LAST UPDATE: June 2016

Dr. Frank Schweizer
Full Professor
Departments of Chemistry
and Medical Microbiology
University of Manitoba
Winnipeg, MB
R3T 2N2

Office:460 Parker
Labs: 448, 446 & 382 Parker

Tel: (204) 474-7012
Fax: (204) 474-7608

Refereed Articles

1. Akbari-Birgani, S., Paranjothy, T., Zuse, A.; Janikowski, T.; Cieslar-Probuda A, Likus, W.; Urasinska, E.; Schweizer, F.; Ghavami, S.; Klonisch, T.; Los, M.J. Cancer stem cells, cancer initiating cells and methods for their detection. Drug Discov. Today 21, 836-842 (2016).
2. Zhanel G.G.; Cheung, D.; Adam H.; Zelenitsky, S.; Golden, A.; Schweizer, F.; Gorityala, B.; Lagace-Wiens, P.R.; Walkty, A.; Gins, A.S.; Hoban, D.J.; Karlowsky, J.A. Review of Eravacycline a novel fluorocycline antibacterial agent. Drugs 76, 567-588 (2016).
3. Gorityala, B.K.; Guchhait, G.; Fernando, D.M.; Deo, S.; McKenna, S.A., Zhanel, G.G.; Kumar, A.; Schweizer, F. Adjuvants based on hybrid antibiotics overcome resistance in Pseudomonas aeruginosa and enhance fluoroquinolone efficacy. Angew. Chem. Intl. Ed. Engl. 55, 555-559 (2016).
4. Domalaon, R.; Zhanel. G.G.; Schweizer, F. Short antimicrobial peptides and peptide scaffolds as promising antibacterial agents. Curr. Top. Med. Chem, 16, 1217-1230 (2016).
5. Idowu, T, Samadder, P., Arthur, G., Schweizer, F. Design, synthesis and antitumor propterties of glycosylated antitumor ether lipids (GAEL)-chlorambucil hybrids. Chem. Phys. Lipids 194, 139-148 (2016).
6. Jain, M.V.; Jangamreddy, J.R.; Grabarekerzy, J; Schweizer, F.; Klonisch, T.; Cieslar-Probuda, A.; Los, M.J. Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1). Cell Cycle,14 2109-2120 (2015).
7. Guchhait, G.; Altieri, A.; Gorityala, B.; Yang, X.; Findlay, B.; Zhanel. G.G.; Mookherjee, N.; Schweizer, F. Amphiphilic tobramycin with immunomodulatory properties. Angew. Chem. Intl. Ed. 54 6278-6282 (2015).
8. Zhanel, G.G.; Love, R.; Adam, H.; Golden, A.; Zelenitsky, S.; Gorityala, B.K.; Schweizer, F, Lagace-Wiens, P.R.S.; Rubinstein, E.; Walkty, A.; Gin, A.S.; Gilmour, M.; Hoban, D.J.; Lynch 3rd, J.P.; Karlowsky, J.A. Tedizolid: A novel oxazolidinone with enhanced potency against multidrug-resistant Gram-positive pathogens. Drugs 75, 253-270 (2015)
9. Domalaon, R.; Yang, X.; O'Neil, J.; Zhanel, G.G.; Neeloffer, M.; Schweizer, F. Structure activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constrained on antibacterial activity. Amino Acids 46, 2517-2530 (2014).

10. Xu, Y.; Schweizer, F.; Arthur, G. Cytotoxic properties of D-gluco, D-galacto- and D-manno-configured 2-amino-2-deoxy-glycerolipids against epithelial cancer cell lines and BT-474 breast cancer stem cells. Eur. J. Med. Chem. 78, 225-235 (2014).
11. Zhanel G.G.; Chung, P.; Adam, H.; Zelenitsky, S.; Denisuik, A.; Schweizer, F.; Lagace-Wiens, P.R.; Rubinstein, E.; Gin, A.S.; Walkty, A.; Hoban, D.J.; Lynch, J.P.; Karlowsky, J.A. Ceftolozone/Tazobactam: A novel cephalosporin/
b-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs 74, 31-51 (2014).
12. Ogunsina, M.; Pan, H.; Samadder, P.; Arthur, G.; Schweizer, F. Structure activity relationships of N-linked and diglycosylated glucosamine-based antitumor glycerolipids. Molecules, 18, 15288-304 (2013).
13. Zhanel, G.G., Adam, H.J., Baxter, M.R., Fuller, J.; Nichol, K.A.; Denisuik, A.J.; Lagace-Wiens, P.R.; Walkty, A.; Karlowsky, J.A.; Schweizer, F.; Hoban, D.J. Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals; results of the CANWARD 2007-11 study. J. Antimicrob. Chemother. 68, Suppl. 1; i7-i22 (2013).
14. Zhanel, G.G.; Lawson, C.D.; Adam, H.; Schweizer, F.; Zelenitsky, S.; Lagace-Wiens, P.R.; Denisuik, A.; Rubinstain, E.; Gin, A.S.; Hoban, D.J., Lynch, J.P.
Ceftazidime-avibactam: a novel cephalosporin/beta-lactamase inhibitor combination. Drugs 73, 159-177 (2013).
15. Jain, M.V.; Paczulla, A.M.; Klonisch, T.; Dimgba, F.N.; Rao, S.B.; Roberg, K.; Schweizer, F.; Lengerke, C.; Davoodpour, P.; Palicharla, V.R.; Maddika, S.; Los, M. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J. Cell. Mol. Med.
17, 12-29 (2013).

16. Findlay, B.; Mookherjee, N.; Schweizer, F. Ultrashort Cationic Lipopeptides and Lipopeptoids Selectively Induce Cytokine Production in Macrophages. PLoS ONE 8, e54280 (2013).
17. Xu, Y.; Ogunsina, M.; Samadder, P.; Arthur, G.; Schweizer, F. Structure-Activity Relationships of Glucosamine-Derived Glycerolipids: the Role of the Anomeric Linkage, the Cationic Charge, and the Glycero Moiety on Antitumor Activity. ChemMedChem 8, 511-520 (2013).
18. Naziga, E.B.; Schweizer, F.; Wetmore, S.D. Solvent interactions stabilize the polyproline II conformation of glycosylated oligoprolines. J. Phys. Chem. B 117, 2671-2681 (2013).
19. Teklebrhan, R.B.; Owens, N.W.; Xidos, J.D; Schreckenbach, G.; Wetmore, S.D.; Schweizer, F. Conformational preference of fused carbohydrate-templated proline analouges - a computational study. J. Phys. Chem B 117, 199-205 (2013).
20. Kanaya, T.; Schweizer, F.; Takeda, T.; Kiuchi, F.; Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids and related carbohydrate moieties from the parasite Schistosoma mansoni. Carbohydr. Res. 361, 55-72 (2012).
21. Bera, A.; Dhondikubeer, R.; Findlay, B.; Zhanel, G.G.; Schweizer, F. Synthesis and antibacterial activities of amphiphilic neomycin B-based bilipid conjugates and fluorinated neomycin B-based lipids. Molecules, 17, 9129-41 (2012).
22. Koizumi, A.; Yamano, K.; Tsuchiya, T.; Schweizer, F.; Kiuchi, F.; Hada, N. Synthesis, antigenicity against human sera and structure activity relationships of carbohydrate moiety from Toxoara larvae and its analogues. Molecules 17(8), 9023-9042 (2012).
23. Findlay, B., Szelemej, P., Zhanel, G.G. Schweizer, F. Guanidinylation and tail effects in cationic antimicrobial lipopeptoids. PLoS ONE 7, e41141 (2012)
24. Dhondi, R., Bera, S., Zhanel, G.G., Schweizer, F. Antibacterial activity of amphiphilic tobramycin. J. Antibiot. 65, 495-8 (2012)
25. Findlay, B., Zhanel, G.G., Schweizer, F. Investigating the antimicrobial peptide "window of activity" using cationic lipopeptides with hydrocarbon and fluorinated tails. Int. J. Antimicrob. Agents 40, 36-42 (2012).
26. Zhanel, G.G., Lawson, C.D., Zelenitsky, S., Findlay, B., Schweizer, F., Adam, H., Walkty, A., Rubinstein, E., Gin, A.S., Hoban, D.J., Lynch J,P., Karlowsky, J.A. Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin. Expert Rev. Anti Infect. Ther. 10, 459-473 (2012).
27. Zhanel, G.G., Schweizer, F., Karlowsky, J.A. Oritavancin: Mechanism of action. Clin. Infect. Dis. 54, Suppl 3; S214-219 (2012).
28. Findlay, B., Zhanel, G.G., Schweizer, F. Neomycin-phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low haemolytic activity and weak serum protein binding. Bioorg. Med. Chem. Lett. 22, 1499-1503 (2012).
29. Naziga, E.B., Schweizer, F., Wetmore, S.D. Conformational study of the hydroxyproline-O-glycosidic linkage: Sugar-peptide orientation and prolyl amide isomerization in (alpha/beta)-galactosylated 4(R/S)-hydroxyproline. J. Phys. Chem. B. 116, 860-871 (2012).
30. Koizumi, A., Yamano, K., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N. Synthesis of the carbohydrate moiety of the parasite Echinococcus multilocularis and their antigenicity against human sera. Eur. J. Med. Chem. 46, 1768-1778 (2011).
31. Mondal, D., Zhanel, G.G., Schweizer, F. Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants. Carbohydr. Res. 346, 588-594 (2011).

32. Bera, S. Zhanel, G.G., Schweizer, F. Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates. Carbohydr. Res. 346, 560-568 (2011).
33. Koizumi, A., Yamano, K., Schweizer, F., Takeda, T.; Kiuchi, F., Hada, N. Synthesis of the carbohydrate moiety from the parasite Echinococcus multilocularis and their antigenicity against human sera. Eur. J Med, Chem. 46, 1768-1778 (2011).
34. Fujita, Y., Ohshima, N., Hasegawa, A., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N., Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues. Molecules 16, 637-651 (2011).
35. Zhanel, G.G., Decorby, M., Adam, H., Mulvey, M.R., McCracken, M., Lagace-Wiens P., Nichol, K.A., Wierzbowski, A., Baudry P.J., Tailor, F., Karlowsky, J.A., Walkty, A., Schweizer, F., Johnson, J., Hoban D.J. Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian ward surveillance study (CANWARD 2008). Antimicrobial Agents Chemother. 54, 4684-4693 (2010).
36. Teklebrhan R.B., Zhang, K., Schreckenbach, G., Schweizer, F., Wetmore, S.D. Intramolecular hydrogen-bond controlled prolyl amide isomerization in glucosyl 3(S)-hydroxy-5-hydroxymethylproline hybrids: a computational study. J. Phys Chem. B 114, 11594-11602 (2010).
37. Findlay, B., Zhanel, G.G., Schweizer, F. Cationic amphiphiles: a new generation of antimicrobials inspired by the natural antimicrobial scaffold. Antimicrobial Agents Chemother. 54, 4049-4058 (2010).
38. Kanaya T, Yagi, S., Schweizer, F., Takeda, T., Kiuchi, F., Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids from the parasite Schistosoma mansoni. Chem. Pharm. Bull. (Tokyo) 58, 811-817, (2010).
39. Mondal, D., Schweizer, F. Synthesis of allose-templated hydroxyornithine and hydroxyarginine analogues. Carb. Res. 345, 1533-1540, (2010).
40. Bera, S., Zhanel, G.G., Schweizer, F. Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents. Bioorg. Med. Chem. Lett. 20, 3031-3035 (2010).
41. Zhang, K., Schweizer, F. Influence of glucose-templated proline mimetics on the
b-turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S. Carb. Res. 345, 1114-1122 (2010).