Publications and Patents

2024

 

  1. Khan WM, Jesus CV, Mittermuller BA, Sareen S, Lee V, Schroth RJ, Hu P and Chelikani P. 2024. Role of socioeconomic factors and interkingdom crosstalk in the dental plaque microbiome in early childhood caries. Cell Reports. (under review).

    2.  

  2. Singh N, Cunnington RH, Bhagirath AY, Vaishampayan A, Khan WM, Gupte T, Duan K, Gounni AS, Dakshinamurti A, Hanrahan JW and Chelikani P. 2024. Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis. iScience. (in-revision).

    3.  

  3. Manerkar M, Jesus CV, Mittermuller BA, Lee VHK, Singh S, Bertone M, Chelikani P and Schroth RJ. 2024. Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial. Caries Research. (under review).

    4.  

  4. Schroth RJ, Bajwa S, Lee VHK, Mittermuller BA, Singh S, Jesus CV, Bertone M, and Chelikani P. 2024. An open-label, parallel-group, randomized clinical trial of different silver diamine fluoride application intervals to arrest dental caries. BMC Oral Health. (under review).

    5.  

  5. Khan MW, Xing DFL, Schroth RJ, Chelikani P, Hu P. 2024. A cross-cohort analysis of dental plaque microbiome in early childhood caries. iScience. (under review).

    6.  

  6. Maghsoudi S, Bhatia V, Hinton M, Singh N, Khan WM, Chelikani P, Dakshinamurti S. 2024. Adenylyl Cyclase Isoform 6 in the Pulmonary Artery is Inhibited by Hypoxia and Cysteine Nitrosylation. Am J Respir Cell Mol Biol. (in-revision).

    7.  

  7. Singh N, Ulmer B, Medapati MR, Zhang C, Schroth RJ, Ghavami S and Chelikani P. 2024. Bitter taste receptor T2R14 and autophagy flux in gingival epithelial cells. Cells. 13(6): 531. [click here]

    8.  

    This work was selected as the cover art for the March 2024 (Vol 13, Issue 6) of Cells [click here]

     

  8. Singh N, Ghavami S and Chelikani P. 2024. Characterization of bitter taste receptor dependent autophagy in oral epithelial cells. Methods in Molecular Biology. In press. [click here]

 

 

2023

 

  1. Bhatia V, Maghsoudi S, Hinton M, Bhagirath AY, Singh N, Jaggupilli A, Chelikani P, and Dakshinamurti S. 2023. Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin. Biology (Basel). 12 (4): 572. [click here]

    2.  

  2. Jesus CV, Mittermuller BA, Hu P, Schroth RJ and Chelikani P. 2023. Association between downstream taste signaling genes, oral microbiome, and severe early childhood caries. Int. J. Mol. Sci. 24 (1): 81. [click here]

     

 

2022

 

  1. de Jesus VC, Mittermuller BA, Hu P, Schroth RJ and Chelikani P. 2022. Genetic variants in taste genes play a role in oral microbial composition and early childhood caries susceptibility. iScience.  25 (12): 105489. [click here]

     

  2. Bhatia V, de Jesus VC, Shaik FA, Jaggupilli A, Singh N, Chelikani P, Atukorallaya D. Extraoral expression and characterization of bitter taste receptors in Astyanax mexicanus (Mexican Tetra Fish). FASEB BioAdvances. 2022. [click here]

     

    3. This work was selected as the cover art for the September 2022 (Vol 4, Issue 9) of FASEB Bioadvances [click here]

     

  3. Bhagirath AY, Bhatia V, Medapati MR, Singh N, Hinton M, Chelikani P and Dakshinamurti S. 2022. Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gas. FASEB Bioadvances. 4 (3): 180-196. [FASEB - click here]

     

    4. This work was selected as the cover art for the March 2022 (Vol 4, Issue 3) of FASEB Bioadvances [click here]

     

  4. Medapati MR, Bhagirath A, Singh N and Chelikani P. 2022. Pharmacology of T2R mediated host-microbe interactions. Handbook of Experimental Pharmacology. 275: 177-202. [PubMed - click here]

 

2021

 

  1. de Jesus VC, Singh M, Schroth RJ, Chelikani P, Hitchon C. Association of bitter taste receptor T2R38 polymorphisms, oral microbiota and rheumatoid arthritis. Curr Issues Mol Biol. 2021.43(3):1460-1472. [MDPI - click here]

     

  2. Medapati MR, Bhagirath A, Singh N, Schroth RJ, Bhullar RP, Duan K, Chelikani P. Bitter taste receptor T2R14 modulates gram-positive bacteria internalization and survival in gingival epithelial cells. Int J Mol Sci. 2021.22(18):9920. [PubMed - click here]

     

    This work was Recommended by Faculty Opinions:Interesting hypothesis, New Finding Schröder J: Faculty Opinions Recommendation of [Medapati MR et al., Int J Mol Sci 2021 22(18)]. In Faculty Opinions, 16 Nov 2021; 10.3410/f.740878979.793589603.

     

  3. Medapati MR, Singh N, Bhagirath A, Duan K, Triggs-Raine B, Batista ER, Chelikani P. Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial cells. FASEB J. 2021. 35(3):e21375. [PubMed - click here]

     

  4. de Jesus VC, Khan MW, Mittermuller B, Duan K, Hu P,Schroth RJ, Chelikani P. Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries. Front Microbiol. 2021.12:683685. [PubMed - click here]

    5.  

  5. Singh N, Bhagirath A, Medapati MR, de Jesus VC, Chelikani P. Chemistry and biological mechanisms of peptides that modulate taste. Food Proteins and Peptides: Emerging Biofunctions, Food and Biomaterial Applications. Edited by Udenigwe CC. Royal Society of Chemistry. 2021.12:683685. [PubMed - click here]

 

2020

 

  1. de Jesus VC, Shikder R, Oryniak D, Mann K, Alamri A, Mittermuller B, Duan K, Hu P, Schroth RJ, Chelikani P. Sex-based diverse plaque microbiota in children with severe caries. J Dent Res. 2020. 99(6):703-712. [PubMed - click here]

 

  1. Singh N, Shaik FA, Myal Y, Chelikani P. Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells. Mol Cell Biochem. 2020. 465(1-2):199-214. [PubMed - click here]

 

  1. Shaik FA, Chelikani P. Differential effects of sphingomyelin and cholesterol modification on the agonist-induced bitter taste receptor T2R14 signaling. Mol Cell Biochem. 2020. 463(1-2):57-66 [PubMed - click here]

 

2019

 

  1. Zhang C, Alashi MA, Singh N, Chelikani P, Aluko ER. Glycated beef protein hydrolysates as sources of bitter taste modifiers. Nutrients. 2019. 11(9). E2166. [PubMed - click here]

 

  1. Shaik FA, Jaggupilli A, Chelikani P. Highly conserved intracellular H208 residue influences agonist selectivity in bitter taste receptor T2R14. BBA Biomembranes. 2019. 1861(12): 183057. [PubMed - click here]

 

  1. Jaggupilli A, Howard R, Aluko RE, Chelikani P. Advanced Glycation End-Products Can Activate or Block Bitter Taste Receptors. Nutrients. 2019. 11(6). E1317. [PubMed - click here]

 

  1. Xu Q, Singh N, Hong H, Yan X, Yu W, Jiang X, Chelikani P, Wu J. Hen protein-derived peptides as the blockers of human bitter taste receptors T2R4, T2R7 and T2R14. Food Chem. 2019. 283:621-627. [PubMed - click here]

 

  1. Shaik FA, Medapati MR, and Chelikani P. Cholesterol modulates signaling of the chemosensory bitter taste receptor T2R14 in human airway cells. Am J Physiol Lung Cell Mol Physiol. 2019. 316(1):L45-L57. [PubMed - click here]

 

  1. Jaggupilli A, Singh N, de Jesus VC, Soussi Gounni M, Dhanaraj P, and Chelikani P. Chemosensory bitter taste receptors (T2Rs) are activated by multiple antibiotics. FASEB J. 2019. 33(1):501-517. [PubMed - click here]

 

 

2018

 

  1. Jaggupilli A, Singh N, de Jesus VC, Duan K and Chelikani P. Characterization of the binding sites for bacterial acyl homoserine lactones (AHLs) on human bitter taste receptors (T2Rs).

    ACS Infectious Diseases. 2018. 4(7): 1146-1156. [PubMed - click here]

 

  1. Sikarwar AS, Hinton M, Santhosh KP, Dhanaraj P, Talabis M, Chelikani P, and Dakshinamurti S. Hypoxia Inhibits Adenylyl Cyclase Catalytic Activity in a Porcine Model of Persistent Pulmonary Hypertension of the Newborn. Am J Physiol Lung Cell Mol Physiol. 2018. 315(6):L933-L944. [PubMed - click here]

 

  1. Zhang C, Alashi MA, Singh N, Liu K, Chelikani P and Aluko RE. Beef protein derived peptides as bitter taste receptor T2R4 blockers. J. Agric. Food Chem. 2018. 66:4902–4912.[PubMed - click here]

 

  1. Liu K, Jaggupilli A, Dhanaraj P and Chelikani P. Plasticity of the ligand binding pocket in bitter taste receptor T2R7. BBA Biomembranes. 2018. 1860:991-999.[PubMed - click here]

 

  1. Jaggupilli A, Dhanaraj P, Pritchard A, Sorenson JL, Dakshinamurti S and Chelikani P. Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands. Mol Cell Biochem. 2018. 446 (8): 63-72. [PubMed - click here]

 

 

PATENTS

  1. Food protein-derived peptides as bitter taste receptor blockers. WO/2019/161487.

  2. Bitter taste receptor constitutively active mutants. WO/2013/159227.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

PUBLICATIONS

[2018 - 2024]

UNIVERSITY OF MANITOBA

DENTISTRY

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ORAL BIOLOGY

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Chelikani Lab