2024
- Asakereh I, Rutbeek NR, Singh M, Davidson D, Prehna G*, Khajehpour M*. The Streptococcus phage protein paratox is an intrinsically disordered protein Protein Sci. 2024 Jun;33(6):e5037. doi: 10.1002/pro.5037. *Co-corresponding author
- Agbavor C, Zimnicka A, Kumar A, George JL, Torres M, Prehna G, Alonzo F 3rd, Durrant JD, Freitag NE, Cahoon LA. The chaperone PrsA2 regulates the secretion, stability, and folding of listeriolysin O during Listeria monocytogenes infection mBio. 2024 May 29:e0074324. doi: 10.1128/mbio.00743-24.
- Sychantha D, Chen X, Koteva K, Prehna G, Wright GD. Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes Nat Commun. 2024 May 13;15(1):4036.doi: 10.1038/s41467-024-48232-1.
- Penner TV, Lorente Cobo N, Patel DT, Patel DH, Savchenko A, Brassinga AKC, Prehna G Structural characterization of the Sel1-like repeat protein LceB from Legionella pneumophila Protein Sci. 2024 Mar;33(3):e4889. epub Dec 31 2023 doi: 10.1002/pro.4889.
- Maydaniuk DT, Martens B, Iqbal S, Hogan AM, Lorente Cobo N, Motnenko A, Truong D, Liyanage SH, Yan M, Prehna G, Cardona ST The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling Microbiol Spectr. 2024 Feb 6;12(2):e0320123 epub: Jan 11 2024 doi: 10.1128/spectrum.03201-23.
- Lorente Cobo N, Sibinelli-Sousa S, Biboy J, Vollmer W, Bayer-Santos E, Prehna G Molecular characterization of the type VI secretion system effector Tlde1a reveals a structurally altered LD-transpeptidase fold J Biol Chem. 2022 Sep 29;102556. doi: 10.1016/j.jbc.2022.102556
- Bullen NP, Sychantha D, Thang SS, Culviner PH, Rudzite M, Ahmad S, Shah VS, Filloux A, Prehna G, Whitney JC. An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs Mol Cell. 2022 Aug 31 doi: 10.1016/j.molcel.2022.08.015
- Culp EJ, Sychantha D, Hobson C, Pawlows AC, Prehna G, Wright GD. ClpP inhibitors are produced by a widespread family of bacterial gene clusters Nat. Microbiol. 2022 Mar;7(3):451-462.doi: 10.1038/s41564-022-01073-4
- Rutbeek NR, Rezasoltani H, Patel TR, Khajehpour M, Prehna G. Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox. J Biol Chem. 2021 Jul 21;297(3):100992. doi: 10.1016/j.jbc.2021.100992.
- Ahmad S, Tsang KK, Sachar K, Quentin D, Tashin TM, Bullen NP, Raunser S, McArthur AG, Prehna G*, Whitney JC*. Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones Elife. 2020 Dec 15;9:e62816. doi: 10.7554/eLife.62816. (*indicates co-corresponding author)
- Inniss NL, Prehna G*, Morrison DA*. The pneumococcal σ(X) activator, ComW, is a DNA-binding protein critical for natural transformation. J Biol Chem. 2019 Jul19;294(29):11101-11118. doi: 10.1074/jbc.RA119.007571. (*indicates co-corresponding author)
- Mashburn-Warren L, Goodman SD, Federle MJ, Prehna G. (2018) The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus. Sci Rep. Nov 8;8(1):16535. doi: 10.1038/s41598-018-34816-7
- Oguri T, Kwon Y, Woo JKK, Prehna G, Lee H, Ning M, Won KJ, Lee J, Mei S, Shi Y, Jeong H, Lee H. (2018) A family of small intrinsically disordered proteins involved in flagella-dependent motility in Salmonella. J Bacteriol. Oct 29.doi: 10.1128/JB.00415-18.
- Neiditch MB, Capodagli GC, Prehna G, Federle MJ. (2017) Genetic and Structural Analysis of RRNPP Intercellular Peptide Signaling of Gram-Positive Bacteria. Annu. Rev. Genet. Nov 27;51:311-333.
- Bhide GP, Prehna G, Ramirez BE, Colley KJ. (2017) The Polybasic Region of the Polysialyltransferase ST8Sia-IV Binds Directly to the Neural Cell Adhesion Molecule, NCAM. Biochemistry. Mar 14;56(10):1504-1517.
- Rush MD, Walker EM, Prehna G, Burton T, van Breemen RB. (2017) Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α. J Am Soc Mass Spectrom. Mar 28(3):479-485.
- Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna G. (2016) Pheromone recognition and selectivity by ComR proteins among Streptococcus species. PLoS Pathogens. (2016) Dec 1;12(12):e1005979
- Talagas A, Fontaine L, Ledesma-Garcia L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise A, Federle MJ, Prehna G, Hols P, Nessler S. (2016) Structural Insights into Streptococcal competence regulation by the cell-tocell communicaton system ComRS. PLoS Pathogens. Dec 1;12(12):e1005980.
- Cahoon LA, Freitag NE, Prehna G. (2016) A structural comparison of Listeria monocytogenes protein chaperones PrsA1 and PrsA2 reveals molecular features required for virulence. Mol Microbiol. Jul;101(1):42-61. doi: 10.1111/mmi.13367.
- Prehna G, Ramirez BE, Lovering AL. (2014) The Lifestyle Switch Protein Bd0108 of Bdellovibrio bacteriovorus Is an Intrinsically Disordered Protein. PLoS One. Dec 16;9(12):e115390. (Recommended by F1000)
- Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC. (2013) Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System. J Biol Chem. Jun 14;288(24):17782-90.
- Sobhanifar S. Prehna G, Strynadka NC. (2013) BlaR1 and MecR1 gene products of Staphylococcus aureus.The Handbook of Proteolytic Enzymes 3rd Edition. (1):1237-1242.
- Narayanan R, Zhu L, Velmurugu Y, Roca J, Kuznetsov SV, Prehna G, Lapidus LJ, Ansari A. (2012) Exploring the energy landscape of nucleic acid hairpins using laser temperature-jump and microfluidic mixing. J Am Chem Soc. Nov 21;134(46):18952-63.
- Prehna G, Lee Y, Vuckovic M, Okon M, McIntosh LP, Foster L, Finlay BB, Strynadka NC. (2012) The Zinc Regulated Antivirulence Pathway of Salmonella is a Multi-protein Immunoglobulin Adhesion System. J Biol Chem. Sep 21;287(39):32324-37.
- Prehna G, Zhang G, Gong X, Duszyk M, Okon M, McIntosh LP, Weiner JH, Strynadka NC. (2012) A Protein Export Pathway Involving Escherichia coli Porins. Structure. Jul 3;20(7) :1154-66. PMID: 22658749
- Burkinshaw B, Prehna G, Worrall L, Strynadka NC. (2012) Structure of Salmonella Effector Protein SopB N-terminal domain in complex with Host Rho GTPase Cdc42. J Biol Chem. Apr 13;287(16):13348-55.
- Hu X, Prehna G, Stebbins CE. (2007) Targeting Plague Virulence Factors: A Combined Machine Learning Method and Multiple Conformational Virtual Screening for the Discovery of Yersinia Protein Kinase A Inhibitors. J Med Chem. Aug 23;50(17):3980-3
- Prehna G, Stebbins CE. (2007) A Rac1-GDP Trimer Complex Binds Zinc with Tetrahedral and Octahedral Coordination Displacing Magnesium. Acta Crystallographica D. D63, 628-635.
- Prehna G, Ivanov M, Bliska JB, Stebbins CE. (2006) Yersinia Virulence Depends on Mimicry of Host Rho-family Nucleotide Dissociation Inhibitors. Cell. 126: 869-880. (Recommended by F1000)
- Ceccarelli C, Liang ZX, Strickler M, Prehna G, Goldstein BM, Klinman JP,Bahnson BJ. (2004) Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. Biochemistry. May 11;43(18):5266-77.
- Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM. (2002). Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. J Med Chem. Jan 31;45(3):703-12.