© Dr. Aleksandra Glogowska Research 2016
Dr. Aleksandra Glogowska
Research
Research
Dr. Glogowska is interested in studying the effect of proEGF like ligands in the ubiquitin-proteasome system in brain cancer. Her PhD work showed important function of pro EGF domains in regulation of proteolytic degradation of ErbB1/2 effecting major cell cycle molecules and leading to inhibition of cancer cells proliferation and migration. Over-expression of EGFR in brain tumors (oligodendrogliomas, glioblastomas) identifies them as targets for the actions of EGF-like ligands. Pro EGF has been known to affect tumor cell growth, differentiation and metastasis. Amplification and ligand-induced activation of EGFR correlates with increased in-vitro tumor cell migration, matrix degradation and enhanced in-vivo tissue invasiveness. Knowledge of the regulatory mechanisms that control the function of ubiquitin-proteasome system is critical to design new or used existing inhibitors with the aim of inducing ubiquitin-proteasome system related anticancer effect.
