PUBLICATIONS (Select)

Below is a selection of publications produced by members of the McManus laboratory. Each article is linked to the full abstract found at Pubmed.com.

2024

73. Campos Gudiño R, Neudorf NM, Andromidas D, Lichtensztej Z and McManus KJ. Loss of EMI1 compromises chromosome stability and is associated with cellular transformation in colonic epithelial cell contexts. Br J Cancer. 2024. DOI:10.1038/s41416-024-02855-9

72. Campos Gudiño R, Rutherford KA and McManus KJ. Evaluating chromosome instability and genotoxicity through single-cell quantitatvie imaging microscopy. Methods in Molecular Biology. 2024:2825:309-31. DOI:10.1007/978-1-0716-3946-7_18

71. The Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports. 2024;14:7526. DOI:10.1038/s41598-024-54655-z

70. Rutherford KA and McManus KJ. PROTACS: Current and future potential as a precision medicine strategy to combat cancer. Molecular Cancer Therapeutics. 2024;23:454-63. DOI:10.1158/1535-7163.MCT-23-0747

2023

69. Köbel M, Yang RZ, Kang EY, Al-Shamma Z, Cook LS, Kinloch M, Carey M, Hopkins L, Nelson GS, McManus KJ, Vizeacoumar FS, Vizeacoumar FJ, Freywald A, Fu Y, Reuss DE and Lee CH. Survey of NF inactivation by surrogate immunohistochemistry in ovarian carcinomas. Gynecologic Oncology. 2023;178:80-8. DOI:10.1016/j.ygyno.2023.09.016

68. Terceiro LEL, Ikeogu N, Lima MF, Edechi CA, Nickel BE, Fischer G, Leygue E, McManus KJ and Myal Y. Navigating the blood-brain barrier: Challenges and therapeutic strategies in breast cancer brain metastases. International Journal of Molecular Sciences. 2023:24:12034. DOI:10.3390/ijms241512034

67. Liu Q, Huang S, Desautels D, McManus KJ, Murphy L and Hu P. Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer. Computational and Structural Biotechnology Journal 2023:21;2940-9. DOI: 10.1016/j.csbj.2023.05.002

66. Campos Gudiño R, McManus KJ and Hombach-Klonisch S. Aberrant HMGA2 expression sustains genome instability that promotes metastasis and therapeutic resistance in colorectal cancer. Cancers (Basel) 2023:15;1735. DOI: 10.3390/cancers15061735

65. Casalino S, Bruce S, Serfas K, Altman AD, Kean S, Lambert P, McManus KJ, Hartley JN and Nachtigal MW. Exploring the role of a multidisciplinary hereditary gynecologic oncology clinic in epithelial ovarian cancer risk-reducing surgical decision-making practices: A mixed-methods study. J Genet Couns 2023:00;1-16. DOI: 10.1002/jgc4.1684

2022

64. Winchar K, Lambert P, McManus KJ, Chodirker B, Kean S, Serfas K, Decker K, Nachtigal MW and Altman AD. Referral, genetic counselling, and BRCA testing in the Manitoba high-grade serous ovarian cancer population, 2004-2019. Current Oncology 2022;29:9365-76. DOI: 10.3390/curroncol29120735

63.Neudorf NM, Thompson LL, Lichtensztejn L, Razi T and McManus KJ. Reduced SKP2 expression adversely impacts genome stability and promotes cellular transformation in colonic epithelial cells. Cells 2022;11:3731. DOI: 10.3390/cells11233731

62. Jeusset LM and McManus KJ. Characterizing and exploiting the many roles of aberrant H2B monoubiquitination in cancer pathogenesis. Seminars in Cancer Biology. 2022;10:859582. DOI: 10.1016/j.semcancer.2021.12.007

61. Palmer, MCL, Neudorf, NM, Farrell, AC, Razi T, Lichtensztejn, Z and McManus, KJ. The F-box protein, FBXO7 is required to maintain chromosome stability in humans. Human Molecular Genetics. 2022;31:1471-86. DOI: 10.1093/hmg/ddab330

60. Thompson LL, Rutherford KA, Lepage CC and McManus KJ. Aberrant SKP1 expression: Diverse mechanisms impacting genome and chromosome stability. Frontiers in Cell and Developmental Biology. 2022;10:859582. DOI: 10.3389/fcell.2022.859582

2021

59. Hugh JC, Haddon LSJ, Githaka JM, Bigras G, Hu X, Madden B, Hanson J, Gabos Z, Giannakopoulos NV, Huang F, Hitt MM, McManus KJ, Olson D, Dabbs K and Mackey JR. DREAM, a Possible Answer to the Estrogen Paradox of the Women’s Health Initiative Trial. Heliyon Journal. 2021;8:e08666. DOI: 10.1016/j.heliyon.2021.e08666

57. *Campos Gudiño R, *Farrell AC, *Neudorf NM and McManus KJ. A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members. International Journal of Molecular Sciences. 2022;23:84. DOI: 10.3390/ijms23010084 *denotes co-first authorship

56. Jeusset, LM and McManus, KJ. Exploring Candidate Human Synthetic Lethal Interactions through siRNA and Quantitative Imaging-based Approaches. Methods in Molecular Biology. 2021:2381:151-73. DOI: 10.1007/978-1-0716-1740-3_8

55. Jeusset, LM and McManus, KJ. Employing Cross-species Approaches to Construct Humanized Genetic Interaction Maps. Methods in Molecular Biology. 2021:2381:115-33. DOI: 10.1007/978-1-0716-1740-3_6

54. Thompson, LL, Rutherford, KA, Lepage, CC and McManus, KJ. The SCF Complex is Essential to Maintain Genome and Chromosome Stability. International Journal of Molecular Sciences. 2021;22:8544. DOI: 10.3390/ijms22168544

53. Morden, CR, Farrell, AC, Sliwowski, M, Lichtensztejn, Z, Altman, AD, Nachtigal, MW and McManus, KJ. Chromosome Instability is Prevalent and Dynamic in High-Grade Serous Ovarain Cancer Patient Samples. Gynecologic Oncology. 2021;161:769-778. DOI: 10.1016/j.ygyno.2021.02.038

52. Jeusset, LM, Guppy, BJ, Lichtensztejn, Z, McDonald, D and McManus, KJ. Reduced USP22 Expression Impairs Mitotic Removal of H2B monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability that May Promote Oncogenesis. Cancers (Basel). 2021;13:1043. DOI: 10.3390/cancers13051043

51. Heinze, K, Holzer, M, Ungelenk, M, Gerth, M, Thomale, J, Heller, R, Morden, CR, McManus, KJ, Mosig, AS, Durst, M, Runnebaum, IB and Hafner, N. RUNX3 Transcript Variants have Dichotomous Roles in Ovarian Carcinoma and Influence Platin Sensitivity and Angiogenesis. Cancers (Basel). 2021;13:476. DOI: 10.3390/cancers13030476

50. Lepage, CC, Palmer, MCL, Farrell, AC, Neudorf, NM, Lichtensztejn, Z, Nachtigal, MW and McManus, KJ. Reduced SKP1 and CUL1 Expression Underlie Increases in Cyclin E1 and Chromosome Instability in Cellular Precursors of High-grade Serous Ovarian Cancer. British Journal of Cancer. 2021;124:1699-1710. DOI: 10.1038/s41416-021-01317-w

49. Bungsy, M, Palmer, MCL, Jeusset, LM, Neudorf, NM, Lichtensztejn, Z, Nachtigal, MW and McManus, KJ. Reduced RBX1 Expression Induces Chromosome Instability and Promotes Cellular Transformation in High-Grade Serous Ovarian Cancer Precursor Cells. Cancer Letters. 2021;500:194-207. DOI: 10.1016/j.canlet.2020.11.051

2020

48. Vishwakarma, R and McManus, KJ. Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes. Cancers (Basel). 2020;12:824. DOI: 10.3390/cancers12040824

47. Thompson, LL, Baergen, AK, Lichtensztejn, Z and McManus, KJ. Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover. Cancers (Basel). 2020;12:531. DOI: 10.3390/cancers12030531

46. Lepage, CC, Thompson, LL, Larson, BB and McManus, KJ. An Automated, Single Cell Quantitative Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability. Cells. 2020;9:E344. DOI: 10.3390/cells9020344

45. Leylek, TR, Jeusset, LM, Lichtensztejn, Z and McManus, KJ. Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes. Scientific Reports. 2020;10:592. DOI: 10.1038/s41598-020-57530-9

2019

44. Baergen, AK, Jeusset, LM, Lichtensztejn, Z and McManus, KJ. Diminished Condensin Gene Expression Drives Chromosome Instability that May Contribute to Colorectal Cancer Pathogenesis. Cancers (Basel). 2019;11:1066. PMID: 31357676

43. Jeusset, LM and McManus, KJ. Developing Targeted Therapies that Exploit Aberrant Histone Ubiquitination in Cancer. Cells. 2019;16:E165. PMID: 30781493

42. *Lepage, CC, *Morden, CR, Palmer, MCL, Nachtigal, MW and McManus KJ. Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity. Cancers (Basel). 2019;11:E226. PMID: 30781398 *These authors contributed equally and are listed alphabetically.

2018

41. Cisyk, AL, Nugent Z, Wightman, RH, Singh H and McManus, KJ. Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers. Neoplasia. 2018;20:943-50. PMID: 30121009

2017

40. Jeusset, LMP and McManus, KJ. Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer. Cancers (Basel). 2017;9:E167. PMID: 29210986

39. Thompson, LL., Jeusset, LMP, Lepage, CC and McManus, KJ. Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer. Cancers (Basel). 2017;9:151. PMID: 29104272

38. Asbaghi, Y, Thompson, LL, Lichtensztejn, Z, and McManus, KJ. KIF11 Silencing and Inhibition Induces Chromosome Instability that may Contribute to Cancer. Genes, Chromosomes and Cancer. 2017;56:668-80. PMID: 28510357

37. Guppy, BJ., and McManus, KJ. Synthetic Lethal Targeting of RNF20 through PARP1 Silencing and Inhibition. Cellular Oncology. 2017;40:281-92. PMID: 28462496

36. Penner-Goeke, S, Lichtensztejn, Z, Neufeld, M, Ali, JL, Altman, AD, Nachtigal, MW, and McManus, KJ. The Temporal Dynamics of Chromosome Instability in Ovarian Cancer Cell Lines and Primary Patient Samples. PLoS Genetics. 2017;13:e1006707. PMID: 28376088

35. McAndrew, EN, and McManus, KJ. The Enigmatic Oncogene and Tumor Suppressor-like Properties of RAD54B: Insights into Genome Instability and Cancer. Genes, Chromosomes and Cancer. 2017;56:513-23. PMID: 28295846

34. Guppy, BJ, Jeusset, LM-P, and McManus, KJ. The Relationship between DOT1L, Histone H3 Methylation and Genome Stability in Cancer. Current Molecular Biology Reports. 2017;3:18-27. Link.