Department of Chemistry • University of Manitoba

RNA Biochemistry


We study protein-RNA interactions in interesting biological systems using a combination of biochemistry, structural biology, and molecular biology.

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Recent News…
Follow the McKenna Lab on Twitter: @mckennalab

June: The University of Manitoba will be hosting RiboWest in 2019!!! Details to follow.

June: Our work demonstrating the quadruplex substrate specificity of the helicase DDX21 was accepted in BBA-General Subjects. Congrats to Ewan McRae (Ph.D. student) who led the work, with assists from Steven Dupas (University of Manitoba URA) and Dave Davidson (NMR Facilities Manager)!

June: Congrats to Ph.D. student Ewan McRae who received the RiboClub-RiboWest travel award! Based on his presentation at RiboWest, he was invited to present the same work at RiboClub in the fall!

May: Dr. McKenna received a 2017 University of Manitoba Merit Award for his contributions to Research and Service!

May: Congrats to a former McKenna Lab member, Dr. Trushar Patel, who has received a Tier II Canada Research Chair in RNA & Protein Biophysics at the University of Lethbridge!!! Details here!

May: Our review on the innate immunity enzyme PKR written with Dr. Patel's group at the University of Lethbridge is now published in Biotechnology and Genetic Engineering Reviews!

April: Dr. McKenna was given the Department of Chemistry "Outstanding contributions to the Research Program" award!

April: Our work with the Stetefeld Group at the University of Manitoba determining the high-resolution structure of a DNA G-quadruplex was accepted in Nucleic Acids Research!

April: Congrats to the Stetefeld, McKenna, Mark, and O'Neil groups on our successful NSERC-RTI to add Quasi-elastic light scattering to our SEC-MALS instrument at the University of Manitoba.

March: Congrats to Daniel Gussakovsky (NSERC USRA), Steven Dupas (University of Manitoba URA), and Taegi Choi (Faculty of Science USRA) on their award. All three undergraduate students will be joining the group for summer 2018!

March: Our work with the Lin and Stetefeld Groups at the University of Manitoba studying neutrophil and breast cancer cell migration was accepted in Advanced Biosystems!

January: Our group (with Dr. Stetefeld's group as co-PI) has received a 5-year Canadian Institutes of Health Research Project Grant to continue our study of helicases that regulate RNA structure in the context of cancer! You can read the details about the regional press conference here.

January: Congrats to Amit Koul, who received a travel award to present his work on viral RNA pattern recognition receptors at the International Congress of Cell Biology in Hyderabad, India.

January: Our work with the Stetefeld Group at the University of Manitoba investigating protein interactions at DNA replication forks was accepted in Biophysical Journal!

November: Welcome to Taegi Choi, a new undergraduate research student in the group!

Congrats to Ewan, Evan, and Pauline for their recent review in the Journal of Nucleic Acids special issue on G-quadruplexes highlighting protein-quadruplex interactions!

Congrats to Edis et. al. for their recent publication in the PLoSOne highlighting the structural features of an adenovirus non-coding RNA!

Our group has renewed a Cancer Research Society Operating Grant to continue our study of helicases that regulate non-coding RNAs in the context of cancer!

Welcome to our two new honours thesis students, Lok Tin Hui and Jesse Slota!

Congrats to Evan et. al. for their recent publication uncovering a non-coding RNA central to cancer cell survival in Molecular Cancer!