LABORATORY Cancer Research in Genome Stability
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Below is a selection of publications produced by members of the McManus laboratory. Each article is linked to the full abstract found at



57. Palmer, MCL, Neudorf, NM, Farrell, AC, Razi T, Lichtensztejn, Z and McManus, KJ. The F-box protein, FBXO7 is required to maintain chromosome stability in humans. Human Molecular Genetics. 2021 (In Press). DOI: 10.1093/hmg/ddab330

56. Jeusset, LM and McManus, KJ. Exploring Candidate Human Synthetic Lethal Interactions through siRNA and Quantitative Imaging-based Approaches. Methods in Molecular Biology. 2021:2381:151-73. DOI: 10.1007/978-1-0716-1740-3_8

55. Jeusset, LM and McManus, KJ. Employing Cross-species Approaches to Construct Humanized Genetic Interaction Maps. Methods in Molecular Biology. 2021:2381:115-33. DOI: 10.1007/978-1-0716-1740-3_6

54. Thompson, LL, Rutherford, KA, Lepage, CC and McManus, KJ. The SCF Complex is Essential to Maintain Genome and Chromosome Stability. International Journal of Molecular Sciences. 2021;22:8544. DOI: 10.3390/ijms22168544

53. Morden, CR, Farrell, AC, Sliwowski, M, Lichtensztejn, Z, Altman, AD, Nachtigal, MW and McManus, KJ. Chromosome Instability is Prevalent and Dynamic in High-Grade Serous Ovarain Cancer Patient Samples. Gynecologic Oncology. 2021;161:769-778. DOI: 10.1016/j.ygyno.2021.02.038

52. Jeusset, LM, Guppy, BJ, Lichtensztejn, Z, McDonald, D and McManus, KJ. Reduced USP22 Expression Impairs Mitotic Removal of H2B monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability that May Promote Oncogenesis. Cancers (Basel). 2021;13:1043. DOI: 10.3390/cancers13051043

51. Heinze, K, Holzer, M, Ungelenk, M, Gerth, M, Thomale, J, Heller, R, Morden, CR, McManus, KJ, Mosig, AS, Durst, M, Runnebaum, IB and Hafner, N. RUNX3 Transcript Variants have Dichotomous Roles in Ovarian Carcinoma and Influence Platin Sensitivity and Angiogenesis. Cancers (Basel). 2021;13:476. DOI: 10.3390/cancers13030476

50. Lepage, CC, Palmer, MCL, Farrell, AC, Neudorf, NM, Lichtensztejn, Z, Nachtigal, MW and McManus, KJ. Reduced SKP1 and CUL1 Expression Underlie Increases in Cyclin E1 and Chromosome Instability in Cellular Precursors of High-grade Serous Ovarian Cancer. British Journal of Cancer. 2021;124:1699-1710. DOI: 10.1038/s41416-021-01317-w

49. Bungsy, M, Palmer, MCL, Jeusset, LM, Neudorf, NM, Lichtensztejn, Z, Nachtigal, MW and McManus, KJ. Reduced RBX1 Expression Induces Chromosome Instability and Promotes Cellular Transformation in High-Grade Serous Ovarian Cancer Precursor Cells. Cancer Letters. 2021;500:194-207. DOI: 10.1016/j.canlet.2020.11.051


48. Vishwakarma, R and McManus, KJ. Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes. Cancers (Basel). 2020;12:824. DOI: 10.3390/cancers12040824

47. Thompson, LL, Baergen, AK, Lichtensztejn, Z and McManus, KJ. Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover. Cancers (Basel). 2020;12:531. DOI: 10.3390/cancers12030531

46. Lepage, CC, Thompson, LL, Larson, BB and McManus, KJ. An Automated, Single Cell Quantitative Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability. Cells. 2020;9:E344. DOI: 10.3390/cells9020344

45. Leylek, TR, Jeusset, LM, Lichtensztejn, Z and McManus, KJ. Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes. Scientific Reports. 2020;10:592. DOI: 10.1038/s41598-020-57530-9


44. Baergen, AK, Jeusset, LM, Lichtensztejn, Z and McManus, KJ. Diminished Condensin Gene Expression Drives Chromosome Instability that May Contribute to Colorectal Cancer Pathogenesis. Cancers (Basel). 2019;11:1066. PMID: 31357676

43. Jeusset, LM and McManus, KJ. Developing Targeted Therapies that Exploit Aberrant Histone Ubiquitination in Cancer. Cells. 2019;16:E165. PMID: 30781493

42. *Lepage, CC, *Morden, CR, Palmer, MCL, Nachtigal, MW and McManus KJ. Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity. Cancers (Basel). 2019;11:E226. PMID: 30781398 *These authors contributed equally and are listed alphabetically.


41. Cisyk, AL, Nugent Z, Wightman, RH, Singh H and McManus, KJ. Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers. Neoplasia. 2018;20:943-50. PMID: 30121009


40. Jeusset, LMP and McManus, KJ. Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer. Cancers (Basel). 2017;9:E167. PMID: 29210986

39. Thompson, LL., Jeusset, LMP, Lepage, CC and McManus, KJ. Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer. Cancers (Basel). 2017;9:151. PMID: 29104272

38. Asbaghi, Y, Thompson, LL, Lichtensztejn, Z, and McManus, KJ. KIF11 Silencing and Inhibition Induces Chromosome Instability that may Contribute to Cancer. Genes, Chromosomes and Cancer. 2017;56:668-80. PMID: 28510357

37. Guppy, BJ., and McManus, KJ. Synthetic Lethal Targeting of RNF20 through PARP1 Silencing and Inhibition. Cellular Oncology. 2017;40:281-92. PMID: 28462496

36. Penner-Goeke, S, Lichtensztejn, Z, Neufeld, M, Ali, JL, Altman, AD, Nachtigal, MW, and McManus, KJ. The Temporal Dynamics of Chromosome Instability in Ovarian Cancer Cell Lines and Primary Patient Samples. PLoS Genetics. 2017;13:e1006707. PMID: 28376088

35. McAndrew, EN, and McManus, KJ. The Enigmatic Oncogene and Tumor Suppressor-like Properties of RAD54B: Insights into Genome Instability and Cancer. Genes, Chromosomes and Cancer. 2017;56:513-23. PMID: 28295846

34. Guppy, BJ, Jeusset, LM-P, and McManus, KJ. The Relationship between DOT1L, Histone H3 Methylation and Genome Stability in Cancer. Current Molecular Biology Reports. 2017;3:18-27. Link.


33. McAndrew, EN, Lepage, CC, and McManus, KJ. The Synthetic Lethal Killing of RAD54B-deficient Colorectal Cancer Cells by PARP1 Inhibition is Enhanced with SOD1 Inhibition. Oncotarget. 2016;7:87417-30. PMID: 27902462


32. Yan, Y, Cooper, C, Hamedani, MK, Guppy, B, Wayne, X, Tsuyuki, D, Zhang, C, Nugent, Z, Blanchard, A, Davie, JR, McManus, K, Murphy, LC, Myal, Y, and Leygue, E. The Steroid Receptor RNA Activator Protein (SRAP) Controls Cancer Cell Migration/Motility. FEBS Letters. 2015;589:4010-8. PMID: 26581859

31. Sajesh, BV and McManus, KJ. Targeting SOD1 Induces Synthetic Lethal Killing in BLM- and CHEK2-deficient Colorectal Cancer Cells. Oncotarget. 2015;6:27907-22. PMID: 26318585

30. Thompson, LL, and McManus, KJ. A Novel Multiplexed Approach to Detect Phenotypes that Underlie Chromosome Instability in Human Cells. PLoS ONE. 2015;10:e0123200. PMID: 25893404

29. Cisyk, AL, Penner-Goeke, S, Lichtensztejn, Z, Nugent, Z, Wightman, RH, Singh, H, and McManus, KJ. Characterizing the Prevalence of Chromosome Instability in Interval Colorectal Cancer. Neoplasia. 2015;17:306-16. PMID:25810015

28. Guppy, BJ, and McManus, KJ. Mitotic Accumulation of Di-methylated Lysine 79 of Histone H3 is Important for Maintaining Genome Integrity During Mitotis in Human Cells. Genetics. 2015;199:423-33. PMID: 25533199

27. Sajesh, BV, Cisyk, AL, and McManus, KJ. Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability in Cancer Metastasis and Genome Instability, pp 179-204. Springer International Publishing AG, Cham, Switzerland. (Book Chapter).


26. Cisyk, A, Singh, H, and McManus, KJ. Establishing a Biological Profile for Interval Colorectal Cancers. Digestive Diseases and Sciences. 2014;59:2390-402. PMID: 24839919


25. Sajesh, BV, Bailey, M, Lichtensztejn, Z, Hieter, P and McManus, KJ. Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-deficient Colorectal Cancer Cells. Genetics. 2013;195:757-67. PMID: 24002644

24. Sajesh, BV, Lichtensztejn, Z and McManus, KJ. Sister Chromatin Cohesion Defects are Associated with Chromosome Instability in Hodgkin Lymphoma Cells. BMC Cancer. 2013;13:391. PMID: 23962039

23. Sajesh, BV, Guppy, BJ and McManus, KJ. Synthetic Genetic Targeting of Genome Instability in Cancer. Cancers (Basel). 2013;5:739-61. PMID: 24202319

22. Thompson, LL, Guppy, BJ, Sawchuk, L, Davie, JR and McManus, KJ. Regulation of chromatin structure via histone post-translational modificaiton and the link to carcinogenesis. Cancer and Metastasis Reviews. 2013. PMID: 23609752

21. Price, JC, Pollock, LM, Rudd, ML. Fogoros, SK, Mohamed, H, Hanigan, CL, Le Gallo, M, NIH Intramural Sequencing Center Comparative Sequencing Program, Zhang, S, Cruz, P, Cherukuri, PF, Hansen, NF, McManus, KJ, Godwin, AK, Sgroi, DC, Mullikin, JC, Merino, MJ, Bell, DW. Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A. PLoS ONE. 2013;8:e63313. PMID: 23755103

20. van Pel, DM, Barrett, IJ, Shimizu, Y, Sajesh, BV, Guppy, BJ, Pfeifer, T, McManus, KJ and Hieter, P. An evolutionarily conserved synthetic lethal interaction network identified FEN1 as a broad-spectrum target for anticancer therapeutic development. PLoS Genetics. 2013;9:e1003254. PMID: 23382697

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