LOCUS NZ_ACVX01000022 64041 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00046, whole genome shotgun sequence. ACCESSION NZ_ACVX01000022 NZ_ACVX00000000 VERSION NZ_ACVX01000022.1 GI:256005007 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 64041) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 64041) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000022. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..64041 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene complement(<1..1893) /locus_tag="ClothDRAFT_1840" CDS complement(<1..1893) /locus_tag="ClothDRAFT_1840" /inference="protein motif:TFAM:TIGR01643" /note="TIGRFAM: YD repeat protein; PFAM: YD repeat-containing protein; KEGG: gur:Gura_1472 YD repeat-containing protein" /codon_start=1 /transl_table=11 /product="YD repeat protein" /protein_id="ZP_05429979.1" /db_xref="GI:256005008" /db_xref="InterPro:IPR006530" /translation="MQIKITPEEMTRVAERIRQLSDKFDDMAQDIKRIISSIDWELRS REGVDQKASLARAAAINIATGLKEMSQDLIEARDQMIEADNKASAAARKMKTADFISR IASAILTGNGIASAIVAGYSLWNRLIGPGTANCPNTFAGDPVNVVSGNFYLKRRDITI PSRGMALEITRYYNSMDNTEGIFGKGWKIDYETCLKKKEDSEDIIVAYPDGNIRVFEY TDTGSFKSPKGVYDTLLKTEDGTYILKVQKGITYKYDQAGNLISISDSNSNEIQFKYN REGLLSSVMSPGGKLLMFSYEGGRIVSITDHTGRNLKYKYDEKGNLTQVVYPDGGKIT YAYDNIGLISITDQNGNTYVQNTYDEKGRVVRQLDHENNELIIEYDEENRENTFKWIK SGITRVYKYNTDMLLTEIRYDDGSVQKYTYDENLNRNSETDRNGNTTYKKYDDKGNLI EVISPEPFCYKTKYSYNEEGRLIKVVSPGGGEVSFEYDERGNLLKRIVKTGSRSYSEW AYTYDQYGRMTTSKDAENNTKTFEYGEEDVNKPTLIKDAVGNIFKYEFDKVGRVVATT TDYGTVRMKYNECDRITHITDTEGNTTRICYDKAGNMTKVIAPKQYAEKGENGAGYAF EYNAMDK" misc_feature complement(1642..1890) /locus_tag="ClothDRAFT_1840" /note="Proteins of 100 residues with WXG; Region: WXG100; cl02005" /db_xref="CDD:154701" misc_feature complement(<109..1140) /locus_tag="ClothDRAFT_1840" /note="Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209" /db_xref="CDD:33022" misc_feature complement(898..999) /locus_tag="ClothDRAFT_1840" /note="RHS Repeat; Region: RHS_repeat; cl11982" /db_xref="CDD:159659" misc_feature complement(838..948) /locus_tag="ClothDRAFT_1840" /note="RHS Repeat; Region: RHS_repeat; cl11982" /db_xref="CDD:159659" misc_feature complement(385..498) /locus_tag="ClothDRAFT_1840" /note="RHS Repeat; Region: RHS_repeat; cl11982" /db_xref="CDD:159659" gene complement(2036..2824) /locus_tag="ClothDRAFT_1841" CDS complement(2036..2824) /locus_tag="ClothDRAFT_1841" /inference="protein motif:PFAM:PF07833" /note="PFAM: copper amine oxidase domain protein; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="copper amine oxidase domain protein" /protein_id="ZP_05429980.1" /db_xref="GI:256005009" /db_xref="InterPro:IPR012854" /translation="MLTVFALTILFSNITFAINIPLRVLVNGEELYFPDEKPFIDANG RTQTPARFIGEALGATVTWDANAKKAVFKMDGTTLELFIGEREYQLNGQKKQMDTEAL LINGRTFVPARYVAEAFGATVRWKDEIKTVYIDANKTDKVEDEDDTREVAGFIVPKDT DLMVAASKDDTSYEVVFTIGFLKKDVEKQKDDMEKILLQKFSEETVKEIMSVVRSKVK DTDVIEARYFYDKKADQYMYMPKSWPIRGSTITLYIYRKGDKPF" misc_feature complement(2423..2698) /locus_tag="ClothDRAFT_1841" /note="Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833" /db_xref="CDD:149091" gene complement(3109..4458) /locus_tag="ClothDRAFT_1842" CDS complement(3109..4458) /locus_tag="ClothDRAFT_1842" /EC_number="2.7.2.4" /inference="protein motif:TFAM:TIGR00657" /note="KEGG: tau:Tola_0621 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein" /codon_start=1 /transl_table=11 /product="aspartate kinase" /protein_id="ZP_05429981.1" /db_xref="GI:256005010" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /translation="MKVAKFGGSSLADANQIRKVCDIILSDKDRKLIVVSAPGKRCKE DTKVTDLLIALGEKYYKEGKADAELQAVIDRFDDIVKGLELSPDITQMVADDLKKRLE CNNGNKDKFMDTIKAAGEDNNAKVVAAYLVSRGIDAEYVNPKDAGLLLSEEYGNARVL PESYENLKRLRERDKIMIFPGFFGYSKKGDVVTFPRGGSDITGAILAAAVKADVYENF TDVDSVFAANPNIIENPKPIATFTYREMRELSYSGFSVLHEETLEPVYRMEIPVCIKN TNNPSAPGTTIVPKRKLDNGPVIGIASGTGFCCIYISKYMMNREIGFGRKVLSILEDE GLSYEHIPSGIDNMSIIIEQKQLDKAKEERVVRRIKDELNVDDIKIEYDRALVMIVGE GMMSTVGIAARACTALAKANVNIEMINQGSSEVSMMFGVKAEDNVKAVKALYDEFFS" misc_feature complement(3112..4458) /locus_tag="ClothDRAFT_1842" /note="aspartate kinase; Reviewed; Region: PRK09034" /db_xref="CDD:181617" misc_feature complement(3595..4458) /locus_tag="ClothDRAFT_1842" /note="AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245" /db_xref="CDD:58611" misc_feature complement(order(3685..3687,3724..3726,3859..3861, 4099..4101,4312..4314,4444..4446)) /locus_tag="ClothDRAFT_1842" /note="putative catalytic residues; other site" /db_xref="CDD:58611" misc_feature complement(order(3784..3789,3796..3801,4432..4440, 4444..4446)) /locus_tag="ClothDRAFT_1842" /note="putative nucleotide binding site; other site" /db_xref="CDD:58611" misc_feature complement(order(4099..4101,4312..4314,4348..4353)) /locus_tag="ClothDRAFT_1842" /note="putative aspartate binding site; other site" /db_xref="CDD:58611" misc_feature complement(3313..3540) /locus_tag="ClothDRAFT_1842" /note="ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911" /db_xref="CDD:153183" misc_feature complement(3427..3429) /locus_tag="ClothDRAFT_1842" /note="allosteric regulatory residue; other site" /db_xref="CDD:153183" misc_feature complement(3115..3306) /locus_tag="ClothDRAFT_1842" /note="ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916" /db_xref="CDD:153188" gene complement(4589..5836) /locus_tag="ClothDRAFT_1843" CDS complement(4589..5836) /locus_tag="ClothDRAFT_1843" /EC_number="1.1.1.3" /inference="protein motif:PRIAM:1.1.1.3" /note="PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: gur:Gura_2178 homoserine dehydrogenase" /codon_start=1 /transl_table=11 /product="Homoserine dehydrogenase" /protein_id="ZP_05429982.1" /db_xref="GI:256005011" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR005106" /translation="MVNIAVMGYGVVGSGVVEVIRKNSVSISKKAGQEIRVKKILDIR DFPDSPERDLFTKNPDEIFDDPSIGIVVETIGGIGAAYEFTKKALSKGKNVVTSNKEL VATHGPELLKLAKENGVNYLFEASVGGGIPIIRPLNRCLAANEIHSIIGILNGTTNYI LTQMKRQGKDFDEALKEAQQKGYAEADPTADIEGHDACRKIAILSSIAYNEFVDYKKI HTEGIKKISLADMKYAESMDSTIKLVAISEKIGDGIMARVAPAIVSSKSPLYSVEDVF NAIVVRGDAIGEVMFYGPGAGKLPTASAVVADVIEIVKHWGTCGSYNWVVKDGGNVID LKETRTRYFVRLKVENEAEAKKAVENAFGNVEWVKAYDASVQDELAFVTSCVLEKDYC NSLQQLKGSKAVKDVVNAIRVLD" misc_feature complement(4595..5836) /locus_tag="ClothDRAFT_1843" /note="homoserine dehydrogenase; Provisional; Region: PRK06349" /db_xref="CDD:180538" misc_feature complement(5465..>5599) /locus_tag="ClothDRAFT_1843" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature complement(4907..5443) /locus_tag="ClothDRAFT_1843" /note="Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742" /db_xref="CDD:144371" gene complement(5847..6065) /locus_tag="ClothDRAFT_1844" CDS complement(5847..6065) /locus_tag="ClothDRAFT_1844" /inference="similar to AA sequence:KEGG:Psyc_1461" /note="KEGG: par:Psyc_1461 aspartate kinase" /codon_start=1 /transl_table=11 /product="aspartate kinase" /protein_id="ZP_05429983.1" /db_xref="GI:256005012" /translation="MEDYAGILSSIINRIADSKANIITINQNIPINGLADVTITIETG QMTRDIKDLLDDISSIEGVKRQEILARE" misc_feature complement(5856..6065) /locus_tag="ClothDRAFT_1844" /note="ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141" /db_xref="CDD:186839" gene complement(6029..6289) /locus_tag="ClothDRAFT_1845" CDS complement(6029..6289) /locus_tag="ClothDRAFT_1845" /inference="protein motif:COG:COG4492" /codon_start=1 /transl_table=11 /product="ACT domain-containing protein-like protein" /protein_id="ZP_05429984.1" /db_xref="GI:256005013" /translation="MRNTSKYYLVDASVLPKVFIKVVEAKRILASGAIKNVNEAVRKV GISRSAYYKYKDHIFPFYETSQGKVITLFLLWKIMPGFCRAL" misc_feature complement(<6047..6289) /locus_tag="ClothDRAFT_1845" /note="hypothetical protein; Provisional; Region: PRK04435" /db_xref="CDD:179848" gene complement(6466..7986) /locus_tag="ClothDRAFT_1846" CDS complement(6466..7986) /locus_tag="ClothDRAFT_1846" /inference="protein motif:PFAM:PF01966" /note="PFAM: metal-dependent phosphohydrolase HD sub domain; response regulator receiver; SMART: metal-dependent phosphohydrolase HD region; response regulator receiver; KEGG: scl:sce2546 putative regulatory protein" /codon_start=1 /transl_table=11 /product="response regulator receiver modulated metal dependent phosphohydrolase" /protein_id="ZP_05429985.1" /db_xref="GI:256005014" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /translation="MRKNRQGKSSDIKIIVVDDEKGILDSLSVIIKRLGYQYTGVNNP LEAIERVREEEFDLMILDFLMQPILGDKVVEEIRKFNKDIYILLLTGYKDAAPPLKAI KSLDIQGYCEKADNFDQLILLIESAVKSIYQKRTIRNFRDGLNKILLTVPDIYRLKSI EELLEEILRHIMAFVNCKDAFIIIDNLIGDDKNESLFKGMGIYDVSPDKFIDMLEPAF LEEMGRTRTLKQIAYVEKGIILPLMSDTIQTLGVIYLETTHIPVEMELLKIYITQAAT SISNIYLHSIVSIKNDELDRTYNELKQRYLDAIQVLRLTVDAKDVYTRGHSDRVAYYA VKIGKSFNLDEESLEKLKTAGIFHDIGKIGIADDILFKTDKLTESEYEEIKKHPIKGA HILSAVSMFKDIVPLVKYHHERIDGRGYPFGLKGDEIPFLARIISVADAFDAMTSDRQ YRSKLCLEEAKNQMITNSGTQFDAEVVKRFLVLLEDYDTMQKEIEYTFKTKESCIW" misc_feature complement(7603..7944) /locus_tag="ClothDRAFT_1846" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature complement(order(7645..7650,7657..7659,7717..7719, 7777..7779,7801..7803,7930..7935)) /locus_tag="ClothDRAFT_1846" /note="active site" /db_xref="CDD:29071" misc_feature complement(7801..7803) /locus_tag="ClothDRAFT_1846" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature complement(order(7777..7785,7789..7794)) /locus_tag="ClothDRAFT_1846" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature complement(7642..7650) /locus_tag="ClothDRAFT_1846" /note="dimerization interface; other site" /db_xref="CDD:29071" misc_feature complement(6625..7011) /locus_tag="ClothDRAFT_1846" /note="Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077" /db_xref="CDD:28958" misc_feature complement(order(6667..6669,6910..6915,7009..7011)) /locus_tag="ClothDRAFT_1846" /note="Zn2+ binding site; other site" /db_xref="CDD:28958" misc_feature complement(6910..6912) /locus_tag="ClothDRAFT_1846" /note="Mg2+ binding site; other site" /db_xref="CDD:28958" gene 8289..9377 /locus_tag="ClothDRAFT_1847" CDS 8289..9377 /locus_tag="ClothDRAFT_1847" /inference="protein motif:PFAM:PF01408" /note="PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: AGR403Wp" /codon_start=1 /transl_table=11 /product="oxidoreductase domain protein" /protein_id="ZP_05429986.1" /db_xref="GI:256005015" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /translation="MKKIRLAVIGTGMAWERLHYPAIKELEDKYEIVALCNRTRKDAE EFAKKINLSMDRVYDDYNEMLKRQDIDAVDILVPIESNYTVSEAVAKAGKDFICEKPL AANREEAKKYLELSKKYNVRIMIAENYRYSDEYNKIRDIVNSGKIGDVVYFIKNNISC FPCEMTKDTFAATEWRQHPKFYGGAFLDAAVHDIAAMRHIFGAVECVQAFGKPQAEDF NPYVSVNAHILFKNGVIGYYTYYTSGIETQKPAVGFRIFGTKGEIYLEDKTCGIINVS YHDGTSELVNFIPERGFYNELLNYYNAINGTEQISVTPEMEYGDVKMVFDILDSVSFR EIIYVDEEEPKRRLEIADDEAKIHPFLQ" misc_feature 8289..9311 /locus_tag="ClothDRAFT_1847" /note="Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673" /db_xref="CDD:31017" misc_feature 8298..8666 /locus_tag="ClothDRAFT_1847" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature 8703..8993 /locus_tag="ClothDRAFT_1847" /note="Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611" /db_xref="CDD:159579" gene complement(9448..9822) /locus_tag="ClothDRAFT_1848" CDS complement(9448..9822) /locus_tag="ClothDRAFT_1848" /inference="protein motif:PFAM:PF00072" /note="PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: gsu:GSU3198 chemotaxis protein CheY" /codon_start=1 /transl_table=11 /product="response regulator receiver protein" /protein_id="ZP_05429987.1" /db_xref="GI:256005016" /db_xref="InterPro:IPR001789" /translation="MDKTKILVVDDALFMRKLLGNTLKDIGYSNIVFAQDGYEAVDKA REIQPEVVTLDVSMPGMDGLEAIKKILQVSCDSKIIMVSAVTSEKVIQQAMKNGAVAY IPKPFSRKDVENGLRQCNAYIE" misc_feature complement(9466..9804) /locus_tag="ClothDRAFT_1848" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature complement(order(9505..9510,9517..9519,9574..9576, 9634..9636,9658..9660,9790..9795)) /locus_tag="ClothDRAFT_1848" /note="active site" /db_xref="CDD:29071" misc_feature complement(9658..9660) /locus_tag="ClothDRAFT_1848" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature complement(order(9634..9642,9646..9651)) /locus_tag="ClothDRAFT_1848" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature complement(9502..9510) /locus_tag="ClothDRAFT_1848" /note="dimerization interface; other site" /db_xref="CDD:29071" gene complement(10066..11751) /locus_tag="ClothDRAFT_1849" CDS complement(10066..11751) /locus_tag="ClothDRAFT_1849" /EC_number="4.2.3.1" /inference="protein motif:TFAM:TIGR00260" /note="KEGG: abu:Abu_2067 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="ZP_05429988.1" /db_xref="GI:256005017" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /translation="MIGEQSVELNFCALCPVVCKNVVDLIVICIVLPNVREFVTTMIE LHFAIWNICDLRYMGGNEMYYESTRGGLKSVSSAEAIKRGIAPDGGLFVPENKVSFTG SEISAMADMSYQERALYILKHYLTDYSDEEIADCVYNAYTDEKFDDKRIAPLVQLNEN VNILELWHGPTCAFKDMALQILPHFLVKAVRKTGETGEIVILVATSGDTGKAALEGFK DVEGTRIIVFYPQDGVSQVQKMQMVTQEGKNVYTIGVEGNFDDAQSGVKAIFTDEELK QKMDKGNFKFSSANSINWGRLVPQIVYYFSAYADMLKNGEIKEGDKINFVVPTGNFGN ILAAFYAMQMGLPVNRLICASNDNNVLTDFINTGVYDKNREFKRTISPSMDILISSNL ERLLFELTGHDPLPVNNWMSSLKETGKYTVDNTMKKKISEIFWGGYSNEAETLKTIEA IYKEYGYVIDTHTAVGVDVYDKYVISTGDVTKTVIASTASPFKFNESVVKAVLGNEAL KGRTEFELLEVLAKECRLKIPEGLKDLDKKPVLHKQVCSKFDMKQQVESILGL" misc_feature complement(10213..11565) /locus_tag="ClothDRAFT_1849" /note="Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498" /db_xref="CDD:30844" misc_feature complement(10090..11559) /locus_tag="ClothDRAFT_1849" /note="Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560" /db_xref="CDD:107203" misc_feature complement(order(10288..10290,10759..10764,11227..11229)) /locus_tag="ClothDRAFT_1849" /note="pyridoxal 5'-phosphate binding site; other site" /db_xref="CDD:107203" misc_feature complement(11227..11229) /locus_tag="ClothDRAFT_1849" /note="catalytic residue; other site" /db_xref="CDD:107203" gene complement(11817..12974) /locus_tag="ClothDRAFT_1850" CDS complement(11817..12974) /locus_tag="ClothDRAFT_1850" /inference="protein motif:PFAM:PF01734" /note="PFAM: Patatin; KEGG: spl:Spea_0423 patatin" /codon_start=1 /transl_table=11 /product="Patatin" /protein_id="ZP_05429989.1" /db_xref="GI:256005018" /db_xref="InterPro:IPR002641" /translation="MDRDIKLANLVLGGGGVLGIAYIGMLEVAEERGFYFKNIAGVSA GALVGAFIGAGYNSCELKRILDEFDFNKMKLSDISREIPVVKKYMEYSLSSAFRGNKS FKDFLNMPVMDRGKHYSSENNGEFVEVDEEFTGYRRNLLKNIVTYSKEGCLFDGDYLE EWVYKTLKRKGIKTFADLRGGRTDRTNPNGYKVRMTAVDANRGRIVVLPDDISYYGID PDRLEVAKAVRMSTSVPFAFKPVEVLKKDGGSVKKHYLVDGGVLDNLPVWLIQPSMAI PLIVCELKGRDKLFSIMTPLNILKGLVSAVHDFGIPNIKHYKNSYLVRIYTGDISFLD FELSEKDKKFLIDSGRIAALCTLRKVYRRKYIQRYAAFYILRRILGLYNCL" misc_feature complement(12168..12917) /locus_tag="ClothDRAFT_1850" /note="ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207" /db_xref="CDD:132846" misc_feature complement(12840..12854) /locus_tag="ClothDRAFT_1850" /note="nucleophile elbow; other site" /db_xref="CDD:132846" misc_feature complement(11913..>12404) /locus_tag="ClothDRAFT_1850" /note="Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396" /db_xref="CDD:176430" gene complement(13063..14220) /locus_tag="ClothDRAFT_1851" CDS complement(13063..14220) /locus_tag="ClothDRAFT_1851" /inference="protein motif:PFAM:PF07719" /note="PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: TPR Domain containing protein" /codon_start=1 /transl_table=11 /product="Tetratricopeptide TPR_2 repeat protein" /protein_id="ZP_05429990.1" /db_xref="GI:256005019" /db_xref="InterPro:IPR001440" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /translation="MIDFKNELQNYPMIDLDKLSQANPNIPDNIKNSIVLYNKALEDF RAKSEDIAIIELKKAISLNPDFHEAMNLLGIFYMYIGENDKAAEVFQKVVDAEKNSVM AMRYLKEIDSGYDPVGNKQEKDKKSRKKKERNRGAAQLSNQVTVKSSASFSFKKLIKI WEYKPMDTARLFLGFVIGALLVFLLSYNYYFREENNEQLEQLTEENNTLIGEKNEIQK KYDELNEKYQGLNDTFEEVKKQVDYYLNASKLLQIEKYASQNQYREAADLLLLLKNTA FTGVEKEKFDKLSQDVMPKAAQEEYNKGRELYNRKNYQEAVERFERSRSYSDNWRYAV NNLYYLGVCYQELNNTTKALEIFEEVVNKYPNTSYAGYSRERINYIRGSQQ" misc_feature complement(<13900..14118) /locus_tag="ClothDRAFT_1851" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature complement(order(13903..13908,13984..13989,13996..14001, 14005..14010,14095..14100,14107..14112,14116..14118)) /locus_tag="ClothDRAFT_1851" /note="binding surface" /db_xref="CDD:29151" misc_feature complement(order(13942..13944,13951..13953,13963..13965, 13999..14001,14044..14046,14053..14055,14065..14067, 14101..14103)) /locus_tag="ClothDRAFT_1851" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature complement(13078..>13341) /locus_tag="ClothDRAFT_1851" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729" /db_xref="CDD:31915" gene complement(14332..15618) /locus_tag="ClothDRAFT_1852" CDS complement(14332..15618) /locus_tag="ClothDRAFT_1852" /EC_number="6.3.2.17" /inference="protein motif:TFAM:TIGR01499" /note="KEGG: sfu:Sfum_1671 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein" /codon_start=1 /transl_table=11 /product="FolC bifunctional protein" /protein_id="ZP_05429991.1" /db_xref="GI:256005020" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /translation="MNYEQALEYIHGTHKFGIKLGLDNIRKLLEFMDNPHRKLKYVHV AGTNGKGSTVAFISSILKESGYKVGIYTSPYIERFTERIKINNDEISKEDLARITEYV KGKVELMISQGENHPTEFEIVTAIAFQYFYEKDCDIVVLEVGLGGRFDSTNVIDSPLA AVITTISYDHMAQLGDTLDKIAFEKAGIIKRGTDVVLYPQTREADKVFEEVCHEKGAR LHKLSFHSINIKKFSPDGQEFDYGEFKSLKIGLLGEHQVKNAVVALETALILARKGYD RICESSVRKGLADAKWPGRLEILKKEPIFLIDGAHNAEGAKTLSEFLKTYFPGKKIVF IIGVLKDKDFKSMIEVCAPLAEDIITVTPNSDRALPAETLAQNLENYCKNVSISDTIV NAVEKSLKIAPKDGVICAFGSLYYIGEIRSVLMNHK" misc_feature complement(14335..15618) /locus_tag="ClothDRAFT_1852" /note="Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285" /db_xref="CDD:30633" misc_feature complement(14818..15489) /locus_tag="ClothDRAFT_1852" /note="Mur ligase middle domain; Region: Mur_ligase_M; pfam08245" /db_xref="CDD:149357" misc_feature complement(14515..14745) /locus_tag="ClothDRAFT_1852" /note="Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875" /db_xref="CDD:145824" gene complement(15714..18446) /locus_tag="ClothDRAFT_1853" CDS complement(15714..18446) /locus_tag="ClothDRAFT_1853" /inference="protein motif:TFAM:TIGR00963" /note="TIGRFAM: preprotein translocase, SecA subunit; PFAM: SecA DEAD domain protein; SecA Wing and Scaffold; SecA preprotein cross-linking region; SEC-C motif domain protein; KEGG: gme:Gmet_0951 preprotein translocase subunit SecA" /codon_start=1 /transl_table=11 /product="preprotein translocase, SecA subunit" /protein_id="ZP_05429992.1" /db_xref="GI:256005021" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR014021" /translation="MLKVFEKIFGSYSDREVKRIKPIIDRIEALEPEMQALSDEQLKA KTPEFKRRLSQGETLDDLLPEAFAVVREASRRVLGMRHFRVQLIGGVVLHQGRIAEMK TGEGKTLVATLPVYLNALEGKGVHVVTVNDYLATRDSEWMGKLYNFLGLSVGLIVHGL TNEERKKAYSCDITYGTNNEFGFDYLRDNMVIYKEDMVQRDLHFAIVDEVDSILIDEA RTPLIISGVGDKSTDLYTRADAFVRRLKVKVFTELDDKEQTDDIEADYIVDEKANTAT LTASGVKKAEEFFGIQNLSDPDNMTISHHINQALRAHGLMKRDRDYVVKDDQVIIVDE FTGRLMYGRRYSNGLHQAIEAKEGVKVERESKTLASITFQNYFRMYRKLSGMTGTAQT EEQEFRSIYNLDVVVIPTNMPVIRVDHPDSVYKNERGKFNAVINQVIECHKKGQPVLI GTISIEKSELLSSMLKRHGIPHQVLNAKYHEKEAEIIAQAGKLGAVTIATNMAGRGTD ILLGGNPEFMAKQEMRKRGFREDVINQATGFNDTNDPEILEARKVYRELYEGFKKITD AEREKVVAAGGLFIIGTERHESRRIDNQLRGRAGRQGDPGESRFYISLEDDLMRLFGS DRLMGMVEALGLEEDQPIEHKMLSNAIENAQKRVESRNFAIRKSVLEYDDVMNKQREV IYAQRRKVLNGENLKENIVKMMENIADYIVNLFCSENPHPDFWDWEGIRSYTEKAYVP EGTLDFSKEQMEDLNKEKLRQIILDSMLKRYEEKEKEFGSELMRELERVVLLRVVDQK WMDHIDDMDQLQHGVRLRAYGHKDPVIEYKFESFEMFEEMNRNIQSDVVRIILNTHID RNRMPQRQKVAEPVTASHGEEVRKPVVKRNKVGRNELCPCGSGKKYKKCCGIDE" misc_feature complement(16413..18404) /locus_tag="ClothDRAFT_1853" /note="preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898" /db_xref="CDD:183820" misc_feature complement(<17805..18173) /locus_tag="ClothDRAFT_1853" /note="DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029" /db_xref="CDD:175389" misc_feature complement(17385..17762) /locus_tag="ClothDRAFT_1853" /note="SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043" /db_xref="CDD:144583" misc_feature complement(<16896..>17180) /locus_tag="ClothDRAFT_1853" /note="Sodium:solute symporter family; Region: SSF; cl00456" /db_xref="CDD:186007" misc_feature complement(15891..16526) /locus_tag="ClothDRAFT_1853" /note="SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516" /db_xref="CDD:148879" gene complement(18466..19065) /locus_tag="ClothDRAFT_1854" CDS complement(18466..19065) /locus_tag="ClothDRAFT_1854" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429993.1" /db_xref="GI:256005022" /translation="MLYLTVMLIAFVLALAVQGMKGKPCDFSGIRLRKMWLAIVAFVL QTVTRILGIRGVESAVKFSFLIQAVVFVLLLFCFWFNREYIGLWFVGLGASLNALVML VNGGRMPVSLEAMQKAGIKEVTEMIMSGADNKHAVISSTTKLKFLADIIHLPGFIGQG MGVVSIGDLVVALGLFVFVFELFTHPMTALKALKKENVK" sig_peptide complement(19006..19065) /locus_tag="ClothDRAFT_1854" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.852) with cleavage site probability 0.551 at residue 20" gene complement(19147..19542) /locus_tag="ClothDRAFT_1855" CDS complement(19147..19542) /locus_tag="ClothDRAFT_1855" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05429994.1" /db_xref="GI:256005023" /translation="MFRRLFISLLILSTLTSDGTVNIAGYLIDLYRYDGLEPDLVVLD GNLFKEAVCENAEDSELLSADAYCIICAEKSKDDDKRSCGFKLFNNKYNYNAFLYKFP VQWIGENGSLFYASRDISLYMSDLSPPCI" sig_peptide complement(19483..19542) /locus_tag="ClothDRAFT_1855" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.891) with cleavage site probability 0.639 at residue 20" gene complement(19634..19945) /locus_tag="ClothDRAFT_1856" CDS complement(19634..19945) /locus_tag="ClothDRAFT_1856" /inference="protein motif:TFAM:TIGR02531" /note="TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor; KEGG: lpp:lpp1203 hypothetical protein" /codon_start=1 /transl_table=11 /product="TrpR like protein, YerC/YecD" /protein_id="ZP_05429995.1" /db_xref="GI:256005024" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR013368" /translation="MGVETVMNSKIRDELTDKLFEAILLLDNIEECYDFFEDICTISE IKAMAQRLEVARMLREGKTYTEISERTGASTATISRINRALNYGADGYKKILDRMYNK K" misc_feature complement(19649..19912) /locus_tag="ClothDRAFT_1856" /note="Trp repressor protein; Region: Trp_repressor; cl01121" /db_xref="CDD:186345" gene 20826..22181 /locus_tag="ClothDRAFT_1857" CDS 20826..22181 /locus_tag="ClothDRAFT_1857" /EC_number="2.7.7.21" /inference="protein motif:TFAM:TIGR00277" /note="KEGG: scl:sce1090 hypothetical protein; TIGRFAM: metal dependent phophohydrolase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain" /codon_start=1 /transl_table=11 /product="polynucleotide adenylyltransferase/metal dependent phosphohydrolase" /protein_id="ZP_05429996.1" /db_xref="GI:256005025" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /translation="MKGKIEINMPKDVSYIIDTLNNRGFKAYIVGGCIRDAILGKVPA DWDVATDAQPEDVKLIFDKIVETGIKHGTVTAVINGCNYEITTFRAPSSAKIPTIKDD LGLRDFTINAMAYHPEEGIIDPFLGMQDMEKSVIRAVGSPEDRFHEDPLRMLRAVRLS STLGFEIDRSVLSAIKENCKLIEKVSPERIRDELSKILISDRPKNFLVLRETGLLKYV LPEFDICFDTGQNHPYHVYNVGMHTLETVSNIESNLVLRWTMLLHDIGKPVVKTTDQN GTDHFYGHPEESVNIADKIMKRLRFDNKTTNKVLRLIKHHDRRIEPNQKSVRKAVSII GKDIFPDLLKVQEADKKGQNPQYLDERLKVLDEIKDIFFNLEKEGQILNLKDLALNGN DLLAMGFEQSREIGIILRELYNIVLDNPEMNTKEKLTEIVENIRKKVLKHRKISSEVY S" misc_feature 20853..21224 /locus_tag="ClothDRAFT_1857" /note="Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398" /db_xref="CDD:143388" misc_feature 20871..22124 /locus_tag="ClothDRAFT_1857" /note="tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299" /db_xref="CDD:183958" misc_feature order(20916..20921,20928..20933,20958..20960,20964..20966, 21036..21038,21075..21077,21090..21092,21138..21149, 21156..21158) /locus_tag="ClothDRAFT_1857" /note="active site" /db_xref="CDD:143388" misc_feature order(20916..20921,20928..20930,20958..20960,20964..20966, 21138..21146,21156..21158) /locus_tag="ClothDRAFT_1857" /note="NTP binding site; other site" /db_xref="CDD:143388" misc_feature order(20958..20960,20964..20966,21075..21077) /locus_tag="ClothDRAFT_1857" /note="metal binding triad; metal-binding site" /db_xref="CDD:143388" misc_feature 21528..21839 /locus_tag="ClothDRAFT_1857" /note="Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076" /db_xref="CDD:185790" gene 22178..23110 /locus_tag="ClothDRAFT_1858" CDS 22178..23110 /locus_tag="ClothDRAFT_1858" /inference="protein motif:PFAM:PF00561" /note="PFAM: alpha/beta hydrolase fold; KEGG: scl:sce0898 hydrolase" /codon_start=1 /transl_table=11 /product="alpha/beta hydrolase fold protein" /protein_id="ZP_05429997.1" /db_xref="GI:256005026" /db_xref="InterPro:IPR000073" /translation="MIAQTFTFKAKDKTEIFVYKWMPEKGIKGIVQIAHGIGEHGGRY ENFARDLSNSGYMVYANDHREHGKTAKTASQHNLQKRRIWNLMVEDLRQLTEIIRNEN PNVPVFFFGHSMGSFLLRQYLYKYPNSIDGAILAGTGIYEKLLVDAGILIIKRLISKG ADKKKSYYIINKILFRGFNSKIDNPKTNFDWLSRDVKVVLDFINDPFCTIPRSVDFFL EFLYGIKEVHKKENIEKIPKNTPIFIISGDKDPVGHWGSDIPTLARLYGKTGIKDVTY KLYKDARHELVNELNRDEVINDIIMWMNKRNPSA" misc_feature 22193..23107 /locus_tag="ClothDRAFT_1858" /note="Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267" /db_xref="CDD:32448" misc_feature 22214..22465 /locus_tag="ClothDRAFT_1858" /note="Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031" /db_xref="CDD:187168" misc_feature 22349..23077 /locus_tag="ClothDRAFT_1858" /note="Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031" /db_xref="CDD:187168" gene complement(23248..24783) /locus_tag="ClothDRAFT_1859" CDS complement(23248..24783) /locus_tag="ClothDRAFT_1859" /inference="protein motif:TFAM:TIGR00973" /note="TIGRFAM: 2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: sat:SYN_00090 2-isopropylmalate synthase" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="ZP_05429998.1" /db_xref="GI:256005027" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /translation="MRRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEP GFPLTSPGDFEAVQRIAREVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSS DIQIKHQLGKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDN GATVINIPDTVGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAM NGAQQIECTINGVGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYM GIPIPVNKPIVGKNVFTHESGIHQDGVLKERSTYEVIDPRLVGRDDSVILLGKHSGRH ALKVEAEKLGYDLDEERLNKLFNDFKKLTDVKKNVTTADLESLIIESAAKAVEEAYVL EKIRVVSGNIETPSAKVVIKDSKGNLLEAEQTGNGPVDAVFKAINSVIKETENLTLYK YSVSAVTEEMESLGEVSVTLREKEKLYTGIGTHTDIITSSAIAYIDAINKAIAANARA QKN" misc_feature complement(23314..24783) /locus_tag="ClothDRAFT_1859" /note="2-isopropylmalate synthase; Validated; Region: PRK00915" /db_xref="CDD:179166" misc_feature complement(23962..24768) /locus_tag="ClothDRAFT_1859" /note="2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940" /db_xref="CDD:163678" misc_feature complement(order(24175..24177,24181..24183,24274..24276, 24280..24282,24364..24366,24370..24372,24496..24498, 24562..24564,24655..24657,24736..24738,24745..24750)) /locus_tag="ClothDRAFT_1859" /note="active site" /db_xref="CDD:163678" misc_feature complement(order(24655..24657,24745..24750)) /locus_tag="ClothDRAFT_1859" /note="catalytic residues; other site" /db_xref="CDD:163678" misc_feature complement(order(24175..24177,24181..24183)) /locus_tag="ClothDRAFT_1859" /note="metal-binding site" /db_xref="CDD:163678" misc_feature complement(23314..23622) /locus_tag="ClothDRAFT_1859" /note="LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502" /db_xref="CDD:149524" gene complement(25600..26874) /locus_tag="ClothDRAFT_1860" CDS complement(25600..26874) /locus_tag="ClothDRAFT_1860" /inference="protein motif:TFAM:TIGR00229" /note="KEGG: scl:sce2947 phosphate sensory box histidine kinase PhoR; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein" /codon_start=1 /transl_table=11 /product="PAS/PAC sensor signal transduction histidine kinase" /protein_id="ZP_05429999.1" /db_xref="GI:256005028" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /translation="MIWLYSILIFIMALIITVIVSLRIAGLVIRPLNDIISVSKEITN GNYSRRIKLKSKDELGQLAVHFNKMASKLERTISDLNTKKIELESIVESITNGIVAVD GNNKVILINPAAFTVFNLDADAEILGDDIENHIKNSQINSLLKDAIQKNKPLEAEVAI DGRVLLVNASPIRPKDSDIDNSGGIVFIQDITKVRKLEQIRTEFVSNVTHELKTPITS IRGFIETLKNGAMNNPVVAERFLEIIDIEAERLHELINDILLLSEIETKLKDTNLEIF DLKSMVDDVFKVMQNIAKEKKISLNNNVRDEVLMKANINRMKQLIMNLVDNGIKYNVQ NGSVSVDGYREDGKVVISVKDTGIGIPSAHIPRIFERFYRVDKGRSRGMGGTGLGLSI VKHIVNLYNGEIKVNSVVGEGTEFIVKIPCQP" misc_feature complement(26650..26793) /locus_tag="ClothDRAFT_1860" /note="Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225" /db_xref="CDD:100122" misc_feature complement(order(26656..26661,26668..26673,26677..26682, 26689..26694,26698..26703,26749..26751,26755..26760, 26767..26772,26776..26781,26788..26793)) /locus_tag="ClothDRAFT_1860" /note="dimerization interface; other site" /db_xref="CDD:100122" misc_feature complement(25615..26637) /locus_tag="ClothDRAFT_1860" /note="phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966" /db_xref="CDD:163090" misc_feature complement(26248..>26589) /locus_tag="ClothDRAFT_1860" /note="CHASE4 domain; Region: CHASE4; cl01308" /db_xref="CDD:154325" misc_feature complement(26089..26283) /locus_tag="ClothDRAFT_1860" /note="Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082" /db_xref="CDD:119399" misc_feature complement(order(26101..26103,26113..26115,26122..26124, 26134..26136,26143..26145,26155..26157,26209..26211, 26218..26220,26230..26232,26239..26241,26251..26253, 26263..26265)) /locus_tag="ClothDRAFT_1860" /note="dimer interface; other site" /db_xref="CDD:119399" misc_feature complement(26245..26247) /locus_tag="ClothDRAFT_1860" /note="phosphorylation site" /db_xref="CDD:119399" misc_feature complement(25615..25926) /locus_tag="ClothDRAFT_1860" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature complement(order(25627..25629,25633..25638,25651..25653, 25657..25659,25705..25716,25795..25800,25804..25806, 25810..25812,25816..25818,25885..25887,25894..25896, 25906..25908)) /locus_tag="ClothDRAFT_1860" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature complement(25894..25896) /locus_tag="ClothDRAFT_1860" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature complement(order(25708..25710,25714..25716,25798..25800, 25804..25806)) /locus_tag="ClothDRAFT_1860" /note="G-X-G motif; other site" /db_xref="CDD:28956" gene complement(26871..27368) /locus_tag="ClothDRAFT_1861" CDS complement(26871..27368) /locus_tag="ClothDRAFT_1861" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: dal:Dalk_1426 PAS/PAC sensor signal transduction histidine kinase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430000.1" /db_xref="GI:256005029" /translation="MKKKIFKYYLLLILIILSVTVIFIPKVSRKFYTQEVENKLEGIA FSIEYYLLNEAKNGEIDFDFIAKDYAAKYNQNSTFQGESLRITFISYDGKVLGDSDAN FNQMENHLSRKEIQDALKGNVGKDIRSSKTLKLDLLYMAIPVEELNVIARVSVPLVQI KKLTD" gene complement(27371..28090) /locus_tag="ClothDRAFT_1862" CDS complement(27371..28090) /locus_tag="ClothDRAFT_1862" /inference="protein motif:PFAM:PF00072" /note="PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: sat:SYN_00981 response regulator" /codon_start=1 /transl_table=11 /product="two component transcriptional regulator, winged helix family" /protein_id="ZP_05430001.1" /db_xref="GI:256005030" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /translation="MYDMAKKLIYIVEDEKHIQELLRFNLEENGYEVECFEDGETMFE VVERKKPDLFVLDIMLPGVDGFEICKKIKENYDLKKIPIIMLTAKNDELDRVLGLELG ADDYISKPFSVREFVARVKVAFRRQADSFENSPKRVNVGRITIDFERREVYKDNQIIE MTFKEFELLKLLIMNRGKVLSRDMLLQKIWGFDFFGETRTVDVHIRYLRQKIEDDDNN PVYIETVRGIGYRFSDKEVRE" misc_feature complement(27383..28066) /locus_tag="ClothDRAFT_1862" /note="Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745" /db_xref="CDD:31088" misc_feature complement(27719..28060) /locus_tag="ClothDRAFT_1862" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature complement(order(27761..27766,27773..27775,27830..27832, 27896..27898,27920..27922,28049..28054)) /locus_tag="ClothDRAFT_1862" /note="active site" /db_xref="CDD:29071" misc_feature complement(27920..27922) /locus_tag="ClothDRAFT_1862" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature complement(order(27896..27904,27908..27913)) /locus_tag="ClothDRAFT_1862" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature complement(27758..27766) /locus_tag="ClothDRAFT_1862" /note="dimerization interface; other site" /db_xref="CDD:29071" misc_feature complement(27395..27679) /locus_tag="ClothDRAFT_1862" /note="Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383" /db_xref="CDD:29475" misc_feature complement(order(27404..27406,27419..27421,27455..27460, 27482..27484,27491..27493,27545..27550,27605..27607)) /locus_tag="ClothDRAFT_1862" /note="DNA binding site" /db_xref="CDD:29475" gene complement(28145..28336) /locus_tag="ClothDRAFT_1863" CDS complement(28145..28336) /locus_tag="ClothDRAFT_1863" /inference="protein motif:COG:COG1117" /note="KEGG: shl:Shal_4279 phosphate ABC transporter, ATPase subunit" /codon_start=1 /transl_table=11 /product="ABC-type phosphate transport system ATPase component-like protein" /protein_id="ZP_05430002.1" /db_xref="GI:256005031" /translation="MNDLLNDAKTTEKVYFHSLNVYKEYDIVELRKRVGMVFQKPNPF PMEIQMASCCKIQVIVKYI" misc_feature complement(<28190..>28336) /locus_tag="ClothDRAFT_1863" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" misc_feature complement(28220..28231) /locus_tag="ClothDRAFT_1863" /note="Q-loop/lid; other site" /db_xref="CDD:72971" gene complement(28421..29965) /locus_tag="ClothDRAFT_1864" CDS complement(28421..29965) /locus_tag="ClothDRAFT_1864" /inference="protein motif:PFAM:PF00614" /note="PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; KEGG: dat:HRM2_06130 Cls" /codon_start=1 /transl_table=11 /product="phospholipase D/Transphosphatidylase" /protein_id="ZP_05430003.1" /db_xref="GI:256005032" /db_xref="InterPro:IPR001736" /translation="MWSRIKSIVKFLYHRVVLISLAILIQLIALVSVVLKFNDYFVFF YWACLIISMIAVFLILNGKSNPSYKIAWIIPILLFPIFGGLFYIFFGGKKLSRRERRK LKSIGMKVENALVLQPEVLSEIMLHDDGAAVQSRYIQNVAHYPPHKNSTAEYLSIGEK KYEKLKEELKKAKHFIFMEYFIIQEGIMWNSILEILVEKAKNGVDVRLIYDDMGCLLF LPRNYNKKLESMGIKCCVFNPVSPILSAKINNRDHRKIAIIDGHTAFTGGINLADEYI NEIKKHGHWKDTAIMIKGEAVWNMTVMFLSMWDYLRGIEEDFEKFRYKFKKESEIEDG YFQPFSDSPFDDETVGETVYLNLLNKAKRYVYITTPYLVIDYKMTQALASAAKSGIDV RIITPHIEDKWYVHAVTRSNYRFLVESGVKIYEYTPGFIHSKTLVSDDEYAVVGTINM DYRSFYLHFECGVWTYKSKSVLDIKEDFLSTLDVCTEITMDMIKKTKWYKTLIGTLLR VFAPLM" sig_peptide complement(29870..29965) /locus_tag="ClothDRAFT_1864" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.713) with cleavage site probability 0.552 at residue 32" misc_feature complement(29087..29446) /locus_tag="ClothDRAFT_1864" /note="Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138" /db_xref="CDD:29051" misc_feature complement(order(29123..29125,29156..29158,29162..29164, 29201..29203,29207..29209)) /locus_tag="ClothDRAFT_1864" /note="active site" /db_xref="CDD:29051" misc_feature complement(order(29156..29158,29162..29167,29186..29188, 29201..29203,29207..29209)) /locus_tag="ClothDRAFT_1864" /note="signature motif; other site" /db_xref="CDD:29051" misc_feature complement(28577..28957) /locus_tag="ClothDRAFT_1864" /note="Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138" /db_xref="CDD:29051" misc_feature complement(order(28586..28588,28619..28621,28625..28627, 28664..28666,28670..28672)) /locus_tag="ClothDRAFT_1864" /note="active site" /db_xref="CDD:29051" misc_feature complement(order(28619..28621,28625..28630,28649..28651, 28664..28666,28670..28672)) /locus_tag="ClothDRAFT_1864" /note="signature motif; other site" /db_xref="CDD:29051" gene complement(30005..30823) /locus_tag="ClothDRAFT_1865" CDS complement(30005..30823) /locus_tag="ClothDRAFT_1865" /inference="protein motif:PFAM:PF01501" /note="PFAM: glycosyl transferase family 8; KEGG: pmu:PM1139 hypothetical protein" /codon_start=1 /transl_table=11 /product="glycosyl transferase family 8" /protein_id="ZP_05430004.1" /db_xref="GI:256005033" /db_xref="InterPro:IPR002495" /translation="MKSILVTLDSNYLKPLKVMLKSLFINNPNEEFDIYLMHSSIKEE ELEDLDRFIEAEGGRLKIVQINDSYFEDAPTLLHYTKAMYYRLLAFKFLPEELDRILY LDPDILVINPIDELYNMDIDNYLYAAAYHNIITIKRINRIRLNAYDIKEYYNSGVLLM NLKLQRETISEEEIFDFVKNNRSKLIMPDQDIINSLYSKKIKSIDEKLYNYDARYYSY YKITSNGKCDMDYVINNTVFIHFCGKKKPWKKSYSGKFHSLYKHYEKLAMNTKY" misc_feature complement(30098..30820) /locus_tag="ClothDRAFT_1865" /note="A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194" /db_xref="CDD:133037" misc_feature complement(order(30098..30100,30104..30106,30185..30187, 30254..30259,30356..30364,30431..30433,30506..30514, 30566..30568,30575..30577,30788..30793,30797..30805)) /locus_tag="ClothDRAFT_1865" /note="Ligand binding site; other site" /db_xref="CDD:133037" misc_feature complement(order(30104..30106,30506..30508,30512..30514)) /locus_tag="ClothDRAFT_1865" /note="metal-binding site" /db_xref="CDD:133037" gene complement(31058..33586) /locus_tag="ClothDRAFT_1866" CDS complement(31058..33586) /locus_tag="ClothDRAFT_1866" /inference="protein motif:PFAM:PF00404" /note="PFAM: cellulosome protein dockerin type I; glycosyl hydrolase BNR repeat-containing protein; Kelch repeat-containing protein; KEGG: cja:CJA_2477 endo-1,4-beta-glucanase/xyloglucanase, putative, gly74A" /codon_start=1 /transl_table=11 /product="cellulosome protein dockerin type I" /protein_id="ZP_05430005.1" /db_xref="GI:256005034" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /db_xref="InterPro:IPR002860" /db_xref="InterPro:IPR006652" /translation="MVKKFTSKIKAAVFAAVVAATAIFGPAISSQAVTSVPYKWDNVV IGGGGGFMPGIVFNETEKDLIYARADIGGAYRWDPSTETWIPLLDHFQMDEYSYYGVE SIATDPVDPNRVYIAAGMYTNDWLPNMGAILRSTDRGETWEKTILPFKMGGNMPGRSM GERLAIDPNDNRILYLGTRCGNGLWRSTDYGVTWSKVESFPNPGTYIYDPNFDYTKDI IGVVWVVFDKSSSTPGNPTKTIYVGVADKNESIYRSTDGGVTWKAVPGQPKGLLPHHG VLASNGMLYITYGDTCGPYDGNGKGQVWKFNTRTGEWIDITPIPYSSSDNRFCFAGLA VDRQNPDIIMVTSMNAWWPDEYIFRSTDGGATWKNIWEWGMYPERILHYEIDISAAPW LDWGTEKQLPEINPKLGWMIGDIEIDPFNSDRMMYVTGATIYGCDNLTDWDRGGKVKI EVKATGIEECAVLDLVSPPEGAPLVSAVGDLVGFVHDDLKVGPKKMHVPSYSSGTGID YAELVPNFMALVAKADLYDVKKISFSYDGGRNWFQPPNEAPNSVGGGSVAVAADAKSV IWTPENASPAVTTDNGNSWKVCTNLGMGAVVASDRVNGKKFYAFYNGKFYISTDGGLT FTDTKAPQLPKSVNKIKAVPGKEGHVWLAAREGGLWRSTDGGYTFEKLSNVDTAHVVG FGKAAPGQDYMAIYITGKIDNVLGFFRSDDAGKTWVRINDDEHGYGAVDTAITGDPRV YGRVYIATNGRGIVYGEPASDEPVPTPPQVDKGLVGDLNGDNRINSTDLTLMKRYILK SIEDLPVEDDLWAADINGDGKINSTDYTYLKKYLLQAIPELPKK" sig_peptide complement(33488..33586) /locus_tag="ClothDRAFT_1866" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.838 at residue 33" misc_feature complement(<32948..33199) /locus_tag="ClothDRAFT_1866" /note="VPS10 domain; Region: VPS10; smart00602" /db_xref="CDD:128865" misc_feature complement(<32486..33037) /locus_tag="ClothDRAFT_1866" /note="Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922" /db_xref="CDD:92329" misc_feature complement(order(32648..32656,32663..32671)) /locus_tag="ClothDRAFT_1866" /note="Asp-box motif; other site" /db_xref="CDD:29333" misc_feature complement(<31337..31711) /locus_tag="ClothDRAFT_1866" /note="Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447" /db_xref="CDD:34127" misc_feature complement(31196..31258) /locus_tag="ClothDRAFT_1866" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature complement(31088..31150) /locus_tag="ClothDRAFT_1866" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene complement(33935..34381) /locus_tag="ClothDRAFT_1867" CDS complement(33935..34381) /locus_tag="ClothDRAFT_1867" /inference="protein motif:TFAM:TIGR01909" /note="TIGRFAM: C_GCAxxG_C_C family protein; KEGG: sfu:Sfum_2781 C_GCAxxG_C_C family protein" /codon_start=1 /transl_table=11 /product="C_GCAxxG_C_C family protein" /protein_id="ZP_05430006.1" /db_xref="GI:256005035" /db_xref="InterPro:IPR010181" /translation="MNGKSERAVELFKEGYNCSQAVLAAYCEDVGIDMKTALMIASPF GGGIGRLREVCGAASAMFMIAGLKYGYVDPKDMNAKKEHYELVQKLVERFKEENGSII CRELLGLNVVHDKPEPEKRTEGYYKKRPCAEIVRSAAEIVDELLKT" misc_feature complement(33944..34336) /locus_tag="ClothDRAFT_1867" /note="Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920" /db_xref="CDD:158779" gene complement(34493..35740) /locus_tag="ClothDRAFT_1868" CDS complement(34493..35740) /locus_tag="ClothDRAFT_1868" /inference="protein motif:PFAM:PF07745" /note="PFAM: glycosyl hydrolase 53 domain protein; cellulosome protein dockerin type I; KEGG: asa:ASA_2386 arabinogalactan endo-1,4-beta-galactosidase" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase 53 domain protein" /protein_id="ZP_05430007.1" /db_xref="GI:256005036" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /db_xref="InterPro:IPR011683" /translation="MLSKITKLTVIFILILSVTFLSMPKTYTQAAPTFAKGADVSWLP EMEANGYKFYNDDGIEQDCLQILKDHGIDSIRLRVWVNPPNGYCNKEETIKMALRAKK MGFRIMINFHYSDSWADPGKQTKPAAWAKYDFNGLMKAVYDYTYDVMSALKANGITPE WVQVGNETNNGMLWEDGKATNSMRNFAWLINCGYDAVKAVSPETKVIVHIANGYDNAL YRWIFDGITANGARFDVIGMSLYPTASDWPQLTNQCLNNMKDMISRYGKEIMICEIGM DYWEAQACKDFITDIIQKTKSLPDNKGLGVFYWEPQCYNWQYYNKGAFDLSGKPTIAL DAFLTSDTPDNLIYGDLNGDGRVNSTDYTLLKRYLLGAIQTFPYERGIKAADLNLDGR INSTDYTVLKRYLLNAIPSLPVK" sig_peptide complement(35654..35740) /locus_tag="ClothDRAFT_1868" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.618 at residue 29" misc_feature complement(34730..35638) /locus_tag="ClothDRAFT_1868" /note="Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672" /db_xref="CDD:125185" misc_feature complement(34631..34693) /locus_tag="ClothDRAFT_1868" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature complement(34523..34585) /locus_tag="ClothDRAFT_1868" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene 38301..38423 /locus_tag="ClothDRAFT_1869" CDS 38301..38423 /locus_tag="ClothDRAFT_1869" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430008.1" /db_xref="GI:256005037" /translation="MFTWDTSVYPWVRFYRTYEELKLDESNSSTELGDTFLSYL" gene complement(40267..40443) /locus_tag="ClothDRAFT_1870" CDS complement(40267..40443) /locus_tag="ClothDRAFT_1870" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430009.1" /db_xref="GI:256005038" /translation="MVSIPHRYDKNEEPKEEKPADKLFQFLIGTIKTCSKLLVGGVYM AFQFLIGTIKTVHF" gene 41631..41963 /locus_tag="ClothDRAFT_1871" CDS 41631..41963 /locus_tag="ClothDRAFT_1871" /inference="similar to AA sequence:KEGG:Dalk_0136" /note="KEGG: dal:Dalk_0136 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430010.1" /db_xref="GI:256005039" /translation="MLNEVDYLDDILAKFVDVGVSGATILHSQGMASAIVNSENNKIS LFSALKSIIENIRPYNKTIFTVLESEELVEKAVSAVQSVIGKAPTSGVGFMFTVPIGK IYPMGLQE" gene complement(41996..42475) /locus_tag="ClothDRAFT_1872" CDS complement(41996..42475) /locus_tag="ClothDRAFT_1872" /inference="protein motif:PFAM:PF02742" /note="PFAM: iron dependent repressor; regulatory protein MarR; SMART: iron dependent repressor; regulatory protein MarR; KEGG: dal:Dalk_2732 iron (metal) dependent repressor, DtxR family" /codon_start=1 /transl_table=11 /product="iron (metal) dependent repressor, DtxR family" /protein_id="ZP_05430011.1" /db_xref="GI:256005040" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001367" /translation="MENSEFHTVRGYQLIEQEKKLLTSAMEDYLEMIFRNIKKEGYMR INTLAEMLNVRPSSATKMVQKLSEKGFVEYKRYGIITLTEKGKALGEFLLKRHNIIEK FLRSIGISDNLLIETELIEHNLSVDTLRSIDELNSFFEEYPEILEKFRRYKNKKAKK" misc_feature complement(42035..42415) /locus_tag="ClothDRAFT_1872" /note="manganese transport transcriptional regulator; Provisional; Region: PRK03902" /db_xref="CDD:179669" misc_feature complement(42242..42409) /locus_tag="ClothDRAFT_1872" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:185792" misc_feature complement(42047..42229) /locus_tag="ClothDRAFT_1872" /note="Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742" /db_xref="CDD:145737" gene 42635..42874 /locus_tag="ClothDRAFT_1873" CDS 42635..42874 /locus_tag="ClothDRAFT_1873" /inference="protein motif:PFAM:PF04023" /note="PFAM: FeoA family protein; KEGG: dvm:DvMF_1016 FeoA family protein" /codon_start=1 /transl_table=11 /product="FeoA family protein" /protein_id="ZP_05430012.1" /db_xref="GI:256005041" /db_xref="InterPro:IPR007167" /translation="MAGKQITLASLPIGKKARVKSLTLDGTIRRRIMDLGLVSDTIVE ALQKSPSGDPTAYHIRGAVIALRSEEASKIMVEVN" misc_feature 42650..42868 /locus_tag="ClothDRAFT_1873" /note="FeoA domain; Region: FeoA; cl00838" /db_xref="CDD:186215" gene 42957..43403 /locus_tag="ClothDRAFT_1874" CDS 42957..43403 /locus_tag="ClothDRAFT_1874" /inference="protein motif:PFAM:PF01926" /note="PFAM: GTP-binding protein HSR1-related; KEGG: afw:Anae109_4105 ferrous iron transport protein B" /codon_start=1 /transl_table=11 /product="GTP-binding protein HSR1-related protein" /protein_id="ZP_05430013.1" /db_xref="GI:256005042" /db_xref="InterPro:IPR002917" /db_xref="InterPro:IPR006073" /translation="MGLTSQSTGAGVLENKLTIVKSTPVDKVIALAGNPNVGKSTVFN SLTGLNQHTGNWPGKTVTNAQGRYKHKDKNFIMVDIPGTYSLMANSVEEEVARDFVCF GQPDATVVVTDATCLERNLNLVLQTLEITNKVVVCVNLIDEAERKK" misc_feature 43047..>43397 /locus_tag="ClothDRAFT_1874" /note="Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879" /db_xref="CDD:133280" misc_feature 43053..43076 /locus_tag="ClothDRAFT_1874" /note="G1 box; other site" /db_xref="CDD:133280" misc_feature order(43062..43064,43068..43079,43371..43376,43380..43382) /locus_tag="ClothDRAFT_1874" /note="GTP/Mg2+ binding site; other site" /db_xref="CDD:133280" misc_feature 43131..43145 /locus_tag="ClothDRAFT_1874" /note="Switch I region; other site" /db_xref="CDD:133280" misc_feature 43134..43136 /locus_tag="ClothDRAFT_1874" /note="G2 box; other site" /db_xref="CDD:133280" misc_feature 43191..43202 /locus_tag="ClothDRAFT_1874" /note="G3 box; other site" /db_xref="CDD:133280" misc_feature order(43200..43256,43266..43271) /locus_tag="ClothDRAFT_1874" /note="Switch II region; other site" /db_xref="CDD:133280" misc_feature 43371..43382 /locus_tag="ClothDRAFT_1874" /note="G4 box; other site" /db_xref="CDD:133280" gene 43490..45106 /locus_tag="ClothDRAFT_1875" CDS 43490..45106 /locus_tag="ClothDRAFT_1875" /inference="protein motif:PFAM:PF02421" /note="PFAM: Ferrous iron transport protein B domain protein; nucleoside recognition domain protein; Ferrous iron transport B domain protein; KEGG: sat:SYN_02208 Fe2+ transport system protein B" /codon_start=1 /transl_table=11 /product="Ferrous iron transport protein B domain protein" /protein_id="ZP_05430014.1" /db_xref="GI:256005043" /db_xref="InterPro:IPR011619" /db_xref="InterPro:IPR011640" /db_xref="InterPro:IPR011642" /translation="MDAVYEISTKETTSHPIKITYDDIVEEAIKMIQPKIETIAGEKI NSRWVALKLLDNDGALLESLNNFLGFNLLDDNELAELVDMAKKHLLNNGIGQNQLRDK IVTRLVKIAEEICQSVITFENKQYDHLDRKIDKILTSRVFGIPVMLAMLGVIFWITIT GANYPSQMLSTLFFWIEERLTDFFVWAKAPKWLHGLLVTGAYRTLAWVVSVMLPPMAI FFPLFTLLEDLGYLPRVAFNLDNFFKKACAHGKQSLTMCMGFGCNAAGVIGCRIIDSP RERLIATITNNFVPCNGRFPTLIAIITMFFVGNFAGFSQSVLSTLFLTGVILLGIVMT LLVSKLLSKTILKGLPSSFALELPPYRKPQIGRIIVRSIFDRTLFVLGRAVSVAIPAG FVIWIMANIYVGEQSLLSLCAGFLDPFARLIGLDGYILMAFILGFPANEIVVPIIIMS YMSSESMMELENLNQLKQLLVDNGWTWVTALCVMLFSLMHWPCSTTCLTIRKETQSWK WTLVSFLVPTLSGIVICFIVANLARLLALV" misc_feature <43508..45094 /locus_tag="ClothDRAFT_1875" /note="Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370" /db_xref="CDD:30719" misc_feature 44114..44395 /locus_tag="ClothDRAFT_1875" /note="Nucleoside recognition; Region: Gate; cl00486" /db_xref="CDD:186029" misc_feature 44453..44617 /locus_tag="ClothDRAFT_1875" /note="Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664" /db_xref="CDD:148974" gene complement(45138..47249) /locus_tag="ClothDRAFT_1876" CDS complement(45138..47249) /locus_tag="ClothDRAFT_1876" /inference="protein motif:PFAM:PF08757" /note="PFAM: Spore coat protein CotH; KEGG: dal:Dalk_4022 spore coat protein CotH" /codon_start=1 /transl_table=11 /product="Spore coat protein CotH" /protein_id="ZP_05430015.1" /db_xref="GI:256005044" /db_xref="InterPro:IPR014867" /translation="MDENVNLKMVFKIVVTILCIALLITGMALVPKAFPNAAEADAQP DYIYKIFNDNVVNEINIEMDENDFEWLLENATLEEYRSCNVTINGETFYNVGIRPKGN SSLSQIARSDSKRFSFKLDFSEYIDGQTYYGAEKIVLNNIMSDKTYMKEYLSYKLFDF MGVPSSACAYSNIRINGKDWGLYLAVEVIDESYIERHFGSVNGNLYKPEAMEIGGDRG EERGGQQNGGPNAMPFMRGRREQMQNAPGAEQRQNEAGREQVPNQFGMRQMPGGAERE QMPDRPGRDQIPNRDGTNQIQNQETKEQNSNESRMQQIPNGFGAQGRFGGFIGGFGRM GARGGADLKYIDDSPSSYWAIRNNAVFKTTTDADFKKVIEMIKKLNEGTDLEKYLDVD EILRFWAVNTFLVNLDGYSGGMYHNYYLYEENGVFLILPWDFNLSFAGFGINDASRAV NFPIDNPVTGNLENAPLIGKLLEVPEYRERYHGYLREIVEKYIYSGVYENSINRINAL ISDYVKNDATAFYTFEEYQKGVQAILTFGKDRAKSILAQLEGSQPSTSYGSIETTLNL SDMGGMGGMRGGMQPPRNMQMPDGMQIPGDMRMPDGIQIPGGMQIPDGIQMPDDMQMP DGMQIPDGMQMPDGGQMPNGMQMPNGMQPPGNMRFRGGMEMFRDNQQSETQSTVLILS VAALIPGLIFVAKFKRRKYRA" misc_feature complement(<46629..47102) /locus_tag="ClothDRAFT_1876" /note="Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337" /db_xref="CDD:34914" misc_feature complement(<45903..>46223) /locus_tag="ClothDRAFT_1876" /note="Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337" /db_xref="CDD:34914" misc_feature complement(45618..>46157) /locus_tag="ClothDRAFT_1876" /note="CotH protein; Region: CotH; pfam08757" /db_xref="CDD:149727" gene complement(47288..47974) /locus_tag="ClothDRAFT_1877" CDS complement(47288..47974) /locus_tag="ClothDRAFT_1877" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: bba:Bd0818 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430016.1" /db_xref="GI:256005045" /translation="MRNQINFNDIFKSSFLEKVSSVSLLDAAIAFGLAFCIGLFIYFV YKKTYKGVMYSRTFSISLIALTMITTLMILAVTSNVVLSLGMVGALSIVRFRSAIKDP MDIAYLFWSIAVGIVLGAGLIPLAVFGSLFIGIILVLFVNRNSTDNPYILVVNCEDDK AESNVMNIIKDKVRKYVVKSKTITGGKGIEVAVEVRLKSMETEFVNEISRQNGVLSAV MVSYNGDYMS" misc_feature complement(47312..>47755) /locus_tag="ClothDRAFT_1877" /note="Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285" /db_xref="CDD:31476" gene complement(48004..48690) /locus_tag="ClothDRAFT_1878" CDS complement(48004..48690) /locus_tag="ClothDRAFT_1878" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: dat:HRM2_21170 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430017.1" /db_xref="GI:256005046" /translation="MEKVKFRHEIKHYINAGDCLLLRRKLRCVMKTDSNAGPDGSYLV RSLYFDTPADKALMEKIDGVDNREKIRIRLYNHDNLFIKLEKKIKVNGLTAKFSANIT KEQCKDILNGNIEWMKNSDDPLLVEIYHKMLHQQLKPRTIVDYIREAYVYNPGNVRVT IDKSIRTGLVSNDLFNRELPTVETLPRQLALLEVKYDEFLPEIINDILQIGDRQKLSV SKYALCRMYY" misc_feature complement(48025..48672) /locus_tag="ClothDRAFT_1878" /note="Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750" /db_xref="CDD:143622" misc_feature complement(order(48106..48108,48112..48114,48664..48666, 48670..48672)) /locus_tag="ClothDRAFT_1878" /note="putative metal binding residues; other site" /db_xref="CDD:143622" misc_feature complement(order(48658..48660,48664..48666,48670..48672)) /locus_tag="ClothDRAFT_1878" /note="signature motif; other site" /db_xref="CDD:143622" misc_feature complement(order(48064..48066,48076..48078,48496..48498, 48505..48507,48667..48669)) /locus_tag="ClothDRAFT_1878" /note="dimer interface; other site" /db_xref="CDD:143622" misc_feature complement(order(48028..48039,48106..48108,48112..48114, 48217..48219,48250..48252,48256..48258,48403..48405, 48409..48411,48424..48426,48430..48432,48472..48474, 48478..48480,48502..48504,48511..48513,48547..48549, 48658..48660)) /locus_tag="ClothDRAFT_1878" /note="polyP binding site; other site" /db_xref="CDD:143622" misc_feature complement(order(48028..48039,48112..48114,48205..48207, 48250..48252,48256..48258,48403..48405,48430..48432, 48472..48474,48478..48480,48547..48549,48658..48660)) /locus_tag="ClothDRAFT_1878" /note="active site" /db_xref="CDD:143622" misc_feature complement(order(48031..48039,48112..48114,48205..48207, 48250..48252,48256..48258,48403..48405,48430..48432, 48472..48474,48478..48480,48547..48549,48658..48660)) /locus_tag="ClothDRAFT_1878" /note="substrate binding site; other site" /db_xref="CDD:143622" misc_feature complement(order(48028..48036,48430..48432,48478..48480, 48547..48549)) /locus_tag="ClothDRAFT_1878" /note="acceptor-phosphate pocket; other site" /db_xref="CDD:143622" gene 48866..49564 /locus_tag="ClothDRAFT_1879" CDS 48866..49564 /locus_tag="ClothDRAFT_1879" /inference="protein motif:PFAM:PF00072" /note="PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: rsp:RSP_1681 two-component transcriptional regulator" /codon_start=1 /transl_table=11 /product="two component transcriptional regulator, winged helix family" /protein_id="ZP_05430018.1" /db_xref="GI:256005047" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /translation="MENKKLIYIADDEINICNIIKSFLVKEGYDVETFTDGRSILEAF NKKPADLLVIDIMMPEIDGFSLCSTIRRQSSVPIIIVSAKDTEPDKIAGLTLGSDDYL TKPFSPMELIARIKSIFRRIELDKMHNDSVREIRIGDIVINVDKKQAEFNGKNIGLTG TEFNLLYYLAKNKNRAVSRSELLDKVWGFENYVETRATDDTIKRLRKKLSDSGSSLKI ETVWGFGFKVNEEG" misc_feature 48884..49561 /locus_tag="ClothDRAFT_1879" /note="Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745" /db_xref="CDD:31088" misc_feature 48890..49222 /locus_tag="ClothDRAFT_1879" /note="Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156" /db_xref="CDD:29071" misc_feature order(48896..48901,49028..49030,49052..49054,49109..49111, 49166..49168,49175..49180) /locus_tag="ClothDRAFT_1879" /note="active site" /db_xref="CDD:29071" misc_feature 49028..49030 /locus_tag="ClothDRAFT_1879" /note="phosphorylation site" /db_xref="CDD:29071" misc_feature order(49037..49042,49046..49054) /locus_tag="ClothDRAFT_1879" /note="intermolecular recognition site; other site" /db_xref="CDD:29071" misc_feature 49175..49183 /locus_tag="ClothDRAFT_1879" /note="dimerization interface; other site" /db_xref="CDD:29071" misc_feature 49268..49546 /locus_tag="ClothDRAFT_1879" /note="Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383" /db_xref="CDD:29475" misc_feature order(49340..49342,49397..49402,49454..49456,49463..49465, 49487..49492,49523..49525,49538..49540) /locus_tag="ClothDRAFT_1879" /note="DNA binding site" /db_xref="CDD:29475" gene 49569..51038 /locus_tag="ClothDRAFT_1880" CDS 49569..51038 /locus_tag="ClothDRAFT_1880" /inference="protein motif:PFAM:PF02518" /note="PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: sse:Ssed_2589 sensor histidine kinase" /codon_start=1 /transl_table=11 /product="histidine kinase" /protein_id="ZP_05430019.1" /db_xref="GI:256005048" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /translation="MKKNTIKWRIFKYNIIAISVLLALTTIVFNITIQSYIKNDIKEQ LSTIAQRVEDTALYRGPDFFPPQEPQRPRPLPGRQNGMFRENNDLFRFYFFLDRSLRE PLSILNADFILLDNNMDIITPPEGDFFKPSGEIANEIISKIKKLDGSKVQEYVYFNVN NTDYISIVKPVSDKNSFGLGWLIIYSSLQKVNQLKLGINMILIVIVLLSALIFAIFSS LAAKKISAPFSSLNQHIRAIAERNFGVKIEMPVDAELQELVNSINIMSEKLESYDKAQ KTFFQNASHEFRTPLMSIQSYAEGIKYDVVDKNTAADIIIDETKRMTHLVEDLLYLSR LDTIEENYRFADLDFKDFINACQERMYGIASKSGINLEVENINEPVVVYADEEKLFRA FANIIGNCIRYANNTVSIVPKIIDRSKIEIVIRDDGPGIDSNELPNIFERFYKGKKGN VGLGLAISKNIIERHNGKITARNSESGAVFTIVLPVKQS" sig_peptide 49569..49661 /locus_tag="ClothDRAFT_1880" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.944) with cleavage site probability 0.542 at residue 31" misc_feature <50217..50381 /locus_tag="ClothDRAFT_1880" /note="Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054" /db_xref="CDD:154171" misc_feature 50385..50570 /locus_tag="ClothDRAFT_1880" /note="Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082" /db_xref="CDD:119399" misc_feature order(50403..50405,50415..50417,50427..50429,50436..50438, 50448..50450,50457..50459,50511..50513,50520..50522, 50532..50534,50541..50543,50553..50555) /locus_tag="ClothDRAFT_1880" /note="dimer interface; other site" /db_xref="CDD:119399" misc_feature 50421..50423 /locus_tag="ClothDRAFT_1880" /note="phosphorylation site" /db_xref="CDD:119399" misc_feature 50733..51020 /locus_tag="ClothDRAFT_1880" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(50751..50753,50763..50765,50772..50774,50838..50840, 50844..50846,50850..50852,50856..50861,50922..50933, 50979..50981,50985..50987,50997..51002,51006..51008) /locus_tag="ClothDRAFT_1880" /note="ATP binding site; other site" /db_xref="CDD:28956" misc_feature 50763..50765 /locus_tag="ClothDRAFT_1880" /note="Mg2+ binding site; other site" /db_xref="CDD:28956" misc_feature order(50850..50852,50856..50858,50922..50924,50928..50930) /locus_tag="ClothDRAFT_1880" /note="G-X-G motif; other site" /db_xref="CDD:28956" gene complement(51080..52030) /locus_tag="ClothDRAFT_1881" CDS complement(51080..52030) /locus_tag="ClothDRAFT_1881" /inference="protein motif:TFAM:TIGR01297" /note="TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein; KEGG: msu:MS1293 MMT1 protein" /codon_start=1 /transl_table=11 /product="cation diffusion facilitator family transporter" /protein_id="ZP_05430020.1" /db_xref="GI:256005049" /db_xref="InterPro:IPR002524" /translation="MIKLLIRWFIKDYQNVDNKKVREAYGVLSGVTGIICNVFLFIVK ITVGLVMNSIAVISDAFNNLSDLGSSLVGILGVKLSNRPPDEEHPHGHGRYEYISSLV VSFIIFGVGLELLRNSFWKIIKPEEVTLSTMSILLLVISVAVKLWMFSYNRYIGKIIN SGINKATAQDSLNDAIATTAVLAGTLIGRFVSFPLDGIMGLIISALIMYTGFGIAKDS VDLLLGLCPNSELIESINSYFLVGEKIKGTHDLKVHDYGPGRISASIHAEVPEGADIV EIHSIIDEIEQRIKNELGIDIVVHMDPVEEKKEDCCNDDK" misc_feature complement(51101..51985) /locus_tag="ClothDRAFT_1881" /note="Cation efflux family; Region: Cation_efflux; cl00316" /db_xref="CDD:185899" gene complement(52156..52926) /locus_tag="ClothDRAFT_1882" CDS complement(52156..52926) /locus_tag="ClothDRAFT_1882" /EC_number="4.2.1.20" /inference="protein motif:TFAM:TIGR00262" /note="KEGG: sat:SYN_01941 tryptophan synthase alpha chain; TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain" /codon_start=1 /transl_table=11 /product="tryptophan synthase, alpha subunit" /protein_id="ZP_05430021.1" /db_xref="GI:256005050" /db_xref="InterPro:IPR002028" /translation="MNKLERAFSNGKAFIPFITAGDPSLEITEQLVYRMAEAGADLIE LGIPFSDPVAEGPVIQEADYRALSAGTTTDKIFDMVGRIRKSCDIPIAFMTYANPIFT YGSEKFLKRCGETGIDALIVPDIPFEEKEELAPFCKEYDVRFISMIAPTSKERIRMIA REAEGFIYCVSSMGVTGVREKIGDDAKEMIKIVKEVRDIPCAVGFGISTPEQAAQMAG FSDGVIVGSAIVKIIAQYGAECIPYVEEYVRKMKNAIK" misc_feature complement(52162..52890) /locus_tag="ClothDRAFT_1882" /note="tryptophan synthase; Region: PLN02591" /db_xref="CDD:178201" misc_feature complement(52171..52890) /locus_tag="ClothDRAFT_1882" /note="Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724" /db_xref="CDD:73386" misc_feature complement(order(52246..52251,52309..52314,52396..52401, 52423..52425,52750..52752,52762..52764,52795..52797)) /locus_tag="ClothDRAFT_1882" /note="substrate binding site; other site" /db_xref="CDD:73386" misc_feature complement(order(52399..52401,52639..52641,52762..52764, 52795..52797)) /locus_tag="ClothDRAFT_1882" /note="active site" /db_xref="CDD:73386" misc_feature complement(order(52639..52641,52762..52764,52795..52797)) /locus_tag="ClothDRAFT_1882" /note="catalytic residues; other site" /db_xref="CDD:73386" misc_feature complement(order(52462..52464,52471..52476,52480..52482, 52540..52542,52549..52551,52555..52560,52624..52626, 52633..52635,52744..52749,52756..52758,52765..52767, 52771..52782)) /locus_tag="ClothDRAFT_1882" /note="heterodimer interface; other site" /db_xref="CDD:73386" gene complement(52919..54103) /locus_tag="ClothDRAFT_1883" CDS complement(52919..54103) /locus_tag="ClothDRAFT_1883" /inference="protein motif:TFAM:TIGR00263" /note="TIGRFAM: tryptophan synthase, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gme:Gmet_2482 tryptophan synthase subunit beta" /codon_start=1 /transl_table=11 /product="tryptophan synthase, beta subunit" /protein_id="ZP_05430022.1" /db_xref="GI:256005051" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /translation="MSKGRFGIHGGQYIPETLMNAVIELEEAYNHFKNDPDFLAELDD LLKNYAGRPSLLYYAEKMTKDLNGAKIYLKREDLNHTGSHKINNVLGQVLLAKRMGKK RVIAETGAGQHGVATATAAALMGLECEIFMGKEDTERQALNVFRMELLGAKVHAVTSG TQTLKDAVNETLREWSRRVHDTHYVLGSVMGPHPFPTIVRDFQSVIGREIKKQIMEKE GKLPDVVMACVGGGSNAIGAFYEFIGDSSVRLIGCEAAGKGLETGKHAATMSKGTLGI FHGMKSYFCQDEYGQIAPVYSISAGLDYPGVGPEHAYLKDIGRAQYVAVTDDEAVEAF EYLSRTEGIIPAIESSHAVAYAMKLAPTMSKDQIIVICLSGRGDKDVAAIARYRGVQI YE" misc_feature complement(52940..54100) /locus_tag="ClothDRAFT_1883" /note="tryptophan synthase, beta chain; Region: PLN02618" /db_xref="CDD:178227" misc_feature complement(52952..54043) /locus_tag="ClothDRAFT_1883" /note="Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446" /db_xref="CDD:107207" misc_feature complement(order(52982..52984,53060..53062,53402..53416, 53540..53542,53768..53770,53849..53854)) /locus_tag="ClothDRAFT_1883" /note="pyridoxal 5'-phosphate binding site; other site" /db_xref="CDD:107207" misc_feature complement(53849..53851) /locus_tag="ClothDRAFT_1883" /note="catalytic residue; other site" /db_xref="CDD:107207" gene complement(54485..56401) /locus_tag="ClothDRAFT_1884" CDS complement(54485..56401) /locus_tag="ClothDRAFT_1884" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430023.1" /db_xref="GI:256005052" /translation="MIVFEWKKVLIKQKGLLCIGIMFLLKIALLFYQGYDSNSIINSN EEGYKYYINLYQGKLTEEKEKSIKAEYDSVTNAQAYLEDLSHKKRNGEIGFKEYEEKS KKYYECLKNADVFNLVYNQYYYAKEAPDVRYIIDWRGWQTLLSHDAPDVLLIVCLLIV MVPLFCNEYESGMYSLLVSSVRGKYKVAIVKLLSAFVLSAGIVILFSVAEYICVDFMV GLDNSTFPLQSLKFFEYSDWYVSLRQAFVIIVLFRIVGAVLFTAFISVVSVISKKTIV ALFTCSTLVFLPYIVYGGTTTLYYLPLPSGLLVGAGYLWGDNYLSAITEEGVDRIILF QKISKNMITLLMLMFVIEIVFLFLTCIVKYSRHTFRLNNFGNKIRKFSCALCVLTILL LILTGCRTEMSEKDNFTFNASEEWRCVKTDEYVISLDPEKNIITAENLDKGEQIVLPK DPFRQDIYETEDRSLKRGYRIRSIFVRDGWCYYLKEILQTDGFQIYGIDLKDFKEELI YNGIQENDKNFFGAFFDRRQDQTSLPSVDYFFLNANYIYYLQGKRLVRIDRNTNSETV LALDVKERSAVYHNGDIYYIDTLNRLSVYKEEDETVNKIDSVYTDQISIEGKRIRYTD LLNDKNIGYYDIET" gene complement(56403..57656) /locus_tag="ClothDRAFT_1885" CDS complement(56403..57656) /locus_tag="ClothDRAFT_1885" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430024.1" /db_xref="GI:256005053" /translation="MIRIVYFEIRKNYLRSYVVIALLSFLLINILIIYKDYLYGPNDL YGYFLPHTAEYQKWWQSYQEMYDKVSGKLTADKARFVVSEYRRLDAMVADGTYSREKQ EGTYTGYIWGDYVFITKYFYRPMKYVSTYESAIKQVIENAKANIEFYSQCGNNFDKSK NEFIVKHYSGRKIDVFHNGKFWGLLFEYDFSDLLIVLLLLLGVAPMFVNEKNTNMDKL ILSSIKGKFSMTFVKVFSIFLYTAFLVIVFSGINFLVCKFLYGLSGIQMPIYAVEAYQ YTPLNCSVGMFYVLQTLLKVVGLFVFATWICLLSALFQRVVYPYAISTLSVVLGIYAS GYVASVETSKTIWALMSPFTLLRANKLFNELLGINIRDTFYLRAHVALIVQIFIVLMI FILIYMIVSIRDLRVIKKLITRESS" gene complement(57674..58534) /locus_tag="ClothDRAFT_1886" CDS complement(57674..58534) /locus_tag="ClothDRAFT_1886" /inference="protein motif:PFAM:PF00005" /note="PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pat:Patl_0358 ABC transporter related" /codon_start=1 /transl_table=11 /product="ABC transporter related protein" /protein_id="ZP_05430025.1" /db_xref="GI:256005054" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /translation="MELKLENITKFYGKQCALDNFNGVFTEGIYGLLGPNGAGKTTLI NIIIGVLEASKGAILLDGSDVKKMGTKYLDKVGYLPQEPTFYKNFRVDEFLKYMCAIK GIPSKHVDSRIEEVLELVNLTDSYKKKVGALSGGMRQRLGIGQAILNRPDILILDEPT AGLDPGERIRFRNIISKLSKDRIVLLATHIVSDVEYIAKEVLILKKGKLVKKGTTKEL ERTVEGKIWNVTVSETDVEKYMHKYLIANIKRLEDKLQLRIVSESRPDGIAEAVAPSL EDVFLSIMEQ" misc_feature complement(57680..58534) /locus_tag="ClothDRAFT_1886" /note="ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131" /db_xref="CDD:31326" misc_feature complement(57941..58528) /locus_tag="ClothDRAFT_1886" /note="ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264" /db_xref="CDD:73023" misc_feature complement(58412..58435) /locus_tag="ClothDRAFT_1886" /note="Walker A/P-loop; other site" /db_xref="CDD:73023" misc_feature complement(order(57968..57970,58061..58066,58292..58294, 58409..58417,58421..58426)) /locus_tag="ClothDRAFT_1886" /note="ATP binding site; other site" /db_xref="CDD:73023" misc_feature complement(58292..58303) /locus_tag="ClothDRAFT_1886" /note="Q-loop/lid; other site" /db_xref="CDD:73023" misc_feature complement(58109..58138) /locus_tag="ClothDRAFT_1886" /note="ABC transporter signature motif; other site" /db_xref="CDD:73023" misc_feature complement(58061..58078) /locus_tag="ClothDRAFT_1886" /note="Walker B; other site" /db_xref="CDD:73023" misc_feature complement(58043..58054) /locus_tag="ClothDRAFT_1886" /note="D-loop; other site" /db_xref="CDD:73023" misc_feature complement(57962..57982) /locus_tag="ClothDRAFT_1886" /note="H-loop/switch region; other site" /db_xref="CDD:73023" gene complement(58536..60641) /locus_tag="ClothDRAFT_1887" CDS complement(58536..60641) /locus_tag="ClothDRAFT_1887" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430026.1" /db_xref="GI:256005055" /translation="MKRIILAMFVICFSILCIGCNSREKNYNQKDELMEEDNQNIEDI FNENDTKSQTIAQFGFGFISENFSEREVYEYNGKEVCIPYYVEGMEEKVKADFGLMFF VDGIPQPYRIRRKNGTVTEEQFMHKFSLGYNEREEFDVVFTPVAGKKGDRIGVISATI LKPDFIPEDENRPVYGVYHSLAANKPSEIYFKSEFVNEKELRGYSKYVLEDIPEELKS NVGSEANAFDDIDTMTRTEIIYDDKSKNVIYAKNGKVKFKFRIYGGPEIEYNTTIFVN HKPVRIMNSDYLAAKIEKGKMCTFDLELDISDYERLNTIYAISNPSGKGYFADIYFPI KTNSILLVNDLKSSTQSQGNKNSAHKNYLDLSKSGTLAQDKDYSRYLDVDYESGYMLL MENGKSSPVKQITIEKNSFIEKALEFDKGYIIVTAYADRPVELTEESGFKFIDFPQDV KRRLVKIYDKNLNLQKEIDFVDIFPQKNNYHQTIVSKMTVSRDGKKIIWAESSPKLYM YDVETGKTSEILNETSNNICFSSVLFAGDDIVFYGIRVNEEGTFYYGAFEPQSKKMNV FAEKNFNCVRMRVSQKYVVFEEDRNPMKSSSGRLLGIDLQTKKNFKMQLDGEENNMAI ATNDGKYLIAIKSNSDGSHCIRQYKLKSDKIVHEEIVAPEMGIPIEIYTRDEPSTCII LFQKDNGEVISCKYNCKEE" sig_peptide complement(60573..60641) /locus_tag="ClothDRAFT_1887" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.930) with cleavage site probability 0.618 at residue 23" gene complement(60903..61325) /locus_tag="ClothDRAFT_1888" CDS complement(60903..61325) /locus_tag="ClothDRAFT_1888" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430027.1" /db_xref="GI:256005056" /translation="MKKVRVTALIICIIVTISMTGLLVNAGANEGSGQTPEFGTFSWS LGHEVTHPISRTYNVRVEGITSITKYSAGTTVIVKIEVQDNKTGTPLYTCIDSKTNAP TAKTLTKSNILPHHEFAAFGCHEARGKNAIVRYTCTTF" sig_peptide complement(61245..61325) /locus_tag="ClothDRAFT_1888" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.759 at residue 27" gene complement(61436..62032) /locus_tag="ClothDRAFT_1889" CDS complement(61436..62032) /locus_tag="ClothDRAFT_1889" /inference="protein motif:PFAM:PF02659" /note="PFAM: protein of unknown function DUF204; KEGG: msu:MS0192 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein of unknown function DUF204" /protein_id="ZP_05430028.1" /db_xref="GI:256005057" /db_xref="InterPro:IPR003810" /translation="MSSIELLIIAVGLSMDAFAVAICKGLSMKKMSYRNAVLTGCFFG GFQALMPLLGYLLGTQFKDYITSIDHWIAFGLLSLIGINMIKESKNTCEITDEDDTFS LKSLTVMAFATSIDALAIGVTFAFLQVNIIPAVTMIGITTFTFSFLGVKIGNLFGVKF QSKAEIVGGLILIGMGCKILFDHLGVISFVFDSLNKFN" misc_feature complement(61478..62032) /locus_tag="ClothDRAFT_1889" /note="Predicted membrane protein [Function unknown]; Region: COG1971" /db_xref="CDD:32154" misc_feature complement(61790..61996) /locus_tag="ClothDRAFT_1889" /note="Domain of unknown function DUF; Region: DUF204; pfam02659" /db_xref="CDD:145682" misc_feature complement(61505..61696) /locus_tag="ClothDRAFT_1889" /note="Domain of unknown function DUF; Region: DUF204; pfam02659" /db_xref="CDD:145682" gene 62312..63292 /locus_tag="ClothDRAFT_1890" CDS 62312..63292 /locus_tag="ClothDRAFT_1890" /inference="protein motif:TFAM:TIGR00706" /note="TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: peptidase S49; peptidase S14 ClpP; KEGG: geo:Geob_2906 signal peptide peptidase SppA, 36K type" /codon_start=1 /transl_table=11 /product="signal peptide peptidase SppA, 36K type" /protein_id="ZP_05430029.1" /db_xref="GI:256005058" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /translation="MNKKQLIGLIVAGVVFVFVCSSSVLVNTVSKRLGTSLNLSDSES SLPLTPYIGVVSVEGTIMDSNSTTSFLSNGYNHKETLKLIEDMKNSASNKGILLYVNS PGGGVYESDELYLKLKEYKEETGRPVWTYMSNQACSGGYYISMASDKVFSNRNAWTGS IGVIISLTNLKGLYDNLGIKGIYITSGRNKAMGAADLELTDEQRDILQSLVDEAYEQF VEIVAEGRKMTVEEVKRIADGRILSAKQALELNLIDEIATYDEVKEAFSAELGNVKIY TPKKKDPFGLSSLFSYINSLKPRSDTEIIAELIKAKGNGVPMYYAMPGQY" sig_peptide 62312..62392 /locus_tag="ClothDRAFT_1890" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.870 at residue 27" misc_feature 62462..63094 /locus_tag="ClothDRAFT_1890" /note="Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023" /db_xref="CDD:132934" misc_feature order(62483..62485,62606..62608,62723..62725,62768..62770, 62774..62776,62798..62809,62954..62956,63026..63034, 63038..63040,63047..63049) /locus_tag="ClothDRAFT_1890" /note="tandem repeat interface; other site" /db_xref="CDD:132934" misc_feature order(62543..62545,62564..62566,62642..62644,62843..62845, 62849..62863,62948..62950,62960..62962) /locus_tag="ClothDRAFT_1890" /note="oligomer interface; other site" /db_xref="CDD:132934" misc_feature 62723..62725 /locus_tag="ClothDRAFT_1890" /note="active site residues" /db_xref="CDD:132934" gene 63252..>64041 /locus_tag="ClothDRAFT_1891" CDS 63252..>64041 /locus_tag="ClothDRAFT_1891" /inference="protein motif:PFAM:PF06271" /note="PFAM: RDD domain containing protein; KEGG: pca:Pcar_2416 hypothetical protein" /codon_start=1 /transl_table=11 /product="RDD domain containing protein" /protein_id="ZP_05430030.1" /db_xref="GI:256005059" /db_xref="InterPro:IPR010432" /translation="MGCRCIMQCRDNTNIIYAGFGARLAAYLVDSLLVGIALLVVRIP MFIANIIGTPDFITAPILFQFNIFDIVIYLLSILYYTLMTYYSGSTLGKKFLNLKVIS ANGEKLTFINVLYRETIGKYLSGIAMFVGYFMIAVDEQKRGLHDILCDTRVIYNFKVP VKTAEKYPSKKYAWTWSIKEEFLKDFVELHLKPSPEMLEEQKKAGYKNSSFFNNGNQF FFVFECDNIDYANNYLSSSQVFREWYETVSPMVENPFDLKNAVAV" misc_feature 63300..63701 /locus_tag="ClothDRAFT_1891" /note="RDD family; Region: RDD; cl00746" /db_xref="CDD:153968" misc_feature 63756..64019 /locus_tag="ClothDRAFT_1891" /note="Domain of unknown function (DUF718); Region: DUF718; cl01281" /db_xref="CDD:154314" ORIGIN 1 tttgtccatt gcattatatt caaatgcata tcccgccccg ttttcgcctt tctccgcata 61 ctgcttcggc gctataacct ttgtcatgtt tcctgctttg tcatagcaga ttcttgttgt 121 gttcccttct gtatcggtta tgtgggttat ccggtcacat tcgttgtact tcattcttac 181 tgttccgtaa tctgtggttg tggccactac ccgccccact ttgtcaaatt catatttaaa 241 tatgttccct accgcatctt ttatcaatgt cggtttgttt acatcttctt ctccatactc 301 aaaggtcttc gtgttgtttt ccgcatcttt tgatgttgtc attcttccat attgatcata 361 ggtatacgcc cactccgaat aacttctgct tccggtcttt acaatgcgtt ttaaaaggtt 421 tcccctttcg tcatattcaa aagacacttc tcctccgcca ggcgacacta cctttatcag 481 tctgccttcc tcattatagc tgtattttgt tttgtagcag aaaggctccg gtgagattac 541 ttctattaaa ttgcccttgt catcatactt tttatatgtt gtgttgccat ttctgtcagt 601 ttcactgttt ctgttgagat tttcatcata ggtatacttt tgcacgcttc cgtcatcata 661 ccttatttca gtaagaagca tgtctgtatt gtatttatat acacgggtta tgccgctctt 721 tatccatttg aaggtgtttt cacgattttc ttcgtcatat tctataatca attcattgtt 781 ctcatggtca agctgcctta ctactctgcc cttttcatca taggtgtttt ggacataggt 841 gttgccgttc tggtcggtta ttgaaatcag tcctatgtta tcgtacgcat aggtaatctt 901 ccctccgtca gggtatacta cctgtgtcag atttcctttt tcatcatatt tatatttcaa 961 attccttccc gtatggtcgg ttatactgac aatcctgcca ccttcatagg aaaacatcaa 1021 aagttttcct cccggtgaca ttactgaaga cagcaatccc tcccggttgt atttaaactg 1081 tatctcattg ctgttcgaat cggaaattga tataaggttt cctgcctggt catatttgta 1141 agtaattcct ttttgaactt ttaatatgta tgtaccgtcc tctgttttta aaagagtgtc 1201 atatactccc tttggagatt tgaaactccc tgtatcggta tactcaaata ctcttatatt 1261 cccatccgga tatgccacta ttatgtcttc actgtcttcc tttttcttca ggcacgtttc 1321 ataatctatt ttccagcctt tgccgaatat tccttccgta ttatccattg agttataata 1381 tctggttatt tcaagagcca tacctcttga aggtatggtt atatctctcc tttttaaata 1441 aaaatttccc gacaccacgt ttacagggtc tccggcaaac gtgttcggac agtttgcagt 1501 tcccgggcct atcaaccggt tccataacga ataacccgct actatggctg atgcaatacc 1561 gttaccagtc agtattgctg aagcaattct gcttataaaa tctgcagttt tcatctttct 1621 tgccgcagcc gatgctttat tgtcagcctc tatcatttgg tcccttgcct ctataaggtc 1681 ctgtgacatt tcttttaatc cggttgctat atttattgca gctgcacgag ccaacgacgc 1741 tttttgatct actccctctc tgcttctaag ttcccagtca atagaactta ttatcctttt 1801 tatatcctgt gccatatcat caaacttgtc tgataattgc cttattctct cagctaccct 1861 tgtcatctct tcgggagtta tttttatctg catatctacc tttgcccccc tcttgcaaaa 1921 cgaatatgat gtcatttatg aaaattatac cattagttac ttttgaattc aataaagctt 1981 ttcgctttgt ctctttctgt catccaactt tctcctcaga atttgctctg atgtcttaaa 2041 aaggtttgtc tccttttctg tatatatata gggtaattgt tgaacctctg atcggccatg 2101 acttaggcat gtacatatac tgatctgctt ttttgtcata aaagtatctt gcctcaataa 2161 catccgtatc ttttactttt gaccttacaa cactcattat ttcttttact gtctcttcac 2221 taaatttttg taacaatatt ttctccatat catctttctg cttttcaaca tcctttttta 2281 aaaaacctat tgtgaacacc acctcatagc tagtatcatc ttttgaagcg gcaaccatta 2341 aatccgtatc ctttggtaca ataaacccgg ctacttccct tgtatcgtcc tcatcttcaa 2401 ctttatctgt cttgtttgca tctatgtaca cagttttaat ctcatccttc cacctgacag 2461 ttgcaccaaa tgcctccgcc acatagcggg ccggtacaaa tgtccttcca tttatcaata 2521 atgcttccgt atccatttgc ttcttttgac cgtttaactg atattctctc tccccaataa 2581 acaactccaa tgtcgttcca tccattttaa atactgcttt cttagcattt gcatcccaag 2641 ttactgtagc tcccaaagct tctccaataa accttgccgg tgtctgcgtc cttccatttg 2701 catcgatgaa cggcttttcg tccggaaaat acagctcttc tccatttaca agcacacgca 2761 gcggtatatt aatcgcaaaa gtgatatttg aaaaaagtat agttaaagca aatactgtca 2821 acattgatgt tgtcaacctc ttcatcataa cccctacctt ttttcggttt ttaccaacat 2881 aaaaactgct ttacttaata aaacagttct attcctcttt atccttttct ttaaaaaaat 2941 acttaatttc atcagcaaaa ctatacacaa aaaattgata tttcacatgt aaacaaactt 3001 agtaataaac attatagtat aaaataacaa atatgccaat ataatttcaa acaaattaaa 3061 aaggactgcg actttaagtc acagtccctt aaaacccgac agtacagttt agctgaaaaa 3121 ctcatcatac aaagccttta ccgccttgac attatcttca gcctttacac caaacatcat 3181 gcttacttcc gatgaaccct gatttatcat ctctatgttt acatttgctt ttgccaaagc 3241 agtacaagct cttgcagcaa ttcccaccgt gctcatcatg ccttctccta caatcataac 3301 cagcgcacgg tcatattcta tctttatgtc atcaacattc aattcatcct ttatccttct 3361 taccactctc tcttccttag ctttgtcgag ctgcttttgc tcaattataa tggacatgtt 3421 gtcaatccct gaaggaatat gctcatagga cagcccttca tcttccaaaa tactaagcac 3481 ctttcttcca aaaccaattt ccctgttcat catgtacttg cttatataaa tgcagcagaa 3541 tccggtaccg cttgctatgc cgataacagg gccgttgtcc agtttccttt tcggcacaat 3601 tgtagttccg ggagcagacg gattgttggt gtttttaata catacaggaa tttccattct 3661 gtaaaccggt tcaagagttt cctcatgcag cactgaaaaa cctgaataag aaagctccct 3721 catttccctg tatgtaaaag tcgcaatcgg tttcgggttt tcgataatgt tgggatttgc 3781 ggcaaaaacc gagtcaacgt cggtaaagtt ttcatacaca tcagctttta ccgcagctgc 3841 aagtatggct cccgttatgt cggaacctcc cctcgggaat gtaacaacat cccccttctt 3901 tgaatatccg aaaaagccgg ggaaaatcat tattttatcc ctttcacgca ggcgtttcaa 3961 attctcatat gattccggca gcacccttgc atttccgtat tcctcactaa gcaaaagtcc 4021 cgcatctttt ggatttacat actcggcatc aattcccctg cttaccagat aagctgcaac 4081 cacttttgca ttgttatcct ctccggcagc ctttatggtg tccataaact tatccttgtt 4141 gccgttattg cattcaagcc tttttttcaa atcatctgca accatttgtg taatatcggg 4201 cgaaagctca aggcctttta caatatcatc aaatctatca ataacagcct gaagttcggc 4261 atccgctttt ccttccttat aatatttttc tcctaaagca attaaaaggt ccgtaacctt 4321 tgtatcttcc ttacagcgtt tacccggagc ggaaacgaca atcagctttc tgtccttgtc 4381 acttaaaata atatcacaaa cttttcttat ttgattcgca tccgccagtg acgaacctcc 4441 aaattttgca actttcataa ttaaaacctc caaattcaga tttatacaac aactatggca 4501 aaaacacata aaataattgt tcctaataca ttataattat ctgactttgc ttatgttaat 4561 atgcagcaaa aacaaattga acctaagatt agtccaggac tcttatggca tttaccacat 4621 cttttacagc tttgctgcct ttaagttgtt gaagagaatt gcaatagtct ttctccaaaa 4681 cgcaggaagt aacaaatgcc aattcatcct gtacacttgc atcatacgct tttacccatt 4741 caacatttcc aaaagcattc tccaccgctt ttttagcttc agcttcattc tccactttca 4801 gtctcacaaa ataccttgtc ctggtttctt tcaaatcaat gacgttgccg ccgtctttta 4861 caacccagtt atagctgccg caggtacccc aatgcttcac aatttcaatt acatccgcca 4921 caacggcgct tgccgtgggg agcttgcccg ctcccgggcc gtaaaacatc acttctccaa 4981 ttgcatctcc tctcacaaca atagcattaa aaacatcttc aacactgtaa agcggacttt 5041 tgctgcttac tatcgcagga gcaacccttg ccataatacc gtcaccgatt ttttcgctta 5101 tggcgacaag cttgatggtt gaatccatgc tttcggcata tttcatatcc gcaaggctta 5161 ttttttttat gccttccgta tgtatctttt tgtaatcaac aaattcattg tacgcaatgg 5221 atgagagtat tgcaattttt ctgcatgcat catgcccttc tatgtccgcg gttggatccg 5281 cttccgcata tcctttctgc tgtgcctctt tcaaagcctc gtcaaaatct tttccctgcc 5341 ttttcatctg tgttaatatg tagttcgtag ttccgttgag tattcctatg atgctgtgta 5401 tttcatttgc ggcaaggcag cggttcaaag gcctgataat gggaattcca ccgccgacac 5461 ttgcttcaaa cagatagttt actccatttt cctttgcaag cttcaaaagt tcaggtccat 5521 gggttgcaac cagctccttg ttcgaggtta caacattctt tcctttgctc aaagccttct 5581 ttgtaaattc gtacgcagca cctattccgc ctatggtctc aacaactatt cctattgacg 5641 ggtcatcaaa aatttcatca ggattctttg taaacaaatc ccgttcagga ctgtccggaa 5701 aatccctgat atccagtatt ttttttacgc gaatctcctg acccgctttc tttgatatgc 5761 tgacactgtt ttttcttata acttcaacaa ctccggagcc gaccactccg tatcccatca 5821 ctgctatatt aaccataaaa ccccctctat tctcttgcaa gtatctcttg tctttttaca 5881 ccttctatgc tgcttatgtc atccagcaaa tcctttatat cccttgtcat ctggccagtc 5941 tcaattgtaa tggtgacatc cgccaaaccg tttataggta tgttttgatt aatcgttata 6001 atgtttgctt ttgaatcggc aattctgttt ataatgctcg acagaatccc ggcataatct 6061 tccacagtaa aaaaagagtt attacctttc cctgtgaagt ttcataaaaa ggaaatatat 6121 ggtctttgta cttataatag gcacttctgc tgatacctac tttacggaca gcttcattta 6181 catttttaat tgctccgctg gccaatattc tctttgcttc aacaaccttt atgaaaacct 6241 ttggcaaaac cgaagcatcc accaaataat attttgatgt atttctcata ctccctccgt 6301 gtccacgtac cgtgaacaag tgtatttata ctgtgtaata gtatcataat caaaaagtaa 6361 attcaagagg tttgttaaaa atttaataaa caaaaaaaca ctctatcatc agagtgtttt 6421 ctaactttaa tattaatact ccaaatgatt ttttcaaccc tttgttcacc aaatacagct 6481 ctcttttgtt ttaaaagtgt actcaatctc tttctgcatg gtgtcgtagt cttccaaaag 6541 caccaaaaac cttttcacca cttccgcatc aaactgggtt cctgagtttg ttatcatttg 6601 atttttcgcc tcttccaaac acagcttcga cctgtactgc ctgtcggaag tcatcgcgtc 6661 aaaggcatca gccacggata tgattctcgc aaggaaaggt atctcatcac ccttaagtcc 6721 gaatgggtag cctcgtccgt ctatcctttc atgatggtac tttaccaaag gaacaatatc 6781 tttgaacatg gaaactgccg ataatatatg tgctcctttt ataggatgct ttttaatctc 6841 ttcatattcg ctttcagtca gcttgtcggt tttaaacaaa atgtcatcgg caatgcctat 6901 tttccctatg tcgtggaaaa tacctgccgt tttgagcttt tccagcgact cttcgtccag 6961 attaaagctt ttgcctattt ttaccgcata atacgctacc ctgtccgaat gtccccttgt 7021 atatacatct tttgcgtcaa ctgtaagacg caaaacctgt atggcatcca gatacctttg 7081 tttcaactca ttgtatgttc tgtcaagctc atcatttttg atactgacta tggaatgaag 7141 gtatatattg cttatcgacg ttgccgcctg agttatatat atcttaagca gttccatttc 7201 aacaggaata tgagtggtct caaggtaaat aactcccaaa gtctggatag tgtcactcat 7261 aagaggaaga ataattcctt tttcaacata agcaatctgt tttaaagtcc tggtacgtcc 7321 catttcctcc aaaaaagccg gttccagcat gtctataaac ttgtccggac tcacgtcata 7381 aattcccatt cctttaaaca aactttcatt tttgtcgtcc cctatgagat tgtcaataat 7441 aataaatgca tctttacaat taacaaaggc cataatatgg cgaagaattt cttcaagcag 7501 ttcctcaatc gatttaagcc ggtatatatc cggcacggta agaagaattt tattcaaacc 7561 gtccctaaaa tttctgattg ttcttttctg atagatggat ttgactgcag actctattaa 7621 aagtatcaat tggtcaaaat tgtccgcttt ctcacaatat ccttgaatat caagagattt 7681 tattgcctta agcggaggtg ctgcatcttt gtaaccggtt aagagcagaa tatatatgtc 7741 tttattaaat ttcctaatct cttcgaccac tttgtctccc aatataggct gcatcaaaaa 7801 atccagtatc ataaggtcaa attcttcttc ccggaccctt tcaatcgctt caagagggtt 7861 gttcactccc gtatactgat aacccaaacg ctttattatt accgacaacg aatccagtat 7921 tcctttttca tcatcaacaa caattatttt aatgtccgag gacttcccct gcctgttttt 7981 tctcacctta taccctccct taaaggccaa atccaaagct acgagaactc tatcatgaag 8041 taaaaccaaa taatccaaat tcaacgcgat tatataattt acataatatt acaactatat 8101 aaattgcgga aatttgcatt atttaatatg tatatcgact tttttgcagg atttataaag 8161 aataatataa acacacctct tgaataaatg aagcctatag ccgaaacaat ataatcaagg 8221 tgccagggca ctgaagtaaa aagcaaatca aaaatgaacg aggaaaacta cacggaggaa 8281 gatggcaaat gaaaaaaatt cgtcttgctg taataggtac gggaatggcc tgggaaagac 8341 ttcattatcc tgccattaaa gaacttgaag acaaatatga aatagttgcg ttgtgcaatc 8401 ggacccgcaa ggatgccgaa gaatttgcga aaaaaataaa cttaagcatg gacagggttt 8461 acgatgatta caatgaaatg ctcaaaagac aggatataga tgcagtagat atccttgtgc 8521 ctattgaatc caactatacg gtttcggaag ccgttgcaaa agccggcaag gactttattt 8581 gtgaaaaacc tcttgctgca aacagggaag aggcaaaaaa atatctggaa ctttcaaaaa 8641 aatacaatgt aagaatcatg atagccgaaa actacagata cagcgacgag tacaacaaaa 8701 tcagggatat agtaaacagc ggaaaaatcg gggatgtggt atactttata aaaaacaaca 8761 tatcctgctt cccctgtgaa atgacaaaag ataccttcgc cgccaccgaa tggagacagc 8821 atcccaaatt ctacggaggt gcttttttgg acgcagcagt gcatgatatt gcggcaatga 8881 ggcatatttt cggtgcggtt gaatgtgtac aggcttttgg aaaaccacag gcagaagatt 8941 tcaatccgta tgtgtcagta aacgctcata ttctctttaa aaacggagtc atagggtatt 9001 atacgtacta tacttcgggc attgaaactc aaaagccggc ggtaggcttt agaatcttcg 9061 gcaccaaagg cgaaatatat cttgaagaca agacatgcgg aataataaac gtgtcatatc 9121 atgacggtac ttcggaactt gtaaacttta ttcccgaacg gggcttttac aacgaacttt 9181 taaattacta caacgccata aacggtacgg aacaaatatc tgtaacccct gagatggaat 9241 atggggatgt caaaatggtt tttgacattt tggactctgt atccttccgg gaaatcatat 9301 atgtggatga agaagaacca aaaaggcggc tggaaattgc cgatgatgaa gcaaaaatac 9361 atcctttcct tcagtaaatt taaaatggaa tgaatttaaa acgggcgcat ttttccgtct 9421 gtaaatgcgc ccgtatattt ttatccttca ctctatgtat gcattgcatt gcctaagacc 9481 gttttccaca tcctttcggc tgaaaggctt tggaatgtaa gccactgcgc cgtttttcat 9541 agcctgttgt ataacttttt cagatgtcac cgctgatacc attattattt tactgtcgca 9601 gctcacctgt aaaatcttct tgattgcctc aagcccgtcc ataccgggca ttgaaacatc 9661 aagagttaca acctcgggct gtatttccct ggctttgtca acggcttcat aaccatcctg 9721 ggcaaataca atattgctgt atccaatatc tttcagagta ttgcccaaaa gtttcctcat 9781 aaagagggca tcatcaacaa ccagtatttt tgtcttatcc atcctgcaca acccctctgt 9841 ttctatttaa gataatatat atgtttatat atttatttaa aaacaacttt tttcattctg 9901 aatattaatt ttatgaaaat gaagacataa ttgactgaaa ttttagaaac aaattgtgaa 9961 atcaaatgac gaaatgccgt actacgaata ccttacgata caagtgcaat ttaagattgg 10021 acccgggttt cactttttta agtgaaaccc gaaatttaat cagttttaca gaccaagaat 10081 actttcaacc tgctgtttca tatcaaattt actgcaaacc tgtttgtgaa gcacaggctt 10141 tttgtcaaga tctttcaaac cttccggtat tttaagcctg cactcttttg ccaaaacctc 10201 aagaagttca aattccgtcc ttccttttaa cgcttcattt cccaaaactg cttttaccac 10261 actttcatta aatttgaaag gacttgccgt tgacgcaatg accgtctttg tcacgtcacc 10321 ggtggaaatt acatatttgt catacacatc aacacctaca gcagtatggg tatcaatgac 10381 atatccgtat tccttgtata tagcctctat cgtctttaaa gtttcagcct cgtttgaata 10441 tccgccccag aatatttccg atatcttttt cttcattgta ttgtcaacag tatattttcc 10501 ggtttctttc aaactgctca tccaattgtt caccggcaaa ggatcatgtc cggtaagttc 10561 aaagaggagt ctttcaaggt tgcttgaaat caatatgtcc atagacggcg aaatggtcct 10621 cttaaactcc ctgtttttgt catatactcc tgtattgata aaatcggtta aaacattatt 10681 gtcattggac gcacaaatga gcctgtttac aggaagcccc atttgcattg catagaaagc 10741 cgcaagaata tttccgaaat ttcctgtggg gacaacaaag ttaatcttgt ctccctcttt 10801 tatttcaccg ttcttcagca tatcagcata tgccgaaaaa taatagacta tctgaggtac 10861 aagtctcccc cagttaatgg aattcgccga tgaaaatttg aaattgcctt tgtccatttt 10921 ctgcttaagt tcttcatcgg taaaaattgc ttttactccg ctttgtgcgt cgtcaaaatt 10981 tccttccact cctatggtgt aaacattttt tccttcctgg gtgaccattt gcattttctg 11041 aacctggctt acgccatcct ggggatagaa cacaattatt cttgtgccct caacatcctt 11101 aaaaccttcc aaagcagctt ttccggtatc tcctgaagtt gcaaccaaaa ttacgatttc 11161 accggtttcg ccggtttttc tcactgcctt tacaaggaaa tgaggcaata tttgaagtgc 11221 catgtctttg aatgcacatg ttggtccgtg ccacaattcc aggatattga cattttcatt 11281 cagctgaacc aagggagcaa ttcttttgtc gtcgaacttt tcatcggtat aggcattgta 11341 aacacagtcc gctatttctt catcgctata atccgtaaga tagtgcttta atatatataa 11401 cgccctttcc tgataactca tatcagccat ggcgctaatt tcactaccgg taaaacttac 11461 tttattctcc gggacaaaca atccaccgtc cggcgctata ccccttttta tagcttcagc 11521 agatgataca gattttaatc cccctcgtgt actttcataa tacatttcgt ttcctcccat 11581 atatcgtaaa tcgcatatgt tccaaattgc aaaatgcaat tctatcattg tagttacaaa 11641 ttcacgtacg tttggaagta caatgcaaat gacaatcaaa tcgacaacgt ttttacaaac 11701 tacaggacat aatgcacaaa aattcagttc aacagattgt tcaccaatca ttcatcaatt 11761 ttaataatat aataaatttc aaaaaaaata aagaatattt tgtataaatc tataaattat 11821 aagcaattgt acaaacccaa aattcttctt aaaatataaa aagcagcata tctttggata 11881 tattttctcc ggtaaacttt tcttaaggtg caaagcgcag ctattcttcc cgaatcaatc 11941 agaaattttt tgtccttctc gctcagttca aaatccagaa aagaaatatc cccggtatat 12001 attcttacaa gataactatt cttgtaatgc tttatgttcg ggatgccgaa atcatgcacg 12061 gcggatacaa ggcctttcag gatgttaaga ggcgtcataa tactaaacag tttatccctt 12121 ccctttagct cgcagacaat aagcggaatt gccattgaag gttgaataag ccatacgggc 12181 aaattatcca atacaccgcc gtcaaccagg taatgcttct ttacactgcc tccgtccttt 12241 ttcaagactt ccactggctt aaaagcaaaa ggaacactgg tactcatcct cactgctttt 12301 gcaacctcaa gccgatccgg atcaatgccg taataggaaa tatcgtccgg aagaaccact 12361 attcttccgc gatttgcatc aacagccgtc attctgactt tgtatccatt tggatttgtc 12421 cggtctgttc tgccccctct taaatccgca aaggtcttta taccttttct ttttaaagtt 12481 ttatacaccc attcttcaag atagtctccg tcaaaaaggc atccttcttt actgtaagtt 12541 acaatattct tcagaaggtt tcttctgtat ccggtaaact cctcatccac ttcaacaaac 12601 tcgccattgt tttcagaact gtaatgtttt ccccggtcca taacaggcat attcagaaaa 12661 tctttaaaac ttttattccc ccgaaatgca ctgcttaagc tatattccat atattttttt 12721 accaccggta tttcccggga aatatccgaa agtttcattt tattaaaatc aaactcgtcc 12781 aaaattcttt ttaattcaca ggaattgtat ccggcaccta taaaagcccc taccagagca 12841 cctgccgaca ctcctgctat atttttaaaa tagaatcctc tttcctctgc cacttcaagc 12901 attcctatat atgcaattcc taatactcct ccgcctccca acacgagatt tgcaagcttt 12961 atgtctctgt ccatgccgga tttgcctttc acaggattgt aactatgtta tatatattat 13021 ttaaaatcaa caaatattaa tattaaatcg gacttttccg cctcattgct ggctgcctcg 13081 tatatagttt atacgttccc ttgagtatcc ggcataggaa gtgttcggat atttatttac 13141 aacctcttca aatatctcca aagccttggt ggtgttgttg agttcctgat agcatactcc 13201 cagataatag agattattta ccgcatacct ccaattgtca ctgtaagagc gggatctttc 13261 aaatctctcc acggcttcct ggtaattttt tctgttgtac aattctcttc ctttattata 13321 ttcttcctgc gcagctttag gcatgacatc ctgggataat ttgtcaaact tttctttttc 13381 cactccggta aatgcggtgt ttttcaataa caataataaa tcggccgctt cacgatactg 13441 gttctgggaa gcatatttct caatttgaag aagttttgaa gcattcaaat aatagtcaac 13501 ctgctttttc acttcttcaa acgtgtcgtt taatccctga tatttctcgt tcagttcatc 13561 atactttttc tgaatctcat ttttttctcc aataagagtg ttattttcct ctgttaactg 13621 ctccaattgc tcattattct cttctctgaa ataataatta taacttaaga ggaaaaccag 13681 aagagcacca attacaaatc ccaaaaacag tcttgccgtg tccatgggct tgtattccca 13741 tatttttatc agcttcttaa aggaaaaaga ggcactgctt tttaccgtca cctggtttga 13801 aagctgagct gcccctctgt ttctttcttt cttcttcctg gattttttat ccttttcctg 13861 tttatttccg acaggatcat acccggaatc aatttctttt aaatatctca tcgccattac 13921 gctgtttttt tccgcatcca caactttttg gaaaacttct gcagctttat cgttctctcc 13981 tatatacata tagaagatac ctaacaaatt cattgcctca tgaaaatccg gattcaggga 14041 aatggctttt ttaagctcaa ttatggctat atcctcgctt tttgcgcgaa aatcctccaa 14101 agctttattg taaagcacaa ttgaattttt tatattgtca ggtatgttcg ggttcgcctg 14161 ggacaactta tccaaatcaa tcattggata attttgaagc tcatttttaa aatctatcat 14221 agaattaacc cccgcctcat tattatacct tgattatacc ttgtaagcaa acaactttgc 14281 acaaaactcc ttaaatactg ctttccaaat tcattactta caattcattt atcatttatg 14341 attcatcagc acacttcgta tctcaccaat ataatacagc gaaccaaagg cacaaatcac 14401 tccgtccttt ggagcaatct taagactttt ttccaccgca tttacaattg tatcacttat 14461 tgatacattt ttacaatagt tttcgagatt ctgcgccagt gtctcagccg gcaaagctct 14521 gtcgctgttt ggtgtcacag taattatatc ctccgcaagg ggtgcacata cctcaatcat 14581 tgacttaaaa tctttatctt ttaaaacacc tataataaat actatttttt tgccgggaaa 14641 atatgttttt aaaaactcgg aaagagtttt tgcaccttca gcattgtgag caccgtctat 14701 caaaaatatc ggttcttttt taagaatttc aagtcttccg ggccattttg catcagccag 14761 tccttttctt acagaacttt cgcaaattct gtcataaccc ttacgtgcca aaatcaaagc 14821 cgtttcaaga gccaccaccg cattttttac ctgatgctct cccaaaagtc ctatttttaa 14881 agatttaaac tcgccataat caaattcctg cccgtctggt gaaaattttt ttatgttaat 14941 ggaatgaaaa gacaatttgt gaagtcgggc acctttttca tgacatacct cttcaaaaac 15001 cttgtctgct tcccgggtct ggggatacaa caccacatcg gtgcctctct ttatgattcc 15061 cgccttttca aaagctattt tatccaaagt gtctcccagc tgtgccatat ggtcgtaact 15121 tatagtggtt ataaccgcag ccaaagggga atctatcaca ttggtggaat caaacctgcc 15181 tccaagtccc acctccagca caacaatgtc gcaatccttt tcataaaaat attgaaaagc 15241 gattgccgtt actatttcaa attccgtagg atgattttct ccctgtgaaa tcatcagttc 15301 aacttttcct tttacatact cggtaattct tgctaaatct tcttttgaaa tttcatcatt 15361 gttgatttta attctttcgg taaaacgttc aatgtacggc gaggtgtata taccaacttt 15421 gtagccggat tctttcagta tactgcttat aaacgcaacc gttgagcctt ttccgttcgt 15481 tccggcaaca tgtacgtatt tcagtttcct gtggggattg tccatgaatt caagaagttt 15541 tcgaatattg tcaaggccaa gctttattcc gaatttatgg gtaccgtgta tatattccaa 15601 cgcctgttca taattcacaa cttatacctc ccccgaccaa gctttgcaaa aatggggtta 15661 tgcctttttt gcaaaccccc tttttgcttt gcttctcata aataaactaa aacttattca 15721 tcaattccgc aacatttttt atatttcttg ccgctgccgc acgggcaaag ttcatttcgt 15781 cccaccttgt ttctttttac cacaggtttt ctgacttctt ctccgtggga ggcagtaacc 15841 ggttcagcca ctttttggcg ctgtggcata cggttgcggt caatatgtgt attgagtatt 15901 atccttacta catctgactg gatatttctg ttcatttctt caaacatttc aaagctttca 15961 aacttgtact ctataacagg gtccttgtgt ccgtaagctc taagccttac accatgctgc 16021 agctgatcca tgtcgtcgat atgatccatc catttttggt ccacaactct taaaagaaca 16081 actctctcca gctccctcat aagctcggaa ccaaattctt tttccttttc ctcatatctt 16141 ttgagcatgc tgtcaagtat tatttgtctg agcttttctt tgttaagatc ctccatctgc 16201 tctttggaaa aatccagggt tccttccgga acataagcct tttcagtata agaccttatg 16261 ccttcccagt cccagaaatc cgggtgcgga ttttcactgc agaacagatt tacaatatag 16321 tccgcaatgt tctccatcat ttttacgatg ttttctttga gattctcgcc atttaacacc 16381 tttcttcttt gagcgtagat aacttctctt tgcttgttca taacatcatc gtattcaagg 16441 acgctttttc ttatggcaaa gttcctgctc tccactctct tttgggcatt ttcaatggcg 16501 tttgacagca tcttatgctc aataggctgg tcttcttcaa ggcccagtgc ctcaaccatt 16561 cccatgagtc tgtccgaacc gaaaagacgc ataagatcat cttccaggga tatataaaat 16621 cttgactctc ccgggtctcc ctgacgtccc gcacgtcctc tgagctgatt gtctatacgt 16681 ctcgactcgt gtctttcagt acctatgata aacagtcctc cggctgcaac aaccttttcc 16741 ctctcagcat cggtaatttt tttgaatccc tcataaagct cgcggtacac ttttctcgct 16801 tcaagaatct ccggatcatt ggtatcattg aatcccgtgg cttgattgat aacatcttcc 16861 ctgaagcctc tttttctcat ttcctgcttg gccataaatt cagggtttcc gcccaaaaga 16921 atatccgtac cgcgacctgc catgttggtt gcaatggtga cggcgccaag ttttccggcc 16981 tgggcaatta tttcggcttc tttttcatgg tatttggcat ttaacacttg atgcggaata 17041 ccgtgtcttt taagcattga actcaaaagc tccgattttt caatagatat ggtgcctatc 17101 aatacaggct ggcctttttt gtggcactca atcacctgat ttataacagc attaaacttg 17161 cctctttcat tcttgtacac gctgtcggga tggtccaccc tgattaccgg catgtttgta 17221 ggtattacaa caacatccag gttgtagatg ctcctgaatt cctgttcctc ggtctgggcc 17281 gtacctgtca taccggacaa tttcctgtac attctgaaat aattctggaa tgtaatgctc 17341 gccaaggttt tgctttctct ttcaaccttt accccttctt ttgcctctat agcctgatga 17401 aggccgttgc tgtaccttct tccgtacata agacggccgg tgaactcatc cacaataatt 17461 acctgatcat cttttaccac ataatccctg tccctcttca taagtccgtg ggctctcagc 17521 gcctggttta tatggtggga tatggtcata ttgtccggat ccgaaaggtt ttgaataccg 17581 aaaaactctt ccgccttttt cactccgctg gccgtcaaag ttgctgtatt tgccttttca 17641 tccacaatat aatcggcctc aatgtcatcg gtttgctctt tgtcgtcaag ttcggtaaat 17701 acttttactt taagtcttct tacaaaagca tcagctctag tgtaaagatc cgtggattta 17761 tccccgacac cggaaataat aagcggtgtc ctggcctcat ctataagaat actgtcaacc 17821 tcatccacga tggcaaagtg aaggtccctt tgaaccatgt cctctttgta aataaccatg 17881 ttatccctaa ggtaatcaaa accaaactca ttgttggttc cataagttat atcacagctg 17941 taggctttct ttctctcttc attggtaagc ccgtgaacaa taagtcccac gctcagtcca 18001 agaaaattat acaatttccc catccattca ctgtcgcggg ttgccagata gtcatttacg 18061 gtaacaacat ggaccccttt gccttcaaga gcattcagat acaccggcaa agttgcaacc 18121 agggtcttac cttcaccagt tttcatttcc gctattcttc cctggtgaag gacaactcct 18181 ccaataagct gaactctgaa atgcctcatt cccaaaactc tccttgaagc ttcccttacc 18241 acagcaaaag cttccggaag aagatcatcc aaagtttctc cctggctgag cctcctctta 18301 aactcaggtg tcttggcttt gagctgttca tcgctcaatg cctgcatttc cggttccaaa 18361 gcctctattc tgtcaataat gggtttaatc ctcttaacct ctctatcact ataacttcca 18421 aatatttttt cgaatacttt aagcatataa aaacctccag atatattatt ttacattttc 18481 cttttttaat gcttttaatg ccgtcatggg atgtgtaaac aactcaaaga cgaatacaaa 18541 caatcccaat gccacaacca aatctccaat acttaccaca cccattccct gtccgataaa 18601 accgggcaaa tgtataatat cagctaaaaa tttaagcttt gtggtgctgc ttataacagc 18661 atgcttgttg tcagcgccgg acattatcat ctccgttact tctttgattc cggccttttg 18721 cattgcctca aggcttaccg gcatccttcc tccgtttaca agcatcacca gagcattcag 18781 tgaagcccca agtccgacaa accacaaacc gatatattct ctgttgaacc aaaagcagaa 18841 aagtaataaa acaaatacta cagcctgaat taaaaagctg aattttacgg cactttcaac 18901 ccctctgatt cctaaaatcc ttgtaacggt ctgaaggaca aaagcgacta tagccagcca 18961 catcttgcga agcctgatac cggaaaaatc acagggtttt cctttcatcc cttggactgc 19021 cagcgccaaa acaaaggcaa taagcatgac ggtcagataa agcaagctac cacctcaccc 19081 agcaaacact attaaaatgt ttccttcaaa attgcaggaa aatgcccgta tcaaatgaca 19141 ggatttctaa atacaaggag gagacaaatc cgacatatac agacttatat cccggcttgc 19201 ataaaaaaga gacccgtttt ccccaatcca ttgtacgggg aacttataca aaaaggcatt 19261 ataattgtat ttattgttaa aaagtttaaa gccgcagctt cttttatcat cgtcttttga 19321 cttctcagca caaattatgc agtaagcatc cgcggaaagc aactcgctat cctcagcatt 19381 ttcacaaaca gcttctttga acaaattgcc atccaataca acaagatccg gttctaaacc 19441 gtcgtatcga taaagatcaa tcaagtaacc ggctatattt acagttccgt ccgaagtcaa 19501 cgtcgacaaa atcagcaagc tgataaaaag ccttctgaac atttttacct tcctttaaat 19561 ttactctgtt tatctaaatt tactctgttt atcacacctt taagagttcc gtttatcgta 19621 acttaagagt gtcttatttt ttgttgtaca tcctgtcaag aatcttttta taaccatcag 19681 caccgtaatt taaagcgcgg tttattctgc ttattgttgc ggtacttgcc ccggttctct 19741 cacttatttc agtatacgtt ttgccctctc tcagcatcct tgcaacttca agcctctggg 19801 ccatggcctt tatttccgaa atagtgcata tatcctcaaa aaaatcataa cactcctcta 19861 tattgtcaag gagaaggatg gcctcaaaaa gcttatccgt caattcatcc ctgatttttg 19921 agttcataac cgtctcaact cccattaaat actaaagcaa aacaatccct ttgaaattac 19981 aatatcagct ttttcaaaaa cagtcaagaa cctaggtaaa acgttaacat tttgtttttt 20041 atattttttt aatataaatt taataatttt gtaacacaaa tgaaaaaaac tatagaattt 20101 agtcgttaca tgtgctataa tgaagatgag attctttata ctcttatttc ctcataatat 20161 aaatgaggtt tttttttgca gggtcttttt gttctgccat aagtacgctc ctttgtcaga 20221 ctgttctttg caacatcttg ctgttccaca atcatgtaca gcataatgat aaaaattata 20281 attataatgc ttggtactat aattttgcga ctttttttcg atattcaaag caaacttttt 20341 cttaccgggt taatacattt gattaatatt gtatccaatc gtatcctttt aggacccaaa 20401 aaatcaacta tctgtgacgt ttcctaaatt tacataactc agtttgatgc tttttgataa 20461 atattttgtc gaattttgtg atattcacac gttatctttc atattttatt aatttgatgt 20521 atattgaata tagtaatttt actaaaagtt actcccctaa aacccgttgc attctccctt 20581 ctctcattgg aatgcacggg gtcttttttt atttaccgga gaaaataact cagtataaaa 20641 gttcttagtc aactgttttt gtttatgttt tctgtaaaaa tatttatgta tttttcaatg 20701 tccaaaatta ataataagat gagtaatgaa aaaaatcctc gcaaaatata aaatatataa 20761 tataattatc aaaataatta ccaaacaatt atcgcataca agttttttac atggggagaa 20821 aagcaatgaa aggcaaaata gaaatcaata tgcccaaaga tgtgtcatat attatcgata 20881 ctcttaacaa tagaggtttt aaagcttata tagtgggagg ctgcatacgg gatgccattt 20941 taggaaaagt tcctgccgac tgggatgtcg ccaccgatgc acagcctgaa gacgtaaagc 21001 tcatctttga caaaatcgtt gagaccggaa ttaaacatgg aacggttact gccgttataa 21061 acggctgtaa ttatgaaatt accactttca gagcaccgtc gtcagctaaa attcccacta 21121 tcaaggatga tttggggtta agggatttta caataaacgc aatggcctac catcctgaag 21181 aaggtataat tgatccattt ttgggcatgc aggacatgga aaagtccgtc atccgcgcag 21241 taggctcccc cgaagaccgc tttcatgaag atcctttaag aatgctgaga gctgttcgtt 21301 taagctccac tttagggttt gaaatcgaca ggtcggtcct ttcggccata aaagaaaact 21361 gcaaactgat agaaaaagta agtccggaaa gaatccggga tgagctgtca aaaatattga 21421 tttcggacag gccaaaaaat tttcttgtct tgagagaaac aggccttctg aaatatgtgc 21481 ttccggagtt tgacatatgt tttgataccg gccagaacca tccttatcat gtttacaatg 21541 tcggaatgca tactttggaa actgtgtcga atattgaaag caaccttgtc ctgagatgga 21601 ccatgctctt gcacgatata ggaaaaccag ttgtcaaaac cactgatcaa aacggaacag 21661 atcattttta cggtcatcct gaagaaagcg ttaatatcgc ggataaaatt atgaaaaggc 21721 tcaggtttga caacaaaacc acaaacaaag tgctaaggct tattaagcat catgaccggc 21781 gtatagaacc gaaccaaaaa tcagtgcgaa aagctgtaag catcatcgga aaagacattt 21841 ttccagacct tttaaaggtt caggaagcgg acaaaaaagg ccaaaatcct cagtacctgg 21901 atgaaaggct taaagtcctt gatgaaataa aggacatctt ttttaatctg gaaaaggaag 21961 gacagatcct aaacttaaaa gaccttgcat taaacggaaa cgaccttctt gcaatgggtt 22021 ttgaacagag ccgggaaata ggtataattc taagagaact ttacaatatt gttcttgaca 22081 accctgaaat gaacacaaaa gaaaagttga ctgaaattgt cgaaaatata agaaaaaaag 22141 ttttaaaaca tagaaaaatc tcaagcgagg tatactcatg attgctcaaa cctttacctt 22201 taaagccaag gacaaaacag aaattttcgt ttataaatgg atgcctgaaa aaggtatcaa 22261 aggtattgtg caaattgccc acggtattgg agaacacggg ggaagatacg aaaattttgc 22321 aagggatctt tcaaactccg ggtacatggt ttatgccaac gaccacaggg aacatggaaa 22381 aactgccaaa accgcatctc agcataattt acaaaaaaga cgcatctgga acctgatggt 22441 tgaagacttg cggcagctta cagagattat ccgaaatgaa aatcccaacg tccctgtgtt 22501 tttctttggg cacagcatgg gaagctttct gttaaggcag tatctgtata aatatcccaa 22561 cagtattgac ggtgccattc tggccggaac cggaatttat gaaaaactcc ttgttgatgc 22621 cgggattctt ataataaaaa ggcttataag caaaggagcg gataaaaaga aaagttacta 22681 cataataaac aaaatactat tcagaggttt taacagcaaa attgacaacc caaaaaccaa 22741 ttttgactgg ctgtccagag acgttaaagt ggttctggat tttataaatg accctttttg 22801 caccattccc cgctcagttg atttcttcct tgagtttttg tacggtatta aagaagtaca 22861 caagaaagaa aacattgaaa aaatccccaa aaacacaccc atttttatca tctccggcga 22921 caaggaccct gtgggccact ggggaagtga catcccgact cttgcacggc tttatggaaa 22981 aaccggtata aaggatgtta catacaagct ctacaaagac gcaagacatg aacttgtcaa 23041 tgaactcaac cgggacgaag tgataaatga tataataatg tggatgaata aaagaaatcc 23101 ttccgcttaa aaataaaaat taaaatacag ccttcatatc attgttacct ttaaggaaca 23161 cagacgatat gaaggctgat tttacgtcct aaaaagtatt tacctttgct ttagtagatt 23221 gcattttaat ttttgtactc tctactatta atttttttgt gctctcgcat ttgctgcaat 23281 agctttatta attgcatcaa tataggctat ggcacttgaa gtaattatgt cggtatgtgt 23341 acctatgccc gtatataatt tttccttttc cctgagagtc acagaaactt cacccaatga 23401 ctccatttct tccgttacgg cggacacact gtatttgtat aacgtaagat tttccgtctc 23461 tttaataaca gaatttatag ctttaaaaac agcatccacc ggtccgtttc ctgtctgctc 23521 ggcttcgagc aaattgccct ttgaatcttt aatcacaact tttgcggaag gcgtctcaat 23581 attgccgctt acaactctta tcttttcaag cacatatgcc tcttccacgg cttttgcggc 23641 ggattcaatt ataagagatt ccaagtccgc cgtagtcaca ttctttttaa cgtcggtaag 23701 ctttttaaaa tcattaaaca gcttgttgag acgttcctca tccaagtcat atccgagttt 23761 ttcagcttcc actttaagag catgccttcc cgagtgcttt ccaaggagaa taacactgtc 23821 atccctgccg acaagccttg gatctattac ttcataagtt gatctttcct tcaggacacc 23881 gtcctgatgt attcccgact catgagtaaa cacattttta ccaactatag gtttgtttac 23941 cggtatgggt attcccatgt atctgctgac aattttactg gttttataca actgtgaaag 24001 atctattccc gtttcaaatc ccagataatc tttccttgcc gcaatgtggg taacaacttc 24061 ctccaaagct gcatttcctg ccctttcacc cacgccgttg atagtacact ctatctgctg 24121 ggcgccattc atagcagcaa caatggagtt ggccacagcc atgcccaggt cgttgtgaca 24181 atggacactt attatagcct tgtcaatatt tcttacattc tttctgattt tttgtatgag 24241 ttctccgaac tcaatgggag ttgcatatcc aacggtgtcc ggaatgttta tgactgtggc 24301 accgttgtct attgccgctt caataacttc ataaaggaac tcgagccttg ttctcgatgc 24361 atccatcggc gagtattcta cctcgtcggt atactgcttt gcatgatata cagtgctttt 24421 tacaatttca agaacgtctt tttccgtttt ccccaactgg tgctttattt gtatgtcgga 24481 gctggatata aaaatatgga aacatttctt ctgagcatct tttatagctt tccaggtctc 24541 atcaatatct cttataattg ctcttgaaaa gccgcatata taaggcccct caacctctct 24601 ggcaattctc tgcacagctt caaaatctcc cggtgatgtc agcgggaatc ccggttcgat 24661 aacatccact ccaagacgtg ccaattgttt tgcaatatcc actttttcct gtatattaag 24721 atttaccccc ggtgtttgtt ctccgtctct taaagttgta tcaaaaattc ttattctcct 24781 catttttatt gacctccttt ataacatgca gatttttctg atttttccta tcattttact 24841 tatgaaacgg ctaatatcat ttttccctaa caaaaaaccc tccgcacctg caaagtatgc 24901 aggggcgaag ggtatctctt cgcggtacca ccctgattcg gcatgattac aacacaaaag 24961 taatcacgcc ctcattttag gtacttgttc gtaccaaacc gtaacgtggt tagcgtcaat 25021 ccctacttat atttcaggat tgaaactccg ggacgagcta tatatgtact ctaatgtatc 25081 ggttctcacc aaccccgact ctctgtgaca atcaagtaca tttttttccc ttcatcgtct 25141 ttatcattat tattttttac atcaacaaat agaaagatta atttcagttc cggaactgtt 25201 tctttcgtat atcaaaaaac ccttcactcc tgcaaacata cgcaggggtg aagggttaaa 25261 ctccacggta ccaccctgat tcggcatgat tacaatacaa aagtaaccat accctcattt 25321 taggtacttg ttcgtaccaa accgtaacgt ggttagcgtc aatccctact tatgtttcag 25381 gattgaaact ccgggacgag ctatatatgt actctaatgt atcggttctc accaaccccg 25441 actctctgtg acaatcaagt acattttttt cccttcattg tctttatcat attttgatat 25501 acttatttaa aattataaat catttttggc taattgtcaa tacatttttt tgtagcttat 25561 taaatttcct gttcatcttg ttgcattttg cttttacact tacggttggc acggaatttt 25621 tacaataaat tcggtgcctt cccccacaac agaatttacc tttatttctc cgttataaag 25681 gtttacaatg tgctttacta ttgaaagacc cagaccggta cctcccattc cccttgacct 25741 tcccttgtcc accctgtaaa agcgctcaaa aattctcggt atatgggccg aaggaattcc 25801 tattcccgta tcttttacgg aaatgacaac ctttccgtcc tccctgtacc cgtcaaccga 25861 taccgagccg ttttgaacat tatattttat tccgttgtcc actaaattca ttatcaactg 25921 tttcatgcgg tttatgtttg ctttcatcaa cacttcatcc cgcacattgt tgttcaggct 25981 gatcttcttc tcctttgcaa tgttttgcat aactttaaaa acatcatcca ccatggattt 26041 taaatcgaag atttccaagt tggtatcttt taactttgtc tcaatttccg acagcagcaa 26101 aatgtcgtta atcaattcgt gaagacgctc agcttcgata tcaatgattt ccaaaaatct 26161 ttccgccaca acaggattat tcatagcacc gtttttcaat gtctcaatga atcctcggat 26221 cgatgttatc ggtgttttta gttcatgggt gacattggaa acaaattcag ttcgaatctg 26281 ctccagcttt cttacctttg ttatgtcctg aataaataca attcctcccg aattatcaat 26341 atcgctgtct ttgggtctta taggtgaagc gtttaccaaa agcacccggc cgtcaattgc 26401 aacttcagcc tccaacggct tatttttctg tattgcatct tttaaaagag aatttatctg 26461 actgttttta atatggtttt caatatcatc tcccaaaatt tcggcatcgg catccaaatt 26521 aaaaacagtg aaagcagcag gatttatcag tataaccttg ttattgccgt ccactgcaac 26581 aattccgttt gttatactct ccacaataga ttcaagctca attttctttg tattcaaatc 26641 agatatggtt ctttcaagct ttgaagccat tttgttaaaa tggacggcaa gctgtcccag 26701 ctcatctttt gattttaact tgattctcct ggaatagttg ccgttggtta tttcctttga 26761 taccgaaata atatcattca acggacgaat tacaagtcct gctatcctca aagacacaat 26821 taccgttatt ataagtgcca taataaaaat taaaattgaa tagagccaaa tcaatctgtt 26881 aattttttta tttgaacaag gggaacagaa actctggcaa ttacattcaa ttcctccaca 26941 ggaattgcca tataaagcaa atccaacttc aaagtcttac tgctgcggat gtctttaccg 27001 acattccctt tgagtgcatc ctgaatctct tttctgctca agtgattttc catttgatta 27061 aaatttgcat ccgaatcacc caacactttt ccgtcataac tgataaaggt aattcttaga 27121 ctctcaccct gaaaggtgga attttggttg tactttgcgg cataatcctt tgcgataaag 27181 tcaaaatcaa tttcgccgtt ctttgcttca ttcaacaaat agtactcaat tgaaaaagct 27241 attccctcaa gtttgttttc cacctcttga gtgtagaact ttcttgagac ctttgggata 27301 aatatgactg tcacagatag gattataaga atcaaaagca aataatattt aaaaattttc 27361 tttttcataa ttactcccga acctctttat cactaaaccg ataacctata cctcttacgg 27421 tttcaatata tacgggattg ttgtcgtcat cttcaatttt ttgtctcaaa tatcttatgt 27481 gcacatccac ggtccttgtt tctccaaaaa agtcaaatcc ccagattttc tgaagcagca 27541 tgtcccgcga aagaactttg cctctgttca taatcaacag ttttaaaagc tcaaactcct 27601 taaaggtcat ttcaattatc tgattgtcct tgtaaacctc gcgcctttca aaatctatgg 27661 ttattcttcc gacattaact cttttaggac tgttttcaaa agaatccgcc tgccttctga 27721 aggcaacctt tacccttgct acaaattccc ggacactaaa gggttttgaa atataatcgt 27781 ccgcgccaag ctcaagcccc aaaaccctgt caagctcatc atttttggca gtaagcataa 27841 ttatgggtat tttctttaag tcataattct ccttgatttt tttgcaaatt tcaaacccgt 27901 ccacacccgg aagcattata tccagaacga agaggtccgg ctttttcctc tccacaacct 27961 caaacatggt ctcaccgtct tcaaagcact ccacctcata gccgttctcc tcaagattaa 28021 accttagcaa ttcctgaata tgcttttcgt cttccactat ataaattaac tttttggcca 28081 tgtcatacac tgcaccttcc tgtagtttac gctctccgct tttgtttgcg gcgcaaccgt 28141 cagtttaaat atattttaca ataacttgta tcttacaaca acttgccatc tggatttcca 28201 tcgggaaagg attgggtttt tgaaacacca ttcccacccg ttttctcaat tccactatat 28261 catactcctt atatacgttc aaactgtgaa aataaacttt ttcagtggtt ttcgcgtcgt 28321 tcagaaggtc gttcattccg ttcagttaat tcaggttaat attattaaaa caaaattaac 28381 ggccaattaa cttcatgtta aatttttgtt aatttgaaat ctacataaga ggggcaaaga 28441 cacgcaggag ggtaccaatc agggttttat accattttgt ctttttaatc atatccattg 28501 ttatttccgt acacacgtca agggtgctta ggaaatcttc ttttatgtca agcacacttt 28561 tgctcttgta tgtccagaca ccacactcaa aatgcagata gaaacttctg taatccatgt 28621 ttatcgtgcc cacaaccgca tattcgtcat cggaaaccaa ggttttggaa tgaataaatc 28681 ccggtgtgta ttcatagatt tttacgccgc tttcaaccag aaagcggtaa tttgaccttg 28741 taacggcatg gacataccat ttatcctcta tatggggagt tataatccgg acatctattc 28801 cggatttcgc tgccgaagcc aatgcctgtg tcattttgta gtcaataaca agatagggtg 28861 ttgtaatata aacatatctt tttgctttgt tcaaaaggtt taaatatact gtctcaccaa 28921 cagtctcatc atcgaaagga ctgtctgaaa acggctgaaa atatccgtcc tcaatttcac 28981 tttctttttt aaacttatag cggaactttt caaaatcttc ctcaatcccc ctaagataat 29041 cccacataga caaaaacatt accgtcatgt tccatacggc ttcccctttt atcattatgg 29101 cagtatcttt ccagtgtccg tgctttttaa tctcattgat gtattcgtct gcaaggttga 29161 tgccgccggt aaaagccgta tgcccgtcaa ttatcgctat tttccggtga tcccggttgt 29221 ttattttggc agacaatatc ggagacacag ggttaaaaac acaacacttg attcccatac 29281 tttcaagctt tttgttgtaa tttcgcggca aaaacagcaa acaccccata tcatcgtaga 29341 taagacgaac atctacccca ttttttgctt tctccaccag tatctccaat atactgttcc 29401 acataattcc ttcctgaatg ataaaatact ccataaatat aaaatgcttt gcttttttaa 29461 gttcctcctt aagcttttca tacttttttt ctccgatgga aaggtattcc gccgtggaat 29521 ttttatgggg aggatagtgg gctacatttt gaatatacct tgactgaacg gccgcgccgt 29581 cgtcatgcag cattatttca cttaaaacct ccggctgcag caccaaagca ttctccacct 29641 tcataccaat ggatttcagc tttcttctct cgcgcctgct aagcttcttt cctccgaaaa 29701 aaatatagaa caatccgcca aaaataggaa acaaaagtat cggaataatc catgcaattt 29761 tgtaggaggg attgcttttt ccgttcaaaa tcaaaaatac tgcaatcatg cttataatca 29821 ggcatgccca atagaagaac acaaaatagt cgttaaactt caatacaaca cttacaagag 29881 caatcaactg tataagtatt gccaaagata ttaaaacaac tctgtgatac aaaaatttta 29941 caatagattt tatccttgac cacattaagg attcagcccc ttgatttgtc aatagtaacc 30001 agatttaata cttcgtattc attgccaatt tttcgtagtg tttgtacaaa gaatgaaact 30061 tgccactgta agattttttc catggttttt tctttccgca aaaatgaata aacaccgtgt 30121 tgtttattac gtaatccatg tcgcacttgc cgttgcttgt aattttataa taactgtaat 30181 atcttgcgtc ataattatat aatttttcat caatactctt tatcttttta gaatacaaag 30241 aatttataat atcctgatcc ggcataataa gttttgagcg gttatttttt acaaaatcaa 30301 aaatttcctc ctctgaaatc gtttcccgct gaagtttcag attcatcagt aaaacaccgg 30361 aattatagta ttcttttata tcatacgcat tgagccttat cctgttgatt ctttttattg 30421 ttattatgtt gtgatacgcc gcagcgtaca aatagttgtc aatatccatg ttgtaaagct 30481 catcaatcgg atttataact aagatatccg ggtccagata caatatacgg tccaattcct 30541 ccggcaaaaa tttaaatgcc aaaagcctgt agtacattgc cttcgtgtag tgaagaagtg 30601 tcggggcatc ttcaaaataa ctgtcgttta tttgtacaat tttcaatctg ccgccctctg 30661 cctcgatgaa cctgtccaag tcctcaagtt cttcttcttt tatgctggaa tgcatcaaat 30721 atatgtcaaa ctcttcgttt ggattattga taaagagcga ttttagcatt acttttaaag 30781 gctttaaata attggaatcc aatgtaacaa gtatgctctt cattattatc cactcccgat 30841 cccaaatctt atgcaacatt gagaacattt tttacaggca ttctattatt aactttattc 30901 tcctttcaat tcacaataac aataataaca cataaaaaat attttttcta agcttatata 30961 aagcccttta aagcaaataa aaaaaccctg cagaaaactt tgcagggtta acacgatatt 31021 ttaaatttat cattgttcgt gagagactaa gttttcacta ttttttcggc agctccggaa 31081 tggcttgaag cagatacttc tttaggtatg tatagtctgt ggaatttatt ttgccgtcgc 31141 cgtttatgtc cgccgcccat aaatcatctt cgacaggtaa atcttctatc gatttaagga 31201 tatatctctt cataagagta aggtctgttg aatttattcg attgtcaccg ttcaagtcgc 31261 ccaccaggcc tttgtcaacc tgcggaggag tgggtacagg ctcatctgaa gcaggttcgc 31321 cgtaaacaat acctcttccg ttggtggcaa tatatacacg tccgtatact ctcgggtcac 31381 ctgttattgc agtatcaaca gcgccatatc cgtgctcgtc gtcgttgata cgcacccatg 31441 tcttgccggc atcatcggaa cggaagaatc ctaaaacatt gtcaatttta ccggtaatgt 31501 aaatcgccat gtaatcctgt cccggtgctg cctttccgaa gcctaccaca tgagctgtgt 31561 caacattgga gagtttctca aacgtatatc caccgtcagt ggacctccac aatccgcctt 31621 ctcttgcagc aagccataca tgtccttcct tgcccggtac ggcttttatc ttgttaaccg 31681 acttgggaag ctgcggtgcc tttgtatcgg taaaggttaa tccaccgtcc gtgcttatat 31741 agaatttgcc gttatagaat gcgtagaatt ttttaccgtt cacacggtcg gatgccacca 31801 ccgcacccat accaagattt gtacaaactt tccatgagtt tccgttgtcc gttgtaactg 31861 caggacttgc attttccggt gtccaaataa ctgattttgc atcggctgca acggcaaccg 31921 aaccgccgcc taccgagttt ggtgcttcat taggtggctg gaaccaattc cttcctccgt 31981 cataagagaa agaaatcttc tttacatcat acaaatcagc ctttgcaacc aatgccataa 32041 agttcggaac aagctccgca taatcaattc ccgtacctga agaataagaa ggaacgtgca 32101 tttttttcgg accaactttc aggtcatcat gaacaaaacc gacaaggtcg ccaactgcac 32161 ttacaagcgg tgcaccctcc ggcgggctta ccaggtctaa taccgcacat tcttctattc 32221 cggtagcttt tacctcgatt tttactttgc cgcctctgtc ccagtcagta agattgtcac 32281 aaccatagat agttgcaccg gtaacataca tcatgcggtc ggaattaaac gggtcaatct 32341 ctatgtcacc tatcatccat cccagtttcg gattgatttc cggcagctgt ttctcagttc 32401 cccaatccag ccacggtgct gcggaaatat ctatttcata atgcagtata cgttcaggat 32461 acattcccca ttcccagata ttcttccatg tagctccgcc gtcagtactg cggaaaatat 32521 attcatccgg ccaccacgcg ttcatggaag ttaccattat aatgtcagga ttctgcctgt 32581 ccactgcaag tcctgcaaag cagaaacgat tgtcactgct tgaataaggt atcggggtga 32641 tatctatcca ttcccctgta cgtgtattga acttccaaac ctgacctttt ccgttgccgt 32701 cataaggacc gcaggtatca ccataagtta tatacaacat tccgttggat gccaaaaccc 32761 cgtggtgagg aagtagtccc ttaggttgtc cgggaactgc tttccaggtg acacccccgt 32821 ccgtactgcg gtaaatactt tcgtttttat cagccacacc aacatatata gtcttggtag 32881 ggttgcccgg tgtactgctg ctcttgtcaa aaacaaccca gactactcca ataatgtctt 32941 tggtataatc aaaattcggg tcataaatgt aagttccggg atttgggaaa ctttcaacct 33001 tggaccatgt tacaccgtag tcggtacttc tccaaagtcc gtttccgcat cgtgttccaa 33061 gataaagaat cctgttgtca ttcgggtcga tcgcaagacg ttctcccatg gatcttcccg 33121 gcatgtttcc gcccatcttg aaaggcagta tggttttttc ccatgtttct cccctgtccg 33181 ttgagcgaag aattgctccc atattaggaa gccaatcgtt ggtatacata cctgcagcta 33241 tgtaaacacg gttcggatcc acagggtcgg ttgcaatact ttccactccg taataactgt 33301 actcatccat ttggaaatgg tccagcaacg gaatccatgt ctcggtcgaa ggatcccacc 33361 ggtacgctcc tccgatatcg gcacgtgcat aaatcaaatc cttttccgtt tcattaaaaa 33421 ctatacccgg cataaatcct ccgcctccgc cgattaccac gttgtcccat ttgtaaggca 33481 cgctggttac agcctggctg gaaatcgcgg ggccaaatat tgccgttgca gcaactacag 33541 ccgcaaaaac agcagcctta attttacttg taaacttttt aaccattaag cgctcctccc 33601 ttaaaaactg attaaaaatt ttctctcaaa cctgcctgtt tacaaccgct ttttataaaa 33661 caacctccct cccattggta tttaaacaaa caggtgcctt gtctatatta aaaagattaa 33721 ttatgtccct cttcgctata taaattcgga cctgtacttt cctttgatgt acccgtaatt 33781 ttattaattt tttattttaa aaatcaaaaa agaaagacgg caaaaaccaa tctttctttt 33841 tttgactctt ctttcgttac ttattgattt ttattaattt ggttaattat ttttgttaat 33901 taataaactt gtaataaaat accattgatg caaattacgt ttttaacaac tcatcaacaa 33961 tttcagccgc acttcttact atttccgcac atggccgctt tttataataa ccctccgtcc 34021 ttttctcagg ttcaggtttg tcatgaacca cattgagtcc caaaagctct ctgcatatta 34081 tagaaccgtt ctcttcctta aacctttcca caagtttttg gaccaactca taatgctcct 34141 tttttgcatt catgtccttc gggtccacat acccgtactt taatccggca atcataaaca 34201 tggccgaggc agctccgcaa acctctctga gtcttccgat accgcctcca aagggagaag 34261 caatcattaa tgcagttttc atgtcaattc caacatcttc gcaatatgcc gcaagaaccg 34321 cctgggaaca attgtatcct tccttaaaca actcaacagc ccgttcggat ttaccgttca 34381 aaaatatccc tccgttttga cccctgtcct ctaattgctc catactacta ttatatacca 34441 atgagcataa caataccagt cccacggata ccggtatgtc aatatattat ttctatttta 34501 caggaagtga tggtatggca ttgagtaaat atctttttag cacagtataa tcagtcgaat 34561 tgatacgacc gtccaaattc aggtccgcag ccttaattcc cctttcataa gggaaagttt 34621 gtatagcgcc aagcaaatat ctcttcagca aagtgtagtc cgtggaattc acgcgtccgt 34681 caccgttcaa atctccataa ataagattat ccggtgtatc ggaggtcaaa aacgcatcca 34741 gcgcaattgt gggttttccg gataaatcaa aggctccttt attataatac tgccagttat 34801 aacattgagg ctcccagtag aatactccaa ggcctttatt atcgggcagg gattttgtct 34861 tttgaattat atcggtaata aagtctttgc aagcctgcgc ctcccagtaa tccattccaa 34921 tctcacatat cattatttct tttccgtatc ttgatatcat gtctttcata ttgtttagac 34981 actggtttgt caattgtggc cagtcagacg ccgtaggata cagcgacata cctattacgt 35041 caaatcttgc accgtttgcg gtaattccat caaatatcca tctgtacaat gcattgtcat 35101 atccatttgc aatatgaact ataactttag tttcaggact taccgctttt acggcatcat 35161 aaccgcagtt gatgagccat gcaaaattcc tcatgctgtt cgttgccttg ccgtcttccc 35221 acagcatgcc gttattggtt tcatttccaa cctgaaccca ctcgggagtt atgccgttgg 35281 ctttcaaagc gctcatgaca tcatatgtat agtcatatac agctttcatc aagccgttaa 35341 aatcatattt ggcccatgct gccggttttg tttgtttccc cgggtcggcc catgagtcac 35401 tgtaatgaaa gtttatcatt attctgaatc ccattttttt agctcttaat gccatcttaa 35461 ttgtctcttc tttgttgcag taaccgtttg gaggattgac ccataccctg agtctgattg 35521 agtctatccc atggtctttt aaaatttgaa gacaatcctg ctcaatcccg tcgtcattat 35581 aaaatttgta gccgtttgcc tccatctccg gcagccagct tacatcagcc ccctttgcaa 35641 aagttggagc cgcttgtgtg taagttttgg gcattgaaag aaatgtgaca gacaggatga 35701 ggataaagat aacagtaagt tttgtaattt tcgataacat agagcccccc tatatttaca 35761 tcttttgatt tttggattat catatgtaca aatttattgt atcataaatt ggaggttcta 35821 taaattgtat gtaatataaa caaaagaaat aattatttga ttgtgtgact gtatttagat 35881 gctgttggct cataagttcc tattgatatc aagtattcaa actttctgcc tggagatttt 35941 gctgttgtac atggttttta tgttcgtcga tgtggagtag tgcaaaaaag ccgggggatc 36001 gacaaaattt attaatgtgc ctcaaatgct gatttatagg tctcttgaga gagttttttt 36061 gttctgattg ttgatttttg ttttatatag agttaaaata taaagcagaa gtttagcgag 36121 ttctatgggg tttttatcgt acctatgagg aattgaaact cttcatcatc ggatatcttt 36181 ctttccattt ttggacgttt ttatcgtacc tatgaggaat tgaaactttg ttatagagag 36241 tcatttaatc aatattgaat taggttttta tcgtacctat gaggaattga aactgacagc 36301 ccaaacgaaa aacccaattg ctacattcag tttttatcgt acctatgagg aattgaaact 36361 tttgaagata attttggaga acgggctgca agagagtttt tatcgtacct atgaggaatt 36421 gaaactttca tttagaactt gattcgtcat atcatctctg agtttttatc gtacctatga 36481 ggaattgaaa cccaagaaaa gcggcgacaa gattacttcg attaaaccgt ttttatcgta 36541 cctatgagga attgaaacat tttttcaagg atgtattcga tgtcttcatc tcttccgttt 36601 ttatcgtacc tatgaggaat tgaaactagc ttcgcatgaa gtttgattgt atcacgctat 36661 tgagttttta tcgtacctat gaggaattga aacatatatc tactttctga aaacctcctc 36721 acaaaacaac gtttttatcg tacctatgag gaattgaaac taagaactag tctatcagaa 36781 atatcaccat ttaaagagtt tttatcgtac ctatgaggaa ttgaaaccag atgggatgaa 36841 taaggtcttt aaatcctctt ttagttttta tcgtacctat gaggaattga aaccaatata 36901 tatcagcatt ttccaaaatc caatccattg tttttatcgt acctatgagg aattgaaact 36961 cttgatgact attttggatg gtttgatccc gttgcttgtt tttatcgtac ctatgaggaa 37021 ttgaaaccac tttttgaaag tataaatgag gaggtattga aaggttttta tcgtacctat 37081 gaggaattga aacatcagtc taatactgga cgtaaatata taggtgctat cgtttttatc 37141 gtacctatga ggaattgaaa cgtatcaaca gtaaattccc catcatacac cttattgggt 37201 ttttatcgta cctatgagga attgaaacgg gtcatcccct ggaagggaga attccgcact 37261 tccaaggttt ttatcgtacc tatgaggaat tgaaacaaat tactattgac agtataaaaa 37321 tatatgatac aagtttttat cgtacctatg aggaattgaa acactattac aaaggcaaaa 37381 ttgcttagaa atgaggaggt ttttatcgta cctatgagga attgaaacgc atttgaacat 37441 atcatgacct tccccgaggc agaagttttt atcgtaccta tgaggaattg aaactccctg 37501 atttcaattc tgccgataag ttcaaatcca gcccgttttt atcgtaccta tgaggaattg 37561 aaacactctt cttccatccg aataggtaat acagtcaatt cggtttttat cgtacctatg 37621 aggaattgaa actttgtcag tctgattttg atgttcaaac tgtattcccc gtttttatcg 37681 tacctatgag gaattgaaac cacacgcttt ccaatccttg attggttttc ttgcctgttt 37741 ttatcgtacc tatgaggaat tgaaaccgct gatatgtgct gcgacggctc atatgtatat 37801 gcaggttttt atcgtaccta tgaggaattg aaacttttga ctggtccagg ttccacccat 37861 attatcactc cgtttttatc gtacctatga ggaattgaaa ctacctgatt ttgcagtatg 37921 cggtagtcac tatttcggtt tttatcgtac ctatgaggaa ttgaaactag tgtcaatgtt 37981 cttccaaact tcttcaggga ggtgttttta tcgtacctat gaggaattga aacagtattt 38041 cctgcaaggc ttcttctgca tctactatag tttttatcgt acctatgagg aattgaaact 38101 aagcatcatg atggataagg tcggtacctt cccgagtttt tatcgtacct atgaggaatt 38161 gaaacaagca gtttgccaaa tcctatcact aagttgagtc acagttttta tcgtacctat 38221 gaggaattga aactgctaat tagctcgttg ccgcatagcg caattatcag tttttatcgt 38281 acctatgagg aattgaaact atgttcacat gggatacatc ggtatatccg tgggttcgtt 38341 tttatcgtac ctatgaggaa ttgaaactag atgaatcaaa tagttctact gaacttggag 38401 atacgttttt atcgtaccta tgaggaattg aaactttctt tttcttgcca tatcctggca 38461 atttctatac gtttttatcg tacctatgag gaattgaaac acaaataatt ttactatgcg 38521 ccaagtaatt ggatatatcg cgtttttatc gtacctatga ggaattgaaa cacctcccgg 38581 acaaaaactt atccggcgac gggccgagtt tttatcgtac ctatgaggaa ttgaaactgg 38641 tgtcagaaca tcccgggaat tcggtttgaa gattcgtttt tatcgtacct atgaggaatt 38701 gaaactggcg ccttgggcgc ctgtaaccat aatttcgcag gagtttttat cgtacctatg 38761 aggaattgaa actccaccac tgtccagagt aaaaaaaagt agaacagagt ttttatcgta 38821 cctatgagga attgaaaccg gcaatcttct gtcgcagttg gctgttacgc ggaagttttt 38881 atcgtaccta tgaggaattg aaacatccga cagtgaaaac attcactttt gatttatatg 38941 aagtttttat cgtacctatg aggaattgaa acgcattgga ctgattctgc atatcgctat 39001 caactccttt gtttttatcg tacctatgag gaattgaaac aattgtggga tagcaccggc 39061 ctgatcaacc ggtgcgagtt tttatcgtac ctatgaggaa ttgaaacgcc tgccactgct 39121 cccatctgaa accttcctcc tcttgttttt atcgtaccta tgaggaattg aaacgctttt 39181 agcttacttt ctaatacgta gccataattc cgtttttatc gtacctatga ggaattgaaa 39241 cttccgccgt tgcctcgctt ccgtccggag ctggcgggtt tttatcgtac ctatgaggaa 39301 ttgaaacccg cccccggaat gggcttgggt gtgtcataag taagttttta tcgtacctat 39361 gaggaattga aacattccag cgattcggcc atcgatatga gcgccaggtt ggtttttatc 39421 gtacctatga ggaattgaaa cggctttcct gccaaagttg ttcctgcttc tgcgaagcgt 39481 ttttatcgta cctatgagga attgaaaccc acctgcagag ttagaaccat ttatacgcag 39541 aaagggtttt tatcgtacct atgaggaatt gaaactattc tgacacatca atttgcttga 39601 gttcagtgat ttgtttttat cgtacctatg aggaattgaa actcaacgag aacgatgtca 39661 tcaacaatgt gcgggccagg tttttatcgt acctatgagg aattgaaacg cagtttctga 39721 tacgtttcat tgctggtccg aaccggtttt tatcgtacct atgaggaatt gaaactttca 39781 aaccttacaa cttgttgcat aacaaattct ccgtttttat cgtacctatg aggaattgaa 39841 actctatcga tgcgagttct tcatgccgta gttccaatga gtttttatcg tacctatgag 39901 gaattgaaac aaacaaattg caattataaa aaaataggga atcacagttt ttatcgtacc 39961 tatgaggaat tgaaactgcg atcaagtaca ctgttaagac tatcaggctt cgtttttatc 40021 gtacctatga ggaattgaaa caaataaatt tgtcgctgcc tgagccaatt tcaacacgtt 40081 tttatcgtac ctatgaggaa ttgaaacaag atttcatttt tgcaatacct tatgaaacat 40141 ttggtgtttt tatcgtacct atgaggaatt gaaacatcta acagtccagc tgccttgagg 40201 tcgcttattt tgtttttatc gtacctatga ggaattgaaa cgggacgtca acactccgaa 40261 aggcggctag aagtggacgg tttttatcgt acctatgagg aattgaaacg ccatatatac 40321 accccctaca agtagcttgg agcaagtttt tatcgtacct atgaggaatt gaaacagctt 40381 gtccgcaggc ttttcttcct tgggctcttc gtttttatcg tacctatgag gaattgaaac 40441 catttccatc aaccttaata agcacgtctt caggtagttt ttatcgtacc tatgaggaat 40501 tgaaacttgt caactaagca tgcgaactgc tccgagccat tgtttttatc gtacctatga 40561 ggaattgaaa ccccaaaaca tattcatcca agttattcgt gcagtttagt ttttatcgta 40621 cctatgagga attgaaacgc tgtagttact tctgtcccgt tttctctaat actagttttt 40681 atcgtaccta tgaggaattg aaacccgttt tcatccttga acctatcaga tactacaaac 40741 tcgtttttat cgtacctatg aggaattgaa acaatccaat agtagtgcta atagttcccc 40801 atcctccgtg tttttatcgt acctatgagg aattgaaaca catacaaagg tatatcccat 40861 ctttttcact gtttcaaagt ttttatcgta cctatgagga attgaaacca gacgacagct 40921 ttttacctat cctttatgag ctgggttttt atcgtaccta tgaggaattg aaactcgtac 40981 tgtagacggt gaaatacaaa tcattcctga gtttttagtt tttatcgtac ctatgaggaa 41041 ttgaaaccgc agtagtctgc tgtcagttct atccctgctg cgggttttta tcgtacctat 41101 gaggaattga aacatttata aaggagagat tatgtggcaa agataacaga gtttttatcg 41161 tacctatgag gaattgaaac tgacaaagta aaagcaatag ctgatgagcg taacttaact 41221 agtttttatc gtacctatga ggaattgaaa cgtgagtact tgtgaacaat cacgagtttc 41281 tcaggtgtgt ttttatcgta cctatgagga attgaaacgt gaattccgat gctgtttccc 41341 tttcgggtaa gttttgtttt tatcgtgcct atgaggaatt aaaacacaat agataccgtc 41401 cccgtgctaa tttcatcata gttttgttgt gcctataata taaattgaaa ttaatgcaaa 41461 tattgacata tcctataact atttattttt tcatgcctat aaactaaatc aataacatta 41521 taggtactcc gaaaaaaaat ctattgactt tttgatatcc caatgttatc ctcacattag 41581 cccaaaaaat ctttgaaaga aggtgctcca acatttacgc tctttttata gtgttaaacg 41641 aagttgatta tcttgatgat attctggcca aatttgttga cgtgggagta agcggtgcaa 41701 caattttgca cagccaggga atggcaagcg ccatcgtcaa cagtgaaaat aacaaaatct 41761 cactctttag cgctttaaaa agcattatag aaaatattcg tccatataac aaaaccatct 41821 ttacagtttt ggaaagcgaa gaattggtgg aaaaagccgt atccgccgtt caaagtgtga 41881 taggaaaggc gcccacatcc ggagtaggtt ttatgtttac tgtccccatt ggaaaaatat 41941 atcccatggg cttgcaggaa taaaaccaga ataaaaagaa atcagccgca aagtattatt 42001 tctttgcttt tttattttta tatcgccgga atttttccaa aatttcagga tactcttcaa 42061 aaaagctgtt cagctcatca atacttctta aagtgtcaac actgagatta tgttcaataa 42121 gctccgtttc tatcaaaagg ttgtcactga ttccgatact tcttaaaaat ttttcaatta 42181 tattgtgcct tttcagaaga aactcgccca gtgcttttcc tttttctgta agagtaataa 42241 taccatacct cttatactct acaaatcctt tttcagaaag tttttgaacc attttagttg 42301 ccgatgaagg ccttacattc aacatctccg ccaacgtatt gatgcgcata tatccttcct 42361 tttttatatt tctgaaaatc atttcaagat aatcctccat ggcagatgtc agaagttttt 42421 tctcctgttc gataagctga tatcctctga ccgtgtgaaa ttcgctgttt tccattttta 42481 ccaccgttcc cgcttgaatg aatatttttt aattaattta tattcgtaac actgtcattt 42541 tatatttcat atattagtct tgagaaacaa aatttctctc cgcttatttt gacaatataa 42601 caaataaaca taatacgttt cggaggtagt tgttatggcc ggaaaacaaa ttacattagc 42661 ttccttgccc ataggaaaaa aagcaagagt aaaatccctt accctggatg gaacaatacg 42721 caggagaata atggatctcg gactggtttc agatactatt gtggaggctt tgcaaaaaag 42781 tccttccggt gaccctaccg cttatcatat tcgtggtgcg gtaattgccc ttcgttccga 42841 agaagcgagt aaaatcatgg tcgaagtaaa ttaacaatcc aataaatctg gtccaacagg 42901 gagttctcct caagtttggc agaactccct aaaataaata ttcaggaggt ttaaaaatgg 42961 ggcttacgag tcaatccaca ggagcaggtg ttctggaaaa caaacttacc attgtaaaaa 43021 gcacgcctgt tgacaaagtc atagcacttg ccggaaaccc caacgttggt aaaagcacgg 43081 tattcaacag tcttacggga ttgaaccaac acacgggaaa ctggccgggc aagactgtca 43141 ccaacgccca gggaagatac aaacataaag ataaaaactt tatcatggtt gatataccgg 43201 gtacatattc tctcatggcc aactcagtgg aagaagaagt ggcaagggat tttgtatgct 43261 ttggccagcc tgacgccacc gttgttgtaa ctgacgccac atgccttgag agaaatttga 43321 acctggtgct ccaaaccctt gaaatcacaa acaaagttgt cgtttgcgtt aacttaatcg 43381 atgaagcaga aagaaaaaaa taaaaattga ctacaacaaa ctttcaaagc atctgggggt 43441 tcctgtcatt cctacaaatg ccagaagcaa cgaaggactt gacaaactaa tggatgcagt 43501 ttatgaaatt tcaaccaaag aaacaacatc ccatcctata aaaattacct atgatgacat 43561 tgtggaagag gcaattaaaa tgattcagcc aaaaattgaa acgatagccg gagaaaaaat 43621 taacagccgt tgggtggcac ttaagctttt ggacaatgac ggtgctttgc tggagtcatt 43681 gaacaatttc ctcggtttta atcttctgga tgataacgaa cttgcagaac ttgtagacat 43741 ggcaaaaaaa caccttttga ataacggtat cgggcaaaat cagcttagag ataaaattgt 43801 tacacggctg gtgaaaattg cagaagaaat ctgccaaagc gtaattacct ttgagaacaa 43861 acaatacgac catttagaca ggaaaataga caaaatcctg acatcaaggg ttttcggaat 43921 acccgtcatg cttgccatgc ttggggtaat tttctggatt acaatcacag gagcaaacta 43981 tccttcacaa atgctttcaa ctttattttt ctggatagag gaaagactaa ccgacttttt 44041 tgtatgggca aaagctccca aatggcttca tggattgttg gtgacgggag cctacagaac 44101 tttggcatgg gttgtatcgg ttatgttgcc tccgatggcc atattcttcc cattgtttac 44161 tctgctcgaa gacctggggt atcttcccag agttgctttt aaccttgaca atttctttaa 44221 gaaagcttgc gctcacggca aacaatctct gaccatgtgc atgggttttg gctgcaatgc 44281 cgccggagtc attggatgcc gaataatcga ctcaccgcgc gaaaggctga tagccacaat 44341 taccaacaat tttgtaccct gcaacggtcg tttcccaact ctgattgcaa taataaccat 44401 gttctttgtg ggaaattttg caggtttttc tcaatcggtg ctttcaacgc tctttttgac 44461 cggagtaatc cttttgggta ttgtgatgac gttgcttgtt tcaaaacttc tgtccaaaac 44521 aatattaaaa ggacttcctt cttccttcgc cctagaactt ccgccgtacc ggaagcccca 44581 aataggcaga attatcgtaa ggtccatatt tgacagaact ttgttcgtgc ttggcagggc 44641 tgtttcagta gccattcccg cagggtttgt aatatggatt atggcaaaca tttatgttgg 44701 agaacaaagc ctgttatccc tttgcgcagg tttcctcgat ccctttgcca gattaatcgg 44761 actggacggc tacatcctaa tggctttcat tctcggtttt cctgccaatg aaatcgtggt 44821 tccgataatt ataatgagct atatgtcatc tgaaagcatg atggaacttg aaaacttaaa 44881 tcagctaaaa cagctgcttg tggacaacgg ctggacttgg gtcacggcac tgtgtgtcat 44941 gctgttctcc ctgatgcatt ggccttgcag taccacctgt ctgaccatta gaaaagaaac 45001 acagagctgg aaatggactt tagtatcatt tttagttccg actctgtcag gtattgtaat 45061 ttgttttata gttgcgaatt tggcaagact tctggcactg gtttaaaaac aaatatttaa 45121 ggagagtaca cactctccta tgctctatat tttcttcttt taaattttgc aacaaatatc 45181 aatcccggaa taagtgcggc aaccgacaat attaaaactg tactttgagt ttcggattgt 45241 tggttgtcgc gaaacatttc catgccacca cggaaccgca tattgccagg tggctgcata 45301 ccgttcggca tttgcattcc gttcggcatc tgtccaccat ccggcatttg cataccatcc 45361 ggtatctgca ttccgtccgg catttgcata tcatccggca tctgtattcc gtccggtatt 45421 tgcataccac ccggtatctg tattccgtcc ggcattcgca tatcacccgg tatctgcatt 45481 ccgtccggca tctgcatgtt acggggcggc tgcatgcctc ctctcatacc gcccatgcct 45541 cccatatccg acagattcaa cgtcgtttct atgctgccat atgaggtcga aggctggctt 45601 ccttcaagtt gagccaaaat actttttgcc ctgtcctttc caaaggtcag aatcgcctgt 45661 acacccttct gatattcctc aaacgtataa aacgcagttg catcattctt tacataatca 45721 ctgataagcg catttattct gtttatggaa ttttcatata cgccactata aatatacttt 45781 tccacaatct ctcttaaata accatgataa cgttccctgt attcaggcac ctccaagagc 45841 ttgcctatga gcggagcgtt ctccaaattt cccgttacag gattatctat cggaaaattc 45901 accgcacgag aagcatcatt tattccaaaa ccggcaaatg acaggttgaa atcccagggc 45961 aaaattaaaa acaccccgtt ctcttcataa agataataat tgtgatacat gcctccactg 46021 taaccatcca gattgaccag gaatgtattc accgcccaga atctcagtat ttcatccaca 46081 tcaagatatt tctcaaggtc ggtcccctca ttgagtttct taatcatctc aatcactttt 46141 ttaaagtctg catccgtagt ggttttgaaa accgcattgt ttcttatggc ccaataactg 46201 gacggggaat catctatata tttcaggtcg gcaccgcctc ttgctcccat tctgccaaat 46261 ccgcctataa aaccgccaaa tctcccctga gccccgaatc cattcggtat ctgctgcatt 46321 cgggattcat ttgagttttg ctcttttgtt tcttgatttt gaatctggtt tgttccgtcc 46381 ctatttggta tctgatctct tcccggtctg tctggcatct gttctctttc ggctccaccc 46441 ggcatctgcc gcattccgaa ttgatttggc acttgttctc ttccggcttc attttgcctc 46501 tgttccgctc cgggggcatt ttgcatctgt tctctgcggc ctctcataaa cggcattgcg 46561 ttggggccgc cgttttgctg tccacctcgc tcttctccgc ggtctcctcc aatctccata 46621 gcctcaggtt tatacaaatt gccgtttacg cttccaaaat gcctttcaat atagctttca 46681 tcaattactt caacagcaag atacaatccc cagtccttac cgtttattct gatgttggaa 46741 tacgcacatg ccgacgaagg tacccccata aaatcaaaca gcttatagga aagatattct 46801 ttcatatatg tcttatccga cataatgttg tttaaaacta ttttctccgc cccgtaatat 46861 gtctgtccgt cgatatattc actaaaatca agcttgaaac taaaacgctt cgaatcactt 46921 cttgcaatct gtgaaagact ggaatttccc tttggcctga tacccacatt ataaaaggtc 46981 tcaccgttaa ttgttacatt gcagcttcta tattcctcca aagtagcatt ttccaatagc 47041 cattcgaaat cattctcatc catttcaatg tttatttcgt ttaccacatt gtcgttaaat 47101 atcttgtata tataatccgg ctgcgcatca gcttctgctg catttggaaa agcttttgga 47161 acaagagcca taccggttat aaggagagct atgcatagta tcgttaccac tatcttgaaa 47221 accattttta gatttacatt ttcatccaaa tatatcacct ctccttcata ctgaccgaca 47281 agtcatctta actcatataa tctccgttat agcttaccat aacagcactt aaaaccccat 47341 tttgtctgct tatctcattt acaaattccg tttccatgct ttttaggcgt acttcaaccg 47401 caacctctat tccttttcct cccgttatgg tctttgactt tacaacatat ttccttactt 47461 tatctttgat tatattcatc acattgcttt ctgccttgtc atcttcgcag tttaccacca 47521 aaatataagg attgtcggta ctgttcctgt ttacaaacaa taccagtatt attccgataa 47581 agagtgaacc gaacacagcc aaaggtatga gccctgctcc caatactata ccaactgcta 47641 ttgaccagaa aagatatgca atgtccatag ggtcctttat agctgaacgg aatcttacaa 47701 tcgacagagc accaaccata ccgagggaca gcaccacatt ggaagtcact gcaagtatca 47761 tcagggtggt tatcattgtg agagctatca gtgaaatgct gaaggttctt gaatacatga 47821 ctcctttata agttttcttg tacacaaaat atatgaacag gccgatacaa aacgccaatc 47881 caaaagcaat agcagcatcc aacagcgaaa cactcgacac cttctccaaa aagcttgatt 47941 tgaaaatatc attgaagttt atctgatttc tcatactttt cctccttaaa aaatgttatt 48001 ttgttaataa tacatcctgc aaagagcgta ttttgacact gaaagttttt gacggtcacc 48061 aatctgtaga atatcattta ttatctcagg gagaaattca tcatacttta cttcaagcaa 48121 cgccagctgc cgagggagag tttccaccgt gggaagttcc ctgttaaaca aatcattgct 48181 cacaagcccc gtccttatgg atttatcaat tgtaaccctt acgtttccag ggttgtaaac 48241 ataggcttcc ctgatataat ccacaatggt acgcggcttt agctgctgat gcagcatctt 48301 atggtatatc tcaaccaata acggatcatc tgagtttttc atccattcaa tatttccatt 48361 taatatatct ttgcattgct cttttgtgat atttgcgctg aatttggctg taaggccgtt 48421 tacctttatc tttttctcaa gctttataaa caaattatca tgattataca gacggatacg 48481 gattttttcg cggttatcca ctccgtcaat tttctccatc agtgccttgt ctgccggagt 48541 atcaaaatac aagctccgta caaggtaaga cccgtcaggt cccgcatttg aatccgtctt 48601 catgacacat cttaattttc ttctcagtaa caggcaatcc cccgcattga tataatgctt 48661 tatctcatgg cggaatttta ctttttccat tgaatcaccc ctcttacctc aaatcatata 48721 aacaaccctt tttatctaca gaataatttt agcacctcac accgatacaa atctccgcaa 48781 aaatgtggca aatgtatggc acaagattaa agaccatgat atttcatttt gtccatgata 48841 aaatatattt tgaggtggat tttatatgga aaacaaaaaa ctaatctata tcgccgacga 48901 tgagataaat atctgcaaca ttataaagtc ctttcttgtt aaagaaggat acgacgttga 48961 aactttcacc gacgggcgtt caatactgga agctttcaat aaaaagcctg cagatttact 49021 tgtaatagat ataatgatgc cagaaataga cggattttcc ctttgttcaa caatccgccg 49081 tcaaagctcc gttccaatta taattgtatc cgccaaggat actgagccgg acaaaatagc 49141 aggcctcacg ctgggcagtg acgattacct tacaaagcct ttcagtccca tggaactcat 49201 tgccaggata aaaagcatat tcagaagaat agaactggac aaaatgcata atgactcggt 49261 acgggaaatc agaattggag atattgtcat aaatgtcgat aaaaaacagg ctgaatttaa 49321 cgggaaaaac atcggactta ccggcacgga attcaatctg ctctattacc ttgccaaaaa 49381 caaaaacagg gcggtaagcc gcagtgaact tctggacaag gtatggggct ttgaaaatta 49441 tgtggaaacg agggccactg acgacacgat aaaaagactt agaaaaaagc tttccgacag 49501 cggttcttct cttaaaattg aaacggtgtg gggttttggt ttcaaagtta atgaagaagg 49561 atgattttat gaagaaaaat acaattaaat ggagaatttt caaatacaac attattgcaa 49621 tttcggtttt attggcattg acaactatcg tgttcaatat taccatccag tcctatatca 49681 aaaacgacat taaggagcag ctaagtacaa ttgctcaacg cgttgaagac actgctttgt 49741 acaggggacc cgactttttc cctccccagg aaccgcaaag gccccgtcct ttgccgggca 49801 ggcaaaacgg tatgtttcgg gaaaataacg atttattcag gttttatttc tttttggacc 49861 gttccttaag agaacctctt tcgattttaa acgccgattt tatacttctt gacaacaaca 49921 tggacataat cacgccgccg gaaggagact ttttcaaacc ttccggtgaa atagcaaatg 49981 aaataataag taaaataaaa aaattggatg gttccaaggt ccaggagtat gtttacttta 50041 atgtaaacaa taccgattat atttccattg tcaaacccgt ttccgataaa aactcctttg 50101 gattgggctg gttgattatt tactcgagcc ttcaaaaagt caatcagcta aagctgggta 50161 taaatatgat acttattgtc attgtgcttt tatcggcgct gatttttgcc atattttctt 50221 ctcttgcggc aaaaaaaata tcagccccgt tttcctcttt aaatcagcat atcagggcca 50281 ttgccgaaag aaatttcggc gtgaaaatcg aaatgccggt ggatgcggaa cttcaagagc 50341 tggtaaacag cataaatatt atgtccgaaa aactggagtc ctatgataaa gcccagaaga 50401 cctttttcca aaatgcctcc catgagttca gaacccccct tatgtccatc caaagctatg 50461 cagaaggtat aaaatacgac gtggtggaca aaaataccgc cgcagatatt ataattgacg 50521 aaacaaaacg gatgacccac cttgtggaag atttgctgta cctttcgcgc cttgatacaa 50581 ttgaggaaaa ttatcgtttt gccgaccttg acttcaagga ttttataaat gcctgccagg 50641 aacgtatgta tggcatagcg tcaaaaagcg gcatcaatct tgaggttgaa aacataaatg 50701 aacccgttgt ggtatatgcc gacgaggaaa agctttttcg tgcttttgca aatatcattg 50761 gcaactgcat ccgatatgcc aacaataccg taagcattgt tccaaaaatt attgaccgct 50821 ccaaaattga aattgtcatc cgggatgacg gccccggaat agattccaat gaacttccca 50881 atatttttga aaggttttac aagggcaaaa aaggtaatgt gggactgggt cttgccatca 50941 gcaaaaacat aattgaaagg cataacggaa aaatcacggc ccgaaactca gaatccggtg 51001 cagtatttac cattgtgctt cctgtcaaac aatcctaaaa gtttcaggca aacataaatt 51061 cttgtttcat acggcttact tatttatcgt cgttacaaca atcctctttt ttctcttcaa 51121 caggatccat atgaacgact atatcaattc cgagctcatt ttttattctt tgctcaattt 51181 catcaattat tgaatgtatt tcaactatgt ccgccccttc aggcacttcg gcatgaatag 51241 acgcacttat cctgccggga ccgtaatcat gaactttcaa gtcatgagtg ccctttattt 51301 tttctccgac caaaaaatat gaatttatgc tctcgatgag ctcagagtta ggacacaagc 51361 ccagaagcag gtccaccgaa tctttcgcaa taccaaatcc tgtatacata atcagtgcgg 51421 atatgattaa acccataatt ccatccaggg gaaaagaaac aaaccttcca attagagttc 51481 ctgcaagcac tgcggttgtg gcaatggcat cgttcagact atcctgggct gtcgctttgt 51541 taattcccga attgattatt tttcctatat atctattgta tgaaaacatc cacaatttta 51601 cagccactga gataacgagc aataatatcg acattgtact caatgtcact tcttcaggtt 51661 tgattatttt ccaaaaagaa tttcttaaaa gttcaagacc aacaccaaat ataataaacg 51721 acaccacaag agatgatata tactcatacc ttccatggcc atgaggatgt tcctcgtccg 51781 gaggcctgtt gctaagcttg acaccgagta ttccaaccaa tgacgaacct aaatcgctta 51841 aattgttgaa agcgtcagaa attactgcaa tactgttcat gaccagtccc acagttattt 51901 ttacaataaa caaaaatacg ttgcaaataa tgcctgttac tcccgacaat actccgtaag 51961 cttcccttac ctttttgtta tccacatttt gataatcctt gataaaccac ctgattaaaa 52021 gtttaatcaa cgcaaggcct ccattccaaa cactaccgta ttcatcaaaa ttgtttccca 52081 catttagtat attcaacagg gtgcaaaaaa cacatctgcg gaatgacact tacccacaga 52141 tgtgcttgaa cacatttatt ttattgcgtt tttcatttta cgcacatatt cttcaacgta 52201 cggtatgcat tcggcaccgt attgggctat aatctttaca attgcacttc ctacaatcac 52261 tccgtcggag aaaccggcca tctgagcagc ctgctccgga gtggaaatac caaatccaac 52321 ggcacacgga atgtctctga cctcttttac aatttttatc atttctttgg catcatcacc 52381 gattttctct ctgacaccgg taacacccat ggacgacaca cagtaaataa agccttccgc 52441 ttccctggca atcattctga tgcgctcttt tgacgtgggt gctatcattg agataaatct 52501 gacatcatat tctttgcaga aaggagccag ttcttccttt tcctcaaaag gaatatcggg 52561 aacaataagg gcatcaattc ctgtttcgcc gcatcttttc aaaaactttt cacttccgta 52621 agtaaatatc ggattggcat atgtcataaa agcaataggt atatcgcagg atttacgtat 52681 gcgtcccacc atgtcaaaaa tcttgtccgt tgtagtaccc gccgaaaggg cacggtaatc 52741 tgcctcctga ataacaggtc cctccgccac cggatcggaa aacggtatgc cgagctcaat 52801 taaatccgcc ccggcttcag ccattctata caccaactgt tcggttatct ccagtgacgg 52861 atcgcccgcc gtaatgaacg gaataaatgc ctttccgttg ctaaacgccc gttctaattt 52921 attcatagat ttgaaccccc ctgtaacgcg ctatcgccgc aacatcttta tcgcctcttc 52981 ccgaaaggca aattacaatt atctgatctt tgctcatcgt cggagcaagt ttcattgcat 53041 atgcaaccgc atgggaactc tcaattgccg gaattatacc ttcggttcgg gaaaggtatt 53101 caaacgcctc aacggcctca tcatcggtaa cggctacgta ttgagccctt ccaatatcct 53161 tcagatacgc atgttccggg cccactcccg ggtagtccag acctgcggaa atagaataaa 53221 ccggtgcaat ctgtccatat tcatcctggc agaaataaga cttcatgccg tggaaaattc 53281 ccaatgtacc ttttgacatt gttgccgcat gcttgccggt ttccaaccct tttccggcag 53341 cctcgcatcc gataagccga acacttgaat caccaataaa ctcataaaac gctccgattg 53401 cattgctgcc tccgcccaca cacgccataa caacgtcagg aagttttcct tccttctcca 53461 taatctgctt tttaatttcc cggccgatta cgctctgaaa atcccttaca atggtaggaa 53521 acgggtgtgg tcccatgaca gaacccagca cataatgagt gtcatgaacc cttctcgacc 53581 actctctcaa agtctcattt accgcatctt taagtgtctg tgttccgctt gtcactgcat 53641 gaactttcgc gcccaaaagc tccatcctaa atacattcaa cgcctgacgc tcggtatcct 53701 ccttgcccat gaaaatttca cattccaatc ccataagcgc cgcagcggtt gccgtcgcaa 53761 caccatgctg tccggcgccg gtctcggcaa ttacgcgttt tttacccata cgttttgcaa 53821 gaagcacctg gcccaaaaca ttgtttattt tatgcgaacc tgtatggttg agatcctcac 53881 gtttcagata aatttttgct ccgttcaggt cttttgtcat cttttccgca taataaagta 53941 aagacggacg tcctgcataa tttttcaaca ggtcgtcaag ttccgccaaa aagtcggggt 54001 cgtttttaaa gtggttatat gcctcttcca gctcaatcac ggcgttcatc aatgtttccg 54061 gaatgtattg tccgccgtgg attccaaatc ttcctttcga catatacgtc accctccttc 54121 tgaaaaataa actatataaa taaaaaacgc ctttatccct cgacagggac aaaagctgtt 54181 cacttctgcg gtgccaccca cattggcgaa taaatcgccc actcattttt gtataccaac 54241 atatacaccc tgctgataac gggaagggca cccgtaagcg cctactcttt tttccaattt 54301 cgggcttccc tcacaagtcc attcagaata acctttgcaa ctgccttccc accaaccggc 54361 agctctcttt gtgcaagccg ttattcctac tactcttgct cataggttta tttatatata 54421 ctattacagt ttagtatatc actaaataac tgtttttgtc aacagcaaaa tttgacccct 54481 attttcaggt ttctatatca taatatccaa tatttttatc atttaacaaa tcagtatacc 54541 tgatacgctt tccctcaata ctgatctgat cagtataaac agaatctatt ttattgacgg 54601 tttcatcttc ttccttatac acactaagcc tgttaagagt atctatgtaa taaatatccc 54661 cgttatgata aacggcactt ctttctttca catccaatgc caatactgtt tctgaatttg 54721 tatttctgtc aattctaacc agtcttttgc cttgcagata atatatataa ttcgcattga 54781 gaaaaaaata atcaactgac ggcagactag tttgatcctg tcttctatcg aaaaatgctc 54841 caaaaaaatt tttatcattc tcttggatac cattataaat caattcctct ttaaaatctt 54901 ttaaatcaat accatatatt tgaaatccat cagtttgcaa tatttctttt aaataatagc 54961 accatccgtc tcttacaaat atcgacctta ttctgtatcc tcgttttaat gatctgtctt 55021 cagtttcata tatatcctgt ctgaaaggat cctttggcaa aacaatttgc tctcctttat 55081 caagattctc cgcagttatt atattttttt ccggatccaa agatattaca tactcatcag 55141 tttttacaca tctccattct tccgaagcat tgaaagtgaa attatctttt tcgctcattt 55201 ctgtccggca acctgtaaga attaaaagca gaatggttaa cacacataaa gcacatgaga 55261 acttacgtat tttattaccg aaattattta ggcgaaaagt atgccttgaa tatttcacaa 55321 tgcaagtcaa aaaaagaaat acaatttcaa ttacaaacat taacatcaat aaagtaatca 55381 tatttttact aattttttga aataatatta ttctatccac tccttcttca gtaatagccg 55441 aaagataatt atctccccac aaataccctg ctccgacaag aagccctgac ggcagtggaa 55501 gataatataa tgtagttgtt cctccatata ctatatacgg taaaaacacc aatgtactgc 55561 aagtaaacaa agcaacaatt gtttttttac ttattacact tacaactgaa ataaaagctg 55621 taaacagcac cgcaccaact atgcgaaata atacgattat gacaaaagct tgtcttaaag 55681 aaacatacca gtcactatat tcaaaaaatt tcaaactttg caatggaaat gtactattat 55741 caagtcccac cataaaatcc acgcaaatat attctgctac tgaaaacaaa atcactatgc 55801 cagcacttaa aacaaatgcg ctcagtagct ttacgattgc aaccttgtac tttcccctaa 55861 cactggatac aagcaatgaa tacatgccac tttcatattc attgcaaaac aatggtacca 55921 taacaattag caagcacact ataagcaata catccggcgc gtcatggctc agaagtgtct 55981 gccagcccct ccaatcaata atatatctga catccggagc ttctttcgcg tagtaatatt 56041 gattatatac caaattaaaa acatctgcgt tttttaagca ttcataatac tttttagatt 56101 tttcttcata ctccttaaaa ccaatctctc catttctttt tttgtgagac aagtcttcta 56161 ggtaagcctg tgcatttgtt acactatcat attcagcttt aatggacttt tctttttcct 56221 ccgtaagttt accttgatag aggtttatat agtatttata accttcttcg ttgctattga 56281 taatgctgtt agaatcatat ccctggtaaa ataacagggc aattttgaga agaaacataa 56341 tacctataca aagcaatcct ttttgtttta tcaggacttt cttccattca aaaactatca 56401 tcctatgaac tttcccttgt aattaatttt tttatcactc ttaaatctct gatagagact 56461 atcatataaa taagaataaa tatcattaac acaatgaaaa tttgaacaat taatgctaca 56521 tgtgccctta aataaaaagt atcccttatg tttattccca gcaattcatt aaacaactta 56581 tttgctctca ataatgtaaa cggactcata agcgcccata ttgtttttga ggtttcgaca 56641 gaagccacat acccactggc ataaatcccg agaactacac tcaaagtact tatcgcataa 56701 ggatagacaa ctcgttgaaa caaagcagaa aggaggcaaa tccaagtcgc aaacacaaac 56761 aaccccacca ctttcaatag tgtttgtaaa acataaaaca ttcccacaga acaattaaga 56821 ggcgtatatt ggtaagcctc taccgcatat atgggcattt gaatccctga aagtccatat 56881 aaaaatttac atactaaaaa gttaataccg gaaaaaacaa ttactaaaaa tgctgtgtac 56941 aaaaatatcg aaaatacttt tacaaaagtc atactaaatt ttccttttat acttgaaagt 57001 ataagcttgt ccatatttgt atttttctca tttacaaaca taggtgcaac ccctaaaagt 57061 aaaagtaaaa ctattagcaa atccgaaaaa tcatattcaa acagtaatcc ccaaaactta 57121 ccattatgaa aaacatctat tttccttcca ctataatgtt ttacaataaa ttcatttttg 57181 gatttgtcaa aattattgcc acattggctg taaaattcaa tgttggcctt tgcattctca 57241 attacctgtt taatcgcaga ttcatacgtt gaaacatact tcatgggtct ataaaaatac 57301 ttggttataa aaacataatc tccccaaatg tatcctgtat atgttccttc ctgtttctct 57361 ctgctataag tgccgtccgc gaccattgca tcaagccgtc tgtactcact aaccacaaat 57421 cttgccttgt cagccgttaa ttttcccgac actttatcat acatttcctg ataagactgc 57481 caccatttct gatattccgc agtatgcggc aaaaaatatc catacaaatc gttagggcca 57541 tataaataat ctttataaat tataagtata tttattaaca aaaaagacaa aagagctatt 57601 acaacataac ttcttaaata attttttctt atctcaaagt aaacaatcct tatcataaaa 57661 ccaaactcct gatttattgt tccattatcg ataaaaaaac atcttccaaa gaaggtgcca 57721 cagcttcggc aatcccatcc ggcctgcttt cggaaacaat gcgcagttgt aatttgtctt 57781 ccaatcgttt gatatttgca atcaaatact tatgcatata tttttctaca tctgtctctg 57841 acacagtcac attccatatt ttgccttcca cagttctttc taattctttt gtagtacctt 57901 ttttcactaa cttacctttt ttcagaatta atacttcttt tgcaatatat tcaacatctg 57961 aaacaatgtg tgtggccaaa agcacaatcc tgtctttgga aagctttgaa ataatatttc 58021 gaaaacgtat tctctcaccg ggatccaagc ctgcagtcgg ttcatccaaa atcaggatat 58081 ccggtctgtt aagaattgct tgtccaattc ccagtctttg tctcattcct cctgacaaag 58141 cacctacttt tttcttatat gagtcggtaa gatttactaa ttccagcacc tcttctatcc 58201 tgctatctac atgttttgac gggataccct taattgcgca catatatttc aaaaactcat 58261 ccactcggaa atttttataa aaagtcggtt cctgaggtaa atatccaact ttatccagat 58321 attttgtgcc catttttttt acgtcagacc catccagtaa aattgctcct ttactggcct 58381 ccaaaacccc aataattata tttatcagcg tagtttttcc cgccccgttg ggtcccagca 58441 atccatatat gccttccgta aaaacaccat taaaattatc caatgcgcac tgttttccat 58501 aaaacttggt tatattttca agcttaagtt ccatttcact cttccttaca attatattta 58561 caagaaatga cttctccgtt gtctttctga aacagaatta tacatgttga cggttcatct 58621 ctggtatata tctctatagg tatgcccatt tcaggagcca caatttcttc atggacaatt 58681 ttatcgcttt ttaatttata ctgccgtatg caatggcttc catcagaatt tgacttgatt 58741 gcaatcaggt attttccgtc atttgtagct atcgccatat tattttcttc tccatccaac 58801 tgcattttaa aatttttctt tgtctgcaaa tcaataccca gtaatctgcc actggagctt 58861 ttcattgggt ttctgtcttc ttcaaataca acatactttt gtgaaactct cattcttacg 58921 caattaaaat tcttctcagc aaaaacattc atctttttgc tttgaggttc aaacgctcca 58981 taataaaaag taccttcttc attcacccgt atgccgtaaa aaacaatatc atctccggca 59041 aacagcacac ttgaaaaaca tatattatta ctggtttcat taagaatctc gcttgttttg 59101 cctgtctcta catcatacat atatagtttg ggcgaagact ccgcccatat aattttttta 59161 ccatcccgcg aaacagtcat ttttgaaaca atcgtttgat gataattgtt tttttgtgga 59221 aatatatcca caaagtcaat ttccttttgt aaatttaagt ttttatcata aattttgaca 59281 agccttcgtt ttacatcctg aggaaaatct ataaatttaa aaccggattc ttctgtaagt 59341 tccacaggcc tgtcagcata agctgtgaca ataatataac ccttatcaaa ttcaagtgcc 59401 ttttcaataa aactgttttt ttcaatggta atctgcttta ccggtgaaga ttttccattt 59461 tccatcaata gcatataacc tgattcatag tcaacatcaa ggtatctcga ataatccttg 59521 tcctgagcaa gagtaccgga tttacttaaa tccaaatagt ttttgtgagc gctgttttta 59581 ttaccttgag attgtgtgct acttttcaaa tcattcacta aaagaatgga attcgttttt 59641 attggaaagt atatgtctgc aaaatagcct tttcctgatg gatttgatat tgcatatatg 59701 gtatttaatc tttcataatc actaatatcc agctccaaat caaaagtaca catttttcct 59761 ttttcaattt tagctgctaa atagtctgaa ttcataatcc gtacaggttt atggttaaca 59821 aaaatagtag tgttgtattc tatttcaggt ccaccatata tacgaaattt aaacttaact 59881 tttccatttt tagcataaat aacattctta cttttatcgt cataaattat ttccgtcctg 59941 gtcattgtgt ctatgtcatc gaatgcattt gcttcagacc cgacattact tttcagttct 60001 tcaggaatat cctcaagcac gtatttggaa tatccacgca gttctttctc attaacaaat 60061 tcagatttaa aatatatttc acttggcttg ttcgcggcta gcgaatgata tacaccatac 60121 acaggtctgt tttcatcctc cggtataaag tcaggtttta aaatggttgc cgaaatgaca 60181 ccaatcctat ctcctttttt ccctgcaaca ggtgtaaata caacatcaaa ttcttctctt 60241 tcattatatc ccaaagaaaa tttatgcata aattgttctt cagtgactgt accatttttt 60301 cgtctaattc tatacggttg aggaatccca tccacaaaaa acatcaaccc aaagtctgcc 60361 ttaacctttt cttccatacc ttccacataa tatggaatac agacttcttt cccattgtac 60421 tcataaactt cacgttcaga gaagttctca ctgataaatc caaaaccaaa ttgtgctatt 60481 gtctgactct tagtatcatt ctcattaaaa atatcctcaa tattttgatt atcttcctcc 60541 atcaattcgt ctttttgatt gtaattcttt tctctgctgt tgcatccaat gcatagaata 60601 gagaagcaaa taacaaacat ggctagaatg attctcttca taagtagtcc cccattacac 60661 ttttttgctg ctcttttaaa atttttcaac ataaacttag cggtataagt ttattactca 60721 taccactaag tttcgccgta catcaccttt atatagttgt ataagtatgt ctattttatt 60781 aaattaataa agtctttgcc gaaaacctta ccgtgcaatt ataattatgt aatttttatt 60841 ttttatctca tatctgcaac aaaaatctat taaaataatt tttcttttag ctatacaaat 60901 tgctaaaatg ttgtgcatgt atatctcaca atagcattct ttcctcttgc ttcatgacaa 60961 ccaaatgctg caaactcatg atgtggcaat atattggatt tagttaatgt tttggcagta 61021 ggtgcattgg tcttactatc aatacaagta tataacggtg tacctgtttt attgtcctgc 61081 acctcaattt ttactataac tgttgtgccg gctgaatact tagtaattga tgtaatacct 61141 tctactctga cattataagt tctggatata ggatgggtga cctcatgccc caaactccaa 61201 gaaaatgttc caaattcagg tgtttgccca cttccctcgt ttgcacctgc atttactaaa 61261 agaccggtca tacttatagt tacaattata caaataatta aagcagtaac tcttactttt 61321 ttcattattt ctcgtcaccc ctttaattgc taattaatgt tcaattatta caagaggtgt 61381 gtacgaacga tatatatatt gccattaagt aaactttatg ttaatatatt caattttaat 61441 taaatttatt taaagaatca aaaacaaaag aaataactcc gagatgatca aaaagaattt 61501 tgcaacccat tccaatcaaa ataagtccgc ctacaatttc agcttttgac tgaaacttta 61561 ctccaaataa attgccaatc tttacaccca gaaatgaaaa agtgaatgta gttatcccta 61621 tcatcgtaac tgccggaata atatttacct gcaaaaatgc aaaagtcact cctattgcca 61681 gagcgtcaat acttgtagca aaagccatca ccgtaagact cttaaggctg aatgtgtcat 61741 cttcgtcagt tatttcgcag gtatttttag attcctttat catattaatg ccaataagcg 61801 aaagcagacc aaaagcaatc caatggtcaa ttgaagttat ataatcttta aactgtgttc 61861 ccagaagata acccaaaaga ggcattaaag cctgaaatcc tccgaaaaaa cagccggtta 61921 aaaccgcatt cctgtaactc atttttttca ttgacaaacc tttgcagatt gcaaccgcaa 61981 aagcatccat tgaaagtcca accgcaataa tcagcagttc aatactactc attatttttt 62041 actccttcgt acgtcaattt gccgcgcaac aagcactgca taaacctcgc cgcgaaattt 62101 caataatatt tatactaaca taattttggc aaattgcata gagaattttc acagcatttt 62161 atatcaaatt ttatacaatt acttcaacgt ttatactaag ctgttatacg gtatttaaat 62221 acctgtcatt caattggcac tttactacta aaatagagta tgagataatt attttcgaag 62281 aaatgcaatt ttttagaaaa ggggtcgaac aatgaacaag aaacagctaa tcggtttaat 62341 tgtggcagga gtagtatttg tttttgtttg ttcttcaagt gttttggtaa acaccgtttc 62401 aaaaagactc ggaacgtctc tgaacttaag cgacagcgaa agcagtcttc ctcttactcc 62461 ctatataggt gttgtaagtg ttgaaggcac cattatggac agcaactcaa ccacaagttt 62521 cttaagcaac ggttacaacc acaaagaaac gttgaagctc attgaggata tgaaaaattc 62581 agcaagcaac aaaggcattc ttttgtatgt gaattccccc ggcggaggcg tttatgaaag 62641 tgatgaattg tatttgaagt tgaaagaata caaagaagaa accggaaggc cggtctggac 62701 ctatatgtca aatcaggcat gttccggtgg ctattatatt tctatggcat ccgacaaagt 62761 attttcaaac cgaaacgcat ggaccggttc catcggcgtc atcatctccc tgacaaacct 62821 caaaggcttg tacgataacc ttggaattaa aggtatttat attacaagcg gcagaaacaa 62881 agcaatgggt gctgccgatc tggaattgac agatgagcag cgtgatatac ttcaaagcct 62941 tgtggatgag gcatatgagc aatttgttga aattgtggcg gaaggcagaa aaatgacagt 63001 ggaagaagta aaaagaattg ccgatggaag aattctttcc gcaaaacagg cactcgagtt 63061 gaacctcatt gatgaaattg ccacgtatga tgaagtaaaa gaagctttca gcgcagagct 63121 tggaaatgtt aaaatatata cacccaaaaa gaaagacccg tttggactta gctctttgtt 63181 cagctatata aacagcttga aacctcgctc tgatactgaa ataatagccg agttgataaa 63241 ggctaaagga aatggggtgc cgatgtatta tgcaatgccg ggacaatact aatattattt 63301 acgcaggttt tggggcacga ctggcagcat atcttgttga ttctctgctg gtgggaattg 63361 ctctgctggt tgtaagaata ccgatgttta tagccaatat cattggaact ccggatttta 63421 ttacagcacc tatacttttt caatttaaca tcttcgacat tgtcatttat ttactgagta 63481 tactgtacta cactttaatg acatactact ccggctcgac actgggaaaa aaatttctca 63541 atcttaaagt gataagtgca aacggtgaga aactaacatt tatcaacgta ttatacagag 63601 aaacaatagg taaatacttg tccggaattg ctatgtttgt aggttatttc atgatagcag 63661 ttgatgaaca aaagcgggga cttcatgaca tactttgcga cacaagagtt atttacaatt 63721 tcaaagtacc tgttaaaaca gcggaaaaat atcccagtaa aaaatacgcg tggacatgga 63781 gtataaaaga ggaatttttg aaagatttcg tggaactgca tttaaaacct tcgccggaga 63841 tgctcgaaga gcaaaagaaa gcgggatata aaaactcttc tttctttaac aacggcaacc 63901 agttcttttt tgtatttgaa tgtgacaaca ttgattatgc caataattat ttatcttcaa 63961 gtcaagtctt ccgggagtgg tatgaaaccg tctctcccat ggtggagaat ccttttgact 64021 tgaaaaatgc cgtagctgtt t //