Publications and Patents

2024

 

  1. Gupte T, Singh N, Bhatia V, Arora K, Amiri S, Fernhyhough P, Naren AP, Dakshinamurti S and Chelikani P. 2024. T2R14 mediated antimicrobial responses through interactions with CFTR. bioRxiv. https://doi.org/10.1101/2024.04.25.591203

    2.  

  2. Khan WM, Jesus CV, Mittermuller BA, Sareen S, Lee V, Schroth RJ, Hu P and Chelikani P. 2024. Role of socioeconomic factors and interkingdom crosstalk in the dental plaque microbiome in early childhood caries. Cell Reports. 43(8):114635. [click here]

    3.  

  3. Singh N, Cunnington RH, Bhagirath AY, Vaishampayan A, Khan WM, Gupte T, Duan K, Gounni AS, Dakshinamurti S, Hanrahan JW and Chelikani P. 2024. Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis. iScience. (in-revision).

    4.  

  4. Abdullah MA, Jesus CV, Lee VHK, Chelikani P and Schroth RJ. 2024. Associations Between Taste Preferences and Feeding Practices and Early Childhood Caries (ECC). Journal of Dentistry for Children. (in-revision).

    5.  

  5. Manerkar M, Jesus CV, Mittermuller BA, Lee VHK, Singh S, Bertone M, Chelikani P and Schroth RJ. 2024. Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.

    6.  

  6. Srivastava M, Schroth RJ, Sareen S, Lee VHK, Jesus CV, Mittermuller BA, Singh S, Bertone M, Chelikani P. 2024. Oral Health-Related Quality of Life of Children in a Randomized Clinical Trial of Different Treatment Regimens of Silver Diamine Fluoride. Journal of Dentistry for Children. (In press).

    7.  

  7. Schroth RJ, Bajwa S, Lee VHK, Mittermuller BA, Singh S, Jesus CV, Bertone M, and Chelikani P. 2024. An open-label, parallel-group, randomized clinical trial of different silver diamine fluoride application intervals to arrest dental caries. BMC Oral Health. (In press).

    8.  

  8. Khan MW, Xing DFL, Schroth RJ, Chelikani P, Hu P. 2024. A cross-cohort analysis of dental plaque microbiome in early childhood caries. iScience. 27(8):110447. [click here]

    9.  

  9. Maghsoudi S, Bhatia V, Hinton M, Singh N, Khan WM, Chelikani P, Dakshinamurti S. 2024. Adenylyl Cyclase Isoform 6 in the Pulmonary Artery is Inhibited by Hypoxia and Cysteine Nitrosylation. Am J Respir Cell Mol Biol. [click here]

    10.  

    This work was selected for an Editorial commentary: Am J Respir Cell Mol Biol [click here]

     

  10. Singh N, Ulmer B, Medapati MR, Zhang C, Schroth RJ, Ghavami S and Chelikani P. 2024. Bitter taste receptor T2R14 and autophagy flux in gingival epithelial cells. Cells. 13(6): 531. [click here]

    11.  

    This work was selected as the cover art for the March 2024 (Vol 13, Issue 6) of Cells [click here]

     

  11. Singh N, Ghavami S and Chelikani P. 2024. Characterization of bitter taste receptor dependent autophagy in oral epithelial cells. Methods in Molecular Biology. In press. [click here]

 

 

2023

 

  1. Bhatia V, Maghsoudi S, Hinton M, Bhagirath AY, Singh N, Jaggupilli A, Chelikani P, and Dakshinamurti S. 2023. Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin. Biology (Basel). 12 (4): 572. [click here]

    2.  

  2. Jesus CV, Mittermuller BA, Hu P, Schroth RJ and Chelikani P. 2023. Association between downstream taste signaling genes, oral microbiome, and severe early childhood caries. Int. J. Mol. Sci. 24 (1): 81. [click here]

     

 

2022

 

  1. de Jesus VC, Mittermuller BA, Hu P, Schroth RJ and Chelikani P. 2022. Genetic variants in taste genes play a role in oral microbial composition and early childhood caries susceptibility. iScience.  25 (12): 105489. [click here]

     

  2. Bhatia V, de Jesus VC, Shaik FA, Jaggupilli A, Singh N, Chelikani P, Atukorallaya D. Extraoral expression and characterization of bitter taste receptors in Astyanax mexicanus (Mexican Tetra Fish). FASEB BioAdvances. 2022. [click here]

     

    3. This work was selected as the cover art for the September 2022 (Vol 4, Issue 9) of FASEB Bioadvances [click here]

     

  3. Bhagirath AY, Bhatia V, Medapati MR, Singh N, Hinton M, Chelikani P and Dakshinamurti S. 2022. Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gas. FASEB Bioadvances. 4 (3): 180-196. [FASEB - click here]

     

    4. This work was selected as the cover art for the March 2022 (Vol 4, Issue 3) of FASEB Bioadvances [click here]

     

  4. Medapati MR, Bhagirath A, Singh N and Chelikani P. 2022. Pharmacology of T2R mediated host-microbe interactions. Handbook of Experimental Pharmacology. 275: 177-202. [PubMed - click here]

 

2021

 

  1. de Jesus VC, Singh M, Schroth RJ, Chelikani P, Hitchon C. Association of bitter taste receptor T2R38 polymorphisms, oral microbiota and rheumatoid arthritis. Curr Issues Mol Biol. 2021.43(3):1460-1472. [MDPI - click here]

     

  2. Medapati MR, Bhagirath A, Singh N, Schroth RJ, Bhullar RP, Duan K, Chelikani P. Bitter taste receptor T2R14 modulates gram-positive bacteria internalization and survival in gingival epithelial cells. Int J Mol Sci. 2021.22(18):9920. [PubMed - click here]

     

    This work was Recommended by Faculty Opinions:Interesting hypothesis, New Finding Schröder J: Faculty Opinions Recommendation of [Medapati MR et al., Int J Mol Sci 2021 22(18)]. In Faculty Opinions, 16 Nov 2021; 10.3410/f.740878979.793589603.

     

  3. Medapati MR, Singh N, Bhagirath A, Duan K, Triggs-Raine B, Batista ER, Chelikani P. Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial cells. FASEB J. 2021. 35(3):e21375. [PubMed - click here]

     

  4. de Jesus VC, Khan MW, Mittermuller B, Duan K, Hu P,Schroth RJ, Chelikani P. Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries. Front Microbiol. 2021.12:683685. [PubMed - click here]

    5.  

  5. Singh N, Bhagirath A, Medapati MR, de Jesus VC, Chelikani P. Chemistry and biological mechanisms of peptides that modulate taste. Food Proteins and Peptides: Emerging Biofunctions, Food and Biomaterial Applications. Edited by Udenigwe CC. Royal Society of Chemistry. 2021.12:683685. [PubMed - click here]

 

2020

 

  1. de Jesus VC, Shikder R, Oryniak D, Mann K, Alamri A, Mittermuller B, Duan K, Hu P, Schroth RJ, Chelikani P. Sex-based diverse plaque microbiota in children with severe caries. J Dent Res. 2020. 99(6):703-712. [PubMed - click here]

 

  1. Singh N, Shaik FA, Myal Y, Chelikani P. Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells. Mol Cell Biochem. 2020. 465(1-2):199-214. [PubMed - click here]

 

  1. Shaik FA, Chelikani P. Differential effects of sphingomyelin and cholesterol modification on the agonist-induced bitter taste receptor T2R14 signaling. Mol Cell Biochem. 2020. 463(1-2):57-66 [PubMed - click here]

 

 

PATENTS

  1. Food protein-derived peptides as bitter taste receptor blockers. WO/2019/161487.

  2. Bitter taste receptor constitutively active mutants. WO/2013/159227.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

PUBLICATIONS

[2020 - 2024]

UNIVERSITY OF MANITOBA

DENTISTRY

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ORAL BIOLOGY

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Chelikani Lab