LOCUS NZ_ACVX01000037 34223 bp DNA linear CON 10-NOV-2010 DEFINITION Clostridium thermocellum DSM 2360 ctg00029, whole genome shotgun sequence. ACCESSION NZ_ACVX01000037 NZ_ACVX00000000 VERSION NZ_ACVX01000037.1 GI:256005688 DBLINK Project: 55637 KEYWORDS WGS. SOURCE Clostridium thermocellum DSM 2360 ORGANISM Clostridium thermocellum DSM 2360 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 34223) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE The draft genome of Clostridium thermocellum DSM 2360 JOURNAL Unpublished REFERENCE 2 (bases 1 to 34223) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Larimer,F., Land,M.L., Hauser,L. and Hemme,C.L. CONSRTM US DOE Joint Genome Institute (JGI-PGF) TITLE Direct Submission JOURNAL Submitted (17-JUL-2009) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from ACVX01000037. URL -- http://www.jgi.doe.gov JGI Project ID: 4085028 Source DNA and Bacteria available from Christopher L. Hemme (hemmecl@ou.edu) Contacts: Christopher L. Hemme (hemmecl@ou.edu) David Bruce (microbe@cuba.jgi-psf.org) Whole genome sequencing and draft assembly at JGI-PGF Annotation by JGI-ORNL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##Metadata-START## Organism Display Name :: Clostridium thermocellum DSM 2360 Culture Collection ID :: DSM 2360 GOLD Stamp ID :: Gi02594 Isolation Site :: contaminant of Clostridium thermocellum strain LQ8 Isolation Country :: USA Oxygen Requirement :: Anaerobe Cell Shape :: Rod-shaped Motility :: Motile Sporulation :: Sporulating Temperature Range :: Thermophile Temperature Optimum :: 60 C Gram Staining :: gram+ Biotic Relationship :: Free living Diseases :: None Phenotypes :: Cellulose degrader, Ethanogenic, Ethanol production Energy Source :: Chemoorganotroph ##Metadata-END## FEATURES Location/Qualifiers source 1..34223 /organism="Clostridium thermocellum DSM 2360" /mol_type="genomic DNA" /strain="DSM 2360" /isolation_source="contaminant of Clostridium thermocellum strain LQ8" /db_xref="taxon:572545" gene 482..4174 /locus_tag="ClothDRAFT_2506" CDS 482..4174 /locus_tag="ClothDRAFT_2506" /inference="protein motif:PFAM:PF00759" /note="PFAM: glycoside hydrolase family 9; glycoside hydrolase family 9 domain protein Ig domain protein; Carbohydrate-binding CenC domain protein; type 3a cellulose-binding domain protein; cellulosome protein dockerin type I; KEGG: scl:sce2234 cellulase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 9" /protein_id="ZP_05430645.1" /db_xref="GI:256005689" /db_xref="InterPro:IPR001701" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /db_xref="InterPro:IPR003305" /db_xref="InterPro:IPR004197" /translation="MKFRRSICTAVLLAVLLTLLVPTSVFALEDNSSTLPPYKNDLLY ERTFDEGLCYPWHTCEDSGGKCSFDVVDVPGQPGNKAFAVTVLDKGQNRWSVQMRHRG LTLEQGHTYRVRLKIWADASCKVYIKIGQMGEPYAEYWNNKWSPYTLTAGKVLEIDET FVMDKPTDDTCEFTFHLGGELAATPPYTVYLDDVSLYDPEYTKPVEYILPQPDVRVNQ VGYLPEGKKVATVVCNSTQPVKWQLKNAAGVVVLEGYTEPKGLDKDSQDYVHWLDFSD FATEGIGYYFELPTVNSPTNYSHPFDIRKDIYTQMKYDALAFFYHKRSGIPIEMPYAG GEQWTRPAGHIGIEPNKGDTNVPTWPQDDEYAGIPQKNYTKDVTGGWYDAGDHGKYVV NGGIAVWTLMNMYERAKIRGLDNWGPYRDGGMNIPEQNNGYPDILDEARWEIEFFKKM QVTEKEDPSIAGMVHHKIHDFRWTALGMLPHEDPQPRYLRPVSTAATLNFAATLAQSA RLWKDYDPTFAADCLEKAEIAWQAALKHPDIYAEYTPGSGGPGGGPYNDDYVGDEFYW AACELYVTTGKDEYKNYLMNSPHYLEMPAKMGENGGANGEDNGLWGCFTWGTTQGLGT ITLALVENGLPATDIQKARNNIAKAADRWLENIEEQGYRLPIKQAEDERGGYPWGSNS FILNQMIVMGYAYDFTGDSKYLDGMFDGISYLLGRNAMDQSYVTGYGERPLQNPHDRF WTPQTSKRFPAPPPGIISGGPNSRFEDPTINAAVKKDTPPQKCFIDHTDSWSTNEITV NWNAPFAWVTAYLDEQYTDSETDKVTIDSPVAGERFEAGKDINISATVKSKTPVSKVE FYNGDTLISSDTTAPYTAKITGAAVGAYNLKAVAVLSDGRRIESPVTPVLVKVIVKPT VKLTAPKSNVVAYGNEFLKITATASDSDGKISRVDFLVDGEVIGSDREAPYEYEWKAV EGNHEISVIAYDDDDAASTPDSVKIFVKQARDVKVQYLCENTQTSTQEIKGKFNIVNT GNRDYSLKDIVLRYYFTKEHNSQLQFICYYTPIGSGNLIPSFGGSGDEHYLQLEFKDV KLPAGGQTGEIQFVIRYADNSFHDQSNDYSFDPTIKAFQDYGKVTLYKNGELVWGTPP GGTEPEEPEEPEEPEEPAIVYGDCNDDGKVNSTDVAVMKRYLKKENVNINLDNADVNA DGKVNSTDFSILKRYVMKNIEELPYR" sig_peptide 482..565 /locus_tag="ClothDRAFT_2506" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 at residue 28" misc_feature 599..1015 /locus_tag="ClothDRAFT_2506" /note="Carbohydrate binding domain; Region: CBM_4_9; pfam02018" /db_xref="CDD:145283" misc_feature 1118..1390 /locus_tag="ClothDRAFT_2506" /note="Cellulase N-terminus domain. Cellulases are O-glycosyl hydrolases (GHs) that hydrolyze beta 1-4 glucosidic bonds in cellulose. They are usually catagorized into either exoglucanases which sequentially release sugar units from the cellulose chain and...; Region: Cellulase_N_term; cd02850" /db_xref="CDD:30337" misc_feature 1403..2908 /locus_tag="ClothDRAFT_2506" /note="Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959" /db_xref="CDD:186543" misc_feature 3500..3733 /locus_tag="ClothDRAFT_2506" /note="Cellulose binding domain; Region: CBM_3; pfam00942" /db_xref="CDD:109977" misc_feature 3986..4045 /locus_tag="ClothDRAFT_2506" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 4082..4144 /locus_tag="ClothDRAFT_2506" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene complement(4282..4893) /locus_tag="ClothDRAFT_2507" CDS complement(4282..4893) /locus_tag="ClothDRAFT_2507" /inference="protein motif:PFAM:PF05067" /note="PFAM: manganese containing catalase; KEGG: sml:Smlt2537 putative managnese containing catalase" /codon_start=1 /transl_table=11 /product="manganese containing catalase" /protein_id="ZP_05430646.1" /db_xref="GI:256005690" /db_xref="InterPro:IPR007760" /translation="MWVYEKKLEYPVKIKNPNPKLAKYIISQYGGPDGELAASLRYLS QRFSMPTNEAKGILNDIGTEELAHLEMIGTIVYQLTRGVPADVLERVGLGAYYTDHDH AVYPMSASGTPFTAAYIQSKGDPIADLHEDMAAEQKARATYENLINLTDDPDVIDPLR FLREREVVHFQRFGEALRIVQDKLAEKPFYVKKPDCMNPAYKR" misc_feature complement(4351..4893) /locus_tag="ClothDRAFT_2507" /note="Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051" /db_xref="CDD:153110" misc_feature complement(order(4387..4389,4486..4488,4690..4692, 4699..4701,4789..4791)) /locus_tag="ClothDRAFT_2507" /note="dimanganese center; other site" /db_xref="CDD:153110" gene complement(4956..5201) /locus_tag="ClothDRAFT_2508" CDS complement(4956..5201) /locus_tag="ClothDRAFT_2508" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430647.1" /db_xref="GI:256005691" /translation="MNPNQAQLLKEVMAADFTLIDLNLYLNTHPYDQNAIMLFYNCAQ RAKILRNEYERLYGPLTAQSTPYKCPWQWINSPWPWE" gene complement(5214..5471) /locus_tag="ClothDRAFT_2509" CDS complement(5214..5471) /locus_tag="ClothDRAFT_2509" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430648.1" /db_xref="GI:256005692" /translation="MMEYPSYNPGMLQPVHGQGMMQPCHTQSMSHNVKIHCMPMKLAH AYVPFQHMSCIFPPVKGLNAGTIFPELYSPYGKDPEYTVDA" gene 5746..6009 /locus_tag="ClothDRAFT_2510" CDS 5746..6009 /locus_tag="ClothDRAFT_2510" /inference="protein motif:TFAM:TIGR00952" /note="TIGRFAM: ribosomal protein S15; PFAM: ribosomal protein S15; KEGG: gur:Gura_1905 30S ribosomal protein S15" /codon_start=1 /transl_table=11 /product="ribosomal protein S15" /protein_id="ZP_05430649.1" /db_xref="GI:256005693" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /translation="MQKELKQEIINKFKLHETDTGSPEVQIALLTERINHLTEHLKVH KKDYHSRRGLLKMVGHRRGLLNYLMKTDIARYRAIVEKLNLRK" misc_feature 5761..5997 /locus_tag="ClothDRAFT_2510" /note="Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353" /db_xref="CDD:48353" misc_feature order(5761..5763,5812..5814,5821..5823,5842..5844, 5854..5856,5863..5865,5875..5877,5881..5886,5890..5895, 5932..5934,5944..5946) /locus_tag="ClothDRAFT_2510" /note="16S/18S rRNA binding site; other site" /db_xref="CDD:48353" misc_feature order(5827..5829,5836..5841,5848..5850,5857..5859, 5977..5979,5989..5991) /locus_tag="ClothDRAFT_2510" /note="S13e-L30e interaction site; other site" /db_xref="CDD:48353" misc_feature order(5917..5919,5929..5931,5992..5997) /locus_tag="ClothDRAFT_2510" /note="25S rRNA binding site; other site" /db_xref="CDD:48353" gene 6245..8347 /locus_tag="ClothDRAFT_2511" CDS 6245..8347 /locus_tag="ClothDRAFT_2511" /EC_number="2.7.7.8" /inference="protein motif:PRIAM:2.7.7.8" /note="KEGG: sfu:Sfum_1234 polyribonucleotide nucleotidyltransferase; PFAM: 3' exoribonuclease; RNA binding S1 domain protein; Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type; Exoribonuclease, phosphorolytic domain 2; KH type 1 domain protein; SMART: RNA binding S1 domain protein; KH domain protein" /codon_start=1 /transl_table=11 /product="Polyribonucleotide nucleotidyltransferase" /protein_id="ZP_05430650.1" /db_xref="GI:256005694" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /translation="MYKTFSMELAGRTLTIETGKLAQLANGSVLVRYGDTVVLSTATA SATPREGVDFFPLSVDYEERLYAVGKIPGGFIKREGKPSEKAILTARVIDRPLRPLFP KDLRNDVAIVNTVLSVDQDNSPELAALLGSSIAVSISDIPFNGPVGAVILGLIDGEVI INPTEKQREISQMYVTLAGTRNKIVMIEAGANEVPDEVMLDAIKKGHEEIKKIVDFID GIVKEVGKPKFEYESAEVPEEIFNAVREYAYDKMREAVLAVDKQVRDKNIDDLTKEIT EHFAEVFPEMEPAIKEAIYKLEKKVVREYILEEGRRVDGRRLDEIRPLSAEVGLLPRV HGSGLFTRGQTQVLSSVTLGAMGDVQILDGIDTEETKRYMHHYNFPGFSVGEAKSSRG PGRREIGHGALAERALEPVIPSEEEFPYTIRVVSEVLMSNGSTSQGSVCGSTLALMDA GVPIKKPVAGISAGLVVDENNPDRFVTFMDIQGIEDFFGDMDFKVAGTKDGITAIQVD IKIDGLTEEIIKQAFELTRKGRLYIIDNVLLKAIPEPRKQMSKYAPKIISTTINPDKI REVIGPGGKMINKIIDETGVKIDINDDGRVYIFSSDIQAGKRARSMIEAIAKDIEPGQ VFLGRVIRVTSFGAFVEFLPGKEGLVHISKLDKKRVERVEDIVRVGDQILVKVIEIDK QGRVNLSRKDAMEDEWDK" misc_feature 6245..8326 /locus_tag="ClothDRAFT_2511" /note="polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824" /db_xref="CDD:183327" misc_feature 6275..6670 /locus_tag="ClothDRAFT_2511" /note="3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138" /db_xref="CDD:144653" misc_feature 6677..6871 /locus_tag="ClothDRAFT_2511" /note="3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725" /db_xref="CDD:146389" misc_feature 6959..7195 /locus_tag="ClothDRAFT_2511" /note="Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726" /db_xref="CDD:146390" misc_feature 7202..7603 /locus_tag="ClothDRAFT_2511" /note="3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138" /db_xref="CDD:144653" misc_feature 7904..8086 /locus_tag="ClothDRAFT_2511" /note="Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393" /db_xref="CDD:29003" misc_feature order(7934..7936,7940..7948,7952..7966,7973..7978, 7985..7990,8003..8014) /locus_tag="ClothDRAFT_2511" /note="putative nucleic acid binding region; other site" /db_xref="CDD:29003" misc_feature 7955..7966 /locus_tag="ClothDRAFT_2511" /note="G-X-X-G motif; other site" /db_xref="CDD:29003" misc_feature 8111..8314 /locus_tag="ClothDRAFT_2511" /note="S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472" /db_xref="CDD:88437" misc_feature order(8135..8137,8159..8161,8189..8191,8195..8197) /locus_tag="ClothDRAFT_2511" /note="RNA binding site; other site" /db_xref="CDD:88437" misc_feature 8252..8257 /locus_tag="ClothDRAFT_2511" /note="domain interface; other site" /db_xref="CDD:88437" gene 8479..9738 /locus_tag="ClothDRAFT_2512" CDS 8479..9738 /locus_tag="ClothDRAFT_2512" /inference="protein motif:PFAM:PF00675" /note="PFAM: peptidase M16 domain protein; KEGG: geo:Geob_2698 processing peptidase" /codon_start=1 /transl_table=11 /product="peptidase M16 domain protein" /protein_id="ZP_05430651.1" /db_xref="GI:256005695" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011765" /translation="MYKRIKLENGVRVVCEKIPYLRSVSIGIWVGTGSRNESQSNNGI SHFIEHMLFKGTDNRSAREIADSIDSIGGQLNAFTGKECTCYYTKTLDSHADIALDVL SDMFFNSRFEEKDIEVEKKVILEEIGMYEDSPEELVHDILSETVWEDNSLGLPILGTR ETLLNINKDKIKAYINERYLPQNTVIAVAGNFEEDRIIDVIKEKFGGWNASGKDSKTI EDAKFKVNSKIKVKDTEQIHICMGFEGVAHGSDELYPLLAVNNVLGGGMSSRMFQKIR EEKGLVYSIYSYPSSYKNAGLFTIYAGMNAEHLEKVVELIIKEIKILLKEGLSKDELE KSKEQLKGSYILGLESTSSRMNSMGKSEVLMDRIYTPDEILKKIDAVNQESVERVIKQ IFCLDKISFAIVGNIKKEIDIRKIINA" misc_feature 8479..9720 /locus_tag="ClothDRAFT_2512" /note="Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612" /db_xref="CDD:30957" misc_feature 8512..8958 /locus_tag="ClothDRAFT_2512" /note="Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675" /db_xref="CDD:144319" misc_feature 8971..9498 /locus_tag="ClothDRAFT_2512" /note="Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193" /db_xref="CDD:147402" gene 9942..10814 /locus_tag="ClothDRAFT_2513" CDS 9942..10814 /locus_tag="ClothDRAFT_2513" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: rpd:RPD_2299 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430652.1" /db_xref="GI:256005696" /translation="MKNKKFTIIGGDLRSVKLAELIVAEGNKVNIYGFKNANFEIGIE ESEDLDHAIGEADVIVGPTPCSTDNETINTPFHSQKIFIKDIFKKMNKSQLFIAGRIT DKIAQLADVYNVYSVDLLEREEMAVLNAIPTAEGAIQIAMEEMPITLHGSNALILGFG RIGKILAKMLHGIGSNVYVEARKYSDLAWIESYGYKPVFITELESYIDRANVIFNTIP SIVLDENLLRKVNKDCLLIDLASKPGGIDFEKAKEMGLKTIWALSLPGKVAPVTAAKF IKDTISNIIDELGV" misc_feature 9945..10811 /locus_tag="ClothDRAFT_2513" /note="dipicolinate synthase subunit A; Reviewed; Region: PRK08306" /db_xref="CDD:181371" misc_feature <10350..10661 /locus_tag="ClothDRAFT_2513" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" misc_feature order(10419..10427,10482..10487,10587..10592,10656..10658) /locus_tag="ClothDRAFT_2513" /note="NAD(P) binding pocket; other site" /db_xref="CDD:133449" gene 10819..11403 /locus_tag="ClothDRAFT_2514" CDS 10819..11403 /locus_tag="ClothDRAFT_2514" /inference="protein motif:TFAM:TIGR02852" /note="TIGRFAM: dipicolinic acid synthetase, B subunit; PFAM: flavoprotein; KEGG: cco:CCC13826_1269 3-octaprenyl-4-hydroxybenzoate carboxy-lyase" /codon_start=1 /transl_table=11 /product="dipicolinic acid synthetase, B subunit" /protein_id="ZP_05430653.1" /db_xref="GI:256005697" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /translation="MLLEGIKIGFGLTGSFCTIDKVIPEIEKLVSNGAKVFPILSGSV SKFDTRFGRAEDLRLKLEGITGNKVIDSIVDAEPIGPKSLLDIMVVAPCTGNTLAKIA NGITDTTVTMACKAHLRNQKPVVLSISTNDGLGANAKNIGLLLNMKNIYLVPFGQDGP GTKPNSLVADTTQIMPTILEALNHKQIQPILIKY" misc_feature 10819..11400 /locus_tag="ClothDRAFT_2514" /note="Flavoprotein; Region: Flavoprotein; cl08021" /db_xref="CDD:186735" gene 11720..12403 /locus_tag="ClothDRAFT_2515" CDS 11720..12403 /locus_tag="ClothDRAFT_2515" /inference="protein motif:PFAM:PF02629" /note="PFAM: CoA-binding domain protein; Rex DNA-binding domain protein; KEGG: pca:Pcar_1593 redox-sensing transcriptional repressor Rex" /codon_start=1 /transl_table=11 /product="CoA-binding domain protein" /protein_id="ZP_05430654.1" /db_xref="GI:256005698" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /translation="MNNPKAISKQTLLRLPSYLSYLKSLPKQDGEYVSATMIASALGL NDVQVRKDLACVSKKSRPKLGYVAEELIRDIESFLGYDSLNDAIIVGAGRLGGALLSY EGFKEYGLNIVAAFDVDESKIGTEICGRKIFPLDKMKELCRRMKIRIGIITVPADSAQ KVCDMLVDSGIYAIWNFAPVHLKVPDNILVQQENMAASLAVLSAHLAEAIKNNGIGKG DKENDENSE" misc_feature 11720..12304 /locus_tag="ClothDRAFT_2515" /note="redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472" /db_xref="CDD:180107" misc_feature 11963..12259 /locus_tag="ClothDRAFT_2515" /note="Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931" /db_xref="CDD:186874" gene 12384..15005 /locus_tag="ClothDRAFT_2516" CDS 12384..15005 /locus_tag="ClothDRAFT_2516" /inference="protein motif:PFAM:PF00465" /note="PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: shl:Shal_2250 bifunctional acetaldehyde-CoA/alcohol dehydrogenase" /codon_start=1 /transl_table=11 /product="iron-containing alcohol dehydrogenase" /protein_id="ZP_05430655.1" /db_xref="GI:256005699" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR015590" /translation="MTKIANKYEVIDNVEKLEKALKRLREAQSVYATYTQEQVDKIFF EAAMAANKMRIPLAKMAVEETGMGVVEDKVIKNHYASEYIYNAYKNTKTCGVIEEDPA FGIKKIAEPLGVIAAVIPTTNPTSTAIFKTLIALKTRNAIIISPHPRAKNSTIEAAKI VLEAAVKAGAPEGIIGWIDVPSLELTNLVMREADVILATGGPGLVKAAYSSGKPAIGV GAGNTPAIIDDSADIVLAVNSIIHSKTFDNGMICASEQSVIVLDGVYKEVKKEFEKRG CYFLNEDETEKVRKTIIINGALNAKIVGQKAHTIANLAGFEVPETTKILIGEVTSVDI SEEFAHEKLCPVLAMYRAKDFDDALDKAERLVADGGFGHTSSLYIDTVTQKEKLQKFS ERMKTCRILVNTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVSDNVGVKHLLNIKTV AERRENMLWFRTPEKIYIKRGCLPVALDELKNVMGKKKAFIVTDNFLYNNGYTKPITD KLDEMGIVHKTFFDVSPDPSLASAKAGAAEMLAFQPDTIIAVGGGSAMDAAKIMWVMY EHPEVDFMDMAMRFMDIRKRVYTFPKMGQKAYFIAIPTSAGTGSEVTPFAVITDEKTG IKYPLADYELLPDMAIVDADMMMNAPKGLTAASGIDALTHALEAYVSMLATDYTDSLA LRAIKMIFEYLPRAYENGASDPVAREKMANAATIAGMAFANAFLGVCHSMAHKLGAFY HLPHGVANALMINEVIRFNSSEAPTKMGTFPQYDHPRTLERYAEIADYIGLKGKNNEE KVENLIKAIDELKEKVGIRKTIKDYDIDEKEFLDRLDEMVEQAFDDQCTGTNPRYPLM NEIRQMYLNAYYGGAKK" misc_feature 12396..14984 /locus_tag="ClothDRAFT_2516" /note="bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805" /db_xref="CDD:184338" misc_feature 12432..13742 /locus_tag="ClothDRAFT_2516" /note="Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122" /db_xref="CDD:143440" misc_feature 13137..13139 /locus_tag="ClothDRAFT_2516" /note="putative catalytic cysteine; other site" /db_xref="CDD:143440" misc_feature 13770..14975 /locus_tag="ClothDRAFT_2516" /note="C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178" /db_xref="CDD:173937" misc_feature order(13863..13865,14037..14045,14052..14054,14061..14063, 14193..14198,14202..14204,14259..14264,14316..14318, 14340..14342,14361..14363,14373..14375,14571..14573, 14583..14585,14613..14615) /locus_tag="ClothDRAFT_2516" /note="putative active site; other site" /db_xref="CDD:173937" misc_feature order(14361..14363,14373..14375,14571..14573,14613..14615) /locus_tag="ClothDRAFT_2516" /note="metal-binding site" /db_xref="CDD:173937" gene 15002..15382 /locus_tag="ClothDRAFT_2517" CDS 15002..15382 /locus_tag="ClothDRAFT_2517" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430656.1" /db_xref="GI:256005700" /translation="MKLEKVIAVRTDKTVYRDGDKAIKVFSSNYSKANVLNEALNQAR VEETGLNIPKLLEVTKIDGKWAIVTEFIEGKTLEQLMKENPLKYDEYMNLFVDIQLEV LSKRAPLLNKLKDKMHRKNLRERS" misc_feature 15053..>15256 /locus_tag="ClothDRAFT_2517" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:186871" misc_feature order(15065..15067,15071..15073,15158..15160,15206..15217) /locus_tag="ClothDRAFT_2517" /note="ATP binding site; other site" /db_xref="CDD:88612" gene 15423..15752 /locus_tag="ClothDRAFT_2518" CDS 15423..15752 /locus_tag="ClothDRAFT_2518" /inference="similar to AA sequence:KEGG:RL3115" /note="KEGG: rle:RL3115 putative phosphotransferase family protein" /codon_start=1 /transl_table=11 /product="putative phosphotransferase family protein" /protein_id="ZP_05430657.1" /db_xref="GI:256005701" /translation="MPDHNKVCHGDFNPSNIIITKDGTPYILDWSHVTQGNASADAAR TYLLFWLSGDIDKAAKYLNLFCKKSDTAKQYVQKWISIVAASQLVKGREAERELLMRW IDVVDYE" misc_feature <15432..15713 /locus_tag="ClothDRAFT_2518" /note="RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]; Region: COG0478" /db_xref="CDD:30826" misc_feature <15441..15578 /locus_tag="ClothDRAFT_2518" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:186871" misc_feature order(15453..15455,15564..15566) /locus_tag="ClothDRAFT_2518" /note="substrate binding site; other site" /db_xref="CDD:88612" gene 15765..16010 /locus_tag="ClothDRAFT_2519" CDS 15765..16010 /locus_tag="ClothDRAFT_2519" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: pca:Pcar_1832 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430658.1" /db_xref="GI:256005702" /translation="MKVSICIGSSCHLKGAKQIVEQLQSLVADYNLKEKVELGGAFCM KNCVNGVSVTVDDKLFSVTPENVKSFFETEILKKLED" misc_feature 15765..15980 /locus_tag="ClothDRAFT_2519" /note="Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980" /db_xref="CDD:48529" misc_feature order(15768..15770,15774..15776,15882..15890) /locus_tag="ClothDRAFT_2519" /note="dimer interface; other site" /db_xref="CDD:48529" misc_feature order(15780..15782,15795..15797,15891..15893,15903..15905) /locus_tag="ClothDRAFT_2519" /note="[2Fe-2S] cluster binding site; other site" /db_xref="CDD:48529" gene 16063..17733 /locus_tag="ClothDRAFT_2520" CDS 16063..17733 /locus_tag="ClothDRAFT_2520" /inference="protein motif:PFAM:PF04060" /note="PFAM: Fe-S cluster domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SMART: PAS domain containing protein; KEGG: sfu:Sfum_1846 putative PAS/PAC sensor protein" /codon_start=1 /transl_table=11 /product="putative PAS/PAC sensor protein" /protein_id="ZP_05430659.1" /db_xref="GI:256005703" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001450" /db_xref="InterPro:IPR007202" /db_xref="InterPro:IPR017900" /translation="MTECLQTKKSNCKNCYKCIRHCPVKSLKFTDGQAHIVRDECVLC GECYVVCPQNAKQIRSDVEKAKQLVLKYDVYASIAPSFVAWFHNKSIHDMEQALIKLG FKGADETAKGAYIVKKQYEKMIEEKKSKIIISSCCHTVNTLIQRHYTGAIQYLADVVS PMLAHAQMLKKEHKGAKVVFIGPCISKKDEAEKYKGYVELVLTFDELDEWLKSENITI ESNRGSSKEGRTRSFPVSGGIISSMDKDLGYHYMVVDGMENCINALENIERGEIDNCF IEMSACRGSCINGPPARRKSNNIVGAILAVNKNTGAKDFSVPMPEPEKLKKEFRFEGV HKIMPGGTAIEEILKKMGKTSIEHELNCGSCGYDTCRDKAVAVLNGKADLTMCLPYLK EKAESFSDAIIKNTPNGVIVLNEDLEIQQINNSAKRILNLSPSTDLLGSPVSRILDPI DYILALREGKNCYYKRKYFAEYKKYVDETIIYDKEYHVIIIIMRDVTEEEKIKALKNK QSEAAIEIADKVVEKQMRVVQEIALLLGETAAETKIALTKLKETMEDE" misc_feature <16081..16227 /locus_tag="ClothDRAFT_2520" /note="ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163" /db_xref="CDD:162737" misc_feature 16282..16932 /locus_tag="ClothDRAFT_2520" /note="Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906" /db_xref="CDD:145848" misc_feature 17140..17229 /locus_tag="ClothDRAFT_2520" /note="Putative Fe-S cluster; Region: FeS; pfam04060" /db_xref="CDD:112857" misc_feature 17230..>17610 /locus_tag="ClothDRAFT_2520" /note="Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887" /db_xref="CDD:33676" misc_feature 17263..17418 /locus_tag="ClothDRAFT_2520" /note="PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459" /db_xref="CDD:141436" gene 17726..18895 /locus_tag="ClothDRAFT_2521" CDS 17726..18895 /locus_tag="ClothDRAFT_2521" /inference="protein motif:PFAM:PF07228" /note="PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: pca:Pcar_0518 hypothetical protein" /codon_start=1 /transl_table=11 /product="protein serine/threonine phosphatase" /protein_id="ZP_05430660.1" /db_xref="GI:256005704" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR010822" /translation="MNDLCVDLGYKSLNKFGEQLCGDMIQVVKDDDTTILVLADGLGS GVKANILSTLTSKIISTMIAAHMGIEECVNTIMSTLPVCKVRGIAYSTFTIIKITNNT YAEIIQYDNPLVILLRNGKKYDYPTQTKIISGKKIVESKIRLNCDDVFVAMSDGAIYA GVGQTLNYGWQRENIIEFIESHYDKSLSANALTSLLIDTCNNLYANMPGDDTTIAAIK IRKRQVVNLMFGPPQNPEDVHNMMSLFFAKQGRHIVCGGTTSTLAAKFLGKELETTID YIDPRIPPIARIEGVDLVTEGVLTISRVLEYAKDYIGKNILYNEWHSKNDGASIIARM LFEEATDINFYVGKAINPAHQNPNLPIGFNIKMQLVEELSKILKQMGKTINLSYF" misc_feature 17813..18385 /locus_tag="ClothDRAFT_2521" /note="Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120" /db_xref="CDD:185796" gene 18907..19404 /locus_tag="ClothDRAFT_2522" CDS 18907..19404 /locus_tag="ClothDRAFT_2522" /inference="protein motif:PFAM:PF01257" /note="PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: ppd:Ppro_1488 NADH dehydrogenase (ubiquinone), 24 kDa subunit" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase (ubiquinone) 24 kDa subunit" /protein_id="ZP_05430661.1" /db_xref="GI:256005705" /db_xref="InterPro:IPR002023" /translation="MSVTMSEAFDYSMIDNILSEHGTSETAIIAILQSIQEEYHYIPK EVFPYLSKKLKVSEARIFSVATFYENFSLEPKGKYIIKVCDGTACHVRKSIPIIERLR KELGLSGTKPTTDDLMFTVETVSCLGACGLAPVITVNDKVYAEMTPDKASELIKQLRE GDADA" misc_feature 18946..19383 /locus_tag="ClothDRAFT_2522" /note="NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958" /db_xref="CDD:131013" misc_feature 19138..19380 /locus_tag="ClothDRAFT_2522" /note="TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064" /db_xref="CDD:48613" misc_feature order(19144..19146,19150..19152,19273..19281) /locus_tag="ClothDRAFT_2522" /note="putative dimer interface; other site" /db_xref="CDD:48613" misc_feature order(19156..19158,19171..19173,19282..19284,19294..19296) /locus_tag="ClothDRAFT_2522" /note="[2Fe-2S] cluster binding site; other site" /db_xref="CDD:48613" gene 19397..21271 /locus_tag="ClothDRAFT_2523" CDS 19397..21271 /locus_tag="ClothDRAFT_2523" /EC_number="1.6.99.5" /inference="protein motif:PRIAM:1.6.99.5" /note="PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dat:HRM2_16600 NuoF" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase (quinone)" /protein_id="ZP_05430662.1" /db_xref="GI:256005706" /db_xref="InterPro:IPR001450" /db_xref="InterPro:IPR001949" /db_xref="InterPro:IPR011538" /db_xref="InterPro:IPR017900" /translation="MLKNREELRKAREMYSRYLKAEKRRVLVCAGTGCVSGGSMEIFE RLSELVSKRGMDCQVELKEEPHDNTIGMKKSGCHGFCEMGPLVRIEPEGYLYTKVKLE DCEEIVDRTIVAGEHIERLAYKQNGVVYKKQDEIPFYKKQTRLVLEHCGQIDSTSITE YLATGGYYALEKALFDMTGDEIINEITEANLRGRGGGGFPAGRKWAQVKRQNAKQKYV VCNGDEGDPGAFMDRSIMEGDPHRMIEGMIIAGIACGASEGYIYVRAEYPLAVSRLKR AIEQAKEFGLLGENILGSNFSFNIHINRGAGAFVCGEGSALTASIEGKRGMPRVKPPR TVEQGLFDMPTVLNNVETFANVPLIIKNGADWYKSIGTEKSPGTKAFALTGNIENTGL IEIPMGTTLREVIFDIGGGMRNGADFKAVQIGGPSGGCLSEKDLDLPLDFDSLKKAGA MIGSGGLVVMDSNTCMVEVARFFMNFTQNESCGKCVPCREGTKRMLEILERIVEGNGQ DGDIELLLELADTISATALCGLGKAAAFPVVSTIKNFREEYEAHIYDKRCPTGNCQKL KTITIDASLCKGCSKCARSCPVGAITGKVKEPFVIDQSKCIKCGACIETCAFHAILEG " misc_feature 19466..19729 /locus_tag="ClothDRAFT_2523" /note="Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980" /db_xref="CDD:48529" misc_feature order(19469..19471,19475..19477,19616..19624) /locus_tag="ClothDRAFT_2523" /note="dimer interface; other site" /db_xref="CDD:48529" misc_feature order(19481..19483,19496..19498,19625..19627,19637..19639) /locus_tag="ClothDRAFT_2523" /note="[2Fe-2S] cluster binding site; other site" /db_xref="CDD:48529" misc_feature 19796..21055 /locus_tag="ClothDRAFT_2523" /note="NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894" /db_xref="CDD:32078" misc_feature 19952..20467 /locus_tag="ClothDRAFT_2523" /note="Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512" /db_xref="CDD:144926" misc_feature 20543..20689 /locus_tag="ClothDRAFT_2523" /note="endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430" /db_xref="CDD:187036" misc_feature 20795..20932 /locus_tag="ClothDRAFT_2523" /note="NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589" /db_xref="CDD:151119" misc_feature <20864..21268 /locus_tag="ClothDRAFT_2523" /note="Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231" /db_xref="CDD:33956" misc_feature 21101..21172 /locus_tag="ClothDRAFT_2523" /note="4Fe-4S binding domain; Region: Fer4; pfam00037" /db_xref="CDD:143826" gene 21276..22976 /locus_tag="ClothDRAFT_2524" CDS 21276..22976 /locus_tag="ClothDRAFT_2524" /inference="protein motif:TFAM:TIGR02512" /note="TIGRFAM: hydrogenase, Fe-only; PFAM: hydrogenase large subunit domain protein; iron hydrogenase small subunit; 4Fe-4S ferredoxin iron-sulfur binding domain protein; ferredoxin; KEGG: ppd:Ppro_1490 hydrogenases, Fe-only" /codon_start=1 /transl_table=11 /product="hydrogenase, Fe-only" /protein_id="ZP_05430663.1" /db_xref="GI:256005707" /db_xref="InterPro:IPR000283" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR001450" /db_xref="InterPro:IPR003149" /db_xref="InterPro:IPR004108" /db_xref="InterPro:IPR013352" /db_xref="InterPro:IPR017900" /translation="MDNREYMLIDGIPVEINGEKNLLELIRKAGIKLPTFCYHSELSV YGACRMCMVENEWGGLDAACSTPPRAGMSIKTNTERLQKYRKMILELLLANHCRDCTT CNNNGKCKLQDLAMRYNISHIRFPNTASNPDVDDSSLCITRDRSKCILCGDCVRVCNE VQNVGAIDFAYRGSKMTISTVFDKPIFESNCVGCGQCALACPTGAIVVKDDTQKVWKE IYDKNTRVSVQIAPAVRVALGKELGLNDGENAIGKIVAALRRMGFDDIFDTSTGADLT VLEESAELLRRIREGKNDMPLFTSCCPAWVNYCEKFYPELLPHVSTCRSPMQMFASII KEEYSTSSKRLVHVAVMPCTAKKFEAARKEFKVNGVPNVDYVLTTQELVRMIKESGIV FSELEPEAIDMPFGTYTGAGVIFGVSGGVTEAVLRRVVSDKSPTSFRSLAYTGVRGMN GVKEASVMYGDRKLKVAVVSGLKNAGDLIERIKAGEHYDLVEVMACPGGCINGGGQPF VQSEEREKRGKGLYSADKLCNIKSSEENPLMMTLYKGILKGRVHELLHVDYASKKEAK " misc_feature 21303..21500 /locus_tag="ClothDRAFT_2524" /note="2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207" /db_xref="CDD:29262" misc_feature order(21372..21377,21384..21386,21411..21413,21417..21428, 21462..21467) /locus_tag="ClothDRAFT_2524" /note="catalytic loop; other site" /db_xref="CDD:29262" misc_feature order(21384..21386,21417..21419,21426..21428,21465..21467) /locus_tag="ClothDRAFT_2524" /note="iron binding site; other site" /db_xref="CDD:29262" misc_feature 21528..21650 /locus_tag="ClothDRAFT_2524" /note="NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588" /db_xref="CDD:151118" misc_feature 21696..22796 /locus_tag="ClothDRAFT_2524" /note="hydrogenases, Fe-only; Region: Fe_only_hydrog; TIGR02512" /db_xref="CDD:162896" misc_feature <21711..>21974 /locus_tag="ClothDRAFT_2524" /note="The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655" /db_xref="CDD:187409" misc_feature 22809..22964 /locus_tag="ClothDRAFT_2524" /note="Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256" /db_xref="CDD:145420" gene 22978..23223 /locus_tag="ClothDRAFT_2525" CDS 22978..23223 /locus_tag="ClothDRAFT_2525" /inference="similar to AA sequence:KEGG:SYN_01648" /note="KEGG: sat:SYN_01648 NADH:ubiquinone oxidoreductase, NADH-binding subunit" /codon_start=1 /transl_table=11 /product="NADH:ubiquinone oxidoreductase, NADH-binding subunit" /protein_id="ZP_05430664.1" /db_xref="GI:256005708" /translation="MLEIKICVGSSCHLKGSYNVINEFQHLIEEKALHDKIDIKATFC MKQCQKNGVAVEVNNEIFGVLPEAAEEFFKNVILPKV" misc_feature 22987..23199 /locus_tag="ClothDRAFT_2525" /note="Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980" /db_xref="CDD:48529" misc_feature order(22990..22992,23098..23106) /locus_tag="ClothDRAFT_2525" /note="dimer interface; other site" /db_xref="CDD:48529" misc_feature order(22996..22998,23011..23013,23107..23109,23119..23121) /locus_tag="ClothDRAFT_2525" /note="[2Fe-2S] cluster binding site; other site" /db_xref="CDD:48529" gene complement(23403..24023) /locus_tag="ClothDRAFT_2526" CDS complement(23403..24023) /locus_tag="ClothDRAFT_2526" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430665.1" /db_xref="GI:256005709" /translation="MYDARNNNNFDQFISSFYTADMLSQEDIEALKLGFYSERIEYTI EPLERVYGKLIAEFTYKEISKIRFNNNRFALSVYEVTAVLLKTNSGWKILTLDYSQSS PLTFPQDVVTAFYDARNTRDFDTYINCFYFADLLSESDLESLKYPYFTDTPYTIKSEI EPISLSVTDSNNVTFKYYEIETITAEKSKLLRKNEVTVNLKKKNDE" gene 24603..26972 /locus_tag="ClothDRAFT_2527" CDS 24603..26972 /locus_tag="ClothDRAFT_2527" /inference="protein motif:PFAM:PF00759" /note="PFAM: glycoside hydrolase family 9; cellulosome protein dockerin type I; KEGG: hch:HCH_02464 cellulase" /codon_start=1 /transl_table=11 /product="glycoside hydrolase family 9" /protein_id="ZP_05430666.1" /db_xref="GI:256005710" /db_xref="InterPro:IPR001701" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MREKKIFSKRTKALIVSFVILALMVFPVGTVNISAANVEYNYAK ALQYSIYFYDANMCGTGVDENGQYNWRGDCHVYDAELPLDSVNTNMSDAFIRENISVL DPDGDGKVDVSGGFHDAGDHVKFGMPEAYSGSTLGWGYYEFREQYKQTGQDQHIETIL RYFNDYFMRCTFRDKDGNVVAFCYQVGDGDIDHAYWNPPEIDDMFRRGWFATKHLPST DCVSAAAASLAVNYFNFKDTDPEYAEKSLDYAKALFDFAQKNDKEVNADGPKGYYTSS KWQDDYCWAAAWLYLATQDDNYLNELFKYYDYYAPSCWTHCWNDVWAGTACILAQIDD LYDKDSEEFENRYRQAANKSPYEPIDFWAEVAKLVENWMYGKTVTITPGGYAFLNKWG SARYNTATQFVALVYDKHHGDAPSAYSQWARSQMEYLMGNNPLNRCYIVGYSDISVKF PHHRAASGLSKCEDPDPHKYVLYGALVGGPDENDQHIDMTSDWVYNEVTIDYNAAFVG ACAGLYRYFGDPSMEITPNFPPKVEISDPDNGGSYWVEAFGVDIVQSDGPKATEVTLY VRSDSRKPSKNISVRYFFDATGMSSVDPDKMEIRQLYDQTAAETDYAAKLTGPHHYKD NIYYVEISWEGFAIANSNKKYQFALGTYTWGNSWDPTDDWSYQELKIEESNYTGTPAR NNRICVYDAGVLVGGIEPDGTTPQSPTPSPTPTPPQEPEFTYGDLNGDGRVNSSDLAL MKRYVVKQIEKLNVPVKAADLNGDDKVNSTDYSVLKRYLLRSIEVIPIK" sig_peptide 24603..24710 /locus_tag="ClothDRAFT_2527" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.758 at residue 36" misc_feature 24654..26141 /locus_tag="ClothDRAFT_2527" /note="endoglucanase; Region: PLN02420" /db_xref="CDD:178040" misc_feature 24723..26135 /locus_tag="ClothDRAFT_2527" /note="Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959" /db_xref="CDD:186543" misc_feature 26778..26837 /locus_tag="ClothDRAFT_2527" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" misc_feature 26880..26942 /locus_tag="ClothDRAFT_2527" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene 27141..28241 /locus_tag="ClothDRAFT_2528" CDS 27141..28241 /locus_tag="ClothDRAFT_2528" /inference="ab initio prediction:Prodigal:1.4" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430667.1" /db_xref="GI:256005711" /translation="MTKGRIRHMFPGGNTSQGFFSYYDYILGQEEANRIICIKGGPGV GKSTFMKKIGKEMVERGYDVEFMHCSSDNNSLDGVVIPSLKIALLDGTAPHVVDPKNP GAVDEIIHLGDFWNEKELRKNKEGILRDNKEVGRTFRRAYRYIKAAYFIYEDNMEIVS RCMDNAKVNKLSDRLKDEIMGDKDIADRQGRDRKLFASAITPNGLVNYLDTLINTDKV YVLKGMPGTGTERVIQKIKEAAVERGYDVESFYCALNPYKLEHLIIPGLNVSITTSND YHSANVENTAEYNLDEYLDMTELGKYQETLENNKKNFEMLLDTAIKTIAKAKAFHDSM ENYYIPNMDFDAVERCYEATLNRILEYAKECH" misc_feature 27147..28232 /locus_tag="ClothDRAFT_2528" /note="hypothetical protein; Provisional; Region: PRK06851" /db_xref="CDD:180730" misc_feature 27225..>27374 /locus_tag="ClothDRAFT_2528" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009" /db_xref="CDD:99707" misc_feature 27258..27281 /locus_tag="ClothDRAFT_2528" /note="Walker A motif; other site" /db_xref="CDD:99707" misc_feature 27261..27284 /locus_tag="ClothDRAFT_2528" /note="ATP binding site; other site" /db_xref="CDD:99707" gene 28269..29498 /locus_tag="ClothDRAFT_2529" CDS 28269..29498 /locus_tag="ClothDRAFT_2529" /inference="protein motif:PFAM:PF00404" /note="PFAM: cellulosome protein dockerin type I" /codon_start=1 /transl_table=11 /product="cellulosome protein dockerin type I" /protein_id="ZP_05430668.1" /db_xref="GI:256005712" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MTPFFTSLEHDLKSVIQYNKIKVGTTNRFILSPIYLIAFLFLSA ISSNALFFTDTRGYTVKRKILIVFVLLSIAISQFLYFEVGCFDVYAWNKAVIGDVNAD GVVNISDYVLMKRYILRIIADFPADDDMWVGDVNGDNVINDIDCNYLKRYLLHMIREF PKNSYNSAPTFTPIPTFTPTPTPTKAPAAPANTQSGILNDGYFPPGTSKHELIARASS LKVSEVKAIIKKQVDEHWDVIRDVCGFKNKEVAYAFFFGMATRESTFRAATETGSGAS HAFGPLQTAETAYANANPNYMPEHNVPEMHQYDFTEYNFYDVGISVHMGIRHFLHFAR LAKEKYSGRDIARHGLMGYNTGWIDGADESWIVRYADETAALGAWYLRNNHMSDDEFT WDTDPRVDRSNPWEIYY" misc_feature 28560..28622 /locus_tag="ClothDRAFT_2529" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" gene 29809..32979 /locus_tag="ClothDRAFT_2530" CDS 29809..32979 /locus_tag="ClothDRAFT_2530" /inference="protein motif:PFAM:PF07719" /note="PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: hypothetical protein" /codon_start=1 /transl_table=11 /product="Tetratricopeptide TPR_2 repeat protein" /protein_id="ZP_05430669.1" /db_xref="GI:256005713" /db_xref="InterPro:IPR001440" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /translation="MGIFNIYTLFGDRKSKAEKLSKKGDELFLNNKYAESVNYYKKAI KTYAKYFEAYVNLGYTLIILGKYEECIRYCNRALALNPQDASELYFIKAECFKKMKRY REALENYIKAVEIRKRVFYLIPLAILLYDMEEYDKALEIFDTLEALDLKYNDDLESIF LYKGKIMEKKGRFKEAIDYFDKALEVNPANAEIYDKKASSLYYLGRDTDDMDLIKESI IYYRKALEIDGEYLHSLNGIAVSLEVLGNADEALIYYDKALEVYPDFVLVHYNKANLL MNLSRNEEALYHYDKAIQIDRYCVDAYIEKAELLCKMEKYADALKVLDNILNIVEASD IRDRNEKICTLLKCKGEAFHIMGKFNEAIECYDKALAVDKDRADVLVKKGEAYNRLGM PQEAILMYEKALGVRNDYYIAYFLMGVTYKHLDEYQLALEAFDCYINAVPKVPEAYVE RAEVLQFMQRYEEAKEDCDQALVLRPQFGSACYRKSLILCELGKYDEAIEILEKLLDD EEFCDIAGYFKGVALKNLGRYEEALEYVDGYITKYPGYREPYLEKADILIALEEYEKA MEACNVLLDRDAEDIGALVKKSGVFFRQDKFEEALKCIEDAMALSLDHHALYYYKAEI LRNMGKPEEAIEFFDKYIEKVPNHPNPYIGRAKSLYVMQEYEKALECCEKAISLDDKY IEGYYSKAHILLQMDKYEDVLELLDKIKEIDPEFPMFYYDRAEVFKRMGNHEKALQEI DIYLEKFPDDGYAHEKRANILFTLGRLDEAIEECDKAIEFEPELLDAYYGKGYILYYT GRFKESLSYFDKVIELNSKSAYAYYSKGNALKYLGDFEGALENYNYAINLWHEFAECY SAIGHLYFLVGNYTNSMIFYDRAESLKPDYIYPYIGKSQLYMTLGDMESAIRYSDKAL EISPDDAEVHNNKGKILGYFGMFDEAVSSFLTAIELNDSQAEYYYNLGNAYLMINEFE NAIESYNKAINLYPEYEAAYVGIGKAQMCLENIEEALKNFNKAIELNPRSAEAYYSKS EALRILDEEEEAQECYEKALELGYNA" misc_feature 29962..30255 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(29962..29967,29971..29976,29983..29988,30076..30081, 30085..30090,30097..30102,30175..30180,30187..30192, 30199..30204) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(29980..29982,30016..30018,30028..30030,30037..30039, 30085..30087,30121..30123,30133..30135,30142..30144, 30184..30186,30220..30222,30232..30234,30241..30243) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 30001..32757 /locus_tag="ClothDRAFT_2530" /note="putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917" /db_xref="CDD:163072" misc_feature 30283..30600 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(30283..30285,30289..30294,30301..30306,30391..30396, 30400..30405,30412..30417,30514..30519,30526..30531, 30538..30543) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(30298..30300,30334..30336,30346..30348,30355..30357, 30400..30402,30457..30459,30469..30471,30478..30480, 30523..30525,30559..30561,30571..30573,30580..30582) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 30511..30795 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(30514..30519,30526..30531,30616..30621,30625..30630, 30637..30642,30718..30723,30730..30735,30742..30747) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(30523..30525,30559..30561,30571..30573,30580..30582, 30625..30627,30661..30663,30673..30675,30682..30684, 30727..30729,30763..30765,30775..30777,30784..30786) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 30841..31113 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(30841..30843,30847..30852,30859..30864,30949..30954, 30958..30963,30970..30975,31051..31056,31063..31068, 31075..31080) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(30856..30858,30892..30894,30904..30906,30913..30915, 30958..30960,30994..30996,31006..31008,31015..31017, 31060..31062,31096..31098,31108..31110) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 31045..31293 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(31045..31047,31051..31056,31063..31068,31153..31158, 31162..31167,31174..31179,31255..31260,31267..31272, 31279..31284) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(31060..31062,31096..31098,31108..31110,31117..31119, 31162..31164,31198..31200,31210..31212,31219..31221, 31264..31266) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 31456..31749 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(31459..31464,31471..31476,31561..31566,31570..31575, 31582..31587,31663..31668,31675..31680,31687..31692) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(31468..31470,31504..31506,31516..31518,31525..31527, 31570..31572,31606..31608,31618..31620,31627..31629, 31672..31674,31708..31710,31720..31722,31729..31731) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 31657..31953 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(31657..31659,31663..31668,31675..31680,31765..31770, 31774..31779,31786..31791,31867..31872,31879..31884, 31891..31896) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(31672..31674,31708..31710,31720..31722,31729..31731, 31774..31776,31810..31812,31822..31824,31831..31833, 31876..31878,31912..31914,31924..31926,31933..31935) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 32074..32352 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(32074..32076,32083..32088,32173..32178,32182..32187, 32194..32199,32275..32280,32287..32292,32299..32304) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(32080..32082,32116..32118,32128..32130,32137..32139, 32182..32184,32218..32220,32230..32232,32239..32241, 32284..32286,32320..32322,32332..32334,32341..32343) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 32368..32661 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(32368..32373,32377..32382,32389..32394,32479..32484, 32488..32493,32500..32505,32581..32586,32593..32598, 32605..32610) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(32386..32388,32422..32424,32434..32436,32443..32445, 32488..32490,32524..32526,32536..32538,32545..32547, 32590..32592,32626..32628,32638..32640,32647..32649) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" misc_feature 32572..32868 /locus_tag="ClothDRAFT_2530" /note="Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189" /db_xref="CDD:29151" misc_feature order(32572..32577,32581..32586,32593..32598,32683..32688, 32692..32697,32704..32709,32785..32790,32797..32802, 32809..32814) /locus_tag="ClothDRAFT_2530" /note="binding surface" /db_xref="CDD:29151" misc_feature order(32590..32592,32626..32628,32638..32640,32647..32649, 32692..32694,32728..32730,32740..32742,32749..32751, 32794..32796,32830..32832,32842..32844,32851..32853) /locus_tag="ClothDRAFT_2530" /note="TPR motif; other site" /db_xref="CDD:29151" gene 33023..33481 /locus_tag="ClothDRAFT_2531" CDS 33023..33481 /locus_tag="ClothDRAFT_2531" /inference="ab initio prediction:Prodigal:1.4" /note="KEGG: sea:SeAg_B3342 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="ZP_05430670.1" /db_xref="GI:256005714" /translation="MNGIKKFKWIIGTTSIILVAFLAVVMNSDKWGSGAVSAYGKVSQ DAIEVSLINLIATPEQYDGKLVRVTGVATVEFENSGLYLSRDDYKNAITKNAVCLTLD EKLLGTTYENLKKTNGKYVLVEGIFNGKEKGHFDRCSGTIDNITRYEVWK" sig_peptide 33023..33106 /locus_tag="ClothDRAFT_2531" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.940) with cleavage site probability 0.608 at residue 28" gene 33774..34160 /locus_tag="ClothDRAFT_2532" CDS 33774..34160 /locus_tag="ClothDRAFT_2532" /inference="protein motif:PFAM:PF00404" /note="PFAM: cellulosome protein dockerin type I" /codon_start=1 /transl_table=11 /product="cellulosome protein dockerin type I" /protein_id="ZP_05430671.1" /db_xref="GI:256005715" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR002105" /translation="MLKFQRNFGKYYLFKGYVQMRKIKIINYFPLFFMLFIVILRVFF VSSSAEVANTADTNIKLLQNSEAPFKYGDLNGDNNINSSDYTLLKRYLLHTIRESPEK RPHPHFGEKYSGVDNLSNLIDLSYLK" sig_peptide 33774..33923 /locus_tag="ClothDRAFT_2532" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.477 at residue 50" misc_feature 33990..34052 /locus_tag="ClothDRAFT_2532" /note="Dockerin type I repeat; Region: Dockerin_1; pfam00404" /db_xref="CDD:144118" ORIGIN 1 ttaccggttc tttttttata acgaaaaaag gtcattcctt ttgaaaaata cttgacatta 61 ctggttgaca ttttatatat ttaaagtata aggaacataa tttgcaccga tcctgttcta 121 aattctgaaa ttaacaagta tttggggttg tattatatat ggggttgtat cattggggta 181 ttataatcaa tgcaatctat tagtaaaagt ctatgctgtc atatccatca aatctttaaa 241 gcaggtgtct tttgtaacaa attcaataaa cacccattaa ctgtttgtgc gctatgggct 301 atattagatt gaagcttctc acatggcata tttcaaacta ataatataaa accctcaagg 361 aggtgaactc ataagaaggg ttgtaaacct tttttaatta gtttttaatt agtttgaaat 421 gcaaaagaaa tgagaaagct tcaatcctga ttttagcaat tctttaacgg gagggaaaag 481 aatgaaattt agaaggtcaa tttgtactgc tgttttgttg gcggttttat tgacacttct 541 ggtaccgaca tccgtgtttg ccttagaaga taattcttcg actttgccgc cgtataaaaa 601 cgaccttttg tatgagagga cttttgatga gggactttgt tatccatggc atacctgtga 661 agacagcgga ggaaaatgct cctttgatgt ggtcgatgtt ccggggcagc ccggtaataa 721 agcatttgcc gttactgttc ttgacaaagg gcaaaacaga tggagcgttc agatgagaca 781 ccgtggtctt actcttgaac agggacatac atatagagta cggcttaaga tttgggcaga 841 tgcgtcctgt aaagtttata taaaaatagg acaaatgggc gagccctatg ctgaatattg 901 gaacaacaag tggagtccat acacactgac agcaggtaag gtattggaaa ttgacgagac 961 gtttgttatg gacaagccaa ctgacgacac atgcgaattt acattccatt taggtggcga 1021 attggcagca actcctccat atacagttta tcttgatgat gtatcccttt atgacccaga 1081 atatacgaag cctgttgaat atatacttcc gcagcctgat gtacgtgtga accaggttgg 1141 ctacctgccg gagggcaaga aagttgccac tgtggtatgc aattcaactc agccggtaaa 1201 atggcagctt aagaatgctg caggcgttgt agttttggaa ggttataccg aaccaaaggg 1261 tcttgacaaa gactcgcagg attatgtaca ttggcttgat ttttccgatt ttgcaaccga 1321 aggaattggt tactattttg aacttccgac tgtaaacagt cctacaaact acagtcatcc 1381 atttgacatt cgcaaagaca tctatactca gatgaaatat gatgcattgg cattcttcta 1441 tcacaagaga agcggtattc ctattgaaat gccgtatgca ggaggagaac agtggaccag 1501 acctgcagga catatcggaa ttgagccgaa caagggagat acaaatgttc ctacatggcc 1561 tcaggatgat gagtatgcag gaatacctca gaagaattat acaaaggatg taaccggtgg 1621 atggtatgat gccggtgacc acggtaaata tgttgtaaac ggcggtatag ccgtctggac 1681 attaatgaac atgtatgaga gggcaaaaat tagaggtctt gacaactggg gaccatacag 1741 ggacggcgga atgaacatac cggagcagaa taacggttat ccggacattc ttgatgaagc 1801 aagatgggaa attgagttct ttaagaaaat gcaggtaact gaaaaagagg atccttccat 1861 agccggaatg gtacaccaca aaattcacga cttcagatgg actgctttgg gtatgttgcc 1921 tcacgaagat ccccagccac gttacttaag gccggtaagt acggctgcga ctttgaactt 1981 tgcggcaact ttggcacaaa gtgcacgtct ttggaaagat tatgatccga cttttgctgc 2041 tgactgtttg gaaaaggctg aaatagcatg gcaggcggca ttaaagcatc ctgatattta 2101 tgctgagtat actcccggta gcggtggtcc cggaggcgga ccatacaatg acgactatgt 2161 cggagacgaa ttctactggg cagcctgcga actttatgta acaacaggaa aagacgaata 2221 taagaattac ctgatgaatt cacctcacta tcttgaaatg cctgcaaaga tgggtgaaaa 2281 cggtggagca aacggagaag acaacggatt gtggggatgc ttcacctggg gaactactca 2341 aggattggga accattactc ttgcattggt tgaaaacgga ttgcctgcta cagacattca 2401 aaaggcaaga aacaatatag ctaaagctgc tgacagatgg cttgagaata ttgaagagca 2461 aggttacaga ctgccgatca aacaggcgga ggatgagaga ggcggttatc catggggttc 2521 aaactccttc attttgaacc agatgatagt tatgggatat gcctatgact ttacaggtga 2581 ctccaaatat ctcgatggaa tgtttgacgg cataagctac ctgttgggaa gaaacgcaat 2641 ggatcagtcc tatgtaacag ggtatggtga gcgtccgctt cagaatcctc atgacaggtt 2701 ctggacgccg cagacaagta agagattccc tgctccacct ccgggtataa tttccggcgg 2761 tccgaactcc cgtttcgagg acccgacaat aaatgcggcc gttaagaagg atacaccgcc 2821 acagaaatgt tttatcgacc atacagactc atggtcaacc aacgagataa ctgttaactg 2881 gaatgctccg tttgcatggg ttacagctta tcttgacgag cagtacacag acagtgaaac 2941 cgataaggta actattgatt cgcctgttgc aggagaaaga tttgaagccg gtaaagacat 3001 taatataagc gcaactgtta aatcaaaaac tcctgtaagc aaagtagagt tttacaatgg 3061 agatacgctt atttccagtg acacaactgc accttacaca gcaaagataa caggagccgc 3121 tgtcggagca tataacctta aagcggttgc agtgctgtct gacggaagaa gaattgagtc 3181 accggtaact cctgtacttg ttaaggtaat tgtgaaacct actgtaaaac ttactgcacc 3241 caagtcaaat gttgtggctt atggaaatga gttcctgaag attacagcaa cagccagtga 3301 ctctgacggc aaaatctcca gggttgattt ccttgttgac ggtgaagtaa tcggttcaga 3361 cagggaagca ccttatgaat atgagtggaa agctgtggaa ggcaatcacg aaataagtgt 3421 aattgcttat gatgatgacg atgcggcttc aacacctgat tccgtaaaaa tatttgtaaa 3481 acaggcacgg gatgtaaaag tacagtattt gtgcgaaaat acgcaaacat ccactcagga 3541 aatcaagggt aaattcaata tagttaacac aggaaacaga gattattcgc tgaaagatat 3601 agtattaaga tactacttta ccaaggagca caattcacag cttcagttta tctgctatta 3661 tacacccata ggctccggaa atctcattcc gtcctttggc ggctcgggtg acgagcatta 3721 tctgcagctg gaattcaaag atgtcaagct gcctgccggc ggtcagactg gggaaataca 3781 gtttgttata agatatgcag ataactcctt ccatgatcag tcgaacgact attcgttcga 3841 tccaactata aaagcgttcc aggattatgg caaggttacc ctgtataaga atggagaact 3901 tgtttgggga acgccgccgg gcggtacaga acctgaagaa ccggaagagc ctgaagaacc 3961 ggaagagcct gcgatagttt acggcgactg taatgatgac ggcaaagtaa attcaacaga 4021 cgtcgcagta atgaagagat atttaaagaa agaaaatgtt aatattaatc ttgacaatgc 4081 agatgtgaat gcggacggca aagttaactc aacagacttc tcaatactta agagatatgt 4141 tatgaagaac atagaagaat tgccatatcg ataagataat ctgaaattat ttgtgaagga 4201 ccggtttttg ccggtccttt ttaaaattaa tagacttagt gaaactttta ttttttgttt 4261 ggttattgat aataaaacgt ttcatctttt gtacgccgga ttcatgcaat cgggtttttt 4321 tacatagaaa ggtttttcgg caagtttatc ttgtactatt ctcagagctt cgccaaaacg 4381 ctggaaatgt acgacttctc tttctctcaa aaatcttaac gggtcaatta catcagggtc 4441 gtcggtcaga tttataaggt tttcataagt ggcacgggct ttttgttctg cggccatgtc 4501 ttcatgcaag tcggcgatgg gatcaccttt tgactgtata tatgctgcgg taaaaggggt 4561 gccggaagca ctcatggggt agacggcatg gtcatggtct gtgtagtaag caccaagtcc 4621 aacgcgttcc agcacatccg ccgggacacc tcttgtaagc tggtacacta tggttccaat 4681 catttcaaga tgtgccaatt cttcggttcc tatatcattt aaaatacctt ttgcctcatt 4741 tgtaggcata ctgaatctct ggcttaaata tctcaaagaa gcggcaagtt ctccgtcagg 4801 accgccgtac tgggaaataa tatactttgc caattttgga tttggatttt ttatttttac 4861 cggatattca agtttctttt cataaaccca cattttttta cctcctcgga acaatcatag 4921 aaatatacaa ataaattctg tttaacacga caaggctatt cccacggcca tgggctgttt 4981 atccactgcc acgggcattt gtaaggggta ctttgggcgg ttagcgggcc atacaatctc 5041 tcgtattcgt ttctgagtat ttttgctctt tgggcacagt tgtaaaaaag cattatggca 5101 ttctggtcat atgggtgcgt atttaaatac agatttaaat cgataagtgt aaaatcggca 5161 gccattactt cctttagcag ctgggcttga ttgggattca tattttcacc tccttaggcg 5221 tccacggtgt attcagggtc ttttccgtag ggactgtaca gttcgggaaa tattgttccc 5281 gcattaagac ccttcacagg cggaaaaatg cagctcatat gttggaacgg aacataagca 5341 tgggccagtt tcattggcat gcagtgaatt tttacattgt gactcatgct ttgggtatgg 5401 cagggttgca tcatgccttg gccatggaca ggttgcagca taccgggatt gtaactagga 5461 tattccatca tttcgattac ctccaggaca aaattttgcg ttggataatt ttatgttgag 5521 taattttatt aacataatat tcagataaaa agtaaaaagt tctttgatat tccagttgat 5581 aaaaaggata taatatttat tgaaaaattt ttttatattc attctttaca gtatctagtt 5641 agtatgttag aatgtttgag ggaaatataa ctatgagctc ggttcagggt aactccgacc 5701 ctttacttag ccatagggat taaaaaagaa ggaggatgtt ttataatgca aaaggaatta 5761 aaacaagaaa taatcaacaa attcaagtta catgaaacag ataccggttc accggaagtg 5821 cagattgctc ttctgacgga aagaattaat catcttactg agcatttaaa ggttcacaag 5881 aaagactatc attcaagaag aggtcttctt aaaatggttg gacacagaag aggtttgctg 5941 aactatctta tgaagaccga cattgcaagg tatcgtgcca ttgtcgagaa gttaaatctc 6001 aggaaataat aaaaaggcgg agtaatccgc ttttttgtat tatcacatca taaacatcat 6061 aaatacaatt tatataaatc tgaaataata aaaaataaat ttgatttgga taagagtaaa 6121 agtgattgta aactgcagac cgtagaaggt agattgtgct gcaaaagcaa aaaaatgggc 6181 ttttgctgta gaatctacat cctacagtct gtggtttaac taataagagg aggattgtat 6241 aataatgtat aaaactttca gcatggagct agccggaaga acacttacta ttgaaactgg 6301 gaaacttgct caactggcaa acggttcagt attggtcaga tacggtgata ctgttgtact 6361 ctcaacagct accgcttcgg caacaccaag agagggagtc gatttttttc ctttgagtgt 6421 ggattatgaa gaaagattgt atgctgtagg aaaaattccc ggaggtttta taaaaagaga 6481 aggtaaaccg tcggaaaagg caatacttac agccagagtt atagatagac ccttaaggcc 6541 tttgttcccc aaggacttga ggaatgatgt ggctattgta aatacagttt tgtccgttga 6601 tcaggacaat tcaccggaac ttgccgcttt attgggatcc tccattgccg tgtcaatttc 6661 ggacataccg tttaacggtc ctgtcggagc agttattctg gggcttattg acggtgaagt 6721 gattataaat ccgaccgaaa aacaaagaga aataagccag atgtatgtta ctttggcagg 6781 cacaaggaat aaaattgtca tgatagaggc aggagcaaac gaggttcccg atgaagtcat 6841 gctggatgcc atcaaaaaag gacatgagga aataaagaaa attgttgact ttattgacgg 6901 aattgtaaag gaagtcggca aacctaaatt tgaatatgaa tctgcggaag ttcccgagga 6961 aatattcaat gccgtcaggg aatatgctta tgacaagatg agggaagccg tacttgctgt 7021 ggacaagcag gtaagagaca aaaacattga tgatcttaca aaagaaataa cggagcattt 7081 tgcggaagtg ttccctgaaa tggaaccagc cattaaagaa gcaatataca aactggagaa 7141 gaaagttgta agggaatata ttttggaaga gggcagaaga gttgacggca gaagacttga 7201 cgaaataagg cctttgtcgg ctgaagtcgg gctgcttccg agagttcatg gttcaggtct 7261 tttcacaagg ggacagactc aggtgctttc aagtgttacc ttgggcgcca tgggggatgt 7321 tcagatactg gacggtattg acactgaaga aaccaaaaga tatatgcatc actataattt 7381 ccctggattc agcgttggcg aagctaagag ttcaagaggt ccgggaagaa gagaaatcgg 7441 tcacggagct ctagcggaaa gagcattgga gcctgtgatt ccaagtgaag aagaattccc 7501 ttatacaata agggtggtat ctgaagttct tatgtcaaat ggttccacat ctcagggaag 7561 cgtttgcgga agcactctgg cacttatgga tgcaggtgtg cctatcaaaa agcctgttgc 7621 gggaatttct gccggtttgg ttgttgacga aaataatccc gacaggtttg ttacttttat 7681 ggatatccaa ggcatagagg atttctttgg agatatggac tttaaagttg ccggaacgaa 7741 ggatggaata acagccattc aggttgatat aaagatagac ggacttacgg aggaaattat 7801 aaaacaggca tttgaactta caagaaaagg tcgtttgtat attattgaca atgtgttgct 7861 gaaggctatt ccggaaccga gaaaacaaat gtcaaaatat gcgcctaaga ttatttcaac 7921 taccataaat ccggataaaa tcagggaagt aataggcccc ggaggtaaaa tgataaacaa 7981 gataattgac gaaaccggag taaagattga tataaacgac gacggtagag tttatatatt 8041 cagttcggat attcaagccg gaaaaagagc tcgcagtatg atagaggcaa tagcaaaaga 8101 tattgagcca ggccaggtat ttttgggcag agttatcaga gttacatcct ttggagcttt 8161 tgtagagttt cttccgggaa aagaagggct tgtgcatata agcaagctgg acaagaagag 8221 agtcgaaagg gttgaagaca tagtaagagt cggagatcag atacttgtta aggttataga 8281 aattgacaag cagggacgtg taaatctttc aagaaaggat gcaatggaag atgaatggga 8341 taaataggat ggtttatcct ttacagagct ttttaaagat atcccattta tgaaagtaag 8401 gcgtgaattt gattctgttt gcgccttact taatttcatg tacaaaagat gatttcatat 8461 ataaaatatg gaggctgtat gtataaacgt ataaaattag aaaacggtgt cagagttgtt 8521 tgcgaaaaaa ttccctatct cagatctgtt tctatcggta tctgggttgg aaccggttca 8581 aggaatgaaa gccaatcaaa caacggaata tctcacttta ttgaacatat gctttttaaa 8641 gggactgaca acagaagtgc ccgggagatt gccgacagca ttgacagcat tgggggtcaa 8701 cttaatgcgt ttacaggaaa ggaatgtacc tgttattata caaagacttt ggattcccat 8761 gctgatattg ccttggacgt tctttcggat atgtttttta attcaaggtt tgaagaaaaa 8821 gatatagaag ttgaaaagaa agttattttg gaagaaatag gcatgtatga ggattctccg 8881 gaggagctgg tgcatgatat cctgtctgaa accgtatggg aggataattc acttggactt 8941 cccattttgg gaacacggga aacccttttg aatatcaaca aagataaaat caaagcttac 9001 attaatgaga gatatttgcc gcagaatacg gttatagctg tggccgggaa ttttgaagag 9061 gacagaataa ttgatgttat aaaagaaaaa ttcggcggat ggaatgccag cggaaaagac 9121 agtaaaacta ttgaagatgc aaagtttaag gtgaattcca aaatcaaggt gaaagatacg 9181 gaacaaatac acatatgtat gggatttgaa ggagttgcgc acggaagtga tgagttgtat 9241 cctctgcttg ccgtaaacaa tgtattgggc ggcggaatga gctccagaat gtttcagaaa 9301 atcagggaag aaaaaggatt ggtgtattcc atatactcat acccgtcatc ttataaaaat 9361 gccggtttgt ttacgatata tgcaggaatg aatgcagagc atttggaaaa ggttgtggag 9421 cttataataa aagaaataaa gatactttta aaagaaggac tttctaagga tgaacttgaa 9481 aaatccaaag aacagcttaa gggaagctat atactcggac ttgagagtac cagcagcaga 9541 atgaacagta tgggaaaatc ggaagtactt atggacagaa tatatactcc ggatgagata 9601 ttaaagaaga ttgatgcggt aaatcaagaa agtgttgaac gggttataaa acaaattttt 9661 tgtttggata aaatcagttt tgcgatagtg ggtaacataa aaaaggaaat agatattaga 9721 aaaataatta atgcttaaag ggcaaaaatc ctcgattcca attagtggtg tcggggtttt 9781 tttatgcctt gatttgtaaa gcttacttat aattatacaa gcacttatat ttttaaatgt 9841 acataagata tactaagtca ccataagttg gtttataata ccagaagaaa aataatattg 9901 gatttaatct tacttgtaag tggacagaag gaggtaatat agtgaagaat aaaaaattta 9961 caattatcgg cggtgatctt aggagtgtca agctggctga gttgattgta gcggaaggga 10021 ataaagttaa catatatggg tttaagaatg ctaacttcga gataggtatt gaagaaagcg 10081 aagatcttga ccacgctatt ggggaggcgg atgtaatagt aggtcctact ccatgttcaa 10141 cagataatga aacaattaat acaccttttc attctcaaaa aatttttatt aaagacatat 10201 tcaaaaagat gaataaaagc cagttgttta ttgccggaag aataaccgat aagattgccc 10261 agcttgcaga tgtctacaac gtatattcag ttgatttgct tgaaagagaa gaaatggcgg 10321 ttttaaatgc cattccgact gcagaagggg caattcaaat tgcaatggag gaaatgccta 10381 taactcttca tggaagcaat gcattaattt tagggttcgg aagaattgga aagatacttg 10441 caaaaatgct ccatggaatt ggaagcaacg tgtatgtcga ggccagaaaa tattccgacc 10501 tggcttggat tgaaagttat ggatacaaac cggttttcat aactgagctt gaaagttaca 10561 tagacagggc aaatgttatt tttaatacta ttcccagcat tgtactggat gaaaatttgc 10621 tcaggaaggt aaacaaggat tgccttttga tagatcttgc ttccaagcct ggcggaattg 10681 actttgaaaa agcaaaagag atgggattaa aaacaatatg ggctctttct cttccgggaa 10741 aagtagcacc ggtgacagca gcaaaattca taaaagacac tattagcaat attattgatg 10801 agttgggggt ataagaaaat gttgctggaa gggattaaaa ttgggtttgg acttaccggt 10861 tccttctgca ccatagacaa agtaataccc gagattgaaa agcttgtaag caacggtgca 10921 aaggttttcc ccatactgtc gggttcggta agcaaatttg atacaaggtt tggaagagcg 10981 gaggatttaa ggctcaaact tgaagggatt acgggaaaca aagttataga cagcattgtt 11041 gatgcagagc caataggtcc gaaatctctt cttgatataa tggttgtagc gccgtgtacc 11101 ggcaataccc tggcaaaaat tgcaaatgga ataaccgaca caacggtaac tatggcgtgc 11161 aaggctcatc ttaggaatca aaagccggtg gttttgtcta tttctacaaa tgacgggcta 11221 ggcgcaaatg caaaaaacat tggattgctt ttaaatatga aaaatatata tcttgtacct 11281 tttggccagg acggaccggg taccaagccg aattctttgg ttgcagacac aacacagata 11341 atgccgacaa tcctcgaagc tttaaatcat aagcagattc agccgatact tattaaatat 11401 tgattagtct gagacttaaa ccggttttaa taagaagcag gagctaaaat tttagcttcc 11461 gcttttttta ttttctcaga aaatttattt ttgtgaaaac tatataaaac tttcattcaa 11521 attaatatga aaatgtataa aaagtgtatt gactttgatt gtattaaacg gtaaaatgat 11581 atcgataaca aaatatcgat aaaaaaatac cgataaataa atatcgatat caataatctt 11641 atagtacttg agttaaaagg ggtggattgg ctaaaatagt ttaataagta attattaaaa 11701 aagaaaggaa ccaatatata tgaataatcc gaaagctatc tcaaaacaga ctcttttaag 11761 attaccttca tatttaagtt acttaaaatc gctgccaaag caggacggtg aatatgtatc 11821 ggctacaatg attgcttcgg cgctgggact gaatgatgtg caagttcgaa aggatctggc 11881 ctgtgtaagc aaaaaaagcc gtccaaagct tggatatgtt gctgaagagt tgataaggga 11941 tatagagagt tttcttgggt atgactcttt gaacgatgcg ataattgtgg gcgcgggaag 12001 gcttggagga gctcttttat cctatgaggg ctttaaagaa tatggattaa atattgttgc 12061 agcgtttgat gttgatgaaa gtaaaatcgg cactgaaatt tgcgggagaa aaattttccc 12121 tttggacaaa atgaaggaac tgtgccggcg gatgaaaatt cgtatcggta taataaccgt 12181 ccctgcagat tcagcccaaa aagtatgcga catgcttgta gacagcggaa tatatgcaat 12241 atggaatttt gcacctgttc accttaaagt accggataac attttagtcc agcaagaaaa 12301 catggcggca tcgctggctg tactttccgc acacttggca gaagcaataa agaataatgg 12361 aatcggaaaa ggagataagg aaaatgacga aaatagcgaa taaatacgaa gttattgata 12421 atgttgaaaa gcttgaaaag gctttgaaac gtttaagaga agctcaaagt gtttatgcaa 12481 cctatacaca ggagcaggtt gacaaaattt tctttgaggc ggcaatggcg gccaataaaa 12541 tgagaattcc tcttgccaaa atggctgtgg aggaaacagg catgggagtg gttgaagaca 12601 aggttatcaa aaaccactat gcttctgagt atatctataa tgcgtacaaa aacactaaaa 12661 cctgcggtgt tattgaagag gaccctgctt tcggtattaa aaaaatagca gagcctttgg 12721 gggttattgc ggcggttata cctactacga atccgacatc gacagcaatc tttaagactc 12781 ttattgcatt aaagacgaga aatgcaatta ttataagccc acaccccagg gcaaaaaact 12841 caacgataga agcggcgaaa attgttttgg aggcggccgt taaagccggt gctccggaag 12901 gcatcattgg ctggattgat gtgccgagcc ttgaacttac caacctggta atgagagaag 12961 cagatgtgat tctcgcaaca ggcggtcccg gactggttaa agcagcttac tcttcgggca 13021 aaccggctat tggtgtcgga gcgggcaata ctcctgcaat tattgatgat tcggccgaca 13081 ttgtcttggc agtgaactca ataatacatt caaaaacttt cgacaacggt atgatttgtg 13141 cttcagagca atcggtcatt gttctggacg gggtatataa agaggtaaaa aaagaatttg 13201 aaaaaagagg atgctatttc ttaaatgaag atgaaactga aaaggtaaga aaaacaatta 13261 taataaacgg tgcgttaaat gccaagatag taggtcagaa agctcacaca attgcaaacc 13321 ttgcaggttt tgaggtaccc gagactacaa aaattctgat aggcgaagtt accagcgtgg 13381 atatttccga agaatttgcc cacgaaaagt tgtgcccggt actggcaatg tacagggcaa 13441 aggattttga cgatgccctt gataaagcag aaaggttggt agctgacggt ggatttggcc 13501 atacttcgtc actttatata gatacggtaa cacagaaaga gaaacttcag aaattctctg 13561 aaaggatgaa aacctgccgt atattggtta atacgccgtc atcccaggga ggtatcggtg 13621 acctttacaa cttcaagctt gctccgtctc tcaccctcgg ctgcggttcc tggggaggaa 13681 attcagtttc cgacaatgtg ggagtcaagc atttgttaaa cattaaaaca gttgccgaga 13741 ggagagagaa catgctctgg ttcagaacac ctgaaaagat ttatataaaa agaggttgtc 13801 tgcctgttgc attggatgag cttaaaaatg taatgggtaa aaagaaagca tttattgtaa 13861 cggataactt cctgtacaat aacggctaca ccaagccgat tacggataag ctggatgaaa 13921 tgggaattgt gcacaagacc ttctttgatg tgtctccaga cccatccctt gcatctgcca 13981 aagccggtgc ggcagaaatg ctggctttcc agcctgacac cataattgcg gtcggcggcg 14041 gatctgccat ggacgcggcc aaaatcatgt gggtgatgta tgaacatccg gaagttgact 14101 ttatggacat ggcaatgaga tttatggata taagaaagag agtttacacc ttcccgaaga 14161 tgggacagaa ggcatacttt atcgcaattc cgacttccgc gggtacaggt tcagaagtga 14221 caccttttgc ggttattact gatgaaaaaa caggaattaa ataccctctg gccgactatg 14281 aattgttgcc ggacatggct attgtagatg ccgatatgat gatgaatgct ccaaagggac 14341 ttaccgcagc ttccggtata gacgcattga cccacgctct ggaagcctat gtttcaatgc 14401 ttgcgaccga ctatacggat agccttgccc ttcgtgcaat aaagatgata tttgaatatc 14461 tcccgagagc ctatgaaaac ggtgcaagtg acccggttgc aagagagaaa atggccaatg 14521 ccgcaacaat agccggaatg gcttttgcca atgccttttt gggtgtatgc cattcaatgg 14581 cgcacaaact gggtgctttt tatcacctgc cccacggtgt tgccaatgca cttatgataa 14641 acgaagtaat cagattcaac tcatccgagg ctccgaccaa gatgggtact ttcccgcagt 14701 atgaccatcc gcgcacgctg gaaaggtatg cagaaattgc cgattatatc ggacttaagg 14761 gcaagaataa cgaagaaaaa gttgaaaact tgattaaagc tattgatgag cttaaagaaa 14821 aggtgggcat caggaagacc atcaaagatt atgacataga tgaaaaggaa tttttggaca 14881 gactggacga aatggtggaa caggcttttg acgaccagtg cacaggtaca aatccaagat 14941 acccgcttat gaatgaaatc aggcaaatgt atctgaacgc ttattacgga ggtgcgaaga 15001 aatgaagctt gaaaaggtta tagcggtaag aacggacaaa accgtttaca gagacggaga 15061 caaggcaata aaggtctttt ccagcaacta ttcaaaggcc aacgtattga atgaagcttt 15121 aaaccaggcc agggtggaag aaaccgggct taacattccg aagcttcttg aagttacaaa 15181 aattgatggc aaatgggcaa ttgtgacgga gtttattgaa ggaaagacct tagagcagct 15241 tatgaaagaa aatcccttaa aatatgatga atatatgaac ctctttgttg atattcagct 15301 cgaagtgtta agcaaaaggg ctcctttatt aaacaagctg aaagacaaaa tgcacagaaa 15361 aaatctcaga gagcggtctt gatgccacga cgcgctatga gcttcataca agacttcaaa 15421 gtatgcccga ccataacaag gtgtgtcatg gtgatttcaa tcccagcaat attattataa 15481 ccaaagacgg cactccttat atacttgact ggtcgcacgt cacccaggga aacgccagcg 15541 ccgatgccgc gagaacatac ctgttgttct ggctttccgg cgatattgac aaggcagcca 15601 agtatttgaa ccttttctgt aaaaagagcg acactgcaaa gcaatatgtt cagaagtgga 15661 tttcaattgt agcggcatcc cagcttgtaa aaggaagaga agctgaaagg gagttattaa 15721 tgcgctggat tgatgttgta gattacgaat aggaggtatt tgggatgaaa gtgtctattt 15781 gcatagggag ctcttgccac ttaaaaggag caaagcagat agtggaacag ctgcaaagcc 15841 tggttgccga ctataacctg aaagagaaag ttgaacttgg cggggcattt tgtatgaaaa 15901 actgtgttaa cggtgtcagc gtgacagttg atgataaact gttttctgtc actccggaaa 15961 acgtgaaaag cttttttgaa acagagattc ttaaaaaact tgaggactga aaattaaaaa 16021 acaaataagc ggtgctgctt gtggataagg agcgcgagtc taatgaccga atgtttgcaa 16081 actaaaaaat caaattgcaa gaactgctat aagtgtataa gacattgtcc ggttaagtca 16141 ttgaaattca ctgacggtca ggctcatata gtaagggatg aatgcgtttt gtgcggcgaa 16201 tgctatgtcg tttgcccgca aaacgcaaag cagatacgat ccgatgtgga aaaagcaaaa 16261 caactggttt taaaatatga tgtttatgcc agtatagctc cgtcctttgt cgcatggttt 16321 cataacaaaa gcatacatga tatggaacag gcgttaataa agcttgggtt taaaggtgcg 16381 gatgaaacgg cgaaaggtgc ttacattgtc aagaaacaat atgaaaaaat gatagaagag 16441 aaaaaaagca aaattattat atcttcgtgc tgccatacgg taaacacctt gatccaaagg 16501 cattataccg gcgcaattca gtatctggca gatgtagtct cgccgatgct tgcccatgcg 16561 caaatgctga aaaaagaaca taaaggtgca aaggttgtat ttatcggacc gtgcatttcc 16621 aaaaaagacg aagcagaaaa atataaaggt tacgtggaac ttgtgcttac tttcgatgaa 16681 ctggatgaat ggctaaaatc agaaaatatt acaattgaaa gcaatagggg cagctctaaa 16741 gagggaagga ccagaagttt tcctgtttcc ggaggcatta tcagtagtat ggataaagat 16801 ttaggatatc attacatggt agtggacggt atggaaaact gcataaatgc tttggagaat 16861 atagaaagag gagagattga caactgtttt attgagatgt cggcatgcag aggcagttgt 16921 ataaacggtc cgcctgcaag gcgcaaaagc aataatattg tcggagctat attagccgta 16981 aataaaaaca ccggagcaaa agatttttct gtcccgatgc ccgaacctga aaaactaaaa 17041 aaagaattcc ggtttgaagg tgtgcacaag ataatgcccg ggggtactgc catcgaggag 17101 attttaaaga aaatgggcaa gacctccata gagcatgagc taaactgcgg aagctgtggt 17161 tatgacacct gccgcgacaa agcggtagca gtattaaatg gaaaagcaga ccttacaatg 17221 tgtcttccat acctgaaaga aaaagcggaa agcttttcag atgcaattat taaaaataca 17281 cccaacggtg ttatagtatt aaatgaagac cttgagattc agcagataaa caattccgca 17341 aaaagaattc tgaacttaag cccgtctaca gatcttttgg gaagtcctgt tagcagaata 17401 cttgatccta tagattatat tcttgcgttg agagagggca aaaactgtta ctataaaagg 17461 aagtattttg cggaatataa aaaatatgtc gacgaaacca taatttatga taaggaatat 17521 cacgtcatta tcataattat gagggatgtg actgaggagg agaaaatcaa ggcgctgaaa 17581 aacaagcaaa gcgaggcggc aattgaaata gcggataaag ttgtggaaaa gcagatgcgc 17641 gtagtgcagg aaatagcact gcttttggga gaaacggccg ctgagactaa aattgctttg 17701 accaagctga aggagactat ggaggatgaa tgatttatgc gttgatttag gatataaaag 17761 ccttaacaaa tttggggagc agctgtgtgg cgacatgata caggttgtaa aagatgatga 17821 cactacaatt ctggttctgg ccgacggttt gggaagtggt gtcaaggcca atattttatc 17881 cacccttacc tcaaagatta tttcaacgat gattgcagcg catatgggta ttgaagaatg 17941 tgtcaatacg attatgtcaa ctcttccggt ttgcaaggtc agaggaattg cctattcaac 18001 atttaccata ataaaaatta ccaacaacac ctacgcagaa ataattcagt atgacaatcc 18061 tctggtaata cttttgcgga acggtaaaaa atatgattat cctacacaga caaaaataat 18121 atccggcaaa aaaatcgttg aatcaaaaat aaggctgaat tgtgatgatg tgtttgttgc 18181 gatgagtgac ggggcaattt atgcgggagt cggccagact ttaaattacg gctggcaaag 18241 ggagaatatt attgagttta ttgagtctca ttatgacaaa agcctttctg ccaatgctct 18301 tacatctctt ttgattgata cttgcaacaa cctgtatgca aacatgcccg gagatgatac 18361 aaccattgca gcaattaaga ttagaaaaag acaagtagtc aatctgatgt ttggtccgcc 18421 gcagaatcct gaagatgtcc ataatatgat gtctctgttt tttgcaaaac agggaagaca 18481 tattgtatgt ggcggtacca catcaacgct tgcagcgaag tttttgggca aggagcttga 18541 aacgaccatt gattatattg acccgagaat tccgcccatt gccaggattg aaggagttga 18601 tcttgtgaca gagggcgtgt tgacaataag ccgggttctg gaatatgcaa aggattatat 18661 tgggaaaaac attctttata acgagtggca cagcaaaaat gacggtgctt cgataatagc 18721 aagaatgctt ttcgaggaag caacggacat caatttctat gttggaaagg ctattaatcc 18781 tgcccaccag aatcccaatc ttcccatagg atttaatatt aaaatgcagt tggtggaaga 18841 gctttcaaag atacttaagc aaatgggcaa gacaataaat cttagctatt tttgaggtga 18901 gtgacaatga gtgttacaat gagtgaagct tttgattaca gcatgattga caatattttg 18961 tcggaacacg gaacttctga aactgcaatt attgcaatac ttcaaagcat tcaggaagaa 19021 tatcattata ttccgaaaga agtgtttccc tatctttcaa aaaaacttaa agtaagtgaa 19081 gcaaggatat tcagtgttgc aaccttttat gaaaactttt ctttggagcc gaaaggaaag 19141 tatataataa aagtctgcga cggaacggcg tgccatgtaa gaaaatcaat tccgattatc 19201 gaacggctca gaaaagaatt gggcctttcc ggtaccaagc cgacaactga tgatttgatg 19261 tttacggttg aaacggtatc ttgtcttggg gcatgcggcc ttgctcccgt aataacggta 19321 aatgacaagg tgtatgccga aatgaccccc gacaaagcct cagagcttat aaaacagttg 19381 agggagggag atgccgatgc ttaaaaacag agaagagttg cgaaaggccc gggagatgta 19441 ctcaagatac cttaaggcgg aaaagagaag agttcttgtt tgtgcaggca ccggctgcgt 19501 atccggcggt tccatggaga ttttcgagcg gctttcggag ttggtttcaa agagagggat 19561 ggattgccag gttgaattga aagaagaacc acacgacaat accataggca tgaaaaaaag 19621 cgggtgccat ggtttttgtg aaatgggacc ccttgtaaga attgagcctg aaggttatct 19681 gtacaccaaa gtaaagcttg aagactgtga agagattgtg gacagaacga tagtggcggg 19741 ggaacatata gaaaggcttg cctataaaca aaacggagtt gtatacaaaa aacaggatga 19801 aattcccttt tacaagaagc aaacccgtct tgtactggaa cactgtggtc aaattgactc 19861 cacatccata accgaatacc ttgcaaccgg gggatattat gcgctggaga aagcgttgtt 19921 tgacatgacc ggtgatgaaa ttataaatga aataactgaa gcaaatcttc gcggacgcgg 19981 aggaggaggt tttccggcag gacgtaaatg ggcacaggta aaaaggcaga atgcaaaaca 20041 aaagtatgtt gtgtgcaacg gagatgaagg cgatccggga gcgtttatgg acaggagcat 20101 tatggagggt gacccccaca gaatgattga ggggatgata attgcaggca ttgcctgcgg 20161 ggcgtccgag ggctatattt atgtgcgtgc agaatatcca cttgctgtgt ccagacttaa 20221 aagggccatc gagcaggcaa aagagtttgg cttgcttggt gaaaacatac tgggaagcaa 20281 ttttagcttc aatattcata taaatcgggg cgcaggtgcg tttgtttgcg gtgagggaag 20341 cgcgcttacg gcatcgattg aaggaaaacg tggcatgccc agggtaaagc cgccaagaac 20401 cgtggagcag ggcttgtttg atatgcctac ggttttaaac aatgttgaaa cctttgccaa 20461 cgttcccctt attatcaaaa acggagctga ctggtataaa tccatcggga ctgaaaaaag 20521 tccgggaaca aaagcttttg cgctgacggg caacatagaa aataccggtc ttattgagat 20581 tcccatggga acaaccttga gggaagttat atttgacatc ggcggaggaa tgaggaatgg 20641 cgcggatttt aaagccgtgc aaatcggagg cccgtcggga gggtgcctgt cggaaaaaga 20701 tttggacctt ccactggatt ttgactcact gaaaaaagct ggtgccatga ttggttccgg 20761 aggattggtt gtaatggaca gcaatacttg tatggtagaa gttgcgcgct tttttatgaa 20821 ttttacccag aatgagtcct gcggaaaatg tgttccctgc cgcgaaggta caaagagaat 20881 gctggagatt ttggaaagga ttgtagaagg aaacggccag gacggtgaca tagaacttct 20941 tttggaattg gcggacacca tttcagcaac ggcactttgc ggacttggca aagctgcagc 21001 atttcctgtt gtaagtacga ttaagaattt tagagaagaa tatgaagcac atatttatga 21061 caagagatgt cccacaggaa attgtcagaa gcttaaaacc attactattg atgcttcttt 21121 gtgcaaaggc tgctcaaagt gtgcaagaag ttgtcctgtg ggcgcaataa caggaaaagt 21181 taaagagcct tttgttatag atcaaagcaa atgtatcaag tgcggtgcat gtattgaaac 21241 ttgtgcattc cacgcaatat tggagggctg aagagatgga taacagagag tatatgttga 21301 tagacggaat tcctgttgag ataaacggtg aaaaaaacct tcttgagctt attcgaaaag 21361 cgggcatcaa gcttccgaca ttttgttacc attccgaatt gtcggtttac ggtgcctgcc 21421 gtatgtgcat ggttgaaaat gaatggggcg gattggatgc tgcatgttcc accccgccca 21481 gagcgggcat gagtataaaa acaaacactg aaagacttca aaaataccgg aaaatgattt 21541 tggagctttt gcttgccaat cactgtcggg attgtacaac ctgcaataac aacggaaaat 21601 gcaaactgca ggatcttgcg atgaggtaca atataagtca tattcgattc ccaaacactg 21661 cttcaaatcc ggatgtggac gattcttccc tttgcataac aagggaccgg agcaaatgca 21721 tactctgcgg agactgtgtt cgtgtatgca atgaagtaca gaatgtgggt gctattgatt 21781 ttgcctacag aggctctaaa atgacaatca gtacggtatt tgacaaacct atctttgaat 21841 caaattgtgt gggctgcgga caatgtgccc tggcatgtcc gacaggagca attgttgtaa 21901 aagatgatac acagaaagta tggaaggaaa tctatgataa aaatacccgg gtatcggtgc 21961 agatagctcc tgctgtccgt gttgctttag gaaaagaact tggcttaaat gacggagaaa 22021 atgccatagg aaaaattgtg gcggcactgc ggcgcatggg atttgatgat atatttgaca 22081 cgtcaaccgg ggcggatttg acggttctgg aagaatcggc agaactgcta aggcgtatta 22141 gagaaggaaa aaatgacatg cctcttttta cgtcatgctg tcctgcatgg gtaaactact 22201 gcgaaaagtt ctatcccgag cttttgcccc atgtttccac atgccgttca ccgatgcaga 22261 tgtttgcctc cataataaaa gaggaatatt caacttccag caaacggttg gtgcatgttg 22321 cagttatgcc ctgcacggca aagaaatttg aagcggcccg caaagagttt aaagtcaatg 22381 gagttccaaa tgttgattat gttctgacaa cccaggagct tgttcgaatg atcaaagaat 22441 cggggatagt attctctgaa ctggagcctg aagcaattga catgcccttt ggaacgtata 22501 caggagccgg tgtgatattt ggggtttccg ggggtgtcac tgaagcggtt ttaagaagag 22561 tggtttcgga caaatctccg acatctttca gatcacttgc ctataccggt gttcggggta 22621 tgaacggagt aaaagaagct tcggtgatgt acggtgacag aaagcttaaa gttgcagtgg 22681 tcagcgggct taaaaatgcc ggtgatttga ttgaaaggat taaagccggt gagcattatg 22741 atcttgtcga ggttatggca tgtccgggag gttgtataaa cggaggagga cagccctttg 22801 ttcaaagtga ggaaagagaa aagaggggca aggggttgta cagtgcggat aaactctgca 22861 atatcaaatc ttctgaagaa aatcctctta tgatgacact ttataaaggc attttaaagg 22921 gcagggttca tgaacttctt catgttgatt atgcttcaaa aaaggaggca aagtagtatg 22981 ttggagataa aaatttgcgt cggaagctcg tgccatttga aaggttctta taatgttatc 23041 aatgaatttc agcatcttat tgaggaaaaa gctttgcatg acaaaattga tataaaagca 23101 actttttgca tgaagcagtg ccagaagaac ggagttgcgg tagaggtcaa taatgagatt 23161 tttggcgttt tgccggaggc ggcggaggaa ttttttaaaa atgtgatttt acctaaggtc 23221 tagttacaag atataattaa taaattaaaa gaataattaa aagtgaaaag cttaattgag 23281 tatttttaat aaccaaacta aaagggcggc tttttagctg cccttttagt ttggaaaaag 23341 aaatattaat atcgttctaa aattgtaatt tcgctggtac cgaaatcaaa ggatacgatt 23401 ttctattcat catttttctt ttttaggttt actgttactt cattttttcg gagcagtttt 23461 gatttttcgg ctgtaattgt ttcaatttca taatatttaa atgttacgtt gtttgaatct 23521 gttacagaca agctgattgg ttcgatttct gatttgattg tataaggagt atctgtaaag 23581 tatggatact ttaatgactc aaggtctgat tcactcaata ggtccgcaaa atagaagcaa 23641 ttgatatatg tatcaaagtc cctggtgttt cgggcatcat aaaaagcagt tacgacatcc 23701 tgaggaaatg taagcggaga gctttgagag taatcgagtg taagtatttt ccatccggag 23761 tttgttttta aaagaactgc agtaacttca tatacagaga gggcaaatct gttgttgttg 23821 aaccttattt ttgatatctc tttatatgta aattctgcga ttagctttcc gtaaacacgt 23881 tctaaaggtt caattgtgta ttcaattctt tcgctgtaaa agcccagttt aagagcttca 23941 atatcttcct gagacaacat gtctgcagta tagaaactac tgataaactg atcaaaattg 24001 ttgttgttgc gggcatcgta catgttataa acgacatttt ccgataaatt gccatcttct 24061 gcaaaaaaac aggagttaca gtatttttta tctcctttcg atgaaaaagt ttataatttt 24121 gctattaatt ttacactata atcccataat tttcaacaaa atgtatttgt ttcagagagt 24181 gagcataata cttttatata tgtaaaataa aacaattcaa ttgtaaagag aattaaaata 24241 tagtaatata aattgtagaa gaatatagaa aagtgtgctt tgggttaata gttatgcata 24301 cacctgcaac aattgatgca aaaacatttc gtttttcttt tcgcaccaaa tcttttccgt 24361 acaataagtc ctatttcgtt gaagcattac gaaaatatat aatataaata tgctttgccg 24421 tttcctgaaa atttgattta ataatctggc ctgtgcaata attttgctta taaatttatg 24481 cttataaata ttacaaagca aataggaggt gtatatttag ttatttaatt taagtgtacc 24541 gcaacaggct gtttgcctga aattattgtt tattatcagt attttggagg ggatgggaaa 24601 ggatgagaga gaaaaaaatc ttttcaaaaa gaacaaaagc attaatagtt agttttgtaa 24661 ttcttgcttt gatggttttc cctgtcggta ctgtcaatat tagtgccgct aatgtggaat 24721 acaactatgc aaaggcgttg cagtattcca tatactttta cgatgcaaat atgtgcggta 24781 ccggggttga cgagaacgga cagtacaact ggagaggcga ctgccatgtt tatgatgcgg 24841 aacttccgct cgattctgta aacaccaata tgtccgatgc atttatcaga gagaacataa 24901 gtgtacttga tcctgacgga gacggtaaag ttgatgtttc cggcggtttt catgatgccg 24961 gtgaccatgt gaaattcggt atgcctgaag catattccgg ttccacactg ggatggggat 25021 attatgaatt cagggaacag tataagcaga caggacagga tcagcatatc gagacgattt 25081 tgcgttattt taatgattat ttcatgagat gtactttcag agataaagac ggcaatgtag 25141 ttgcgttttg ttatcaagtg ggtgacggtg acattgacca tgcttactgg aatccacctg 25201 aaattgatga tatgttccgt agaggatggt ttgccactaa acatttgcct tcaacggatt 25261 gcgtgtccgc agctgctgct tctcttgcag taaactattt caacttcaaa gatacagacc 25321 ctgaatatgc cgaaaaaagc cttgactatg caaaagcatt gtttgacttt gcacaaaaaa 25381 atgacaaaga agttaatgca gacggtccta aaggatatta tacttcttca aaatggcagg 25441 atgactactg ctgggctgcg gcatggcttt accttgcaac ccaggatgac aattatttga 25501 atgaactgtt taagtattat gattattatg caccttcctg ctggactcac tgctggaatg 25561 acgtttgggc aggtacggca tgcattttgg ctcaaataga cgatctttac gacaaagaca 25621 gcgaggagtt tgaaaacagg tacagacagg ctgcaaataa gagtccttat gaaccgatag 25681 atttttgggc cgaggttgca aaactggtag agaactggat gtacggtaag actgttacaa 25741 ttactcccgg tggatatgca ttccttaaca aatggggttc ggcaagatac aacacagcta 25801 cacagtttgt agctcttgtg tatgacaaac accatggtga tgcgccttca gcatacagtc 25861 aatgggcaag gtcgcaaatg gagtacctta tgggaaacaa tcctcttaat cgttgctaca 25921 ttgtaggata cagcgatatt tccgtaaaat tcccgcacca tagggcggca tcaggtttgt 25981 caaaatgtga agaccctgat cctcacaaat atgtattgta tggtgcgctg gtcggcggac 26041 cggatgagaa tgaccaacat atagatatga catcagactg ggtttacaat gaagttacaa 26101 tagactacaa tgctgctttt gttggtgcat gtgccggcct ttacagatac tttggggatc 26161 cttcaatgga gattacacct aatttcccgc cgaaggtcga gatatcggac cctgacaacg 26221 gaggttccta ttgggtagaa gcatttggtg tggacatagt acaaagcgat ggaccaaaag 26281 caactgaagt cactttgtat gtacgttcgg attcaaggaa accgtcaaag aatatttccg 26341 tcaggtactt cttcgatgcc acggggatgt catcggttga ccctgacaag atggagataa 26401 gacagcttta tgaccagaca gcggcagaga cggattatgc ggccaaactt acaggtcctc 26461 accattataa agataatatt tactatgtgg aaatatcgtg ggaaggattt gcaatcgcta 26521 attccaataa aaaataccag tttgcgttgg gtacatacac atggggcaac agttgggatc 26581 cgaccgacga ctggagttat caggaattga agatagaaga gagtaattat acaggaactc 26641 ctgcgagaaa caacagaata tgtgtttatg atgccggtgt tcttgtggga ggaattgagc 26701 cggacggaac aacacctcaa tcacctactc cgtcgccgac tcccacacct ccacaggaac 26761 cggaattcac atatggagat ttaaacgggg acggcagggt taattcatca gacttggctt 26821 tgatgaagag gtatgtggtt aaacaaattg agaaattaaa tgttccggta aaagcagctg 26881 accttaatgg agacgataaa gtaaattcaa ccgattattc agtcttaaag agatatttgc 26941 tccgttcaat cgaggttatt ccgataaaat aaaagctgaa taccaaaatg aaagacgaag 27001 gctgcccttt tttgggcggt cttctttttt attatcttat gtctcaaata tatctcaaac 27061 acaaacaggc atattttgca tatcttatta gtgggttacg caaactattt taagaatcaa 27121 tttaaatgga gggactttgc atgacaaaag gcagaataag gcacatgttt ccgggaggta 27181 acacttcaca gggctttttc agctattatg attatatatt aggccaggag gaagccaata 27241 gaattatatg tattaaaggc ggtcccggtg tcggaaagtc aacattcatg aagaaaatag 27301 gaaaagagat ggtggaaaga ggatatgacg tggaatttat gcactgttca agtgataaca 27361 acagccttga cggtgtggta ataccgtcac tgaaaatagc tcttctcgac ggaacggctc 27421 cccatgttgt ggatcctaaa aatcccggag cggtagatga gataatacat ctcggtgact 27481 tctggaacga aaaagagcta agaaagaaca aggaaggcat attaagggac aataaagagg 27541 tgggaagaac gttcagaagg gcatacagat atataaaagc tgcctatttt atatatgagg 27601 acaatatgga aatagtgagc cggtgcatgg acaacgcaaa agtaaacaaa ctctccgata 27661 ggcttaaaga cgaaattatg ggcgacaagg acattgcgga ccggcagggc agggatagaa 27721 aactttttgc aagtgcaatc actccgaacg gacttgtaaa ctatcttgat acgctgatta 27781 atacagataa ggtgtatgtt ctcaaaggta tgccgggaac agggactgaa agagtgattc 27841 aaaagataaa ggaagcggct gtggaaagag gttatgatgt tgaatctttt tattgcgcac 27901 taaatccgta taagttggaa catcttataa tacctggttt gaatgtttca ataactacgt 27961 caaatgatta tcacagtgcc aatgtggaaa acaccgctga gtataacctt gatgaatatt 28021 tggatatgac ggaattggga aaatatcagg aaactttgga aaataacaaa aagaattttg 28081 aaatgttact tgacacagct ataaaaacca ttgcaaaagc aaaagcattt catgacagta 28141 tggaaaacta ttacataccc aatatggatt ttgatgcggt ggaaagatgc tatgaagcta 28201 ctttgaacag gattcttgaa tatgcaaaag agtgtcactg aatatagatt aaaggagtcg 28261 gaattatttt gactcctttt tttacgagtc ttgaacatga tttgaagtct gtgatacaat 28321 ataataaaat aaaagttgga acaacaaaca gatttatact gtcccctata tatttgattg 28381 cttttttatt tttatccgca atttcgtcaa atgctttatt ttttacggat acaagggggt 28441 atactgtgaa aaggaaaatt ttgattgtgt ttgtactgct gtcaattgca atttcccagt 28501 ttttgtattt tgaagtggga tgttttgatg tttatgcctg gaataaggca gttattggag 28561 atgtaaatgc ggacggtgtt gtaaatatca gtgattatgt acttatgaag agatatattc 28621 tccgtattat tgcagatttt cctgctgacg atgatatgtg ggtcggagat gtaaacggag 28681 ataatgttat caacgatatt gactgtaatt atttgaaaag atatttactt catatgatta 28741 gggaatttcc gaagaactct tacaattcgg cacctacatt tacgcccata ccgacattta 28801 caccgacacc gacgccgaca aaggcacctg ccgctcctgc aaatacacaa tccggcattt 28861 tgaatgacgg atattttcct ccgggaactt cgaagcatga acttatagca agggcttcaa 28921 gtctaaaagt gagtgaagtt aaagccatta taaaaaagca ggtggatgaa cactgggatg 28981 ttataaggga cgtgtgtggg tttaagaata aagaagttgc ttatgcgttt ttctttggaa 29041 tggctaccag agagtccact tttagagctg caactgagac cggaagcggg gcttcacacg 29101 cttttggccc tttgcagaca gccgagacgg cttatgcaaa tgcgaatccc aactacatgc 29161 ccgagcataa tgttccggag atgcaccaat atgattttac ggaatacaac ttctatgatg 29221 tgggtatatc cgtacatatg ggaatcagac attttttgca ctttgcaaga cttgcgaagg 29281 aaaaatacag cggcagggac atagcgcgtc acggcttgat gggatacaat acaggttgga 29341 ttgacggtgc ggacgaatct tggattgtaa gatatgcgga tgaaactgct gctttggggg 29401 catggtatct taggaacaat catatgtccg atgatgagtt tacatgggat accgatccga 29461 gggtggatcg cagcaatcca tgggagattt attactaatt gccgtaaagc agtgaagcaa 29521 cattgtttag accgtttagg ggatgaggga gccggttttg cgcctaaatc ccctcatcta 29581 tttgacctga agcggcaaaa atataaaaac aaaagtctga gaatatttga aaaaatttaa 29641 agtacataac cggtaggttg gattttttat agagaaatta ttttttgagg tttaaaataa 29701 tatattaatg aggtttaaaa tattgtatta aaatgatatt atttatttat atgttgtata 29761 ttgcatagaa aagaatacat cattaaagag caaaggtagg ttgttatttt gggaattttc 29821 aatatatata cactgttcgg agacagaaaa agcaaggctg aaaagttgtc caaaaaagga 29881 gacgaattgt ttctgaacaa taagtatgcc gaatctgtga actattacaa aaaggcaata 29941 aaaacatatg ccaaatattt tgaagcttat gtaaacttag gttatacatt gataatattg 30001 ggaaaatatg aagagtgtat aaggtattgc aacagggcat tggctcttaa tcctcaggat 30061 gcttcggagt tgtattttat aaaggctgaa tgcttcaaaa aaatgaagag atatcgtgaa 30121 gctctggaga attatataaa ggcggttgaa ataaggaaga gggttttcta tttgattcca 30181 ctggcaattc ttctttatga tatggaggaa tatgacaagg ctctggagat atttgacact 30241 cttgaagcat tagaccttaa atataatgat gatttggaaa gtatattcct ttacaaaggt 30301 aagataatgg aaaagaaagg ccgtttcaaa gaagctatag attactttga caaggctctt 30361 gaggttaatc ctgcaaatgc ggagatatat gataaaaaag cttcttcttt gtattatctg 30421 ggcagagata cggatgacat ggatcttata aaggaatcaa taatatatta tcgaaaagcg 30481 ctggagatag acggtgaata tttgcactca ttaaacggaa ttgcagtttc tcttgaggtg 30541 ttgggaaatg ccgatgaagc tttgatttat tatgataaag cactcgaagt ttatcctgat 30601 tttgtacttg tccattacaa caaggcaaat ttgttgatga atttaagcag aaatgaagag 30661 gctttatatc attatgacaa ggcaatacag atagaccggt attgtgttga tgcctacatc 30721 gaaaaagcgg aattgctttg caagatggaa aagtacgctg acgctttgaa agtgttggat 30781 aatattttga atattgtaga agcttccgat atcagagaca gaaatgagaa aatatgcaca 30841 ttgttaaagt gcaagggtga agcgtttcat atcatgggta aatttaacga agctattgag 30901 tgctatgaca aagctcttgc agttgataaa gacagagcgg atgttcttgt gaaaaagggg 30961 gaagcttata atcgtttggg aatgcctcaa gaggcaattc ttatgtacga aaaagcactc 31021 ggggtgagaa atgactatta tatagcctat tttttaatgg gagttacata caagcattta 31081 gatgagtacc aattggcact tgaagctttt gattgttata taaatgctgt gcctaaagta 31141 cctgaagctt atgtggagag ggctgaagta ctgcaattta tgcaaaggta tgaggaggca 31201 aaggaagatt gcgaccaagc ccttgtgttg aggccacagt ttggaagtgc atgttacagg 31261 aagagcctta ttttatgtga acttggcaaa tatgatgagg caatagaaat tctcgaaaaa 31321 ctgctcgatg atgaagagtt ttgtgatatt gcaggatatt tcaagggtgt tgcgctgaaa 31381 aatctgggaa ggtatgaaga agctttggaa tatgtggatg gatatataac aaaatatccc 31441 ggatacagag aaccctatct tgaaaaagct gatattttga ttgctcttga agaatacgaa 31501 aaagccatgg aggcctgtaa cgttctgctt gacagggatg ctgaagatat cggtgctttg 31561 gtaaaaaaga gcggtgtgtt tttcagacag gataaattcg aagaggctct taaatgtatt 31621 gaagatgcca tggctttatc tttggaccat catgctttgt actactacaa agcagaaata 31681 ctgaggaata tggggaaacc tgaggaggct atagagtttt ttgacaaata tattgagaaa 31741 gttcccaacc accccaatcc ttatattggc cgtgcgaagt cgttatatgt aatgcaggaa 31801 tatgagaaag ccctggaatg ctgtgaaaag gcaataagtc ttgatgacaa atatattgaa 31861 ggttattatt caaaagcgca catattgctg cagatggaca aatatgagga tgtcctggaa 31921 ctgttggata aaataaagga aattgatccg gagtttccta tgttttatta tgaccgggct 31981 gaagttttca aaagaatggg aaatcacgaa aaagcgcttc aggaaatcga tatttatctt 32041 gagaaatttc cggacgacgg ctatgcccat gaaaaaaggg ccaatatcct gtttactttg 32101 ggaagacttg acgaggccat cgaggaatgc gacaaggcca tcgagtttga acccgagctg 32161 ttagatgctt actacgggaa gggatacata ctttattata caggacggtt taaagagtcc 32221 ttaagctatt ttgacaaggt aattgagtta aattccaaaa gtgcttatgc ttattacagc 32281 aagggaaatg cccttaaata tttgggagac tttgaaggcg ctttggaaaa ttacaactat 32341 gccataaatt tgtggcatga atttgctgag tgttattcgg ccataggtca tctttatttc 32401 ctggtgggta attatacaaa cagtatgatt ttctacgaca gggctgagag tctaaaaccg 32461 gattatattt atccatatat aggaaaatcc cagctgtata tgacgctggg cgacatggaa 32521 agtgccataa ggtatagtga caaagctttg gaaatatctc ctgatgatgc ggaggtacac 32581 aataacaagg gtaagattct ggggtatttt ggaatgtttg atgaagcagt cagctctttt 32641 ctgactgcaa ttgaactaaa tgacagtcag gcggaatatt attataatct gggaaatgcc 32701 tatcttatga taaatgagtt tgaaaatgcg atagaaagct ataacaaggc tataaatttg 32761 tatccggagt atgaagccgc ctacgttgga atcggcaagg cgcagatgtg ccttgaaaat 32821 attgaagaag cactgaagaa ttttaacaaa gccatagaat tgaatccgcg ttctgccgaa 32881 gcatattatt caaaatccga ggctttaaga atactggacg aggaagaaga agcgcaggag 32941 tgctatgaaa aggctttgga gcttgggtat aatgcatagg aaaacttaat attggttctc 33001 ttgaaaggag agaatggttc ttatgaatgg aataaagaaa ttcaaatgga ttattggtac 33061 tacttctatt attcttgttg cttttttagc agtggttatg aactcagata aatggggaag 33121 tggagcggta tcagcatatg gaaaggtatc gcaggatgca atagaagttt cgttgataaa 33181 tttgattgcc acgccggaac agtatgacgg gaaattagta agggttacag gagtggcaac 33241 agttgaattt gaaaacagtg gcctatatct ttcaagagat gattataaaa atgcgataac 33301 gaaaaatgct gtttgcttga cattggatga gaaattgctt ggaacaacat atgaaaatct 33361 taaaaaaacg aacggaaagt atgttttggt tgaaggtatt tttaacggca aggaaaaagg 33421 ccattttgac aggtgttctg gaacaattga taacattaca aggtacgagg tttggaagta 33481 gcttaaatca ccattgaaat ttcatgtttt ttaccgcatc cggatactaa atgacatatc 33541 cctgatagtt caattctgtc agggattttt tattttgtga acagatacaa aatgttattg 33601 taaagctgca aagtacctgt ccaataaaaa aatattgggg tcaaatttca aaaatattcc 33661 actgattgat atataacgat gcatataaaa tccccggtaa aattactagt tgaagatatt 33721 ttttatataa ttacaaaatt cgacaaaaaa tgtatttgca ataggatatt tttatgctaa 33781 aatttcaaag aaattttggt aagtattatc tttttaaggg atatgtacaa atgagaaaga 33841 ttaaaattat taattatttc cctttgtttt tcatgctctt tattgtaatt ttgcgtgtct 33901 tttttgtttc aagttcggct gaagtggcta atactgcaga tacaaatatt aaattgctgc 33961 agaatagtga ggctcctttt aaatatggtg atttaaatgg tgacaataat ataaatagca 34021 gcgactatac tttgctaaaa agatatttgc ttcatacgat aagagaaagc ccagaaaaac 34081 gtccgcaccc tcatttcggt gaaaaatatt ctggtgtcga caatttatct aacctgattg 34141 atttaagcta cttgaaatga taagtttaga atatttttta acagtatata atattaggaa 34201 tattaggagg gagagaaaag aga //