LAST UPDATE: September 2013

Dr. Frank Schweizer
Associate Professor
Departments of Chemistry
and Medical Microbiology
University of Manitoba
Winnipeg, MB
R3T 2N2

Office:460 Parker
Labs: 448 & 446 Parker

Tel: (204) 474-7012
Fax: (204) 474-7608

Refereed Articles

68. Zhanel, G.G., Adam, H.J.; Baxter, M.R.; Fuller, J.; Nichol, K.A.; Denisuik, A.J.; Lagac é -Wiens, P.R.; Walkty, A.; Karlowsky, J.A.; Schweizer, F.; Hoban, D.J.; Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study. J. Antimicrob. Chemother. 68, Suppl 1: i7-22 (2013).
67. Findlay, B.; Mookherjee, N.; Schweizer, F. Ultrashort lipopeptides and lipopeptoids selectively induce cytokine production in macrophages. PLos One 8 e54280 (2013).
66. Zhanel GG, Lawson CD, Adam H, Schweizer F, Zelenitsky S, Lagac é -Wiens PR, Denisuik A, Rubinstein E, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA. Ceftazidime-avibactam: a novel cephalosporin/ β -lactamase inhibitor combination. Drugs, 73, 159-177 (2013).
65. Naziga, E.B.; Schweizer, F.; Wetmore, S.S. Solvent Interactions stabilize the polyproline II conformation of glycosylated oligoprolines. J. Phys Chem B 117, 2671-81 (2013).
64. Xu, Y.; Ogunsina, M, Smadder, P.; Arthur, G.; Schweizer, F. Structure-activity relationships of glucosamine-derived glycerolipids; the role of the anomeric linkage, the cationic charge and the glycerol moiety on the antitumor activity. ChemMedChem 8, 511-520.
63. Jain, M.V.; Paczulla, A.M.; Klonisch, T.; Dimgba, F.N.; Rao, S.B.; Roberg, K.; Schweizer, F.; Lengerke, C.; Davoodpour, P.; Palicharla, V.R.; Maddika, S.; Los, M. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J. Cell. Mol. Med. 17, 12-29 (2013).
62. Teklebrhan, R.B.; Owens, N.W.; Xidos, J.D; Schreckenbach, G.; Wetmore, S.D.; Schweizer, F. Conformational preference of fused carbohydrate-templated proline analouges - a computational study. J. Phys. Chem B 117, 199-205 (2013).
61. Kanaya, T., Schweizer, F., Takeda, T.; Kiuchi, F., Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids and related carbohydrate moieties form the parasite Schistosoma mansoni.
Carbohydr. Res. 361, C55-72 (2012).
60. Bera, A., Dhondikubeer, R., Findlay, B., Zhanel, G.G., Schweizer, F. Synthesis and antibacterial activities of amphiphilic neomycin B-based bilipid conjugates and fluorinated neomycin B-based lipids. Molecules 9129-9141 (2012).
59. Koizumi, A.; Yamano, K.; Tsuchiya, T.; Schweizer, F.; Kiuchi, F.; Hada, N. Synthesis, antigenicity against human sera and structure activity relationships of carbohydrate moiety from Toxoara larvae and its analogues. Molecules 17(8), 9023-9042 (2012).
58. Findlay, B., Szelemej, P., Zhanel, G.G. Schweizer, F. Guanidinylation and tail effects in cationic antimicrobial lipopeptoids. PLoS ONE 7, e41141 (2012).
57. Dhondi, R., Bera, S., Zhanel, G.G., Schweizer, F. Antibacterial activity of amphiphilic tobramycin. J. Antibiot. 65, 495-498 (2012).
56. Zhanel, G.G., Schweizer, F., Karlowsky, J.A. Oritavancin: Mechanism of action. Clin. Infect. Diseases 54, Suppl 3; S214-219 (2012).
55. Findlay, B., Zhanel, G.G.; Schweizer, F. Investigating the antimicrobial peptide "window of activity" using cationic lipopeptides with hydrocarbon and fluorinated tails. Int. J. Antimicrob. Agents 40, 36-42 (2012).
54. Zhanel, G.G., Lawson, C.D., Zelenitsky, A., Findlay, B., Schweizer, F., Adam, H., Walkty, A., Rubinstein, E., Gin, A.S., Hoban, D.J., Lynch, J.P., Karlowsky, J.A.. Comparison of the next generation aminoglycoside plazomicin (ACHN-490) to gentamicin, tobramycin, and amikacin. Exp. Rev. Antiinfect. Ther. 10, 459-473 (2012). .
53. Findlay, B., Zhanel, G.G., Schweizer, F. Neomycin-phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low haemolytic activity and weak serum protein binding. Bioorg. Med. Chem. Lett. 22, 1499-1503 (2012).
52. Naziga, E.B., Schweizer, F., Wetmore, S.D. Conformational study of the hydroxyproline-O-glycosidic linkage: Sugar-peptide orientation and prolyl amide isomerization in (α,β)-galactosylated 4(R/S)-hydroxyproline. J. Phys. Chem. B. 116, 860-871 (2012).
51. Koizumi, A., Yamano, K., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N. Synthesis of the carbohydrate moiety of the parasite Echinococcus multilocularis and their antigenicity against human sera. Eur. J. Med. Chem. 46, 1768-1778 (2011).
50. Mondal, D., Zhanel, G.G., Schweizer, F. Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants. Carbohydr. Res. 346, 588-594 (2011).
49. Bera, S. Zhanel, G.G., Schweizer, F. Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates. Carbohydr. Res. 346, 560-568 (2011).
48. Fujita, Y., Ohshima, N., Hasegawa, A., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N., Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues. Molecules 16, 637-651 (2011).
47. Zhanel, G.G., Decorby, M., Adam, H., Mulvey, M.R., McCracken, M., Lagacé-Wiens P., Nichol, K.A., Wierzbowski, A., Baudry P.J., Tailor, F., Larlowsky, J.A., Walkty, A., Schweizer, F., Johnson, J., Hoban D.J. Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian ward surveillance study (CANWARD 2008). Antimicrobial Agents Chemother. 54, 4684-4693 (2010).
46. Teklebrhan R.B., Zhang, K., Schreckenbach, G., Schweizer, F., Wetmore, S.D. Intramolecular hydrogen-bond controlled prolyl amide isomerization in glucosyl 3(S)-hydroxy-5-hydroxymethylproline hybrids: a computational study. J. Phys Chem. B 114, 11594-11602 (2010).
45. Findlay, B., Zhanel, G.G., Schweizer, F. Cationic amphiphiles: a new generation of antimicrobials inspired by the natural antimicrobial scaffold. Antimicrobial Agents Chemother. 54, 4049-4058 (2010).
44. Kanaya T, Yagi, S., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids from the parasite Schistosoma mansoni. Chem. Pharm. Bull. (Tokyo) 58, 811-817, (2010).
43. Mondal, D., Schweizer, F. Synthesis of allose-templated hydroxyornithine and hydroxyarginine analogues. Carbohydr. Res. 345, 1533-1540, (2010).
42. Bera, S., Zhanel, G.G., Schweizer, F. Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents. Bioorg. Med. Chem. Lett. 20, 3031-3035 (2010).
41. Zhang, K., Schweizer, F. Influence of glucose-templated proline mimetics on the b-turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S. Carbohydr. Res. 345, 1114-1122 (2010).
40. Bera, S, Zhanel, G.G., Schweizer, F. Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin- and neamine-based amphiphiles with potent broad-spectrum antibacterial activity. J. Med. Chem. 53, 3626-3631 (2010).
39. Owens, N.W., Stetefeld, J., Lattová, E., Schweizer, F. Contiguous O-galactosylation of 4R-hydroxy-L-proline residues forms very stable polyproline II helices. J. Am. Chem. Soc. 132, 5036-5042 (2010).
38. Bera, S. Zhanel, G.G., Schweizer, F. Antibacterial activity of guanidinylated neomycin B and kanamycin A-derived amphiphilic lipid conjugates. J. Antimicrob. Chemother. 65, 1224-1227 (2010).
37. Zhanel, G.G., Calic, D., Schweizer, F., Zelenitsky, S., Adam, H., Lagac é -Wiens, P.R.S., Rubinstein, E., Gin, A.S., Hoban, D.J., Karlowsky, J.A. Dalbavancin, oritavancin and televancin: A comparative review. Drugs 70, 859-886 (2010).