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Contact
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480 Parker Building
144 Dysart Road
R3T 2N2 Winnipeg
Manitoba, Canada
phone: 1-204-474-9731
fax: 1-204-474-7608
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Teaching
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Lectures (CHEM)
2007-09
Biochemistry (2370)
2008
X-Ray Crystallography (4570)
2009-2012
Signal Transduction (4360)
2010-2011
Advanced Biochemistry (4700)
Grad Course (CHEM)
2008
Structure Based Drug Design
2009
Protein X-Ray Crystallography
2009-2010/ 11-12
Biophysical Chemistry (7400)
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| The Lab |
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The primary goal of our research is to understand
in detail the structure-function relationship of proteins as dynamic
systems. We are mainly focused on signaling linked to
catalytic turnover, the storage function of
coiled-coil domains and mechanisms of complex formations and signal
transduction within the extracellular matrix. To reveal the structural and functional basics
of the underlying molecular aspects of signaling, we use a
combination of:
- X-ray crystallography (in combination with SAXS and XPS), solution NMR and Electron Microscopy
- several biophysical techniques (a.o. CD-spectroscopy, DLS, AUC, ITC, DSC and FRET)
- In vitro functional analysis (molecular
biology and biochemistry)
Our long term goal is to develop a molecular
understanding of target proteins at work. The research will provide new
insights into basic mechanisms of how these proteins function, and
applied science of great biotechnological and biomedical importance
will be advanced.
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Recent Research Highlights |
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Booy EP, Meier M, Okun N, Novakowski SK, Xiong S, Stetefeld J, McKenna SA.
The RNA helicase
RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and
promotes the formation of the P1 helix template boundary.
Nucleic Acids Res. 2011
Patel TR, Reuten R, Xiong S, Meier M, Winzor DJ, Koch M, Stetefeld J.
Determination of a molecular shape for netrin-4 from hydrodynamic and small angle X-ray scattering measurements.
Matrix Biology 2011
Sorensen JL, Stetefeld J.
Kinemage of action - proposed reaction mechanism of glutamate-1-semialdehyde aminomutase at an atomic level.
Biochem Biophys Res Commun. 2011
Patel TR, Morris GA, Zwolanek D, Keene DR, Li J, Harding SE, Koch M, Stetefeld J.
Nano-structure of the laminin γ-1 short arm reveals an extended and curved multidomain assembly.
Matrix Biology 2010
Campbell Kl, Robberts JEE, Watson LN, Stetefeld J, Sloan AM Signore
AV, Howatt JW, Tame JRH, Rohland N, Shen TJ, Austin JJ, Hofreiter
M, Ho C, Weber RE and Cooper A
Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance
Nature- Genetics 2010
Orriss G, Patel T, Sorensen J and Stetefeld J
Absence of a catalytic water confers resistance to gabaculine
FASEB Journal 2010
Eble JA, Niland S, Bracht T, Mormann M, Peter-Katalinic J, Pohlentz G, Stetefeld J.
The alpha2beta1 integrin-specific antagonist rhodocetin is a cruciform, heterotetrameric molecule.
FASEB Journal 2009
for a complete list in Life Science Publications see PUBMED
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Group Members |
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Markus Meier, PhD
Research Associate
+1-204 474-9731
meier"at"cc.umanitoba.ca
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George Orriss, PhD
Research Associate
+1-204 474-7172
orriss"at"cc.umanitoba.ca
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Matthew McDougall
PhD-student
+1-204 474-7172
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Jörg Stetefeld, PhD
Principal Inspirator
+1-204 474-9731
stetefel"at"cc.umanitoba.ca
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Trushar Patel, PhD
CIHR-PDF
+1-204 474-7172
patelt"at"cc.umanitoba.ca
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Natalie Okun
Undergraduate Project Student
+1-204 474-7172
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Evan Wiens
MSc-student
+1-204 474-7172
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Oksana Marushchak
PhD-student
+1-204 474-7172
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Keeley Edwards
Honours Project Student
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Brigitte Baragar
Undergraduate project Student
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We will never forget |
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M. Aziz ("Dr. Bradford"); NSERC-USRA Student [2006-2008]
A. McFarlane MSc/ PhD-student [2007-2011]
A. Hrabowych NSERC-USRA Student [2008-2010]
C. Viddal PhD; NSERC-PDF [2008-2010]
S. Karrasch, PhD; Research Associate [2008-2011]
L. Tapley NSERC-student [2009/10] and MICH-student [2011]
E. K. Ogbomo ("Master Kelly"); MSc Student [2009-2010]
S. Gajjeraman, PhD; Research Associate [2009-2010]
G. Cox; Project student (Red River College) [2011]
C. Ezeonwuka USRA student [2011]
S. Xiong NSERC Student [2011]
I. Xie Guest student (McGill University) [2011]
A. Peters Guest Student (Uni Greifswald) [2012]
T. Taylor Project Student (Red River College) [2012]
W. Kim VP Research Award Student [2012]
K. Edwards VP Research Award Student [2012]
B. Baragar Project Student [2012]
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