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Rastegar Epigenetics & Stem Cell Neurogenesis Lab |
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Rastegar Epigenetics & Stem Cell Neurogenesis Lab |
| Current Projects |
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| The focus of our lab is
to understand the epigenetic control of stem cell neurogenesis. Our aim
is to elucidate the molecular mechanisms of stem cell differentiation
by investigating the role of specific genes and epigenetic
modifications during Embryonic Stem (ES) cell and Neural Stem Cell
(NSC) neurogenesis. Different projects in the lab address: 1. HOX Regulatory Network during NSC Neurogenesis 2. Epigenetics of ES Cell Neurogenesis 3. Epigenetics in Human Disease; Studying MeCP2 Isoform-specific targets for Rett syndrome Our ultimate goal is to explore the potential of stem cell differentiation towards generating specific cell types for treatment of neurological disorders in Regenerative Medicine. Overall, our lab studies a very basic question, how a cell makes the decision to differentiate into a neuron and to define the genomic and epigenomic basis for its neuronal fate. A comprehensive molecular knowledge of neurogenesis will enble us to develop novel strategies for generating specific types of neurons. We aim to move towards controlled stem cell programming and differentiation. The future translation of our work is for patients with neurological disorders associated with disabilities.
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| Copyright © 2010
Mojgan Rastegar. All rights reserved. Site Design by Skye Rousseau. |