttt tattattcaa 46861 ccacaaaagc acaaaagtta tacaccgatg taaaatatcc tgatgattgt tttattgttt 46921 ttggcaaaga aacggcgggt ttgccggaag aactgcttgt ggaaaacaag gaatggtgca 46981 tcaggattcc gatgagagat gatatccgct ctttaaatct ttcaaactct gttgccataa 47041 ttgtatatga agcattacga cagaacaatt ttgccggact tgtgccttat ggaaaactga 47101 ctaaatatac atggtaattc gaacacttga ttatatgata taatggtaaa attataaata 47161 aagaagtatg ttatcgaaac gctcttggct gttctcctgt taccggacca ttttctgtaa 47221 tataattaaa atagtattga ttttggggtt atgttgttat taagatatac aggaaaatat 47281 ttaatttgaa tgttttttct ttaatggttt cttttattcg atgtttgtgt ggaaatattt 47341 cgaatactga agtataatat atagatataa taatagatat atagagatga taatagatat 47401 acagttatta tgttgacatt ttaatgacag tttatttagg tggttggatg ttatgaacaa 47461 acatgtttca ttgctcagga aaagatatgt tgatttgcgg gatacatatc ttggcagtga 47521 gctgaaaaaa gttgagttgc ttttttatat ttcggtttcg atagcattgg ggcttataca 47581 atataagctg ctaaattatg aaaatacata caacattcga gcttatatca gccatataca 47641 atcatgcatt gtgattctta tggcctttcg atttggctat gtgggactgg ccacggcagt 47701 ggtattggtt ttggctgaaa caatattcat aattgaagaa tatttggtca gtttcgataa 47761 atatctttta cttgggctta cgctgaaatt ctttacaata tttgtaacca gttttattgc 47821 agtacttacc aacaggcagc agattcagaa gaaaaggctt gaacggatgg caattacgga 47881 tgaattgacc ggggcataca atcagagatt ttttcacatg gtgcttgaaa gtgagcttga 47941 gaaggcaaaa aataataacg gttctgtgag ccttataatg attgacatag ataactttaa 48001 aatgtacaac gatatttacg gacgtgactt tggtgacaat atattgagga caactgcaac 48061 aatcctttcg gaaattttgg acgaaggcag ctatttgtgc cgatacggcg gagatgaatt 48121 tgctgttatt actacaaata cccggctcga taatttagag gatatggcaa acaatcttcg 48181 ccgggagttt gaaagactta aacaaaaata ttacaaacat aaattatacg aaaaggtaac 48241 actgtccatt ggtttgtcgg aataccccaa catgtcgcgg gacaaaaatg aactcattta 48301 ccaggccgat acagccttgt atcatgcaaa gaacctggga aaagacaagg tacatctcta 48361 tcaggacgcg ttaatgcaaa tacgcaaaaa tatcagttcc gaccaccagc agcttatagg 48421 aatattcaag ggattgttga gtaccatatc ggcaaaggat aaatatactc atggacattg 48481 cgagcgggtg gcggcttatg cggtgctgat tgcggaggca atgggactga gtgcaaaaga 48541 aatcagcaca attcagtgtg ccgctttgtt gcatgacatt ggaaagatag aaatgcccag 48601 gcacatatta aataaaaaag aagaactgac tgaagaggaa ataaaatatt taagacagca 48661 ccctatatat agtgaaaaca tacttgagcc tttggcggac atggacaagc ttaccgatta 48721 tgtaaggcac catcatgaaa gatatgatgg caagggttat ccggacggcc taaaaggtaa 48781 ggaaataagc ctcggtgcca gaatattgtg tgttgcagac tcttttgatg ccatggtgtc 48841 cgaccgcccg tacagtaaaa gcatgtcaaa ggaagatgct tttaaagaac ttgagaaaaa 48901 tgcgggaacc cagtttgatc cggaaattgt agagattttc ataaaagcaa tgaaatcgta 48961 tgccgcataa attaagtaaa ctgtggctga tatatgcccc cttgcctaat ttgtcgtttt 49021 ctggtttttt acagagaaaa caaacaaaat attgaaaaat atgttgattt attggtaaat 49081 taattgtaaa attaatacat gggattgttt ctcgatatta ttagtttgcc ataaagccga 49141 cagaggaata ttttgttatg gtatgagggg gactatgact gaattatttt attttccaaa 49201 gagaaagaag aaaactattc gcagattttg caagatattg tctaccgatt cttatattcc 49261 tgaaaaagtt gttgaaaatg aggaaataat agaaaaatat catccgtcct ttaaaaacga 49321 ggtgattgtg aaaaccatag gggtggaaag aaggcacatt gcggaaaagg acgaggatga 49381 cagcgatatc cttgcaaaat cggcaagagg atgccttgaa aaatacggga tattaccgga 49441 tgacctttcg agaattattg tgaacaagtt tgtgggtgac aatttcctgc ctatgacagc 49501 aagccggctt cagggtaaaa ttggaagcaa gacggccgta catgcctttg atattgacgg 49561 aggaatttca tcttttcttt attcgatgga tgctgcgtca agatttatca attccgggga 49621 tgaatatatt cttatttcat cgggaggcgt aatttcaaag tttgtaagca aggccgatcc 49681 cagggttgcg tttttgtttg gagatgcttc agcctcggta cttttgggtc attcggaaga 49741 aagacatata ttggcgagtt atttttattc caactgtcac tattatgaca tgtttgtaat 49801 gctaagtcct ttaagtttgg ccaagttttc ccgggaagag ctttcaacgg cggtatggga 49861 tttatacaag atggagaact ggaaaacggc tgaaagcttt tacagggagg cagtaagaga 49921 agtatcaaag aatcttcttg aagagagcgg ccttacgatg aaggacatag atttggtttt 49981 ggttaccgaa aacaacataa aaatatggga attgacattg gagactttgg gagtaaatgc 50041 cgacaagagt atttctttaa tcagggaata tggcaatacc atgtcagcta tgctcccgct 50101 tcttatagat catggatttc gtacggggag aatagaaaaa gggatgaata ttatgatgat 50161 atcccacgga gaaggattca gcggcggagg acttgtatac agagtctaat cttaaatatg 50221 ttgtcagatt atacaaaaaa ttgatgtaaa atagaattgg atatgtttat ttacaagttg 50281 cttttttaca agtcatacta tttttacaag ggggatttac tatgaactac gatgaaatct 50341 atgacaaagc aaaacagatg atagctgaat atttaagagt tgatgagaat gaaattactc 50401 ccaaaacaaa tcttgtcgat gacctttgcg ccgactctat tgctttggtg gagttgggat 50461 tcagattctc cgagactttt tcggtaccta tgatggaatc taaaccggat atgtttatta 50521 tggataatat tgttagattt ataatggaaa agaccggcga taaataatcg gcatttatta 50581 cgctttagta gtcattatat atatgctgtt gttttgcaaa aacatataca aattaatacc 50641 tttcaatata atttcaggtt atatttatcg ctttttacca caagcaacgg ataaaaatgg 50701 gggagactat gaataatgat attagatttc cggaaataaa gccactgaaa atagagagat 50761 atgcaaaaat agtttctaca ggcgttggac ttcctgaaag agtggttact aaccaggata 50821 tcattgatga atacgatatc attgcaacgg acagggcggt aaggtattcg gtgggcatag 50881 ttgaaagaag atgggttact gacgaaaagc ttgaagatct tgtggcaatg gccatttccc 50941 agtgtcttga aagagcgggt ctggatattg acagtgtgga caggattata tattcgcggc 51001 ttttgggtga ctaccaggta ccggccactt ccataggtgc tctcagaaaa ttgggtgcaa 51061 aagttgggat accggctttt gatatgacct gtgcctgcag cgggtttatg catgccctgg 51121 atcttgcaat acggtatatt gattccggtg atgattatat cattatcctt ggaggaggca 51181 taacttcaca aggtattcag atatggaaac agccaaatca gaaaaccata tttttgtttg 51241 gtgatgcagt agttgctgtg ttaatcggtt attctgaagt taagcatttc ctggcttctt 51301 atcttatgac caatcacctc ctgtacgata atgcttttat tccgtttggg acaacccttt 51361 ttaaaaacga aaatgtaaaa atcgagcccg agctgttcaa catgaacgta ataaacgggg 51421 atttgattct tgaaagctcc gttgaatatt gcagaatgat aacggacaag cttttggccg 51481 aaactaattt gactttggat gatattgatt tttttattac atcggatcaa tcaacaaaaa 51541 tatgggaggc acaagtaaaa gaattgggaa ttccctttga aaagagcctg agtctgttct 51601 acaagtacgc caatacggtt gcggcaatga gtccgttgat tcttcatgag cttattacat 51661 cgggacggct taagagagga gaccttgtaa tgatgcatgc tcatggagca ggcgcaagca 51721 gcgggggaat gatatttaga tactaaagat aaaaacataa cagatactta ggggggaagc 51781 taaaatgaat tattgcaatt ggttgtttga cacaaaagac aaggaccttg aaagagaaat 51841 catcattgac tgggaaaccg gaaaaaggct gacttttaaa ggacttcaga cggaagtggt 51901 aaggcttgca aatttcctca agtcaaaagg gtatgtcccc ggaacggtta ttgccacaca 51961 tctttacaac ggtattgaag cagccgtcgc ttttttggcc gccgaatata tcggatgtgt 52021 tgtttgcctt gtggatccgc tttttaaggc ggacgaagtg ccgtactatg ttgaagactc 52081 cggtgccaaa tgtctaatta cccacctgga aaaagatgag atagccggaa aactaccatc 52141 ggaagttgat gtgataaacg taagagaggt tcaggaagtc tgtgaaagcg acgagtttga 52201 aaaatctctt gaaatatatg attttgaaga aaatgaactt gcactgcttt tatatacctc 52261 gggttccact tccactccca agggtgtgat gcttacaacg ggctgttgtc atacgttcct 52321 tagaaagaat catcagtcga tgtacagata tgatccggat gacagaatct tatgttttgt 52381 gcccttttcc catggattcg gttcaatttc cgtcctgatt ccggcattgg cgtacaaggc 52441 gggaattgtg tttcaaaaaa cattccatcc tgccaaagtt gccgaagcgg tgataaaaga 52501 gaacattacc catatgctgg gcgtgccgac ccattaccgt caattgttaa gatatgaacc 52561 tttcattaac aatctgggca agcttaaagc ggctttttgc tcggcagcgc ccattagctg 52621 tgaagtggca cggcagtggt acgaaaaaac cggaatatat ttggatgagg gctacggaat 52681 gagtgaagca accactctta ttaccacaag gatgtcacgg cttccttcaa cttcagggga 52741 tgtgggacac cccccggaag ggattatatc cgttgacatt gttgacgaca acgacagggt 52801 ggttgaaaac ggaacaatag gagaaattcg tgtaaccgga cagggactca tgcttggata 52861 cctgaatcgg ccgaaagaga cagcggaaag gctcagaaac ggatatctct ataccggtga 52921 tttgggatac aaaaaccctg acggatcact ggttgtttgc ggcagaaaaa cagaattcat 52981 aaacgttgca gggcttaaaa tatcgcctgt tgaagttgag actgcattaa attcccattc 53041 ggatgtgatt gattctgcag ttgtcggagt tacggatgaa gtctatggag aagtggtaaa 53101 ggcttttgtt atcaagaaac aggattcaaa cctcacggag cgggaactga taaaatatgt 53161 ttccgacaaa gtggcaaact ttaaagtacc gaaatatgtt gtgtttgttg atgaatttcc 53221 gcgaaacaat gttggaaaag ttgataaaaa ggcattaaaa aatatgtagc atgcaaaggg 53281 tgttttgtta tgaatgaagc aagctcgaaa tttgtggata atattgctat tgagaaactt 53341 ctcaatgaaa aacttcttag agtttctcac agacctaaaa atttgtttta tgatgatgaa 53401 aaagtatttg acgacctttg caagtgtgaa acggatatgt caaaagttaa acttgcagaa 53461 ggggataaaa acttaaaacg ttttgaattt ccgtcttttc tgaagacaga ggaatatatt 53521 gaaaacaata ctgtgtatct ttattatcat cctgcaaaag atccggtatg caatattttg 53581 ttattgcatg gcttgtatga tgataatatg cttaattacg gatttttaac aagaatgtta 53641 aacgaactta agttcaacgt gtttcttatg gaattgcctt tccattttaa caggaaaccg 53701 gcggaaagtt ttttcagcgg agaatatttt ataagtgcag atcttttgag agcccgcaat 53761 gcttttattc aaagcattta tgatattgag gcttcccgga accttattgg aaatatcaat 53821 actttgccgt gtttgcttgt cgggtttagc atgggagggt gcatatcttt caggtatcac 53881 atgctaagag acagttttaa gggaactttc ttaatcaacc cggttacgga tatgctgttg 53941 ctggtatggg acaatccgct gctggttaag attaaaaagg acctcgagga cagcggtgtg 54001 ggaaaagaac aagttatgga cgtttttaga attatagacc cttgtgaaaa tattaacaca 54061 aggtttaata ccgacaatat tgcggttgtg tattccatat atgatcaaat tgtgggagag 54121 gaaaagaacg caatatttgt tgagaaaatt aagaaagcgg gtttgaagaa aatacttgaa 54181 tatcatgcgg ggcatctgaa cattttgaga gtgccgaagc tttccaatga tatttatgag 54241 ttttttatga gttgcctgtg agtctgcaag acacagagaa atataattta tttgtgggga 54301 ggttatacta tgaagaatta cttttatccc gaagaaagaa tagcaatcgt cggaatggga 54361 gcgttgctgc cggatgcaaa caatgtcgat tccttctgga acaatattct cagcaaaaaa 54421 gtttccataa aagaactgcc ggaaagcatt ttaaatccgg atatatatta tgaccgcgat 54481 gcttttggaa aaatcaacaa aaacgacaaa acttacacca gaatggtagc taaagttgat 54541 gtggatgatt acccttcgct aaccagaaaa ttcaaaatcc cccctgcggt ggcagaacac 54601 atggatccaa accagcatgt ggcaatttac tgtgtggacc aggctttgca gtcccttgca 54661 aacagcaaca taaacaggga gcgtacggct gtcataatga atatcggagc tccgggaatc 54721 cggtacaaca atataataag gagaacctat tatgcaaaga tagagcatta cctgcgtaac 54781 aacccgaaat tgaatgaaag cttgaaaaaa gaggaattgg atgaggtgct caatgggctt 54841 tcagatatgg cccttgcagg tacaattcca attaccgagg acagtgcgcc gggaatgctt 54901 cagagtatta cggcttcaag gatttccaat ctgtttgact tttacggtcc tgcctatacc 54961 attgatgctg catgcgcatc cagtcttgca gcggttatat gcggtattac agggcttttg 55021 agaaaggatt atgacgtatt gattaccggc ggagtggatg tgacactgga tgaaagtccc 55081 ttcgtggtct tttcggcaat aaacgcactt tcgccgaccg gctcctaccc ctttgattcc 55141 cgtgcaaacg gatttgtaat cggtcttggg ggaggggtgc tgattttaaa gaggctggaa 55201 gacgccctga gggacaatga cagaatatat gcgctgatat ccggtttcgg ccagggaagt 55261 gacggaaagg gcaaatatat tgcggctccc aatgaagagg gacaggtacg cgttttaaaa 55321 agcactctgg agatgatggg ctatcctgcg gataccattg aatatataga agcccatggt 55381 acgggaacaa gtgtgggaga cgttgttgag ataaaagcat tgaaaaaggc ctttgacgcc 55441 atgggagtta cgaagaagaa cttctgcgga ataagctccg tgaaatcgaa tatagggcat 55501 ttaaggtatg cggccggaag tccgggcctt atcaaggctg ccatggccat atacaacaaa 55561 attctgccgc ctacggcaaa cattgagaaa atcaatccga agcttgagat tgaagattca 55621 cctttctaca tattgacgga gaaaaaaccg tggagggaga atccttccca tccgagaaga 55681 gcaaatgtca gtgcttatgg attcggtggc gcagattact gccttgcact ggaagaattc 55741 agacccgaat ttataagaaa aacttatgcc ttttcaaaac cgtatgagga tgccaaaaat 55801 gcagacaatg cacaaaatgc actgtctgtg acgcaggaag ttgtaatgtt ctcaggatct 55861 tcaatagaag aaattaatga ggcgtatgga ttgtttgttg gagaaaacag tgaaaacacg 55921 gattttggac aagctgtgtt ctataacaat tcatcagttt cggcaaagaa agagtaccgt 55981 ctggccatat gcgcatcctc catggatgag cttaaggaaa agtacgggat ttttgagcaa 56041 tttgtaaaag aagggaaaac ggagaatctt caggctctta atgtaaaagg gatatatttt 56101 ggaaaaggag aagcggtggc acccgacaaa gtggcgtgga tgttcccggg acaggcttcc 56161 cagtatccca acatgttgaa ggatatatat gaaagctatc ctcaggttgc ggctctttac 56221 atgcaggctg atgcttactg gaagtcaaaa tacggtgata agatttcctc gtttgttttc 56281 ggagatgatg aggaacacct tcagacagtg cttaaagata cgaagaacac tcatcctgca 56341 atgtttttaa gcaatattgc aatgttcagg ctcctttccg agtcgggtgt gagagctgat 56401 tacatgatag gccacagcct gggtgaagta acggctcttt atgccagcgg tatgctggac 56461 ttgaaatcag cccttcgttt gataggtgaa agagggtttg cctttgacgg tattcccaaa 56521 gaggaccgcg gcatgatgat gagcataaag gcggacaagc ccaaagtgga agagttgata 56581 aaagaaagcg gccttaaggt gtatgttgca aaccttaatt cacctgagca gaccgtcata 56641 ggcggaagag aagagcagat agagcggatg gcgcaaatac tggagcaaaa caagattaca 56701 tacacaaaac tgaatgtttc ccatgccttc catacggagc tggttgcaaa tgccgcagaa 56761 cgctattatg aaaaaatcaa agatttgtct tttgatgtac cgaaagccca tgtaatggca 56821 tgccacaagg tggatttcta tcctggggac agggaaaata tggctttgct tccttccatg 56881 ctgaaagagc aggttgtttc gtccgttaac tttacggaat cggtgttaaa gctttatgaa 56941 aaaggtgtca gagtttttgt ggaagccgga ccttcttcgg tgcttacaaa ccttgtaaaa 57001 aatattcttc aggggaaaga tgtaaaagtt attgcttcca acaataagag gaagaatgcc 57061 gttgatgcat acaaacaggc tttggcagag cttttcgcat gtggtgtgga tgttacggtc 57121 ctgccgtcac aaaaggctcc gggacattct gaaaatacgg taagggtggc agagaaggcg 57181 gttgaggaat cttccggctt taaggctgag ataaagattc cggttcaggc aaatgccgag 57241 ccttcgaagc cttctgggaa agaaagtctt gtatacagcg gcgtttcggc aggtttgccc 57301 ggcaccttta agaaagcgtt ttccgatgac aattttgatc tgctttttga aggaaagaac 57361 ctgatagaga gacttacgga cgatgaggca ggcagcatat tggatttaaa tattacaaga 57421 ctcttaaaaa ccgaagcgga aacaactttc aagcaactta cgtcgattaa tgaagttata 57481 cagcttgctg gaaaattggg caaaattgac atgcttgctg attatcagat tgatgaaaaa 57541 gcattaaggc aaatgaccat gacggtgtgc gccggagtgg cggcaggata tgaggccctc 57601 aaagatgctg gcattccgtt gataagggag aggataaaga cctccggcgg ttcctatttg 57661 cccggaagac tcgtgcttcc cgaacacatg caggatgaca ccggagtgat atttgccaat 57721 ggtttcttcc cgattgagac ttgggtggat gaagtttcaa aatatattgc cagcaagttt 57781 gcaagaaaaa caagaaatga tttgatagat ttctatgaat cggttatttc aaaagttagt 57841 gattacagtg tgaaaaaata tctgaccgat tggtttaacc tccactattc aagacttatg 57901 tacaatagtg gagaagagga aatatacaaa ttcaatcatg agttcctgta tagtttcagc 57961 ttgcaggcga acaacagact tgcccaattt atcggagcaa tgggacctaa tttgttctta 58021 aatgccgcat gctcttcaac aattaccgcg gtaactgtcg cagaaggcct gattcgggcg 58081 ggacatgcga gaagaatgat tgtaatagga gcggataatg ttacatccaa atcaattctt 58141 ccctggtctg ctgcaagctt tttgagtacg ggtgttctca ctacttcttc cgacctcttt 58201 gaagctgcgg tgccttttga cagaagaaga agcggcatga ttttgggagc aggtgccgtc 58261 gggcttgtca ttgaaaaaga gtcggatgtg gctgaaaggg gcatgaacgg tatttgccgc 58321 attttaggca cccacgcttt taatacggcg ggacatccgg caaggattga cagcaacaga 58381 tttgccgttg agtttgacaa attcatgacc agaatggagc aagagtatgg atttgccaga 58441 aaagacattg caaaaagaac ggtatactat tcccatgaaa cgttctctcc aaggaaaggc 58501 ggatgtgcat gtgccgagaa gacggcgctg gaaagtacat ttggtgacaa tttcagagat 58561 gtaaaagtta tcaatacgaa gggaatgacc ggacacaccc tgggtgcttc aatagaagag 58621 gctgtggctg caaaagcttt gcagtatcag aaaattcctc cggttgtgaa tttcaaagaa 58681 cctgatccgg atcttgaagg attgaatttg tcttccgggg gttcctacag ctttgactat 58741 gtaataagaa tggttgcggg ttatggttcc cagggcaact atcaccttct acaaaaaatt 58801 gcggaaggtg acaggagaat tttggacgag gaagcatatc aaagatggct tgacagaatt 58861 acgggttcaa aaggcgcaaa gcttgcaaag tgtggaagaa ttcttgtggc ggaaggagca 58921 cagaaggaaa ttcaagctcg ggagattgaa gcgccgaccg gtgaagtgcc atttagcagt 58981 ggtactgctg ccgttttgga cagaaaaccg gattatgccg caagtttcgc aaccccggat 59041 tcgactcata tagacaagaa caagattgcg gataacgcaa ttgtggatga gatactggat 59101 atatactctg aaataaccgg atatcctaaa gagatgctgg atcttaacat ggaaattgag 59161 gctgatctgg gtattgatac ggtgaaacag gcgaccatcc tttcgatgat atcggaaaaa 59221 ttcaatattc cacaggagga cagtgtaaag ctctcaaact atcctactat tggtcatgtt 59281 gtgaacatgg ttcagtcaaa gtatgcaaaa gaggacaata taagcaaagg cagcactgta 59341 ccttatgcaa aaagtgatgt tttcccgggt aatataaatg ttgcaggctc cgaggctgga 59401 aatgttcagg aggaagtttt gaaagttatt tcagagatta cgaaatatcc tgtggaaatg 59461 cttgacatga atatggaaat ggaagcggat ttggggattg acactgttaa gcaggccact 59521 atattctcca tcctcggcga aaaatttaac ctgggggata aaaacgcaaa catatcccaa 59581 tacaagacta taggctctat tgtcgacctt gtaagccaaa gcgcagggaa agggttgaaa 59641 gaaactgccg atttaggtgg cgaaacatac agttcaaatg ttgtcaataa tattgtcaat 59701 tttgaaaaac cggctgacca acctcaaagc ggcatacaag caggcaagtt tggaagcaaa 59761 aatgcaaagg gtctgtccgg aaataatgaa aagaacattg aagaagaggt tttggaaata 59821 atctccacaa tcacaaaata tcctgcggaa atgctggaaa aggatatgga aatggaggcg 59881 gacctgggca tagatacggt aaaacaggcc accatattct ctttgctgag tgaaaagttt 59941 gatgttggca aaaatgaaaa gataaatatt tcggagtaca aaaccatagg cagcattatc 60001 gaacttgtaa aaggcagttt caaaaaagaa gaaccttctt tcgaggatgc caaaggtgaa 60061 gtggcggctg ttgaaagcat cgatgatgaa gacgttaata ttcaaaagga tctttgcctt 60121 cagataccgg tttttgtgga aaaagaagca aaaggcgaag attttgacct gaaggataaa 60181 aagatttggg ttatgggtga caatgacgga caggtaagga aggtggcaca atatttcgca 60241 gaactttcgg ccggtgttga agaattcgtg tttgaataca agggggacgc agcaaagctc 60301 gaaaaggatg tggccgagtt tataaacaaa aaccataaag ctgatgcaat tgtggattgc 60361 actcacctga gaactgatgt tgactttgaa aagcttaccg aagaagaaca ggagaaaatg 60421 ctgtttttaa gcagtgaagc aagattcata ttctataaaa cgctggcaca aaaagtaagc 60481 atgcctgaaa taagaattgt gtgtgcaata tcaatggacg gctgccatgg ttattcccca 60541 aaagaacaga ttgttgcaga cccgttctac agcgctttgt ccggtcttta caaaggactt 60601 ggaaaagagt ggggcaagtc cacggtcagg attgtggatt tagggccaga caagggtagg 60661 atattggaaa atgaggattt atcgatactt gcgaaggaac ttaagaataa atgcgatgat 60721 tatgaaattg gataccatga cggaaaaagg ggtgtaataa agcttaaaaa tctcgaccgc 60781 ggaagtttta aacagatgaa cataccggaa aatgctcatt ttgttattac cggcggcgga 60841 agcggaatta cttcggaaat cacaaaaggg ctgtcccgaa aatttaaagg aaagtacact 60901 ataataggaa ggactgagct tccggatgat tccgaattaa ttcccgatga tgaaacttcg 60961 gcaaacgata taaagcttga gattcaaaag agactggaga gaaccaacaa aaaggtaact 61021 ccggtaatgg tgcaaaagga atatgacaag ctaatcaagt ccaattcaat taaaaagctt 61081 ttagagagta taaaagaaga tggaaacagt gcaacatatt tggcttgcga tgtcagaaat 61141 tatgaggaac ttaaaaaggc tttggataaa gctgtgcagg aaaacgggcc cgtccatgtt 61201 cttatccatg gcgccggagt ggaaagaagc aggcttttga gccagaaaga aagagaagag 61261 tttaatgatg tgttttccgt aaaggcgaaa ggactttgca acctctacag aatattggac 61321 aaaaaagcac tgaagattgc gatggctttc tcctccatat ccggaagatt cggcaatgga 61381 gctcaaattg actactgtgc cgccaacagc ttcttaagcg gctttatggc aatgcttgcg 61441 acaaagtaca aagatatata ttctcttagc ctggcatggt ccggatggaa agatttgggt 61501 atggcctgga gaaatgagtt tgtaaaaaca aactctgagg aaatgggtct tcaccttatt 61561 gaacctgaaa ggggaaccaa tgagtttatc aatatcctga ccggaaatat tgattcaaag 61621 gaagttgtta taagcagagg actcggtgtc cttgacgata acatggtggt aggcgaaagc 61681 ctggacgaca agccgatgat tgattggata acaaagaaaa acggcaggat tgaaaaggtg 61741 ttcaaagttg tttcagtaaa aagggatgcc attttcgacc atcacaggct tggaacggtg 61801 cctttggctc cggcggtatc cttcatggaa ctggcggcgg aagctttcag catgatatcg 61861 ggagaaaaga cacagttctg cttcaggaac atgaatatgg acaagccttt gaagcttttc 61921 catgaggagc cgagagaagt tattgccttg ctggaccaaa aggaaggaac ggacggtgtt 61981 gatgtgaagc tgtacactta cctgaactcc agattcggta tttcgaaact tataggttta 62041 aacagtatga atgtcagcgg caaattaggg gaataccgtc accttcttga cttgatgaaa 62101 attgaaagcg aacccatgga acaagacttt actggaaaag cactcaaaga cttgttgaaa 62161 aggaacccaa attccatcaa tttgggaacc ctgttcattg atgccataaa ggaaaaccat 62221 attttcagga gaaaccaaaa cggcgcggta ttttcaatgc ttcttccgga ggaggaactg 62281 atcaatgaaa agtatcatct ggataaattg ctgataaatc cggcttttgc tgattcggtt 62341 ttccagattt gcggggtaca ttcactgtat aacagtgttg atgtatatct gccatggcag 62401 attgaagagt tcggtgtagt gaaggctccg aaggaaagaa tccgctacaa ggcgtattgt 62461 gcattgaaac atgaggatga tgaagtaaaa gtatatgatg ttattatgct cgatgaaaac 62521 aatgaagtat gctattatgc caagagcgta aagatgaggc ttatccactc atgattacga 62581 acatgattgc ggaggggaaa gacactttaa gactggcaaa tctctttttg gaaaggtatg 62641 cggcagaaca cagggttttc tatcatattg tggacatgcg tgaaatagcc cgaaaaataa 62701 aagtgaatga gattgatgtt ctgtcggtgc tgtccgaaag ggagcttgct catttaaaaa 62761 atttgaggaa tccgaaaaac aggctgcaat ggatttcggg aagatatgcg gtgaaatcgg 62821 caattttcaa gtataaagcg aaagaacgga gcataattga ccctcgttgc ctggatgtgc 62881 tcaaaggggc tgattcggcc cctttcattc tccagtattc tgacatgggt gtatcaataa 62941 cccatgcgtt tccgtattgt atcggaatgg tttcggacag ggcggtggga atagacatgg 63001 aaaagatttt tttgcccgag gatgcattga taaagtattt cttttccgaa agagaggaaa 63061 agattctaaa gagttttgga aatactgatg aatattgtgt gcagagtaca attctatgga 63121 caagaaaaga ggctttgtca aaactttttc gtctgggaat gaggatggat tttaaaaagc 63181 tggatacttt ggaggacgag gtggtttttc aggaaacaaa cagggcgcgt ctgttttctt 63241 ttatatgcaa taattactgt atctctctgg cattgccagg ttttaataaa gattaaaatt 63301 attgactaga aataaaaaaa ttgtccataa tattaatgga caaaaaaaca aagaattaca 63361 tcaaaggaag ataaaaatac tttgttaaaa aattaattat tttttatcta aactattgaa 63421 aatgaaaata aaataatata aaatgaatca tagtgcaaga gatacttgcc agaggatgaa 63481 tattttactg cattcatgct ttatggcagc taatagaggc attaaattaa attttaattt 63541 acaataggag gcgatattaa tggcagtaaa aattggtatc aacggttttg gacgtatcgg 63601 tcgtcttgtg ttcagggcca gtctcaacaa cccgaacgtt gaggttgtag gtataaacga 63661 cccatttatt gaccttgaat acatgcaata tatgttaaag tatgatacag tacatggtca 63721 gttcaaaggt gaaatttcac aagacaacgg aaaactcgtt gtaaacggca gaaaaataag 63781 tgtttatggt ttcactgatc ctgctgagat tccgtggagc gaatgcggtg cggaatacat 63841 cgttgaatca acgggtgtat tcacaactac tgaaaaggct tcagctcact tcaagggcgg 63901 tgcaaagaag gtagttatca gtgctccttc ggcagatgct ccgatgtttg ttatgggtgt 63961 aaaccatgat aaatacacaa aggatatgaa cgttgtatct aacgcttcat gtacaacaaa 64021 ctgccttgct cctctggcta aagttataca tgaaaacttc ggaatcgtag aaggcttgat 64081 gactactgta cacgctacaa ctgcaactca aaagactgtt gacggtcctt caaagaaaga 64141 ctggagaggc ggacgtgcag cagcaggcaa catcattcct tcatcaacag gagctgcaaa 64201 ggcagttgga aaggttatcc ctgaattgaa cggtaagttg acaggtatgg ctttcagagt 64261 tccgactctt gacgtatctg ttgttgactt gacttgccgt cttgaaaaac cggctactta 64321 tgatgaaatc aaagccgctg ttaagaaagc ttcagaaaat gaacttaagg gtattttggg 64381 atacactgag gatgcggttg tttcttcaga cttcatcggc gatccccgca cttcaatttt 64441 cgatgctgaa gcaggtattt ctctcaacag caactttgta aaacttgttg cctggtacga 64501 caatgaatgg ggttattcaa acaaagttgt tgatttgata gttcatatgg cttcggttga 64561 tgcaaaataa ttatagcttt aaatacaaaa aaggttcggt taaaaccggg cctttttgaa 64621 tttaaggttc tttgcagaaa gaaaacttca taagaggaaa caagacttta taaaaaaaat 64681 atataaaaaa atagaatttc atcaaaagcg aaactatttt aatataagaa aaaactttgt 64741 taaaaaattg ataaatttta ttttgcccta ttgaaaagta tgataaaaag atggtaaaat 64801 gttaacggtt tgacggaggc attttttgac gttaatacat aaaatgcggt tttagaatca 64861 ataatacaat aatgttcaat atgtttaggg agcgtgaaaa attatggcaa tgatgaacaa 64921 gaaaaccatt gaggatattg acgtaaaagg taaaaaggtt atagtcaggg ttgattttaa 64981 tgtgcctttg gacgaaaaca gaaagattac cgatgacaag agaatagttg gtgcgcttcc 65041 aaccatcaag tatctggttg aacacggtgc aaaaactata ttggtttcac acctgggaag 65101 accaaaagaa ggttttgagg aaaagtacag catggctccg actgccgtaa gattgggaga 65161 acttcttgga aaagaagtaa taatggcgaa agatgttatt ggtcctgatg caaaggcaaa 65221 agcagcggca ttaaaagaag gagaagtttt aatgctcgaa aatgtcagat tccacaagga 65281 agagactaaa aacgatcctg cttttgcaaa agaattggca agcatggctg aaatttatgt 65341 aaatgatgcg ttcggaactg cccacagagc ccacgcttca acggcaggtc ttgccgacta 65401 tctgccggcg gtatgcggat acctcatcca aaaggaaatt gaggttatgg gcaaggctct 65461 gtcaaatcct gaaagaccgt ttgtggcaat attgggcggt gccaaggttt cagacaaaat 65521 aggcgttatt gagaacctta ttgacaaagt tgacactctt ataatcggcg gaggtatggc 65581 atataccttc tttaaagcaa agggatacag cataggaaca tccctgtgtg aagatgataa 65641 agttgagctt gcaaagagcc ttatggataa agcagagaaa aagggagtaa aactcttgct 65701 tcctgtggac aatgttgtag gcaaagagtt cagcaatgat acagaacgca agactgttcc 65761 gtctgaccag attccggacg gatggatggg tatggacatc ggtgaggaaa caatcaagtt 65821 gtattctgag gcaatcaaga atgccaaaac cgtggtatgg aacggtccta tgggcgtatt 65881 tgagttctcc aactttgcca acggtacaag ggaagttgca agagcggttg ccgagtccgg 65941 agcaatttca ataatcggag gcggagattc tgccgcagct atagaacagc ttggttttgc 66001 cgataagatt acccacattt caaccggagg cggcgcgtct ttggagtttc ttgaaggaaa 66061 agtattgccg ggaattgatg tattaatgga taaataagga gagaagaggt catgagtaga 66121 aaagttattg cagccggaaa ctggaaaatg aacaaaacac cgaaggaagc cgttgagttc 66181 gtacaggctt taaaaggaag agtggcagat gccgataccg aagtagtggt aggtgtgccc 66241 tttgtatgtt tgcctggagt tgttgaggcg gcaaaaggat caaatatcaa ggttgccgca 66301 caaaacatgc actgggagga aaaaggtgct tttaccggag aagtatccgg acctatgctg 66361 gccgaacttg gtgttgacta tgttatcata ggtcactccg aaagaagaca atacttcggt 66421 gaaacagatg aaactgttaa taaaaaggta catgcggcat tcaaatatgg cttaaagccg 66481 attatctgcg ttggtgagtc cctcactcaa agagaacagg gggttaccgc cgaactggta 66541 agataccagg ttaagattgc tttgctggga ctttccgccg aacaggtgaa agaggctgta 66601 atagcctatg aacctatctg ggccattggt acaggaaaga ctgctacaaa tgagcaggca 66661 gaagaagttt gcggcataat aagagaatgc ataaaagagc tttacggtca ggatgttgcc 66721 gaagctatca gaattcagta cggcggaagt gttaatgctg ccaatgcggc agaactcttc 66781 aatatgccga acatcgacgg aggccttgtg ggaggcgcaa gcttaaagct tgatgacttt 66841 gagaaaatcg caaagtacaa caagtaatga ggcgacataa aaatttgtat aaaaatttgt 66901 acagtttata taaaacagtc ccgccaaaaa ttaaagggac tgttttattt aactatattc 66961 aaaaacctta aaatgtggta tatataaata agattgaaat caaatttaat ttttaaatac 67021 ataacgatta aattgaaatg gagtgtataa attatgaaag acaaacttgt gatgttgatt 67081 attttggatg gttatggtat taatccgaga aaagagggaa atgccataga ggctgcaaat 67141 aaaccgaata ttgacaggtt tatgagggaa tatcccaata caatagttcg taccagcggt 67201 atggatgtgg gacttcccga cggtcagatg ggcaattccg aagtagggca taccaatatt 67261 ggtgcaggaa gaattgtata tcaggaactt acaaggataa ccaaatccat tcaggacgga 67321 gacttttttg agaagaaaga atttttggat gctgccgaaa actgcagaaa gcacaattca 67381 aagctgcatc tcttcggact tctttctgac ggcggcgtgc acagccacaa tacccacctg 67441 tatggcctct tggagtttgc aaaaaggcag aatttgaaag atgtgtatgt tcattgcttc 67501 tttgacggca gggacgttcc gccggacagt gcaatgggct atgtggaaga gcttgaaaat 67561 aaaatcaggg aaatcggcgt aggtgaaatt gccacagtta tgggaagata ctacgccatg 67621 gaccgtgaca acagatggga gagagtaaaa cttgcctatg atgccatggt tcttggaaga 67681 ggaaatcaag cccaaagtgc aaaagaggcg gttgcagaat cttataaaag acaagagttc 67741 gatgaatttg taaaacccac agttataatg aaaaaacggc tctccggtgg ctactgtcgg 67801 ggaaaacgac tctataatat tctttaactt caggcctgac agagccagag aaattaccag 67861 ggctttcacg gaggtcaatt tttcaggttt tgaaagggaa aaaggatatt ttccggtgtt 67921 ctttgtctgc atgacccagt atgacaaaac ttttgaaaac gttgttgtgg catttaagcc 67981 tgaaagcctt gagaatacct ttggagagta tatcagcaag aaagggctga gacagcttag 68041 aattgccgaa acggaaaaat atgcccatgt aaccttcttc tttaacggag gtgttgaggc 68101 ggtatacgaa ggagaagaca ggatattgat aaattctccg aaagttgcaa catatgattt 68161 gaagcctgaa atgagtgcct acgaggtaac tgacaaggtg cttgagtgca taaataaaaa 68221 ggaatatgat gtaataatat taaattatgc aaatcccgac atggtggggc ataccggagt 68281 gtttgaggcg gcaaaggctg caattgaagc cattgacgaa tgtttgggca aggttgttcc 68341 cgcagtgctt gagcaaaacg gagtggtatt gataaccgcg gatcacggaa attccgagca 68401 gatgatagat tatgaaaccg gaggaccttt cacggcacat acaacaaatc ctgttcctct 68461 cattgtcatt ggccttggag atgtcaagct cagagaagga aggcttgcgg accttgcgcc 68521 gacaatgctt gatattttag gatttgagaa gcctaaggaa atgacagggg aatcgttgat 68581 tgtaaaataa tagggcaata tatttgttaa taaataacaa aacaaattat acccaaaact 68641 tcggcattac tgccgaagtt ttttatttgt gcttttttag ggtgaaatta aaaaattgga 68701 aaaacaaaaa aacaaataaa atagaaaata tttcttgcaa atactttcat attgtagtaa 68761 attattgtag aataaaattg ttatttttta aaaaataaaa ttgttatttt ttaaaaacta 68821 ttgtttttca gataaagaaa ttgtctgata tcgcatcttt tagagttaca ctgaattact 68881 gacttttaga tgggaggaca tatcaacgat gaaaaaggaa ggtcagtatg attaaaggaa 68941 ttgacaacgc aaacagttgc tggaatgatt ttcagcatga caagaaagag ggttggttgt 69001 catggctggg aatatcgaat aaagagtctt ccaaattgtt ctttatcatt gcctcacttc 69061 atataattat tgtaatggtt caggcgtcag gtaaattgcc tgtgggattt cgggcagtaa 69121 caggaatatt tgagatcgga atttcaattt tattatccta tcgctttggc tatattggta 69181 tgtctttgtc tctgattact aatggtttgg cggcgatgcg tctttttgtc atagccagac 69241 agctggatat ggtggtggca agcgaagccg gtcatttaac aggtgatttg agaataataa 69301 cggacagtgc tccggggctt cttctgaatt tatcggcggc aagggttgct gtaatgatag 69361 tgtcaataat tgtagcatac tcctatgaac aggaacgcaa atacataaac agactggagt 69421 ggctggcctg tgttgacgga gttaccggag tgtacaacca tagatacttc cagacaagac 69481 ttggggaaga aattgagaaa gcaaatttaa gaaatggttc tttggccttg gtaatgattg 69541 atgtggataa ttttaaaaaa tataacgaca cccatggtca tatagcagga gacaggcttc 69601 ttacgaagac tgccgaaata tttaaggcaa gtgcaagaca agaggatatt gtctgtagat 69661 acggaggaga tgaatttgtc atattaatgc ccgatgccga ttctaaaagc attatttcca 69721 tgattcaaaa aataagaaaa gaattttcag actttttgga caccgaagag tttagaatac 69781 atagaaatga gatcagcctg tccgttggat attctatata tccggagctt gcacgaaaca 69841 aagacgattt gattatgcaa gccgacagtg ccctttatca ggcgaaaaac atgggaagga 69901 acaacgtgag aatctacagg gatgtttttg aggatataaa gacatttttc aactcaaacg 69961 aacagcagct gctgggaggc ctgagagccc ttttaggtac ggtatcggcg aaagacaagt 70021 ataccctggg acattcggaa cgtgtcatgg aatatgccgt aaggattgga aaggccatgg 70081 ggcttagcag cgaaaggctg cgtcttctta aaatagccgc tctgcttcat gatataggca 70141 aagtggaaat tcccgaatcc gtgttgaaca aaaccgagcc cctgacccct gcagagatga 70201 aaaatctgcg gcggcatccg atgtatagtg ttgatatatt ggaacccttg tccagtattg 70261 acatgctgat tgattccata aaatatcatc atgaaaggta tgacggcaaa ggatacccta 70321 ccgggaagaa gggtaaggaa ataccgcttg aagcccggat tttatctgtg gcggatgcct 70381 ttgacgctat gttgtccgac cgtccctata gaaaaggaat gaaaataaat gaagtactgg 70441 ctgagttgaa aaacaattcc ggtacacagt ttgatcctga aacagtggaa gcctttctca 70501 gcacttttga taattctgac tgtgacagtc atagtattag tcatagcatt gatgaagcaa 70561 tttaaaaaag gttgatttgt tttcccggaa atattaaaat ggaaatgttg aaaaaatgtt 70621 ttaagatggg tcattatgga taaaatatac tatggttttg caataaatgc tttctattaa 70681 ttggactttg tggtaatatg gtagaaggat gcagtgttaa ttttttaaca tataaaaata 70741 agctatatga agggagaatg gagaatgaaa cagtacttgg aaattgagag cgtatttgcg 70801 agagaaatac ttgattcaag gggtaatccc acagtagagg tggaggttat agcagaaggc 70861 ggatttgtag gcagagcggc agttccgtca ggtgcatcca caggagcttt tgaagccgta 70921 gaactgaggg acaacgacaa aaacagatat ttgggcaaag gtgtccagaa agcagtggaa 70981 aacgtaaaca atattattgc gcctgaagtg gaaggcatga atgtgtttga ccaggcggct 71041 gttgacaacc tcatgataag cctggacggt actccaaaca agtcaaagct cggtgccaat 71101 gccatcctgg gagtttccct tgcgacagca aaagctgctg ctgaagctct tgggttaagc 71161 ctttaccaat atatcggagg agtaaatgca aagacccttc cggtacctat gatgaacatc 71221 ataaacggag gaaaacacgc cgacaacagt gtaaatatcc aggagtttat gataatgccg 71281 gtgggtgctt cttccttcag acatgcactt caaatgtgcg cagaagtttt ccataacctg 71341 aagaaagtgt taaaggataa aggttacagt acggctgtgg gagacgaagg aggatttgct 71401 ccgaatctta aaactgatga agaggcaatc caggttatat tggaagctgt tgagaaagcg 71461 ggctacaaac cgggtgatga tttcagactc gcaatagacg ctgcttccac ggaaatgtac 71521 caggaagacg gaacatatct tttctggaaa tccggtgtga aaaagacaaa agaggaaatg 71581 ataaactact gggaagagct tgttaataaa tacccgatta tttctctgga agacggtgtt 71641 gcggaagaag actgggaagg ctggaaaatg cttaccgaaa gactcggaaa aagaattcag 71701 cttgtgggag acgacctctt tgttacaaac acaaccagac ttaaaaaagg tatagaattg 71761 ggagttgcca attccatact tattaaagta aaccaaatag gaactcttac tgaaaccctt 71821 gatgccatag aaatggcaaa ccgtgcggga tataccgcag ttgtatccca cagatcggga 71881 gagactgaag atgcaacaat tgcggacata gctgtggcaa ccaatgccgg acagataaag 71941 accggagctc cctcaagaac tgaccgtgtg gcaaaataca atcagctgtt aagaatagag 72001 gaagaaatag gagcagtcag ccgttatccc ggacttgatg cctggttcaa ccttaaaaag 72061 aaataagatg ccaggactgg aacaatagac aaaaaggccg attttttcac gtgaaagaca 72121 agatacgcga aaaacacttc aggatgaaaa agtttgaaaa aatattggca ttgatgcttg 72181 tattctgcgt attagtatgt tacaatgtat cttgtcaatt tcttaggagg tgccttttag 72241 aatgcaaata gcagttacta ttttacattt gattttctca atatcgctga ttgtcattgt 72301 gttgctccag tcaggcagac gtgcaggatt gtcgggttct attgccggcg gtgctgagac 72361 tttttttgga aagaacaaag gaaggactat tgatgctatt ttaggtaaat atacagcagt 72421 tgcggccata ggatttttga ttacttcagt tgtgctgcag cttattataa attccaaata 72481 agacaattga aaaaggaaac tgtattattt gcagtttcct tttttgcttt ttgtagcttt 72541 tctatgcctt tctttttgtt taatatatat ttcgagataa tttatgctta atactctatt 72601 ttattccttg taattattat tctaatttag taatataata ttggacttta aatttgtctg 72661 catactttta taacaactgc ggttattttt ttggttgttg gttgggtttt tattataatt 72721 gccttaagct attcaataat aaatttggag gtattggttt cgatggaaag agaacaggca 72781 ctggaagagt tgaaggccag aattgaaaat gaaaacttga taaaacattc tcttgcagtt 72841 gaagcaataa tgaaggattt ggctttttat ttcaaagaag atatagataa atggggtctg 72901 gcaggattgc tccatgacat tgactgcgaa aaaacggcgg gcgatatttc aaagcacagc 72961 ctggtggggg ctgagatttt agagtccctt gatattgaaa gttcaattat atatgccgta 73021 aaagcccaca atgattatca tggtattgaa agaaaaagaa agattgacaa ggctttatac 73081 tgtgccgatc ctgctgcagg gcttataact gccgcagctt tgattcttcc ttcaaaaaaa 73141 ttggaagatg ttactgttga ttttcttata agaagaatga acgaaaagag ttttgccaaa 73201 ggtgtaaaca gagagcagat aaagtcatgt gaacagttag gcctttcttt ggagaaattt 73261 ctcgaaatcg ctttggaagc aatgaaaaag atttcagatg aattaggtct ttaacagttt 73321 tttaaagaag cccataactt caataccata aaaaaccagg gtttaacaat cttggtt //